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Deborah A. Lannigan - Publications

Affiliations: 
University of Virginia, Charlottesville, VA 
Area:
Cell Biology, Molecular Biology, Biochemistry
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46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Wright EB, Lannigan DA. Therapeutic targeting of p90 ribosomal S6 kinase. Frontiers in Cell and Developmental Biology. 11: 1297292. PMID 38169775 DOI: 10.3389/fcell.2023.1297292  0.413
2022 Lannigan DA. ERK1/2-RSK2 Signaling in Regulation of ERα -Mediated Responses. Endocrinology. PMID 35880639 DOI: 10.1210/endocr/bqac106  0.406
2022 Wright EB, Lannigan DA. ERK1/2-RSK regulation of oestrogen homeostasis. The Febs Journal. PMID 35176205 DOI: 10.1111/febs.16407  0.412
2020 Ludwik KA, Lannigan DA. RSK2 and ERα comrades-in-arms in homeostasis and transformation. Molecular & Cellular Oncology. 7: 1825916. PMID 33235919 DOI: 10.1080/23723556.2020.1825916  0.414
2020 Ludwik KA, Sandusky ZM, Stauffer KM, Li Y, Boyd KL, O'Doherty GA, Stricker TP, Lannigan DA. RSK2 Maintains Adult Estrogen Homeostasis by Inhibiting ERK1/2-Mediated Degradation of Estrogen Receptor Alpha. Cell Reports. 32: 107931. PMID 32697984 DOI: 10.1016/J.Celrep.2020.107931  0.519
2020 Kim S, Li Y, Lin L, Sayasith PR, Tarr AT, Wright EB, Yasmin S, Lannigan DA, O'Doherty GA. Synthesis and biological evaluation of 4'-substituted kaempfer-3-ols. The Journal of Organic Chemistry. PMID 32056430 DOI: 10.1021/Acs.Joc.9B03461  0.311
2020 Li Y, Seber P, Wright EB, Yasmin S, Lannigan DA, O'Doherty GA. The affinity of RSK for cylitol analogues of SL0101 is critically dependent on the B-ring C-4'-hydroxy. Chemical Communications (Cambridge, England). PMID 32048692 DOI: 10.1039/D0Cc00128G  0.308
2020 Li Y, Sandusky ZM, Vemula R, Zhang Q, Wu B, Fukuda S, Li M, Lannigan DA, O'Doherty GA. Regioselective Synthesis of a -4'' Carbamate,-6'' -Pr Substituted Cyclitol Analogue of SL0101. Organic Letters. PMID 32009414 DOI: 10.1021/Acs.Orglett.0C00042  0.329
2018 Ludwik KA, McDonald OG, Brenin DR, Lannigan DA. ERα-mediated nuclear sequestration of RSK2 is required for ER+ breast cancer tumorigenesis. Cancer Research. PMID 29351904 DOI: 10.1158/0008-5472.Can-17-2063  0.419
2017 Sowder M, Ludwik K, Pasic L, Brenin, Stricker T, Macara I, Lannigan D. Abstract P1-06-05: Breast cancer organoid cultures preserve intra-tumor heterogeneity and reveal intrinsically resistant phenotypes to standard chemotherapies Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-P1-06-05  0.331
2016 Ludwik KA, Campbell JP, Li M, Li Y, Sandusky ZM, Pasic L, Sowder ME, Brenin DR, Pietenpol JA, O'Doherty GA, Lannigan DA. Development of a RSK Inhibitor as a Novel Therapy for Triple Negative Breast Cancer. Molecular Cancer Therapeutics. PMID 27528706 DOI: 10.1158/1535-7163.Mct-16-0106  0.44
2016 Ludwik KA, Lannigan DA. Ribosomal S6 kinase (RSK) modulators: a patent review. Expert Opinion On Therapeutic Patents. PMID 27410995 DOI: 10.1080/13543776.2016.1212839  0.39
2015 Li M, Li Y, Mrozowski RM, Sandusky ZM, Shan M, Song X, Wu B, Zhang Q, Lannigan DA, O'Doherty GA. Synthesis and Structure-Activity Relationship Study of 5a-Carbasugar Analogues of SL0101. Acs Medicinal Chemistry Letters. 6: 95-9. PMID 25589938 DOI: 10.1021/Ml5004525  0.403
2015 Ludwik K, Lannigan D. Abstract 3461: RSK2 is a driver of estrogen receptor positive breast cancer Cancer Research. 75: 3461-3461. DOI: 10.1158/1538-7445.Am2015-3461  0.453
2014 Mrozowski RM, Sandusky ZM, Vemula R, Wu B, Zhang Q, Lannigan DA, O'Doherty GA. De novo synthesis and biological evaluation of C6″-substituted C4″-amide analogues of SL0101. Organic Letters. 16: 5996-9. PMID 25372628 DOI: 10.1021/Ol503012K  0.318
