Scott M. DeWire, Ph.D. - Publications

Affiliations: 
2004 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Molecular Biology, Microbiology Biology

18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2013 Chen XT, Pitis P, Liu G, Yuan C, Gotchev D, Cowan CL, Rominger DH, Koblish M, Dewire SM, Crombie AL, Violin JD, Yamashita DS. Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain. Journal of Medicinal Chemistry. 56: 8019-31. PMID 24063433 DOI: 10.1021/jm4010829  0.64
2013 DeWire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, Chen XT, Pitis PM, Gotchev D, Yuan C, Koblish M, Lark MW, Violin JD. A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. The Journal of Pharmacology and Experimental Therapeutics. 344: 708-17. PMID 23300227 DOI: 10.1124/jpet.112.201616  0.64
2011 DeWire SM, Violin JD. Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology. Circulation Research. 109: 205-16. PMID 21737816 DOI: 10.1161/CIRCRESAHA.110.231308  0.64
2011 Rajagopal S, Ahn S, Rominger DH, Gowen-MacDonald W, Lam CM, Dewire SM, Violin JD, Lefkowitz RJ. Quantifying ligand bias at seven-transmembrane receptors. Molecular Pharmacology. 80: 367-77. PMID 21610196 DOI: 10.1124/mol.111.072801  0.64
2010 Violin JD, DeWire SM, Yamashita D, Rominger DH, Nguyen L, Schiller K, Whalen EJ, Gowen M, Lark MW. Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance. The Journal of Pharmacology and Experimental Therapeutics. 335: 572-9. PMID 20801892 DOI: 10.1124/jpet.110.173005  0.64
2009 Walters RW, Shukla AK, Kovacs JJ, Violin JD, DeWire SM, Lam CM, Chen JR, Muehlbauer MJ, Whalen EJ, Lefkowitz RJ. beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. The Journal of Clinical Investigation. 119: 1312-21. PMID 19349687 DOI: 10.1172/JCI36806  0.64
2008 Kim J, Zhang L, Peppel K, Wu JH, Zidar DA, Brian L, DeWire SM, Exum ST, Lefkowitz RJ, Freedman NJ. Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. Circulation Research. 103: 70-9. PMID 18519945 DOI: 10.1161/CIRCRESAHA.108.172338  0.64
2008 DeWire SM, Kim J, Whalen EJ, Ahn S, Chen M, Lefkowitz RJ. Beta-arrestin-mediated signaling regulates protein synthesis. The Journal of Biological Chemistry. 283: 10611-20. PMID 18276584 DOI: 10.1074/jbc.M710515200  0.64
2007 Wisler JW, DeWire SM, Whalen EJ, Violin JD, Drake MT, Ahn S, Shenoy SK, Lefkowitz RJ. A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 16657-62. PMID 17925438 DOI: 10.1073/pnas.0707936104  0.64
2007 DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK. Beta-arrestins and cell signaling. Annual Review of Physiology. 69: 483-510. PMID 17305471 DOI: 10.1146/annurev.physiol.69.022405.154749  0.64
2006 Violin JD, Dewire SM, Barnes WG, Lefkowitz RJ. G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics. The Journal of Biological Chemistry. 281: 36411-9. PMID 17008309 DOI: 10.1074/jbc.M607956200  0.64
2005 Dittmer DP, Gonzalez CM, Vahrson W, DeWire SM, Hines-Boykin R, Damania B. Whole-genome transcription profiling of rhesus monkey rhadinovirus. Journal of Virology. 79: 8637-50. PMID 15956606 DOI: 10.1128/JVI.79.13.8637-8650.2005  1
2005 DeWire SM, Damania B. The latency-associated nuclear antigen of rhesus monkey rhadinovirus inhibits viral replication through repression of Orf50/Rta transcriptional activation. Journal of Virology. 79: 3127-38. PMID 15709032 DOI: 10.1128/JVI.79.5.3127-3138.2005  1
2004 Damania B, Jeong JH, Bowser BS, DeWire SM, Staudt MR, Dittmer DP. Comparison of the Rta/Orf50 transactivator proteins of gamma-2-herpesviruses. Journal of Virology. 78: 5491-9. PMID 15113928 DOI: 10.1128/JVI.78.10.5491-5499.2004  1
2004 Wang L, Wakisaka N, Tomlinson CC, DeWire SM, Krall S, Pagano JS, Damania B. The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) K1 protein induces expression of angiogenic and invasion factors. Cancer Research. 64: 2774-81. PMID 15087393 DOI: 10.1158/0008-5472.CAN-03-3653  1
2003 DeWire SM, Money ES, Krall SP, Damania B. Rhesus monkey rhadinovirus (RRV): construction of a RRV-GFP recombinant virus and development of assays to assess viral replication. Virology. 312: 122-34. PMID 12890626 DOI: 10.1016/S0042-6822(03)00195-8  1
2002 Bowser BS, DeWire SM, Damania B. Transcriptional regulation of the K1 gene product of Kaposi's sarcoma-associated herpesvirus. Journal of Virology. 76: 12574-83. PMID 12438583 DOI: 10.1128/JVI.76.24.12574-12583.2002  1
2002 DeWire SM, McVoy MA, Damania B. Kinetics of expression of rhesus monkey rhadinovirus (RRV) and identification and characterization of a polycistronic transcript encoding the RRV Orf50/Rta, RRV R8, and R8.1 genes. Journal of Virology. 76: 9819-31. PMID 12208960 DOI: 10.1128/JVI.76.19.9819-9831.2002  1
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