George A. O'Toole - Publications

Molecular Pathogenesis Dartmouth College, Hanover, NH, United States 
Microbiology Biology

135 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Orazi G, Jean-Pierre F, O'Toole GA. PA14 enhances the efficacy of norfloxacin against Newman biofilms. Journal of Bacteriology. PMID 32661077 DOI: 10.1128/JB.00159-20  0.32
2020 Lee CK, Vachier J, de Anda J, Zhao K, Baker AE, Bennett RR, Armbruster CR, Lewis KA, Tarnopol RL, Lomba CJ, Hogan DA, Parsek MR, O'Toole GA, Golestanian R, Wong GCL. Social Cooperativity of Bacteria during Reversible Surface Attachment in Young Biofilms: a Quantitative Comparison of Pseudomonas aeruginosa PA14 and PAO1. Mbio. 11. PMID 32098815 DOI: 10.1128/mBio.02644-19  0.32
2019 Orazi G, O'Toole GA. 'It takes a village': mechanisms underlying antimicrobial recalcitrance of polymicrobial biofilms. Journal of Bacteriology. PMID 31548277 DOI: 10.1128/JB.00530-19  0.32
2019 Orazi G, Ruoff KL, O'Toole GA. Pseudomonas aeruginosa Increases the Sensitivity of Biofilm-Grown Staphylococcus aureus to Membrane-Targeting Antiseptics and Antibiotics. Mbio. 10. PMID 31363032 DOI: 10.1128/mBio.01501-19  0.32
2019 Lewis KA, Baker AE, Chen AI, Harty CE, Kuchma SL, O'Toole GA, Hogan DA. Ethanol decreases flagellar motility through the regulation of flagellar stators. Journal of Bacteriology. PMID 31109994 DOI: 10.1128/JB.00285-19  0.52
2019 Henson MA, Orazi G, Phalak P, O'Toole GA. Metabolic Modeling of Cystic Fibrosis Airway Communities Predicts Mechanisms of Pathogen Dominance. Msystems. 4. PMID 31020043 DOI: 10.1128/mSystems.00026-19  0.32
2019 Scott JE, O'Toole GA. The Yin and Yang of Lung Infections in Cystic Fibrosis: A Model for Studying Polymicrobial Interactions. Journal of Bacteriology. PMID 30885933 DOI: 10.1128/JB.00115-19  0.32
2019 Scott JE, Li K, Filkins LM, Zhu B, Kuchma SL, Schwartzman JD, O'Toole GA. Can Inhibit Growth of Streptococcal Species via Siderophore Production. Journal of Bacteriology. PMID 30718303 DOI: 10.1128/JB.00014-19  0.52
2019 Baker AE, Webster SS, Diepold A, Kuchma SL, Bordeleau E, Armitage JP, O'Toole GA. Flagellar stators stimulate c-di-GMP production by . Journal of Bacteriology. PMID 30642992 DOI: 10.1128/JB.00741-18  0.52
2018 Lee CK, de Anda J, Baker AE, Bennett RR, Luo Y, Lee EY, Keefe JA, Helali JS, Ma J, Zhao K, Golestanian R, O'Toole GA, Wong GCL. Multigenerational memory and adaptive adhesion in early bacterial biofilm communities. Proceedings of the National Academy of Sciences of the United States of America. PMID 29559526 DOI: 10.1073/pnas.1720071115  0.32
2017 Koeva M, Gutu AD, Hebert W, Wager JD, Yonker LM, O'Toole GA, Ausubel FM, Moskowitz SM, Joseph-McCarthy D. An Anti-Persister Strategy for the Treatment of Chronic Pseudomonas aeruginosa Infections. Antimicrobial Agents and Chemotherapy. PMID 28923873 DOI: 10.1128/AAC.00987-17  0.48
2017 de Anda J, Lee EY, Lee CK, Bennett RR, Ji X, Soltani S, Harrison MC, Baker AE, Luo Y, Chou T, O'Toole GA, Armani AM, Golestanian R, Wong GCL. High-Speed "4D" Computational Microscopy of Bacterial Surface Motility. Acs Nano. PMID 28836761 DOI: 10.1021/acsnano.7b04738  0.32
2017 Orazi G, O'Toole GA. Pseudomonas aeruginosa Alters Staphylococcus aureus Sensitivity to Vancomycin in a Biofilm Model of Cystic Fibrosis Infection. Mbio. 8. PMID 28720732 DOI: 10.1128/mBio.00873-17  0.32
2017 Armitage JP, Becker A, Christie PJ, de Boer PAJ, DiRita VJ, Gourse RL, Henkin TM, Margolin W, Metcalf WW, Mullineaux CW, O'Toole GA, Parkinson JS, Schneewind O, Silhavy TJ, Stock AM, et al. Classic Spotlights: Selected Highlights from the First 100 Years of the Journal of Bacteriology. Journal of Bacteriology. 199. PMID 28611240 DOI: 10.1128/JB.00062-17  0.32
2017 Bernier SP, Hum C, Li X, O'Toole GA, Magarvey N, Surette MG. Pseudomonas aeruginosa-derived rhamnolipids and other detergents modulate colony morphotype and motility in the Burkholderia cepacia complex. Journal of Bacteriology. PMID 28439038 DOI: 10.1128/JB.00171-17  0.4
2017 Baker AE, O'Toole GA. Bacteria, Rev Your Engines: Stator Dynamics Regulate Flagellar Motility. Journal of Bacteriology. PMID 28320878 DOI: 10.1128/JB.00088-17  0.32
2017 Ribbe J, Baker AE, Euler S, O'Toole GA, Maier B. The role of cyclic di-GMP and exopolysaccharide in type IV pilus dynamics. Journal of Bacteriology. PMID 28167523 DOI: 10.1128/JB.00859-16  0.32
