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Andrew A. Mehle, Ph.D. - Publications

Affiliations: 
1998-2004 Harvard University, Cambridge, MA, United States 
 2005-2011 University of California, Berkeley, Berkeley, CA, United States 
 2011- Medical Microbiology & Immunology University of Wisconsin, Madison, Madison, WI 
Area:
Virology
Website:
https://medmicro.wisc.edu/people_faculty_profile.php?id=amehle
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45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ranum JN, Ledwith MP, Alnaji FG, Diefenbacher M, Orton R, Sloan E, Güereca M, Feltman EM, Smollett K, da Silva Filipe A, Conley M, Russell AB, Brooke CB, Hutchinson E, Mehle A. Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome. Nucleic Acids Research. PMID 38407436 DOI: 10.1093/nar/gkae133  0.433
2023 Ranum JN, Ledwith MP, Alnaji FG, Diefenbacher M, Orton R, Sloan E, Guereca M, Feltman EM, Smollett K, da Silva Filipe A, Conley M, Russell AB, Brooke CB, Hutchinson E, Mehle A. Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome. Biorxiv : the Preprint Server For Biology. PMID 38168266 DOI: 10.1101/2023.12.12.570638  0.437
2023 King CR, Liu Y, Amato KA, Schaack GA, Mickelson C, Sanders AE, Hu T, Gupta S, Langlois RA, Smith JA, Mehle A. Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection. Cell Host & Microbe. PMID 37652009 DOI: 10.1016/j.chom.2023.08.001  0.322
2023 King CR, Liu Y, Amato KA, Schaack GA, Hu T, Smith JA, Mehle A. Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection. Biorxiv : the Preprint Server For Biology. PMID 36798235 DOI: 10.1101/2023.02.07.527556  0.338
2022 Baker SF, Meistermann H, Tzouros M, Baker A, Golling S, Polster JS, Ledwith MP, Gitter A, Augustin A, Javanbakht H, Mehle A. Alternative splicing liberates a cryptic cytoplasmic isoform of mitochondrial MECR that antagonizes influenza virus. Plos Biology. 20: e3001934. PMID 36542656 DOI: 10.1371/journal.pbio.3001934  0.726
2022 King CR, Mehle A. Retasking of canonical antiviral factors into proviral effectors. Current Opinion in Virology. 56: 101271. PMID 36242894 DOI: 10.1016/j.coviro.2022.101271  0.435
2022 Amato KA, Haddock LA, Braun KM, Meliopoulos V, Livingston B, Honce R, Schaack GA, Boehm E, Higgins CA, Barry GL, Koelle K, Schultz-Cherry S, Friedrich TC, Mehle A. Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks. Nature Communications. 13: 3416. PMID 35701424 DOI: 10.1038/s41467-022-31147-0  0.378
2021 Te Velthuis AJW, Zubkova TG, Shaw M, Mehle A, Boltz D, Gmeinwieser N, Stammer H, Milde J, Müller L, Margitich V. Enisamium reduces influenza virus shedding and improves patient recovery by inhibiting viral RNA polymerase activity. Antimicrobial Agents and Chemotherapy. PMID 33558285 DOI: 10.1128/AAC.02605-20  0.373
2020 Dawson AR, Wilson GM, Freiberger EC, Mondal A, Coon JJ, Mehle A. Phosphorylation controls RNA binding and transcription by the influenza virus polymerase. Plos Pathogens. 16: e1008841. PMID 32881973 DOI: 10.1371/Journal.Ppat.1008841  0.725
2020 King CR, Mehle A. The later stages of viral infection: An undiscovered country of host dependency factors. Plos Pathogens. 16: e1008777. PMID 32841303 DOI: 10.1371/Journal.Ppat.1008777  0.368
2020 Tran V, Ledwith MP, Thamamongood T, Higgins CA, Tripathi S, Chang MW, Benner C, García-Sastre A, Schwemmle M, Boon ACM, Diamond MS, Mehle A. Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs. Nature Microbiology. PMID 32839537 DOI: 10.1038/S41564-020-0778-X  0.552
2020 Dawson AR, Wilson GM, Coon JJ, Mehle A. Post-Translation Regulation of Influenza Virus Replication. Annual Review of Virology. PMID 32453972 DOI: 10.1146/Annurev-Virology-010320-070410  0.545
