Ian Orme - Publications

Colorado State University, Fort Collins, CO 
Immunology, Microbiology Biology

287 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Orme IM, Henao-Tamayo MI. Trying to See the Forest through the Trees: Deciphering the Nature of Memory Immunity to. Frontiers in Immunology. 9: 461. PMID 29568298 DOI: 10.3389/Fimmu.2018.00461  1
2018 Shanley CA, Henao-Tamayo MI, Bipin C, Mugasimangalam R, Verma D, Ordway DJ, Streicher EM, Orme IM. Biology of clinical strains of Mycobacterium tuberculosis with varying levels of transmission. Tuberculosis (Edinburgh, Scotland). 109: 123-133. PMID 29559116 DOI: 10.1016/J.Tube.2018.02.003  1
2015 Henao-Tamayo MI, Obregón-Henao A, Arnett K, Shanley CA, Podell B, Orme IM, Ordway DJ. Effect of bacillus Calmette-Guérin vaccination on CD4+Foxp3+ T cells during acquired immune response to Mycobacterium tuberculosis infection. Journal of Leukocyte Biology. PMID 26590147 DOI: 10.1189/Jlb.4A0614-308Rr  0.52
2015 Henao-Tamayo M, Shanley CA, Verma D, Zilavy A, Stapleton MC, Furney SK, Podell B, Orme IM. The Efficacy of the BCG Vaccine against Newly Emerging Clinical Strains of Mycobacterium tuberculosis. Plos One. 10: e0136500. PMID 26368806 DOI: 10.1371/Journal.Pone.0136500  0.52
2015 Bai X, Shang S, Henao-Tamayo M, Basaraba RJ, Ovrutsky AR, Matsuda JL, Takeda K, Chan MM, Dakhama A, Kinney WH, Trostel J, Bai A, Honda JR, Achcar R, Hartney J, ... ... Orme I, et al. Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 112: 5111-6. PMID 25820174 DOI: 10.1073/Pnas.1424302112  0.52
2015 Robinson RT, Orme IM, Cooper AM. The onset of adaptive immunity in the mouse model of tuberculosis and the factors that compromise its expression. Immunological Reviews. 264: 46-59. PMID 25703551 DOI: 10.1111/imr.12259  0.52
2015 Iscla I, Wray R, Blount P, Larkins-Ford J, Conery AL, Ausubel FM, Ramu S, Kavanagh A, Huang JX, Blaskovich MA, Cooper MA, Obregon-Henao A, Orme I, Tjandra ES, Stroeher UH, et al. A new antibiotic with potent activity targets MscL. The Journal of Antibiotics. PMID 25649856 DOI: 10.1038/Ja.2015.4  0.52
2015 Orme IM. Tuberculosis vaccine types and timings. Clinical and Vaccine Immunology : Cvi. 22: 249-57. PMID 25540272 DOI: 10.1128/CVI.00718-14  0.52
2015 Orme IM, Robinson RT, Cooper AM. The balance between protective and pathogenic immune responses in the TB-infected lung. Nature Immunology. 16: 57-63. PMID 25521685 DOI: 10.1038/ni.3048  0.52
2015 Williams MJ, Shanley CA, Zilavy A, Peixoto B, Manca C, Kaplan G, Orme IM, Mizrahi V, Kana BD. bis-Molybdopterin guanine dinucleotide is required for persistence of Mycobacterium tuberculosis in guinea pigs. Infection and Immunity. 83: 544-50. PMID 25404027 DOI: 10.1128/IAI.02722-14  0.52
2015 Henao-Tamayo M, Obregón-Henao A, Creissen E, Shanley C, Orme I, Ordway DJ. Differential Mycobacterium bovis BCG vaccine-derived efficacy in C3Heb/FeJ and C3H/HeOuJ mice exposed to a clinical strain of Mycobacterium tuberculosis. Clinical and Vaccine Immunology : Cvi. 22: 91-8. PMID 25392011 DOI: 10.1128/Cvi.00466-14  0.52
2014 Orme IM. Vaccines to prevent tuberculosis infection rather than disease: Physiological and immunological aspects. Tuberculosis (Edinburgh, Scotland). PMID 25500316 DOI: 10.1016/j.tube.2014.10.008  0.52
2014 Orme IM, Basaraba RJ. The formation of the granuloma in tuberculosis infection. Seminars in Immunology. 26: 601-9. PMID 25453231 DOI: 10.1016/J.Smim.2014.09.009  0.52
2014 Orme I. Letter to the editor. Tuberculosis (Edinburgh, Scotland). 94: 717. PMID 25293999 DOI: 10.1016/j.tube.2014.08.004  0.52
2014 Correa AF, Bailão AM, Bastos IM, Orme IM, Soares CM, Kipnis A, Santana JM, Junqueira-Kipnis AP. The endothelin system has a significant role in the pathogenesis and progression of Mycobacterium tuberculosis infection. Infection and Immunity. 82: 5154-65. PMID 25267836 DOI: 10.1128/IAI.02304-14  0.52
2014 Henao-Tamayo M, Ordway DJ, Orme IM. Memory T cell subsets in tuberculosis: what should we be targeting? Tuberculosis (Edinburgh, Scotland). 94: 455-61. PMID 24993316 DOI: 10.1016/J.Tube.2014.05.001  0.52
2014 Orme IM, Ordway DJ. Host response to nontuberculous mycobacterial infections of current clinical importance. Infection and Immunity. 82: 3516-22. PMID 24914222 DOI: 10.1128/IAI.01606-13  0.52
2014 Podell BK, Ackart DF, Obregon-Henao A, Eck SP, Henao-Tamayo M, Richardson M, Orme IM, Ordway DJ, Basaraba RJ. Increased severity of tuberculosis in Guinea pigs with type 2 diabetes: a model of diabetes-tuberculosis comorbidity. The American Journal of Pathology. 184: 1104-18. PMID 24492198 DOI: 10.1016/J.Ajpath.2013.12.015  0.52
2014 Ackart DF, Hascall-Dove L, Caceres SM, Kirk NM, Podell BK, Melander C, Orme IM, Leid JG, Nick JA, Basaraba RJ. Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis Pathogens and Disease. 70: 359-369. PMID 24478060 DOI: 10.1111/2049-632X.12144  0.52
2014 Shanley CA, Ireton GC, Baldwin SL, Coler RN, Reed SG, Basaraba RJ, Orme IM. Therapeutic vaccination against relevant high virulence clinical isolates of Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland). 94: 140-7. PMID 24295653 DOI: 10.1016/J.Tube.2013.08.010  0.52
2014 Orme IM. A new unifying theory of the pathogenesis of tuberculosis. Tuberculosis (Edinburgh, Scotland). 94: 8-14. PMID 24157189 DOI: 10.1016/j.tube.2013.07.004  0.52
2013 Obregón-Henao A, Henao-Tamayo M, Orme IM, Ordway DJ. Gr1(int)CD11b+ myeloid-derived suppressor cells in Mycobacterium tuberculosis infection. Plos One. 8: e80669. PMID 24224058 DOI: 10.1371/Journal.Pone.0080669  0.52
2013 Shanley CA, Streicher EM, Warren RM, Victor TC, Orme IM. Characterization of W-Beijing isolates of Mycobacterium tuberculosis from the Western Cape. Vaccine. 31: 5934-9. PMID 24144471 DOI: 10.1016/j.vaccine.2013.10.044  0.52
2013 Sun J, Singh V, Lau A, Stokes RW, Obregón-Henao A, Orme IM, Wong D, Av-Gay Y, Hmama Z. Mycobacterium tuberculosis nucleoside diphosphate kinase inactivates small GTPases leading to evasion of innate immunity. Plos Pathogens. 9: e1003499. PMID 23874203 DOI: 10.1371/Journal.Ppat.1003499  0.52
2013 Orme IM. Vaccine development for tuberculosis: current progress. Drugs. 73: 1015-24. PMID 23794129 DOI: 10.1007/s40265-013-0081-8  0.52
2012 Kato-Maeda M, Shanley CA, Ackart D, Jarlsberg LG, Shang S, Obregon-Henao A, Harton M, Basaraba RJ, Henao-Tamayo M, Barrozo JC, Rose J, Kawamura LM, Coscolla M, Fofanov VY, Koshinsky H, ... ... Orme IM, et al. Beijing sublineages of Mycobacterium tuberculosis differ in pathogenicity in the guinea pig. Clinical and Vaccine Immunology : Cvi. 19: 1227-37. PMID 22718126 DOI: 10.1128/Cvi.00250-12  0.52
2012 Palanisamy GS, Kirk NM, Ackart DF, Obregón-Henao A, Shanley CA, Orme IM, Basaraba RJ. Uptake and accumulation of oxidized low-density lipoprotein during mycobacterium tuberculosis infection in guinea pigs Plos One. 7. PMID 22493658 DOI: 10.1371/Journal.Pone.0034148  0.52
2012 Henao-Tamayo M, Obregón-Henao A, Ordway DJ, Shang S, Duncan CG, Orme IM. A mouse model of tuberculosis reinfection. Tuberculosis (Edinburgh, Scotland). 92: 211-7. PMID 22429719 DOI: 10.1016/J.Tube.2012.02.008  0.52
2012 Shang S, Shanley CA, Caraway ML, Orme EA, Henao-Tamayo M, Hascall-Dove L, Ackart D, Orme IM, Ordway DJ, Basaraba RJ. Drug treatment combined with BCG vaccination reduces disease reactivation in guinea pigs infected with Mycobacterium tuberculosis. Vaccine. 30: 1572-82. PMID 22244979 DOI: 10.1016/J.Vaccine.2011.12.114  0.52
2012 De Groote MA, Gruppo V, Woolhiser LK, Orme IM, Gilliland JC, Lenaerts AJ. Importance of confirming data on the in vivo efficacy of novel antibacterial drug regimens against various strains of Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 56: 731-8. PMID 22143517 DOI: 10.1128/AAC.05701-11  0.32
2011 Honda JR, Shang S, Shanley CA, Caraway ML, Henao-Tamayo M, Chan ED, Basaraba RJ, Orme IM, Ordway DJ, Flores SC. Immune Responses of HIV-1 Tat Transgenic Mice to Mycobacterium Tuberculosis W-Beijing SA161. The Open Aids Journal. 5: 86-95. PMID 22046211 DOI: 10.2174/1874613601105010086  0.52
2011 Palanisamy GS, Kirk NM, Ackart DF, Shanley CA, Orme IM, Basaraba RJ. Evidence for oxidative stress and defective antioxidant response in guinea pigs with tuberculosis Plos One. 6. PMID 22028843 DOI: 10.1371/Journal.Pone.0026254  0.52
2011 Sweeney KA, Dao DN, Goldberg MF, Hsu T, Venkataswamy MM, Henao-Tamayo M, Ordway D, Sellers RS, Jain P, Chen B, Chen M, Kim J, Lukose R, Chan J, Orme IM, et al. A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis. Nature Medicine. 17: 1261-8. PMID 21892180 DOI: 10.1038/Nm.2420  0.52
2011 Ching LK, Mompoint F, Guderian JA, Picone A, Orme IM, Coler RN, Reed SG, Baldwin SL. Transcriptional profiling of TLR-4/7/8-stimulated guinea pig splenocytes and whole blood by bDNA assay. Journal of Immunological Methods. 373: 54-62. PMID 21839740 DOI: 10.1016/j.jim.2011.07.021  0.52
