Samuel M. Behar - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Immunology, Microbiology Biology

72 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wong EB, Gold MC, Meermeier EW, Xulu BZ, Khuzwayo S, Sullivan ZA, Mahyari E, Rogers Z, Kløverpris H, Sharma PK, Worley AH, Lalloo U, Baijnath P, Ambaram A, Naidoo L, ... ... Behar SM, et al. TRAV1-2 CD8 T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis. Communications Biology. 2: 203. PMID 31231693 DOI: 10.1038/s42003-019-0442-2  0.36
2018 Yang JD, Mott D, Sutiwisesak R, Lu YJ, Raso F, Stowell B, Babunovic GH, Lee J, Carpenter SM, Way SS, Fortune SM, Behar SM. Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages. Plos Pathogens. 14: e1007060. PMID 29782535 DOI: 10.1371/journal.ppat.1007060  0.6
2018 Carpenter SM, Behar SM. A new vaccine for tuberculosis in rhesus macaques. Nature Medicine. 24: 124-126. PMID 29414932 DOI: 10.1038/nm.4488  0.56
2017 Carpenter SM, Yang JD, Lee J, Barreira-Silva P, Behar SM. Vaccine-elicited memory CD4+ T cell expansion is impaired in the lungs during tuberculosis. Plos Pathogens. 13: e1006704. PMID 29176787 DOI: 10.1371/journal.ppat.1006704  0.56
2017 Rothchild AC, Stowell B, Goyal G, Nunes-Alves C, Yang Q, Papavinasasundaram K, Sassetti CM, Dranoff G, Chen X, Lee J, Behar SM. Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection. Mbio. 8. PMID 29066547 DOI: 10.1128/mBio.01514-17  0.6
2016 Booty MG, Barreira-Silva P, Carpenter SM, Nunes-Alves C, Jacques MK, Stowell BL, Jayaraman P, Beamer G, Behar SM. IL-21 signaling is essential for optimal host resistance against Mycobacterium tuberculosis infection. Scientific Reports. 6: 36720. PMID 27819295 DOI: 10.1038/srep36720  0.6
2016 Smith CM, Proulx MK, Olive AJ, Laddy D, Mishra BB, Moss C, Gutierrez NM, Bellerose MM, Barreira-Silva P, Phuah JY, Baker RE, Behar SM, Kornfeld H, Evans TG, Beamer G, et al. Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype. Mbio. 7. PMID 27651361 DOI: 10.1128/mBio.01516-16  0.48
2016 Marakalala MJ, Raju RM, Sharma K, Zhang YJ, Eugenin EA, Prideaux B, Daudelin IB, Chen PY, Booty MG, Kim JH, Eum SY, Via LE, Behar SM, Barry CE, Mann M, et al. Inflammatory signaling in human tuberculosis granulomas is spatially organized. Nature Medicine. PMID 27043495 DOI: 10.1038/nm.4073  0.64
2016 Jayaraman P, Jacques MK, Zhu C, Steblenko KM, Stowell BL, Madi A, Anderson AC, Kuchroo VK, Behar SM. TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection. Plos Pathogens. 12: e1005490. PMID 26967901 DOI: 10.1371/journal.ppat.1005490  0.64
2016 Booty MG, Nunes-Alves C, Carpenter SM, Jayaraman P, Behar SM. Multiple Inflammatory Cytokines Converge To Regulate CD8+ T Cell Expansion and Function during Tuberculosis. Journal of Immunology (Baltimore, Md. : 1950). 196: 1822-31. PMID 26755819 DOI: 10.4049/jimmunol.1502206  0.64
2016 Carpenter SM, Nunes-Alves C, Booty MG, Way SS, Behar SM. A Higher Activation Threshold of Memory CD8+ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis. Plos Pathogens. 12: e1005380. PMID 26745507 DOI: 10.1371/journal.ppat.1005380  0.6
2015 Behar SM, Baehrecke EH. Tuberculosis: Autophagy is not the answer. Nature. PMID 26649822 DOI: 10.1038/nature16324  0.64
2015 Nunes-Alves C, Booty MG, Carpenter SM, Rothchild AC, Martin CJ, Desjardins D, Steblenko K, Kløverpris HN, Madansein R, Ramsuran D, Leslie A, Correia-Neves M, Behar SM. Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection. Plos Pathogens. 11: e1004849. PMID 25945999 DOI: 10.1371/journal.ppat.1004849  0.64
2014 Behar SM, Carpenter SM, Booty MG, Barber DL, Jayaraman P. Orchestration of pulmonary T cell immunity during Mycobacterium tuberculosis infection: immunity interruptus. Seminars in Immunology. 26: 559-77. PMID 25311810 DOI: 10.1016/j.smim.2014.09.003  0.64