2016 Heussler GE, Miller JL, Price CE, Collins AJ, O'Toole GA. Requirements for Pseudomonas aeruginosa Type I-F CRISPR-Cas Adaptation Determined Using a Biofilm Enrichment Assay. Journal of Bacteriology. PMID 27573013 DOI: 10.1128/JB.00458-16  0.48
2016 Bernier SP, Workentine ML, Li X, Magarvey NA, O'Toole GA, Surette MG. Cyanide Toxicity to Burkholderia cenocepacia Is Modulated by Polymicrobial Communities and Environmental Factors. Frontiers in Microbiology. 7: 725. PMID 27242743 DOI: 10.3389/fmicb.2016.00725  1
2016 Baker AE, Diepold A, Kuchma SL, Scott JE, Ha DG, Orazi G, Armitage JP, O'Toole GA. A PilZ domain protein FlgZ mediates c-di-GMP-dependent swarming motility control in Pseudomonas aeruginosa. Journal of Bacteriology. PMID 27114465 DOI: 10.1128/JB.00196-16  1
2016 Heussler GE, O'Toole GA. Friendly Fire: Biological Functions and Consequences of Chromosomal-Targeting by CRISPR-Cas Systems. Journal of Bacteriology. PMID 26929301 DOI: 10.1128/JB.00086-16  0.48
2016 Bennett RR, Lee CK, De Anda J, Nealson KH, Yildiz FH, O'Toole GA, Wong GC, Golestanian R. Species-dependent hydrodynamics of flagellum-tethered bacteria in early biofilm development. Journal of the Royal Society, Interface / the Royal Society. 13. PMID 26864892 DOI: 10.1098/rsif.2015.0966  1
2016 O'Toole GA, Wong GCL. Sensational biofilms: Surface sensing in bacteria Current Opinion in Microbiology. 30: 139-146. DOI: 10.1016/j.mib.2016.02.004  1
2015 Price KE, Orazi G, Ruoff KL, Hebert WP, O'Toole GA, Mastoridis P. Mannitol Does Not Enhance Tobramycin Killing of Pseudomonas aeruginosa in a Cystic Fibrosis Model System of Biofilm Formation. Plos One. 10: e0141192. PMID 26506004 DOI: 10.1371/journal.pone.0141192  1
2015 Price KE, Naimie AA, Griffin EF, Bay C, O'Toole GA. Tobramycin Treated Pseudomonas aeruginosa PA14 Enhances Streptococcus constellatus 7155 Biofilm Formation in a Cystic Fibrosis Model System. Journal of Bacteriology. PMID 26483523 DOI: 10.1128/JB.00705-15  1
2015 Ha DG, O'Toole GA. c-di-GMP and its Effects on Biofilm Formation and Dispersion: a Pseudomonas Aeruginosa Review. Microbiology Spectrum. 3: MB-0003-2014. PMID 26104694 DOI: 10.1128/microbiolspec.MB-0003-2014  1
2015 Cooley RB, Smith TJ, Leung W, Tierney V, Borlee BR, O'Toole GA, Sondermann H. Cyclic di-GMP-regulated periplasmic proteolysis of a Pseudomonas aeruginosa type Vb secretion system substrate. Journal of Bacteriology. PMID 26100041 DOI: 10.1128/JB.00369-15  1
2015 Heussler GE, Cady KC, Koeppen K, Bhuju S, Stanton BA, O'Toole GA. Clustered Regularly Interspaced Short Palindromic Repeat-Dependent, Biofilm-Specific Death of Pseudomonas aeruginosa Mediated by Increased Expression of Phage-Related Genes. Mbio. 6: e00129-15. PMID 25968642 DOI: 10.1128/mBio.00129-15  0.72
2015 Filkins LM, Graber JA, Olson DG, Dolben EL, Lynd LR, Bhuju S, O'Toole GA. Coculture of Staphylococcus aureus with Pseudomonas aeruginosa Drives S. aureus towards Fermentative Metabolism and Reduced Viability in a Cystic Fibrosis Model. Journal of Bacteriology. 197: 2252-64. PMID 25917910 DOI: 10.1128/JB.00059-15  1
2015 Hoen AG, Li J, Moulton LA, O'Toole GA, Housman ML, Koestler DC, Guill MF, Moore JH, Hibberd PL, Morrison HG, Sogin ML, Karagas MR, Madan JC. Associations between Gut Microbial Colonization in Early Life and Respiratory Outcomes in Cystic Fibrosis. The Journal of Pediatrics. 167: 138-147.e3. PMID 25818499 DOI: 10.1016/j.jpeds.2015.02.049  1
2014 Willger SD, Grim SL, Dolben EL, Shipunova A, Hampton TH, Morrison HG, Filkins LM, O'Toole GA, Moulton LA, Ashare A, Sogin ML, Hogan DA. Characterization and quantification of the fungal microbiome in serial samples from individuals with cystic fibrosis. Microbiome. 2: 40. PMID 25408892 DOI: 10.1186/2049-2618-2-40  1
2014 Siryaporn A, Kuchma SL, O'Toole GA, Gitai Z. Surface attachment induces Pseudomonas aeruginosa virulence. Proceedings of the National Academy of Sciences of the United States of America. 111: 16860-5. PMID 25385640 DOI: 10.1073/pnas.1415712111  0.52
2014 Chen AI, Dolben EF, Okegbe C, Harty CE, Golub Y, Thao S, Ha DG, Willger SD, O'Toole GA, Harwood CS, Dietrich LE, Hogan DA. Candida albicans ethanol stimulates Pseudomonas aeruginosa WspR-controlled biofilm formation as part of a cyclic relationship involving phenazines. Plos Pathogens. 10: e1004480. PMID 25340349 DOI: 10.1371/journal.ppat.1004480  1
