Jonathan C. Kagan, Ph.D. - Publications

2003 Yale University, New Haven, CT 
Microbiology Biology, Cell Biology, Genetics, Molecular Biology

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, ... ... Kagan JC, et al. Control of the innate immune response by the mevalonate pathway. Nature Immunology. PMID 27270400 DOI: 10.1038/Ni.3487  0.96
2016 Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado CA, Shao F, Wu H, Springstead JR, Kagan JC. An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science (New York, N.Y.). PMID 27103670 DOI: 10.1126/Science.Aaf3036  0.96
2015 Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Philip NH, Brodsky IE, Mecsas J, Kagan JC. A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4. Cell Host & Microbe. 18: 682-93. PMID 26651944 DOI: 10.1016/J.Chom.2015.11.006  0.96
2015 Tan Y, Zanoni I, Cullen TW, Goodman AL, Kagan JC. Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria. Immunity. PMID 26546281 DOI: 10.1016/J.Immuni.2015.10.008  0.96
2015 Rajaiah R, Perkins DJ, Ireland DD, Vogel SN. CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance. Proceedings of the National Academy of Sciences of the United States of America. 112: 8391-6. PMID 26106158 DOI: 10.1073/Pnas.1424980112  0.96
2015 Chow J, Franz KM, Kagan JC. PRRs are watching you: Localization of innate sensing and signaling regulators. Virology. 479: 104-9. PMID 25800355 DOI: 10.1016/J.Virol.2015.02.051  0.96
2015 Odendall C, Kagan JC. The unique regulation and functions of type III interferons in antiviral immunity. Current Opinion in Virology. 12: 47-52. PMID 25771505 DOI: 10.1016/J.Coviro.2015.02.003  0.96
2015 Rosadini CV, Kagan JC. Microbial strategies for antagonizing Toll-like-receptor signal transduction. Current Opinion in Immunology. 32: 61-70. PMID 25615700 DOI: 10.1016/J.Coi.2014.12.011  0.96
2015 Brubaker SW, Bonham KS, Zanoni I, Kagan JC. Innate immune pattern recognition: a cell biological perspective. Annual Review of Immunology. 33: 257-90. PMID 25581309 DOI: 10.1146/Annurev-Immunol-032414-112240  0.96
2015 Kagan JC, Barton GM. Emerging principles governing signal transduction by pattern-recognition receptors. Cold Spring Harbor Perspectives in Biology. 7: a016253. PMID 25395297 DOI: 10.1101/Cshperspect.A016253  0.96
2014 Kagan JC, Magupalli VG, Wu H. SMOCs: supramolecular organizing centres that control innate immunity. Nature Reviews. Immunology. 14: 821-6. PMID 25359439 DOI: 10.1038/Nri3757  0.01
2014 Kagan JC. Common mechanisms activate plant guard receptors and TLR4. Trends in Immunology. 35: 454-6. PMID 25224694 DOI: 10.1016/J.It.2014.08.009  0.96
2014 Teigler JE, Kagan JC, Barouch DH. Late endosomal trafficking of alternative serotype adenovirus vaccine vectors augments antiviral innate immunity. Journal of Virology. 88: 10354-63. PMID 24991003 DOI: 10.1128/Jvi.00936-14  0.96
2014 Gwadz M, Cleland CM, Belkin M, Ritchie A, Leonard N, Riedel M, Banfield A, Colon P, Elharrar V, Kagan J, Mildvan D. ACT2 peer-driven intervention increases enrollment into HIV/AIDS medical studies among African Americans/Blacks and Hispanics: A cluster randomized controlled trial. Aids and Behavior. 18: 2409-22. PMID 24961193 DOI: 10.1007/S10461-014-0829-5  0.01
2014 Odendall C, Dixit E, Stavru F, Bierne H, Franz KM, Durbin AF, Boulant S, Gehrke L, Cossart P, Kagan JC. Diverse intracellular pathogens activate type III interferon expression from peroxisomes. Nature Immunology. 15: 717-26. PMID 24952503 DOI: 10.1038/Ni.2915  0.96
2014 Bonham KS, Kagan JC. Endosomes as platforms for NOD-like receptor signaling. Cell Host & Microbe. 15: 523-5. PMID 24832447 DOI: 10.1016/J.Chom.2014.05.001  0.96
2014 Tan Y, Kagan JC. A cross-disciplinary perspective on the innate immune responses to bacterial lipopolysaccharide. Molecular Cell. 54: 212-23. PMID 24766885 DOI: 10.1016/J.Molcel.2014.03.012  0.96
