Sabine Ehrt - Publications

Weill Cornell Medical College, New York, NY, United States 
Immunology, Microbiology Biology

114 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Xu Y, Ehrt S, Schnappinger D, Beites T. Synthetic lethality of NADH dehydrogenases is due to impaired NADH oxidation. Mbio. 14: e0104523. PMID 38032200 DOI: 10.1128/mbio.01045-23  0.307
2023 Sharma R, Hartman TE, Beites T, Kim JH, Eoh H, Engelhart CA, Zhu L, Wilson DJ, Aldrich CC, Ehrt S, Rhee KY, Schnappinger D. Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in . Mbio. e0034023. PMID 37350592 DOI: 10.1128/mbio.00340-23  0.338
2022 Zhang L, Kent JE, Whitaker M, Young DC, Herrmann D, Aleshin AE, Ko YH, Cingolani G, Saad JS, Moody DB, Marassi FM, Ehrt S, Niederweis M. A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis. Nature Communications. 13: 2255. PMID 35474308 DOI: 10.1038/s41467-022-29873-6  0.423
2022 Kreutzfeldt KM, Jansen RS, Hartman TE, Gouzy A, Wang R, Krieger IV, Zimmerman MD, Gengenbacher M, Sarathy JP, Xie M, Dartois V, Sacchettini JC, Rhee KY, Schnappinger D, Ehrt S. CinA mediates multidrug tolerance in Mycobacterium tuberculosis. Nature Communications. 13: 2203. PMID 35459278 DOI: 10.1038/s41467-022-29832-1  0.356
2021 Beites T, Jansen RS, Wang R, Jinich A, Rhee KY, Schnappinger D, Ehrt S. Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection. Nature Communications. 12: 6593. PMID 34782606 DOI: 10.1038/s41467-021-26941-1  0.376
2021 Bosch B, DeJesus MA, Poulton NC, Zhang W, Engelhart CA, Zaveri A, Lavalette S, Ruecker N, Trujillo C, Wallach JB, Li S, Ehrt S, Chait BT, Schnappinger D, Rock JM. Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis. Cell. PMID 34297925 DOI: 10.1016/j.cell.2021.06.033  0.311
2021 Su H, Lin K, Tiwari D, Healy C, Trujillo C, Liu Y, Ioerger TR, Schnappinger D, Ehrt S. Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity. The Journal of Experimental Medicine. 218. PMID 34269789 DOI: 10.1084/jem.20210332  0.356
2021 Black KA, Duan L, Mandyoli L, Selbach BP, Xu W, Ehrt S, Sacchettini JC, Rhee KY. Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis. The Journal of Experimental Medicine. 218. PMID 33950161 DOI: 10.1084/jem.20191957  0.332
2020 Trasino SE, Tang XH, Trujillo C, Andres J, Ehrt S, Gudas LJ. Mycobacterium tuberculosis Infection is Exacerbated in Mice Lacking Lecithin:Retinol Acyltransferase. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 165909. PMID 32768676 DOI: 10.1016/J.Bbadis.2020.165909  0.457
2020 Zaveri A, Wang R, Botella L, Sharma R, Zhu L, Wallach JB, Song N, Jansen RS, Rhee KY, Ehrt S, Schnappinger D. Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death. Molecular Microbiology. PMID 32634279 DOI: 10.1111/Mmi.14571  0.337
2020 Whitaker M, Ruecker N, Hartman T, Klevorn T, Andres J, Kim J, Rhee K, Ehrt S. Two interacting ATPases protect from glycerol and nitric oxide toxicity. Journal of Bacteriology. PMID 32482725 DOI: 10.1128/Jb.00202-20  0.437
2020 Healy C, Gouzy A, Ehrt S. Peptidoglycan Hydrolases RipA and Ami1 Are Critical for Replication and Persistence of Mycobacterium tuberculosis in the Host. Mbio. 11. PMID 32127458 DOI: 10.1128/Mbio.03315-19  0.459
2020 Gengenbacher M, Zimmerman MD, Sarathy JP, Kaya F, Wang H, Mina M, Carter C, Hossen MA, Su H, Trujillo C, Ehrt S, Schnappinger D, Dartois V. Tissue distribution of doxycycline in animal models of tuberculosis. Antimicrobial Agents and Chemotherapy. PMID 32041718 DOI: 10.1128/Aac.02479-19  0.386
