Martijn Fenaux, Ph.D. - Publications

Affiliations: 
2004 Virginia Polytechnic and State University, United States 
Area:
Veterinary Science Biology, Molecular Biology

30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Romero FA, Jones C, Xu Y, Fenaux M, Halcomb RL. The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. Journal of Medicinal Chemistry. PMID 31930920 DOI: 10.1021/acs.jmedchem.9b01701  0.4
2018 Feng JY, Wang T, Park Y, Babusis D, Birkus G, Xu Y, Voitenleitner C, Fenaux M, Yang H, Eng S, Tirunagari N, Kirschberg T, Cho A, Ray AS. Non-proteinogenic Amino Acid Containing Nucleotide Prodrug to Improve Oral Delivery of a Hepatitis C Virus Treatment. Antimicrobial Agents and Chemotherapy. PMID 29866875 DOI: 10.1128/AAC.00620-18  0.4
2015 Kirschberg TA, Mish MR, Zhang L, Squires NH, Wang KY, Cho A, Feng JY, Fenaux M, Babusis D, Park Y, Ray AS, Kim CU. Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors. Bioorganic & Medicinal Chemistry Letters. 25: 1040-3. PMID 25650256 DOI: 10.1016/j.bmcl.2015.01.021  0.84
2014 Mish MR, Cho A, Kirschberg T, Xu J, Zonte CS, Fenaux M, Park Y, Babusis D, Feng JY, Ray AS, Kim CU. Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 3092-5. PMID 24907145 DOI: 10.1016/j.bmcl.2014.05.015  0.84
2014 Feng JY, Cheng G, Perry J, Barauskas O, Xu Y, Fenaux M, Eng S, Tirunagari N, Peng B, Yu M, Tian Y, Lee YJ, Stepan G, Lagpacan LL, Jin D, et al. Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug. Antimicrobial Agents and Chemotherapy. 58: 1930-42. PMID 24419349 DOI: 10.1128/AAC.02351-13  0.84
2014 Boyce SE, Tirunagari N, Niedziela-Majka A, Perry J, Wong M, Kan E, Lagpacan L, Barauskas O, Hung M, Fenaux M, Appleby T, Watkins WJ, Schmitz U, Sakowicz R. Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors. Plos One. 9: e84808. PMID 24416288 DOI: 10.1371/journal.pone.0084808  0.84
2014 Lazerwith SE, Lew W, Zhang J, Morganelli P, Liu Q, Canales E, Clarke MO, Doerffler E, Byun D, Mertzman M, Ye H, Chong L, Xu L, Appleby T, Chen X, ... Fenaux M, et al. Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection. Journal of Medicinal Chemistry. 57: 1893-901. PMID 24144213 DOI: 10.1021/jm401420j  0.84
2014 Cho A, Zhang L, Xu J, Lee R, Butler T, Metobo S, Aktoudianakis V, Lew W, Ye H, Clarke M, Doerffler E, Byun D, Wang T, Babusis D, Carey AC, ... ... Fenaux M, et al. Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients. Journal of Medicinal Chemistry. 57: 1812-25. PMID 23547794 DOI: 10.1021/jm400201a  0.84
2013 Fenaux M, Eng S, Leavitt SA, Lee YJ, Mabery EM, Tian Y, Byun D, Canales E, Clarke MO, Doerffler E, Lazerwith SE, Lew W, Liu Q, Mertzman M, Morganelli P, et al. Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase. Antimicrobial Agents and Chemotherapy. 57: 804-10. PMID 23183437 DOI: 10.1128/AAC.02052-12  0.84
2012 Canales E, Carlson JS, Appleby T, Fenaux M, Lee J, Tian Y, Tirunagari N, Wong M, Watkins WJ. Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 4288-92. PMID 22664130 DOI: 10.1016/j.bmcl.2012.05.025  0.84
2011 Shih IH, Vliegen I, Peng B, Yang H, Hebner C, Paeshuyse J, Pürstinger G, Fenaux M, Tian Y, Mabery E, Qi X, Bahador G, Paulson M, Lehman LS, Bondy S, et al. Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase. Antimicrobial Agents and Chemotherapy. 55: 4196-203. PMID 21746939 DOI: 10.1128/AAC.00307-11  0.84
2011 Pokrovskii MV, Bush CO, Beran RK, Robinson MF, Cheng G, Tirunagari N, Fenaux M, Greenstein AE, Zhong W, Delaney WE, Paulson MS. Novel mutations in a tissue culture-adapted hepatitis C virus strain improve infectious-virus stability and markedly enhance infection kinetics. Journal of Virology. 85: 3978-85. PMID 21289124 DOI: 10.1128/JVI.01760-10  0.84
2008 Feng N, Kim B, Fenaux M, Nguyen H, Vo P, Omary MB, Greenberg HB. Role of interferon in homologous and heterologous rotavirus infection in the intestines and extraintestinal organs of suckling mice. Journal of Virology. 82: 7578-90. PMID 18495762 DOI: 10.1128/JVI.00391-08  0.84
2006 Ray P, Fenaux M, Sharma S, Malik J, Subodh S, Bhatnagar S, Greenberg H, Glass RI, Gentsch J, Bhan MK. Quantitative evaluation of rotaviral antigenemia in children with acute rotaviral diarrhea. The Journal of Infectious Diseases. 194: 588-93. PMID 16897656 DOI: 10.1086/505878  0.84
2006 Blutt SE, Fenaux M, Warfield KL, Greenberg HB, Conner ME. Active viremia in rotavirus-infected mice. Journal of Virology. 80: 6702-5. PMID 16775359 DOI: 10.1128/JVI.00329-06  0.84
2006 Fenaux M, Cuadras MA, Feng N, Jaimes M, Greenberg HB. Extraintestinal spread and replication of a homologous EC rotavirus strain and a heterologous rhesus rotavirus in BALB/c mice Journal of Virology. 80: 5219-5232. PMID 16699002 DOI: 10.1128/JVI.02664-05  0.84
