Jonathan C. Kagan, Ph.D. - Publications

Affiliations: 
2003 Yale University, New Haven, CT 
Area:
Microbiology Biology, Cell Biology, Genetics, Molecular Biology

116 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Evavold CL, Hafner-Bratkovič I, Devant P, D'Andrea JM, Ngwa EM, Boršić E, Doench JG, LaFleur MW, Sharpe AH, Thiagarajah JR, Kagan JC. Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. Cell. PMID 34289345 DOI: 10.1016/j.cell.2021.06.028  0.01
2021 Maiti G, Frikeche J, Lam CY, Biswas A, Shinde V, Samanovic M, Kagan JC, Mulligan MJ, Chakravarti S. Matrix lumican endocytosed by immune cells controls receptor ligand trafficking to promote TLR4 and restrict TLR9 in sepsis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34215697 DOI: 10.1073/pnas.2100999118  0.01
2021 Zhivaki D, Kagan JC. NLRP3 inflammasomes that induce antitumor immunity. Trends in Immunology. PMID 34034975 DOI: 10.1016/j.it.2021.05.001  0.01
2021 Orzalli MH, Prochera A, Payne L, Smith A, Garlick JA, Kagan JC. Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells. Immunity. PMID 33979579 DOI: 10.1016/j.immuni.2021.04.012  1
2021 Ernandes MJ, Kagan JC. Interferon-Independent Restriction of RNA Virus Entry and Replication by a Class of Damage-Associated Molecular Patterns. Mbio. 12. PMID 33849978 DOI: 10.1128/mBio.00584-21  0.01
2021 Gauthier AE, Chandler CE, Poli V, Gardner FM, Tekiau A, Smith R, Bonham KS, Cordes EE, Shank TM, Zanoni I, Goodlett DR, Biller SJ, Ernst RK, Rotjan RD, Kagan JC. Deep-sea microbes as tools to refine the rules of innate immune pattern recognition. Science Immunology. 6. PMID 33712473 DOI: 10.1126/sciimmunol.abe0531  1
2020 Zhivaki D, Borriello F, Chow OA, Doran B, Fleming I, Theisen DJ, Pallis P, Shalek AK, Sokol CL, Zanoni I, Kagan JC. Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity. Cell Reports. 33: 108381. PMID 33207188 DOI: 10.1016/j.celrep.2020.108381  1
2020 Prestes EB, Alves LS, Rodrigues DAS, Dutra FF, Fernandez PL, Paiva CN, Kagan JC, Bozza MT. Mitochondrial Reactive Oxygen Species Participate in Signaling Triggered by Heme in Macrophages and upon Hemolysis. Journal of Immunology (Baltimore, Md. : 1950). PMID 33037139 DOI: 10.4049/jimmunol.1900886  0.01
2020 Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, et al. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science (New York, N.Y.). 369. PMID 32943500 DOI: 10.1126/Science.Aas8995  1
2020 Fitzgerald KA, Kagan JC. Toll-like Receptors and the Control of Immunity. Cell. 180: 1044-1066. PMID 32164908 DOI: 10.1016/J.Cell.2020.02.041  1
2019 Stanifer ML, Mukenhirn M, Muenchau S, Pervolaraki K, Kanaya T, Albrecht D, Odendall C, Hielscher T, Haucke V, Kagan JC, Bartfeld S, Ohno H, Boulant S. Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells. Nature Microbiology. PMID 31686029 DOI: 10.1038/S41564-019-0594-3  1
2019 Wyman Engen N, Huppler Hullsiek K, Belloso WH, Finley E, Hudson F, Denning E, Carey C, Pearson M, Kagan J. A randomized evaluation of on-site monitoring nested in a multinational randomized trial. Clinical Trials (London, England). 1740774519881616. PMID 31647325 DOI: 10.1177/1740774519881616  0.01
