Darren Edward Higgins - Publications

Harvard University, Cambridge, MA, United States 
Microbiology Biology

40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Picard MD, Bodmer JL, Gierahn TM, Lee A, Price J, Cohane K, Clemens V, DeVault VL, Gurok G, Kohberger R, Higgins DE, Siber GR, Flechtner JB, Geisler WM. Resolution of Chlamydia trachomatis Infection Is Associated with a Distinct T Cell Response Profile. Clinical and Vaccine Immunology : Cvi. 22: 1206-18. PMID 26446421 DOI: 10.1128/CVI.00247-15  1
2015 Cemma M, Lam GY, Stöckli M, Higgins DE, Brumell JH. Strain-Specific Interactions of Listeria monocytogenes with the Autophagy System in Host Cells. Plos One. 10: e0125856. PMID 25970638 DOI: 10.1371/journal.pone.0125856  1
2015 Fattouh R, Kwon H, Czuczman MA, Copeland JW, Pelletier L, Quinlan ME, Muise AM, Higgins DE, Brumell JH. The diaphanous-related formins promote protrusion formation and cell-to-cell spread of Listeria monocytogenes. The Journal of Infectious Diseases. 211: 1185-95. PMID 25281757 DOI: 10.1093/infdis/jiu546  1
2014 Alonso AN, Perry KJ, Regeimbal JM, Regan PM, Higgins DE. Identification of Listeria monocytogenes determinants required for biofilm formation. Plos One. 9: e113696. PMID 25517120 DOI: 10.1371/journal.pone.0113696  1
2014 Czuczman MA, Fattouh R, van Rijn JM, Canadien V, Osborne S, Muise AM, Kuchroo VK, Higgins DE, Brumell JH. Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread. Nature. 509: 230-4. PMID 24739967 DOI: 10.1038/nature13168  1
2013 Lam GY, Cemma M, Muise AM, Higgins DE, Brumell JH. Host and bacterial factors that regulate LC3 recruitment to Listeria monocytogenes during the early stages of macrophage infection. Autophagy. 9: 985-95. PMID 23584039 DOI: 10.4161/auto.24406  1
2012 Chen L, Chen Z, Baker K, Halvorsen EM, da Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JW, ... ... Higgins DE, et al. The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity. 37: 930-46. PMID 23123061 DOI: 10.1016/j.immuni.2012.07.016  1
2012 Lam GY, Czuczman MA, Higgins DE, Brumell JH. Interactions of Listeria monocytogenes with the autophagy system of host cells. Advances in Immunology. 113: 7-18. PMID 22244576 DOI: 10.1016/B978-0-12-394590-7.00008-7  1
2011 Lam GY, Fattouh R, Muise AM, Grinstein S, Higgins DE, Brumell JH. Listeriolysin O suppresses phospholipase C-mediated activation of the microbicidal NADPH oxidase to promote Listeria monocytogenes infection. Cell Host & Microbe. 10: 627-34. PMID 22177565 DOI: 10.1016/j.chom.2011.11.005  1
2011 Kamp HD, Higgins DE. A protein thermometer controls temperature-dependent transcription of flagellar motility genes in Listeria monocytogenes. Plos Pathogens. 7: e1002153. PMID 21829361 DOI: 10.1371/journal.ppat.1002153  1
2011 Moffitt KL, Gierahn TM, Lu YJ, Gouveia P, Alderson M, Flechtner JB, Higgins DE, Malley R. T(H)17-based vaccine design for prevention of Streptococcus pneumoniae colonization. Cell Host & Microbe. 9: 158-65. PMID 21320698 DOI: 10.1016/j.chom.2011.01.007  1
2009 Kamp HD, Higgins DE. Transcriptional and post-transcriptional regulation of the GmaR antirepressor governs temperature-dependent control of flagellar motility in Listeria monocytogenes. Molecular Microbiology. 74: 421-35. PMID 19796338 DOI: 10.1111/j.1365-2958.2009.06874.x  1
