Aadra P. Bhatt, Ph.D. - Related publications

2013 Microbiology & Immunology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Microbiology Biology, Virology Biology, Biochemistry
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Chen L, Xiao D, Tang F, Gao H, Li X. CAPN6 in disease: An emerging therapeutic target (Review). International Journal of Molecular Medicine. 46: 1644-1652. PMID 33000175 DOI: 10.3892/ijmm.2020.4734   
2020 Zang YQ, Zhai YQ, Feng YY, Ju XY, Zuo F. Molecular mechanisms of quinalizarin induces apoptosis and G0/G1 cell cycle of human esophageal cancer HCE-4 cells depends on MAPK, STAT3, and NF-κB signaling pathways. Environmental Toxicology. PMID 33030807 DOI: 10.1002/tox.23033   
2020 Corcino De La Cena KO, Xi-Yeen Ho R, Amraei R, Woolf N, Tashjian JY, Zhao Q, Richards S, Walker J, Huang J, Chitalia V, Rahimi N. Transmembrane and immunoglobulin domain containing1 (TMIGD1), a putative tumor suppressor, induces G2-M cell cycle checkpoint arrest in colon cancer cells. The American Journal of Pathology. PMID 33129760 DOI: 10.1016/j.ajpath.2020.09.015   
2020 Ward AB, Keeton AB, Chen X, Mattox TE, Coley AB, Maxuitenko YY, Buchsbaum DJ, Randall TD, Zhou G, Piazza GA. Enhancing anticancer activity of checkpoint immunotherapy by targeting RAS. Medcomm. 1: 121-128. PMID 33073260 DOI: 10.1002/mco2.10   
2020 Prabhu VV, Morrow S, Rahman Kawakibi A, Zhou L, Ralff M, Ray J, Jhaveri A, Ferrarini I, Lee Y, Parker C, Zhang Y, Borsuk R, Chang WI, Honeyman JN, Tavora F, et al. ONC201 and imipridones: Anti-cancer compounds with clinical efficacy. Neoplasia (New York, N.Y.). 22: 725-744. PMID 33142238 DOI: 10.1016/j.neo.2020.09.005   
2020 Li F, Kozono D, Deraska P, Branigan T, Dunn C, Zheng XF, Parmar K, Nguyen H, DeCaprio J, Shapiro GI, Chowdhury D, D'Andrea AD. CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress. Molecular Cell. PMID 33108758 DOI: 10.1016/j.molcel.2020.10.008   
2020 Zhang J. Targeting mTOR by CZ415 Suppresses Cell Proliferation and Promotes Apoptosis via Lipin-1 in Cervical Cancer In Vitro and In Vivo. Reproductive Sciences (Thousand Oaks, Calif.). PMID 32944878 DOI: 10.1007/s43032-020-00313-4   
2020 Lei W, Huo Z. Jervine inhibits non-small cell lung cancer (NSCLC) progression by suppressing Hedgehog and AKT signaling via triggering autophagy-regulated apoptosis. Biochemical and Biophysical Research Communications. PMID 32972750 DOI: 10.1016/j.bbrc.2020.08.023   
2020 Joo MK, Shin S, Ye DJ, An HG, Kwon TU, Baek HS, Kwon YJ, Chun YJ. Combined treatment with auranofin and trametinib induces synergistic apoptosis in breast cancer cells. Journal of Toxicology and Environmental Health. Part A. 1-11. PMID 33103613 DOI: 10.1080/15287394.2020.1835762   
2020 Punt S, Malu S, McKenzie JA, Manrique SZ, Doorduijn EM, Mbofung RM, Williams L, Silverman DA, Ashkin EL, Dominguez AL, Wang Z, Chen JQ, Maiti SN, Tieu TN, Liu C, et al. Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity. Cancer Immunology, Immunotherapy : Cii. PMID 33123754 DOI: 10.1007/s00262-020-02748-9   
2020 Ma X, Wu K, Xu A, Jiao P, Li H, Xing L. The sesquiterpene lactone eupatolide induces apoptosis in non-small cell lung cancer cells by suppressing STAT3 signaling. Environmental Toxicology and Pharmacology. 103513. PMID 33091599 DOI: 10.1016/j.etap.2020.103513   
2020 Remer E, Badarni M, Hikri E, Dayan A, Levi L, Popovtzer A, Iraqi M, Porgador A, Joshua BZ, Bachar G, Elkabets M, Scaltriti M, Mizrachi A. CDK 4/6 Inhibition Overcomes Acquired and Inherent Resistance to PI3Kα Inhibition in Pre-Clinical Models of Head and Neck Squamous Cell Carcinoma. Journal of Clinical Medicine. 9. PMID 33036331 DOI: 10.3390/jcm9103214   
