R Scott McIvor - Publications

Affiliations: 
Microbiology, Immunology and Cancer Biology University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Molecular Biology, Virology Biology, Microbiology Biology

153 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Webber BR, Johnson MJ, Skeate JG, Slipek NJ, Lahr WS, DeFeo AP, Mills LJ, Qiu X, Rathmann B, Diers MD, Wick B, Henley T, Choudhry M, Starr TK, McIvor RS, et al. Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair. Nature Biomedical Engineering. PMID 38092857 DOI: 10.1038/s41551-023-01157-4  0.306
2022 Cowan MJ, Yu J, Facchino J, Fraser-Browne C, Sanford U, Kawahara M, Dara J, Long-Boyle J, Oh J, Chan W, Chag S, Broderick L, Chellapandian D, Decaluwe H, Golski C, ... ... McIvor RS, et al. Lentiviral Gene Therapy for Artemis-Deficient SCID. The New England Journal of Medicine. 387: 2344-2355. PMID 36546626 DOI: 10.1056/NEJMoa2206575  0.3
2022 Sipe CJ, Kluesner MG, Bingea SP, Lahr WS, Andrew AA, Wang M, DeFeo AP, Hinkel TL, Laoharawee K, Wagner JE, MacMillan ML, Vercellotti GM, Tolar J, Osborn MJ, McIvor RS, et al. Correction of Fanconi Anemia Mutations Using Digital Genome Engineering. International Journal of Molecular Sciences. 23. PMID 35955545 DOI: 10.3390/ijms23158416  0.327
2020 Belur LR, Podetz-Pedersen KM, Tran TA, Mesick JA, Singh NM, Riedl M, Vulchanova L, Kozarsky KF, McIvor RS. Intravenous delivery for treatment of mucopolysaccharidosis type I: A comparison of AAV serotypes 9 and rh10. Molecular Genetics and Metabolism Reports. 24: 100604. PMID 32461912 DOI: 10.1016/J.Ymgmr.2020.100604  0.455
2020 McIvor RS, de Laat R, Mei X, Meeker KD, Swietlicka M, Scholz M, Olson ER. Iduronidase-transposed human B lymphocytes correct enzyme deficiency and glycosaminoglycan storage disease in immunodeficient mucopolysaccharidosis type I mice Molecular Genetics and Metabolism. 129: S108. DOI: 10.1016/J.Ymgme.2019.11.276  0.33
2020 Belur L, McKenzie J, Podetz-Pedersen K, Karlen A, de Souza PC, LaBarre S, Smith M, Huber A, Detellis J, Gagnidze K, Parsons G, Tsai H, McIvor RS, Bonner M. Systemic high-level IDUA enzyme activity with correction of neurologic deficit in mucopolysaccharidosis type I mice by lentiviral transduction of hematopoietic stem cells Molecular Genetics and Metabolism. 129: S30-S31. DOI: 10.1016/J.Ymgme.2019.11.052  0.347
2020 Cowan MJ, Yu J, Facchino J, Chag S, Fraser-Browne C, Long-Boyle J, Kawahara M, Sanford U, Oh J, Teoh S, Punwani D, Dara J, Dvorak CC, Broderick L, Hu D, ... ... McIvor RS, et al. Early Outcome of a Phase I/II Clinical Trial (NCT03538899) of Gene-Corrected Autologous CD34+ Hematopoietic Cells and Low-Exposure Busulfan in Newly Diagnosed Patients with Artemis-Deficient Severe Combined Immunodeficiency (ART-SCID) Biology of Blood and Marrow Transplantation. 26: S88-S89. DOI: 10.1016/J.Bbmt.2019.12.589  0.382
2018 Ou L, DeKelver RC, Rohde M, Tom S, Radeke R, St Martin SJ, Santiago Y, Sproul S, Przybilla MJ, Koniar BL, Podetz-Pedersen KM, Laoharawee K, Cooksley RD, Meyer KE, Holmes MC, ... McIvor RS, et al. ZFN-Mediated In Vivo Genome Editing Corrects Murine Hurler Syndrome. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 30528089 DOI: 10.1016/J.Ymthe.2018.10.018  0.4
2018 Laoharawee K, DeKelver RC, Podetz-Pedersen KM, Rohde M, Sproul S, Nguyen HO, Nguyen T, St Martin SJ, Ou L, Tom S, Radeke R, Meyer KE, Holmes MC, Whitley CB, Wechsler T, ... McIvor RS, et al. Dose-Dependent Prevention of Metabolic and Neurologic Disease in Murine MPS II by ZFN-Mediated In Vivo Genome Editing. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29580682 DOI: 10.1016/J.Ymthe.2018.03.002  0.392
2017 Aronovich EL, Hyland KA, Hall BC, Bell JB, Olson ER, Rusten MU, Hunter DW, Ellinwood NM, McIvor RS, Hackett PB. Prolonged expression of secreted enzymes in dogs after liver-directed delivery of Sleeping Beauty transposons: implications for non-viral gene therapy of systemic disease. Human Gene Therapy. PMID 28530135 DOI: 10.1089/Hum.2017.004  0.509
2017 Laoharawee K, Podetz-Pedersen KM, Nguyen TT, Evenstar LB, Kitto KF, Nan Z, Fairbanks CA, Low WC, Kozarsky KF, McIvor RS. Prevention of Neurocognitive Deficiency in Mucopolysaccharidosis Type II Mice By CNS-Directed, AAV9-Mediated Iduronate Sulfatase Gene Transfer. Human Gene Therapy. PMID 28478695 DOI: 10.1089/Hum.2016.184  0.401
2017 Belur LR, Temme A, Podetz-Pedersen KM, Riedl M, Vulchanova L, Robinson N, Hanson LR, Kozarsky KF, Orchard PJ, Frey Ii WH, Low WC, McIvor RS. Intranasal AAV Mediated Gene Delivery and Expression of Human Iduronidase in the CNS: A Non-invasive and Effective Approach for Prevention of Neurologic Disease in Mucopolysaccharidosis Type I. Human Gene Therapy. PMID 28462595 DOI: 10.1089/Hum.2017.187  0.384
2017 Hyland KA, Aronovich EL, Olson ER, Bell JB, Rusten MU, Gunther R, Hunter DW, Hackett PB, McIvor RS. Transgene Expression in Dogs after Liver-Directed Hydrodynamic Delivery of Sleeping Beauty Transposons Using Balloon Catheters. Human Gene Therapy. PMID 28447859 DOI: 10.1089/Hum.2017.003  0.486
2017 Belur L, Podetz-Pedersen KM, Low WC, McIvor RS. Recovery of neurologic function in mucopolysaccharidosis type I mice with existing neurocognitive dysfunction by treatment with AAV9-IDUA vector Molecular Genetics and Metabolism. 120: S26. DOI: 10.1016/J.Ymgme.2016.11.038  0.327
2016 Punwani D, Kawahara M, Yu J, Sanford U, Roy S, Patel K, Carbonaro DA, Karlen AD, Khan S, Cornetta KG, Rothe M, Schambach A, Kohn DB, Malech HL, McIvor RS, et al. Lentivirus Mediated Correction of Artemis-deficient Severe Combined Immunodeficiency. Human Gene Therapy. PMID 27611239 DOI: 10.1089/Hum.2016.064  0.47