2012 Mrozowski RM, Vemula R, Wu B, Zhang Q, Schroeder BR, Hilinski MK, Clark DE, Hecht SM, O'Doherty GA, Lannigan DA. Improving the affinity of SL0101 for RSK using structure-based design. Acs Medicinal Chemistry Letters. 4: 175-179. PMID 23519677 DOI: 10.1021/Ml300298V  0.416
2012 Utepbergenov D, Derewenda U, Olekhnovich N, Szukalska G, Banerjee B, Hilinski MK, Lannigan DA, Stukenberg PT, Derewenda ZS. Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor. Biochemistry. 51: 6499-510. PMID 22846040 DOI: 10.1021/Bi300620C  0.385
2012 Hilinski MK, Mrozowski RM, Clark DE, Lannigan DA. Analogs of the RSK inhibitor SL0101: optimization of in vitro biological stability. Bioorganic & Medicinal Chemistry Letters. 22: 3244-7. PMID 22464132 DOI: 10.1016/J.Bmcl.2012.03.033  0.348
2011 Pasic L, Eisinger-Mathason TS, Velayudhan BT, Moskaluk CA, Brenin DR, Macara IG, Lannigan DA. Sustained activation of the HER1-ERK1/2-RSK signaling pathway controls myoepithelial cell fate in human mammary tissue. Genes & Development. 25: 1641-53. PMID 21828273 DOI: 10.1101/Gad.2025611  0.419
2011 Andreani A, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Varoli L, Lannigan D, Smith J, Scudiero D, Kondapaka S, Shoemaker RH. Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors European Journal of Medicinal Chemistry. 46: 4311-4323. PMID 21794960 DOI: 10.1016/J.Ejmech.2011.07.001  0.403
2010 Groehler AL, Lannigan DA. A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA. The Journal of Cell Biology. 190: 575-86. PMID 20733054 DOI: 10.1083/Jcb.201002124  0.65
2010 Eisinger-Mathason TS, Andrade J, Lannigan DA. RSK in tumorigenesis: connections to steroid signaling. Steroids. 75: 191-202. PMID 20045011 DOI: 10.1016/J.Steroids.2009.12.010  0.478
2009 Larrea MD, Hong F, Wander SA, da Silva TG, Helfman D, Lannigan D, Smith JA, Slingerland JM. RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility. Proceedings of the National Academy of Sciences of the United States of America. 106: 9268-73. PMID 19470470 DOI: 10.1073/Pnas.0805057106  0.416
2008 Eisinger-Mathason TS, Andrade J, Groehler AL, Clark DE, Muratore-Schroeder TL, Pasic L, Smith JA, Shabanowitz J, Hunt DF, Macara IG, Lannigan DA. Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival. Molecular Cell. 31: 722-36. PMID 18775331 DOI: 10.1016/J.Molcel.2008.06.025  0.643
2008 Flynn JM, Lannigan DA, Clark DE, Garner MH, Cammarata PR. RNA suppression of ERK2 leads to collapse of mitochondrial membrane potential with acute oxidative stress in human lens epithelial cells American Journal of Physiology - Endocrinology and Metabolism. 294: E589-E599. PMID 18171912 DOI: 10.1152/Ajpendo.00705.2007  0.383
2007 Smith JA, Maloney DJ, Hecht SM, Lannigan DA. Structural basis for the activity of the RSK-specific inhibitor, SL0101. Bioorganic & Medicinal Chemistry. 15: 5018-34. PMID 17512736 DOI: 10.1016/J.Bmc.2007.03.087  0.366
2006 Nguyen TL, Gussio R, Smith JA, Lannigan DA, Hecht SM, Scudiero DA, Shoemaker RH, Zaharevitz DW. Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore. Bioorganic & Medicinal Chemistry. 14: 6097-105. PMID 16723234 DOI: 10.1016/J.Bmc.2006.05.001  0.389
2006 Smith JA, Maloney DJ, Clark DE, Xu Y, Hecht SM, Lannigan DA. Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK. Bioorganic & Medicinal Chemistry. 14: 6034-42. PMID 16723233 DOI: 10.1016/J.Bmc.2006.05.009  0.409
2006 Xu YM, Smith JA, Lannigan DA, Hecht SM. Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK. Bioorganic & Medicinal Chemistry. 14: 3974-7. PMID 16524738 DOI: 10.1016/J.Bmc.2006.01.066  0.305
2005 De S, Macara IG, Lannigan DA. Novel biosensors for the detection of estrogen receptor ligands. The Journal of Steroid Biochemistry and Molecular Biology. 96: 235-44. PMID 15985367 DOI: 10.1016/J.Jsbmb.2005.04.030  0.328