2019 Wang R, Kreutzfeldt K, Botella H, Vaubourgeix J, Schnappinger D, Ehrt S. Persistent infection in mice requires PerM for successful cell division. Elife. 8. PMID 31751212 DOI: 10.7554/Elife.49570  0.41
2019 Beites T, O'Brien K, Tiwari D, Engelhart CA, Walters S, Andrews J, Yang HJ, Sutphen ML, Weiner DM, Dayao EK, Zimmerman M, Prideaux B, Desai PV, Masquelin T, Via LE, ... ... Ehrt S, et al. Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development. Nature Communications. 10: 4970. PMID 31672993 DOI: 10.1038/S41467-019-12956-2  0.467
2019 Buter J, Cheng TY, Ghanem M, Grootemaat AE, Raman S, Feng X, Plantijn AR, Ennis T, Wang J, Cotton RN, Layre E, Ramnarine AK, Mayfield JA, Young DC, Jezek Martinot A, ... ... Ehrt S, et al. Mycobacterium tuberculosis releases an antacid that remodels phagosomes. Nature Chemical Biology. 15: 889-899. PMID 31427817 DOI: 10.1038/S41589-019-0336-0  0.476
2019 Lee JJ, Lee SK, Song N, Nathan TO, Swarts BM, Eum SY, Ehrt S, Cho SN, Eoh H. Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis. Nature Communications. 10: 2928. PMID 31266959 DOI: 10.1038/S41467-019-10975-7  0.421
2019 Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, ... ... Ehrt S, et al. Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes. Nature. PMID 31217586 DOI: 10.1038/S41586-019-1315-Z  0.369
2019 Wang R, Kreutzfeldt K, Botella H, Vaubourgeix J, Schnappinger D, Ehrt S. Author response: Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division Elife. DOI: 10.7554/Elife.49570.Sa2  0.448
2018 Wescott HH, Zuniga ES, Bajpai A, Trujillo C, Ehrt S, Schnappinger D, Roberts DM, Parish T. Identification of Enolase as the Target of 2-Aminothiazoles in . Frontiers in Microbiology. 9: 2542. PMID 30416491 DOI: 10.3389/Fmicb.2018.02542  0.364
2018 Tiwari D, Park SW, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HP, Engelhart CA, Ioerger T, Sacchettini JC, Rhee K, Ehrt S, Aldrich CC, et al. Targeting protein biotinylation enhances tuberculosis chemotherapy. Science Translational Medicine. 10. PMID 29695454 DOI: 10.1126/Scitranslmed.Aal1803  0.427
2018 Ehrt S, Schnappinger D, Rhee KY. Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis. Nature Reviews. Microbiology. PMID 29691481 DOI: 10.1038/S41579-018-0013-4  0.479
2018 Ngadjeua F, Braud E, Saidjalolov S, Iannazzo L, Schnappinger D, Ehrt S, Hugonnet JE, Mengin-Lecreulx D, Patin DP, Ethève-Quelquejeu M, Fonvielle M, Arthur M. Critical impact of peptidoglycan precursor amidation on the activity of L,D-transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29389045 DOI: 10.1002/Chem.201706082  0.379
2017 Botella H, Yang G, Ouerfelli O, Ehrt S, Nathan CF, Vaubourgeix J. Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis. Mbio. 8. PMID 28900018 DOI: 10.1128/Mbio.01183-17  0.475
2017 Xu W, DeJesus MA, Rücker N, Engelhart CA, Wright MG, Healy C, Lin K, Wang R, Park SW, Ioerger TR, Schnappinger D, Ehrt S. Chemical genomic interaction profiling reveals determinants of intrinsic antibiotic resistance in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. PMID 28893793 DOI: 10.1128/Aac.01334-17  0.473
2017 Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt S. Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28265055 DOI: 10.1073/Pnas.1617655114  0.402
2017 Ruecker N, Jansen R, Trujillo C, Puckett S, Jayachandran P, Piroli GG, Frizzell N, Molina H, Rhee KY, Ehrt S. Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis. Cell Chemical Biology. PMID 28219662 DOI: 10.1016/J.Chembiol.2017.01.005  0.472
2017 Mitra A, Speer A, Lin K, Ehrt S, Niederweis M. PPE Surface Proteins Are Required for Heme Utilization by Mycobacterium tuberculosis. Mbio. 8. PMID 28119467 DOI: 10.1128/Mbio.01720-16  0.51
