David Sinclair - Publications

Harvard University, Cambridge, MA, United States 
Genetics, Molecular Biology, Microbiology Biology

90 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, ... ... Sinclair DA, et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 588: 124-129. PMID 33268865 DOI: 10.1038/s41586-020-2975-4  0.32
2020 Palliyaguru DL, Minor RK, Mitchell SJ, Palacio HH, Licata JJ, Ward TM, Abulwerdi G, Elliott P, Westphal C, Ellis JL, Sinclair DA, Price NL, Bernier M, de Cabo R. Combining a high dose of metformin with the SIRT1 activator, SRT1720, reduces lifespan in aged mice fed a high-fat diet. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 32556267 DOI: 10.1093/gerona/glaa148  0.44
2019 Ross JM, Coppotelli G, Branca RM, Kim KM, Lehtiö J, Sinclair DA, Olson L. Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice. Aging Cell. e13029. PMID 31489782 DOI: 10.1111/acel.13029  0.48
2018 Dai H, Sinclair DA, Ellis JL, Steegborn C. Sirtuin activators and inhibitors: Promises, achievements, and challenges. Pharmacology & Therapeutics. PMID 29577959 DOI: 10.1016/j.pharmthera.2018.03.004  0.44
2018 Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, ... ... Sinclair DA, et al. Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. Cell Metabolism. 27: 667-676.e4. PMID 29514072 DOI: 10.1016/j.cmet.2018.02.001  0.44
2017 Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. A conserved NAD(+) binding pocket that regulates protein-protein interactions during aging. Science (New York, N.Y.). 355: 1312-1317. PMID 28336669 DOI: 10.1126/science.aad8242  0.56
2016 Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, ... ... Sinclair DA, et al. NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metabolism. 24: 566-581. PMID 27732836 DOI: 10.1016/j.cmet.2016.09.004  0.36
2016 Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A. JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks. Cell Reports. PMID 27568560 DOI: 10.1016/j.celrep.2016.08.006  0.56
2016 Dai H, Ellis JL, Sinclair DA, Hubbard BP. Synthesis and Assay of SIRT1-Activating Compounds. Methods in Enzymology. 574: 213-44. PMID 27423864 DOI: 10.1016/bs.mie.2016.01.012  0.56
2016 Anderson EN, Corkins ME, Li JC, Singh K, Parsons S, Tucey TM, Sorkaç A, Huang H, Dimitriadi M, Sinclair DA, Hart AC. C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins. Mechanisms of Ageing and Development. PMID 26854551 DOI: 10.1016/j.mad.2016.01.004  0.56
2016 Schultz MB, Sinclair DA. When stem cells grow old: phenotypes and mechanisms of stem cell aging. Development (Cambridge, England). 143: 3-14. PMID 26732838 DOI: 10.1242/dev.130633  0.56
2015 Zhang QS, Deater M, Schubert K, Marquez-Loza L, Pelz C, Sinclair DA, Grompe M. The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice. Stem Cell Research. 15: 130-40. PMID 26046330 DOI: 10.1016/j.scr.2015.05.007  0.56
2015 Riepsamen A, Wu L, Lau L, Listijono D, Ledger W, Sinclair DA, Homer H. Correction: Nicotinamide Impairs Entry into and Exit from Meiosis I in Mouse Oocytes. Plos One. 10: e0130058. PMID 26038838 DOI: 10.1371/journal.pone.0130058  0.56
2015 Garg N, Sinclair DA. Oogonial stem cells as a model to study age-associated infertility in women. Reproduction, Fertility, and Development. PMID 25897831 DOI: 10.1071/RD14461  0.56
2015 Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, et al. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nature Communications. 6: 6263. PMID 25672491 DOI: 10.1038/ncomms7263  0.56
2015 Gomes AP, Sinclair DA. Measuring PGC-1α and its acetylation status in mouse primary myotubes. Methods in Molecular Biology (Clifton, N.J.). 1241: 49-57. PMID 25308487 DOI: 10.1007/978-1-4939-1875-1_5  0.56
2015 Miranda MX, van Tits LJ, Lohmann C, Arsiwala T, Winnik S, Tailleux A, Stein S, Gomes AP, Suri V, Ellis JL, Lutz TA, Hottiger MO, Sinclair DA, Auwerx J, Schoonjans K, et al. The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression. European Heart Journal. 36: 51-9. PMID 24603306 DOI: 10.1093/eurheartj/ehu095  0.44