2005 Clark DE, Errington TM, Smith JA, Frierson HF, Weber MJ, Lannigan DA. The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation Cancer Research. 65: 3108-3116. PMID 15833840 DOI: 10.1158/0008-5472.Can-04-3151  0.327
2005 Smith JA, Poteet-Smith CE, Xu Y, Errington TM, Hecht SM, Lannigan DA. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Research. 65: 1027-34. PMID 15705904  0.392
2003 Henrich LM, Smith JA, Kitt D, Errington TM, Nguyen B, Traish AM, Lannigan DA. Extracellular signal-regulated kinase 7, a regulator of hormone-dependent estrogen receptor destruction. Molecular and Cellular Biology. 23: 5979-88. PMID 12917323 DOI: 10.1128/Mcb.23.17.5979-5988.2003  0.62
2003 Lannigan DA. Estrogen receptor phosphorylation. Steroids. 68: 1-9. PMID 12475718 DOI: 10.1016/S0039-128X(02)00110-1  0.478
2001 Clark DE, Poteet-Smith CE, Smith JA, Lannigan DA. Rsk2 allosterically activates estrogen receptor alpha by docking to the hormone-binding domain. The Embo Journal. 20: 3484-94. PMID 11432835 DOI: 10.1093/Emboj/20.13.3484  0.514
2000 Smith JA, Poteet-Smith CE, Lannigan DA, Freed TA, Zoltoski AJ, Sturgill TW. Creation of a stress-activated p90 ribosomal S6 kinase. The carboxyl-terminal tail of the MAPK-activated protein kinases dictates the signal transduction pathway in which they function Journal of Biological Chemistry. 275: 31588-31593. PMID 10922375 DOI: 10.1074/Jbc.M005892200  0.47
1999 Poteet-Smith CE, Smith JA, Lannigan DA, Freed TA, Sturgill TW. Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family Journal of Biological Chemistry. 274: 22135-22138. PMID 10428774 DOI: 10.1074/Jbc.274.32.22135  0.467
1999 Tatsis N, Lannigan DA, Macara IG. The function of the p190 Rho GTPase-activating protein is controlled by its N-terminal GTP binding domain. The Journal of Biological Chemistry. 273: 34631-8. PMID 9852136 DOI: 10.1074/Jbc.273.51.34631  0.359
1998 Joel PB, Traish AM, Lannigan DA. Estradiol-induced phosphorylation of serine 118 in the estrogen receptor is independent of p42/p44 mitogen-activated protein kinase Journal of Biological Chemistry. 273: 13317-13323. PMID 9582378 DOI: 10.1074/Jbc.273.21.13317  0.488
1998 Joel PB, Smith J, Sturgill TW, Fisher TL, Blenis J, Lannigan DA. pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. Molecular and Cellular Biology. 18: 1978-84. PMID 9528769 DOI: 10.1128/Mcb.18.4.1978  0.489
1996 Bush SM, Folta S, Lannigan DA. Use of the yeast one-hybrid system to screen for mutations in the ligand-binding domain of the estrogen receptor. Steroids. 61: 102-9. PMID 8852826 DOI: 10.1016/0039-128X(95)00200-A  0.34
1995 Joel PB, Traish AM, Lannigan DA. Estradiol and phorbol ester cause phosphorylation of serine 118 in the human estrogen receptor Molecular Endocrinology. 9: 1041-1052. PMID 7476978 DOI: 10.1210/Mend.9.8.7476978  0.364
1993 Lannigan DA, Tomashek JJ, Obourn JD, Notides AC. Analysis of estrogen receptor interaction with tertiary-structured estrogen responsive elements. Biochemical Pharmacology. 45: 1921-8. PMID 8494551 DOI: 10.1016/0006-2952(93)90452-3  0.36
1993 Lannigan DA, Koszewski NJ, Notides AC. Estrogen-responsive elements contain non-B DNA. Molecular and Cellular Endocrinology. 94: 47-54. PMID 8375575 DOI: 10.1016/0303-7207(93)90050-T  0.39
1989 Lannigan DA, Notides AC. Estrogen receptor selectively binds the "coding strand" of an estrogen responsive element. Proceedings of the National Academy of Sciences of the United States of America. 86: 863-7. PMID 2915982 DOI: 10.1073/Pnas.86.3.863  0.363
1988 Lannigan DA, Bennington JB, Cragoe EJ, Knauf PA. Phenamil, an amiloride analogue, inhibits differentiation of Friend murine erythroleukemic cells. The American Journal of Physiology. 254: C122-9. PMID 3422134 DOI: 10.1152/Ajpcell.1988.254.1.C122  0.302
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