2019 Lieberman J, Wu H, Kagan JC. Gasdermin D activity in inflammation and host defense. Science Immunology. 4. PMID 31492708 DOI: 10.1126/Sciimmunol.Aav1447  1
2019 Evavold CL, Kagan JC. Inflammasomes: Threat-Assessment Organelles of the Innate Immune System. Immunity. PMID 31473100 DOI: 10.1016/J.Immuni.2019.08.005  0.01
2019 Rotjan RD, Sharp KH, Gauthier AE, Yelton R, Lopez EMB, Carilli J, Kagan JC, Urban-Rich J. Patterns, dynamics and consequences of microplastic ingestion by the temperate coral, Astrangia poculata. Proceedings. Biological Sciences. 286: 20190726. PMID 31238843 DOI: 10.1098/Rspb.2019.0726  1
2019 Barnett KC, Kagan JC. Lipids that directly regulate innate immune signal transduction. Innate Immunity. 1753425919852695. PMID 31180799 DOI: 10.1177/1753425919852695  0.01
2019 Odendall C, Kagan JC. Host-Encoded Sensors of Bacteria: Our Windows into the Microbial World. Microbiology Spectrum. 7. PMID 31152521 DOI: 10.1128/Microbiolspec.Bai-0011-2019  1
2019 de Oliveira Mann CC, Orzalli MH, King DS, Kagan JC, Lee ASY, Kranzusch PJ. Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation. Cell Reports. 27: 1165-1175.e5. PMID 31018131 DOI: 10.1016/J.Celrep.2019.03.098  1
2019 Tan Y, Kagan JC. Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility. Cell. PMID 30853218 DOI: 10.1016/J.Cell.2019.01.039  1
2019 Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ, Kagan JC. Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. Cell. PMID 30827685 DOI: 10.1016/J.Cell.2019.01.049  0.01
2019 Evavold CL, Kagan JC. Defying Death: The (W)hole Truth about the Fate of GSDMD Pores. Immunity. 50: 15-17. PMID 30650374 DOI: 10.1016/J.Immuni.2018.12.032  0.01
2018 Chow J, Kagan JC. The Fly Way of Antiviral Resistance and Disease Tolerance. Advances in Immunology. 140: 59-93. PMID 30366519 DOI: 10.1016/Bs.Ai.2018.08.002  1
2018 Shaw DK, Tate AT, Schneider DS, Levashina EA, Kagan JC, Pal U, Fikrig E, Pedra JHF. Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance. Trends in Immunology. PMID 30301592 DOI: 10.1016/J.It.2018.09.003  0.01
2018 Orzalli MH, Smith A, Jurado KA, Iwasaki A, Garlick JA, Kagan JC. An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication. Molecular Cell. PMID 30100266 DOI: 10.1016/J.Molcel.2018.07.009  1
2018 Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling. Cell Host & Microbe. 23: 571. PMID 29649448 DOI: 10.1016/j.chom.2018.03.005  1
2018 Franz KM, Neidermyer WJ, Tan YJ, Whelan SPJ, Kagan JC. STING-dependent translation inhibition restricts RNA virus replication. Proceedings of the National Academy of Sciences of the United States of America. PMID 29440426 DOI: 10.1073/Pnas.1716937115  1
2018 Tan Y, Kagan JC. Biochemical Isolation of the Myddosome from Murine Macrophages. Methods in Molecular Biology (Clifton, N.J.). 1714: 79-95. PMID 29177857 DOI: 10.1007/978-1-4939-7519-8_6  1
2017 Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Immunity. PMID 29195811 DOI: 10.1016/J.Immuni.2017.11.013  1
2017 Zanoni I, Tan Y, Di Gioia M, Springstead JR, Kagan JC. By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation. Immunity. 47: 697-709.e3. PMID 29045901 DOI: 10.1016/J.Immuni.2017.09.010  1