2014 Martinez N, Vallerskog T, West K, Nunes-Alves C, Lee J, Martens GW, Behar SM, Kornfeld H. Chromatin decondensation and T cell hyperresponsiveness in diabetes-associated hyperglycemia. Journal of Immunology (Baltimore, Md. : 1950). 193: 4457-68. PMID 25246495 DOI: 10.4049/jimmunol.1401125  0.64
2014 Behar SM, Sassetti CM. Immunology: Fixing the odds against tuberculosis. Nature. 511: 39-40. PMID 24990740 DOI: 10.1038/nature13512  0.64
2014 Nunes-Alves C, Booty MG, Carpenter SM, Jayaraman P, Rothchild AC, Behar SM. In search of a new paradigm for protective immunity to TB. Nature Reviews. Microbiology. 12: 289-99. PMID 24590243 DOI: 10.1038/nrmicro3230  0.64
2014 Martin CJ, Peters KN, Behar SM. Macrophages clean up: efferocytosis and microbial control. Current Opinion in Microbiology. 17: 17-23. PMID 24581688 DOI: 10.1016/j.mib.2013.10.007  0.64
2014 Rothchild AC, Jayaraman P, Nunes-Alves C, Behar SM. iNKT cell production of GM-CSF controls Mycobacterium tuberculosis. Plos Pathogens. 10: e1003805. PMID 24391492 DOI: 10.1371/journal.ppat.1003805  0.6
2013 Zhang YJ, Reddy MC, Ioerger TR, Rothchild AC, Dartois V, Schuster BM, Trauner A, Wallis D, Galaviz S, Huttenhower C, Sacchettini JC, Behar SM, Rubin EJ. Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing. Cell. 155: 1296-308. PMID 24315099 DOI: 10.1016/j.cell.2013.10.045  0.64
2013 Nunes-Alves C, Nobrega C, Behar SM, Correia-Neves M. Tolerance has its limits: how the thymus copes with infection. Trends in Immunology. 34: 502-10. PMID 23871487 DOI: 10.1016/j.it.2013.06.004  0.6
2013 Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson AC, Kuchroo VK, Remold HG, Behar SM. IL-1β promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation. Journal of Immunology (Baltimore, Md. : 1950). 190: 4196-204. PMID 23487424 DOI: 10.4049/jimmunol.1202688  0.64
2013 Behar SM. Antigen-specific CD8(+) T cells and protective immunity to tuberculosis. Advances in Experimental Medicine and Biology. 783: 141-63. PMID 23468108 DOI: 10.1007/978-1-4614-6111-1_8  0.64
2013 Divangahi M, Behar SM, Remold H. Dying to live: how the death modality of the infected macrophage affects immunity to tuberculosis. Advances in Experimental Medicine and Biology. 783: 103-20. PMID 23468106 DOI: 10.1007/978-1-4614-6111-1_6  0.64
2013 Nobrega C, Nunes-Alves C, Cerqueira-Rodrigues B, Roque S, Barreira-Silva P, Behar SM, Correia-Neves M. T cells home to the thymus and control infection. Journal of Immunology (Baltimore, Md. : 1950). 190: 1646-58. PMID 23315077 DOI: 10.4049/jimmunol.1202412  0.6
2013 Tatituri RV, Watts GF, Bhowruth V, Barton N, Rothchild A, Hsu FF, Almeida CF, Cox LR, Eggeling L, Cardell S, Rossjohn J, Godfrey DI, Behar SM, Besra GS, Brenner MB, et al. Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs. Proceedings of the National Academy of Sciences of the United States of America. 110: 1827-32. PMID 23307809 DOI: 10.1073/pnas.1220601110  0.64
2012 Sada-Ovalle I, Chávez-Galán L, Torre-Bouscoulet L, Nava-Gamiño L, Barrera L, Jayaraman P, Torres-Rojas M, Salazar-Lezama MA, Behar SM. The Tim3-galectin 9 pathway induces antibacterial activity in human macrophages infected with Mycobacterium tuberculosis. Journal of Immunology (Baltimore, Md. : 1950). 189: 5896-902. PMID 23180819 DOI: 10.4049/jimmunol.1200990  0.56
2012 Martin CJ, Booty MG, Rosebrock TR, Nunes-Alves C, Desjardins DM, Keren I, Fortune SM, Remold HG, Behar SM. Efferocytosis is an innate antibacterial mechanism. Cell Host & Microbe. 12: 289-300. PMID 22980326 DOI: 10.1016/j.chom.2012.06.010  0.64