2016 Podetz-Pedersen KM, Olson ER, Somia NV, Russell SJ, McIvor RS. A Broad Range of Dose Optima Achieve High-level, Long-term Gene Expression After Hydrodynamic Delivery of Sleeping Beauty Transposons Using Hyperactive SB100x Transposase. Molecular Therapy. Nucleic Acids. 5: e279. PMID 26784638 DOI: 10.1038/Mtna.2015.54  0.454
2016 Ou L, DeKelver R, Tom S, Radeke R, Rohde M, Manning-Bog A, Sproul S, Przybilla MJ, Komar BL, Podetz-Pedersen K, Laoharawee K, Cooksley RD, Holmes MC, Wechsler T, McIvor RS, et al. 485. ZFN-Mediated Liver-Targeting Gene Therapy Corrects Systemic and Neurological Disease of Mucopolysaccharidosis Type I Molecular Therapy. 24: S192-S193. DOI: 10.1016/S1525-0016(16)33294-4  0.464
2016 Laoharawee K, DeKelver R, Podetz-Petersen KM, Tom S, Radeke R, Rohde M, Manning-Bog A, Sproul S, Ou L, Meyer K, Holmes MC, Whitley CB, Wechsler T, McIvor RS. 484. In Vivo Zinc-Finger Nuclease Mediated Iduronate-2-Sulfatase (IDS) Target Gene Insertion and Correction of Metabolic Disease in a Mouse Model of Mucopolysaccharidosis Type II (MPS II) Molecular Therapy. 24: S192. DOI: 10.1016/S1525-0016(16)33293-2  0.442
2016 Aronovich EL, Hyland KA, Hall BC, Bell JB, Olson ER, Rusten M, Hunter DW, Whitley CB, Ellinwood NM, McIvor RS, Hackett PB. 439. Prolonged Expression of Secreted Enzymes in Dogs After Liver Delivery of Sleeping Beauty Transposons: Implications for Non-Viral Gene Therapy of Mucopolysaccharidoses Types I and VII Molecular Therapy. 24: S174. DOI: 10.1016/S1525-0016(16)33248-8  0.47
2016 Belur L, Tran TA, Pedersen KM, Riedl M, Vulchanova L, Kozarsky K, Low WC, McIvor RS. 369. Therapeutic Effectiveness of AAV-Mediated Iduronidase Delivery to the CNS Following Intravenous Administration in a Murine Model of Mucopolysaccharidosis Type I Molecular Therapy. 24: S148. DOI: 10.1016/S1525-0016(16)33178-1  0.425
2016 Laoharawee K, Podetz-Petersen KM, Kitto K, Vulchanova L, Fairbanks C, Kozarsky K, Low WC, McIvor RS. 86. AAV9 Mediated Correction of Iduronate-2-Sulfatase Deficiency in the Central Nervous System to Prevent the Onset of Neurologic Deficits in a Murine Model of Mucopolysaccharidosis Type II Molecular Therapy. 24: S38. DOI: 10.1016/S1525-0016(16)32895-7  0.398
2015 Filareto A, Rinaldi F, Arpke RW, Darabi R, Belanto JJ, Toso EA, Miller AZ, Ervasti JM, McIvor RS, Kyba M, Perlingeiro RC. Pax3-induced expansion enables the genetic correction of dystrophic satellite cells. Skeletal Muscle. 5: 36. PMID 26504514 DOI: 10.1186/S13395-015-0061-7  0.444
2015 Hyland KA, Olson ER, McIvor RS. Sleeping Beauty-Mediated Drug Resistance Gene Transfer in Human Hematopoietic Progenitor Cells. Human Gene Therapy. 26: 657-63. PMID 26176276 DOI: 10.1089/Hum.2015.058  0.522
2015 Multhaup MM, Podetz-Pedersen KM, Karlen AD, Olson ER, Gunther R, Somia NV, Blazar BR, Cowan MJ, McIvor RS. Role of transgene regulation in ex vivo lentiviral correction of artemis deficiency. Human Gene Therapy. 26: 232-43. PMID 25738323 DOI: 10.1089/Hum.2014.062  0.789
2015 Wolf DA, Banerjee S, Hackett PB, Whitley CB, McIvor RS, Low WC. Gene therapy for neurologic manifestations of mucopolysaccharidoses. Expert Opinion On Drug Delivery. 12: 283-96. PMID 25510418 DOI: 10.1517/17425247.2015.966682  0.34
2015 Herbig EJ, Xu M, Hyland KA, Olson E, Aronovich E, Scholz M, Hackett PB, McIvor RS. Sleeping Beauty engineered human B lymphocytes express therapeutic levels of human iduronidase: A new approach for mucopolysaccharidosis type I Molecular Genetics and Metabolism. 114: S53-S54. DOI: 10.1016/J.Ymgme.2014.12.110  0.384
2014 Schuster DJ, Belur LR, Riedl MS, Schnell SA, Podetz-Pedersen KM, Kitto KF, McIvor RS, Vulchanova L, Fairbanks CA. Supraspinal gene transfer by intrathecal adeno-associated virus serotype 5. Frontiers in Neuroanatomy. 8: 66. PMID 25147505 DOI: 10.3389/Fnana.2014.00066  0.33
2014 Podetz-Pedersen KM, Vezys V, Somia NV, Russell SJ, McIvor RS. Cellular immune response against firefly luciferase after sleeping beauty-mediated gene transfer in vivo. Human Gene Therapy. 25: 955-65. PMID 25093708 DOI: 10.1089/Hum.2014.048  0.493
2014 Schuster DJ, Dykstra JA, Riedl MS, Kitto KF, Belur LR, McIvor RS, Elde RP, Fairbanks CA, Vulchanova L. Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse. Frontiers in Neuroanatomy. 8: 42. PMID 24959122 DOI: 10.3389/Fnana.2014.00042  0.354
2014 Moriarity BS, Rahrmann EP, Beckmann DA, Conboy CB, Watson AL, Carlson DF, Olson ER, Hyland KA, Fahrenkrug SC, McIvor RS, Largaespada DA. Simple and efficient methods for enrichment and isolation of endonuclease modified cells. Plos One. 9: e96114. PMID 24798371 DOI: 10.1371/Journal.Pone.0096114  0.467
2014 McIvor RS, Nan Z, Podetz-Pedersen KM, Kitto K, Hanson LR, Wolf DA, Kozarsky K, Fairbanks CA, Frey WH, Low WC, Belur LR. Intrathecal and intranasal infusion of adeno-associated virus vector: non-invasive routes of administration achieving corrective levels of iduronidase expression throughout the brain for gene therapy of mucopolysaccharidosis type I Molecular Genetics and Metabolism. 111: S75-S76. DOI: 10.1016/J.Ymgme.2013.12.174  0.429
2013 Adil M, Belur L, Pearce TR, Levine RM, Tisdale AW, Sorenson BS, McIvor RS, Kokkoli E. PR_b functionalized stealth liposomes for targeted delivery to metastatic colon cancer. Biomaterials Science. 1: 393-401. PMID 32481904 DOI: 10.1039/C2Bm00128D  0.376
2013 Aronovich EL, Hall BC, Bell JB, McIvor RS, Hackett PB. Quantitative analysis of α-L-iduronidase expression in immunocompetent mice treated with the Sleeping Beauty transposon system. Plos One. 8: e78161. PMID 24205141 DOI: 10.1371/Journal.Pone.0078161  0.474
2013 Filareto A, Parker S, Darabi R, Borges L, Iacovino M, Schaaf T, Mayerhofer T, Chamberlain JS, Ervasti JM, McIvor RS, Kyba M, Perlingeiro RC. An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells. Nature Communications. 4: 1549. PMID 23462992 DOI: 10.1038/Ncomms2550  0.396
