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George T. Lountos, Ph.D. - Publications

Affiliations: 
2005 Georgia Institute of Technology, Atlanta, GA 
Area:
Biochemistry
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26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Hewitt WM, Lountos GT, Zlotkowski K, Dahlhauser SD, Saunders LB, Needle D, Tropea JE, Zhan C, Wei G, Ma B, Nussinov R, Waugh DS, Schneekloth JS. Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angewandte Chemie (International Ed. in English). PMID 27038327 DOI: 10.1002/anie.201511351  0.76
2015 Zhao BM, Keasey SL, Tropea JE, Lountos GT, Dyas BK, Cherry S, Raran-Kurussi S, Waugh DS, Ulrich RG. Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. Plos One. 10: e0134984. PMID 26302245 DOI: 10.1371/journal.pone.0134984  0.76
2015 Lountos GT, Austin BP, Tropea JE, Waugh DS. Structure of human dual-specificity phosphatase 7, a potential cancer drug target. Acta Crystallographica. Section F, Structural Biology Communications. 71: 650-6. PMID 26057789 DOI: 10.1107/S2053230X1500504X  0.76
2015 Needle D, Lountos GT, Waugh DS. Structures of the Middle East respiratory syndrome coronavirus 3C-like protease reveal insights into substrate specificity. Acta Crystallographica. Section D, Biological Crystallography. 71: 1102-11. PMID 25945576 DOI: 10.1107/S1399004715003521  0.76
2015 Lountos GT, Cherry S, Tropea JE, Waugh DS. Structural analysis of human dual-specificity phosphatase 22 complexed with a phosphotyrosine-like substrate. Acta Crystallographica. Section F, Structural Biology Communications. 71: 199-205. PMID 25664796 DOI: 10.1107/S2053230X15000217  0.76
2013 Hogan M, Bahta M, Cherry S, Lountos GT, Tropea JE, Zhao BM, Burke TR, Waugh DS, Ulrich RG. Biomolecular Interactions of small-molecule inhibitors affecting the YopH protein tyrosine phosphatase. Chemical Biology & Drug Design. 81: 323-33. PMID 23241354 DOI: 10.1111/cbdd.12097  0.76
2012 Lountos GT, Tropea JE, Waugh DS. Structure of the cytoplasmic domain of Yersinia pestis YscD, an essential component of the type III secretion system. Acta Crystallographica. Section D, Biological Crystallography. 68: 201-9. PMID 22349221 DOI: 10.1107/S0907444911054308  0.76
2011 Lountos GT, Jobson AG, Tropea JE, Self CR, Zhang G, Pommier Y, Shoemaker RH, Waugh DS. Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy Journal of Structural Biology. 176: 292-301. PMID 21963792 DOI: 10.1016/j.jsb.2011.09.008  0.76
2011 Lountos GT, Jobson AG, Tropea JE, Self CR, Zhang G, Pommier Y, Shoemaker RH, Waugh DS. X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket Febs Letters. 585: 3245-3249. PMID 21907711 DOI: 10.1016/j.febslet.2011.08.050  0.76
2011 Kim SE, Bahta M, Lountos GT, Ulrich RG, Burke TR, Waugh DS. Isothiazolidinone (IZD) as a phosphoryl mimetic in inhibitors of the Yersinia pestis protein tyrosine phosphatase YopH. Acta Crystallographica. Section D, Biological Crystallography. 67: 639-45. PMID 21697602 DOI: 10.1107/S0907444911018610  0.76
2011 Lountos GT, Tropea JE, Waugh DS. Structure of human dual-specificity phosphatase 27 at 2.38 Å resolution. Acta Crystallographica. Section D, Biological Crystallography. 67: 471-9. PMID 21543850 DOI: 10.1107/S090744491100970X  0.76
2011 Bahta M, Lountos GT, Dyas B, Kim SE, Ulrich RG, Waugh DS, Burke TR. Utilization of nitrophenylphosphates and oxime-based ligation for the development of nanomolar affinity inhibitors of the Yersinia pestis outer protein H (YopH) phosphatase. Journal of Medicinal Chemistry. 54: 2933-43. PMID 21443195 DOI: 10.1021/jm200022g  0.76
2010 Zhang H, Lountos GT, Ching CB, Jiang R. Engineering of glycerol dehydrogenase for improved activity towards 1, 3-butanediol. Applied Microbiology and Biotechnology. 88: 117-24. PMID 20585771 DOI: 10.1007/s00253-010-2735-8  0.76