2017 Evavold C, Kagan JC. How inflammasomes inform adaptive immunity. Journal of Molecular Biology. PMID 28987733 DOI: 10.1016/J.Jmb.2017.09.019  0.01
2017 Odendall C, Voak AA, Kagan JC. Type III IFNs Are Commonly Induced by Bacteria-Sensing TLRs and Reinforce Epithelial Barriers during Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 28954888 DOI: 10.4049/Jimmunol.1700250  1
2017 Chow J, Márka Z, Bartos I, Márka S, Kagan JC. Environmental Stress Causes Lethal Neuro-Trauma during Asymptomatic Viral Infections. Cell Host & Microbe. 22: 48-60.e5. PMID 28704652 DOI: 10.1016/J.Chom.2017.06.010  1
2017 Orzalli MH, Kagan JC. Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection. Trends in Cell Biology. PMID 28642032 DOI: 10.1016/J.Tcb.2017.05.007  1
2017 Franz KM, Kagan JC. Innate Immune Receptors as Competitive Determinants of Cell Fate. Molecular Cell. 66: 750-760. PMID 28622520 DOI: 10.1016/J.Molcel.2017.05.009  1
2017 Kagan JC. Lipopolysaccharide Detection across the Kingdoms of Life. Trends in Immunology. PMID 28551077 DOI: 10.1016/J.It.2017.05.001  0.01
2017 Kieser KJ, Kagan JC. Multi-receptor detection of individual bacterial products by the innate immune system. Nature Reviews. Immunology. PMID 28461704 DOI: 10.1038/Nri.2017.25  0.01
2017 Odendall C, Kagan JC. Activation and pathogenic manipulation of the sensors of the innate immune system. Microbes and Infection. PMID 28093320 DOI: 10.1016/J.Micinf.2017.01.003  1
2017 Rosadini C, Kagan J. P-321 Regulation of Innate Immunity in Intestinal Epithelial Cells Inflammatory Bowel Diseases. 23. DOI: 10.1097/01.Mib.0000512862.50021.C1  0.01
2016 Orzalli MH, Kagan JC. A one-protein signaling pathway in the innate immune system. Science Immunology. 1: eaah6184. PMID 28783697 DOI: 10.1126/Sciimmunol.Aah6184  1
2016 Rosadini CV, Kagan JC. Early innate immune responses to bacterial LPS. Current Opinion in Immunology. 44: 14-19. PMID 27842237 DOI: 10.1016/J.Coi.2016.10.005  1
2016 Tan Y, Kagan JC. Microbe-inducible trafficking pathways that control Toll-like Receptor signaling. Traffic (Copenhagen, Denmark). PMID 27731905 DOI: 10.1111/Tra.12454  1
2016 Guerrant RL, Leite AM, Pinkerton R, Medeiros PH, Cavalcante PA, DeBoer M, Kosek M, Duggan C, Gewirtz A, Kagan JC, Gauthier AE, Swann J, Mayneris-Perxachs J, Bolick DT, Maier EA, et al. Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil. Plos One. 11: e0158772. PMID 27690129 DOI: 10.1371/Journal.Pone.0158772  1
2016 Kagan JC. Editorial overview: Emerging concepts in host-virus interactions. Current Opinion in Microbiology. PMID 27426076 DOI: 10.1016/J.Mib.2016.06.006  0.01
2016 Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, ... ... Kagan JC, et al. Control of the innate immune response by the mevalonate pathway. Nature Immunology. PMID 27270400 DOI: 10.1038/Ni.3487  1
2016 Kagan J, Giang DD, Iademarco MF, Phung VT, Lau CY, Quang NN. Assessing Clinical Research Capacity in Vietnam: A Framework for Strengthening Capability for Clinical Trials in Developing Countries. Public Health Reports (Washington, D.C. : 1974). 131: 396-403. PMID 27252559 DOI: 10.1177/003335491613100305  1
2016 Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado CA, Shao F, Wu H, Springstead JR, Kagan JC. An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science (New York, N.Y.). PMID 27103670 DOI: 10.1126/Science.Aaf3036  1