2013 McIvor RS, Podetz-Pedersen K, Nan Z, Karlen A, Slepushkin V, Roy A, Yakovlev G, Gong Z, Muenzer J, Dropulic B. Gene therapy for Hunter syndrome: Prevention of neurocognitive deficit in MPS II mice by engraftment with lentiviral vector-transduced hematopoietic stem cells (HSC) but not with wild type HSC Molecular Genetics and Metabolism. 108: S64. DOI: 10.1016/J.Ymgme.2012.11.163  0.414
2012 Wolf DA, Hanson LR, Aronovich EL, Nan Z, Low WC, Frey WH, McIvor RS. Lysosomal enzyme can bypass the blood-brain barrier and reach the CNS following intranasal administration. Molecular Genetics and Metabolism. 106: 131-4. PMID 22420937 DOI: 10.1016/J.Ymgme.2012.02.006  0.334
2012 Aronovich E, Bell J, Podetz-Petersen K, Koniar B, McIvor RS, Hackett P. Prolonged High-Level Expression of IDUA from Sleeping Beauty Transposons in Immunocompetent Mice Molecular Genetics and Metabolism. 105: S18. DOI: 10.1016/J.Ymgme.2011.11.020  0.391
2011 Wilber A, Ulloa Montoya F, Hammer L, Moriarity BS, Geurts AM, Largaespada DA, Verfaillie CM, McIvor RS, Lakshmipathy U. Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells. Stem Cells International. 2011: 717069. PMID 21977042 DOI: 10.4061/2011/717069  0.708
2011 Multhaup MM, Gurram S, Podetz-Pedersen KM, Karlen AD, Swanson DL, Somia NV, Hackett PB, Cowan MJ, McIvor RS. Characterization of the human artemis promoter by heterologous gene expression in vitro and in vivo. Dna and Cell Biology. 30: 751-61. PMID 21663454 DOI: 10.1089/Dna.2011.1244  0.817
2011 Aronovich EL, McIvor RS, Hackett PB. The Sleeping Beauty transposon system: a non-viral vector for gene therapy. Human Molecular Genetics. 20: R14-20. PMID 21459777 DOI: 10.1093/Hmg/Ddr140  0.493
2011 Wolf DA, Lenander AW, Nan Z, Belur LR, Whitley CB, Gupta P, Low WC, McIvor RS. Direct gene transfer to the CNS prevents emergence of neurologic disease in a murine model of mucopolysaccharidosis type I. Neurobiology of Disease. 43: 123-33. PMID 21397026 DOI: 10.1016/J.Nbd.2011.02.015  0.461
2011 Belur LR, Podetz-Pedersen KM, Sorenson BS, Hsu AH, Parker JB, Carlson CS, Saltzman DA, Ramakrishnan S, McIvor RS. Inhibition of angiogenesis and suppression of colorectal cancer metastatic to the liver using the Sleeping Beauty Transposon System. Molecular Cancer. 10: 14. PMID 21310067 DOI: 10.1186/1476-4598-10-14  0.371
2010 Gori JL, McIvor RS, Kaufman DS. Methotrexate supports in vivo selection of human embryonic stem cell derived-hematopoietic cells expressing dihydrofolate reductase. Bioengineered Bugs. 1: 434-6. PMID 21468213 DOI: 10.4161/Bbug.1.6.12390  0.494
2010 Vulchanova L, Schuster DJ, Belur LR, Riedl MS, Podetz-Pedersen KM, Kitto KF, Wilcox GL, McIvor RS, Fairbanks CA. Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture. Molecular Pain. 6: 31. PMID 20509925 DOI: 10.1186/1744-8069-6-31  0.335
2010 Multhaup M, Karlen AD, Swanson DL, Wilber A, Somia NV, Cowan MJ, McIvor RS. Cytotoxicity associated with artemis overexpression after lentiviral vector-mediated gene transfer. Human Gene Therapy. 21: 865-75. PMID 20163250 DOI: 10.1089/Hum.2009.162  0.802
2010 Gori JL, Tian X, Swanson D, Gunther R, Shultz LD, McIvor RS, Kaufman DS. In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase. Gene Therapy. 17: 238-49. PMID 19829316 DOI: 10.1038/Gt.2009.131  0.399
2010 Podetz-Pedersen KM, Bell JB, Steele TW, Wilber A, Shier WT, Belur LR, McIvor RS, Hackett PB. Gene expression in lung and liver after intravenous infusion of polyethylenimine complexes of Sleeping Beauty transposons. Human Gene Therapy. 21: 210-20. PMID 19761403 DOI: 10.1089/Hum.2009.128  0.73
2010 Wolf D, Nan Z, Belur L, Swanson D, Lenander A, Whitley C, Gupta P, Low W, McIvor RS. 152. Long-term biochemical and neurobehavioral correction in a murine model of mucopolysaccharidosis type I following neonatal intracerebroventricular administration of a therapeutic adeno-associated virus vector Molecular Genetics and Metabolism. 99: S40. DOI: 10.1016/J.Ymgme.2009.10.169  0.332
2009 Vink CA, Gaspar HB, Gabriel R, Schmidt M, McIvor RS, Thrasher AJ, Qasim W. Sleeping beauty transposition from nonintegrating lentivirus. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1197-204. PMID 19417741 DOI: 10.1038/Mt.2009.94  0.494
2009 Xue X, Huang X, Nodland SE, Mátés L, Ma L, Izsvák Z, Ivics Z, LeBien TW, McIvor RS, Wagner JE, Zhou X. Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system. Blood. 114: 1319-30. PMID 19414858 DOI: 10.1182/Blood-2009-03-210005  0.375
2009 Aronovich EL, Bell JB, Khan SA, Belur LR, Gunther R, Koniar B, Schachern PA, Parker JB, Carlson CS, Whitley CB, McIvor RS, Gupta P, Hackett PB. Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1136-44. PMID 19384290 DOI: 10.1038/Mt.2009.87  0.474
2009 Huang X, Wilber A, McIvor RS, Zhou X. DNA transposons for modification of human primary T lymphocytes. Methods in Molecular Biology (Clifton, N.J.). 506: 115-26. PMID 19110623 DOI: 10.1007/978-1-59745-409-4_9  0.727
2009 McIvor RS, Wolf DA, Podetz-Petersen K, Nan Z, Whitley CB, Muenzer J, Orchard PJ, Low WC. 86. Ex vivo lentiviral gene transfer targeting hematopoietic stem cells for therapy of mucopolysaccharidosis type II, Hunter syndrome Molecular Genetics and Metabolism. 96: S30-S31. DOI: 10.1016/J.Ymgme.2008.11.087  0.381
2009 Wilber A, Tolar J, Blazar BR, Verfaillie CM, Lakshmipathy U, Kaufman DS, McIvor RS. Sleeping Beauty-Mediated Transposition in Stem Cells Emerging Technology Platforms For Stem Cells. 341-362. DOI: 10.1002/9780470454923.ch19  0.592
2008 Gao Y, Zu T, Low WC, Orr HT, McIvor RS. Antisense RNA sequences modulating the ataxin-1 message: molecular model of gene therapy for spinocerebellar ataxia type 1, a dominant-acting unstable trinucleotide repeat disease. Cell Transplantation. 17: 723-34. PMID 19044200 DOI: 10.3727/096368908786516729  0.398
