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David Sinclair - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Genetics, Molecular Biology, Microbiology Biology
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81 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, ... ... Sinclair DA, et al. Loss of epigenetic information as a cause of mammalian aging. Cell. 187: 1312-1313. PMID 38428398 DOI: 10.1016/j.cell.2024.01.049  0.613
2024 Griffin PT, Kane AE, Trapp A, Li J, Arnold M, Poganik JR, Conway RJ, McNamara MS, Meer MV, Hoffman N, Amorim JA, Tian X, MacArthur MR, Mitchell SJ, Mueller AL, ... ... Sinclair DA, et al. TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction. Nature Aging. PMID 38200273 DOI: 10.1038/s43587-023-00555-2  0.471
2023 Guarente L, Sinclair DA, Kroemer G. Human trials exploring anti-aging medicines. Cell Metabolism. PMID 38181790 DOI: 10.1016/j.cmet.2023.12.007  0.469
2023 Lu YR, Tian X, Sinclair DA. The Information Theory of Aging. Nature Aging. 3: 1486-1499. PMID 38102202 DOI: 10.1038/s43587-023-00527-6  0.514
2023 Tian X, Sinclair DA. Restricting mealtime ameliorates neurodegeneration. Cell Metabolism. 35: 1673-1674. PMID 37793341 DOI: 10.1016/j.cmet.2023.09.006  0.439
2023 Yang JH, Petty CA, Dixon-McDougall T, Lopez MV, Tyshkovskiy A, Maybury-Lewis S, Tian X, Ibrahim N, Chen Z, Griffin PT, Arnold M, Li J, Martinez OA, Behn A, Rogers-Hammond R, ... ... Sinclair DA, et al. Chemically induced reprogramming to reverse cellular aging. Aging. 15. PMID 37437248 DOI: 10.18632/aging.204896  0.547
2023 Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, ... ... Sinclair DA, et al. Loss of epigenetic information as a cause of mammalian aging. Cell. PMID 36638792 DOI: 10.1016/j.cell.2022.12.027  0.713
2022 Amorim JA, Coppotelli G, Rolo AP, Palmeira CM, Ross JM, Sinclair DA. Mitochondrial and metabolic dysfunction in ageing and age-related diseases. Nature Reviews. Endocrinology. PMID 35145250 DOI: 10.1038/s41574-021-00626-7  0.541
2022 Meron E, Thaysen M, Angeli S, Antebi A, Barzilai N, Baur JA, Bekker-Jensen S, Birkisdottir M, Bischof E, Bruening J, Brunet A, Buchwalter A, Cabreiro F, Cai S, Chen BH, ... ... Sinclair DA, et al. Meeting Report: Aging Research and Drug Discovery. Aging. 14. PMID 35089871 DOI: 10.18632/aging.203859  0.505
2020 Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, ... ... Sinclair DA, et al. ARDD 2020: from aging mechanisms to interventions. Aging. 12. PMID 33378272 DOI: 10.18632/aging.202454  0.677
2020 Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, ... ... Sinclair DA, et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 588: 124-129. PMID 33268865 DOI: 10.1038/s41586-020-2975-4  0.489
2019 Ross JM, Coppotelli G, Branca RM, Kim KM, Lehtiö J, Sinclair DA, Olson L. Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice. Aging Cell. e13029. PMID 31489782 DOI: 10.1111/Acel.13029  0.59
2019 Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biology. 24: 101192. PMID 31015147 DOI: 10.1016/j.redox.2019.101192  0.339
2019 Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, ... ... Sinclair DA, et al. Impairment of an Endothelial NAD-HS Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 176: 944-945. PMID 30735637 DOI: 10.1016/j.cell.2019.01.026  0.428
2019 Kane A, Schultz MB, Mitchell S, MacArthur M, Mitchell J, Howlett SE, Bonkowski MS, Sinclair D. MACHINE LEARNING ANALYSIS OF MOUSE FRAILTY FOR PREDICTION OF BIOLOGICAL AGE AND LIFE EXPECTANCY Innovation in Aging. 3: S903-S903. DOI: 10.1093/Geroni/Igz038.3299  0.342