2011 Ordway DJ, Orme IM. Animal models of mycobacteria infection. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit19.5. PMID 21809318 DOI: 10.1002/0471142735.im1905s94  0.52
2011 Ordway DJ, Shang S, Henao-Tamayo M, Obregon-Henao A, Nold L, Caraway M, Shanley CA, Basaraba RJ, Duncan CG, Orme IM. Mycobacterium bovis BCG-mediated protection against W-Beijing strains of Mycobacterium tuberculosis is diminished concomitant with the emergence of regulatory T cells. Clinical and Vaccine Immunology : Cvi. 18: 1527-35. PMID 21795460 DOI: 10.1128/Cvi.05127-11  0.52
2011 Shang S, Harton M, Tamayo MH, Shanley C, Palanisamy GS, Caraway M, Chan ED, Basaraba RJ, Orme IM, Ordway DJ. Increased Foxp3 expression in guinea pigs infected with W-Beijing strains of M. tuberculosis. Tuberculosis (Edinburgh, Scotland). 91: 378-85. PMID 21737349 DOI: 10.1016/J.Tube.2011.06.001  0.52
2011 Henao-Tamayo M, Irwin SM, Shang S, Ordway D, Orme IM. T lymphocyte surface expression of exhaustion markers as biomarkers of the efficacy of chemotherapy for tuberculosis. Tuberculosis (Edinburgh, Scotland). 91: 308-13. PMID 21530406 DOI: 10.1016/J.Tube.2011.04.001  0.52
2011 Obregón-Henao A, Shanley C, Bianco MV, Cataldi AA, Basaraba RJ, Orme IM, Bigi F. Vaccination of guinea pigs using mce operon mutants of Mycobacterium tuberculosis. Vaccine. 29: 4302-7. PMID 21515327 DOI: 10.1016/J.Vaccine.2011.04.027  0.52
2011 Dharmadhikari AS, Basaraba RJ, Van Der Walt ML, Weyer K, Mphahlele M, Venter K, Jensen PA, First MW, Parsons S, McMurray DN, Orme IM, Nardell EA. Natural infection of guinea pigs exposed to patients with highly drug-resistant tuberculosis. Tuberculosis (Edinburgh, Scotland). 91: 329-38. PMID 21478054 DOI: 10.1016/J.Tube.2011.03.002  0.52
2011 Orme IM. Development of new vaccines and drugs for TB: limitations and potential strategic errors. Future Microbiology. 6: 161-77. PMID 21366417 DOI: 10.2217/fmb.10.168  0.52
2011 Shang S, Ordway D, Henao-Tamayo M, Bai X, Oberley-Deegan R, Shanley C, Orme IM, Case S, Minor M, Ackart D, Hascall-Dove L, Ovrutsky AR, Kandasamy P, Voelker DR, Lambert C, et al. Cigarette smoke increases susceptibility to tuberculosis--evidence from in vivo and in vitro models. The Journal of Infectious Diseases. 203: 1240-8. PMID 21357942 DOI: 10.1093/Infdis/Jir009  0.52
2011 Rosas-Taraco AG, Higgins DM, Sánchez-Campillo J, Lee EJ, Orme IM, González-Juarrero M. Local pulmonary immunotherapy with siRNA targeting TGFβ1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice. Tuberculosis (Edinburgh, Scotland). 91: 98-106. PMID 21195670 DOI: 10.1016/J.Tube.2010.11.004  0.52
2011 De Groote MA, Gilliland JC, Wells CL, Brooks EJ, Woolhiser LK, Gruppo V, Peloquin CA, Orme IM, Lenaerts AJ. Comparative studies evaluating mouse models used for efficacy testing of experimental drugs against Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 55: 1237-47. PMID 21135176 DOI: 10.1128/AAC.00595-10  0.52
2011 Shang S, Shanley CA, Caraway ML, Orme EA, Henao-Tamayo M, Hascall-Dove L, Ackart D, Lenaerts AJ, Basaraba RJ, Orme IM, Ordway DJ. Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs. Antimicrobial Agents and Chemotherapy. 55: 124-31. PMID 20937788 DOI: 10.1128/Aac.00978-10  0.52
2010 Bertholet S, Ireton GC, Ordway DJ, Windish HP, Pine SO, Kahn M, Phan T, Orme IM, Vedvick TS, Baldwin SL, Coler RN, Reed SG. A defined tuberculosis vaccine candidate boosts BCG and protects against multidrug-resistant Mycobacterium tuberculosis. Science Translational Medicine. 2: 53ra74. PMID 20944089 DOI: 10.1126/scitranslmed.3001094  0.52
2010 Orme IM. The Achilles heel of BCG. Tuberculosis (Edinburgh, Scotland). 90: 329-32. PMID 20659816 DOI: 10.1016/j.tube.2010.06.002  0.52
2010 Redente EF, Higgins DM, Dwyer-Nield LD, Orme IM, Gonzalez-Juarrero M, Malkinson AM. Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation. Journal of Leukocyte Biology. 88: 159-68. PMID 20360403 DOI: 10.1189/Jlb.0609378  0.52
2010 Ordway DJ, Shanley CA, Caraway ML, Orme EA, Bucy DS, Hascall-Dove L, Henao-Tamayo M, Harton MR, Shang S, Ackart D, Kraft SL, Lenaerts AJ, Basaraba RJ, Orme IM. Evaluation of standard chemotherapy in the guinea pig model of tuberculosis. Antimicrobial Agents and Chemotherapy. 54: 1820-33. PMID 20160055 DOI: 10.1128/Aac.01521-09  0.52
2010 Henao-Tamayo MI, Ordway DJ, Irwin SM, Shang S, Shanley C, Orme IM. Phenotypic definition of effector and memory T-lymphocyte subsets in mice chronically infected with Mycobacterium tuberculosis. Clinical and Vaccine Immunology : Cvi. 17: 618-25. PMID 20107011 DOI: 10.1128/Cvi.00368-09  0.52
2010 Chan ED, Bai X, Kartalija M, Orme IM, Ordway DJ. Host immune response to rapidly growing mycobacteria, an emerging cause of chronic lung disease. American Journal of Respiratory Cell and Molecular Biology. 43: 387-93. PMID 20081053 DOI: 10.1165/rcmb.2009-0276TR  0.52
2009 Sharpe SA, Eschelbach E, Basaraba RJ, Gleeson F, Hall GA, McIntyre A, Williams A, Kraft SL, Clark S, Gooch K, Hatch G, Orme IM, Marsh PD, Dennis MJ. Determination of lesion volume by MRI and stereology in a macaque model of tuberculosis. Tuberculosis (Edinburgh, Scotland). 89: 405-16. PMID 19879805 DOI: 10.1016/J.Tube.2009.09.002  0.52
2009 Williams A, Hall Y, Orme IM. Evaluation of new vaccines for tuberculosis in the guinea pig model. Tuberculosis (Edinburgh, Scotland). 89: 389-97. PMID 19815462 DOI: 10.1016/j.tube.2009.08.004  0.52
2009 Early MA, Lishnevsky M, Gilchrist JM, Higgins DM, Orme IM, Muller WA, Gonzalez-Juarerro M, Schenkel AR. Non-invasive diagnosis of early pulmonary disease in PECAM-deficient mice using infrared pulse oximetry. Experimental and Molecular Pathology. 87: 152-8. PMID 19646434 DOI: 10.1016/J.Yexmp.2009.07.008  0.52
2009 Orme IM. Potential complications to TB vaccine testing in animal models. Indian Journal of Experimental Biology. 47: 440-4. PMID 19634708  0.52
2009 Drumm JE, Mi K, Bilder P, Sun M, Lim J, Bielefeldt-Ohmann H, Basaraba R, So M, Zhu G, Tufariello JM, Izzo AA, Orme IM, Almo SC, Leyh TS, Chan J. Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-Binding: requirement for establishing chronic persistent infection. Plos Pathogens. 5: e1000460. PMID 19478878 DOI: 10.1371/Journal.Ppat.1000460  0.52
2009 Henao-Tamayo M, Palaniswamy GS, Smith EE, Shanley CA, Wang B, Orme IM, Basaraba RJ, DuTeau NM, Ordway D. Post-exposure vaccination against Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland). 89: 142-8. PMID 19264552 DOI: 10.1016/J.Tube.2009.01.002  0.52
2009 Palanisamy GS, DuTeau N, Eisenach KD, Cave DM, Theus SA, Kreiswirth BN, Basaraba RJ, Orme IM. Clinical strains of Mycobacterium tuberculosis display a wide range of virulence in guinea pigs. Tuberculosis (Edinburgh, Scotland). 89: 203-9. PMID 19251482 DOI: 10.1016/J.Tube.2009.01.005  0.52
2009 Higgins DM, Sanchez-Campillo J, Rosas-Taraco AG, Lee EJ, Orme IM, Gonzalez-Juarrero M. Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection. Tuberculosis (Edinburgh, Scotland). 89: 149-57. PMID 19213603 DOI: 10.1016/J.Tube.2009.01.001  0.52
2009 Reed SG, Coler RN, Dalemans W, Dalemans W, Tan EV, DeLa Cruz EC, Basaraba RJ, Orme IM, Skeiky YA, Alderson MR, Cowgill KD, Prieels JP, Abalos RM, Dubois MC, Cohen J, et al. Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys. Proceedings of the National Academy of Sciences of the United States of America. 106: 2301-6. PMID 19188599 DOI: 10.1073/Pnas.0712077106  0.52
2009 Rosas-Taraco AG, Higgins DM, Sánchez-Campillo J, Lee EJ, Orme IM, González-Juarrero M. Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis. American Journal of Respiratory Cell and Molecular Biology. 41: 136-45. PMID 19097989 DOI: 10.1165/Rcmb.2008-0363Oc  0.52
2009 Coler RN, Dillon DC, Skeiky YA, Kahn M, Orme IM, Lobet Y, Reed SG, Alderson MR. Identification of Mycobacterium tuberculosis vaccine candidates using human CD4+ T-cells expression cloning. Vaccine. 27: 223-33. PMID 19000730 DOI: 10.1016/j.vaccine.2008.10.056  0.52
2009 Woolhiser LK, Hoff DR, Marietta KS, Orme IM, Lenaerts AJ. Testing of experimental compounds in a relapse model of tuberculosis using granulocyte-macrophage colony-stimulating factor gene-disrupted mice. Antimicrobial Agents and Chemotherapy. 53: 306-8. PMID 18852269 DOI: 10.1128/AAC.01346-07  0.52
2009 Gonzalez-Juarrero M, Kingry LC, Ordway DJ, Henao-Tamayo M, Harton M, Basaraba RJ, Hanneman WH, Orme IM, Slayden RA. Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease. American Journal of Respiratory Cell and Molecular Biology. 40: 398-409. PMID 18787176 DOI: 10.1165/Rcmb.2008-0248Oc  0.52
