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Timothy P. Sheahan, Ph.D. - Publications

Affiliations: 
2008 Microbiology & Immunology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Microbiology Biology, Immunology
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

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Year Citation  Score
2021 Adams LE, Dinnon KH, Hou YJ, Sheahan TP, Heise MT, Baric RS. Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication. Mbio. 12. PMID 33727353 DOI: 10.1128/mBio.03149-20  0.76
2021 Martinez DR, Schaefer A, Leist SR, Gully K, Feng JY, Bunyan E, Porter DP, Cihlar T, Montgomery SA, Baric RS, Nussenzweig MC, Sheahan TP. Early therapy with remdesivir and antibody combinations improves COVID-19 disease in mice. Biorxiv : the Preprint Server For Biology. PMID 33532765 DOI: 10.1101/2021.01.27.428478  0.76
2021 Dinnon KH, Leist SR, Schäfer A, Edwards CE, Martinez DR, Montgomery SA, West A, Yount BL, Hou YJ, Adams LE, Gully KL, Brown AJ, Huang E, Bryant MD, Choong IC, ... ... Sheahan TP, et al. Publisher Correction: A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures. Nature. PMID 33469219 DOI: 10.1038/s41586-020-03107-5  0.76
2021 Schäfer A, Muecksch F, Lorenzi JCC, Leist SR, Cipolla M, Bournazos S, Schmidt F, Maison RM, Gazumyan A, Martinez DR, Baric RS, Robbiani DF, Hatziioannou T, Ravetch JV, Bieniasz PD, ... ... Sheahan TP, et al. Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo. The Journal of Experimental Medicine. 218. PMID 33211088 DOI: 10.1084/jem.20201993  0.76
2020 Iserman C, Roden CA, Boerneke MA, Sealfon RSG, McLaughlin GA, Jungreis I, Fritch EJ, Hou YJ, Ekena J, Weidmann CA, Theesfeld CL, Kellis M, Troyanskaya OG, Baric RS, Sheahan TP, et al. Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid. Molecular Cell. PMID 33290746 DOI: 10.1016/j.molcel.2020.11.041  0.76
2020 Walls AC, Fiala B, Schäfer A, Wrenn S, Pham MN, Murphy M, Tse LV, Shehata L, O'Connor MA, Chen C, Navarro MJ, Miranda MC, Pettie D, Ravichandran R, Kraft JC, ... ... Sheahan TP, et al. Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2. Cell. PMID 33160446 DOI: 10.1016/j.cell.2020.10.043  0.76
2020 Leist SR, Dinnon KH, Schäfer A, Tse LV, Okuda K, Hou YJ, West A, Edwards CE, Sanders W, Fritch EJ, Gully KL, Scobey T, Brown AJ, Sheahan TP, Moorman NJ, et al. A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice. Cell. PMID 33031744 DOI: 10.1016/j.cell.2020.09.050  0.76
2020 Schäfer A, Muecksch F, Lorenzi JCC, Leist SR, Cipolla M, Bournazos S, Schmidt F, Gazumyan A, Baric RS, Robbiani DF, Hatziioannou T, Ravetch JV, Bieniasz PD, Nussenzweig MC, Sheahan TP. Antibody potency, effector function and combinations in protection from SARS-CoV-2 infection . Biorxiv : the Preprint Server For Biology. PMID 32995782 DOI: 10.1101/2020.09.15.298067  0.76
2020 Dinnon KH, Leist SR, Schäfer A, Edwards CE, Martinez DR, Montgomery SA, West A, Yount BL, Hou YJ, Adams LE, Gully KL, Brown AJ, Huang E, Bryant MD, Choong IC, ... ... Sheahan TP, et al. A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures. Nature. PMID 32854108 DOI: 10.1038/s41586-020-2708-8  0.76
2020 Walls AC, Fiala B, Schäfer A, Wrenn S, Pham MN, Murphy M, Tse LV, Shehata L, O'Connor MA, Chen C, Navarro MJ, Miranda MC, Pettie D, Ravichandran R, Kraft JC, ... ... Sheahan TP, et al. Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2. Biorxiv : the Preprint Server For Biology. PMID 32817941 DOI: 10.1101/2020.08.11.247395  0.76