2009 Burrack LS, Harper JW, Higgins DE. Perturbation of vacuolar maturation promotes listeriolysin O-independent vacuolar escape during Listeria monocytogenes infection of human cells. Cellular Microbiology. 11: 1382-98. PMID 19500109 DOI: 10.1111/j.1462-5822.2009.01338.x  1
2009 Shen A, Higgins DE, Panne D. Recognition of AT-rich DNA binding sites by the MogR repressor. Structure (London, England : 1993). 17: 769-77. PMID 19446532 DOI: 10.1016/j.str.2009.02.018  0.36
2008 Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 134: 743-56. PMID 18775308 DOI: 10.1016/j.cell.2008.07.021  1
2008 Smithey MJ, Brandt S, Freitag NE, Higgins DE, Bouwer HG. Stimulation of enhanced CD8 T cell responses following immunization with a hyper-antigen secreting intracytosolic bacterial pathogen. Journal of Immunology (Baltimore, Md. : 1950). 180: 3406-16. PMID 18292567  1
2008 Birmingham CL, Higgins DE, Brumell JH. Avoiding death by autophagy: interactions of Listeria monocytogenes with the macrophage autophagy system. Autophagy. 4: 368-71. PMID 18216493  1
2008 Birmingham CL, Canadien V, Kaniuk NA, Steinberg BE, Higgins DE, Brumell JH. Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles. Nature. 451: 350-4. PMID 18202661 DOI: 10.1038/nature06479  1
2007 Birmingham CL, Canadien V, Gouin E, Troy EB, Yoshimori T, Cossart P, Higgins DE, Brumell JH. Listeria monocytogenes evades killing by autophagy during colonization of host cells. Autophagy. 3: 442-51. PMID 17568179  1
2007 Lemon KP, Higgins DE, Kolter R. Flagellar motility is critical for Listeria monocytogenes biofilm formation. Journal of Bacteriology. 189: 4418-24. PMID 17416647 DOI: 10.1128/JB.01967-06  1
2007 Burrack LS, Higgins DE. Genomic approaches to understanding bacterial virulence. Current Opinion in Microbiology. 10: 4-9. PMID 17161645 DOI: 10.1016/j.mib.2006.11.004  1
2006 Shen A, Kamp HD, Gründling A, Higgins DE. A bifunctional O-GlcNAc transferase governs flagellar motility through anti-repression. Genes & Development. 20: 3283-95. PMID 17158746 DOI: 10.1101/gad.1492606  1
2006 Roan NR, Gierahn TM, Higgins DE, Starnbach MN. Monitoring the T cell response to genital tract infection. Proceedings of the National Academy of Sciences of the United States of America. 103: 12069-74. PMID 16880389 DOI: 10.1073/pnas.0603866103  1
2006 Shen A, Higgins DE. The MogR transcriptional repressor regulates nonhierarchal expression of flagellar motility genes and virulence in Listeria monocytogenes. Plos Pathogens. 2: e30. PMID 16617375 DOI: 10.1371/journal.ppat.0020030  1
2006 Henry R, Shaughnessy L, Loessner MJ, Alberti-Segui C, Higgins DE, Swanson JA. Cytolysin-dependent delay of vacuole maturation in macrophages infected with Listeria monocytogenes. Cellular Microbiology. 8: 107-19. PMID 16367870 DOI: 10.1111/j.1462-5822.2005.00604.x  1
2005 Shen A, Higgins DE. The 5' untranslated region-mediated enhancement of intracellular listeriolysin O production is required for Listeria monocytogenes pathogenicity. Molecular Microbiology. 57: 1460-73. PMID 16102013 DOI: 10.1111/j.1365-2958.2005.04780.x  1
2005 Li Z, Zhao X, Higgins DE, Frankel FR. Conditional lethality yields a new vaccine strain of Listeria monocytogenes for the induction of cell-mediated immunity. Infection and Immunity. 73: 5065-73. PMID 16041022 DOI: 10.1128/IAI.73.8.5065-5073.2005  1