2008 El Kasmi KC, Qualls JE, Pesce JT, Smith AM, Thompson RW, Henao-Tamayo M, Basaraba RJ, König T, Schleicher U, Koo MS, Kaplan G, Fitzgerald KA, Tuomanen EI, Orme IM, Kanneganti TD, et al. Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nature Immunology. 9: 1399-406. PMID 18978793 DOI: 10.1038/Ni.1671  0.52
2008 Hoff DR, Caraway ML, Brooks EJ, Driver ER, Ryan GJ, Peloquin CA, Orme IM, Basaraba RJ, Lenaerts AJ. Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 52: 4137-40. PMID 18694944 DOI: 10.1128/Aac.00196-08  0.52
2008 Ordway D, Henao-Tamayo M, Shanley C, Smith EE, Palanisamy G, Wang B, Basaraba RJ, Orme IM. Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis. Clinical and Vaccine Immunology : Cvi. 15: 1248-58. PMID 18508930 DOI: 10.1128/Cvi.00019-08  0.52
2008 Higgins DM, Sanchez-Campillo J, Rosas-Taraco AG, Higgins JR, Lee EJ, Orme IM, Gonzalez-Juarrero M. Relative levels of M-CSF and GM-CSF influence the specific generation of macrophage populations during infection with Mycobacterium tuberculosis. Journal of Immunology (Baltimore, Md. : 1950). 180: 4892-900. PMID 18354213 DOI: 10.4049/Jimmunol.180.7.4892  0.52
2008 Palanisamy GS, Smith EE, Shanley CA, Ordway DJ, Orme IM, Basaraba RJ. Disseminated disease severity as a measure of virulence of Mycobacterium tuberculosis in the guinea pig model. Tuberculosis (Edinburgh, Scotland). 88: 295-306. PMID 18321783 DOI: 10.1016/J.Tube.2007.12.003  0.52
2008 Ordway D, Henao-Tamayo M, Smith E, Shanley C, Harton M, Troudt J, Bai X, Basaraba RJ, Orme IM, Chan ED. Animal model of Mycobacterium abscessus lung infection. Journal of Leukocyte Biology. 83: 1502-11. PMID 18310351 DOI: 10.1189/Jlb.1007696  0.52
2008 Lenaerts AJ, Bitting C, Woolhiser L, Gruppo V, Marietta KS, Johnson CM, Orme IM. Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo. Antimicrobial Agents and Chemotherapy. 52: 1513-5. PMID 18268091 DOI: 10.1128/AAC.00897-07  0.32
2008 Lenaerts AJ, Degroote MA, Orme IM. Preclinical testing of new drugs for tuberculosis: current challenges. Trends in Microbiology. 16: 48-54. PMID 18182291 DOI: 10.1016/j.tim.2007.12.002  0.52
2008 Basaraba RJ, Bielefeldt-Ohmann H, Eschelbach EK, Reisenhauer C, Tolnay AE, Taraba LC, Shanley CA, Smith EA, Bedwell CL, Chlipala EA, Orme IM. Increased expression of host iron-binding proteins precedes iron accumulation and calcification of primary lung lesions in experimental tuberculosis in the guinea pig. Tuberculosis (Edinburgh, Scotland). 88: 69-79. PMID 17942369 DOI: 10.1016/J.Tube.2007.09.002  0.52
2007 Orme I, Gonzalez-Juarrero M. Animal models of M. tuberculosis Infection. Current Protocols in Microbiology. Unit 10A.5. PMID 18770606 DOI: 10.1002/9780471729259.Mc10A05S7  0.52
2007 Henao-Tamayo M, Junqueira-Kipnis AP, Ordway D, Gonzales-Juarrero M, Stewart GR, Young DB, Wilkinson RJ, Basaraba RJ, Orme IM. A mutant of Mycobacterium tuberculosis lacking the 19-kDa lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic properties. Vaccine. 25: 7153-9. PMID 17804126 DOI: 10.1016/J.Vaccine.2007.07.042  0.52
2007 Ordway D, Higgins DM, Sanchez-Campillo J, Spencer JS, Henao-Tamayo M, Harton M, Orme IM, Gonzalez Juarrero M. XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-gamma by CD4 T cells and participates in granuloma stability. Journal of Leukocyte Biology. 82: 1221-9. PMID 17699612 DOI: 10.1189/Jlb.0607426  0.52
2007 Ordway D, Palanisamy G, Henao-Tamayo M, Smith EE, Shanley C, Orme IM, Basaraba RJ. The cellular immune response to Mycobacterium tuberculosis infection in the guinea pig. Journal of Immunology (Baltimore, Md. : 1950). 179: 2532-41. PMID 17675515 DOI: 10.4049/Jimmunol.179.4.2532  0.52
2007 Hinchey J, Lee S, Jeon BY, Basaraba RJ, Venkataswamy MM, Chen B, Chan J, Braunstein M, Orme IM, Derrick SC, Morris SL, Jacobs WR, Porcelli SA. Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis. The Journal of Clinical Investigation. 117: 2279-88. PMID 17671656 DOI: 10.1172/Jci31947  0.52
2007 Wang B, Henao-Tamayo M, Harton M, Ordway D, Shanley C, Basaraba RJ, Orme IM. A Toll-like receptor-2-directed fusion protein vaccine against tuberculosis. Clinical and Vaccine Immunology : Cvi. 14: 902-6. PMID 17616633 DOI: 10.1128/Cvi.00077-07  0.52
2007 Ordway D, Henao-Tamayo M, Harton M, Palanisamy G, Troudt J, Shanley C, Basaraba RJ, Orme IM. The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulation. Journal of Immunology (Baltimore, Md. : 1950). 179: 522-31. PMID 17579073 DOI: 10.4049/Jimmunol.179.1.522  0.52
2007 Lenaerts AJ, Hoff D, Aly S, Ehlers S, Andries K, Cantarero L, Orme IM, Basaraba RJ. Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910. Antimicrobial Agents and Chemotherapy. 51: 3338-45. PMID 17517834 DOI: 10.1128/Aac.00276-07  0.52
2007 Woolhiser L, Tamayo MH, Wang B, Gruppo V, Belisle JT, Lenaerts AJ, Basaraba RJ, Orme IM. In vivo adaptation of the Wayne model of latent tuberculosis. Infection and Immunity. 75: 2621-5. PMID 17283091 DOI: 10.1128/Iai.00918-06  0.52
2007 Derrick SC, Evering TH, Sambandamurthy VK, Jalapathy KV, Hsu T, Chen B, Chen M, Russell RG, Junqueira-Kipnis AP, Orme IM, Porcelli SA, Jacobs WR, Morris SL. Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine. Immunology. 120: 192-206. PMID 17076705 DOI: 10.1111/J.1365-2567.2006.02491.X  0.52
2006 Junqueira-Kipnis AP, Basaraba RJ, Gruppo V, Palanisamy G, Turner OC, Hsu T, Jacobs WR, Fulton SA, Reba SM, Boom WH, Orme IM. Mycobacteria lacking the RD1 region do not induce necrosis in the lungs of mice lacking interferon-gamma. Immunology. 119: 224-31. PMID 17005003 DOI: 10.1111/J.1365-2567.2006.02427.X  0.52
2006 Taylor JL, Hattle JM, Dreitz SA, Troudt JM, Izzo LS, Basaraba RJ, Orme IM, Matrisian LM, Izzo AA. Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection. Infection and Immunity. 74: 6135-44. PMID 16982845 DOI: 10.1128/Iai.02048-05  0.52
2006 Basaraba RJ, Smith EE, Shanley CA, Orme IM. Pulmonary lymphatics are primary sites of Mycobacterium tuberculosis infection in guinea pigs infected by aerosol. Infection and Immunity. 74: 5397-401. PMID 16926435 DOI: 10.1128/Iai.00332-06  0.52
2006 Ordway D, Harton M, Henao-Tamayo M, Montoya R, Orme IM, Gonzalez-Juarrero M. Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis. Journal of Immunology (Baltimore, Md. : 1950). 176: 4931-9. PMID 16585589 DOI: 10.4049/Jimmunol.176.8.4931  0.52
2006 Gruppo V, Johnson CM, Marietta KS, Scherman H, Zink EE, Crick DC, Adams LB, Orme IM, Lenaerts AJ. Rapid microbiologic and pharmacologic evaluation of experimental compounds against Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 50: 1245-50. PMID 16569835 DOI: 10.1128/AAC.50.4.1245-1250.2006  0.52
2006 Basaraba RJ, Dailey DD, McFarland CT, Shanley CA, Smith EE, McMurray DN, Orme IM. Lymphadenitis as a major element of disease in the guinea pig model of tuberculosis. Tuberculosis (Edinburgh, Scotland). 86: 386-94. PMID 16473044 DOI: 10.1016/J.Tube.2005.11.003  0.52
2006 Park JS, Tamayo MH, Gonzalez-Juarrero M, Orme IM, Ordway DJ. Virulent clinical isolates of Mycobacterium tuberculosis grow rapidly and induce cellular necrosis but minimal apoptosis in murine macrophages. Journal of Leukocyte Biology. 79: 80-6. PMID 16275894 DOI: 10.1189/Jlb.0505250  0.52
2006 Orme IM. Safety issues regarding new vaccines for tuberculosis, with an emphasis on post-exposure vaccination. Tuberculosis (Edinburgh, Scotland). 86: 68-73. PMID 16260181 DOI: 10.1016/j.tube.2005.07.002  0.52
2006 Basaraba RJ, Izzo AA, Brandt L, Orme IM. Decreased survival of guinea pigs infected with Mycobacterium tuberculosis after multiple BCG vaccinations. Vaccine. 24: 280-6. PMID 16153758 DOI: 10.1016/J.Vaccine.2005.07.103  0.52
2006 Orme IM. Preclinical testing of new vaccines for tuberculosis: a comprehensive review. Vaccine. 24: 2-19. PMID 16139397 DOI: 10.1016/j.vaccine.2005.07.078  0.52
2005 Orme IM. Tuberculosis vaccines: current progress. Drugs. 65: 2437-44. PMID 16296870 DOI: 10.2165/00003495-200565170-00002  0.52
2005 Kipnis A, Irwin S, Izzo AA, Basaraba RJ, Orme IM. Memory T lymphocytes generated by Mycobacterium bovis BCG vaccination reside within a CD4 CD44lo CD62 ligand(hi) population. Infection and Immunity. 73: 7759-64. PMID 16239580 DOI: 10.1128/Iai.73.11.7759-7764.2005  0.52
2005 St Amand AL, Frank DN, De Groote MA, Basaraba RJ, Orme IM, Pace NR. Use of specific rRNA oligonucleotide probes for microscopic detection of Mycobacterium tuberculosis in culture and tissue specimens. Journal of Clinical Microbiology. 43: 5369-71. PMID 16208021 DOI: 10.1128/Jcm.43.10.5369-5371.2005  0.52
2005 Johnson CM, Pandey R, Sharma S, Khuller GK, Basaraba RJ, Orme IM, Lenaerts AJ. Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 49: 4335-8. PMID 16189115 DOI: 10.1128/Aac.49.10.4335-4338.2005  0.52