2008 Belur LR, Kaemmerer WF, McIvor RS, Low WC. Adeno-associated virus type 2 vectors: transduction and long-term expression in cerebellar Purkinje cells in vivo is mediated by the fibroblast growth factor receptor 1 : bFGFR-1 mediates AAV2 transduction of Purkinje cells. Archives of Virology. 153: 2107-10. PMID 18937030 DOI: 10.1007/S00705-008-0222-7  0.388
2008 Belur LR, McIvor RS, Wilber A. Liver-directed gene therapy using the sleeping beauty transposon system. Methods in Molecular Biology (Clifton, N.J.). 434: 267-76. PMID 18470650 DOI: 10.1007/978-1-60327-248-3_16  0.728
2008 Wangensteen KJ, Wilber A, Keng VW, He Z, Matise I, Wangensteen L, Carson CM, Chen Y, Steer CJ, McIvor RS, Largaespada DA, Wang X, Ekker SC. A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver. Hepatology (Baltimore, Md.). 47: 1714-24. PMID 18435462 DOI: 10.1002/Hep.22195  0.707
2008 Huang X, Guo H, Kang J, Choi S, Zhou TC, Tammana S, Lees CJ, Li ZZ, Milone M, Levine BL, Tolar J, June CH, McIvor RS, Wagner JE, Blazar BR, et al. Sleeping beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies Molecular Therapy. 16: 580-589. PMID 18227839 DOI: 10.1038/Sj.Mt.6300404  0.395
2008 Wangensteen KJ, Wilber A, Keng VW, Chen Y, Matise I, Wangensteen L, Steer CJ, McIvor RS, Largaespada DA, Wang X, Ekker SC. A method for lifelong genetic manipulation of regenerating hepatocytes in mouse Cell Research. 18: S31-S31. DOI: 10.1038/Cr.2008.121  0.619
2008 McIvor RS, Low WC, Hackett PB, Whitley CB. 70. Gene therapy for lysosomal storage disorders Molecular Genetics and Metabolism. 93: 32. DOI: 10.1016/J.Ymgme.2007.10.082  0.327
2008 McIvor RS, Wolf DA, Nan Z, Quito M, Podetz-Pedersen K, Whitley CB, Low WC, Belur LR. 69. Gene therapy of mucopolysaccharidosis type I: Intraventricular administration of adeno-associated virus vector transducing the human alpha-l-iduronidase gene in a murine model of the disease Molecular Genetics and Metabolism. 93: 31. DOI: 10.1016/J.Ymgme.2007.10.081  0.43
2008 Hackett P, Podetz-Pedersen K, Bell J, Aronovich E, Kren B, Whitley C, Driessen W, Sullivan S, McIvor RS. 37. Comparison of gene expression in vivo from Sleeping Beauty transposons after hydrodynamic delivery or condensation by polyethylenimine and cationic lipids Molecular Genetics and Metabolism. 93: 23. DOI: 10.1016/J.Ymgme.2007.10.049  0.439
2008 Belur L, Fairbanks C, Vulchanova L, Podetz-Pedersen K, Low W, McIvor RS. 7. Gene delivery and biodistribution in the brain and spinal cord following intrathecal administration of adeno-associated virus serotype 5 vector Molecular Genetics and Metabolism. 93: 15-16. DOI: 10.1016/J.Ymgme.2007.10.019  0.324
2008 Aronovich E, Bell J, Belur L, Gunther R, Brenda K, Kahn S, Schachern P, Ehlenfeldt R, Gupta P, Carlson C, Whitley C, McIvor RS, Hackett P. 4. Sleeping Beauty transposon-mediated long-term α-l-iduronidase expression and correction of lysosomal pathology in NOD/SCID mice with MPS I Molecular Genetics and Metabolism. 93: 15. DOI: 10.1016/J.Ymgme.2007.10.016  0.374
2007 Bell JB, Podetz-Pedersen KM, Aronovich EL, Belur LR, McIvor RS, Hackett PB. Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection. Nature Protocols. 2: 3153-65. PMID 18079715 DOI: 10.1038/Nprot.2007.471  0.498
2007 Belur LR, Podetz-Pedersen K, Frandsen J, McIvor RS. Lung-directed gene therapy in mice using the nonviral Sleeping Beauty transposon system. Nature Protocols. 2: 3146-52. PMID 18079714 DOI: 10.1038/Nprot.2007.460  0.457
2007 Wilber A, Linehan JL, Tian X, Woll PS, Morris JK, Belur LR, McIvor RS, Kaufman DS. Efficient and stable transgene expression in human embryonic stem cells using transposon-mediated gene transfer. Stem Cells (Dayton, Ohio). 25: 2919-27. PMID 17673526 DOI: 10.1634/Stemcells.2007-0026  0.762
2007 Gori JL, Podetz-Pedersen K, Swanson D, Karlen AD, Gunther R, Somia NV, McIvor RS. Protection of mice from methotrexate toxicity by ex vivo transduction using lentivirus vectors expressing drug-resistant dihydrofolate reductase. The Journal of Pharmacology and Experimental Therapeutics. 322: 989-97. PMID 17586722 DOI: 10.1124/Jpet.107.123414  0.473
2007 Zayed H, Xia L, Yerich A, Yant SR, Kay MA, Puttaraju M, McGarrity GJ, Wiest DL, McIvor RS, Tolar J, Blazar BR. Correction of DNA protein kinase deficiency by spliceosome-mediated RNA trans-splicing and sleeping beauty transposon delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1273-9. PMID 17457319 DOI: 10.1038/Sj.Mt.6300178  0.438
2007 Wilber A, Wangensteen KJ, Chen Y, Zhuo L, Frandsen JL, Bell JB, Chen ZJ, Ekker SC, McIvor RS, Wang X. Messenger RNA as a source of transposase for sleeping beauty transposon-mediated correction of hereditary tyrosinemia type I. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1280-7. PMID 17440442 DOI: 10.1038/Sj.Mt.6300160  0.711
2007 Aronovich EL, Bell JB, Belur LR, Gunther R, Koniar B, Erickson DC, Schachern PA, Matise I, McIvor RS, Whitley CB, Hackett PB. Prolonged expression of a lysosomal enzyme in mouse liver after Sleeping Beauty transposon-mediated gene delivery: implications for non-viral gene therapy of mucopolysaccharidoses. The Journal of Gene Medicine. 9: 403-15. PMID 17407189 DOI: 10.1002/Jgm.1028  0.482
2007 Tolar J, Nauta AJ, Osborn MJ, Panoskaltsis Mortari A, McElmurry RT, Bell S, Xia L, Zhou N, Riddle M, Schroeder TM, Westendorf JJ, McIvor RS, Hogendoorn PC, Szuhai K, Oseth L, et al. Sarcoma derived from cultured mesenchymal stem cells. Stem Cells (Dayton, Ohio). 25: 371-9. PMID 17038675 DOI: 10.1634/Stemcells.2005-0620  0.401