2014 Chatterjee D, Cooley RB, Boyd CD, Mehl RA, O'Toole GA, Sondermann H. Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP. Elife. 3: e03650. PMID 25182848 DOI: 10.7554/eLife.03650  0.84
2014 Ballok AE, Filkins LM, Bomberger JM, Stanton BA, O'Toole GA. Epoxide-mediated differential packaging of Cif and other virulence factors into outer membrane vesicles. Journal of Bacteriology. 196: 3633-42. PMID 25112474 DOI: 10.1128/JB.01760-14  0.44
2014 Hampton TH, Green DM, Cutting GR, Morrison HG, Sogin ML, Gifford AH, Stanton BA, O'Toole GA. The microbiome in pediatric cystic fibrosis patients: the role of shared environment suggests a window of intervention. Microbiome. 2: 14. PMID 25071935 DOI: 10.1186/2049-2618-2-14  1
2014 Celaj S, Gleeson MW, Deng J, O'Toole GA, Hampton TH, Toft MF, Morrison HG, Sogin ML, Putra J, Suriawinata AA, Gorham JD. The microbiota regulates susceptibility to Fas-mediated acute hepatic injury. Laboratory Investigation; a Journal of Technical Methods and Pathology. 94: 938-49. PMID 25068658 DOI: 10.1038/labinvest.2014.93  1
2014 Boyd CD, Smith TJ, El-Kirat-Chatel S, Newell PD, Dufrêne YF, O'Toole GA. Structural features of the Pseudomonas fluorescens biofilm adhesin LapA required for LapG-dependent cleavage, biofilm formation, and cell surface localization. Journal of Bacteriology. 196: 2775-88. PMID 24837291 DOI: 10.1128/JB.01629-14  0.84
2014 Ha DG, Kuchma SL, O'Toole GA. Plate-based assay for swarming motility in Pseudomonas aeruginosa. Methods in Molecular Biology (Clifton, N.J.). 1149: 67-72. PMID 24818898 DOI: 10.1007/978-1-4939-0473-0_8  0.96
2014 Ha DG, Kuchma SL, O'Toole GA. Plate-based assay for swimming motility in Pseudomonas aeruginosa. Methods in Molecular Biology (Clifton, N.J.). 1149: 59-65. PMID 24818897 DOI: 10.1007/978-1-4939-0473-0_7  0.96
2014 Ha DG, Richman ME, O'Toole GA. Deletion mutant library for investigation of functional outputs of cyclic diguanylate metabolism in Pseudomonas aeruginosa PA14. Applied and Environmental Microbiology. 80: 3384-93. PMID 24657857 DOI: 10.1128/AEM.00299-14  0.96
2014 El-Kirat-Chatel S, Beaussart A, Boyd CD, O'Toole GA, Dufreîne YF. Single-cell and single-molecule analysis deciphers the localization, adhesion, and mechanics of the biofilm adhesin LapA Acs Chemical Biology. 9: 485-494. PMID 24556201 DOI: 10.1021/cb400794e  1
2014 Lovewell RR, Hayes SM, O'Toole GA, Berwin B. Pseudomonas aeruginosa flagellar motility activates the phagocyte PI3K/Akt pathway to induce phagocytic engulfment. American Journal of Physiology. Lung Cellular and Molecular Physiology. 306: L698-707. PMID 24487390 DOI: 10.1152/ajplung.00319.2013  1
2014 Bahl CD, Hvorecny KL, Bridges AA, Ballok AE, Bomberger JM, Cady KC, O'Toole GA, Madden DR. Signature motifs identify an Acinetobacter Cif virulence factor with epoxide hydrolase activity. The Journal of Biological Chemistry. 289: 7460-9. PMID 24474692 DOI: 10.1074/jbc.M113.518092  1
2014 El-Kirat-Chatel S, Boyd CD, O'Toole GA, Dufreîne YF. Single-molecule analysis of pseudomonas fluorescens footprints Acs Nano. 8: 1690-1698. PMID 24456070 DOI: 10.1021/nn4060489  1
2014 Musafer HK, Kuchma SL, Naimie AA, Schwartzman JD, Al-Mathkhury HJ, O'Toole GA. Investigating the link between imipenem resistance and biofilm formation by Pseudomonas aeruginosa. Microbial Ecology. 68: 111-20. PMID 24435545 DOI: 10.1007/s00248-013-0361-6  0.52
2014 Dane EL, Ballok AE, O'Toole GA, Grinstaff MW. Synthesis of Bioinspired Carbohydrate Amphiphiles that Promote and Inhibit Biofilms. Chemical Science (Royal Society of Chemistry : 2010). 5. PMID 24376911 DOI: 10.1039/C3SC52777H  1
2014 Gifford AH, Alexandru DM, Li Z, Dorman DB, Moulton LA, Price KE, Hampton TH, Sogin ML, Zuckerman JB, Parker HW, Stanton BA, O'Toole GA. Iron supplementation does not worsen respiratory health or alter the sputum microbiome in cystic fibrosis. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 13: 311-8. PMID 24332997 DOI: 10.1016/j.jcf.2013.11.004  1
2014 Schwartz M, Ivanov I, Boyd CD, Gaddis R, O'Connor S, Burnham NA, O'Toole GA, Camesano TA. Probing large protein adhesin molecules on Pseudomonas fluorescens with atomic force microscopy Journal of Bionanoscience. 8: 455-461. DOI: 10.1166/jbns.2014.1269  1
2014 Siryaporn A, Kuchma SL, O'Toole GA, Gitai Z, Ausubel FM. Surface attachment induces Pseudomonas aeruginosa virulence Proceedings of the National Academy of Sciences of the United States of America. 111: 16860-16865. DOI: 10.1073/pnas.1415712111  1