2011 Layre E, Sweet L, Hong S, Madigan CA, Desjardins D, Young DC, Cheng TY, Annand JW, Kim K, Shamputa IC, McConnell MJ, Debono CA, Behar SM, Minnaard AJ, Murray M, et al. A comparative lipidomics platform for chemotaxonomic analysis of Mycobacterium tuberculosis. Chemistry & Biology. 18: 1537-49. PMID 22195556 DOI: 10.1016/j.chembiol.2011.10.013  0.64
2011 Nandi B, Behar SM. Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection. The Journal of Experimental Medicine. 208: 2251-62. PMID 21967766 DOI: 10.1084/jem.20110919  0.64
2011 Sakuishi K, Jayaraman P, Behar SM, Anderson AC, Kuchroo VK. Emerging Tim-3 functions in antimicrobial and tumor immunity. Trends in Immunology. 32: 345-9. PMID 21697013 DOI: 10.1016/j.it.2011.05.003  0.56
2011 Sillé FC, Martin C, Jayaraman P, Rothchild A, Fortune S, Besra GS, Behar SM, Boes M. Requirement for invariant chain in macrophages for Mycobacterium tuberculosis replication and CD1d antigen presentation. Infection and Immunity. 79: 3053-63. PMID 21576321 DOI: 10.1128/IAI.01108-10  0.56
2011 Sillé FC, Martin C, Jayaraman P, Rothchild A, Besra GS, Behar SM, Boes M. Critical role for invariant chain in CD1d-mediated selection and maturation of Vα14-invariant NKT cells. Immunology Letters. 139: 33-41. PMID 21565221 DOI: 10.1016/j.imlet.2011.04.012  0.56
2011 Behar SM, Martin CJ, Nunes-Alves C, Divangahi M, Remold HG. Lipids, apoptosis, and cross-presentation: links in the chain of host defense against Mycobacterium tuberculosis. Microbes and Infection / Institut Pasteur. 13: 749-56. PMID 21458584 DOI: 10.1016/j.micinf.2011.03.002  0.64
2011 Behar SM, Martin CJ, Booty MG, Nishimura T, Zhao X, Gan HX, Divangahi M, Remold HG. Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis. Mucosal Immunology. 4: 279-87. PMID 21307848 DOI: 10.1038/mi.2011.3  0.64
2011 Woodworth JS, Shin D, Volman M, Nunes-Alves C, Fortune SM, Behar SM. Mycobacterium tuberculosis directs immunofocusing of CD8+ T cell responses despite vaccination. Journal of Immunology (Baltimore, Md. : 1950). 186: 1627-37. PMID 21178003 DOI: 10.4049/jimmunol.1002911  0.64
2010 Jayaraman P, Sada-Ovalle I, Beladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar SM. Tim3 binding to galectin-9 stimulates antimicrobial immunity. The Journal of Experimental Medicine. 207: 2343-54. PMID 20937702 DOI: 10.1084/jem.20100687  0.64
2010 Behar SM, Divangahi M, Remold HG. Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy? Nature Reviews. Microbiology. 8: 668-74. PMID 20676146 DOI: 10.1038/nrmicro2387  0.64
2010 Divangahi M, Desjardins D, Nunes-Alves C, Remold HG, Behar SM. Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis. Nature Immunology. 11: 751-8. PMID 20622882 DOI: 10.1038/ni.1904  0.6
2010 Zeissig S, Dougan SK, Barral DC, Junker Y, Chen Z, Kaser A, Ho M, Mandel H, McIntyre A, Kennedy SM, Painter GF, Veerapen N, Besra GS, Cerundolo V, Yue S, ... ... Behar SM, et al. Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function. The Journal of Clinical Investigation. 120: 2889-99. PMID 20592474 DOI: 10.1172/JCI42703  0.64
2010 Garces A, Atmakuri K, Chase MR, Woodworth JS, Krastins B, Rothchild AC, Ramsdell TL, Lopez MF, Behar SM, Sarracino DA, Fortune SM. EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity. Plos Pathogens. 6: e1000957. PMID 20585630 DOI: 10.1371/journal.ppat.1000957  0.64
2010 Sada-Ovalle I, Sköld M, Tian T, Besra GS, Behar SM. Alpha-galactosylceramide as a therapeutic agent for pulmonary Mycobacterium tuberculosis infection. American Journal of Respiratory and Critical Care Medicine. 182: 841-7. PMID 20508216 DOI: 10.1164/rccm.200912-1921OC  0.4