2018 Vatner DE, Zhang J, Oydanich M, Guers J, Katsyuba E, Yan L, Sinclair D, Auwerx J, Vatner SF. Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14. Aging Cell. e12751. PMID 29654651 DOI: 10.1111/Acel.12751  0.34
2018 Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, ... ... Sinclair DA, et al. Impairment of an Endothelial NAD-HS Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 173: 74-89.e20. PMID 29570999 DOI: 10.1016/j.cell.2018.02.008  0.48
2018 Griffin P, Yang J, Rajman L, Sinclair D. Investigating The Dna Damage Response As A Driver Of Epigenetic Change During Aging Innovation in Aging. 2: 883-883. DOI: 10.1093/Geroni/Igy031.3296  0.304
2018 Lu Y, Yu D, Bonkowski M, Schultz M, Tian X, Yang J, He Z, Sinclair D. In Vivo Cellular Reprogramming For Tissue Regeneration And Age Reversal Innovation in Aging. 2: 883-883. DOI: 10.1093/Geroni/Igy031.3294  0.301
2018 Amorim J, Tackur S, Bonkowski M, Rolo A, Palmeira C, Sinclair D. A New Mouse Model To Unravel The Mechanism Of Sirt1 Activation Innovation in Aging. 2: 878-878. DOI: 10.1093/Geroni/Igy031.3277  0.397
2018 Bonkowski M, Shawn D, Lu Y, Schultz M, Reyes J, Guarente L, Sinclair D. DIVERGENT REGULATION OF SIRT1 MEDIATES THE ENDOCRINE RESPONSE TO CALORIE RESTRICTION Innovation in Aging. 2: 88-89. DOI: 10.1093/Geroni/Igy023.337  0.304
2018 Schultz MB, Bochaton T, Bonkowski M, Li J, Lokitiyakul D, Colville A, Gomes A, Sinclair D. Nad+ Depletion As A Cause Of Inflammaging Innovation in Aging. 2: 746-746. DOI: 10.1093/Geroni/Igy023.2751  0.362
2018 Ross JM, Coppotelli G, Amorim J, Hillstedt E, Potts E, Sinclair D. DISRUPTING THE EPIGENOME IN NOVEL NICE MICE TO STUDY AGE-RELATED COGNITIVE DECLINE Innovation in Aging. 2: 626-626. DOI: 10.1093/Geroni/Igy023.2333  0.524
2018 Coppotelli G, Ross J, Ling A, Kim K, Sinclair D. CPNE2: A NEW REGULATOR OF LYSOSOMAL-MITOCHONDRIAL FUNCTION INVOLVED IN AGING AND DISEASE Innovation in Aging. 2: 387-388. DOI: 10.1093/Geroni/Igy023.1445  0.566
2018 Ross JM, Coppotelli G, Branca R, Lehtiö J, Sinclair D, Olson L. USING PROTEOMICS TO ELUCIDATE HOW VOLUNTARY EXERCISE COMBATS AGING PHENOTYPES IN MTDNA MUTATOR MICE Innovation in Aging. 2: 334-334. DOI: 10.1093/Geroni/Igy023.1223  0.593
2017 Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. A conserved NAD(+) binding pocket that regulates protein-protein interactions during aging. Science (New York, N.Y.). 355: 1312-1317. PMID 28336669 DOI: 10.1126/Science.Aad8242  0.747
2017 Sinclair D. Nad Precursors As Interventions For Age-Related Diseases And Extending Human Healthspan Innovation in Aging. 1: 11-11. DOI: 10.1093/Geroni/Igx004.037  0.359
2017 Barzilai N, Gorbunova V, Sinclair D. LONG-LIVED ANIMAL MODELS AND HEALTH-SPAN EXTENSION IN STUDIES OF AGING Innovation in Aging. 1: 10-10. DOI: 10.1093/Geroni/Igx004.033  0.548
2016 Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A. JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks. Cell Reports. PMID 27568560 DOI: 10.1016/J.Celrep.2016.08.006  0.734
2016 Dai H, Ellis JL, Sinclair DA, Hubbard BP. Synthesis and Assay of SIRT1-Activating Compounds. Methods in Enzymology. 574: 213-44. PMID 27423864 DOI: 10.1016/Bs.Mie.2016.01.012  0.695
2014 Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK. Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism. Aging Cell. 13: 1075-85. PMID 25257342 DOI: 10.1111/Acel.12273  0.708