2017 DeJesus MA, Gerrick ER, Xu W, Park SW, Long JE, Boutte CC, Rubin EJ, Schnappinger D, Ehrt S, Fortune SM, Sassetti CM, Ioerger TR. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mbio. 8. PMID 28096490 DOI: 10.1128/Mbio.02133-16  0.372
2017 Botella H, Vaubourgeix J, Lee MH, Song N, Xu W, Makinoshima H, Glickman MS, Ehrt S. Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress. The Embo Journal. PMID 28057704 DOI: 10.15252/Embj.201695028  0.431
2016 Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR, Bornemann S, Ioerger TR, Ehrt S, Kalscheuer R. Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice. Plos Pathogens. 12: e1006043. PMID 27936238 DOI: 10.1371/Journal.Ppat.1006043  0.546
2016 Schnappinger D, Ehrt S. A broader spectrum of tuberculosis. Nature Medicine. 22: 1076-1077. PMID 27711059 DOI: 10.1038/Nm.4186  0.46
2016 Evans JC, Trujillo C, Wang Z, Eoh H, Ehrt S, Schnappinger D, Boshoff HI, Rhee KY, Barry 3rd CE, Mizrahi V. Validation of CoaBC as a bactericidal target in the coenzyme A pathway of Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 27676316 DOI: 10.1021/Acsinfecdis.6B00150  0.529
2016 Lin K, O'Brien KM, Trujillo C, Wang R, Wallach JB, Schnappinger D, Ehrt S. Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense. Plos Pathogens. 12: e1005675. PMID 27249779 DOI: 10.1371/Journal.Ppat.1005675  0.475
2016 Mizrahi V, Evans J, Trujillo C, Eoh H, Ehrt S, Schnappinger D, Boshoff H, Rhee K, Barry CE. Identifying vulnerable steps in the coenzyme A biosynthesis pathway of M. tuberculosis The Faseb Journal. 30. DOI: 10.1096/Fasebj.30.1_Supplement.242.2  0.427
2015 Ganapathy U, Marrero J, Calhoun S, Eoh H, de Carvalho LP, Rhee K, Ehrt S. Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis. Nature Communications. 6: 7912. PMID 26258286 DOI: 10.1038/Ncomms8912  0.482
2015 Speer A, Sun J, Danilchanka O, Meikle V, Rowland JL, Walter K, Buck BR, Pavlenok M, Hölscher C, Ehrt S, Niederweis M. Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages. Molecular Microbiology. 97: 881-97. PMID 26036301 DOI: 10.1111/Mmi.13073  0.43
2015 Zhao N, Sun M, Burns-Huang K, Jiang X, Ling Y, Darby C, Ehrt S, Liu G, Nathan C. Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis. Plos One. 10: e0126211. PMID 25978362 DOI: 10.1371/Journal.Pone.0126211  0.398
2015 Schnappinger D, O'Brien KM, Ehrt S. Construction of conditional knockdown mutants in mycobacteria. Methods in Molecular Biology (Clifton, N.J.). 1285: 151-75. PMID 25779315 DOI: 10.1007/978-1-4939-2450-9_9  0.417
2015 Ehrt S, Rhee K, Schnappinger D. Mycobacterial genes essential for the pathogen's survival in the host. Immunological Reviews. 264: 319-26. PMID 25703569 DOI: 10.1111/Imr.12256  0.403
2015 Goodsmith N, Guo XV, Vandal OH, Vaubourgeix J, Wang R, Botella H, Song S, Bhatt K, Liba A, Salgame P, Schnappinger D, Ehrt S. Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice. Plos Pathogens. 11: e1004645. PMID 25658098 DOI: 10.1371/Journal.Ppat.1004645  0.509
2015 Zhao N, Darby CM, Small J, Bachovchin DA, Jiang X, Burns-Huang KE, Botella H, Ehrt S, Boger DL, Anderson ED, Cravatt BF, Speers AE, Fernandez-Vega V, Hodder PS, Eberhart C, et al. Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis. Acs Chemical Biology. 10: 364-71. PMID 25457457 DOI: 10.1021/Cb500746Z  0.678
2014 Schnappinger D, Ehrt S. Regulated Expression Systems for Mycobacteria and Their Applications. Microbiology Spectrum. 2: MGM2-0018-2013. PMID 26082123 DOI: 10.1128/Microbiolspec.Mgm2-0018-2013  0.364