2016 Ferreira AR, Magalhães AC, Camões F, Gouveia A, Vieira M, Kagan JC, Ribeiro D. Hepatitis C virus NS3-4A inhibits the peroxisomal MAVS-dependent antiviral signalling response. Journal of Cellular and Molecular Medicine. PMID 26865163 DOI: 10.1111/Jcmm.12801  1
2015 Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Philip NH, Brodsky IE, Mecsas J, Kagan JC. A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4. Cell Host & Microbe. 18: 682-93. PMID 26651944 DOI: 10.1016/J.Chom.2015.11.006  1
2015 Tan Y, Zanoni I, Cullen TW, Goodman AL, Kagan JC. Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria. Immunity. PMID 26546281 DOI: 10.1016/J.Immuni.2015.10.008  1
2015 Rajaiah R, Perkins DJ, Ireland DD, Vogel SN. CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance. Proceedings of the National Academy of Sciences of the United States of America. 112: 8391-6. PMID 26106158 DOI: 10.1073/Pnas.1424980112  1
2015 Chow J, Franz KM, Kagan JC. PRRs are watching you: Localization of innate sensing and signaling regulators. Virology. 479: 104-9. PMID 25800355 DOI: 10.1016/J.Virol.2015.02.051  1
2015 Odendall C, Kagan JC. The unique regulation and functions of type III interferons in antiviral immunity. Current Opinion in Virology. 12: 47-52. PMID 25771505 DOI: 10.1016/J.Coviro.2015.02.003  1
2015 Rosadini CV, Kagan JC. Microbial strategies for antagonizing Toll-like-receptor signal transduction. Current Opinion in Immunology. 32: 61-70. PMID 25615700 DOI: 10.1016/J.Coi.2014.12.011  1
2015 Brubaker SW, Bonham KS, Zanoni I, Kagan JC. Innate immune pattern recognition: a cell biological perspective. Annual Review of Immunology. 33: 257-90. PMID 25581309 DOI: 10.1146/Annurev-Immunol-032414-112240  1
2015 Kagan JC, Barton GM. Emerging principles governing signal transduction by pattern-recognition receptors. Cold Spring Harbor Perspectives in Biology. 7: a016253. PMID 25395297 DOI: 10.1101/Cshperspect.A016253  1
2014 Kagan JC, Magupalli VG, Wu H. SMOCs: supramolecular organizing centres that control innate immunity. Nature Reviews. Immunology. 14: 821-6. PMID 25359439 DOI: 10.1038/Nri3757  1
2014 Kagan JC. Common mechanisms activate plant guard receptors and TLR4. Trends in Immunology. 35: 454-6. PMID 25224694 DOI: 10.1016/J.It.2014.08.009  1
2014 Teigler JE, Kagan JC, Barouch DH. Late endosomal trafficking of alternative serotype adenovirus vaccine vectors augments antiviral innate immunity. Journal of Virology. 88: 10354-63. PMID 24991003 DOI: 10.1128/Jvi.00936-14  1
2014 Gwadz M, Cleland CM, Belkin M, Ritchie A, Leonard N, Riedel M, Banfield A, Colon P, Elharrar V, Kagan J, Mildvan D. ACT2 peer-driven intervention increases enrollment into HIV/AIDS medical studies among African Americans/Blacks and Hispanics: A cluster randomized controlled trial. Aids and Behavior. 18: 2409-22. PMID 24961193 DOI: 10.1007/S10461-014-0829-5  1
2014 Odendall C, Dixit E, Stavru F, Bierne H, Franz KM, Durbin AF, Boulant S, Gehrke L, Cossart P, Kagan JC. Diverse intracellular pathogens activate type III interferon expression from peroxisomes. Nature Immunology. 15: 717-26. PMID 24952503 DOI: 10.1038/Ni.2915  1