2014 Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK. Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism. Aging Cell. 13: 1075-85. PMID 25257342 DOI: 10.1111/acel.12273  0.56
2014 Rimmelé P, Bigarella CL, Liang R, Izac B, Dieguez-Gonzalez R, Barbet G, Donovan M, Brugnara C, Blander JM, Sinclair DA, Ghaffari S. Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells. Stem Cell Reports. 3: 44-59. PMID 25068121 DOI: 10.1016/j.stemcr.2014.04.015  0.56
2014 Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, ... ... Sinclair DA, et al. SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell. 13: 787-96. PMID 24931715 DOI: 10.1111/acel.12220  0.56
2014 Cronise RJ, Sinclair DA, Bremer AA. The "metabolic winter" hypothesis: a cause of the current epidemics of obesity and cardiometabolic disease. Metabolic Syndrome and Related Disorders. 12: 355-61. PMID 24918620 DOI: 10.1089/met.2014.0027  0.56
2014 Wu LE, Sinclair DA. SIRT2 controls the pentose phosphate switch. The Embo Journal. 33: 1287-8. PMID 24825350 DOI: 10.15252/embj.201488713  0.56
2014 North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The Embo Journal. 33: 1438-53. PMID 24825348 DOI: 10.15252/embj.201386907  0.56
2014 Solon-Biet SM, McMahon AC, Ballard JW, Ruohonen K, Wu LE, Cogger VC, Warren A, Huang X, Pichaud N, Melvin RG, Gokarn R, Khalil M, Turner N, Cooney GJ, Sinclair DA, et al. The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metabolism. 19: 418-30. PMID 24606899 DOI: 10.1016/j.cmet.2014.02.009  0.56
2014 Mitchell SJ, Martin-Montalvo A, Mercken EM, Palacios HH, Ward TM, Abulwerdi G, Minor RK, Vlasuk GP, Ellis JL, Sinclair DA, Dawson J, Allison DB, Zhang Y, Becker KG, Bernier M, et al. The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet. Cell Reports. 6: 836-43. PMID 24582957 DOI: 10.1016/j.celrep.2014.01.031  0.56
2014 Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proceedings of the National Academy of Sciences of the United States of America. 111: 3781-6. PMID 24556985 DOI: 10.1073/pnas.1400705111  0.6
2014 Hubbard BP, Sinclair DA. Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends in Pharmacological Sciences. 35: 146-54. PMID 24439680 DOI: 10.1016/j.tips.2013.12.004  0.56
2014 Michan S, Juan AM, Hurst CG, Cui Z, Evans LP, Hatton CJ, Pei DT, Ju M, Sinclair DA, Smith LE, Chen J. Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy. Plos One. 9: e85031. PMID 24416337 DOI: 10.1371/journal.pone.0085031  0.56
2014 Sinclair DA, Guarente L. Small-molecule allosteric activators of sirtuins. Annual Review of Pharmacology and Toxicology. 54: 363-80. PMID 24160699 DOI: 10.1146/annurev-pharmtox-010611-134657  0.56
2014 Franco SS, De Falco L, Ghaffari S, Brugnara C, Sinclair DA, Matte' A, Iolascon A, Mohandas N, Bertoldi M, An X, Siciliano A, Rimmelé P, Cappellini MD, Michan S, Zoratti E, et al. Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice. Haematologica. 99: 267-75. PMID 23975182 DOI: 10.3324/haematol.2013.090076  0.56
2014 Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN. Flavonoid apigenin is an inhibitor of the NAD+ase CD38: Implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome (Diabetes (2013) 62 (1084-1093)) Diabetes. 63: 1428. DOI: 10.2337/db14-er04  0.56
2014 Sinclair D. Turning back time Chemistry and Industry (London). 78: 32-35. DOI: 10.1002/cind.7810-10.x  0.56
2013 Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, ... ... Sinclair DA, et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 155: 1624-38. PMID 24360282 DOI: 10.1016/j.cell.2013.11.037  0.56
2013 Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, ... ... Sinclair DA, et al. Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nature Chemical Biology. 9: 693-700. PMID 24077178 DOI: 10.1038/nchembio.1352  0.56