2014 Gaur RL, Ren K, Blumenthal A, Bhamidi S, González-Nilo FD, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst JD, Banaei N. LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis. Plos Pathogens. 10: e1004376. PMID 25232742 DOI: 10.1371/Journal.Ppat.1004376  0.492
2014 Puckett S, Trujillo C, Eoh H, Marrero J, Spencer J, Jackson M, Schnappinger D, Rhee K, Ehrt S. Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis. Plos Pathogens. 10: e1004144. PMID 24851864 DOI: 10.1371/Journal.Ppat.1004144  0.41
2014 Trujillo C, Blumenthal A, Marrero J, Rhee KY, Schnappinger D, Ehrt S. Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection. Mbio. 5: e00085. PMID 24757211 DOI: 10.1128/Mbio.00085-14  0.494
2014 Danilchanka O, Sun J, Pavlenok M, Maueröder C, Speer A, Siroy A, Marrero J, Trujillo C, Mayhew DL, Doornbos KS, Muñoz LE, Herrmann M, Ehrt S, Berens C, Niederweis M. An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity. Proceedings of the National Academy of Sciences of the United States of America. 111: 6750-5. PMID 24753609 DOI: 10.1073/Pnas.1400136111  0.481
2014 Gaur RL, Ren K, Blumenthal A, Bhamidi S, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst JD, Banaei N. Correction: LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis (vol 10, e1004376, 2014) Plos Pathogens. 10. DOI: 10.1371/Journal.Ppat.1004489  0.405
2013 Kim JH, O'Brien KM, Sharma R, Boshoff HI, Rehren G, Chakraborty S, Wallach JB, Monteleone M, Wilson DJ, Aldrich CC, Barry CE, Rhee KY, Ehrt S, Schnappinger D. A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence. Proceedings of the National Academy of Sciences of the United States of America. 110: 19095-100. PMID 24191058 DOI: 10.1073/Pnas.1315860110  0.509
2013 Small JL, Park SW, Kana BD, Ioerger TR, Sacchettini JC, Ehrt S. Perturbation of cytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis. Mbio. 4: e00475-13. PMID 24045640 DOI: 10.1128/Mbio.00475-13  0.713
2013 Darby CM, Ingólfsson HI, Jiang X, Shen C, Sun M, Zhao N, Burns K, Liu G, Ehrt S, Warren JD, Andersen OS, Anderson OS, Brickner SJ, Nathan C. Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis. Plos One. 8: e68942. PMID 23935911 DOI: 10.1371/Journal.Pone.0068942  0.442
2013 Small JL, O'Donoghue AJ, Boritsch EC, Tsodikov OV, Knudsen GM, Vandal O, Craik CS, Ehrt S. Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis. The Journal of Biological Chemistry. 288: 12489-99. PMID 23504313 DOI: 10.1074/Jbc.M113.456541  0.681
2013 Marrero J, Trujillo C, Rhee KY, Ehrt S. Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice. Plos Pathogens. 9: e1003116. PMID 23326232 DOI: 10.1371/Journal.Ppat.1003116  0.372
2013 Sakamoto K, Kim MJ, Rhoades ER, Allavena RE, Ehrt S, Wainwright HC, Russell DG, Rohde KH. Mycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases. Infection and Immunity. 81: 764-76. PMID 23264051 DOI: 10.1128/Iai.00906-12  0.395
2013 Ehrt S, Rhee K. Mycobacterium tuberculosis metabolism and host interaction: mysteries and paradoxes. Current Topics in Microbiology and Immunology. 374: 163-88. PMID 23242856 DOI: 10.1007/82_2012_299  0.461
2013 Darby CM, Ingólfsson HI, Jiang X, Shen C, Sun M, Zhao N, Burns K, Liu G, Ehrt S, Warren JD, Andersen OS, Brickner SJ, Nathan C. Correction: Whole Cell Screen for Inhibitors of pH Homeostasis in Mycobacterium tuberculosis Plos One. 8. DOI: 10.1371/Annotation/760B5B07-4922-42C4-B33A-162C1E9Ae188  0.392