2014 Hubbard BP, Sinclair DA. Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends in Pharmacological Sciences. 35: 146-54. PMID 24439680 DOI: 10.1016/J.Tips.2013.12.004  0.701
2014 Sinclair DA, Guarente L. Small-molecule allosteric activators of sirtuins. Annual Review of Pharmacology and Toxicology. 54: 363-80. PMID 24160699 DOI: 10.1146/Annurev-Pharmtox-010611-134657  0.517
2013 Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, ... ... Sinclair DA, et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 155: 1624-38. PMID 24360282 DOI: 10.1016/J.Cell.2013.11.037  0.676
2013 Hubbard BP, Sinclair DA. Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay. Methods in Molecular Biology (Clifton, N.J.). 1077: 167-77. PMID 24014406 DOI: 10.1007/978-1-62703-637-5_11  0.662
2013 Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA. Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism. Cell Cycle (Georgetown, Tex.). 12: 2233-40. PMID 23892437 DOI: 10.4161/Cc.25268  0.791
2013 Biason-Lauber A, Böni-Schnetzler M, Hubbard BP, Bouzakri K, Brunner A, Cavelti-Weder C, Keller C, Meyer-Böni M, Meier DT, Brorsson C, Timper K, Leibowitz G, Patrignani A, Bruggmann R, Boily G, ... ... Sinclair DA, et al. Identification of a SIRT1 mutation in a family with type 1 diabetes. Cell Metabolism. 17: 448-55. PMID 23473037 DOI: 10.1016/J.Cmet.2013.02.001  0.644
2013 Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, ... ... Sinclair DA, et al. Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (New York, N.Y.). 339: 1216-9. PMID 23471411 DOI: 10.1126/Science.1231097  0.783
2013 Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Molecular and Cellular Biology. 33: 1487-502. PMID 23382074 DOI: 10.1128/Mcb.00971-12  0.739
2013 Han J, Hubbard BP, Lee J, Montagna C, Lee HW, Sinclair DA, Suh Y. Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene. Cell Cycle (Georgetown, Tex.). 12: 263-70. PMID 23255128 DOI: 10.4161/Cc.23056  0.69
2013 Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA. Manipulation of a nuclear NAD + salvage pathway delays aging without altering steady-state NAD + levels. Journal of Biological Chemistry. 288: 24160-24160. DOI: 10.1074/jbc.a113.111773  0.77
2012 Sinclair D, Verdin E. The longevity of sirtuins. Cell Reports. 2: 1473-4. PMID 23273894 DOI: 10.1016/J.Celrep.2012.12.004  0.34
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Sinclair DA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.458
2012 Rascón B, Hubbard BP, Sinclair DA, Amdam GV. The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction. Aging. 4: 499-508. PMID 22868943  0.682
2012 Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, ... ... Sinclair DA, et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metabolism. 15: 675-90. PMID 22560220 DOI: 10.1016/J.Cmet.2012.04.003  0.673
2012 Gomes AP, Duarte FV, Nunes P, Hubbard BP, Teodoro JS, Varela AT, Jones JG, Sinclair DA, Palmeira CM, Rolo AP. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. Biochimica Et Biophysica Acta. 1822: 185-95. PMID 22027215 DOI: 10.1016/J.Bbadis.2011.10.008  0.662
2012 Rimmele P, Bigarella CL, d'Escamard V, Izac B, Sinclair D, Ghaffari S. SIRT1 Deacetylase Is Essential for Hematopoietic Stem Cell Activity Via Regulation of Foxo3. Blood. 120: 2315-2315. DOI: 10.1182/Blood.V120.21.2315.2315  0.335