2019 Schaack GA, Mehle A. Experimental Approaches to Identify Host Factors Important for Influenza Virus. Cold Spring Harbor Perspectives in Medicine. 10. PMID 31871241 DOI: 10.1101/Cshperspect.A038521  0.501
2019 Larson GP, Tran V, Yú S, Caì Y, Higgins CA, Smith DM, Baker SF, Radoshitzky SR, Kuhn JH, Mehle A. EPS8 Facilitates Uncoating of Influenza A Virus. Cell Reports. 29: 2175-2183.e4. PMID 31747592 DOI: 10.1016/J.Celrep.2019.10.064  0.721
2019 Baker SF, Mehle A. ANP32B, or not to be, that is the question for influenza virus. Elife. 8. PMID 31179971 DOI: 10.7554/Elife.48084  0.722
2018 Dawson AR, Mehle A. Flu's cues: Exploiting host post-translational modifications to direct the influenza virus replication cycle. Plos Pathogens. 14: e1007205. PMID 30235357 DOI: 10.1371/Journal.Ppat.1007205  0.537
2018 Baker SF, Ledwith MP, Mehle A. Differential Splicing of ANP32A in Birds Alters Its Ability to Stimulate RNA Synthesis by Restricted Influenza Polymerase. Cell Reports. 24: 2581-2588.e4. PMID 30184493 DOI: 10.1016/J.Celrep.2018.08.012  0.719
2018 Karlsson EA, Meliopoulos VA, Tran V, Savage C, Livingston B, Schultz-Cherry S, Mehle A. Measuring Influenza Virus Infection Using Bioluminescent Reporter Viruses for In Vivo Imaging and In Vitro Replication Assays. Methods in Molecular Biology (Clifton, N.J.). 1836: 431-459. PMID 30151586 DOI: 10.1007/978-1-4939-8678-1_21  0.508
2017 Mondal A, Dawson AR, Potts GK, Freiberger EC, Baker SF, Moser LA, Bernard KA, Coon JJ, Mehle A. Influenza virus recruits host protein kinase C to control assembly and activity of its replication machinery. Elife. 6. PMID 28758638 DOI: 10.7554/Elife.26910  0.788
2017 Czakó R, Vogel L, Lamirande EW, Bock KW, Moore IN, Ellebedy AH, Ahmed R, Mehle A, Subbarao K. In Vivo Imaging of Influenza Virus Infection in Immunized Mice. Mbio. 8. PMID 28559489 DOI: 10.1128/Mbio.00714-17  0.423
2017 Mondal A, Dawson AR, Potts GK, Freiberger EC, Baker SF, Moser LA, Bernard KA, Coon JJ, Mehle A. Author response: Influenza virus recruits host protein kinase C to control assembly and activity of its replication machinery Elife. DOI: 10.7554/Elife.26910.020  0.725
2016 Kirui J, Mondal A, Mehle A. Ubiquitination up-regulates influenza virus polymerase function. Journal of Virology. PMID 27681127 DOI: 10.1128/Jvi.01829-16  0.75
2016 Karlsson EA, Hertz T, Johnson C, Mehle A, Krammer F, Schultz-Cherry S. Obesity Outweighs Protection Conferred by Adjuvanted Influenza Vaccination. Mbio. 7. PMID 27486196 DOI: 10.1128/Mbio.01144-16  0.332
2016 Mehle A. The Avian Influenza Virus Polymerase Brings ANP32A Home to Roost. Cell Host & Microbe. 19: 137-138. PMID 26867171 DOI: 10.1016/J.Chom.2016.01.013  0.475
2015 Tran V, Poole DS, Jeffery JJ, Sheahan TP, Creech D, Yevtodiyenko A, Peat AJ, Francis KP, You S, Mehle A. Multi-Modal Imaging with a Toolbox of Influenza AReporter Viruses. Viruses. 7: 5319-27. PMID 26473913 DOI: 10.3390/V7102873  0.462
2015 Mehle A. Fiat Luc: Bioluminescence Imaging Reveals In Vivo Viral Replication Dynamics Plos Pathogens. 11. PMID 26356297 DOI: 10.1371/Journal.Ppat.1005081  0.454
2015 Mondal A, Potts GK, Dawson AR, Coon JJ, Mehle A. Phosphorylation at the homotypic interface regulates nucleoprotein oligomerization and assembly of the influenza virus replication machinery. Plos Pathogens. 11: e1004826. PMID 25867750 DOI: 10.1371/Journal.Ppat.1004826  0.71
2015 Karlsson EA, Meliopoulos VA, Savage C, Livingston B, Mehle A, Schultz-Cherry S. Visualizing real-time influenza virus infection, transmission and protection in ferrets. Nature Communications. 6: 6378. PMID 25744559 DOI: 10.1038/Ncomms7378  0.475
2014 Striker R, Mehle A. Inhibitors of Peptidyl Proline Isomerases As Antivirals in Hepatitis C and Other Viruses Plos Pathogens. 10. PMID 25375953 DOI: 10.1371/Journal.Ppat.1004428  0.474