2012 Robertson BD, Altmann D, Barry C, Bishai B, Cole S, Dick T, Duncan K, Dye C, Ehrt S, Esmail H, Flynn J, Hafner R, Handley G, Hanekom W, van Helden P, et al. Detection and treatment of subclinical tuberculosis. Tuberculosis (Edinburgh, Scotland). 92: 447-52. PMID 22819716 DOI: 10.1016/J.Tube.2012.06.004  0.397
2012 Blumenthal A, Nagalingam G, Huch JH, Walker L, Guillemin GJ, Smythe GA, Ehrt S, Britton WJ, Saunders BM. M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. Plos One. 7: e37314. PMID 22649518 DOI: 10.1371/Journal.Pone.0037314  0.538
2011 Woong Park S, Klotzsche M, Wilson DJ, Boshoff HI, Eoh H, Manjunatha U, Blumenthal A, Rhee K, Barry CE, Aldrich CC, Ehrt S, Schnappinger D. Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression. Plos Pathogens. 7: e1002264. PMID 21980288 DOI: 10.1371/Journal.Ppat.1002264  0.531
2011 de la Paz Santangelo M, Gest PM, Guerin ME, Coinçon M, Pham H, Ryan G, Puckett SE, Spencer JS, Gonzalez-Juarrero M, Daher R, Lenaerts AJ, Schnappinger D, Therisod M, Ehrt S, Sygusch J, et al. Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli. The Journal of Biological Chemistry. 286: 40219-31. PMID 21949126 DOI: 10.1074/Jbc.M111.259440  0.504
2011 Darby CM, Venugopal A, Ehrt S, Nathan CF. Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice. Tuberculosis (Edinburgh, Scotland). 91: 343-7. PMID 21778115 DOI: 10.1016/J.Tube.2011.06.007  0.463
2011 Rhee KY, de Carvalho LP, Bryk R, Ehrt S, Marrero J, Park SW, Schnappinger D, Venugopal A, Nathan C. Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends in Microbiology. 19: 307-14. PMID 21561773 DOI: 10.1016/J.Tim.2011.03.008  0.409
2011 Koo MS, Manca C, Yang G, O'Brien P, Sung N, Tsenova L, Subbian S, Fallows D, Muller G, Ehrt S, Kaplan G. Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice. Plos One. 6: e17091. PMID 21364878 DOI: 10.1371/Journal.Pone.0017091  0.475
2011 Venugopal A, Bryk R, Shi S, Rhee K, Rath P, Schnappinger D, Ehrt S, Nathan C. Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. Cell Host & Microbe. 9: 21-31. PMID 21238944 DOI: 10.1016/J.Chom.2010.12.004  0.48
2010 Blumenthal A, Trujillo C, Ehrt S, Schnappinger D. Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo. Plos One. 5: e15667. PMID 21203517 DOI: 10.1371/Journal.Pone.0015667  0.451
2010 Tan MP, Sequeira P, Lin WW, Phong WY, Cliff P, Ng SH, Lee BH, Camacho L, Schnappinger D, Ehrt S, Dick T, Pethe K, Alonso S. Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses. Plos One. 5: e13356. PMID 21048946 DOI: 10.1371/Journal.Pone.0013356  0.457
2010 de Carvalho LP, Fischer SM, Marrero J, Nathan C, Ehrt S, Rhee KY. Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates. Chemistry & Biology. 17: 1122-31. PMID 21035735 DOI: 10.1016/J.Chembiol.2010.08.009  0.355
2010 Biswas T, Small J, Vandal O, Odaira T, Deng H, Ehrt S, Tsodikov OV. Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress. Structure (London, England : 1993). 18: 1353-63. PMID 20947023 DOI: 10.1016/J.Str.2010.06.017  0.695
2010 Seimon TA, Kim MJ, Blumenthal A, Koo J, Ehrt S, Wainwright H, Bekker LG, Kaplan G, Nathan C, Tabas I, Russell DG. Induction of ER stress in macrophages of tuberculosis granulomas. Plos One. 5: e12772. PMID 20856677 DOI: 10.1371/Journal.Pone.0012772  0.441
2010 Gandotra S, Lebron MB, Ehrt S. The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide. Plos Pathogens. 6: e1001040. PMID 20711362 DOI: 10.1371/Journal.Ppat.1001040  0.718
2010 Marrero J, Rhee KY, Schnappinger D, Pethe K, Ehrt S. Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection. Proceedings of the National Academy of Sciences of the United States of America. 107: 9819-24. PMID 20439709 DOI: 10.1073/Pnas.1000715107  0.43