2020 Saqub H, Proetsch-Gugerbauer H, Bezrookove V, Nosrati M, Vaquero EM, de Semir D, Ice RJ, McAllister S, Soroceanu L, Kashani-Sabet M, Osorio R, Dar AA. Dinaciclib, a cyclin-dependent kinase inhibitor, suppresses cholangiocarcinoma growth by targeting CDK2/5/9. Scientific Reports. 10: 18489. PMID 33116269 DOI: 10.1038/s41598-020-75578-5   
2020 Lim EY, Park J, Kim YT, Kim MJ. Imipramine Inhibits Migration and Invasion in Metastatic Castration-Resistant Prostate Cancer PC-3 Cells via AKT-Mediated NF-κB Signaling Pathway. Molecules (Basel, Switzerland). 25. PMID 33050597 DOI: 10.3390/molecules25204619   
2020 Cui Y, Zhou J, Rong F. Combination of metformin and RG7388 enhances inhibition of growth and induction of apoptosis of ovarian cancer cells through the PI3K/AKT/mTOR pathway. Biochemical and Biophysical Research Communications. PMID 33051060 DOI: 10.1016/j.bbrc.2020.09.135   
2020 Corso CR, Stipp MC, Radulski DR, Mariott M, da Silva LM, de Souza Ramos EA, Klassen G, Queiroz Telles JE, Oliveira CS, Stefanello MÉA, Verhoeven AJ, Oude Elferink RPJ, Acco A. Fruticuline A, a chemically-defined diterpene, exerts antineoplastic effects in vitro and in vivo by multiple mechanisms. Scientific Reports. 10: 16477. PMID 33020521 DOI: 10.1038/s41598-020-73432-2   
2020 Zhang Y, VanHecke GC, Ahn YH, Proby CM, Dinkova-Kostova AT. Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells. European Journal of Pharmacology. 173609. PMID 33031796 DOI: 10.1016/j.ejphar.2020.173609   
2020 Sun X, Xu Q, Zeng L, Xie L, Zhao Q, Xu H, Wang X, Jiang N, Fu P, Sang M. Resveratrol suppresses the growth and metastatic potential of cervical cancer by inhibiting STAT3 phosphorylation. Cancer Medicine. PMID 33040485 DOI: 10.1002/cam4.3510   
2020 Sharma C, Yang W, Steen H, Freeman MR, Hemler ME. Antioxidant functions of DHHC3 suppress anti-cancer drug activities. Cellular and Molecular Life Sciences : Cmls. PMID 32986127 DOI: 10.1007/s00018-020-03635-3   
2020 Amen T, Kaganovich D. Fasnall Induces Atypically Transient Stress Granules Independently of FASN Inhibition. Iscience. 23: 101550. PMID 33083719 DOI: 10.1016/j.isci.2020.101550   
2020 Burgess JT, Bolderson E, Adams MN, Duijf PHG, Zhang SD, Gray SG, Wright G, Richard DJ, O'Byrne KJ. SASH1 is a prognostic indicator and potential therapeutic target in non-small cell lung cancer. Scientific Reports. 10: 18605. PMID 33122723 DOI: 10.1038/s41598-020-75625-1   
2020 Gao J, Luo T, Lin N, Zhang S, Wang J. A New Tool for CRISPR-Cas13a-Based Cancer Gene Therapy. Molecular Therapy Oncolytics. 19: 79-92. PMID 33102691 DOI: 10.1016/j.omto.2020.09.004   
2020 Al-Rashed F, Thomas R, Al-Roub A, Al-Mulla F, Ahmad R. LPS Induces GM-CSF Production by Breast Cancer MDA-MB-231 Cells via Long-Chain Acyl-CoA Synthetase 1. Molecules (Basel, Switzerland). 25. PMID 33066575 DOI: 10.3390/molecules25204709   
2020 Beauchamp E, Yap MC, Iyer A, Perinpanayagam MA, Gamma JM, Vincent KM, Lakshmanan M, Raju A, Tergaonkar V, Tan SY, Lim ST, Dong WF, Postovit LM, Read KD, Gray DW, et al. Targeting N-myristoylation for therapy of B-cell lymphomas. Nature Communications. 11: 5348. PMID 33093447 DOI: 10.1038/s41467-020-18998-1   
2020 Lim WF, Mohamad Yusof MI, Teh LK, Salleh MZ. Significant Decreased Expressions of CaN, VEGF, SLC39A6 and SFRP1 in MDA-MB-231 Xenograft Breast Tumor Mice Treated with Leaves and Seed Residue (MOLSr) Extracts. Nutrients. 12. PMID 33007803 DOI: 10.3390/nu12102993   