2007 Belur L, deMorest Z, Whitley CB, Low WC, McIvor RS. 11 Adeno-associated virus vector-mediated gene therapy in a murine model of mucopolysaccharidosis type I Molecular Genetics and Metabolism. 92: 13-14. DOI: 10.1016/J.Ymgme.2007.08.016  0.407
2006 Score PR, Belur LR, Frandsen JL, Geurts JL, Yamaguchi T, Somia NV, Hackett PB, Largaespada DA, McIvor RS. Erratum to "Sleeping Beauty-Mediated Transposition and Long-Term Expression in Vivo: Use of the LoxP/Cre Recombinase System to Distinguish Transposition-Specific Expression". Molecular Therapy : the Journal of the American Society of Gene Therapy. 14: 149. PMID 28192690 DOI: 10.1016/J.Ymthe.2006.03.011  0.793
2006 Balciunas D, Wangensteen KJ, Wilber A, Bell J, Geurts A, Sivasubbu S, Wang X, Hackett PB, Largaespada DA, McIvor RS, Ekker SC. Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. Plos Genetics. 2: e169. PMID 17096595 DOI: 10.1371/Journal.Pgen.0020169  0.712
2006 Geurts AM, Wilber A, Carlson CM, Lobitz PD, Clark KJ, Hackett PB, McIvor RS, Largaespada DA. Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. Bmc Biotechnology. 6: 30. PMID 16800892 DOI: 10.1186/1472-6750-6-30  0.722
2006 O'Brien TA, Tuong DT, Basso LM, McIvor RS, Orchard PJ. Coexpression of the uracil phosphoribosyltransferase gene with a chimeric human nerve growth factor receptor/cytosine deaminase fusion gene, using a single retroviral vector, augments cytotoxicity of transduced human T cells exposed to 5-fluorocytosine. Human Gene Therapy. 17: 518-30. PMID 16716109 DOI: 10.1089/Hum.2006.17.518  0.49
2006 Zayed H, McIvor RS, Wiest DL, Blazar BR. In vitro functional correction of the mutation responsible for murine severe combined immune deficiency by small fragment homologous replacement. Human Gene Therapy. 17: 158-66. PMID 16454649 DOI: 10.1089/Hum.2006.17.158  0.408
2006 Tolar J, O'shaughnessy MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell S, Riddle M, McIvor RS, Yant SR, Kay MA, Krause D, Verfaillie CM, Blazar BR. Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells. Blood. 107: 4182-8. PMID 16410448 DOI: 10.1182/Blood-2005-08-3289  0.433
2006 Wilber A, Frandsen JL, Geurts JL, Largaespada DA, Hackett PB, McIvor RS. RNA as a source of transposase for Sleeping Beauty-mediated gene insertion and expression in somatic cells and tissues. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 625-30. PMID 16368272 DOI: 10.1016/J.Ymthe.2005.10.014  0.742
2006 Score PR, Belur LR, Frandsen JL, Geurts JL, Guerts JL, Yamaguchi T, Somia NV, Hackett PB, Largaespada DA, McIvor RS. Sleeping Beauty-mediated transposition and long-term expression in vivo: use of the LoxP/Cre recombinase system to distinguish transposition-specific expression. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 617-24. PMID 16356773 DOI: 10.1016/J.Ymthe.2005.10.015  0.829
2006 Huang X, Wilber AC, Bao L, Tuong D, Tolar J, Orchard PJ, Levine BL, June CH, McIvor RS, Blazar BR, Zhou X. Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system. Blood. 107: 483-91. PMID 16189271 DOI: 10.1182/Blood-2005-05-2133  0.75
2006 Seth G, McIvor RS, Hu WS. 17Beta-hydroxysteroid dehydrogenase type 7 (Hsd17b7) reverts cholesterol auxotrophy in NS0 cells. Journal of Biotechnology. 121: 241-52. PMID 16126295 DOI: 10.1016/J.Jbiotec.2005.07.017  0.351
2006 Zhou X, Huang X, Kang J, Guo H, Choi S, Bassi P, Zhou TC, Milone MC, Levine BL, June CH, McIvor RS, Wagner JE, Blazar BR. Sleeping Beauty (SB) Transposon Mediated Umbilical Cord Blood (UCB) T Cell Therapy for Refractory Acute Lymphoblastic Leukemia (ALL). Blood. 108: 722-722. DOI: 10.1182/Blood.V108.11.722.722  0.419
2006 Tolar J, Nauta AJ, Osborn MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell S, Xia L, Zhou N, Riddle M, Schroeder TM, Westendorf JJ, McIvor RS, Hogendoom PC, Szuhai K, Oseth L, et al. Osteosarcoma Derived from Cultured Mesenchymal Stem Cells. Blood. 108: 2554-2554. DOI: 10.1182/Blood.V108.11.2554.2554  0.398
2006 Wilber A, Wangensteen KJ, Chen Y, Zhou L, Frandsen JL, Bell J, Chen Z, Ekker SC, McIvor RS, Wang X. 405. Correction of the Murine Model of Hereditary Tyrosinemia Type I Using Messenger RNA as a Source of Transposase for Sleeping Beauty Mediated Integration of the FAH Gene Molecular Therapy. 13: S155-S156. DOI: 10.1016/J.Ymthe.2006.08.468  0.742
2006 Balciunas D, Wilber A, Wangensteen K, Bell J, Geurts A, Hackett PB, Largaespada DA, McIvor RS, Ekker SC. 385. Tol2 Transposon as a Gene Therapy Vector: Characterization, Optimization and Correction of Hereditary Tyrosinemia Type 1 in Mouse Molecular Therapy. 13: S147. DOI: 10.1016/J.Ymthe.2006.08.446  0.711
2006 Podetz-Pedersen KM, Bell JB, Steele TW, Frandsen JL, Shier TW, McIvor RS, Hackett PB. 181. Quantitative Evaluation of Long Term Gene Expression In Vivo after Delivery of Polyethylenimine-Conjugated Sleeping Beauty Transposon DNA Molecular Therapy. 13: S70. DOI: 10.1016/J.Ymthe.2006.08.205  0.489
2006 Wilber A, Linehan JL, Tian X, McIvor RS, Kaufman DS. 95. Effective Genetic Engineering of Human Embryonic Stem Cells Using the Sleeping Beauty Transposon System Molecular Therapy. 13: S39. DOI: 10.1016/J.Ymthe.2006.08.114  0.749
2006 Aronnovich EL, Bell JB, Gunther R, Koniar B, Frantz A, Matise I, McIvor RS, Whitley CB, Hackett PB. 997. Immune-Mediated Loss of Transgene Expression in Mouse Liver Following Transposon Delivery Molecular Therapy. 13: S384. DOI: 10.1016/J.Ymthe.2006.08.1090  0.537
2005 Carlson CM, Frandsen JL, Kirchhof N, McIvor RS, Largaespada DA. Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse. Proceedings of the National Academy of Sciences of the United States of America. 102: 17059-64. PMID 16286660 DOI: 10.1073/Pnas.0502974102  0.5