2014 Bonham KS, Kagan JC. Endosomes as platforms for NOD-like receptor signaling. Cell Host & Microbe. 15: 523-5. PMID 24832447 DOI: 10.1016/J.Chom.2014.05.001  1
2014 Tan Y, Kagan JC. A cross-disciplinary perspective on the innate immune responses to bacterial lipopolysaccharide. Molecular Cell. 54: 212-23. PMID 24766885 DOI: 10.1016/J.Molcel.2014.03.012  1
2014 Brubaker SW, Gauthier AE, Mills EW, Ingolia NT, Kagan JC. A bicistronic MAVS transcript highlights a class of truncated variants in antiviral immunity. Cell. 156: 800-11. PMID 24529381 DOI: 10.1016/J.Cell.2014.01.021  1
2014 Bonham KS, Orzalli MH, Hayashi K, Wolf AI, Glanemann C, Weninger W, Iwasaki A, Knipe DM, Kagan JC. A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction. Cell. 156: 705-16. PMID 24529375 DOI: 10.1016/J.Cell.2014.01.019  1
2014 Franz KM, Kagan JC. Finding a needle in a haystack of needles - a productive hunt for interferon stimulated genes with antiviral activity. Immunology and Cell Biology. 92: 205-7. PMID 24418815 DOI: 10.1038/Icb.2013.108  1
2014 Al-Shahi Salman R, Beller E, Kagan J, Hemminki E, Phillips RS, Savulescu J, Macleod M, Wisely J, Chalmers I. Increasing value and reducing waste in biomedical research regulation and management. Lancet. 383: 176-85. PMID 24411646 DOI: 10.1016/S0140-6736(13)62297-7  1
2013 Kagan JC. Immunology. Sensing endotoxins from within. Science (New York, N.Y.). 341: 1184-5. PMID 24031006 DOI: 10.1126/Science.1243939  1
2013 Kagan JC. Recognition for an innate explorer. Cell. 154: 261-4. PMID 23870114 DOI: 10.1016/J.Cell.2013.06.047  1
2013 Kagan JC, Horng T. NLRP3 inflammasome activation: CD36 serves double duty. Nature Immunology. 14: 772-4. PMID 23867926 DOI: 10.1038/Ni.2668  1
2013 Odendall C, Kagan JC. Peroxisomes and the antiviral responses of mammalian cells. Sub-Cellular Biochemistry. 69: 67-75. PMID 23821143 DOI: 10.1007/978-94-007-6889-5_4  1
2013 Cho JA, Lee AH, Platzer B, Cross BC, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host & Microbe. 13: 558-69. PMID 23684307 DOI: 10.1016/J.Chom.2013.03.011  1
2013 Dixit E, Kagan JC. Intracellular pathogen detection by RIG-I-like receptors. Advances in Immunology. 117: 99-125. PMID 23611287 DOI: 10.1016/B978-0-12-410524-9.00004-9  1
2012 Kagan JC. Signaling organelles of the innate immune system. Cell. 151: 1168-78. PMID 23217704 DOI: 10.1016/J.Cell.2012.11.011  1
2012 Velupillai P, Sung CK, Andrews E, Moran J, Beier D, Kagan J, Benjamin T. Polymorphisms in toll-like receptor 4 underlie susceptibility to tumor induction by the mouse polyomavirus. Journal of Virology. 86: 11541-7. PMID 22896604 DOI: 10.1128/Jvi.01614-12  1
2012 Kagan JC. Defining the subcellular sites of innate immune signal transduction. Trends in Immunology. 33: 442-8. PMID 22817912 DOI: 10.1016/J.It.2012.06.005  1
2012 Kagan JC, Iwasaki A. Phagosome as the organelle linking innate and adaptive immunity. Traffic (Copenhagen, Denmark). 13: 1053-61. PMID 22577865 DOI: 10.1111/J.1600-0854.2012.01377.X  1
2012 Marek LR, Kagan JC. Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila. Immunity. 36: 612-22. PMID 22464168 DOI: 10.1016/J.Immuni.2012.01.019  1