2010 Kiener HP, Watts GF, Cui Y, Wright J, Thornhill TS, Sköld M, Behar SM, Niederreiter B, Lu J, Cernadas M, Coyle AJ, Sims GP, Smolen J, Warman ML, Brenner MB, et al. Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture. Arthritis and Rheumatism. 62: 742-52. PMID 20131230 DOI: 10.1002/art.27285  0.64
2009 Divangahi M, Chen M, Gan H, Desjardins D, Hickman TT, Lee DM, Fortune S, Behar SM, Remold HG. Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair. Nature Immunology. 10: 899-906. PMID 19561612 DOI: 10.1038/ni.1758  0.64
2008 Sada-Ovalle I, Chiba A, Gonzales A, Brenner MB, Behar SM. Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria. Plos Pathogens. 4: e1000239. PMID 19079582 DOI: 10.1371/journal.ppat.1000239  0.64
2008 Woodworth JS, Wu Y, Behar SM. Mycobacterium tuberculosis-specific CD8+ T cells require perforin to kill target cells and provide protection in vivo. Journal of Immunology (Baltimore, Md. : 1950). 181: 8595-603. PMID 19050279  0.64
2008 Chen M, Divangahi M, Gan H, Shin DS, Hong S, Lee DM, Serhan CN, Behar SM, Remold HG. Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death. The Journal of Experimental Medicine. 205: 2791-801. PMID 18955568 DOI: 10.1084/jem.20080767  0.48
2008 Sköld M, Behar SM. Tuberculosis triggers a tissue-dependent program of differentiation and acquisition of effector functions by circulating monocytes. Journal of Immunology (Baltimore, Md. : 1950). 181: 6349-60. PMID 18941226  0.64
2008 Pollock NR, Campos-Neto A, Kashino S, Napolitano D, Behar SM, Shin D, Sloutsky A, Joshi S, Guillet J, Wong M, Nardell E. Discordant QuantiFERON-TB Gold test results among US healthcare workers with increased risk of latent tuberculosis infection: a problem or solution? Infection Control and Hospital Epidemiology. 29: 878-86. PMID 18713053 DOI: 10.1086/590262  0.6
2008 Matsunaga I, Naka T, Talekar RS, McConnell MJ, Katoh K, Nakao H, Otsuka A, Behar SM, Yano I, Moody DB, Sugita M. Mycolyltransferase-mediated glycolipid exchange in Mycobacteria. The Journal of Biological Chemistry. 283: 28835-41. PMID 18703502 DOI: 10.1074/jbc.M805776200  0.64
2008 Woodworth JS, Fortune SM, Behar SM. Bacterial protein secretion is required for priming of CD8+ T cells specific for the Mycobacterium tuberculosis antigen CFP10. Infection and Immunity. 76: 4199-205. PMID 18591224 DOI: 10.1128/IAI.00307-08  0.64
2008 Wu Y, Woodworth JS, Shin DS, Morris S, Behar SM. Vaccine-elicited 10-kilodalton culture filtrate protein-specific CD8+ T cells are sufficient to mediate protection against Mycobacterium tuberculosis infection. Infection and Immunity. 76: 2249-55. PMID 18332205 DOI: 10.1128/IAI.00024-08  0.64
2007 Behar SM, Woodworth JS, Wu Y. Next generation: tuberculosis vaccines that elicit protective CD8+ T cells. Expert Review of Vaccines. 6: 441-56. PMID 17542758 DOI: 10.1586/14760584.6.3.441  0.64
2006 Woodworth JS, Behar SM. Mycobacterium tuberculosis-specific CD8+ T cells and their role in immunity. Critical Reviews in Immunology. 26: 317-52. PMID 17073557  0.64
2006 Kamath A, Woodworth JS, Behar SM. Antigen-specific CD8+ T cells and the development of central memory during Mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 177: 6361-9. PMID 17056567  0.64
2006 Kinjo Y, Tupin E, Wu D, Fujio M, Garcia-Navarro R, Benhnia MR, Zajonc DM, Ben-Menachem G, Ainge GD, Painter GF, Khurana A, Hoebe K, Behar SM, Beutler B, Wilson IA, et al. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nature Immunology. 7: 978-86. PMID 16921381 DOI: 10.1038/ni1380  0.64
2006 Ghosh S, Chackerian AA, Parker CM, Ballantyne CM, Behar SM. The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 176: 4914-22. PMID 16585587  0.64