2013 Hubbard BP, Sinclair DA. Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay. Methods in Molecular Biology (Clifton, N.J.). 1077: 167-77. PMID 24014406 DOI: 10.1007/978-1-62703-637-5_11  0.56
2013 Sinclair DA. Studying the replicative life span of yeast cells. Methods in Molecular Biology (Clifton, N.J.). 1048: 49-63. PMID 23929097 DOI: 10.1007/978-1-62703-556-9_5  0.56
2013 Chen J, Michan S, Juan AM, Hurst CG, Hatton CJ, Pei DT, Joyal JS, Evans LP, Cui Z, Stahl A, Sapieha P, Sinclair DA, Smith LE. Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. Angiogenesis. 16: 985-92. PMID 23912262 DOI: 10.1007/s10456-013-9374-5  0.56
2013 Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, ... ... Sinclair DA, et al. Metformin improves healthspan and lifespan in mice. Nature Communications. 4: 2192. PMID 23900241 DOI: 10.1038/ncomms3192  0.56
2013 Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA. Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism. Cell Cycle (Georgetown, Tex.). 12: 2233-40. PMID 23892437 DOI: 10.4161/cc.25268  0.56
2013 Tilly JL, Sinclair DA. Germline energetics, aging, and female infertility. Cell Metabolism. 17: 838-50. PMID 23747243 DOI: 10.1016/j.cmet.2013.05.007  0.56
2013 Lai L, Yan L, Gao S, Hu CL, Ge H, Davidow A, Park M, Bravo C, Iwatsubo K, Ishikawa Y, Auwerx J, Sinclair DA, Vatner SF, Vatner DE. Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway. Circulation. 127: 1692-701. PMID 23536361 DOI: 10.1161/CIRCULATIONAHA.112.001212  0.56
2013 Biason-Lauber A, Böni-Schnetzler M, Hubbard BP, Bouzakri K, Brunner A, Cavelti-Weder C, Keller C, Meyer-Böni M, Meier DT, Brorsson C, Timper K, Leibowitz G, Patrignani A, Bruggmann R, Boily G, ... ... Sinclair DA, et al. Identification of a SIRT1 mutation in a family with type 1 diabetes. Cell Metabolism. 17: 448-55. PMID 23473037 DOI: 10.1016/j.cmet.2013.02.001  0.56
2013 Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, ... ... Sinclair DA, et al. Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (New York, N.Y.). 339: 1216-9. PMID 23471411 DOI: 10.1126/science.1231097  0.56
2013 Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Molecular and Cellular Biology. 33: 1487-502. PMID 23382074 DOI: 10.1128/MCB.00971-12  0.56
2013 Han J, Hubbard BP, Lee J, Montagna C, Lee HW, Sinclair DA, Suh Y. Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene. Cell Cycle (Georgetown, Tex.). 12: 263-70. PMID 23255128 DOI: 10.4161/cc.23056  0.56
2013 Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN. Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. 62: 1084-93. PMID 23172919 DOI: 10.2337/db12-1139  0.56
2013 Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, et al. Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 6-16. PMID 22451473 DOI: 10.1093/gerona/gls070  0.56
2012 Sinclair D, Verdin E. The longevity of sirtuins. Cell Reports. 2: 1473-4. PMID 23273894 DOI: 10.1016/j.celrep.2012.12.004  0.56
2012 Rascón B, Hubbard BP, Sinclair DA, Amdam GV. The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction. Aging. 4: 499-508. PMID 22868943  0.56
2012 Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, Horvath TL, Sinclair DA, Pfluger PT, Tschöp MH. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiological Reviews. 92: 1479-514. PMID 22811431 DOI: 10.1152/physrev.00022.2011  0.56
2012 Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, ... ... Sinclair DA, et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metabolism. 15: 675-90. PMID 22560220 DOI: 10.1016/j.cmet.2012.04.003  0.56
2012 North BJ, Sinclair DA. The intersection between aging and cardiovascular disease. Circulation Research. 110: 1097-108. PMID 22499900 DOI: 10.1161/CIRCRESAHA.111.246876  0.56
2012 Gomes AP, Duarte FV, Nunes P, Hubbard BP, Teodoro JS, Varela AT, Jones JG, Sinclair DA, Palmeira CM, Rolo AP. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. Biochimica Et Biophysica Acta. 1822: 185-95. PMID 22027215 DOI: 10.1016/j.bbadis.2011.10.008  0.56