2012 Edison N, Zuri D, Maniv I, Bornstein B, Lev T, Gottfried Y, Kemeny S, Garcia-Fernandez M, Kagan J, Larisch S. The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo. Cell Death and Differentiation. 19: 356-68. PMID 21869827 DOI: 10.1038/Cdd.2011.112  1
2011 Zanoni I, Ostuni R, Marek LR, Barresi S, Barbalat R, Barton GM, Granucci F, Kagan JC. CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell. 147: 868-80. PMID 22078883 DOI: 10.1016/J.Cell.2011.09.051  1
2011 Wang S, Villablanca EJ, De Calisto J, Gomes DC, Nguyen DD, Mizoguchi E, Kagan JC, Reinecker HC, Hacohen N, Nagler C, Xavier RJ, Rossi-Bergmann B, Chen YB, Blomhoff R, Snapper SB, et al. MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. Journal of Immunology (Baltimore, Md. : 1950). 187: 141-50. PMID 21646294 DOI: 10.4049/Jimmunol.1003740  1
2011 Marek LR, Kagan JC. Deciphering the function of nucleic acid sensing TLRs one regulatory step at a time. Frontiers in Bioscience (Landmark Edition). 16: 2060-8. PMID 21622162 DOI: 10.2741/3839  1
2011 Wang L, Trebicka E, Fu Y, Waggoner L, Akira S, Fitzgerald KA, Kagan JC, Cherayil BJ. Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM. Journal of Innate Immunity. 3: 437-46. PMID 21494017 DOI: 10.1159/000324833  1
2011 Liao AP, Salajegheh M, Nazareno R, Kagan JC, Jubin RG, Greenberg SA. Interferon β is associated with type 1 interferon-inducible gene expression in dermatomyositis. Annals of the Rheumatic Diseases. 70: 831-6. PMID 21177291 DOI: 10.1136/ard.2010.139949  1
2010 Kagan JC. Recycling endosomes and TLR signaling--the Rab11 GTPase leads the way. Immunity. 33: 578-80. PMID 21029967 DOI: 10.1016/J.Immuni.2010.10.003  1
2010 Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC. Peroxisomes are signaling platforms for antiviral innate immunity. Cell. 141: 668-81. PMID 20451243 DOI: 10.1016/J.Cell.2010.04.018  1
2010 Kagan JC. "Complementing" toll signaling. Science Signaling. 3: pe15. PMID 20442416 DOI: 10.1126/Scisignal.3120Pe15  1
2009 Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ. Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. The Journal of Clinical Investigation. 119: 3322-8. PMID 19809161 DOI: 10.1172/Jci39939  1
2009 Barton GM, Kagan JC. A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nature Reviews. Immunology. 9: 535-42. PMID 19556980 DOI: 10.1038/Nri2587  1
2008 Kagan JC, Su T, Horng T, Chow A, Akira S, Medzhitov R. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nature Immunology. 9: 361-8. PMID 18297073 DOI: 10.1038/Ni1569  1
2006 Kagan JC, Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell. 125: 943-55. PMID 16751103 DOI: 10.1016/J.Cell.2006.03.047  1
2006 Barton GM, Kagan JC, Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nature Immunology. 7: 49-56. PMID 16341217 DOI: 10.1038/Ni1280  1
2005 Kagan JC, Murata T, Roy CR. Analysis of Rab1 recruitment to vacuoles containing Legionella pneumophila. Methods in Enzymology. 403: 71-81. PMID 16473578 DOI: 10.1016/S0076-6879(05)03007-7  1
2005 Lambert JS, Moye J, Plaeger SF, Stiehm ER, Bethel J, Mofenson LM, Mathieson B, Kagan J, Rosenblatt H, Paxton H, Suter H, Landay A. Association of selected phenotypic markers of lymphocyte activation and differentiation with perinatal human immunodeficiency virus transmission and infant infection. Clinical and Diagnostic Laboratory Immunology. 12: 622-31. PMID 15879023 DOI: 10.1128/Cdli.12.5.622-631.2005  1