2013 Price KE, Hampton TH, Gifford AH, Dolben EL, Hogan DA, Morrison HG, Sogin ML, O'Toole GA. Unique microbial communities persist in individual cystic fibrosis patients throughout a clinical exacerbation. Microbiome. 1: 27. PMID 24451123 DOI: 10.1186/2049-2618-1-27  1
2013 Ballok AE, O'Toole GA. Pouring salt on a wound: Pseudomonas aeruginosa virulence factors alter Na+ and Cl- flux in the lung. Journal of Bacteriology. 195: 4013-9. PMID 23836869 DOI: 10.1128/JB.00339-13  0.36
2013 Anderson GG, Kenney TF, Macleod DL, Henig NR, O'Toole GA. Eradication of Pseudomonas aeruginosa biofilms on cultured airway cells by a fosfomycin/tobramycin antibiotic combination. Pathogens and Disease. 67: 39-45. PMID 23620118 DOI: 10.1111/2049-632X.12015  1
2013 Sisti F, Ha DG, O'Toole GA, Hozbor D, Fernández J. Cyclic-di-GMP signalling regulates motility and biofilm formation in Bordetella bronchiseptica. Microbiology (Reading, England). 159: 869-79. PMID 23475948 DOI: 10.1099/mic.0.064345-0  1
2012 Ivanov IE, Boyd CD, Newell PD, Schwartz ME, Turnbull L, Johnson MS, Whitchurch CB, O'Toole GA, Camesano TA. Atomic force and super-resolution microscopy support a role for LapA as a cell-surface biofilm adhesin of Pseudomonas fluorescens. Research in Microbiology. 163: 685-91. PMID 23064158 DOI: 10.1016/j.resmic.2012.10.001  1
2012 Boyd CD, O'Toole GA. Second messenger regulation of biofilm formation: breakthroughs in understanding c-di-GMP effector systems. Annual Review of Cell and Developmental Biology. 28: 439-62. PMID 23057745 DOI: 10.1146/annurev-cellbio-101011-155705  1
2012 Madan JC, Koestler DC, Stanton BA, Davidson L, Moulton LA, Housman ML, Moore JH, Guill MF, Morrison HG, Sogin ML, Hampton TH, Karagas MR, Palumbo PE, Foster JA, Hibberd PL, et al. Serial analysis of the gut and respiratory microbiome in cystic fibrosis in infancy: interaction between intestinal and respiratory tracts and impact of nutritional exposures. Mbio. 3. PMID 22911969 DOI: 10.1128/mBio.00251-12  1
2012 Cady KC, Bondy-Denomy J, Heussler GE, Davidson AR, O'Toole GA. The CRISPR/Cas adaptive immune system of Pseudomonas aeruginosa mediates resistance to naturally occurring and engineered phages. Journal of Bacteriology. 194: 5728-38. PMID 22885297 DOI: 10.1128/JB.01184-12  1
2012 Gifford AH, Moulton LA, Dorman DB, Olbina G, Westerman M, Parker HW, Stanton BA, O'Toole GA. Iron homeostasis during cystic fibrosis pulmonary exacerbation. Clinical and Translational Science. 5: 368-73. PMID 22883617 DOI: 10.1111/j.1752-8062.2012.00417.x  1
2012 Kuchma SL, Griffin EF, O'Toole GA. Minor pilins of the type IV pilus system participate in the negative regulation of swarming motility. Journal of Bacteriology. 194: 5388-403. PMID 22865844 DOI: 10.1128/JB.00899-12  1
2012 Ballok AE, Bahl CD, Dolben EL, Lindsay AK, St Laurent JD, Hogan DA, Madden DR, O'Toole GA. Epoxide-mediated CifR repression of cif gene expression utilizes two binding sites in Pseudomonas aeruginosa. Journal of Bacteriology. 194: 5315-24. PMID 22843844 DOI: 10.1128/JB.00984-12  1
2012 Yu Q, Griffin EF, Moreau-Marquis S, Schwartzman JD, Stanton BA, O'Toole GA. In vitro evaluation of tobramycin and aztreonam versus Pseudomonas aeruginosa biofilms on cystic fibrosis-derived human airway epithelial cells. The Journal of Antimicrobial Chemotherapy. 67: 2673-81. PMID 22843834 DOI: 10.1093/jac/dks296  1
2012 Hampton TH, Ballok AE, Bomberger JM, Rutkowski MR, Barnaby R, Coutermarsh B, Conejo-Garcia JR, O'Toole GA, Stanton BA. Does the F508-CFTR mutation induce a proinflammatory response in human airway epithelial cells? American Journal of Physiology. Lung Cellular and Molecular Physiology. 303: L509-18. PMID 22821996 DOI: 10.1152/ajplung.00226.2011  0.44
2012 Filkins LM, Hampton TH, Gifford AH, Gross MJ, Hogan DA, Sogin ML, Morrison HG, Paster BJ, O'Toole GA. Prevalence of streptococci and increased polymicrobial diversity associated with cystic fibrosis patient stability. Journal of Bacteriology. 194: 4709-17. PMID 22753064 DOI: 10.1128/JB.00566-12  1
2012 Boyd CD, Chatterjee D, Sondermann H, O'Toole GA. LapG, required for modulating biofilm formation by Pseudomonas fluorescens Pf0-1, is a calcium-dependent protease. Journal of Bacteriology. 194: 4406-14. PMID 22707708 DOI: 10.1128/JB.00642-12  1