2005 Wilber A, Frandsen JL, Wangensteen KJ, Ekker SC, Wang X, McIvor RS. Dynamic gene expression after systemic delivery of plasmid DNA as determined by in vivo bioluminescence imaging. Human Gene Therapy. 16: 1325-32. PMID 16259566 DOI: 10.1089/Hum.2005.16.1325  0.749
2005 Hackett PB, Ekker SC, Largaespada DA, McIvor RS. Sleeping beauty transposon-mediated gene therapy for prolonged expression. Advances in Genetics. 54: 189-232. PMID 16096013 DOI: 10.1016/S0065-2660(05)54009-4  0.513
2005 Essner JJ, McIvor RS, Hackett PB. Awakening gene therapy with Sleeping Beauty transposons. Current Opinion in Pharmacology. 5: 513-9. PMID 16084771 DOI: 10.1016/J.Coph.2005.04.015  0.407
2005 Osborn MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell SK, Vignali DA, Ryan MD, Wilber AC, McIvor RS, Tolar J, Blazar BR. A picornaviral 2A-like sequence-based tricistronic vector allowing for high-level therapeutic gene expression coupled to a dual-reporter system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 569-74. PMID 15964244 DOI: 10.1016/J.Ymthe.2005.04.013  0.695
2005 Tolar J, Osborn M, Bell S, McElmurry R, Xia L, Riddle M, Panoskaltsis-Mortari A, Jiang Y, McIvor RS, Contag CH, Yant SR, Kay MA, Verfaillie CM, Blazar BR. Real-time in vivo imaging of stem cells following transgenesis by transposition. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 42-8. PMID 15963919 DOI: 10.1016/J.Ymthe.2005.02.023  0.466
2005 Belur LR, James RI, May C, Diers MD, Swanson D, Gunther R, McIvor RS. Methotrexate preconditioning allows sufficient engraftment to confer drug resistance in mice transplanted with marrow expressing drug-resistant dihydrofolate reductase activity. The Journal of Pharmacology and Experimental Therapeutics. 314: 668-74. PMID 15857949 DOI: 10.1124/Jpet.104.082982  0.341
2005 Zhang JL, Cai J, Jackson JD, Kuszynski CA, Walls S, McIvor RS, Fox IJ. Long-term transgene expression and survival of transgene-expressing grafts following lentivirus transduction of bone marrow side population cells. Transplantation. 79: 882-8. PMID 15849539 DOI: 10.1097/01.Tp.0000148915.65427.16  0.456
2005 Ohlfest JR, Frandsen JL, Fritz S, Lobitz PD, Perkinson SG, Clark KJ, Nelsestuen G, Key NS, McIvor RS, Hackett PB, Largaespada DA. Phenotypic correction and long-term expression of factor VIII in hemophilic mice by immunotolerization and nonviral gene transfer using the Sleeping Beauty transposon system. Blood. 105: 2691-8. PMID 15576475 DOI: 10.1182/Blood-2004-09-3496  0.543
2005 Tolar J, Osborn MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell S, Xia L, Riddle M, Schroeder TM, Westendorf JJ, McIvor RS, Oseth L, Hirsch B, Yant SR, Kay MA, Peister A, et al. Mesenchymal Cancer Cells Can Arise from Ex Vivo Modified Mesenchymal Stem Cells. Blood. 106: 4326-4326. DOI: 10.1182/Blood.V106.11.4326.4326  0.394
2005 Wangensteen KJ, Wilber A, Zeng G, Frandsen JL, McIvor RS, Ekker SC, Wang X. 1068. Luciferase as an In Vivo Reporter for Selective Liver Repopulation in Adult FAH-/- Mice Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.615  0.725
2005 McIvor RS, Somia NV, Converse AD. 826. The Risk of Integration: Characterization and Testing of Cell Lines Engineered for the Study of Insertional Gene Activation Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.369  0.449
2005 Wadman SA, Clark KJ, Hackett PB, McIvor RS, Essner JJ. 347. Long-Term Gene Expression and Phenotypic Correction of FANCC Deficient Lymphoblastoid Cells Using the Sleeping Beauty Transposon System Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.350  0.562
2005 Wilber A, Buckley S, Lakshmipathy U, Frandsen J, Cowan MJ, McIvor RS. 338. Non-Viral Gene Transfer into Hematopoietic Cells of Artemis Deficient ScidA Mice Using the Sleeping BeautyTransposon System|[ast]| Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.341  0.76
2005 Belur L, Lorenzo D, Aronovich E, Low WC, Whitley CB, McIvor RS. 244. AAV Vector-Mediated Gene Therapy of Mucopolysaccharidosis Type I Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.247  0.524
2005 Wilber A, Montoya F, Geurts AM, Largaespada DA, Lakshmipathy U, McIvor RS. 193. Direct Comparison of Integration Efficiency and Stable Gene Expression Mediated by the Sleeping Beauty Transposon System and by the PhiC31 Phage Integrase System in Cultured Human Fibroblasts and in Various Stem Cell Targets Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.196  0.762
2005 Liu LN, Essner JJ, Shivakumar R, Li L, Wadman SA, Clark KJ, Nasevicious A, Fratantoni JC, McIvor RS, Hackett PB. 192. Non-Viral, Long-Term Gene Expression in Hematopoietic Cells Using the Sleeping Beauty Transposon System Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.195  0.549
2004 Converse AD, Belur LR, Gori JL, Liu G, Amaya F, Aguilar-Cordova E, Hackett PB, McIvor RS. Counterselection and co-delivery of transposon and transposase functions for Sleeping Beauty-mediated transposition in cultured mammalian cells. Bioscience Reports. 24: 577-94. PMID 16158196 DOI: 10.1007/S10540-005-2793-9  0.549
2004 Hartung SD, Frandsen JL, Pan D, Koniar BL, Graupman P, Gunther R, Low WC, Whitley CB, McIvor RS. Correction of metabolic, craniofacial, and neurologic abnormalities in MPS I mice treated at birth with adeno-associated virus vector transducing the human alpha-L-iduronidase gene. Molecular Therapy : the Journal of the American Society of Gene Therapy. 9: 866-75. PMID 15194053 DOI: 10.1016/J.Ymthe.2004.03.011  0.797
2004 Tolar J, Bell S, McElmurry R, Xia L, McIvor RS, Yant SR, Kay MA, Contag CH, Verfaillie CM, Blazar BR. Real-Time In Vivo Biodistribution of Multipotent Adult Progenitor Cells (MAPC): Role of the Immune System in MAPC Resistance in Non-Transplanted and Bone Marrow Transplanted Mice. Blood. 104: 507-507. DOI: 10.1182/Blood.V104.11.507.507  0.393