2005 Ordway D, Henao-Tamayo M, Orme IM, Gonzalez-Juarrero M. Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-associated factor family. Journal of Immunology (Baltimore, Md. : 1950). 175: 3873-81. PMID 16148133 DOI: 10.4049/Jimmunol.175.6.3873  0.52
2005 Irwin SM, Izzo AA, Dow SW, Skeiky YA, Reed SG, Alderson MR, Orme IM. Tracking antigen-specific CD8 T lymphocytes in the lungs of mice vaccinated with the Mtb72F polyprotein. Infection and Immunity. 73: 5809-16. PMID 16113299 DOI: 10.1128/IAI.73.9.5809-5816.2005  0.52
2005 Taylor JL, Ordway DJ, Troudt J, Gonzalez-Juarrero M, Basaraba RJ, Orme IM. Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA. Infection and Immunity. 73: 5189-93. PMID 16041037 DOI: 10.1128/Iai.73.8.5189-5193.2005  0.52
2005 Lenaerts AJ, Johnson CM, Marrieta KS, Gruppo V, Orme IM. Significant increases in the levels of liver enzymes in mice treated with anti-tuberculosis drugs. International Journal of Antimicrobial Agents. 26: 152-8. PMID 15953708 DOI: 10.1016/j.ijantimicag.2005.04.011  0.52
2005 Lenaerts AJ, Gruppo V, Marietta KS, Johnson CM, Driscoll DK, Tompkins NM, Rose JD, Reynolds RC, Orme IM. Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models. Antimicrobial Agents and Chemotherapy. 49: 2294-301. PMID 15917524 DOI: 10.1128/AAC.49.6.2294-2301.2005  0.52
2005 Skeiky YA, Alderson MR, Ovendale PJ, Lobet Y, Dalemans W, Orme IM, Reed SG, Campos-Neto A. Protection of mice and guinea pigs against tuberculosis induced by immunization with a single Mycobacterium tuberculosis recombinant antigen, MTB41. Vaccine. 23: 3937-45. PMID 15917115 DOI: 10.1016/j.vaccine.2005.03.003  0.52
2005 Junqueira-Kipnis AP, Kipnis A, Henao Tamayo M, Harton M, Gonzalez Juarrero M, Basaraba RJ, Orme IM. Interleukin-10 production by lung macrophages in CBA xid mutant mice infected with Mycobacterium tuberculosis. Immunology. 115: 246-52. PMID 15885131 DOI: 10.1111/J.1365-2567.2005.02136.X  0.52
2005 Orme IM. The use of animal models to guide rational vaccine design. Microbes and Infection / Institut Pasteur. 7: 905-10. PMID 15878834 DOI: 10.1016/j.micinf.2005.03.008  0.52
2005 Gonzalez-Juarrero M, Hattle JM, Izzo A, Junqueira-Kipnis AP, Shim TS, Trapnell BC, Cooper AM, Orme IM. Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection. Journal of Leukocyte Biology. 77: 914-22. PMID 15767289 DOI: 10.1189/Jlb.1204723  0.52
2005 Orme IM. Current progress in tuberculosis vaccine development Vaccine. 23: 2105-2108. PMID 15755579 DOI: 10.1016/j.vaccine.2005.01.062  0.52
2005 Aldwell FE, Brandt L, Fitzpatrick C, Orme IM. Mice fed lipid-encapsulated Mycobacterium bovis BCG are protected against aerosol challenge with Mycobactenum tuberculosis Infection and Immunity. 73: 1903-1905. PMID 15731098 DOI: 10.1128/IAI.73.3.1903-1905.2005  0.52
2005 Izzo A, Brandt L, Lasco T, Kipnis AP, Orme I. NIH pre-clinical screening program: overview and current status. Tuberculosis (Edinburgh, Scotland). 85: 25-8. PMID 15687024 DOI: 10.1016/J.Tube.2004.09.008  0.52
2005 Orme IM. Mouse and guinea pig models for testing new tuberculosis vaccines Tuberculosis. 85: 13-17. PMID 15687022 DOI: 10.1016/j.tube.2004.08.001  0.52
2005 Orme IM. New vaccines for tuberculosis Modern Aspects of Immunobiology. 17: 4.  0.52
2004 Lenaerts AJ, Chapman PL, Orme IM. Statistical limitations to the Cornell model of latent tuberculosis infection for the study of relapse rates Tuberculosis. 84: 361-364. PMID 15525559 DOI: 10.1016/j.tube.2004.03.002  0.52
2004 Brandt L, Skeiky YA, Alderson MR, Lobet Y, Dalemans W, Turner OC, Basaraba RJ, Izzo AA, Lasco TM, Chapman PL, Reed SG, Orme IM. The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigs. Infection and Immunity. 72: 6622-32. PMID 15501795 DOI: 10.1128/Iai.72.11.6622-6632.2004  0.52
2004 Kraft SL, Dailey D, Kovach M, Stasiak KL, Bennett J, McFarland CT, McMurray DN, Izzo AA, Orme IM, Basaraba RJ. Magnetic resonance imaging of pulmonary lesions in guinea pigs infected with Mycobacterium tuberculosis. Infection and Immunity. 72: 5963-71. PMID 15385500 DOI: 10.1128/Iai.72.10.5963-5971.2004  0.52
2004 Vesosky B, Turner OC, Turner J, Orme IM. Gamma interferon production by bovine gamma delta T cells following stimulation with mycobacterial mycolylarabinogalactan peptidoglycan. Infection and Immunity. 72: 4612-8. PMID 15271921 DOI: 10.1128/Iai.72.8.4612-4618.2004  0.52
2004 Turner J, Dobos KM, Keen MA, Frank AA, Ehlers S, Orme IM, Belisle JT, Cooper AM. A limited antigen-specific cellular response is sufficient for the early control of Mycobacterium tuberculosis in the lung but is insufficient for long-term survival. Infection and Immunity. 72: 3759-68. PMID 15213116 DOI: 10.1128/Iai.72.7.3759-3768.2004  0.52
2004 Skeiky YAW, Alderson MR, Ovendale PJ, Guderian JA, Brandt L, Dillon DC, Campos-Neto A, Lobet Y, Dalemans W, Orme IM, Reed SG. Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein Journal of Immunology. 172: 7618-7628. PMID 15187142 DOI: 10.4049/jimmunol.172.12.7618  0.52
2004 Orme I. Adaptive immunity to mycobacteria Current Opinion in Microbiology. 7: 58-61. PMID 15036141 DOI: 10.1016/J.Mib.2003.11.002  0.52
2004 Wu S, Howard ST, Lakey DL, Kipnis A, Samten B, Safi H, Gruppo V, Wizel B, Shams H, Basaraba RJ, Orme IM, Barnes PF. The principal sigma factor sigA mediates enhanced growth of Mycobacterium tuberculosis in vivo Molecular Microbiology. 51: 1551-1562. PMID 15009884 DOI: 10.1111/J.1365-2958.2003.03922.X  0.52
2004 Dobos KM, Spencer JS, Orme IM, Belisle JT. Proteomic approaches to antigen discovery. Methods in Molecular Medicine. 94: 3-17. PMID 14959819 DOI: 10.1385/1-59259-679-7:3  0.52
2004 Lasco TM, Turner OC, Cassone L, Sugawara I, Yamada H, McMurray DN, Orme IM. Rapid accumulation of eosinophils in lung lesions in guinea pigs infected with Mycobacterium tuberculosis. Infection and Immunity. 72: 1147-9. PMID 14742563 DOI: 10.1128/Iai.72.2.1147-1149.2004  0.52
2004 Hsieh MJ, Junqueira-Kipnis AP, Hoeffer A, Turner OC, Orme IM. Incorporation of CpG oligodeoxynucleotide fails to enhance the protective efficacy of a subunit vaccine against Mycobacterium tuberculosis. Vaccine. 22: 655-9. PMID 14741157 DOI: 10.1016/J.Vaccine.2003.08.035  0.52
2004 Turner J, Orme IM. The expression of early resistance to an infection with Mycobacterium tuberculosis by old mice is dependent on IFN type II (IFN-gamma) but not IFN type I. Mechanisms of Ageing and Development. 125: 1-9. PMID 14706232 DOI: 10.1016/J.Mad.2003.09.002  0.52
2004 Junqueira-Kipnis AP, Turner J, Gonzalez-Juarrero M, Turner OC, Orme IM. Stable T-cell population expressing an effector cell surface phenotype in the lungs of mice chronically infected with Mycobacterium tuberculosis. Infection and Immunity. 72: 570-5. PMID 14688138 DOI: 10.1128/Iai.72.1.570-575.2004  0.52
2003 Junqueira-Kipnis AP, Kipnis A, Jamieson A, Juarrero MG, Diefenbach A, Raulet DH, Turner J, Orme IM. NK cells respond to pulmonary infection with Mycobacterium tuberculosis, but play a minimal role in protection. Journal of Immunology (Baltimore, Md. : 1950). 171: 6039-45. PMID 14634116 DOI: 10.4049/Jimmunol.171.11.6039  0.52
2003 Shim TS, Turner OC, Orme IM. Toll-like receptor 4 plays no role in susceptibility of mice to Mycobacterium tuberculosis infection. Tuberculosis (Edinburgh, Scotland). 83: 367-71. PMID 14623167 DOI: 10.1016/S1472-9792(03)00071-4  0.52
2003 Turner J, Turner OC, Baird N, Orme IM, Wilcox CL, Baldwin SL. Influence of increased age on the development of herpes stromal keratitis. Experimental Gerontology. 38: 1205-12. PMID 14580874 DOI: 10.1016/S0531-5565(03)00187-6  0.52
2003 Kipnis A, Basaraba RJ, Turner J, Orme IM. Increased neutrophil influx but no impairment of protective immunity to tuberculosis in mice lacking the CD44 molecule. Journal of Leukocyte Biology. 74: 992-7. PMID 12972514 DOI: 10.1189/Jlb.0603301  0.52
2003 Gonzalez-Juarrero M, Shim TS, Kipnis A, Junqueira-Kipnis AP, Orme IM. Dynamics of macrophage cell populations during murine pulmonary tuberculosis. Journal of Immunology (Baltimore, Md. : 1950). 171: 3128-35. PMID 12960339 DOI: 10.4049/Jimmunol.171.6.3128  0.52
2003 Turner OC, Keefe RG, Sugawara I, Yamada H, Orme IM. SWR mice are highly susceptible to pulmonary infection with Mycobacterium tuberculosis. Infection and Immunity. 71: 5266-72. PMID 12933873 DOI: 10.1128/Iai.71.9.5266-5272.2003  0.52
2003 Rousseau C, Turner OC, Rush E, Bordat Y, Sirakova TD, Kolattukudy PE, Ritter S, Orme IM, Gicquel B, Jackson M. Sulfolipid deficiency does not affect the virulence of Mycobacterium tuberculosis H37Rv in mice and guinea pigs. Infection and Immunity. 71: 4684-90. PMID 12874349 DOI: 10.1128/Iai.71.8.4684-4690.2003  0.52
2003 Kipnis A, Basaraba RJ, Orme IM, Cooper AM. Role of chemokine ligand 2 in the protective response to early murine pulmonary tuberculosis. Immunology. 109: 547-51. PMID 12871221 DOI: 10.1046/J.1365-2567.2003.01680.X  0.52