2014 Brubaker SW, Gauthier AE, Mills EW, Ingolia NT, Kagan JC. A bicistronic MAVS transcript highlights a class of truncated variants in antiviral immunity. Cell. 156: 800-11. PMID 24529381 DOI: 10.1016/J.Cell.2014.01.021  0.96
2014 Bonham KS, Orzalli MH, Hayashi K, Wolf AI, Glanemann C, Weninger W, Iwasaki A, Knipe DM, Kagan JC. A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction. Cell. 156: 705-16. PMID 24529375 DOI: 10.1016/J.Cell.2014.01.019  0.96
2014 Franz KM, Kagan JC. Finding a needle in a haystack of needles - a productive hunt for interferon stimulated genes with antiviral activity. Immunology and Cell Biology. 92: 205-7. PMID 24418815 DOI: 10.1038/Icb.2013.108  0.96
2014 Al-Shahi Salman R, Beller E, Kagan J, Hemminki E, Phillips RS, Savulescu J, Macleod M, Wisely J, Chalmers I. Increasing value and reducing waste in biomedical research regulation and management. Lancet. 383: 176-85. PMID 24411646 DOI: 10.1016/S0140-6736(13)62297-7  0.01
2013 Kagan JC. Immunology. Sensing endotoxins from within. Science (New York, N.Y.). 341: 1184-5. PMID 24031006 DOI: 10.1126/Science.1243939  0.96
2013 Kagan JC. Recognition for an innate explorer. Cell. 154: 261-4. PMID 23870114 DOI: 10.1016/J.Cell.2013.06.047  0.96
2013 Kagan JC, Horng T. NLRP3 inflammasome activation: CD36 serves double duty. Nature Immunology. 14: 772-4. PMID 23867926 DOI: 10.1038/Ni.2668  0.96
2013 Odendall C, Kagan JC. Peroxisomes and the antiviral responses of mammalian cells. Sub-Cellular Biochemistry. 69: 67-75. PMID 23821143 DOI: 10.1007/978-94-007-6889-5_4  0.96
2013 Cho JA, Lee AH, Platzer B, Cross BC, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host & Microbe. 13: 558-69. PMID 23684307 DOI: 10.1016/J.Chom.2013.03.011  0.96
2013 Dixit E, Kagan JC. Intracellular pathogen detection by RIG-I-like receptors. Advances in Immunology. 117: 99-125. PMID 23611287 DOI: 10.1016/B978-0-12-410524-9.00004-9  0.96
2012 Kagan JC. Signaling organelles of the innate immune system. Cell. 151: 1168-78. PMID 23217704 DOI: 10.1016/J.Cell.2012.11.011  0.96
2012 Velupillai P, Sung CK, Andrews E, Moran J, Beier D, Kagan J, Benjamin T. Polymorphisms in toll-like receptor 4 underlie susceptibility to tumor induction by the mouse polyomavirus. Journal of Virology. 86: 11541-7. PMID 22896604 DOI: 10.1128/Jvi.01614-12  0.96
2012 Kagan JC. Defining the subcellular sites of innate immune signal transduction. Trends in Immunology. 33: 442-8. PMID 22817912 DOI: 10.1016/J.It.2012.06.005  0.96
2012 Kagan JC, Iwasaki A. Phagosome as the organelle linking innate and adaptive immunity. Traffic (Copenhagen, Denmark). 13: 1053-61. PMID 22577865 DOI: 10.1111/J.1600-0854.2012.01377.X  0.96
2012 Marek LR, Kagan JC. Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila. Immunity. 36: 612-22. PMID 22464168 DOI: 10.1016/J.Immuni.2012.01.019  0.96
2012 Edison N, Zuri D, Maniv I, Bornstein B, Lev T, Gottfried Y, Kemeny S, Garcia-Fernandez M, Kagan J, Larisch S. The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo. Cell Death and Differentiation. 19: 356-68. PMID 21869827 DOI: 10.1038/Cdd.2011.112  0.96
2011 Zanoni I, Ostuni R, Marek LR, Barresi S, Barbalat R, Barton GM, Granucci F, Kagan JC. CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell. 147: 868-80. PMID 22078883 DOI: 10.1016/J.Cell.2011.09.051  0.96
2011 Wang S, Villablanca EJ, De Calisto J, Gomes DC, Nguyen DD, Mizoguchi E, Kagan JC, Reinecker HC, Hacohen N, Nagler C, Xavier RJ, Rossi-Bergmann B, Chen YB, Blomhoff R, Snapper SB, et al. MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. Journal of Immunology (Baltimore, Md. : 1950). 187: 141-50. PMID 21646294 DOI: 10.4049/Jimmunol.1003740  0.96
2011 Marek LR, Kagan JC. Deciphering the function of nucleic acid sensing TLRs one regulatory step at a time. Frontiers in Bioscience (Landmark Edition). 16: 2060-8. PMID 21622162 DOI: 10.2741/3839  0.96
2011 Wang L, Trebicka E, Fu Y, Waggoner L, Akira S, Fitzgerald KA, Kagan JC, Cherayil BJ. Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM. Journal of Innate Immunity. 3: 437-46. PMID 21494017 DOI: 10.1159/000324833  0.96