2004 Bell JB, Aronovich EL, Larson-DeBruzzi BE, Koniar BL, Gunther R, Whitley CB, McIvor RS, Hackett PB. 1098. Duration of Expression of Sleeping Beauty Transposase by Hydrodynamic Injection of C57/BL6 Mice Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2005.07.646  0.529
2004 Wilber AC, Frandsen JL, Belur LR, Score PR, Geurts JL, Largaespada DA, Hackett PB, McIvor RS. 1042. RNA as a Source of Transposase for Sleeping Beauty-Mediated Transposition and Long-Term Expression in Somatic Cells and Tissues Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.987  0.824
2004 Ohlfest JR, Perkinson S, Lobitz P, Hasz D, Frandsen J, McIvor RS, Largaespada DA. 963. Development and Testing of Anti-Cancer Sleeping Beauty Transposons for Localized Tumors and Use in Metastasis Suppression Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.906  0.411
2004 Aronovich EL, Bell JB, Belur LR, Fransden JL, Gunther R, Koniar B, Erickson DCC, McIvor RS, Hackett PB, Whitley CB. 871. Long-Term Expression of Sleeping Beauty Transposon in the Murine Model of Mucopolysaccharidosis (MPS) Type VII Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.778  0.512
2004 Score PR, Frandsen JL, Geurts JL, Hackett PB, Largaespada DA, McIvor RS. 823. Use of a Cre Recombinase Silencing Strategy to Characterize Sleeping Beauty-Mediated Transposition In Vivo Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.720  0.829
2004 Frandsen JL, Swanson D, McIvor RS. 279. Methotrexate Chemotherapy of L1210 Leukemia in Mice Transplanted with Transgenic Marrow Expressing Drug-Resistant Dihydrofolate Reductase Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.217  0.4
2004 Ohlfest JR, Perkinson S, Lobitz P, Frandsen J, McIvor RS, Hackett P, Clark K, Essner J, Key N, Largaespada DA. 165. Long-term factor VIII expression and phenotypic correction in a murine model of hemophilia A achieved by immunosuppression and non-viral gene transfer using the sleeping beauty transposon Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.125  0.532
2004 Converse AD, Somia NV, McIvor RS. 7. The Risk of Integration: Cell Lines for Determining the Frequency and Character of Vector-Mediated Insertional Gene Activation Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.05.088  0.507
2003 Lewis VA, Basso L, Blake N, Salo J, Lund TC, McIvor RS, Orchard PJ. Human nerve growth factor receptor and cytosine deaminase fusion genes. Human Gene Therapy. 14: 1009-16. PMID 12869218 DOI: 10.1089/104303403766682269  0.408
2003 Pineda P, Kanter A, McIvor RS, Benkovic SJ, Rosowsky A, Wagner CR. Dihydrofolate reductase mutant with exceptional resistance to methotrexate but not to trimetrexate. Journal of Medicinal Chemistry. 46: 2816-8. PMID 12825924 DOI: 10.1021/Jm034057I  0.337
2003 Sweeney CL, Frandsen JL, Verfaillie CM, McIvor RS. Trimetrexate inhibits progression of the murine 32Dp210 model of chronic myeloid leukemia in animals expressing drug-resistant dihydrofolate reductase. Cancer Research. 63: 1304-10. PMID 12649191  0.691
2002 Orchard PJ, Blazar BR, Burger S, Levine B, Basso L, Nelson DM, Gordon K, McIvor RS, Wagner JE, Miller JS. Clinical-scale selection of anti-CD3/CD28-activated T cells after transduction with a retroviral vector expressing herpes simplex virus thymidine kinase and truncated nerve growth factor receptor. Human Gene Therapy. 13: 979-88. PMID 12031130 DOI: 10.1089/10430340252939087  0.401
2002 Sweeney CL, Diers MD, Frandsen JL, Gunther R, Verfaillie CM, McIvor RS. Methotrexate exacerbates tumor progression in a murine model of chronic myeloid leukemia. The Journal of Pharmacology and Experimental Therapeutics. 300: 1075-84. PMID 11861818 DOI: 10.1124/Jpet.300.3.1075  0.727
2002 Warlick CA, Diers MD, Wagner JE, McIvor RS. In vivo selection of antifolate-resistant transgenic hematopoietic stem cells in a murine bone marrow transplant model. The Journal of Pharmacology and Experimental Therapeutics. 300: 50-6. PMID 11752096 DOI: 10.1124/Jpet.300.1.50  0.459
2000 McIvor RS, Ando D, Breakefield XO, Buckley R, Chow L, Deisseroth A, Greenblatt J, Mickelson C. Prenatal gene transfer: Scientific, medical, and ethical issues: A report of the recombinant DNA advisory committee Human Gene Therapy. 11: 1211-1229. PMID 11660775 DOI: 10.1089/10430340050015257  0.35
2000 Pan D, Aronovich E, McIvor RS, Whitley CB. Retroviral vector design studies toward hematopoietic stem cell gene therapy for mucopolysaccharidosis type I. Gene Therapy. 7: 1875-83. PMID 11110421 DOI: 10.1038/sj.gt.3301298  0.47
2000 Kaemmerer WF, Reddy RG, Warlick CA, Hartung SD, McIvor RS, Low WC. In vivo transduction of cerebellar Purkinje cells using adeno-associated virus vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 2: 446-57. PMID 11082318 DOI: 10.1006/Mthe.2000.0134  0.773
2000 James RI, Warlick CA, Diers MD, Gunther R, McIvor RS. Mild preconditioning and low-level engraftment confer methotrexate resistance in mice transplanted with marrow expressing drug-resistant dihydrofolate reductase activity. Blood. 96: 1334-41. PMID 10942375 DOI: 10.1182/Blood.V96.4.1334  0.424
2000 Pan D, Jonsson JJ, Braun SE, McIvor RS, Whitley CB. "Supercharged Cells" for delivery of recombinant human iduronate-2-sulfatase. Molecular Genetics and Metabolism. 70: 170-8. PMID 10924271 DOI: 10.1006/Mgme.2000.3012  0.459
2000 Warlick CA, Sweeney CL, McIvor RS. Maintenance of differential methotrexate toxicity between cells expressing drug-resistant and wild-type dihydrofolate reductase activities in the presence of nucleosides through nucleoside transport inhibition. Biochemical Pharmacology. 59: 141-51. PMID 10810448 DOI: 10.1016/S0006-2952(99)00311-1  0.717
1999 McIvor RS. Gene therapy of genetic diseases and cancer. Pediatric Transplantation. 3: 116-21. PMID 10587981 DOI: 10.1034/J.1399-3046.1999.00050.X  0.502
