Year |
Citation |
Score |
2013 |
Chen XT, Pitis P, Liu G, Yuan C, Gotchev D, Cowan CL, Rominger DH, Koblish M, Dewire SM, Crombie AL, Violin JD, Yamashita DS. Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain. Journal of Medicinal Chemistry. 56: 8019-31. PMID 24063433 DOI: 10.1021/Jm4010829 |
0.709 |
|
2013 |
DeWire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, Chen XT, Pitis PM, Gotchev D, Yuan C, Koblish M, Lark MW, Violin JD. A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. The Journal of Pharmacology and Experimental Therapeutics. 344: 708-17. PMID 23300227 DOI: 10.1124/jpet.112.201616 |
0.69 |
|
2013 |
Violin J, DeWire S, Koblish M, Chen D, Crombie A, Yamashita D, Soergel D, Lark M. An orally available mu-opioid receptor biased ligand is analgesic with reduced constipation in rodents The Journal of Pain. 14: S70. DOI: 10.1016/j.jpain.2013.01.619 |
0.647 |
|
2011 |
DeWire SM, Violin JD. Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology. Circulation Research. 109: 205-16. PMID 21737816 DOI: 10.1161/CIRCRESAHA.110.231308 |
0.703 |
|
2011 |
Rajagopal S, Ahn S, Rominger DH, Gowen-MacDonald W, Lam CM, Dewire SM, Violin JD, Lefkowitz RJ. Quantifying ligand bias at seven-transmembrane receptors. Molecular Pharmacology. 80: 367-77. PMID 21610196 DOI: 10.1124/Mol.111.072801 |
0.763 |
|
2010 |
Violin JD, DeWire SM, Yamashita D, Rominger DH, Nguyen L, Schiller K, Whalen EJ, Gowen M, Lark MW. Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance. The Journal of Pharmacology and Experimental Therapeutics. 335: 572-9. PMID 20801892 DOI: 10.1124/Jpet.110.173005 |
0.771 |
|
2010 |
Violin JD, Soergel DG, DeWire SM, Yamashita D, Rominger D, Whalen EJ, Gowen M, Lark MW. TRV120027, a β-Arrestin Biased Ligand at the Angiotensin II Type 1 Receptor, Produces Unique Pharmacology and Is a Novel Potential Therapy for Heart Failure Journal of Cardiac Failure. 16: S72. DOI: 10.1016/j.cardfail.2010.06.247 |
0.651 |
|
2009 |
Walters RW, Shukla AK, Kovacs JJ, Violin JD, DeWire SM, Lam CM, Chen JR, Muehlbauer MJ, Whalen EJ, Lefkowitz RJ. beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. The Journal of Clinical Investigation. 119: 1312-21. PMID 19349687 DOI: 10.1172/Jci36806 |
0.721 |
|
2008 |
Kim J, Zhang L, Peppel K, Wu JH, Zidar DA, Brian L, DeWire SM, Exum ST, Lefkowitz RJ, Freedman NJ. Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. Circulation Research. 103: 70-9. PMID 18519945 DOI: 10.1161/Circresaha.108.172338 |
0.783 |
|
2008 |
DeWire SM, Kim J, Whalen EJ, Ahn S, Chen M, Lefkowitz RJ. Beta-arrestin-mediated signaling regulates protein synthesis. The Journal of Biological Chemistry. 283: 10611-20. PMID 18276584 DOI: 10.1074/Jbc.M710515200 |
0.804 |
|
2007 |
Wisler JW, DeWire SM, Whalen EJ, Violin JD, Drake MT, Ahn S, Shenoy SK, Lefkowitz RJ. A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 16657-62. PMID 17925438 DOI: 10.1073/Pnas.0707936104 |
0.764 |
|
2007 |
DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK. Beta-arrestins and cell signaling. Annual Review of Physiology. 69: 483-510. PMID 17305471 DOI: 10.1146/Annurev.Physiol.69.022405.154749 |
0.785 |
|
2006 |
Violin JD, Dewire SM, Barnes WG, Lefkowitz RJ. G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics. The Journal of Biological Chemistry. 281: 36411-9. PMID 17008309 DOI: 10.1074/Jbc.M607956200 |
0.789 |
|
2005 |
Dittmer DP, Gonzalez CM, Vahrson W, DeWire SM, Hines-Boykin R, Damania B. Whole-genome transcription profiling of rhesus monkey rhadinovirus. Journal of Virology. 79: 8637-50. PMID 15956606 DOI: 10.1128/JVI.79.13.8637-8650.2005 |
0.469 |
|
2005 |
DeWire SM, Damania B. The latency-associated nuclear antigen of rhesus monkey rhadinovirus inhibits viral replication through repression of Orf50/Rta transcriptional activation. Journal of Virology. 79: 3127-38. PMID 15709032 DOI: 10.1128/JVI.79.5.3127-3138.2005 |
0.495 |
|
2004 |
Damania B, Jeong JH, Bowser BS, DeWire SM, Staudt MR, Dittmer DP. Comparison of the Rta/Orf50 transactivator proteins of gamma-2-herpesviruses. Journal of Virology. 78: 5491-9. PMID 15113928 DOI: 10.1128/Jvi.78.10.5491-5499.2004 |
0.735 |
|
2004 |
Wang L, Wakisaka N, Tomlinson CC, DeWire SM, Krall S, Pagano JS, Damania B. The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) K1 protein induces expression of angiogenic and invasion factors. Cancer Research. 64: 2774-81. PMID 15087393 DOI: 10.1158/0008-5472.Can-03-3653 |
0.729 |
|
2003 |
DeWire SM, Money ES, Krall SP, Damania B. Rhesus monkey rhadinovirus (RRV): construction of a RRV-GFP recombinant virus and development of assays to assess viral replication. Virology. 312: 122-34. PMID 12890626 DOI: 10.1016/S0042-6822(03)00195-8 |
0.465 |
|
2002 |
Bowser BS, DeWire SM, Damania B. Transcriptional regulation of the K1 gene product of Kaposi's sarcoma-associated herpesvirus. Journal of Virology. 76: 12574-83. PMID 12438583 DOI: 10.1128/Jvi.76.24.12574-12583.2002 |
0.73 |
|
2002 |
DeWire SM, McVoy MA, Damania B. Kinetics of expression of rhesus monkey rhadinovirus (RRV) and identification and characterization of a polycistronic transcript encoding the RRV Orf50/Rta, RRV R8, and R8.1 genes. Journal of Virology. 76: 9819-31. PMID 12208960 DOI: 10.1128/Jvi.76.19.9819-9831.2002 |
0.496 |
|
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