2010 Barry CE, Boshoff HI, Dartois V, Dick T, Ehrt S, Flynn J, Schnappinger D, Wilkinson RJ, Young D. Spectrum of latent tuberculosis existing tests cannot resolve the underlying phenotypes: Author's reply Nature Reviews Microbiology. 8: 242. DOI: 10.1038/Nrmicro2236-C2  0.376
2009 Barry CE, Boshoff HI, Dartois V, Dick T, Ehrt S, Flynn J, Schnappinger D, Wilkinson RJ, Young D. The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nature Reviews. Microbiology. 7: 845-55. PMID 19855401 DOI: 10.1038/Nrmicro2236  0.476
2009 Vandal OH, Nathan CF, Ehrt S. Acid resistance in Mycobacterium tuberculosis. Journal of Bacteriology. 191: 4714-21. PMID 19465648 DOI: 10.1128/Jb.00305-09  0.493
2009 Ehrt S, Schnappinger D. Mycobacterial survival strategies in the phagosome: defence against host stresses. Cellular Microbiology. 11: 1170-8. PMID 19438516 DOI: 10.1111/J.1462-5822.2009.01335.X  0.451
2009 Klotzsche M, Ehrt S, Schnappinger D. Improved tetracycline repressors for gene silencing in mycobacteria. Nucleic Acids Research. 37: 1778-88. PMID 19174563 DOI: 10.1093/Nar/Gkp015  0.427
2009 Blumenthal A, Kobayashi T, Pierini LM, Banaei N, Ernst JD, Miyake K, Ehrt S. RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins. Cell Host & Microbe. 5: 35-46. PMID 19154986 DOI: 10.1016/J.Chom.2008.12.002  0.386
2009 Vandal OH, Roberts JA, Odaira T, Schnappinger D, Nathan CF, Ehrt S. Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment. Journal of Bacteriology. 191: 625-31. PMID 19011036 DOI: 10.1128/Jb.00932-08  0.494
2008 Vandal OH, Pierini LM, Schnappinger D, Nathan CF, Ehrt S. A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis. Nature Medicine. 14: 849-54. PMID 18641659 DOI: 10.1038/Nm.1795  0.429
2008 Boshoff HI, Xu X, Tahlan K, Dowd CS, Pethe K, Camacho LR, Park TH, Yun CS, Schnappinger D, Ehrt S, Williams KJ, Barry CE. Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli. The Journal of Biological Chemistry. 283: 19329-41. PMID 18490451 DOI: 10.1074/Jbc.M800694200  0.537
2008 Bryk R, Gold B, Venugopal A, Singh J, Samy R, Pupek K, Cao H, Popescu C, Gurney M, Hotha S, Cherian J, Rhee K, Ly L, Converse PJ, Ehrt S, et al. Selective killing of nonreplicating mycobacteria. Cell Host & Microbe. 3: 137-45. PMID 18329613 DOI: 10.1016/J.Chom.2008.02.003  0.441
2007 Gandotra S, Schnappinger D, Monteleone M, Hillen W, Ehrt S. In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice. Nature Medicine. 13: 1515-20. PMID 18059281 DOI: 10.1038/Nm1683  0.719
2007 Gandotra S, Jang S, Murray PJ, Salgame P, Ehrt S. Nucleotide-binding oligomerization domain protein 2-deficient mice control infection with Mycobacterium tuberculosis. Infection and Immunity. 75: 5127-34. PMID 17709422 DOI: 10.1128/Iai.00458-07  0.723
2007 Guo XV, Monteleone M, Klotzsche M, Kamionka A, Hillen W, Braunstein M, Ehrt S, Schnappinger D. Silencing Mycobacterium smegmatis by using tetracycline repressors. Journal of Bacteriology. 189: 4614-23. PMID 17483222 DOI: 10.1128/Jb.00216-07  0.379
2007 Ehrt S, Schnappinger D. Mycobacterium tuberculosis virulence: lipids inside and out. Nature Medicine. 13: 284-5. PMID 17342139 DOI: 10.1038/Nm0307-284  0.415
2006 Ehrt S, Schnappinger D. Controlling gene expression in mycobacteria. Future Microbiology. 1: 177-84. PMID 17661663 DOI: 10.2217/17460913.1.2.177  0.439
2006 Schnappinger D, Schoolnik GK, Ehrt S. Expression profiling of host pathogen interactions: how Mycobacterium tuberculosis and the macrophage adapt to one another. Microbes and Infection / Institut Pasteur. 8: 1132-40. PMID 16517202 DOI: 10.1016/J.Micinf.2005.10.027  0.501