1999 Hartung SD, Reddy RG, Whitley CB, McIvor RS. Enzymatic correction and cross-correction of mucopolysaccharidosis type I fibroblasts by adeno-associated virus-mediated transduction of the alpha-L-iduronidase gene. Human Gene Therapy. 10: 2163-72. PMID 10498248 DOI: 10.1089/10430349950017158  0.81
1999 Verfaillie CM, McIvor RS, Zhao RC. Gene therapy for chronic myelogenous leukemia. Molecular Medicine Today. 5: 359-66. PMID 10431169 DOI: 10.1016/S1357-4310(99)01507-5  0.426
1998 Sutton C, McIvor RS, Vagt M, Doggett B, Kapur RP. Methotrexate-resistant form of dihydrofolate reductase protects transgenic murine embryos from teratogenic effects of methotrexate. Pediatric and Developmental Pathology : the Official Journal of the Society For Pediatric Pathology and the Paediatric Pathology Society. 1: 503-12. PMID 9724337 DOI: 10.1007/S100249900069  0.417
1997 Zhao RC, McIvor RS, Griffin JD, Verfaillie CM. Gene therapy for chronic myelogenous leukemia (CML): a retroviral vector that renders hematopoietic progenitors methotrexate-resistant and CML progenitors functionally normal and nontumorigenic in vivo. Blood. 90: 4687-98. PMID 9389683 DOI: 10.1182/Blood.V90.12.4687  0.485
1996 Braun SE, Pan D, Aronovich EL, Jonsson JJ, McIvor RS, Whitley CB. Preclinical studies of lymphocyte gene therapy for mild Hunter syndrome (mucopolysaccharidosis type II). Human Gene Therapy. 7: 283-90. PMID 8835216 DOI: 10.1089/Hum.1996.7.3-283  0.483
1995 Nelson DM, Butters KA, Markert ML, Reinsmoen NL, McIvor RS. Correction of proliferative responses in purine nucleoside phosphorylase (PNP)-deficient T lymphocytes by retroviral-mediated PNP gene transfer and expression. Journal of Immunology (Baltimore, Md. : 1950). 154: 3006-14. PMID 7876563  0.405
1995 Jonsson JJ, Habel DE, McIvor RS. Retrovirus-mediated transduction of an engineered intron-containing purine nucleoside phosphorylase gene. Human Gene Therapy. 6: 611-23. PMID 7578398 DOI: 10.1089/Hum.1995.6.5-611  0.454
1994 Morris JA, McIvor RS. Saturation mutagenesis at dihydrofolate reductase codons 22 and 31. A variety of amino acid substitutions conferring methotrexate resistance. Biochemical Pharmacology. 47: 1207-20. PMID 8161350 DOI: 10.1016/0006-2952(94)90393-X  0.33
1994 Jonsson JJ, Converse A, McIvor RS. An enhancer in the first intron of the human purine nucleoside phosphorylase-encoding gene. Gene. 140: 187-93. PMID 8144026  0.359
1993 Braun SE, Aronovich EL, Anderson RA, Crotty PL, McIvor RS, Whitley CB. Metabolic correction and cross-correction of mucopolysaccharidosis type II (Hunter syndrome) by retroviral-mediated gene transfer and expression of human iduronate-2-sulfatase. Proceedings of the National Academy of Sciences of the United States of America. 90: 11830-4. PMID 8265633  0.363
1993 Vinh DB, McIvor RS. Selective expression of methotrexate-resistant dihydrofolate reductase (DHFR) activity in mice transduced with DHFR retrovirus and administered methotrexate. The Journal of Pharmacology and Experimental Therapeutics. 267: 989-96. PMID 8246174  0.368
1992 Jonsson JJ, Foresman MD, Wilson N, McIvor RS. Intron requirement for expression of the human purine nucleoside phosphorylase gene. Nucleic Acids Research. 20: 3191-8. PMID 1620616  0.41
1992 Thompson K, Vinh DB, McIvor RS. Assay for expression of methotrexate-resistant dihydrofolate reductase activity in the presence of drug-sensitive enzyme. Journal of Pharmacological and Toxicological Methods. 28: 167-73. PMID 1489988 DOI: 10.1016/1056-8719(92)90079-G  0.381
1992 Foresman MD, Nelson DM, McIvor RS. Correction of purine nucleoside phosphorylase deficiency by retroviral-mediated gene transfer in mouse S49 T cell lymphoma: a model for gene therapy of T cell immunodeficiency. Human Gene Therapy. 3: 625-31. PMID 1482702 DOI: 10.1089/Hum.1992.3.6-625  0.552
1992 Nelson DM, Foresman MD, Ronnei BJ, McIvor RS. Isolation and expression of a murine purine nucleoside phosphorylase-encoding cDNA and sequence similarity with the human message. Gene. 113: 215-21. PMID 1374046 DOI: 10.1016/0378-1119(92)90398-9  0.409
1991 Jonsson JJ, McIvor RS. Herpes simplex virus thymidine kinase enzymatic assay in transient transfection experiments using thymidine kinase-deficient cells. Analytical Biochemistry. 199: 232-7. PMID 1667455 DOI: 10.1016/0003-2697(91)90095-B  0.449
1990 McIvor RS. Deletion in a recombinant retroviral vector resulting from a cryptic splice donor signal in the Moloney leukemia virus envelope gene. Virology. 176: 652-5. PMID 2111958 DOI: 10.1016/0042-6822(90)90039-t  0.306
1987 McIvor RS, Johnson MJ, Miller AD, Pitts S, Williams SR, Valerio D, Martin DW, Verma IM. Human purine nucleoside phosphorylase and adenosine deaminase: gene transfer into cultured cells and murine hematopoietic stem cells by using recombinant amphotropic retroviruses. Molecular and Cellular Biology. 7: 838-46. PMID 3102947 DOI: 10.1128/MCB.7.2.838  0.37
1987 Williams SR, Gekeler V, McIvor RS, Martin DW. A human purine nucleoside phosphorylase deficiency caused by a single base change. The Journal of Biological Chemistry. 262: 2332-8. PMID 3029074  0.389
1985 McIvor RS, Wohlhueter RM, Plagemann PP. Uridine phosphorylase from Novikoff rat hepatoma cells: purification, kinetic properties, and its role in uracil anabolism. Journal of Cellular Physiology. 122: 397-404. PMID 2981897 DOI: 10.1002/Jcp.1041220309  0.313
1984 Valeric D, McIvor RS, Williams SR, Duyvesteyn MGC, van Ormondt H, van der Eb AJ, Martin DW. Cloning of human adenosine deaminase cDNA and expression in mouse cells Gene. 31: 147-153. PMID 6526272 DOI: 10.1016/0378-1119(84)90205-1  0.311
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