2003 Orme IM. The mouse as a useful model of tuberculosis Tuberculosis. 83: 112-115. PMID 12758199 DOI: 10.1016/S1472-9792(02)00069-0  0.52
2003 Taylor JL, Turner OC, Basaraba RJ, Belisle JT, Huygen K, Orme IM. Pulmonary necrosis resulting from DNA vaccination against tuberculosis. Infection and Immunity. 71: 2192-8. PMID 12654841 DOI: 10.1128/Iai.71.4.2192-2198.2003  0.6
2003 Vesosky B, Turner OC, Turner J, Orme IM. Activation marker expression on bovine peripheral blood gammadelta T cells during post-natal development and following vaccination with a commercial polyvalent viral vaccine. Developmental and Comparative Immunology. 27: 439-47. PMID 12631526 DOI: 10.1016/S0145-305X(02)00134-9  0.52
2003 Lenaerts AJ, Gruppo V, Brooks JV, Orme IM. Rapid in vivo screening of experimental drugs for tuberculosis using gamma interferon gene-disrupted mice. Antimicrobial Agents and Chemotherapy. 47: 783-5. PMID 12543692 DOI: 10.1128/AAC.47.2.783-785.2003  0.52
2003 Turner OC, Basaraba RJ, Orme IM. Immunopathogenesis of pulmonary granulomas in the guinea pig after infection with Mycobacterium tuberculosis. Infection and Immunity. 71: 864-71. PMID 12540568 DOI: 10.1128/Iai.71.2.864-871.2003  0.52
2002 González-Juarrero M, Turner J, Basaraba RJ, Belisle JT, Orme IM. Florid pulmonary inflammatory responses in mice vaccinated with Antigen-85 pulsed dendritic cells and challenged by aerosol with Mycobacterium tuberculosis. Cellular Immunology. 220: 13-9. PMID 12718935 DOI: 10.1016/S0008-8749(03)00010-8  0.52
2002 Gruppo V, Orme IM. Dose of BCG does not influence the efficient generation of protective immunity in mice challenged with Mycobacterium tuberculosis Tuberculosis. 82: 267-273. PMID 12623269 DOI: 10.1054/tube.2002.0340  0.52
2002 Turner J, Gonzalez-Juarrero M, Ellis DL, Basaraba RJ, Kipnis A, Orme IM, Cooper AM. In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice. Journal of Immunology (Baltimore, Md. : 1950). 169: 6343-51. PMID 12444141 DOI: 10.4049/Jimmunol.169.11.6343  0.52
2002 Brennan PJ, Terwilliger T, Barry CE, Manca C, Su H, Reed M, Rutter K, Domenech P, Kaplan G, Li YJ, Wagner D, Bermudez LE, Bodnar K, Flynn J, Campos-Neto A, ... ... Orme I, et al. The US-Japan Cooperative Medical Science Program Tuberculosis and Leprosy Panel's 36th annual research conference, New Orleans, Louisiana, USA, 15-17 July 2001 Tuberculosis. 82: 113-135. PMID 12408170 DOI: 10.1054/Tube.2002.0329  0.52
2002 Saunders BM, Frank AA, Orme IM, Cooper AM. CD4 is required for the development of a protective granulomatous response to pulmonary tuberculosis Cellular Immunology. 216: 65-72. PMID 12381351 DOI: 10.1016/S0008-8749(02)00510-5  0.52
2002 Gruppo V, Turner OC, Orme IM, Turner J. Reduced up-regulation of memory and adhesion/integrin molecules in susceptible mice and poor expression of immunity to pulmonary tuberculosis. Microbiology (Reading, England). 148: 2959-66. PMID 12368429 DOI: 10.1099/00221287-148-10-2959  0.52
2002 Turner J, Frank AA, Orme IM. Old mice express a transient early resistance to pulmonary tuberculosis that is mediated by CD8 T cells. Infection and Immunity. 70: 4628-37. PMID 12117976 DOI: 10.1128/Iai.70.8.4628-4637.2002  0.52
2002 Turner J, Orme IM. Identification of altered integrin alpha/beta chain expression on T cells from old mice infected with Mycobacterium tuberculosis. Experimental Gerontology. 37: 907-16. PMID 12086699 DOI: 10.1016/S0531-5565(02)00026-8  0.52
2002 Adams LB, Scollard DM, Ray NA, Cooper AM, Frank AA, Orme IM, Krahenbuhl JL. The study of Mycobacterium leprae infection in interferon-γ gene-disrupted mice as a model to explore the immunopathologic spectrum of leprosy Journal of Infectious Diseases. 185. PMID 11865434 DOI: 10.1086/338002  0.52
2002 Cooper AM, Kipnis A, Turner J, Magram J, Ferrante J, Orme IM. Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. Journal of Immunology (Baltimore, Md. : 1950). 168: 1322-7. PMID 11801672 DOI: 10.4049/Jimmunol.168.3.1322  0.52
2002 Roberts AD, Cooper AM, Belisle JT, Turner J, Gonzalez-Juarerro M, Orme IM. Murine model of tuberculosis Methods in Microbiology. 32: 433-462. DOI: 10.1016/S0580-9517(02)32101-9  0.52
2001 Turner OC, Sugawara, Yamada H, Cummings B, Orme IM. Crystalloid inclusions in the cytoplasm of alveolar macrophages of the SwR/J mouse. A possible cause of susceptibility to mycobacterium tuberculosis? Journal of Submicroscopic Cytology and Pathology. 33: 217-9. PMID 11686404  0.52
2001 Covert BA, Spencer JS, Orme IM, Belisle JT. The application of proteomics in defining the T cell antigens of Mycobacterium tuberculosis Proteomics. 1: 574-586. PMID 11681210 DOI: 10.1002/1615-9861(200104)1:4<574::Aid-Prot574>3.0.Co;2-8  0.52
2001 Pearl JE, Saunders B, Ehlers S, Orme IM, Cooper AM. Inflammation and lymphocyte activation during mycobacterial infection in the interferon-γ-deficient mouse Cellular Immunology. 211: 43-50. PMID 11585387 DOI: 10.1006/cimm.2001.1819  0.52
2001 Orme IM. The latent tuberculosis bacillus (I'll let you know if I ever meet one) International Journal of Tuberculosis and Lung Disease. 5: 589-593. PMID 11469255  0.52
2001 Orme IM. Immunology and vaccinology of tuberculosis: Can lessons from the mouse be applied to the cow? Tuberculosis. 81: 109-113. PMID 11463231 DOI: 10.1054/tube.2000.0257  0.52
2001 Orme IM. The search for new vaccines against tuberculosis Journal of Leukocyte Biology. 70: 1-10. PMID 11435479  0.52
2001 Orme I. Search for new drugs for treatment of tuberculosis Antimicrobial Agents and Chemotherapy. 45: 1943-1946. PMID 11408205 DOI: 10.1128/AAC.45.7.1943-1946.2001  0.52
2001 Turner J, Gonzalez-Juarrero M, Saunders BM, Brooks JV, Marietta P, Ellis DL, Frank AA, Cooper AM, Orme IM. Immunological basis for reactivation of tuberculosis in mice. Infection and Immunity. 69: 3264-70. PMID 11292749 DOI: 10.1128/Iai.69.5.3264-3270.2001  0.52
2001 Turner J, Frank AA, Brooks JV, Marietta PM, Orme IM. Pentoxifylline treatment of mice with chronic pulmonary tuberculosis accelerates the development of destructive pathology. Immunology. 102: 248-53. PMID 11260331 DOI: 10.1046/J.1365-2567.2001.01161.X  0.52
2001 Brooks JV, Frank AA, Keen MA, Bellisle JT, Orme IM. Boosting vaccine for tuberculosis. Infection and Immunity. 69: 2714-7. PMID 11254639 DOI: 10.1128/IAI.69.4.2714-2717.2001  0.52
2001 Turner J, Frank AA, Brooks JV, Gonzalez-Juarrero M, Orme IM. The progression of chronic tuberculosis in the mouse does not require the participation of B lymphocytes or interleukin-4. Experimental Gerontology. 36: 537-45. PMID 11250124 DOI: 10.1016/S0531-5565(00)00257-6  0.52
2001 Orme IM, McMurray DN, Belisle JT. Tuberculosis vaccine development: Recent progress Trends in Microbiology. 9: 115-118. PMID 11239788 DOI: 10.1016/S0966-842X(00)01949-1  0.52
2001 Turner J, Frank AA, Brooks JV, Marietta PM, Vesosky B, Orme IM. Tuberculosis in aged gammadelta T cell gene disrupted mice. Experimental Gerontology. 36: 245-54. PMID 11226740 DOI: 10.1016/S0531-5565(00)00199-6  0.52
2001 Gonzalez-Juarrero M, Turner OC, Turner J, Marietta P, Brooks JV, Orme IM. Temporal and spatial arrangement of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis. Infection and Immunity. 69: 1722-8. PMID 11179349 DOI: 10.1128/Iai.69.3.1722-1728.2001  0.52
2001 Gonzalez-Juarrero M, Orme IM. Characterization of murine lung dendritic cells infected with Mycobacterium tuberculosis Infection and Immunity. 69: 1127-1133. PMID 11160010 DOI: 10.1128/Iai.69.2.1127-1133.2001  0.52
2001 Turner J, D'Souza CD, Pearl JE, Marietta P, Noel M, Frank AA, Appelberg R, Orme IM, Cooper AM. CD8- and CD95/95L-dependent mechanisms of resistance in mice with chronic pulmonary tuberculosis. American Journal of Respiratory Cell and Molecular Biology. 24: 203-9. PMID 11159055 DOI: 10.1165/Ajrcmb.24.2.4370  0.52
2000 Pearl JE, Orme IM, Cooper AM. CD95 signaling is not required for the down regulation of cellular responses to systemic Mycobacterium tuberculosis infection Tubercle and Lung Disease. 80: 273-279. PMID 11162768 DOI: 10.1054/tuld.2000.0274  0.52
2000 Skeiky YAW, Ovendale PJ, Jen S, Alderson MR, Dillon DC, Smith S, Wilson CB, Orme IM, Reed SG, Campos-Neto A. T cell expression cloning of a Mycobacterium tuberculosis gene encoding a protective antigen associated with the early control of infection Journal of Immunology. 165: 7140-7149. PMID 11120845 DOI: 10.4049/jimmunol.165.12.7140  0.52
2000 Cooper AM, Pearl JE, Brooks JV, Ehlers S, Orme IM. Expression of the nitric oxide synthase 2 gene is not essential for early control of Mycobacterium tuberculosis in the murine lung. Infection and Immunity. 68: 6879-82. PMID 11083808 DOI: 10.1128/IAI.68.12.6879-6882.2000  0.52