2005 Mildvan D, Spritzler J, Grossberg SE, Fahey JL, Johnston DM, Schock BR, Kagan J. Serum neopterin, an immune activation marker, independently predicts disease progression in advanced HIV-1 infection. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 40: 853-8. PMID 15736019 DOI: 10.1086/427877  1
2005 Nagai H, Cambronne ED, Kagan JC, Amor JC, Kahn RA, Roy CR. A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 826-31. PMID 15613486 DOI: 10.1073/Pnas.0406239101  1
2004 Mildvan D, Bosch RJ, Kim RS, Spritzler J, Haas DW, Kuritzkes D, Kagan J, Nokta M, DeGruttola V, Moreno M, Landay A. Immunophenotypic markers and antiretroviral therapy (IMART): T cell activation and maturation help predict treatment response. The Journal of Infectious Diseases. 189: 1811-20. PMID 15122517 DOI: 10.1086/383277  1
2004 Kagan JC, Stein MP, Pypaert M, Roy CR. Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle. The Journal of Experimental Medicine. 199: 1201-11. PMID 15117975 DOI: 10.1084/Jem.20031706  1
2004 Guignot J, Caron E, Beuzón C, Bucci C, Kagan J, Roy C, Holden DW. Microtubule motors control membrane dynamics of Salmonella-containing vacuoles. Journal of Cell Science. 117: 1033-45. PMID 14970261 DOI: 10.1242/Jcs.00949  0.01
2003 Spritzler J, Mildvan D, Russo A, Asthana D, Livnat D, Schock B, Kagan J, Landay A, Haas DW. Can immune markers predict subsequent discordance between immunologic and virologic responses to antiretroviral therapy? Adult AIDS Clinical Trials Group. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 37: 551-8. PMID 12905140 DOI: 10.1086/376986  1
2002 Kagan JC, Roy CR. Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites. Nature Cell Biology. 4: 945-54. PMID 12447391 DOI: 10.1038/Ncb883  1
2002 Nagai H, Kagan JC, Zhu X, Kahn RA, Roy CR. A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes. Science (New York, N.Y.). 295: 679-82. PMID 11809974 DOI: 10.1126/Science.1067025  1
2000 Coers J, Kagan JC, Matthews M, Nagai H, Zuckman DM, Roy CR. Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth. Molecular Microbiology. 38: 719-36. PMID 11115108 DOI: 10.1046/J.1365-2958.2000.02176.X  1
2000 Reimann KA, O'Gorman MRG, Spritzler J, Wilkening CL, Sabath DE, Helm K, Campbell DE, O'Gorman M, Bessent E, Plaeger S, Donnenberg A, Douglas S, Mandy F, Nicholson J, Reimann K, ... ... Kagan J, et al. Multisite comparison of CD4 and CD8 T-lymphocyte counting by single- versus multiple-platform methodologies Clinical and Vaccine Immunology. 7: 344-351. PMID 10799444 DOI: 10.1128/Cdli.7.3.344-351.2000  1
1997 Mildvan D, Landay A, De Gruttola V, Machado SG, Kagan J. An approach to the validation of markers for use in AIDS clinical trials. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 24: 764-74. PMID 9142767 DOI: 10.1093/Clinids/24.5.764  1
1997 Lieberman J, Skolnik PR, Parkerson GR, Fabry JA, Landry B, Bethel J, Kagan J. Safety of Autologous, Ex Vivo-Expanded Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Infusion in HIV-Infected Patients Blood. 90: 2196-2206. DOI: 10.1182/Blood.V90.6.2196  0.01