2012 Chatterjee D, Boyd CD, O'Toole GA, Sondermann H. Structural characterization of a conserved, calcium-dependent periplasmic protease from Legionella pneumophila. Journal of Bacteriology. 194: 4415-25. PMID 22707706 DOI: 10.1128/JB.00640-12  1
2012 Madan JC, Salari RC, Saxena D, Davidson L, O'Toole GA, Moore JH, Sogin ML, Foster JA, Edwards WH, Palumbo P, Hibberd PL. Gut microbial colonisation in premature neonates predicts neonatal sepsis. Archives of Disease in Childhood. Fetal and Neonatal Edition. 97: F456-62. PMID 22562869 DOI: 10.1136/fetalneonatal-2011-301373  1
2012 O'Toole GA, Wathier M, Zegans ME, Shanks RM, Kowalski R, Grinstaff MW. Diphosphonium ionic liquids as broad-spectrum antimicrobial agents. Cornea. 31: 810-6. PMID 22236790 DOI: 10.1097/ICO.0b013e31823f0a86  1
2012 Twomey KB, O'Connell OJ, McCarthy Y, Dow JM, O'Toole GA, Plant BJ, Ryan RP. Bacterial cis-2-unsaturated fatty acids found in the cystic fibrosis airway modulate virulence and persistence of Pseudomonas aeruginosa. The Isme Journal. 6: 939-50. PMID 22134647 DOI: 10.1038/ismej.2011.167  1
2012 Mintzer MA, Dane EL, O'Toole GA, Grinstaff MW. Exploiting dendrimer multivalency to combat emerging and re-emerging infectious diseases. Molecular Pharmaceutics. 9: 342-54. PMID 22126461 DOI: 10.1021/mp2005033  1
2011 Ha DG, Merritt JH, Hampton TH, Hodgkinson JT, Janecek M, Spring DR, Welch M, O'Toole GA. 2-Heptyl-4-quinolone, a precursor of the Pseudomonas quinolone signal molecule, modulates swarming motility in Pseudomonas aeruginosa. Journal of Bacteriology. 193: 6770-80. PMID 21965567 DOI: 10.1128/JB.05929-11  0.44
2011 Lovewell RR, Collins RM, Acker JL, O'Toole GA, Wargo MJ, Berwin B. Step-wise loss of bacterial flagellar torsion confers progressive phagocytic evasion. Plos Pathogens. 7: e1002253. PMID 21949654 DOI: 10.1371/journal.ppat.1002253  1
2011 Newell PD, Yoshioka S, Hvorecny KL, Monds RD, O'Toole GA. Systematic analysis of diguanylate cyclases that promote biofilm formation by Pseudomonas fluorescens Pf0-1. Journal of Bacteriology. 193: 4685-98. PMID 21764921 DOI: 10.1128/JB.05483-11  1
2011 Bernier SP, Ha DG, Khan W, Merritt JH, O'Toole GA. Modulation of Pseudomonas aeruginosa surface-associated group behaviors by individual amino acids through c-di-GMP signaling. Research in Microbiology. 162: 680-8. PMID 21554951 DOI: 10.1016/j.resmic.2011.04.014  1
2011 Bomberger JM, Ye S, Maceachran DP, Koeppen K, Barnaby RL, O'Toole GA, Stanton BA. A Pseudomonas aeruginosa toxin that hijacks the host ubiquitin proteolytic system. Plos Pathogens. 7: e1001325. PMID 21455491 DOI: 10.1371/journal.ppat.1001325  0.64
2011 Cady KC, O'Toole GA. Non-identity-mediated CRISPR-bacteriophage interaction mediated via the Csy and Cas3 proteins. Journal of Bacteriology. 193: 3433-45. PMID 21398535 DOI: 10.1128/JB.01411-10  0.72
2011 Navarro MV, Newell PD, Krasteva PV, Chatterjee D, Madden DR, O'Toole GA, Sondermann H. Structural basis for c-di-GMP-mediated inside-out signaling controlling periplasmic proteolysis. Plos Biology. 9: e1000588. PMID 21304926 DOI: 10.1371/journal.pbio.1000588  0.72
2011 Newell PD, Boyd CD, Sondermann H, O'Toole GA. A c-di-GMP effector system controls cell adhesion by inside-out signaling and surface protein cleavage. Plos Biology. 9: e1000587. PMID 21304920 DOI: 10.1371/journal.pbio.1000587  0.84
2011 Cady KC, White AS, Hammond JH, Abendroth MD, Karthikeyan RS, Lalitha P, Zegans ME, O'Toole GA. Prevalence, conservation and functional analysis of Yersinia and Escherichia CRISPR regions in clinical Pseudomonas aeruginosa isolates. Microbiology (Reading, England). 157: 430-7. PMID 21081758 DOI: 10.1099/mic.0.045732-0  1
2010 Khan W, Bernier SP, Kuchma SL, Hammond JH, Hasan F, O'Toole GA. Aminoglycoside resistance of Pseudomonas aeruginosa biofilms modulated by extracellular polysaccharide. International Microbiology : the Official Journal of the Spanish Society For Microbiology. 13: 207-12. PMID 21404215  0.56
2010 Merritt JH, Ha DG, Cowles KN, Lu W, Morales DK, Rabinowitz J, Gitai Z, O'Toole GA. Specific control of Pseudomonas aeruginosa surface-associated behaviors by two c-di-GMP diguanylate cyclases. Mbio. 1. PMID 20978535 DOI: 10.1128/mBio.00183-10  0.32
2010 Khoo X, O'Toole GA, Nair SA, Snyder BD, Kenan DJ, Grinstaff MW. Staphylococcus aureus resistance on titanium coated with multivalent PEGylated-peptides. Biomaterials. 31: 9285-92. PMID 20863561 DOI: 10.1016/j.biomaterials.2010.08.031  1