2012 Liu H, Hubbard B, Sinclair D, Ma J, Sturges M, Armstrong L. Abstract 216: Novel assays for Sirtuin and PARP families utilizing unmodified substrates Cancer Research. 72: 216-216. DOI: 10.1158/1538-7445.Am2012-216  0.689
2011 Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, ... ... Sinclair DA, et al. SRT1720 improves survival and healthspan of obese mice. Scientific Reports. 1: 70. PMID 22355589 DOI: 10.1038/Srep00070  0.704
2011 Beirowski B, Gustin J, Armour SM, Yamamoto H, Viader A, North BJ, Michán S, Baloh RH, Golden JP, Schmidt RE, Sinclair DA, Auwerx J, Milbrandt J. Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proceedings of the National Academy of Sciences of the United States of America. 108: E952-61. PMID 21949390 DOI: 10.1073/Pnas.1104969108  0.723
2011 Bernier M, Paul RK, Martin-Montalvo A, Scheibye-Knudsen M, Song S, He HJ, Armour SM, Hubbard BP, Bohr VA, Wang L, Zong Y, Sinclair DA, de Cabo R. Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. The Journal of Biological Chemistry. 286: 19270-9. PMID 21467030 DOI: 10.1074/Jbc.M110.200311  0.789
2011 Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, De Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice Journals of Gerontology - Series a Biological Sciences and Medical Sciences. 66: 191-201. PMID 20974732 DOI: 10.1093/Gerona/Glq178  0.339
2010 Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, ... ... Sinclair DA, et al. Dietary restriction: standing up for sirtuins. Science (New York, N.Y.). 329: 1012-3; author reply. PMID 20798296 DOI: 10.1126/Science.329.5995.1012  0.529
2010 Yang Y, Hubbard BP, Sinclair DA, Tong Q. Characterization of murine SIRT3 transcript variants and corresponding protein products. Journal of Cellular Biochemistry. 111: 1051-8. PMID 20677216 DOI: 10.1002/Jcb.22795  0.643
2010 Sinclair D, Hafner AV, Gomes A, Liang J, Cen Y, Lanza I, Nair S, Sauve A, Rozenzweig A. Does Declining Mitochondrial NAD+ and Unscheduled Opening of Mitochondrial Transition Pore Promote Mammalian Aging? Blood. 116: SCI-3-SCI-3. DOI: 10.1182/Blood.V116.21.Sci-3.Sci-3  0.378
2009 Armour SM, Baur JA, Hsieh SN, Land-Bracha A, Thomas SM, Sinclair DA. Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy. Aging. 1: 515-28. PMID 20157535  0.754
2008 Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. Plos One. 3: e2020. PMID 18414679 DOI: 10.1371/Journal.Pone.0002020  0.465
2007 Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, ... ... Sinclair DA, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 450: 712-6. PMID 18046409 DOI: 10.1038/Nature06261  0.786
2007 Medvedik O, Lamming DW, Kim KD, Sinclair DA. MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. Plos Biology. 5: e261. PMID 17914901 DOI: 10.1371/Journal.Pbio.0050261  0.798
2007 Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell. 130: 1095-107. PMID 17889652 DOI: 10.1016/J.Cell.2007.07.035  0.763
2007 Medvedik O, Sinclair DA. Caloric restriction and life span determination of yeast cells. Methods in Molecular Biology (Clifton, N.J.). 371: 97-109. PMID 17634577 DOI: 10.1007/978-1-59745-361-5_9  0.798
2007 Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. The Embo Journal. 26: 3169-79. PMID 17581637 DOI: 10.1038/Sj.Emboj.7601758  0.743
2006 Yu MC, Lamming DW, Eskin JA, Sinclair DA, Silver PA. The role of protein arginine methylation in the formation of silent chromatin. Genes & Development. 20: 3249-54. PMID 17158743 DOI: 10.1101/Gad.1495206  0.57