2014 Mehle A. Unusual Influenza A Viruses in Bats Viruses. 6: 3438-3449. PMID 25256392 DOI: 10.3390/V6093438  0.515
2014 Poole DS, Yú S, Caì Y, Dinis JM, Müller MA, Jordan I, Friedrich TC, Kuhn JH, Mehle A. Influenza A virus polymerase is a site for adaptive changes during experimental evolution in bat cells. Journal of Virology. 88: 12572-85. PMID 25142579 DOI: 10.1128/Jvi.01857-14  0.55
2014 Kirui J, Bucci MD, Poole DS, Mehle A. Conserved features of the PB2 627 domain impact influenza virus polymerase function and replication. Journal of Virology. 88: 5977-86. PMID 24623411 DOI: 10.1128/Jvi.00508-14  0.562
2013 Tran V, Moser LA, Poole DS, Mehle A. Highly sensitive real-time in vivo imaging of an influenza reporter virus reveals dynamics of replication and spread. Journal of Virology. 87: 13321-9. PMID 24089552 DOI: 10.1128/Jvi.02381-13  0.528
2012 Bhattacharya D, Ansari IH, Mehle A, Striker R. Fluorescence resonance energy transfer-based intracellular assay for the conformation of hepatitis C virus drug target NS5A Journal of Virology. 86: 8277-8286. PMID 22623794 DOI: 10.1128/Jvi.00645-12  0.38
2012 Mehle A, Dugan VG, Taubenberger JK, Doudna JA. Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers. Journal of Virology. 86: 1750-7. PMID 22090127 DOI: 10.1128/Jvi.06203-11  0.644
2010 Mehle A, Doudna JA. A host of factors regulating influenza virus replication. Viruses. 2: 566-73. PMID 21994648 DOI: 10.3390/V2020566  0.65
2009 Mehle A, Doudna JA. Adaptive strategies of the influenza virus polymerase for replication in humans. Proceedings of the National Academy of Sciences of the United States of America. 106: 21312-6. PMID 19995968 DOI: 10.1073/Pnas.0911915106  0.654
2008 Mehle A, Doudna JA. An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase. Cell Host & Microbe. 4: 111-22. PMID 18692771 DOI: 10.1016/J.Chom.2008.06.007  0.656
2007 Mehle A, Wilson H, Zhang C, Brazier AJ, McPike M, Pery E, Gabuzda D. Identification of an APOBEC3G binding site in human immunodeficiency virus type 1 Vif and inhibitors of Vif-APOBEC3G binding. Journal of Virology. 81: 13235-41. PMID 17898068 DOI: 10.1128/Jvi.00204-07  0.572
2007 Gorry PR, Dunfee RL, Mefford ME, Kunstman K, Morgan T, Moore JP, Mascola JR, Agopian K, Holm GH, Mehle A, Taylor J, Farzan M, Wang H, Ellery P, Willey SJ, et al. Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote. Virology. 362: 163-78. PMID 17239419 DOI: 10.1016/J.Virol.2006.11.025  0.57
2006 Mehle A, Thomas ER, Rajendran KS, Gabuzda D. A zinc-binding region in Vif binds Cul5 and determines cullin selection. The Journal of Biological Chemistry. 281: 17259-65. PMID 16636053 DOI: 10.1074/Jbc.M602413200  0.556
2004 Mehle A, Goncalves J, Santa-Marta M, McPike M, Gabuzda D. Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. Genes & Development. 18: 2861-6. PMID 15574592 DOI: 10.1101/Gad.1249904  0.611
2004 Mehle A, Strack B, Ancuta P, Zhang C, McPike M, Gabuzda D. Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathway. The Journal of Biological Chemistry. 279: 7792-8. PMID 14672928 DOI: 10.1074/Jbc.M313093200  0.664
2003 Ancuta P, Rao R, Moses A, Mehle A, Shaw SK, Luscinskas FW, Gabuzda D. Fractalkine preferentially mediates arrest and migration of CD16+ monocytes. The Journal of Experimental Medicine. 197: 1701-7. PMID 12810688 DOI: 10.1084/Jem.20022156  0.513
2002 Gorry PR, Taylor J, Holm GH, Mehle A, Morgan T, Cayabyab M, Farzan M, Wang H, Bell JE, Kunstman K, Moore JP, Wolinsky SM, Gabuzda D. Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate. Journal of Virology. 76: 6277-92. PMID 12021361 DOI: 10.1128/Jvi.76.12.6277-6292.2002  0.777
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