2010 Amiel E, Lovewell RR, O'Toole GA, Hogan DA, Berwin B. Pseudomonas aeruginosa evasion of phagocytosis is mediated by loss of swimming motility and is independent of flagellum expression. Infection and Immunity. 78: 2937-45. PMID 20457788 DOI: 10.1128/IAI.00144-10  1
2010 Monds RD, Newell PD, Wagner JC, Schwartzman JA, Lu W, Rabinowitz JD, O'Toole GA. Di-adenosine tetraphosphate (Ap4A) metabolism impacts biofilm formation by Pseudomonas fluorescens via modulation of c-di-GMP-dependent pathways. Journal of Bacteriology. 192: 3011-23. PMID 20154123 DOI: 10.1128/JB.01571-09  1
2010 Bahl CD, Morisseau C, Bomberger JM, Stanton BA, Hammock BD, O'Toole GA, Madden DR. Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor. Journal of Bacteriology. 192: 1785-95. PMID 20118260 DOI: 10.1128/JB.01348-09  1
2010 Bahl CD, MacEachran DP, O'Toole GA, Madden DR. Purification, crystallization and preliminary X-ray diffraction analysis of Cif, a virulence factor secreted by Pseudomonas aeruginosa. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 26-8. PMID 20057063 DOI: 10.1107/S1744309109047599  0.64
2010 Anderson GG, Yahr TL, Lovewell RR, O'Toole GA. The Pseudomonas aeruginosa magnesium transporter MgtE inhibits transcription of the type III secretion system. Infection and Immunity. 78: 1239-49. PMID 20028803 DOI: 10.1128/IAI.00865-09  1
2009 Leid JG, Kerr M, Selgado C, Johnson C, Moreno G, Smith A, Shirtliff ME, O'Toole GA, Cope EK. Flagellum-mediated biofilm defense mechanisms of Pseudomonas aeruginosa against host-derived lactoferrin. Infection and Immunity. 77: 4559-66. PMID 19651866 DOI: 10.1128/IAI.00075-09  1
2009 Khoo X, Hamilton P, O'Toole GA, Snyder BD, Kenan DJ, Grinstaff MW. Directed assembly of PEGylated-peptide coatings for infection-resistant titanium metal. Journal of the American Chemical Society. 131: 10992-7. PMID 19621876 DOI: 10.1021/ja9020827  1
2009 Shanks RM, Kadouri DE, MacEachran DP, O'Toole GA. New yeast recombineering tools for bacteria. Plasmid. 62: 88-97. PMID 19477196 DOI: 10.1016/j.plasmid.2009.05.002  1
2009 Bomberger JM, Maceachran DP, Coutermarsh BA, Ye S, O'Toole GA, Stanton BA. Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. Plos Pathogens. 5: e1000382. PMID 19360133 DOI: 10.1371/journal.ppat.1000382  1
2009 Newell PD, Monds RD, O'Toole GA. LapD is a bis-(3',5')-cyclic dimeric GMP-binding protein that regulates surface attachment by Pseudomonas fluorescens Pf0-1. Proceedings of the National Academy of Sciences of the United States of America. 106: 3461-6. PMID 19218451 DOI: 10.1073/pnas.0808933106  1
2009 Moreau-Marquis S, O'Toole GA, Stanton BA. Tobramycin and FDA-approved iron chelators eliminate Pseudomonas aeruginosa biofilms on cystic fibrosis cells. American Journal of Respiratory Cell and Molecular Biology. 41: 305-13. PMID 19168700 DOI: 10.1165/rcmb.2008-0299OC  0.44
2009 Monds RD, O'Toole GA. The developmental model of microbial biofilms: ten years of a paradigm up for review. Trends in Microbiology. 17: 73-87. PMID 19162483 DOI: 10.1016/j.tim.2008.11.001  1
2009 Zegans ME, Wagner JC, Cady KC, Murphy DM, Hammond JH, O'Toole GA. Interaction between bacteriophage DMS3 and host CRISPR region inhibits group behaviors of Pseudomonas aeruginosa. Journal of Bacteriology. 191: 210-9. PMID 18952788 DOI: 10.1128/JB.00797-08  1
2008 Ye S, MacEachran DP, Hamilton JW, O'Toole GA, Stanton BA. Chemotoxicity of doxorubicin and surface expression of P-glycoprotein (MDR1) is regulated by the Pseudomonas aeruginosa toxin Cif. American Journal of Physiology. Cell Physiology. 295: C807-18. PMID 18650266 DOI: 10.1152/ajpcell.00234.2008  1
2008 MacEachran DP, Stanton BA, O'Toole GA. Cif is negatively regulated by the TetR family repressor CifR. Infection and Immunity. 76: 3197-206. PMID 18458065 DOI: 10.1128/IAI.00305-08  1
2008 Anderson GG, O'Toole GA. Innate and induced resistance mechanisms of bacterial biofilms. Current Topics in Microbiology and Immunology. 322: 85-105. PMID 18453273 DOI: 10.1007/978-3-540-75418-3_5  1
2008 Moreau-Marquis S, Bomberger JM, Anderson GG, Swiatecka-Urban A, Ye S, O'Toole GA, Stanton BA. The DeltaF508-CFTR mutation results in increased biofilm formation by Pseudomonas aeruginosa by increasing iron availability. American Journal of Physiology. Lung Cellular and Molecular Physiology. 295: L25-37. PMID 18359885 DOI: 10.1152/ajplung.00391.2007  1