2020 Lim WF, Mohamad Yusof MI, Teh LK, Salleh MZ. Significant Decreased Expressions of CaN, VEGF, SLC39A6 and SFRP1 in MDA-MB-231 Xenograft Breast Tumor Mice Treated with Leaves and Seed Residue (MOLSr) Extracts. Nutrients. 12. PMID 33007803 DOI: 10.3390/nu12102993   
2020 Li B, Li Y, Tomkiewicz-Raulet C, Dao P, Lietha D, Yen-Pon E, Du Z, Coumoul X, Garbay C, Etheve-Quelquejeu M, Chen H. Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma. Journal of Medicinal Chemistry. PMID 33119295 DOI: 10.1021/acs.jmedchem.0c01059   
2020 Li B, Li Y, Tomkiewicz-Raulet C, Dao P, Lietha D, Yen-Pon E, Du Z, Coumoul X, Garbay C, Etheve-Quelquejeu M, Chen H. Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma. Journal of Medicinal Chemistry. PMID 33119295 DOI: 10.1021/acs.jmedchem.0c01059   
2020 Abusarah J, Cui Y, El-Hachem N, El-Kadiry AE, Hammond-Martel I, Wurtele H, Beaudry A, Raynal NJ, Robert F, Pelletier J, Jankovic M, Mercier F, Kamyabiazar S, Annabi B, Rafei M. TACIMA-218: A NOVEL PRO-OXIDANT AGENT EXHIBITING SELECTIVE ANTI-TUMORAL ACTIVITY. Molecular Cancer Therapeutics. PMID 33087510 DOI: 10.1158/1535-7163.MCT-20-0333   
2020 Buyandelger B, Bar EE, Hung KS, Chen RM, Chiang YH, Liou JP, Huang HM, Wang JY. Histone deacetylase inhibitor MPT0B291 suppresses Glioma Growth and partially through acetylation of p53. International Journal of Biological Sciences. 16: 3184-3199. PMID 33162824 DOI: 10.7150/ijbs.45505   
2020 Arczewska KD, Krasuska W, Stachurska A, Karpińska K, Sikorska J, Kiedrowski M, Lange D, Stępień T, Czarnocka B. hMTH1 and GPX1 expression in human thyroid tissue is interrelated to prevent oxidative DNA damage. Dna Repair. 95: 102954. PMID 32877752 DOI: 10.1016/j.dnarep.2020.102954   
2020 Pang W, Li Y, Guo W, Shen H. Cyclin E: a potential treatment target to reverse cancer chemoresistance by regulating the cell cycle. American Journal of Translational Research. 12: 5170-5187. PMID 33042412   
2020 Choi C, Cho Y, Son A, Shin SW, Lee YJ, Park HC. Therapeutic Potential of (-)-Agelamide D, a Diterpene Alkaloid from the Marine Sponge sp., as a Natural Radiosensitizer in Hepatocellular Carcinoma Models. Marine Drugs. 18. PMID 33003597 DOI: 10.3390/md18100500   
2020 Yoon HJ, Surh YJ. Modulation of Cancer Cell Growth and Progression by Caveolin-1 in the Tumor Microenvironment. Advances in Experimental Medicine and Biology. 1277: 63-74. PMID 33119865 DOI: 10.1007/978-3-030-50224-9_4   
2020 Liu J, Liu Y, Zhang J, Liu D, Bao Y, Chen T, Tang T, Lin J, Luo Y, Jin Y, Zhang J. Indole hydrazide compound ZJQ-24 inhibits angiogenesis and induces apoptosis cell death through abrogation of AKT/mTOR pathway in hepatocellular carcinoma. Cell Death & Disease. 11: 926. PMID 33116125 DOI: 10.1038/s41419-020-03108-2   
2020 Li J, Zhu Y. Recent Advances in Liver Cancer Stem Cells: Non-coding RNAs, Oncogenes and Oncoproteins. Frontiers in Cell and Developmental Biology. 8: 548335. PMID 33117795 DOI: 10.3389/fcell.2020.548335   
2020 Derakhshani A, Silvestris N, Hemmat N, Asadzadeh Z, Abdoli Shadbad M, Nourbakhsh NS, Mobasheri L, Vahedi P, Shahmirzaie M, Brunetti O, Safarpour H, Baradaran B. Targeting TGF-β-Mediated SMAD Signaling Pathway via Novel Recombinant Cytotoxin II: A Potent Protein from Venom in Melanoma. Molecules (Basel, Switzerland). 25. PMID 33167431 DOI: 10.3390/molecules25215148   
2020 Ernst A, Hennel R, Krombach J, Kapfhammer H, Brix N, Zuchtriegel G, Uhl B, Reichel CA, Frey B, Gaipl US, Winssinger N, Shirasawa S, Sasazuki T, Sperandio M, Belka C, et al. Priming of Anti-tumor Immune Mechanisms by Radiotherapy Is Augmented by Inhibition of Heat Shock Protein 90. Frontiers in Oncology. 10: 1668. PMID 32984042 DOI: 10.3389/fonc.2020.01668   