2011 Liao AP, Salajegheh M, Nazareno R, Kagan JC, Jubin RG, Greenberg SA. Interferon β is associated with type 1 interferon-inducible gene expression in dermatomyositis. Annals of the Rheumatic Diseases. 70: 831-6. PMID 21177291 DOI: 10.1136/ard.2010.139949  0.96
2010 Kagan JC. Recycling endosomes and TLR signaling--the Rab11 GTPase leads the way. Immunity. 33: 578-80. PMID 21029967 DOI: 10.1016/J.Immuni.2010.10.003  0.96
2010 Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC. Peroxisomes are signaling platforms for antiviral innate immunity. Cell. 141: 668-81. PMID 20451243 DOI: 10.1016/J.Cell.2010.04.018  0.96
2010 Kagan JC. "Complementing" toll signaling. Science Signaling. 3: pe15. PMID 20442416 DOI: 10.1126/Scisignal.3120Pe15  0.96
2009 Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ. Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. The Journal of Clinical Investigation. 119: 3322-8. PMID 19809161 DOI: 10.1172/Jci39939  0.96
2009 Barton GM, Kagan JC. A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nature Reviews. Immunology. 9: 535-42. PMID 19556980 DOI: 10.1038/Nri2587  0.96
2008 Kagan JC, Su T, Horng T, Chow A, Akira S, Medzhitov R. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nature Immunology. 9: 361-8. PMID 18297073 DOI: 10.1038/Ni1569  0.96
2006 Kagan JC, Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell. 125: 943-55. PMID 16751103 DOI: 10.1016/J.Cell.2006.03.047  0.96
2006 Barton GM, Kagan JC, Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nature Immunology. 7: 49-56. PMID 16341217 DOI: 10.1038/Ni1280  0.96
2005 Kagan JC, Murata T, Roy CR. Analysis of Rab1 recruitment to vacuoles containing Legionella pneumophila. Methods in Enzymology. 403: 71-81. PMID 16473578 DOI: 10.1016/S0076-6879(05)03007-7  0.96
2005 Lambert JS, Moye J, Plaeger SF, Stiehm ER, Bethel J, Mofenson LM, Mathieson B, Kagan J, Rosenblatt H, Paxton H, Suter H, Landay A. Association of selected phenotypic markers of lymphocyte activation and differentiation with perinatal human immunodeficiency virus transmission and infant infection. Clinical and Diagnostic Laboratory Immunology. 12: 622-31. PMID 15879023 DOI: 10.1128/Cdli.12.5.622-631.2005  0.01
2005 Mildvan D, Spritzler J, Grossberg SE, Fahey JL, Johnston DM, Schock BR, Kagan J. Serum neopterin, an immune activation marker, independently predicts disease progression in advanced HIV-1 infection. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 40: 853-8. PMID 15736019 DOI: 10.1086/427877  0.01
2005 Nagai H, Cambronne ED, Kagan JC, Amor JC, Kahn RA, Roy CR. A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 826-31. PMID 15613486 DOI: 10.1073/Pnas.0406239101  0.96
2004 Mildvan D, Bosch RJ, Kim RS, Spritzler J, Haas DW, Kuritzkes D, Kagan J, Nokta M, DeGruttola V, Moreno M, Landay A. Immunophenotypic markers and antiretroviral therapy (IMART): T cell activation and maturation help predict treatment response. The Journal of Infectious Diseases. 189: 1811-20. PMID 15122517 DOI: 10.1086/383277  0.01
2004 Kagan JC, Stein MP, Pypaert M, Roy CR. Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle. The Journal of Experimental Medicine. 199: 1201-11. PMID 15117975 DOI: 10.1084/Jem.20031706  0.96
2004 Guignot J, Caron E, Beuzón C, Bucci C, Kagan J, Roy C, Holden DW. Microtubule motors control membrane dynamics of Salmonella-containing vacuoles. Journal of Cell Science. 117: 1033-45. PMID 14970261 DOI: 10.1242/Jcs.00949  0.01
2003 Spritzler J, Mildvan D, Russo A, Asthana D, Livnat D, Schock B, Kagan J, Landay A, Haas DW. Can immune markers predict subsequent discordance between immunologic and virologic responses to antiretroviral therapy? Adult AIDS Clinical Trials Group. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 37: 551-8. PMID 12905140 DOI: 10.1086/376986  0.01