2000 Siddiqui SM, Orme IM, Saxena RK. Efficacy of culture filtrate protein preparations from Indian isolates of M. tuberculosis to activate T cells derived from healthy donors International Journal of Tuberculosis and Lung Disease. 4: 980-987. PMID 11055767  0.52
2000 D'Souza CD, Cooper AM, Frank AA, Ehlers S, Turner J, Bendelac A, Orme IM. A novel nonclassic β2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung American Journal of Respiratory Cell and Molecular Biology. 23: 188-193. PMID 10919985 DOI: 10.1165/Ajrcmb.23.2.4063  0.52
2000 Dow SW, Roberts A, Vyas J, Rodgers J, Rich RR, Orme I, Potter TA. Immunization with f-Met peptides induces immune reactivity against Mycobacterium tuberculosis Tubercle and Lung Disease. 80: 5-13. PMID 10897379 DOI: 10.1054/tuld.1999.0226  0.52
2000 Turner OC, Roberts AD, Frank AA, Phalen SW, McMurray DM, Content J, Denis O, D'Souza S, Tanghe A, Huygen K, Orme IM. Lack of protection in mice and necrotizing bronchointerstitial pneumonia with bronchiolitis in guinea pigs immunized with vaccines directed against the hsp60 molecule of Mycobacterium tuberculosis Infection and Immunity. 68: 3674-3679. PMID 10816527 DOI: 10.1128/Iai.68.6.3674-3679.2000  0.52
2000 Saunders BM, Frank AA, Orme IM, Cooper AM. Interleukin-6 induces early gamma interferon production in the infected lung but is not required for generation of specific immunity to Mycobacterium tuberculosis infection Infection and Immunity. 68: 3322-3326. PMID 10816480 DOI: 10.1128/IAI.68.6.3322-3326.2000  0.52
2000 Orme IM. Tuberculosis: recent progress in basic immunity and vaccine development Kekkaku. 75: 97-101. PMID 10723942  0.52
2000 Turner J, Rhoades ER, Keen M, Belisle JT, Frank AA, Orme IM. Effective preexposure tuberculosis vaccines fail to protect when they are given in an immunotherapeutic mode. Infection and Immunity. 68: 1706-9. PMID 10678993 DOI: 10.1128/Iai.68.3.1706-1709.2000  0.52
2000 Cooper AM, Segal BH, Frank AA, Holland SM, Orme IM. Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice. Infection and Immunity. 68: 1231-4. PMID 10678931 DOI: 10.1128/IAI.68.3.1231-1234.2000  0.52
2000 Pedrosa J, Saunders BM, Appelberg R, Orme IM, Silva MT, Cooper AM. Neutrophils play a protective nonphagocytic role in systemic Mycobacterium tuberculosis infection of mice Infection and Immunity. 68: 577-583. PMID 10639420 DOI: 10.1128/IAI.68.2.577-583.2000  0.52
1999 Orme IM. Virulence of recent notorious mycobacterium tuberculosis isolates Tubercle and Lung Disease. 79: 379-381. PMID 10694983 DOI: 10.1054/tuld.1999.0221  0.52
1999 Baldwin SL, D'Souza CD, Orme IM, Liu MA, Huygen K, Denis O, Tang A, Zhu L, Montgomery D, Ulmer JB. Immunogenicity and protective efficacy of DNA vaccines encoding secreted and non-secreted forms of Mycobacterium tuberculosis Ag85A Tubercle and Lung Disease. 79: 251-259. PMID 10692994 DOI: 10.1054/tuld.1998.0196  0.52
1999 Orme IM, Murray PJ. Towards controlling mycobacterial infections [2] (multiple letters) Trends in Microbiology. 7: 478-479. PMID 10603480 DOI: 10.1016/S0966-842X(99)01612-1  0.52
1999 Saunders BM, Frank AA, Orme IM. Granuloma formation is required to contain bacillus growth and delay mortality in mice chronically infected with Mycobacterium tuberculosis Immunology. 98: 324-328. PMID 10583589 DOI: 10.1046/j.1365-2567.1999.00877.x  0.52
1999 Ehlers S, Kutsch S, Benini J, Cooper A, Hahn C, Gerdes J, Orme I, Martin C, Rietschel ET. NOS2-derived nitric oxide regulates the size, quantity and quality of granuloma formation in Mycobacterium avium-infected mice without affecting bacterial loads Immunology. 98: 313-323. PMID 10583588 DOI: 10.1046/j.1365-2567.1999.00875.x  0.52
1999 Orme IM. Beyond BCG: The potential for a more effective TB vaccine Molecular Medicine Today. 5: 487-492. PMID 10529790 DOI: 10.1016/S1357-4310(99)01594-4  0.52
1999 Orme IM, Belisle JT. TB vaccine development: After the flood Trends in Microbiology. 7: 394-395. PMID 10498945 DOI: 10.1016/S0966-842X(99)01591-7  0.52
1999 Moran AJ, Doran JL, Wu J, Treit JD, Ekpo P, Kerr VJ, Roberts AD, Orme IM, Galant S, Ress SR, Nano FE. Identification of novel immunogenic Mycobacterium tuberculosis peptides that stimulate mononuclear cells from immune donors Fems Microbiology Letters. 177: 123-130. PMID 10436930 DOI: 10.1111/J.1574-6968.1999.Tb13722.X  0.52
1999 Kirman J, McCoy K, Hook S, Prout M, Delahunt B, Orme I, Frank A, Le Gros G. CTLA-4 blockade enhances the immune response induced by mycobacterial infection but does not lead to increased protection Infection and Immunity. 67: 3786-3792. PMID 10417139 DOI: 10.1128/Iai.67.8.3786-3792.1999  0.52
1999 Orme IM, Cooper AM. Cytokine/chemokine cascades in immunity to tuberculosis Immunology Today. 20: 307-312. PMID 10379048 DOI: 10.1016/S0167-5699(98)01438-8  0.52
1999 Dillon DC, Alderson MR, Day CH, Lewinsohn DM, Coler R, Bement T, Campos-Neto A, Skeiky YAW, Orme IM, Roberts A, Steen S, Dalemans W, Badaro R, Reed SG. Molecular characterization and human T-cell responses to a member of a novel Mycobacterium tuberculosis mtb39 gene family Infection and Immunity. 67: 2941-2950. PMID 10338503 DOI: 10.1128/iai.67.6.2941-2950.1999  0.52
1999 Brooks JV, Furney SK, Orme IM. Metronidazole therapy in mice infected with tuberculosis. Antimicrobial Agents and Chemotherapy. 43: 1285-8. PMID 10223954  0.52
1999 Cardona PJ, Cooper A, Luquín M, Ariza A, Filipo F, Orme IM, Ausina V. The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity Scandinavian Journal of Immunology. 49: 362-366. PMID 10219760 DOI: 10.1046/j.1365-3083.1999.00522.x  0.52
1999 Orme IM. New vaccines against tuberculosis. The status of current research Infectious Disease Clinics of North America. 13: 169-185. PMID 10198798 DOI: 10.1016/S0891-5520(05)70049-0  0.52
1999 Orme IM. Vaccination against tuberculosis: Recent progress Advances in Veterinary Medicine. 41: 135-143. PMID 9890014 DOI: 10.1016/S0065-3519(99)80013-5  0.52
1998 Ulmer JB, Montgomery DL, Tang A, Zhu L, Deck RR, DeWitt C, Denis O, Orme I, Content J, Huygen K. DNA vaccines against tuberculosis. Novartis Foundation Symposium. 217: 239-46; discussion 2. PMID 9949812  0.52
1998 Orme I. Cellular and genetic mechanisms underlying susceptibility of animal models to tuberculosis infection Novartis Foundation Symposium. 112-119. PMID 9949804 DOI: 10.1002/0470846526.Ch8  0.52
1998 Orme IM, Roberts AD. Changes in integrin/adhesion molecule expression, but not in the T-cell receptor repertoire, in old mice infected with tuberculosis Mechanisms of Ageing and Development. 105: 19-29. PMID 9922116 DOI: 10.1016/S0047-6374(98)00079-7  0.52
1998 Rhoades ER, Orme IM. Similar responses by macrophages from young and old mice infected with Mycobacterium tuberculosis. Mechanisms of Ageing and Development. 106: 145-53. PMID 9883979 DOI: 10.1016/S0047-6374(98)00113-4  0.52
1998 Brooks JV, Orme IM. Evaluation of once-weekly therapy for tuberculosis using isoniazid plus rifamycins in the mouse aerosol infection model. Antimicrobial Agents and Chemotherapy. 42: 3047-8. PMID 9797254  0.52
1998 Saunders BM, Frank AA, Cooper AM, Orme IM. Role of T cells in immunopathology of pulmonary Mycobacterium avium infection in mice Infection and Immunity. 66: 5508-5514. PMID 9784564  0.52
1998 Bosio CM, Orme IM. Effective, nonsensitizing vaccination with culture filtrate proteins against virulent Mycobacterium bovis infections in mice. Infection and Immunity. 66: 5048-51. PMID 9746617  0.52
1998 Roberts AD, Orme IM. CD95 expression in aged mice infected with tuberculosis Infection and Immunity. 66: 5036-5040. PMID 9746615  0.52
1998 Cooper AM, Appelberg R, Orme IM. Immunopathogenesis of Mycobacterium avium infection Frontiers in Bioscience : a Journal and Virtual Library. 3. PMID 9693155  0.52
1998 Orme IM. The immunopathogenesis of tuberculosis: a new working hypothesis Trends in Microbiology. 6: 94-97. PMID 9582931  0.52
1998 DiTirro J, Rhoades ER, Roberts AD, Burke JM, Mukasa A, Cooper AM, Frank AA, Born WK, Orme IM. Disruption of the cellular inflammatory response to Listeria monocytogenes infection in mice with disruptions in targeted genes. Infection and Immunity. 66: 2284-9. PMID 9573119 DOI: 10.1128/iai.66.5.2284-2289.1998  0.52
1998 Johnson CM, Cooper AM, Frank AA, Orme IM. Adequate Expression of Protective Immunity in the Absence of Granuloma Formation in Mycobacterium tuberculosis-Infected Mice with a Disruption in the Intracellular Adhesion Molecule 1 Gene Infection and Immunity. 66: 1666-1670. PMID 9529096  0.52
1998 Valway SE, Sanchez MP, Shinnick TF, Orme I, Agerton T, Hoy D, Jones JS, Westmoreland H, Onorato IM. An outbreak involving extensive transmission of a virulent strain of Mycobacterium tuberculosis. The New England Journal of Medicine. 338: 633-9. PMID 9486991 DOI: 10.1056/NEJM199803053381001  0.52