2006 Sinclair DA, Lin SJ, Guarente L. Life-span extension in yeast. Science (New York, N.Y.). 312: 195-7; author reply . PMID 16614198 DOI: 10.1126/Science.312.5771.195D  0.523
2006 Sinclair DA, Guarente L. Unlocking the secrets of longevity genes. Scientific American. 294: 48-51, 54-7. PMID 16502611 DOI: 10.1038/SCIENTIFICAMERICAN0306-48  0.396
2006 Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, Lin S, Sinclair DA. Response to Comment on "HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction" Science. 312: 1312-1312. DOI: 10.1126/Science.1124767  0.764
2005 Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, Lin SJ, Sinclair DA. HST2 mediates SIR2-independent life-span extension by calorie restriction. Science (New York, N.Y.). 309: 1861-4. PMID 16051752 DOI: 10.1126/Science.1113611  0.777
2005 Gama V, Yoshida T, Cohen H, Sinclair D, Yokota T, Distelhorst C, Matsuyama S. Poly-Glutamine Induces Bax-Mediated Cell Death by Dissociating Ku70 from Bax through Ku70-Acetylation. Blood. 106: 4299-4299. DOI: 10.1182/Blood.V106.11.4299.4299  0.31
2004 Lamming DW, Wood JG, Sinclair DA. Small molecules that regulate lifespan: evidence for xenohormesis. Molecular Microbiology. 53: 1003-9. PMID 15306006 DOI: 10.1111/J.1365-2958.2004.04209.X  0.595
2004 Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 430: 686-9. PMID 15254550 DOI: 10.1038/Nature02789  0.43
2004 Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, De Cabo R, Sinclair DA. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase Science. 305: 390-392. PMID 15205477 DOI: 10.1126/Science.1099196  0.793
2004 Cohen HY, Lavu S, Bitterman KJ, Hekking B, Imahiyerobo TA, Miller C, Frye R, Ploegh H, Kessler BM, Sinclair DA. Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Molecular Cell. 13: 627-38. PMID 15023334 DOI: 10.1016/S1097-2765(04)00094-2  0.767
2003 Anderson RM, Latorre-Esteves M, Neves AR, Lavu S, Medvedik O, Taylor C, Howitz KT, Santos H, Sinclair DA. Yeast life-span extension by calorie restriction is independent of NAD fluctuation. Science (New York, N.Y.). 302: 2124-6. PMID 14605207 DOI: 10.1126/Science.1088697  0.796
2003 Bitterman KJ, Medvedik O, Sinclair DA. Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiology and Molecular Biology Reviews : Mmbr. 67: 376-99, table of con. PMID 12966141 DOI: 10.1128/Mmbr.67.3.376-399.2003  0.795
2003 Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 425: 191-6. PMID 12939617 DOI: 10.1038/Nature01960  0.799
2003 Sinclair D. Is DNA cut out for a long life? Science of Aging Knowledge Environment : Sage Ke. 2003. PMID 12844521 DOI: 10.1126/Sageke.2003.16.Pe8  0.343
2003 Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature. 423: 181-5. PMID 12736687 DOI: 10.1038/Nature01578  0.789
2002 Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. The Journal of Biological Chemistry. 277: 45099-107. PMID 12297502 DOI: 10.1074/Jbc.M205670200  0.785
2002 Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA. Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. The Journal of Biological Chemistry. 277: 18881-90. PMID 11884393 DOI: 10.1074/Jbc.M111773200  0.791
1999 Ashrafi K, Sinclair D, Gordon JI, Guarente L. Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 96: 9100-5. PMID 10430902 DOI: 10.1073/Pnas.96.16.9100  0.564
1998 Sinclair D, Mills K, Guarente L. Aging in Saccharomyces cerevisiae Annual Review of Microbiology. 52: 533-560. PMID 9891807 DOI: 10.1146/Annurev.Micro.52.1.533  0.576
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