2010 Muus U, Hose C, Yao W, Kosakowska-Cholody T, Farnsworth D, Dyba M, Lountos GT, Waugh DS, Monks A, Burke TR, Michejda CJ. Development of antiproliferative phenylmaleimides that activate the unfolded protein response. Bioorganic & Medicinal Chemistry. 18: 4535-41. PMID 20472436 DOI: 10.1016/j.bmc.2010.04.057  0.76
2010 Liu F, Hakami RM, Dyas B, Bahta M, Lountos GT, Waugh DS, Ulrich RG, Burke TR. A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH. Bioorganic & Medicinal Chemistry Letters. 20: 2813-6. PMID 20350805 DOI: 10.1016/j.bmcl.2010.03.058  0.76
2009 Lountos GT, Tropea JE, Cherry S, Waugh DS. Overproduction, purification and structure determination of human dual-specificity phosphatase 14. Acta Crystallographica. Section D, Biological Crystallography. 65: 1013-20. PMID 19770498 DOI: 10.1107/S0907444909023762  0.76
2009 Jobson AG, Lountos GT, Lorenzi PL, Llamas J, Connelly J, Cerna D, Tropea JE, Onda A, Zoppoli G, Kondapaka S, Zhang G, Caplen NJ, Cardellina JH, Yoo SS, Monks A, et al. Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]. The Journal of Pharmacology and Experimental Therapeutics. 331: 816-26. PMID 19741151 DOI: 10.1124/jpet.109.154997  0.76
2009 Lountos GT, Tropea JE, Zhang D, Jobson AG, Pommier Y, Shoemaker RH, Waugh DS. Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor. Protein Science : a Publication of the Protein Society. 18: 92-100. PMID 19177354 DOI: 10.1002/pro.16  0.76
2009 Lountos GT, Austin BP, Nallamsetty S, Waugh DS. Atomic resolution structure of the cytoplasmic domain of Yersinia pestis YscU, a regulatory switch involved in type III secretion. Protein Science : a Publication of the Protein Society. 18: 467-74. PMID 19165725 DOI: 10.1002/pro.56  0.76
2009 Orville AM, Lountos GT, Finnegan S, Gadda G, Prabhakar R. Crystallographic, spectroscopic, and computational analysis of a flavin C4a-oxygen adduct in choline oxidase. Biochemistry. 48: 720-8. PMID 19133805 DOI: 10.1021/bi801918u  0.76
2008 Quaye O, Lountos GT, Fan F, Orville AM, Gadda G. Role of Glu312 in binding and positioning of the substrate for the hydride transfer reaction in choline oxidase. Biochemistry. 47: 243-56. PMID 18072756 DOI: 10.1021/bi7017943  0.76
2006 Lountos GT, Jiang R, Wellborn WB, Thaler TL, Bommarius AS, Orville AM. The crystal structure of NAD(P)H oxidase from Lactobacillus sanfranciscensis: insights into the conversion of O2 into two water molecules by the flavoenzyme. Biochemistry. 45: 9648-59. PMID 16893166 DOI: 10.1021/bi060692p  0.76
2005 Moulaei T, Maehigashi T, Lountos GT, Komeda S, Watkins D, Stone MP, Marky LA, Li JS, Gold B, Williams LD. Structure of B-DNA with cations tethered in the major groove. Biochemistry. 44: 7458-68. PMID 15895989 DOI: 10.1021/bi050128z  0.76
2005 Lountos GT, Mitchell KH, Studts JM, Fox BG, Orville AM. Crystal structures and functional studies of T4moD, the toluene 4-monooxygenase catalytic effector protein. Biochemistry. 44: 7131-42. PMID 15882052 DOI: 10.1021/bi047459g  0.76
2004 Lountos GT, Riebel BR, Wellborn WB, Bommarius AS, Orville AM. Crystallization and preliminary analysis of a water-forming NADH oxidase from Lactobacillus sanfranciscensis. Acta Crystallographica. Section D, Biological Crystallography. 60: 2044-7. PMID 15502322 DOI: 10.1107/S0907444904021171  0.76
2003 Orville AM, Studts JM, Lountos GT, Mitchell KH, Fox BG. Crystallization and preliminary analysis of native and N-terminal truncated isoforms of toluene-4-monooxygenase catalytic effector protein. Acta Crystallographica. Section D, Biological Crystallography. 59: 572-5. PMID 12595730 DOI: 10.1107/S0907444903000416  0.76
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