2005 Sköld M, Xiong X, Illarionov PA, Besra GS, Behar SM. Interplay of cytokines and microbial signals in regulation of CD1d expression and NKT cell activation. Journal of Immunology (Baltimore, Md. : 1950). 175: 3584-93. PMID 16148102  0.4
2005 Tian T, Woodworth J, Sköld M, Behar SM. In vivo depletion of CD11c+ cells delays the CD4+ T cell response to Mycobacterium tuberculosis and exacerbates the outcome of infection. Journal of Immunology (Baltimore, Md. : 1950). 175: 3268-72. PMID 16116218  0.64
2005 Kamath AB, Behar SM. Anamnestic responses of mice following Mycobacterium tuberculosis infection. Infection and Immunity. 73: 6110-8. PMID 16113332 DOI: 10.1128/IAI.73.9.6110-6118.2005  0.64
2005 Sköld M, Behar SM. The role of group 1 and group 2 CD1-restricted T cells in microbial immunity. Microbes and Infection / Institut Pasteur. 7: 544-51. PMID 15777730 DOI: 10.1016/j.micinf.2004.12.012  0.64
2004 Kamath AB, Woodworth J, Xiong X, Taylor C, Weng Y, Behar SM. Cytolytic CD8+ T cells recognizing CFP10 are recruited to the lung after Mycobacterium tuberculosis infection. The Journal of Experimental Medicine. 200: 1479-89. PMID 15557351 DOI: 10.1084/jem.20041690  0.64
2003 Cernadas M, Sugita M, van der Wel N, Cao X, Gumperz JE, Maltsev S, Besra GS, Behar SM, Peters PJ, Brenner MB. Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development. Journal of Immunology (Baltimore, Md. : 1950). 171: 4149-55. PMID 14530337  0.64
2003 Sköld M, Behar SM. Role of CD1d-restricted NKT cells in microbial immunity. Infection and Immunity. 71: 5447-55. PMID 14500461 DOI: 10.1128/IAI.71.10.5447-5455.2003  0.64
2003 Chackerian AA, Behar SM. Susceptibility to Mycobacterium tuberculosis: lessons from inbred strains of mice. Tuberculosis (Edinburgh, Scotland). 83: 279-85. PMID 12972341 DOI: 10.1016/S1472-9792(03)00017-9  0.64
2003 Rauch J, Gumperz J, Robinson C, Sköld M, Roy C, Young DC, Lafleur M, Moody DB, Brenner MB, Costello CE, Behar SM. Structural features of the acyl chain determine self-phospholipid antigen recognition by a CD1d-restricted invariant NKT (iNKT) cell. The Journal of Biological Chemistry. 278: 47508-15. PMID 12963715 DOI: 10.1074/jbc.M308089200  0.64
2002 Dascher CC, Hiromatsu K, Xiong X, Sugita M, Buhlmann JE, Dodge IL, Lee SY, Roura-Mir C, Watts GF, Roy CJ, Behar SM, Clemens DL, Porcelli SA, Brenner MB. Conservation of CD1 intracellular trafficking patterns between mammalian species. Journal of Immunology (Baltimore, Md. : 1950). 169: 6951-8. PMID 12471129  0.64
2002 Chackerian A, Alt J, Perera V, Behar SM. Activation of NKT cells protects mice from tuberculosis. Infection and Immunity. 70: 6302-9. PMID 12379709 DOI: 10.1128/IAI.70.11.6302-6309.2002  0.64
2002 Chackerian AA, Alt JM, Perera TV, Dascher CC, Behar SM. Dissemination of Mycobacterium tuberculosis is influenced by host factors and precedes the initiation of T-cell immunity. Infection and Immunity. 70: 4501-9. PMID 12117962 DOI: 10.1128/IAI.70.8.4501-4509.2002  0.64
2002 Hiromatsu K, Dascher CC, Sugita M, Gingrich-Baker C, Behar SM, LeClair KP, Brenner MB, Porcelli SA. Characterization of guinea-pig group 1 CD1 proteins. Immunology. 106: 159-72. PMID 12047745  0.6
2002 Grant EP, Beckman EM, Behar SM, Degano M, Frederique D, Besra GS, Wilson IA, Porcelli SA, Furlong ST, Brenner MB. Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex. Journal of Immunology (Baltimore, Md. : 1950). 168: 3933-40. PMID 11937549  0.4
2001 Chackerian AA, Perera TV, Behar SM. Gamma interferon-producing CD4+ T lymphocytes in the lung correlate with resistance to infection with Mycobacterium tuberculosis. Infection and Immunity. 69: 2666-74. PMID 11254633 DOI: 10.1128/IAI.69.4.2666-2674.2001  0.64
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