2008 Shanks RM, Meehl MA, Brothers KM, Martinez RM, Donegan NP, Graber ML, Cheung AL, O'Toole GA. Genetic evidence for an alternative citrate-dependent biofilm formation pathway in Staphylococcus aureus that is dependent on fibronectin binding proteins and the GraRS two-component regulatory system. Infection and Immunity. 76: 2469-77. PMID 18347039 DOI: 10.1128/IAI.01370-07  0.64
2008 Moreau-Marquis S, Stanton BA, O'Toole GA. Pseudomonas aeruginosa biofilm formation in the cystic fibrosis airway. Pulmonary Pharmacology & Therapeutics. 21: 595-9. PMID 18234534 DOI: 10.1016/j.pupt.2007.12.001  0.44
2008 Anderson GG, Moreau-Marquis S, Stanton BA, O'Toole GA. In vitro analysis of tobramycin-treated Pseudomonas aeruginosa biofilms on cystic fibrosis-derived airway epithelial cells. Infection and Immunity. 76: 1423-33. PMID 18212077 DOI: 10.1128/IAI.01373-07  1
2008 Kukavica-Ibrulj I, Bragonzi A, Paroni M, Winstanley C, Sanschagrin F, O'Toole GA, Levesque RC. In vivo growth of Pseudomonas aeruginosa strains PAO1 and PA14 and the hypervirulent strain LESB58 in a rat model of chronic lung infection. Journal of Bacteriology. 190: 2804-13. PMID 18083816 DOI: 10.1128/JB.01572-07  1
2007 Zhang S, McCormack FX, Levesque RC, O'Toole GA, Lau GW. The flagellum of Pseudomonas aeruginosa is required for resistance to clearance by surfactant protein A. Plos One. 2: e564. PMID 17593964 DOI: 10.1371/journal.pone.0000564  1
2007 Merritt JH, Brothers KM, Kuchma SL, O'Toole GA. SadC reciprocally influences biofilm formation and swarming motility via modulation of exopolysaccharide production and flagellar function. Journal of Bacteriology. 189: 8154-64. PMID 17586642 DOI: 10.1128/JB.00585-07  1
2007 Kuchma SL, Brothers KM, Merritt JH, Liberati NT, Ausubel FM, O'Toole GA. BifA, a cyclic-Di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa PA14. Journal of Bacteriology. 189: 8165-78. PMID 17586641 DOI: 10.1128/JB.00586-07  1
2007 Toutain CM, Caizza NC, Zegans ME, O'Toole GA. Roles for flagellar stators in biofilm formation by Pseudomonas aeruginosa. Research in Microbiology. 158: 471-7. PMID 17533122 DOI: 10.1016/j.resmic.2007.04.001  0.56
2007 MacEachran DP, Ye S, Bomberger JM, Hogan DA, Swiatecka-Urban A, Stanton BA, O'Toole GA. The Pseudomonas aeruginosa secreted protein PA2934 decreases apical membrane expression of the cystic fibrosis transmembrane conductance regulator. Infection and Immunity. 75: 3902-12. PMID 17502391 DOI: 10.1128/IAI.00338-07  1
2007 Caiazza NC, Merritt JH, Brothers KM, O'Toole GA. Inverse regulation of biofilm formation and swarming motility by Pseudomonas aeruginosa PA14. Journal of Bacteriology. 189: 3603-12. PMID 17337585 DOI: 10.1128/JB.01685-06  1
2007 Monds RD, Newell PD, Gross RH, O'Toole GA. Phosphate-dependent modulation of c-di-GMP levels regulates Pseudomonas fluorescens Pf0-1 biofilm formation by controlling secretion of the adhesin LapA. Molecular Microbiology. 63: 656-79. PMID 17302799 DOI: 10.1111/j.1365-2958.2006.05539.x  1
2006 Kenan DJ, Walsh EB, Meyers SR, O'Toole GA, Carruthers EG, Lee WK, Zauscher S, Prata CA, Grinstaff MW. Peptide-PEG amphiphiles as cytophobic coatings for mammalian and bacterial cells. Chemistry & Biology. 13: 695-700. PMID 16873017 DOI: 10.1016/j.chembiol.2006.06.013  1
2006 Shanks RM, Caiazza NC, Hinsa SM, Toutain CM, O'Toole GA. Saccharomyces cerevisiae-based molecular tool kit for manipulation of genes from gram-negative bacteria. Applied and Environmental Microbiology. 72: 5027-36. PMID 16820502 DOI: 10.1128/AEM.00682-06  1
2006 Hinsa SM, O'Toole GA. Biofilm formation by Pseudomonas fluorescens WCS365: a role for LapD. Microbiology (Reading, England). 152: 1375-83. PMID 16622054 DOI: 10.1099/mic.0.28696-0  0.36
2006 Monds RD, Newell PD, Schwartzman JA, O'Toole GA. Conservation of the Pho regulon in Pseudomonas fluorescens Pf0-1. Applied and Environmental Microbiology. 72: 1910-24. PMID 16517638 DOI: 10.1128/AEM.72.3.1910-1924.2006  1
2006 Swiatecka-Urban A, Moreau-Marquis S, Maceachran DP, Connolly JP, Stanton CR, Su JR, Barnaby R, O'toole GA, Stanton BA. Pseudomonas aeruginosa inhibits endocytic recycling of CFTR in polarized human airway epithelial cells. American Journal of Physiology. Cell Physiology. 290: C862-72. PMID 16236828 DOI: 10.1152/ajpcell.00108.2005  0.64
2005 Merritt JH, Kadouri DE, O'Toole GA. Growing and analyzing static biofilms. Current Protocols in Microbiology. Unit 1B.1. PMID 18770545 DOI: 10.1002/9780471729259.mc01b01s00  1