1996 Nicholson J, Kidd P, Mandy F, Livnat D, Kagan J. Three-color supplement to the NIAID DAIDS guideline for flow cytometric immunophenotyping. Cytometry. 26: 227-30. PMID 8889396 DOI: 10.1002/(Sici)1097-0320(19960915)26:3<227::Aid-Cyto8>3.0.Co;2-B  1
1996 Valentine FT, Kundu S, Haslett PA, Katzenstein D, Beckett L, Spino C, Borucki M, Vasquez M, Smith G, Korvick J, Kagan J, Merigan TC. A randomized, placebo-controlled study of the immunogenicity of human immunodeficiency virus (HIV) rgp160 vaccine in HIV-infected subjects with > or = 400/mm3 CD4 T lymphocytes (AIDS Clinical Trials Group Protocol 137). The Journal of Infectious Diseases. 173: 1336-46. PMID 8648205 DOI: 10.1093/Infdis/173.6.1336  1
1995 Connelly MC, Knight M, Giorgi JV, Kagan J, Landay AL, Parker JW, Page E, Spino C, Wilkening C, Mercolino TJ. Standardization of absolute CD4+ lymphocyte counts across laboratories: an evaluation of the Ortho CytoronAbsolute flow cytometry system on normal donors. Cytometry. 22: 200-10. PMID 8556951 DOI: 10.1002/Cyto.990220307  1
1993 Kagan J, Gelman R, Waxdal M, Kidd P. NIAID Division of AIDS flow cytometry quality assessment program. Annals of the New York Academy of Sciences. 677: 50-2. PMID 8494245 DOI: 10.1111/J.1749-6632.1993.Tb38763.X  1
1993 Calvelli T, Denny TN, Paxton H, Gelman R, Kagan J. Guideline for flow cytometric immunophenotyping: a report from the National Institute of Allergy and Infectious Diseases, Division of AIDS. Cytometry. 14: 702-15. PMID 8243200 DOI: 10.1002/Cyto.990140703  1
1993 Gelman R, Cheng SC, Kidd P, Waxdal M, Kagan J. Assessment of the effects of instrumentation, monoclonal antibody, and fluorochrome on flow cytometric immunophenotyping: a report based on 2 years of the NIAID DAIDS flow cytometry quality assessment program. Clinical Immunology and Immunopathology. 66: 150-62. PMID 7680972 DOI: 10.1006/Clin.1993.1019  1
1991 Kagan J, Snidman N, Julia-Sellers M, Johnson MO. Temperament and allergic symptoms. Psychosomatic Medicine. 53: 332-40. PMID 1882014 DOI: 10.1097/00006842-199105000-00007  0.01
1990 Bell IR, Jasnoski ML, Kagan J, King DS. Is allergic rhinitis more frequent in young adults with extreme shyness? A preliminary survey. Psychosomatic Medicine. 52: 517-25. PMID 2247557 DOI: 10.1097/00006842-199009000-00004  0.01
1987 Moody DJ, Kagan J, Liao D, Ellison GW, Myers LW. Administration of monthly-pulse cyclophosphamide in multiple sclerosis patients. Effects of long-term treatment on immunologic parameters. Journal of Neuroimmunology. 14: 161-73. PMID 3818941 DOI: 10.1016/0165-5728(87)90050-6  0.01
1981 Ben-Sasson SZ, Kagan J. Antigen-induced proliferation of murine T-lymphocytes in vitro. II. The effect of different macrophage populations on the antigen-induced proliferative response. Journal of Immunological Methods. 41: 321-31. PMID 6971903 DOI: 10.1016/0022-1759(81)90194-0  1
1980 Kagan J, Ben-Sasson SZ. Antigen-induced proliferation of murine T-lymphocytes in vitro. I. Characterization of the lymphocyte culture system. Journal of Immunological Methods. 37: 15-27. PMID 6968800 DOI: 10.1016/0022-1759(80)90177-5  1
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