2020 Feng B, Zhao C, Li J, Yu J, Zhang Y, Zhang X, Tian T, Zhao L. The Novel Synthetic Triterpene Methyl 3β-O-[4-(2-Aminoethylamino)-4-oxo-butyryl]olean-12-ene-28-oate Inhibits Breast Tumor Cell Growth in Vitro and in Vivo. Chemical & Pharmaceutical Bulletin. 68: 962-970. PMID 32999148 DOI: 10.1248/cpb.c20-00353   
2020 Zhao YY, Jia J, Zhang JJ, Xun YP, Xie SJ, Liang JF, Guo HG, Zhu JZ, Ma SL, Zhang SR. Inhibition of histamine receptor H3 suppresses the growth and metastasis of human non-small cell lung cancer cells via inhibiting PI3K/Akt/mTOR and MEK/ERK signaling pathways and blocking EMT. Acta Pharmacologica Sinica. PMID 33159174 DOI: 10.1038/s41401-020-00548-6   
2020 Dos Santos DC, Rafique J, Saba S, Almeida GM, Siminski T, Pádua C, Filho DW, Zamoner A, Braga AL, Pedrosa RC, Ourique F. Apoptosis oxidative damage-mediated and antiproliferative effect of selenylated imidazo[1,2-a]pyridines on hepatocellular carcinoma HepG2 cells and in vivo. Journal of Biochemical and Molecular Toxicology. e22663. PMID 33125183 DOI: 10.1002/jbt.22663   
2020 Kinker GS, Greenwald AC, Tal R, Orlova Z, Cuoco MS, McFarland JM, Warren A, Rodman C, Roth JA, Bender SA, Kumar B, Rocco JW, Fernandes PACM, Mader CC, Keren-Shaul H, et al. Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity. Nature Genetics. 52: 1208-1218. PMID 33128048 DOI: 10.1038/s41588-020-00726-6   
2020 Jiang M, Qi L, Li L, Li Y. The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer. Cell Death Discovery. 6: 112. PMID 33133646 DOI: 10.1038/s41420-020-00349-0   
2020 Perez RE, Calhoun S, Shim D, Levenson VV, Duan L, Maki CG. Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and tumor growth of triple-negative breast cancer. Cancer Biology & Therapy. 1-8. PMID 33044914 DOI: 10.1080/15384047.2020.1824989   
2020 Wang JH, Lu TJ, Kung ML, Yang YF, Yeh CY, Tu YT, Chen WS, Tsai KW. The Long Noncoding RNA LOC441461 (STX17-AS1) Modulates Colorectal Cancer Cell Growth and Motility. Cancers. 12. PMID 33126743 DOI: 10.3390/cancers12113171   
2020 Barnoud T, Leung JC, Leu JI, Basu S, Poli ANR, Parris JLD, Indeglia A, Martynyuk T, Good M, Gnanapradeepan K, Sanseviero E, Moeller R, Tang HY, Cassel J, Kossenkov AV, et al. A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors. Cancer Research. PMID 33023943 DOI: 10.1158/0008-5472.CAN-20-0397   
2020 Espinosa-Sánchez A, Suárez-Martínez E, Sánchez-Díaz L, Carnero A. Therapeutic Targeting of Signaling Pathways Related to Cancer Stemness. Frontiers in Oncology. 10: 1533. PMID 32984007 DOI: 10.3389/fonc.2020.01533   
2020 Li J, Chen CY, Huang JY, Wang L, Xu Z, Kang W, Lin MH, Wang HD. Isokotomolide A from Cinnamomum kotoense Induce Melanoma Autophagy and Apoptosis and . Oxidative Medicine and Cellular Longevity. 2020: 3425147. PMID 33062137 DOI: 10.1155/2020/3425147   
2020 Merisaari J, Denisova OV, Doroszko M, Le Joncour V, Johansson P, Leenders WPJ, Kastrinsky DB, Zaware N, Narla G, Laakkonen P, Nelander S, Ohlmeyer M, Westermarck J. Monotherapy efficacy of blood-brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma. Brain Communications. 2: fcaa002. PMID 32954276 DOI: 10.1093/braincomms/fcaa002   
2020 Ni H, Ji D, Huang Z, Li J. SMAGP knockdown inhibits the malignant phenotypes of glioblastoma cells by inactivating the PI3K/Akt pathway. Archives of Biochemistry and Biophysics. 108628. PMID 33049294 DOI: 10.1016/j.abb.2020.108628