2020 Zhang K, Zheludev IN, Hagey RJ, Wu MT, Haslecker R, Hou YJ, Kretsch R, Pintilie GD, Rangan R, Kladwang W, Li S, Pham EA, Bernardin-Souibgui C, Baric RS, Sheahan TP, et al. Cryo-electron Microscopy and Exploratory Antisense Targeting of the 28-kDa Frameshift Stimulation Element from the SARS-CoV-2 RNA Genome. Biorxiv : the Preprint Server For Biology. PMID 32743589 DOI: 10.1101/2020.07.18.209270  0.76
2020 Pruijssers AJ, George AS, Schäfer A, Leist SR, Gralinksi LE, Dinnon KH, Yount BL, Agostini ML, Stevens LJ, Chappell JD, Lu X, Hughes TM, Gully K, Martinez DR, Brown AJ, ... ... Sheahan TP, et al. Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice. Cell Reports. 107940. PMID 32668216 DOI: 10.1016/j.celrep.2020.107940  0.76
2020 Iserman C, Roden C, Boerneke M, Sealfon R, McLaughlin G, Jungreis I, Park C, Boppana A, Fritch E, Hou YJ, Theesfeld C, Troyanskaya OG, Baric RS, Sheahan TP, Weeks K, et al. Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate. Biorxiv : the Preprint Server For Biology. PMID 32587965 DOI: 10.1101/2020.06.11.147199  0.76
2020 Sheahan TP, Frieman MB. The continued epidemic threat of SARS-CoV-2 and implications for the future of global public health. Current Opinion in Virology. 40: 37-40. PMID 32569751 DOI: 10.1016/j.coviro.2020.05.010  0.72
2020 Pruijssers AJ, George AS, Schäfer A, Leist SR, Gralinksi LE, Dinnon KH, Yount BL, Agostini ML, Stevens LJ, Chappell JD, Lu X, Hughes TM, Gully K, Martinez DR, Brown AJ, ... ... Sheahan TP, et al. Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice. Biorxiv : the Preprint Server For Biology. PMID 32511392 DOI: 10.1101/2020.04.27.064279  0.76
2020 Lindesmith LC, Brewer-Jensen PD, Mallory ML, Jensen K, Yount BL, Costantini V, Collins MH, Edwards CE, Sheahan TP, Vinjé J, Baric RS. Virus-host interactions between non-secretors and human norovirus. Cellular and Molecular Gastroenterology and Hepatology. PMID 32289501 DOI: 10.1016/j.jcmgh.2020.03.006  0.76
2020 Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schäfer A, Dinnon KH, Stevens LJ, Chappell JD, Lu X, Hughes TM, George AS, Hill CS, et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Science Translational Medicine. PMID 32253226 DOI: 10.1126/scitranslmed.abb5883  0.76
2020 Sheahan TP, Sims AC, Leist SR, Schäfer A, Won J, Brown AJ, Montgomery SA, Hogg A, Babusis D, Clarke MO, Spahn JE, Bauer L, Sellers S, Porter D, Feng JY, et al. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nature Communications. 11: 222. PMID 31924756 DOI: 10.1038/s41467-019-13940-6  0.76
2019 Agostini ML, Pruijssers AJ, Chappell JD, Gribble J, Lu X, Andres EL, Bluemling GR, Lockwood MA, Sheahan TP, Sims AC, Natchus MG, Saindane M, Kolykhalov AA, Painter GR, Baric RS, et al. Small molecule antiviral β-D--hydroxycytidine inhibits a proofreading-intact coronavirus with a high genetic barrier to resistance. Journal of Virology. PMID 31578288 DOI: 10.1128/JVI.01348-19  0.76
2019 Leist SR, Jensen KL, Baric RS, Sheahan TP. Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis. Plos One. 14: e0220126. PMID 31339932 DOI: 10.1371/journal.pone.0220126  0.76
2019 Brown AJ, Won JJ, Graham RL, Dinnon KH, Sims AC, Feng JY, Cihlar T, Denison MR, Baric RS, Sheahan TP. Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase. Antiviral Research. 104541. PMID 31233808 DOI: 10.1016/j.antiviral.2019.104541  0.76
2018 Sheahan TP, Baric RS. Is regulation preventing the development of therapeutics that may prevent future coronavirus pandemics? Future Virology. 13: 143-146. PMID 30546388 DOI: 10.2217/fvl-2017-0143  0.76