2005 Agaisse H, Burrack LS, Philips JA, Rubin EJ, Perrimon N, Higgins DE. Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science (New York, N.Y.). 309: 1248-51. PMID 16020693 DOI: 10.1126/science.1116008  1
2004 Gründling A, Burrack LS, Bouwer HG, Higgins DE. Listeria monocytogenes regulates flagellar motility gene expression through MogR, a transcriptional repressor required for virulence. Proceedings of the National Academy of Sciences of the United States of America. 101: 12318-23. PMID 15302931 DOI: 10.1073/pnas.0404924101  1
2004 Starks H, Bruhn KW, Shen H, Barry RA, Dubensky TW, Brockstedt D, Hinrichs DJ, Higgins DE, Miller JF, Giedlin M, Bouwer HG. Listeria monocytogenes as a vaccine vector: virulence attenuation or existing antivector immunity does not diminish therapeutic efficacy. Journal of Immunology (Baltimore, Md. : 1950). 173: 420-7. PMID 15210801  1
2004 Hu PQ, Tuma-Warrino RJ, Bryan MA, Mitchell KG, Higgins DE, Watkins SC, Salter RD. Escherichia coli expressing recombinant antigen and listeriolysin O stimulate class I-restricted CD8+ T cells following uptake by human APC. Journal of Immunology (Baltimore, Md. : 1950). 172: 1595-601. PMID 14734740  1
2003 Gründling A, Gonzalez MD, Higgins DE. Requirement of the Listeria monocytogenes broad-range phospholipase PC-PLC during infection of human epithelial cells. Journal of Bacteriology. 185: 6295-307. PMID 14563864  0.44
2002 Dancz CE, Haraga A, Portnoy DA, Higgins DE. Inducible control of virulence gene expression in Listeria monocytogenes: temporal requirement of listeriolysin O during intracellular infection. Journal of Bacteriology. 184: 5935-45. PMID 12374827 DOI: 10.1128/JB.184.21.5935-5945.2002  1
2002 Parker JS, Broering TJ, Kim J, Higgins DE, Nibert ML. Reovirus core protein mu2 determines the filamentous morphology of viral inclusion bodies by interacting with and stabilizing microtubules. Journal of Virology. 76: 4483-96. PMID 11932414 DOI: 10.1128/JVI.76.9.4483-4496.2002  1
2000 Gedde MM, Higgins DE, Tilney LG, Portnoy DA. Role of listeriolysin O in cell-to-cell spread of Listeria monocytogenes. Infection and Immunity. 68: 999-1003. PMID 10639481 DOI: 10.1128/IAI.68.2.999-1003.2000  1
1999 Higgins DE, Shastri N, Portnoy DA. Delivery of protein to the cytosol of macrophages using Escherichia coli K-12 Molecular Microbiology. 31: 1631-1641. PMID 10209738  1
1998 Higgins DE, Portnoy DA. Bacterial delivery of DNA evolves Nature Biotechnology. 16: 138-139. PMID 9487514  1
1996 Higgins DE, Dirita VJ. Genetic analysis of the interaction between Vibrio cholerae transcription activator ToxR and toxT promoter DNA Journal of Bacteriology. 178: 1080-1087. PMID 8576041  1
1994 Higgins DE, DiRita VJ. Transcriptional control of toxT, a regulatory gene in the ToxR regulon of Vibrio cholerae Molecular Microbiology. 14: 17-29. PMID 7830555 DOI: 10.1111/j.1365-2958.1994.tb01263.x  1
1992 Higgins DE, Nazareno E, DiRita VJ. The virulence gene activator ToxT from Vibrio cholerae is a member of the AraC family of transcriptional activators Journal of Bacteriology. 174: 6974-6980. PMID 1400247  1
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