2006 Vandal OH, Gelb MH, Ehrt S, Nathan CF. Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in vitro. Infection and Immunity. 74: 1751-6. PMID 16495548 DOI: 10.1128/Iai.74.3.1751-1756.2006  0.518
2006 Shi S, Ehrt S. Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis. Infection and Immunity. 74: 56-63. PMID 16368957 DOI: 10.1128/Iai.74.1.56-63.2006  0.502
2005 Ding A, Yu H, Yang J, Shi S, Ehrt S. Induction of macrophage-derived SLPI by Mycobacterium tuberculosis depends on TLR2 but not MyD88. Immunology. 116: 381-9. PMID 16236128 DOI: 10.1111/J.1365-2567.2005.02238.X  0.52
2005 Shi S, Blumenthal A, Hickey CM, Gandotra S, Levy D, Ehrt S. Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1. Journal of Immunology (Baltimore, Md. : 1950). 175: 3318-28. PMID 16116224 DOI: 10.4049/Jimmunol.175.5.3318  0.672
2005 Morris RP, Nguyen L, Gatfield J, Visconti K, Nguyen K, Schnappinger D, Ehrt S, Liu Y, Heifets L, Pieters J, Schoolnik G, Thompson CJ. Ancestral antibiotic resistance in Mycobacterium tuberculosis Proceedings of the National Academy of Sciences of the United States of America. 102: 12200-12205. PMID 16103351 DOI: 10.1073/Pnas.0505446102  0.495
2005 Hisert KB, MacCoss M, Shiloh MU, Darwin KH, Singh S, Jones RA, Ehrt S, Zhang Z, Gaffney BL, Gandotra S, Holden DW, Murray D, Nathan C. A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP. Molecular Microbiology. 56: 1234-45. PMID 15882417 DOI: 10.1111/J.1365-2958.2005.04632.X  0.667
2005 Ehrt S, Guo XV, Hickey CM, Ryou M, Monteleone M, Riley LW, Schnappinger D. Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor. Nucleic Acids Research. 33: e21. PMID 15687379 DOI: 10.1093/Nar/Gni013  0.444
2003 Darwin KH, Ehrt S, Gutierrez-Ramos JC, Weich N, Nathan CF. The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide. Science (New York, N.Y.). 302: 1963-6. PMID 14671303 DOI: 10.1126/Science.1091176  0.504
2003 Shimono N, Morici L, Casali N, Cantrell S, Sidders B, Ehrt S, Riley LW. Hypervirulent mutant of Mycobacterium tuberculosis resulting from disruption of the mce1 operon. Proceedings of the National Academy of Sciences of the United States of America. 100: 15918-23. PMID 14663145 DOI: 10.1073/Pnas.2433882100  0.466
2003 Shi S, Nathan C, Schnappinger D, Drenkow J, Fuortes M, Block E, Ding A, Gingeras TR, Schoolnik G, Akira S, Takeda K, Ehrt S. MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis. The Journal of Experimental Medicine. 198: 987-97. PMID 14517275 DOI: 10.1084/Jem.20030603  0.433
2003 Schnappinger D, Ehrt S, Voskuil MI, Liu Y, Mangan JA, Monahan IM, Dolganov G, Efron B, Butcher PD, Nathan C, Schoolnik GK. Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. The Journal of Experimental Medicine. 198: 693-704. PMID 12953091 DOI: 10.1084/Jem.20030846  0.472
2002 Ehrt S, Schnappinger D, Voskuil MI, Schoolnik GK. Genome-wide expression profiling of intracellular bacteria: The interaction of Mycobacterium tuberculosis with macrophages Methods in Microbiology. 32: 169-180. DOI: 10.1016/S0580-9517(02)32092-0  0.382
2001 Kaps I, Ehrt S, Seeber S, Schnappinger D, Martin C, Riley LW, Niederweis M. Energy transfer between fluorescent proteins using a co-expression system in Mycobacterium smegmatis Gene. 278: 115-124. PMID 11707328 DOI: 10.1016/S0378-1119(01)00712-0  0.317
2001 Ehrt S, Schnappinger D, Bekiranov S, Drenkow J, Shi S, Gingeras TR, Gaasterland T, Schoolnik G, Nathan C. Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase. The Journal of Experimental Medicine. 194: 1123-40. PMID 11602641 DOI: 10.1084/Jem.194.8.1123  0.45