2006 Opriessnig T, Fenaux M, Thomas P, Hoogland MJ, Rothschild MF, Meng XJ, Halbur PG. Evidence of breed-dependent differences in susceptibility to porcine circovirus type-2-associated disease and lesions. Veterinary Pathology. 43: 281-93. PMID 16672575 DOI: 10.1354/vp.43-3-281  0.84
2006 Opriessnig T, Halbur PG, Yu S, Thacker EL, Fenaux M, Meng XJ. Effects of the timing of the administration of Mycoplasma hyopneumoniae bacterin on the development of lesions associated with porcine circovirus type 2. The Veterinary Record. 158: 149-54. PMID 16461621  0.84
2005 McKeown NE, Opriessnig T, Thomas P, Guenette DK, Elvinger F, Fenaux M, Halbur PG, Meng XJ. Effects of porcine circovirus type 2 (PCV2) maternal antibodies on experimental infection of piglets with PCV2. Clinical and Diagnostic Laboratory Immunology. 12: 1347-51. PMID 16275955 DOI: 10.1128/CDLI.12.11.1347-1351.2005  0.84
2004 Fenaux M, Opriessnig T, Halbur PG, Elvinger F, Meng XJ. Two amino acid mutations in the capsid protein of type 2 porcine circovirus (PCV2) enhanced PCV2 replication in vitro and attenuated the virus in vivo. Journal of Virology. 78: 13440-6. PMID 15564454 DOI: 10.1128/JVI.78.24.13440-13446.2004  0.84
2004 Opriessnig T, Thacker EL, Yu S, Fenaux M, Meng XJ, Halbur PG. Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2. Veterinary Pathology. 41: 624-40. PMID 15557072 DOI: 10.1354/vp.41-6-624  0.84
2004 McKeown NE, Fenaux M, Halbur PG, Meng XJ. Molecular characterization of porcine TT virus, an orphan virus, in pigs from six different countries. Veterinary Microbiology. 104: 113-7. PMID 15530745 DOI: 10.1016/j.vetmic.2004.08.013  0.84
2004 Fenaux M, Opriessnig T, Halbur PG, Xu Y, Potts B, Meng XJ. Detection and in vitro and in vivo characterization of porcine circovirus DNA from a porcine-derived commercial pepsin product. The Journal of General Virology. 85: 3377-82. PMID 15483254 DOI: 10.1099/vir.0.80429-0  0.84
2004 Fenaux M, Opriessnig T, Halbur PG, Elvinger F, Meng XJ. A chimeric porcine circovirus (PCV) with the immunogenic capsid gene of the pathogenic PCV type 2 (PCV2) cloned into the genomic backbone of the nonpathogenic PCV1 induces protective immunity against PCV2 infection in pigs. Journal of Virology. 78: 6297-303. PMID 15163723 DOI: 10.1128/JVI.78.12.6297-6303.2004  0.84
2004 Opriessnig T, Fenaux M, Yu S, Evans RB, Cavanaugh D, Gallup JM, Pallares FJ, Thacker EL, Lager KM, Meng XJ, Halbur PG. Effect of porcine parvovirus vaccination on the development of PMWS in segregated early weaned pigs coinfected with type 2 porcine circovirus and porcine parvovirus. Veterinary Microbiology. 98: 209-20. PMID 15036529 DOI: 10.1016/j.vetmic.2003.11.006  0.84
2003 Fenaux M, Opriessnig T, Halbur PG, Meng XJ. Immunogenicity and pathogenicity of chimeric infectious DNA clones of pathogenic porcine circovirus type 2 (PCV2) and nonpathogenic PCV1 in weanling pigs. Journal of Virology. 77: 11232-43. PMID 14512571 DOI: 10.1128/JVI.77.20.11232-11243.2003  0.84
2003 Opriessnig T, Yu S, Gallup JM, Evans RB, Fenaux M, Pallares F, Thacker EL, Brockus CW, Ackermann MR, Thomas P, Meng XJ, Halbur PG. Effect of vaccination with selective bacterins on conventional pigs infected with type 2 porcine circovirus. Veterinary Pathology. 40: 521-9. PMID 12949409 DOI: 10.1354/vp.40-5-521  0.84
2002 Haqshenas G, Huang FF, Fenaux M, Guenette DK, Pierson FW, Larsen CT, Shivaprasad HL, Toth TE, Meng XJ. The putative capsid protein of the newly identified avian hepatitis E virus shares antigenic epitopes with that of swine and human hepatitis E viruses and chicken big liver and spleen disease virus. The Journal of General Virology. 83: 2201-9. PMID 12185274 DOI: 10.1099/0022-1317-83-9-2201  0.84
2002 Fenaux M, Halbur PG, Haqshenas G, Royer R, Thomas P, Nawagitgul P, Gill M, Toth TE, Meng XJ. Cloned genomic DNA of type 2 porcine circovirus is infectious when injected directly into the liver and lymph nodes of pigs: characterization of clinical disease, virus distribution, and pathologic lesions. Journal of Virology. 76: 541-51. PMID 11752145 DOI: 10.1128/JVI.76.2.541-551.2002  0.84
2000 Fenaux M, Halbur PG, Gill M, Toth TE, Meng XJ. Genetic characterization of type 2 porcine circovirus (PCV-2) from pigs with postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential PCR-restriction fragment length polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2. Journal of Clinical Microbiology. 38: 2494-503. PMID 10878032  0.84
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