2018 Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Leist SR, Whitmore A, Heise MT, Baric RS. Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis. Mbio. 9. PMID 30301856 DOI: 10.1128/mBio.01753-18  0.76
2018 Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. Mbio. 9. PMID 29511076 DOI: 10.1128/mBio.00221-18  0.76
2018 Lindesmith LC, Mallory ML, Debbink K, Donaldson EF, Brewer-Jensen PD, Swann EW, Sheahan TP, Graham RL, Beltramello M, Corti D, Lanzavecchia A, Baric RS. Conformational Occlusion of Blockade Antibody Epitopes, a Novel Mechanism of GII.4 Human Norovirus Immune Evasion. Msphere. 3. PMID 29435493 DOI: 10.1128/mSphere.00518-17  0.76
2017 Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, et al. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Science Translational Medicine. 9. PMID 28659436 DOI: 10.1126/scitranslmed.aal3653  0.76
2016 Ramanan V, Trehan K, Ong ML, Luna JM, Hoffmann HH, Espiritu C, Sheahan TP, Chandrasekar H, Schwartz RE, Christine KS, Rice CM, van Oudenaarden A, Bhatia SN. Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies. Virology. 494: 236-247. PMID 27128351 DOI: 10.1016/j.virol.2016.04.020  0.76
2016 Menachery VD, Yount BL, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR, Swanstrom J, Sheahan TP, Pickles RJ, Corti D, Randell SH, et al. SARS-like WIV1-CoV poised for human emergence. Proceedings of the National Academy of Sciences of the United States of America. PMID 26976607 DOI: 10.1073/pnas.1517719113  0.76
2015 Tran V, Poole DS, Jeffery JJ, Sheahan TP, Creech D, Yevtodiyenko A, Peat AJ, Francis KP, You S, Mehle A. Multi-Modal Imaging with a Toolbox of Influenza AReporter Viruses. Viruses. 7: 5319-27. PMID 26473913 DOI: 10.3390/v7102873  0.76
2013 Sheahan TP, Rice CM. Single cell analysis of HCV-infected patient hepatocytes: the science is no longer science fiction. Gastroenterology. 145: 1199-202. PMID 24176873 DOI: 10.1053/j.gastro.2013.10.035  0.76
2012 Schwartz RE, Trehan K, Andrus L, Sheahan TP, Ploss A, Duncan SA, Rice CM, Bhatia SN. Modeling hepatitis C virus infection using human induced pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 2544-8. PMID 22308485 DOI: 10.1073/pnas.1121400109  0.76
2011 Andrus L, Marukian S, Jones CT, Catanese MT, Sheahan TP, Schoggins JW, Barry WT, Dustin LB, Trehan K, Ploss A, Bhatia SN, Rice CM. Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells. Hepatology (Baltimore, Md.). 54: 1901-12. PMID 22144107 DOI: 10.1002/hep.24557  0.76
2011 Marukian S, Andrus L, Sheahan TP, Jones CT, Charles ED, Ploss A, Rice CM, Dustin LB. Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures. Hepatology (Baltimore, Md.). 54: 1913-23. PMID 21800339 DOI: 10.1002/hep.24580  0.76
2010 Sheahan TP, Baric RS. SARS coronavirus pathogenesis and therapeutic treatment design Molecular Biology of the Sars-Coronavirus. 195-230. DOI: 10.1007/978-3-642-03683-5_13  0.76
2008 Becker MM, Graham RL, Donaldson EF, Rockx B, Sims AC, Sheahan T, Pickles RJ, Corti D, Johnston RE, Baric RS, Denison MR. Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 19944-9. PMID 19036930 DOI: 10.1073/pnas.0808116105  0.76
2004 Sundback CA, Shyu JY, Wu AJ, Sheahan TP, Wang Y, Faquin WC, Langer RS, Vacanti JP, Hadlock TA. In vitro and in vivo biocompatibility analysis of poly (glycerol sebacate) as a potential nerve guide material Materials Research Society Symposium Proceedings. 37-39.  0.76
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