1998 Roberts AD, Belisle JT, Cooper AM, Orme IM. 4 Specific Models. 4.1 Murine Model of Tuberculosis Methods in Microbiology. 25: 389-417. DOI: 10.1016/S0580-9517(08)70687-1  0.52
1997 Johnson CM, Cooper AM, Frank AA, Bonorino CBC, Wysoki LJ, Orme IM. Mycobacterium tuberculosis aerogenic rechallenge infections in B cell-deficient mice Tubercle and Lung Disease. 78: 257-261. PMID 10209680 DOI: 10.1016/S0962-8479(97)90006-X  0.52
1997 Cooper AM, Callahan JE, Keen M, Belisle JT, Orme IM. Expression of memory immunity in the lung following re-exposure to Mycobacterium tuberculosis. Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease. 78: 67-73. PMID 9666964 DOI: 10.1016/S0962-8479(97)90017-4  0.52
1997 Orme IM. Progress in the development of new vaccines against tuberculosis International Journal of Tuberculosis and Lung Disease. 1: 95-100. PMID 9441089  0.52
1997 Cooper AM, Magram J, Ferrante J, Orme IM. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis Journal of Experimental Medicine. 186: 39-45. PMID 9206995 DOI: 10.1084/jem.186.1.39  0.52
1997 Florido M, Appelberg R, Orme IM, Cooper AM. Evidence for a reduced chemokine response in the lungs of beige mice infected with Mycobacterium avium Immunology. 90: 600-606. PMID 9176115  0.52
1997 Abou-Zeid C, Gares MP, Inwald J, Janssen R, Zhang Y, Young DB, Hetzel C, Lamb JR, Baldwin SL, Orme IM, Yeremeev V, Nikonenko BV, Apt AS. Induction of a type 1 immune response to a recombinant antigen from Mycobacterium tuberculosis expressed in Mycobacterium vaccae Infection and Immunity. 65: 1856-1862. PMID 9125572 DOI: 10.1128/iai.65.5.1856-1862.1997  0.52
1997 Cooper AM, D'Souza C, Frank AA, Orme IM. The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin- or granzyme-mediated cytolytic mechanisms Infection and Immunity. 65: 1317-1320. PMID 9119468  0.52
1997 Cooper AM, Saunders BM, D'Souza CD, Frank AA, Orme IM. Mycobacterium tuberculosis-driven processes in gene-disrupted mice Bulletin De L'Institut Pasteur. 95: 85-96. DOI: 10.1016/S0020-2452(97)83916-4  0.52
1997 Valway S, Sanchez M, Shinnick T, Orme I, Agerton T, Onorato I. Extensive transmission of Mycobacterium tuberculosis due to increased virulence Clinical Infectious Diseases. 25: 361.  0.52
1996 Slayden RA, Lee RE, Armour JW, Cooper AM, Orme IM, Brennan PJ, Besra GS. Antimycobacterial action of thiolactomycin: An inhibitor of fatty acid and mycolic acid synthesis Antimicrobial Agents and Chemotherapy. 40: 2813-2819. PMID 9124847 DOI: 10.1128/Aac.40.12.2813  0.52
1996 Kelly BP, Furney SK, Jessen MT, Orme IM. Low-dose aerosol infection model for testing drugs for efficacy against Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 40: 2809-12. PMID 9124846  0.52
1996 Orme IM. Immune responses in animal models Current Topics in Microbiology and Immunology. 215: 181-196. PMID 8791714  0.52
1995 Orme IM. Prospects for new vaccines against tuberculosis Trends in Microbiology. 3: 401-404. PMID 8564360 DOI: 10.2144/02335Dd01  0.52
1995 Ordway DJ, Sonnenberg MG, Donahue SA, Belisle JT, Orme IM. Drug-resistant strains of Mycobacterium tuberculosis exhibit a range of virulence for mice Infection and Immunity. 63: 741-743. PMID 7822053 DOI: 10.1128/Iai.63.2.741-743.1995  0.52
1995 Hanson MS, Bansal GP, Langermann S, Stover CK, Orme I. Efficacy and safety of live recombinant BCG vaccines Developments in Biological Standardization. 84: 229-236. PMID 7796958  0.52
1995 Furney SK, Skinner PS, Farrer J, Orme IM. Activities of rifabutin, clarithromycin, and ethambutol against two virulent strains of Mycobacterium avium in a mouse model. Antimicrobial Agents and Chemotherapy. 39: 786-9. PMID 7793895  0.52
1995 Skinner PS, Furney SK, Kleinert DA, Orme IM. Comparison of activities of fluoroquinolones in murine macrophages infected with Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 39: 750-3. PMID 7793885  0.52
1995 Orme I, Weksler ME, Goodwin JS, Lesourd B, Keusch G, Makinodan T, Kelley KW, Bendich A, Meydani SN, Ernst DN. Mechanisms underlying the increased susceptibility of aged mice to tuberculosis Nutrition Reviews. 53: S35-S40. PMID 7644152 DOI: 10.1111/J.1753-4887.1995.Tb01514.X  0.52
1995 Ernst DN, Weigle O, Hobbs MV, Miller RA, Weksler ME, Orme I, Kelley KW. Aging and lymphokine gene expression by T cell subsets Nutrition Reviews. 53: S18-S26. PMID 7644149  0.52
1995 Cooper AM, Callahan JE, Griffin JP, Roberts AD, Orme IM. Old mice are able to control low-dose aerogenic infections with Mycobacterium tuberculosis Infection and Immunity. 63: 3259-3265. PMID 7642254  0.52
1995 Rhoades ER, Cooper AM, Orme IM. Chemokine response in mice infected with Mycobacterium tuberculosis Infection and Immunity. 63: 3871-3877. PMID 7558294  0.52
1994 Xu S, Cooper A, Sturgill-Koszycki S, Van Heyningen T, Chatterjee D, Orme I, Allen P, Russell DG. Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages Journal of Immunology. 153: 2568-2578. PMID 8077667  0.52
1994 Appelberg R, Castro AG, Pedrosa J, Silva RA, Orme IM, Minoprio P. Role of gamma interferon and tumor necrosis factor alpha during T-cell- independent and -dependent phases of Mycobacterium avium infection Infection and Immunity. 62: 3962-3971. PMID 8063414  0.52
1994 Skinner PS, Furney SK, Jacobs MR, Klopman G, Ellner JJ, Orme IM. A bone marrow-derived murine macrophage model for evaluating efficacy of antimycobacterial drugs under relevant physiological conditions. Antimicrobial Agents and Chemotherapy. 38: 2557-63. PMID 7872747 DOI: 10.1128/Aac.38.11.2557  0.52
1994 Orme I. Protective and memory immunity in mice infected with mycobacterium tuberculosis Immunobiology. 191: 503-508. PMID 7713564 DOI: 10.1016/S0171-2985(11)80456-0  0.52
1994 Orme IM, Roberts AD, Furney SK, Skinner PS. Animal and cell-culture models for the study of mycobacterial infections and treatment. European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology. 13: 994-9. PMID 7698125 DOI: 10.1007/BF02111500  0.52
1994 Griffin JP, Orme IM. Evolution of CD4 T-cell subsets following infection of naive and memory immune mice with Mycobacterium tuberculosis Infection and Immunity. 62: 1683-1690. PMID 7513305  0.52
1993 Roberts AD, Ordway DJ, Orme IM. Listeria monocytogenes infection in β2 microglobulin-deficient mice Infection and Immunity. 61: 1113-1116. PMID 8432593 DOI: 10.1128/iai.61.3.1113-1116.1993  0.52
1993 Orme IM, Furney SK, Skinner PS, Roberts AD, Brennan PJ, Russell DG, Shiratsuchi H, Ellner JJ, Weiser WY. Inhibition of growth of Mycobacterium avium in murine and human mononuclear phagocytes by migration inhibitory factor. Infection and Immunity. 61: 338-42. PMID 8418058 DOI: 10.1128/Iai.61.1.338-342.1993  0.52
1993 Appelberg R, Orme IM. Effector mechanisms involved in cytokine-mediated bacteriostasis of Mycobacterium avium infections in murine macrophages Immunology. 80: 352-359. PMID 8288311  0.52
1993 Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme IM. Disseminated tuberculosis in interferon γ gene-disrupted mice Journal of Experimental Medicine. 178: 2243-2247. PMID 8245795 DOI: 10.1084/Jem.178.6.2243  0.52
1993 Orme IM. Immunity to mycobacteria Current Opinion in Immunology. 5: 497-502. PMID 8216924 DOI: 10.1016/0952-7915(93)90029-R  0.52
1993 Orme IM. The role of CD8+ T cells in immunity to tuberculosis infection Trends in Microbiology. 1: 77-78. PMID 8143120 DOI: 10.1016/0966-842X(93)90109-5  0.52
1993 Orme IM, Roberts AD, Griffin JP, Abrams JS. Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection Journal of Immunology. 151: 518-525. PMID 8100846  0.52
1993 Orme IM, Griffin JP, Roberts AD, Ernst DN. Evidence for a defective accumulation of protective T cells in old mice infected with Mycobacterium tuberculosis Cellular Immunology. 147: 222-229. PMID 7681730 DOI: 10.1006/cimm.1993.1062  0.52
1992 Chatterjee D, Roberts AD, Lowell K, Brennan PJ, Orme IM. Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor Infection and Immunity. 60: 1249-1253. PMID 1541542 DOI: 10.1128/Iai.60.3.1249-1253.1992  0.52
1992 Orme IM, Chatterjee D. Antibody levels to the type-specific glycopeptidolipid antigens of Mycobacterium avium in homosexual men: possible implications Research in Microbiology. 143: 381-385. PMID 1455065 DOI: 10.1016/0923-2508(92)90050-X  0.52
1992 Furney SK, Skinner PS, Roberts AD, Appelberg R, Orme IM. Capacity of Mycobacterium avium isolates to grow well or poorly in murine macrophages resides in their ability to induce secretion of tumor necrosis factor. Infection and Immunity. 60: 4410-3. PMID 1398951  0.52
1992 Orme IM, Furney SK, Roberts AD. Dissemination of enteric Mycobacterium avium infections in mice rendered immunodeficient by thymectomy and CD4 depletion or by prior infection with murine AIDS retroviruses. Infection and Immunity. 60: 4747-53. PMID 1356931  0.52