2011 Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, ... ... Sinclair DA, et al. SRT1720 improves survival and healthspan of obese mice. Scientific Reports. 1: 70. PMID 22355589 DOI: 10.1038/srep00070  0.56
2011 Beirowski B, Gustin J, Armour SM, Yamamoto H, Viader A, North BJ, Michán S, Baloh RH, Golden JP, Schmidt RE, Sinclair DA, Auwerx J, Milbrandt J. Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proceedings of the National Academy of Sciences of the United States of America. 108: E952-61. PMID 21949390 DOI: 10.1073/pnas.1104969108  0.56
2011 Ramadori G, Fujikawa T, Anderson J, Berglund ED, Frazao R, Michán S, Vianna CR, Sinclair DA, Elias CF, Coppari R. SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. Cell Metabolism. 14: 301-12. PMID 21907137 DOI: 10.1016/j.cmet.2011.06.014  0.56
2011 Bernier M, Paul RK, Martin-Montalvo A, Scheibye-Knudsen M, Song S, He HJ, Armour SM, Hubbard BP, Bohr VA, Wang L, Zong Y, Sinclair DA, de Cabo R. Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. The Journal of Biological Chemistry. 286: 19270-9. PMID 21467030 DOI: 10.1074/jbc.M110.200311  0.56
2011 Hua J, Guerin KI, Chen J, Michán S, Stahl A, Krah NM, Seaward MR, Dennison RJ, Juan AM, Hatton CJ, Sapieha P, Sinclair DA, Smith LE. Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. Investigative Ophthalmology & Visual Science. 52: 2809-16. PMID 21282584 DOI: 10.1167/iovs.10-6496  0.56
2011 Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, De Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice Journals of Gerontology - Series a Biological Sciences and Medical Sciences. 66: 191-201. PMID 20974732 DOI: 10.1093/gerona/glq178  0.56
2011 Haigis MC, Sinclair DA. Sirtuins in aging and age-related diseases Handbook of the Biology of Aging. 243-274. DOI: 10.1016/B978-0-12-378638-8.00011-7  0.56
2010 Yang Y, Hubbard BP, Sinclair DA, Tong Q. Characterization of murine SIRT3 transcript variants and corresponding protein products. Journal of Cellular Biochemistry. 111: 1051-8. PMID 20677216 DOI: 10.1002/jcb.22795  0.56
2010 Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, ... Sinclair DA, et al. SIRT1 is essential for normal cognitive function and synaptic plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9695-707. PMID 20660252 DOI: 10.1523/JNEUROSCI.0027-10.2010  0.56
2010 Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, et al. Impact papers on aging in 2009. Aging. 2: 111-21. PMID 20351400 DOI: v2/n3/full/100132.html  0.56
2009 Blagosklonny MV, Campisi J, Sinclair DA. Aging: past, present and future. Aging. 1: 1-5. PMID 20157590 DOI: 10.18632/aging.100009  0.56
2009 Jin L, Galonek H, Israelian K, Choy W, Morrison M, Xia Y, Wang X, Xu Y, Yang Y, Smith JJ, Hoffmann E, Carney DP, Perni RB, Jirousek MR, Bemis JE, ... ... Sinclair DA, et al. Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. Protein Science : a Publication of the Protein Society. 18: 514-25. PMID 19241369 DOI: 10.1002/pro.50  0.56
2008 Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, ... ... Sinclair DA, et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metabolism. 8: 157-68. PMID 18599363 DOI: 10.1016/j.cmet.2008.06.011  0.56
2008 Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. Plos One. 3: e2020. PMID 18414679 DOI: 10.1371/journal.pone.0002020  0.56
2007 Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, ... ... Sinclair DA, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 450: 712-6. PMID 18046409 DOI: 10.1038/nature06261  0.56
2007 Medvedik O, Lamming DW, Kim KD, Sinclair DA. MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. Plos Biology. 5: e261. PMID 17914901 DOI: 10.1371/journal.pbio.0050261  0.88
2007 Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell. 130: 1095-107. PMID 17889652 DOI: 10.1016/j.cell.2007.07.035  0.56
2007 Li Y, Yokota T, Gama V, Yoshida T, Gomez JA, Ishikawa K, Sasaguri H, Cohen HY, Sinclair DA, Mizusawa H, Matsuyama S. Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation. Cell Death and Differentiation. 14: 2058-67. PMID 17885668 DOI: 10.1038/sj.cdd.4402219  0.44