2002 Kagan JC, Roy CR. Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites. Nature Cell Biology. 4: 945-54. PMID 12447391 DOI: 10.1038/Ncb883  0.96
2002 Nagai H, Kagan JC, Zhu X, Kahn RA, Roy CR. A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes. Science (New York, N.Y.). 295: 679-82. PMID 11809974 DOI: 10.1126/Science.1067025  0.96
2000 Coers J, Kagan JC, Matthews M, Nagai H, Zuckman DM, Roy CR. Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth. Molecular Microbiology. 38: 719-36. PMID 11115108 DOI: 10.1046/J.1365-2958.2000.02176.X  0.96
1997 Mildvan D, Landay A, De Gruttola V, Machado SG, Kagan J. An approach to the validation of markers for use in AIDS clinical trials. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 24: 764-74. PMID 9142767 DOI: 10.1093/Clinids/24.5.764  0.01
1996 Nicholson J, Kidd P, Mandy F, Livnat D, Kagan J. Three-color supplement to the NIAID DAIDS guideline for flow cytometric immunophenotyping. Cytometry. 26: 227-30. PMID 8889396 DOI: 10.1002/(Sici)1097-0320(19960915)26:3<227::Aid-Cyto8>3.0.Co;2-B  0.01
1996 Valentine FT, Kundu S, Haslett PA, Katzenstein D, Beckett L, Spino C, Borucki M, Vasquez M, Smith G, Korvick J, Kagan J, Merigan TC. A randomized, placebo-controlled study of the immunogenicity of human immunodeficiency virus (HIV) rgp160 vaccine in HIV-infected subjects with > or = 400/mm3 CD4 T lymphocytes (AIDS Clinical Trials Group Protocol 137). The Journal of Infectious Diseases. 173: 1336-46. PMID 8648205 DOI: 10.1093/Infdis/173.6.1336  0.01
1995 Connelly MC, Knight M, Giorgi JV, Kagan J, Landay AL, Parker JW, Page E, Spino C, Wilkening C, Mercolino TJ. Standardization of absolute CD4+ lymphocyte counts across laboratories: an evaluation of the Ortho CytoronAbsolute flow cytometry system on normal donors. Cytometry. 22: 200-10. PMID 8556951 DOI: 10.1002/Cyto.990220307  0.01
1993 Kagan J, Gelman R, Waxdal M, Kidd P. NIAID Division of AIDS flow cytometry quality assessment program. Annals of the New York Academy of Sciences. 677: 50-2. PMID 8494245 DOI: 10.1111/J.1749-6632.1993.Tb38763.X  0.01
1993 Calvelli T, Denny TN, Paxton H, Gelman R, Kagan J. Guideline for flow cytometric immunophenotyping: a report from the National Institute of Allergy and Infectious Diseases, Division of AIDS. Cytometry. 14: 702-15. PMID 8243200 DOI: 10.1002/Cyto.990140703  0.01
1993 Gelman R, Cheng SC, Kidd P, Waxdal M, Kagan J. Assessment of the effects of instrumentation, monoclonal antibody, and fluorochrome on flow cytometric immunophenotyping: a report based on 2 years of the NIAID DAIDS flow cytometry quality assessment program. Clinical Immunology and Immunopathology. 66: 150-62. PMID 7680972 DOI: 10.1006/Clin.1993.1019  0.01
1991 Kagan J, Snidman N, Julia-Sellers M, Johnson MO. Temperament and allergic symptoms. Psychosomatic Medicine. 53: 332-40. PMID 1882014 DOI: 10.1097/00006842-199105000-00007  0.01
1990 Bell IR, Jasnoski ML, Kagan J, King DS. Is allergic rhinitis more frequent in young adults with extreme shyness? A preliminary survey. Psychosomatic Medicine. 52: 517-25. PMID 2247557 DOI: 10.1097/00006842-199009000-00004  0.01
1987 Moody DJ, Kagan J, Liao D, Ellison GW, Myers LW. Administration of monthly-pulse cyclophosphamide in multiple sclerosis patients. Effects of long-term treatment on immunologic parameters. Journal of Neuroimmunology. 14: 161-73. PMID 3818941 DOI: 10.1016/0165-5728(87)90050-6  0.01
1981 Ben-Sasson SZ, Kagan J. Antigen-induced proliferation of murine T-lymphocytes in vitro. II. The effect of different macrophage populations on the antigen-induced proliferative response. Journal of Immunological Methods. 41: 321-31. PMID 6971903 DOI: 10.1016/0022-1759(81)90194-0  0.01
1980 Kagan J, Ben-Sasson SZ. Antigen-induced proliferation of murine T-lymphocytes in vitro. I. Characterization of the lymphocyte culture system. Journal of Immunological Methods. 37: 15-27. PMID 6968800 DOI: 10.1016/0022-1759(80)90177-5  0.01
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