1992 Appelberg R, Orme IM, Pinto De Sousa MI, Silva MT. In vitro effects of interleukin-4 on interferon-γ-induced macrophage activation Immunology. 76: 553-559. PMID 1328038  0.52
1991 Orme I. Processing and presentation of mycobacterial antigens: implications for the development of a new improved vaccine for tuberculosis control Tubercle. 72: 250-252. PMID 1839811 DOI: 10.1016/0041-3879(91)90048-W  0.52
1991 Griffin JP, Harshan KV, Born WK, Orme IM. Kinetics of accumulation of gamma delta receptor-bearing T lymphocytes in mice infected with live mycobacteria. Infection and Immunity. 59: 4263-5. PMID 1834574  0.52
1991 Orme IM. The molecular targets of T cells in acquired immunity to tuberculosis Immunology Letters. 30: 207-211. PMID 1684572 DOI: 10.1016/0165-2478(91)90027-8  0.52
1990 Trust KA, Miller MW, Ringelman JK, Orme IM. Effects of ingested lead on antibody production in mallards (Anas platyrhynchos) Journal of Wildlife Diseases. 26: 316-322. PMID 2388354  0.52
1990 Furney SK, Roberts AD, Orme IM. Effect of rifabutin on disseminated Mycobacterium avium infections in thymectomized, CD4 T-cell-deficient mice. Antimicrobial Agents and Chemotherapy. 34: 1629-32. PMID 2178333  0.52
1989 Miller ES, Orme IM. Patterns of IL-2 production and utilization in mice heavily infected with Mycobacterium bovis BCG reflect the phase of protective immunity being expressed Immunology. 67: 221-224. PMID 2666309  0.52
1989 Orme IM. Aging and immunity to tuberculosis: Prolonged survival of old mice infected with Mycobacterium tuberculosis by adoptive immunization with memory-immune T lymphocytes Cellular Immunology. 118: 229-233. PMID 2521305 DOI: 10.1016/0008-8749(89)90372-9  0.52
1989 Orme IM. Active and memory immunity to Listeria monocytogenes infection in mice is mediated by phenotypically distinct T-cell populations Immunology. 68: 93-95. PMID 2509327  0.52
1988 Orme IM. A mouse model of the recrudescence of latent tuberculosis in the elderly American Review of Respiratory Disease. 137: 716-718. PMID 3345049  0.52
1988 Orme IM. The immune response to the cell wall of Mycobacterium bovis BCG Clinical and Experimental Immunology. 71: 388-393. PMID 3289800  0.52
1988 Orme IM. An age-related loss of the isogeneic barrier to the successful passive cell transfer of antimicrobial immunity in mice Mechanisms of Ageing and Development. 46: 29-32. PMID 3265750 DOI: 10.1016/0047-6374(88)90111-X  0.52
1988 Orme IM. Evidence for a biphasic memory T-cell response to high dose BCG vaccination in mice Tubercle. 69: 125-131. PMID 3263722 DOI: 10.1016/0041-3879(88)90075-X  0.52
1988 Cummins TJ, Orme IM, Smith RE. Reduced in vivo nonspecific resistance to Listeria monocytogenes infection during avian retrovirus-induced immunosuppression Avian Diseases. 32: 663-667. PMID 3202762  0.52
1988 Orme IM. Induction of nonspecific acquired resistance and delayed-type hypersensitivity, but not specific acquired resistance, in mice inoculated with killed mycobacterial vaccines Infection and Immunity. 56: 3310-3312. PMID 3141288  0.52
1988 Orme IM. Characteristics and specificity of acquired immunologic memory to Mycobacterium tuberculosis infection Journal of Immunology. 140: 3589-3593. PMID 3129497  0.52
1988 Orme IM. Antimycobacterial activity in vivo of LM427 (rifabutin) American Review of Respiratory Disease. 138: 1254-1257. PMID 2849349  0.52
1987 Orme IM. Future research in tuberculosis American Review of Respiratory Disease. 136: 525. PMID 3619215  0.52
1987 Roberts EC, Demartini JC, Orme IM. Passive transfer of acquired resistance to Listeria monocytogenes infection is independent of mononuclear cell granuloma formation Infection and Immunity. 55: 3215-3218. PMID 3500132  0.52
1987 Orme IM. Aging and immunity to tuberculosis: Increased susceptibility of old mice reflects a decreased capacity to generate mediator T lymphocytes Journal of Immunology. 138: 4414-4418. PMID 3495592  0.52
1987 Orme IM. The dynamics of infection following bcg and Mycobacterium tuberculosis challenge in t-cell-deficient mice Tubercle. 68: 277-283. PMID 3332058 DOI: 10.1016/0041-3879(87)90068-7  0.52
1987 Orme IM. Immunization of mice with Mycobacterium leprae/Mycobacterium bovis BCG admixtures: Modulation of the acquired response to BCG International Journal of Leprosy. 55: 293-298. PMID 3298475  0.52
1987 Orme IM. The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis Journal of Immunology. 138: 293-298. PMID 3097148  0.52
1987 Orme I. The 65kDa antigen of mycobacteria Immunology Today. 8: 361. DOI: 10.1016/0167-5699(87)90208-8  0.52
1986 Orme IM, Collins FM. Aerogenic vaccination of mice with mycobacterium bovis BCG Tubercle. 67: 133-140. PMID 3775862 DOI: 10.1016/0041-3879(86)90007-3  0.52
1986 Orme IM, Stokes RW, Collins FM. Genetic control of natural resistance to nontuberculous mycobacterial infections in mice. Infection and Immunity. 54: 56-62. PMID 3759239  0.52
1986 Orme IM, Roberts AR, Collins FM. Lack of evidence for a reduction in the efficacy of subcutaneous BCG vaccination in mice infected with nontuberculous mycobacteria Tubercle. 67: 41-46. PMID 3715982 DOI: 10.1016/0041-3879(86)90030-9  0.52
1986 Orme IM, Collins FM. Crossprotection against nontuberculous mycobacterial infections by Mycobacterium tuberculosis memory immune T lymphocytes Journal of Experimental Medicine. 163: 203-208. PMID 3079814  0.52
1986 Stokes RW, Orme IM, Collins FM. Role of mononuclear phagocytes in expression of resistance and susceptibility to Mycobacterium avium infections in mice. Infection and Immunity. 54: 811-9. PMID 3023238  0.52
1985 Orme IM, Collins FM. Prophylactic effect in mice of BCG vaccination against non-tuberculous mycobacterial infections Tubercle. 66: 117-120. PMID 4024269 DOI: 10.1016/0041-3879(85)90076-5  0.52
1984 Orme IM, Collins FM. Immune response to atypical mycobacteria: Immunocompetence of heavily infected mice measured in vivo fails to substantiate immunosuppression data obtained in vitro Infection and Immunity. 43: 32-37. PMID 6690407  0.52
1984 Orme IM, Collins FM. Demonstration of acquired resistance in Bcg(r) inbred mouse strains infected with a low dose of BCG Montreal Clinical and Experimental Immunology. 56: 81-88. PMID 6424988  0.52
1984 Orme IM, Collins FM. Efficacy of Mycobacterium bovis BCG vaccination in mice undergoing prior pulmonary infection with atypical mycobacteria Infection and Immunity. 44: 28-32. PMID 6423543  0.52
1984 Orme IM, Collins FM. Adoptive protection of the Mycobacterium tuberculosis-infected lung. Dissociation between cells that passively transfer protective immunity and those that transfer delayed-type hypersensitivity to tuberculin Cellular Immunology. 84: 113-120. PMID 6421492 DOI: 10.1016/0008-8749(84)90082-0  0.52
1984 Orme IM, Collins FM. Passive transfer of tuberculin sensitivity from anergic mice Infection and Immunity. 46: 850-853. PMID 6389369  0.52
1984 Orme IM, Ratcliffe MJH, Collins FM. Acquired immunity to heavy infection with Mycobacterium bovis Bacillus Calmette-Guérin and its relationship to the development of nonspecific unresponsiveness in vitro Cellular Immunology. 88: 285-296. PMID 6386183 DOI: 10.1016/0008-8749(84)90162-X  0.52
1983 Orme IM, Collins FM. Protection against Mycobacterium tuberculosis infection by adoptive immunotherapy. Requirement for T cell-deficient recipients Journal of Experimental Medicine. 158: 74-83. PMID 6602861  0.52
1983 Orme IM, Collins FM. Resistance of various strains of mycobacteria to killing by activated macrophages in vivo Journal of Immunology. 131: 1452-1454. PMID 6411817  0.52
1983 Orme IM, Collins FM. Infection with Mycobacterium kansasii and efficacy of vaccination against tuberculosis Immunology. 50: 581-586. PMID 6228515  0.52
1982 Orme IM, Shand FL. Concanavalin A-induced alteration of surface marker expression on murine T cells International Journal of Immunopharmacology. 4: 137-142. PMID 6980849 DOI: 10.1016/0192-0561(82)90041-8  0.52
1981 Orme IM, Shand FL. Inhibitors of prostaglandin synthetase block the generation of suppressor T cells induced by concanavalin A International Journal of Immunopharmacology. 3: 15-19. PMID 6457810 DOI: 10.1016/0192-0561(81)90041-2  0.52
1980 Shand FL, Orme IM, Ivanyi J. The induction of suppressor T cells by concanavalin A is independent of cellular proliferation and protein synthesis Scandinavian Journal of Immunology. 12: 223-231. PMID 6451026  0.52
1975 Kuo KN, Lloyd Roberts GC, Orme IM, Soothill JF. Immunodeficiency and infantile bone and joint infection Archives of Disease in Childhood. 50: 51-56. PMID 804866  0.52
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