2005 Zegans ME, Shanks RM, O'Toole GA. Bacterial biofilms and ocular infections. The Ocular Surface. 3: 73-80. PMID 17131010  0.56
2005 O'Toole GA, Stewart PS. Biofilms strike back. Nature Biotechnology. 23: 1378-9. PMID 16273068 DOI: 10.1038/nbt1105-1378  1
2005 Caiazza NC, Shanks RM, O'Toole GA. Rhamnolipids modulate swarming motility patterns of Pseudomonas aeruginosa. Journal of Bacteriology. 187: 7351-61. PMID 16237018 DOI: 10.1128/JB.187.21.7351-7361.2005  1
2005 Irie Y, O'toole GA, Yuk MH. Pseudomonas aeruginosa rhamnolipids disperse Bordetella bronchiseptica biofilms. Fems Microbiology Letters. 250: 237-43. PMID 16098688 DOI: 10.1016/j.femsle.2005.07.012  1
2005 Shanks RM, Donegan NP, Graber ML, Buckingham SE, Zegans ME, Cheung AL, O'Toole GA. Heparin stimulates Staphylococcus aureus biofilm formation. Infection and Immunity. 73: 4596-606. PMID 16040971 DOI: 10.1128/IAI.73.8.4596-4606.2005  1
2005 Kuchma SL, Connolly JP, O'Toole GA. A three-component regulatory system regulates biofilm maturation and type III secretion in Pseudomonas aeruginosa. Journal of Bacteriology. 187: 1441-54. PMID 15687209 DOI: 10.1128/JB.187.4.1441-1454.2005  0.52
2005 Toutain CM, Zegans ME, O'Toole GA. Evidence for two flagellar stators and their role in the motility of Pseudomonas aeruginosa. Journal of Bacteriology. 187: 771-7. PMID 15629949 DOI: 10.1128/JB.187.2.771-777.2005  0.56
2004 Sturgill G, Toutain CM, Komperda J, O'Toole GA, Rather PN. Role of CysE in production of an extracellular signaling molecule in Providencia stuartii and Escherichia coli: loss of CysE enhances biofilm formation in Escherichia coli. Journal of Bacteriology. 186: 7610-7. PMID 15516574 DOI: 10.1128/JB.186.22.7610-7617.2004  1
2004 Caiazza NC, O'Toole GA. SadB is required for the transition from reversible to irreversible attachment during biofilm formation by Pseudomonas aeruginosa PA14. Journal of Bacteriology. 186: 4476-85. PMID 15231779 DOI: 10.1128/JB.186.14.4476-4485.2004  1
2003 Mah TF, Pitts B, Pellock B, Walker GC, Stewart PS, O'Toole GA. A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance. Nature. 426: 306-10. PMID 14628055 DOI: 10.1038/nature02122  1
2003 Hinsa SM, Espinosa-Urgel M, Ramos JL, O'Toole GA. Transition from reversible to irreversible attachment during biofilm formation by Pseudomonas fluorescens WCS365 requires an ABC transporter and a large secreted protein. Molecular Microbiology. 49: 905-18. PMID 12890017  0.36
2003 Wozniak DJ, Wyckoff TJ, Starkey M, Keyser R, Azadi P, O'Toole GA, Parsek MR. Alginate is not a significant component of the extracellular polysaccharide matrix of PA14 and PAO1 Pseudomonas aeruginosa biofilms. Proceedings of the National Academy of Sciences of the United States of America. 100: 7907-12. PMID 12810959 DOI: 10.1073/pnas.1231792100  1
2003 Caiazza NC, O'Toole GA. Alpha-toxin is required for biofilm formation by Staphylococcus aureus. Journal of Bacteriology. 185: 3214-7. PMID 12730182 DOI: 10.1128/JB.185.10.3214-3217.2003  1
2003 Davey ME, Caiazza NC, O'Toole GA. Rhamnolipid surfactant production affects biofilm architecture in Pseudomonas aeruginosa PAO1. Journal of Bacteriology. 185: 1027-36. PMID 12533479 DOI: 10.1128/JB.185.3.1027-1036.2003  1
2000 O'Toole GA, Gibbs KA, Hager PW, Phibbs PV, Kolter R. The global carbon metabolism regulator Crc is a component of a signal transduction pathway required for biofilm development by Pseudomonas aeruginosa Journal of Bacteriology. 182: 425-431. PMID 10629189 DOI: 10.1128/JB.182.2.425-431.2000  1
1999 O'Toole GA, Pratt LA, Watnick PI, Newman DK, Weaver VB, Kolter R. Genetic approaches to study of biofilms. Methods in Enzymology. 310: 91-109. PMID 10547784 DOI: 10.1016/S0076-6879(99)10008-9  1
1998 O'Toole GA, Kolter R. Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development Molecular Microbiology. 30: 295-304. PMID 9791175 DOI: 10.1046/j.1365-2958.1998.01062.x  1
1998 O'Toole GA, Kolter R. Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: A genetic analysis Molecular Microbiology. 28: 449-461. PMID 9632250 DOI: 10.1046/j.1365-2958.1998.00797.x  1
1997 Bloemberg GV, O'Toole GA, Lugtenberg BJ, Kolter R. Green fluorescent protein as a marker for Pseudomonas spp. Applied and Environmental Microbiology. 63: 4543-51. PMID 9361441  1
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