2007 Medvedik O, Sinclair DA. Caloric restriction and life span determination of yeast cells. Methods in Molecular Biology (Clifton, N.J.). 371: 97-109. PMID 17634577 DOI: 10.1007/978-1-59745-361-5_9  0.88
2007 Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. The Embo Journal. 26: 3169-79. PMID 17581637 DOI: 10.1038/sj.emboj.7601758  0.56
2006 Yu MC, Lamming DW, Eskin JA, Sinclair DA, Silver PA. The role of protein arginine methylation in the formation of silent chromatin. Genes & Development. 20: 3249-54. PMID 17158743 DOI: 10.1101/gad.1495206  0.56
2006 Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, ... ... Sinclair DA, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 444: 337-42. PMID 17086191 DOI: 10.1038/nature05354  0.56
2005 Mai A, Massa S, Lavu S, Pezzi R, Simeoni S, Ragno R, Mariotti FR, Chiani F, Camilloni G, Sinclair DA. Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. Journal of Medicinal Chemistry. 48: 7789-95. PMID 16302818 DOI: 10.1021/jm050100l  0.56
2005 Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, Lin SJ, Sinclair DA. HST2 mediates SIR2-independent life-span extension by calorie restriction. Science (New York, N.Y.). 309: 1861-4. PMID 16051752 DOI: 10.1126/science.1113611  0.88
2004 Lamming DW, Wood JG, Sinclair DA. Small molecules that regulate lifespan: evidence for xenohormesis. Molecular Microbiology. 53: 1003-9. PMID 15306006 DOI: 10.1111/j.1365-2958.2004.04209.x  0.56
2004 Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, De Cabo R, Sinclair DA. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase Science. 305: 390-392. PMID 15205477 DOI: 10.1126/science.1099196  0.56
2004 Cohen HY, Lavu S, Bitterman KJ, Hekking B, Imahiyerobo TA, Miller C, Frye R, Ploegh H, Kessler BM, Sinclair DA. Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Molecular Cell. 13: 627-38. PMID 15023334 DOI: 10.1016/S1097-2765(04)00094-2  0.84
2004 Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (New York, N.Y.). 303: 2011-5. PMID 14976264 DOI: 10.1126/science.1094637  0.56
2003 Anderson RM, Latorre-Esteves M, Neves AR, Lavu S, Medvedik O, Taylor C, Howitz KT, Santos H, Sinclair DA. Yeast life-span extension by calorie restriction is independent of NAD fluctuation. Science (New York, N.Y.). 302: 2124-6. PMID 14605207 DOI: 10.1126/science.1088697  0.88
2003 Bitterman KJ, Medvedik O, Sinclair DA. Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiology and Molecular Biology Reviews : Mmbr. 67: 376-99, table of con. PMID 12966141  0.88
2003 Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 425: 191-6. PMID 12939617 DOI: 10.1038/nature01960  0.84
2003 Sinclair D. Is DNA cut out for a long life? Science of Aging Knowledge Environment : Sage Ke. 2003. PMID 12844521  0.56
2003 Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature. 423: 181-5. PMID 12736687 DOI: 10.1038/nature01578  0.88
2002 Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. The Journal of Biological Chemistry. 277: 45099-107. PMID 12297502 DOI: 10.1074/jbc.M205670200  0.84
2002 Sinclair DA. Paradigms and pitfalls of yeast longevity research Mechanisms of Ageing and Development. 123: 857-867. PMID 12044934 DOI: 10.1016/S0047-6374(02)00023-4  0.56
2002 Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA. Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. The Journal of Biological Chemistry. 277: 18881-90. PMID 11884393 DOI: 10.1074/jbc.M111773200  0.88
1999 Hong SP, Piper MD, Sinclair DA, Dawes IW. Control of expression of one-carbon metabolism genes of Saccharomyces cerevisiae is mediated by a tetrahydrofolate-responsive protein binding to a glycine regulatory region including a core 5'-CTTCTT-3' motif Journal of Biological Chemistry. 274: 10523-10532. PMID 10187845 DOI: 10.1074/jbc.274.15.10523  0.56
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