2001 Chitale S, Ehrt S, Kawamura I, Fujimura T, Shimono N, Anand N, Lu S, Cohen-Gould L, Riley LW. Recombinant Mycobacterium tuberculosis protein associated with mammalian cell entry Cellular Microbiology. 3: 247-254. PMID 11298648 DOI: 10.1046/J.1462-5822.2001.00110.X  0.48
2000 Stewart GR, Ehrt S, Riley LW, Dale JW, McFadden J. Deletion of the putative antioxidant noxR1 does not alter the virulence of Mycobacterium tuberculosis H37Rv Tubercle and Lung Disease. 80: 237-242. PMID 11052913 DOI: 10.1054/Tuld.2000.0251  0.503
2000 Buchmeier N, Blanc-Potard A, Ehrt S, Piddington D, Riley L, Groisman EA. A parallel intraphagosomal survival strategy shared by Mycobacterium tuberculosis and Salmonella enterica Molecular Microbiology. 35: 1375-1382. PMID 10760138 DOI: 10.1046/J.1365-2958.2000.01797.X  0.538
1999 Niederweis M, Ehrt S, Heinz C, Klöcker U, Karosi S, Swiderek KM, Riley LW, Benz R. Cloning of the mspA gene encoding a porin from Mycobacterium smegmatis Molecular Microbiology. 33: 933-945. PMID 10476028 DOI: 10.1046/J.1365-2958.1999.01472.X  0.325
1999 Ruan J, St John G, Ehrt S, Riley L, Nathan C. noxR3, a novel gene from Mycobacterium tuberculosis, protects Salmonella typhimurium from nitrosative and oxidative stress. Infection and Immunity. 67: 3276-83. PMID 10377101 DOI: 10.1128/Iai.67.7.3276-3283.1999  0.518
1999 Ruan J, St. John G, Ehrt S, Riley L, Nathan C. noxR3, a Novel Gene fromMycobacterium tuberculosis, Protects Salmonella typhimurium from Nitrosative and Oxidative Stress Infection and Immunity. 67: 3276-3283. DOI: 10.1128/iai.67.7.3276-3283.1999  0.422
1999 Ruan J, St. John G, Ehrt S, Riley L, Nathan C. NoxR3, a novel gene from Mycobacterium tuberculosis, protects Salmonella typhimurium from nitrosative and oxidative stress International Journal of Leprosy and Other Mycobacterial Diseases. 67: 508.  0.427
1997 Ehrt S, Shiloh MU, Ruan J, Choi M, Gunzburg S, Nathan C, Xie Q, Riley LW. A novel antioxidant gene from Mycobacterium tuberculosis. The Journal of Experimental Medicine. 186: 1885-96. PMID 9382887 DOI: 10.1084/Jem.186.11.1885  0.486
1997 Schirmer F, Ehrt S, Hillen W. Expression, inducer spectrum, domain structure, and function of MopR, the regulator of phenol degradation in Acinetobacter calcoaceticus NCIB8250 Journal of Bacteriology. 179: 1329-1336. PMID 9023219 DOI: 10.1128/Jb.179.4.1329-1336.1997  0.313
1995 Ehrt S, Schirmer F, Hillen W. Genetic organization, nucleotide sequence and regulation of expression of genes encoding phenol hydroxylase and catechol 1,2-dioxygenase in Acinetobacter calcoaceticus NCIB8250 Molecular Microbiology. 18: 13-20. PMID 8596453 DOI: 10.1111/J.1365-2958.1995.Mmi_18010013.X  0.307
1995 Geissdörfer W, Frosch SC, Haspel G, Ehrt S, Hillen W. Two genes encoding proteins with similarities to rubredoxin and rubredoxin reductase are required for conversion of dodecane to lauric acid in Acinetobacter calcoaceticus ADP1. Microbiology (Reading, England). 141: 1425-32. PMID 7670642 DOI: 10.1099/13500872-141-6-1425  0.356
1994 Ehrt S, Ornston LN, Hillen W. RpoN (sigma 54) is required for conversion of phenol to catechol in Acinetobacter calcoaceticus. Journal of Bacteriology. 176: 3493-9. PMID 8206826 DOI: 10.1128/Jb.176.12.3493-3499.1994  0.325
1994 Ehrt S, Hillen W. UDP-N-acetylglucosamine 1-carboxyvinyl-transferase from Acinetobacter calcoaceticus Fems Microbiology Letters. 117: 137-142. PMID 8181716 DOI: 10.1111/J.1574-6968.1994.Tb06755.X  0.31
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