William W. Metcalf - Publications

Affiliations: 
University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
Microbiology Biology

112 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Navarro-Muñoz JC, Selem-Mojica N, Mullowney MW, Kautsar SA, Tryon JH, Parkinson EI, De Los Santos ELC, Yeong M, Cruz-Morales P, Abubucker S, Roeters A, Lokhorst W, Fernandez-Guerra A, Cappelini LTD, Goering AW, ... ... Metcalf WW, et al. A computational framework to explore large-scale biosynthetic diversity. Nature Chemical Biology. PMID 31768033 DOI: 10.1038/s41589-019-0400-9  0.48
2019 Farley KR, Metcalf WW. The streptothricin acetyltransferase (sat) gene as a positive selectable marker for methanogenic archaea. Fems Microbiology Letters. PMID 31605529 DOI: 10.1093/femsle/fnz216  0.52
2019 Zeng Z, Liu XL, Farley KR, Wei JH, Metcalf WW, Summons RE, Welander PV. GDGT cyclization proteins identify the dominant archaeal sources of tetraether lipids in the ocean. Proceedings of the National Academy of Sciences of the United States of America. PMID 31591189 DOI: 10.1073/pnas.1909306116  1
2019 Mand TD, Metcalf WW. Energy Conservation and Hydrogenase Function in Methanogenic Archaea, in Particular the Genus . Microbiology and Molecular Biology Reviews : Mmbr. 83. PMID 31533962 DOI: 10.1128/MMBR.00020-19  1
2019 Parkinson EI, Erb A, Eliot AC, Ju KS, Metcalf WW. Fosmidomycin biosynthesis diverges from related phosphonate natural products. Nature Chemical Biology. PMID 31451762 DOI: 10.1038/s41589-019-0343-1  0.72
2019 Fu H, Goettge MN, Metcalf WW. Biochemical characterization of the methylmercaptopropionate:cob(I)alamin methyltransferase from . Journal of Bacteriology. PMID 30936368 DOI: 10.1128/JB.00130-19  0.64
2019 Petronikolou N, Ortega MA, Borisova SA, Nair SK, Metcalf WW. Molecular basis of Bacillus subtilis ATCC6633 self-resistance to the phosphono-oligopeptide antibiotic rhizocticin. Acs Chemical Biology. PMID 30830751 DOI: 10.1021/acschembio.9b00030  0.64
2018 Mand TD, Kulkarni G, Metcalf WW. Genetic, biochemical, and molecular characterization of mutants lacking three distinct classes of hydrogenase. Journal of Bacteriology. PMID 30012731 DOI: 10.1128/JB.00342-18  1
2018 Kulkarni G, Mand TD, Metcalf WW. Energy Conservation via Hydrogen Cycling in the Methanogenic Archaeon Methanosarcina barkeri. Mbio. 9. PMID 29970471 DOI: 10.1128/mBio.01256-18  1
2018 Goettge MN, Cioni JP, Ju KS, Pallitsch K, Metcalf WW. -PcxL and HpxL are flavin-dependent, oxime-forming N-oxidases in phosphonocystoximic acid biosynthesis in. The Journal of Biological Chemistry. PMID 29540479 DOI: 10.1074/jbc.RA118.001721  0.72
2018 Parkinson EI, Tryon JH, Goering AW, Ju KS, McClure RA, Kemball JD, Zhukovsky S, Labeda DP, Thomson RJ, Kelleher NL, Metcalf WW. Discovery of the tyrobetaine natural products and their biosynthetic gene cluster via metabologenomics. Acs Chemical Biology. PMID 29510029 DOI: 10.1021/acschembio.7b01089  0.72
2016 Labeda DP, Dunlap CA, Rong X, Huang Y, Doroghazi JR, Ju KS, Metcalf WW. Phylogenetic relationships in the family Streptomycetaceae using multi-locus sequence analysis. Antonie Van Leeuwenhoek. PMID 28039547 DOI: 10.1007/s10482-016-0824-0  0.72
2016 McClure RA, Goering AW, Ju KS, Baccile JA, Schroeder FC, Metcalf WW, Thomson RJ, Kelleher NL. Elucidating the rimosamide-detoxin natural product families and their biosynthesis using metabolite/gene cluster correlations. Acs Chemical Biology. PMID 27809474 DOI: 10.1021/acschembio.6b00779  0.72
2016 Price NP, Labeda DP, Naumann TA, Vermillion KE, Bowman MJ, Berhow MA, Metcalf WW, Bischoff KM. Quinovosamycins: new tunicamycin-type antibiotics in which the α, β-1″,11'-linked N-acetylglucosamine residue is replaced by N-acetylquinovosamine. The Journal of Antibiotics. PMID 27189123 DOI: 10.1038/ja.2016.49  0.44
2016 Goering AW, McClure RA, Doroghazi JR, Albright JC, Haverland NA, Zhang Y, Ju KS, Thomson RJ, Metcalf WW, Kelleher NL. Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer. Acs Central Science. 2: 99-108. PMID 27163034 DOI: 10.1021/acscentsci.5b00331  0.72
2016 Labeda DP, Rong X, Huang Y, Doroghazi JR, Ju KS, Metcalf WW. Taxonomic evaluation of species in the Streptomyces hirsutus clade using multi-locus sequence analysis and proposals to reclassify several species in this clade. International Journal of Systematic and Evolutionary Microbiology. PMID 26971011 DOI: 10.1099/ijsem.0.001017  0.44
2015 Smith MW, Davis RE, Youngblut ND, Kärnä T, Herfort L, Whitaker RJ, Metcalf WW, Tebo BM, Baptista AM, Simon HM. Metagenomic evidence for reciprocal particle exchange between the mainstem estuary and lateral bay sediments of the lower Columbia River. Frontiers in Microbiology. 6: 1074. PMID 26483785 DOI: 10.3389/fmicb.2015.01074  1
2015 Blodgett JA, Zhang JK, Yu X, Metcalf WW. Conserved biosynthetic pathways for phosalacine, bialaphos and newly discovered phosphonic acid natural products. The Journal of Antibiotics. PMID 26328935 DOI: 10.1038/ja.2015.77  0.64
2015 Ju KS, Gao J, Doroghazi JR, Wang KA, Thibodeaux CJ, Li S, Metzger E, Fudala J, Su J, Zhang JK, Lee J, Cioni JP, Evans BS, Hirota R, Labeda DP, ... ... Metcalf WW, et al. Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes. Proceedings of the National Academy of Sciences of the United States of America. PMID 26324907 DOI: 10.1073/pnas.1500873112  1
2015 Youngblut ND, Wirth JS, Henriksen JR, Smith M, Simon H, Metcalf WW, Whitaker RJ. Genomic and phenotypic differentiation among Methanosarcina mazei populations from Columbia River sediment. The Isme Journal. PMID 25756680 DOI: 10.1038/ismej.2015.31  1
2015 Fu H, Metcalf WW. Genetic basis for metabolism of methylated sulfur compounds in Methanosarcina species. Journal of Bacteriology. 197: 1515-24. PMID 25691524 DOI: 10.1128/JB.02605-14  0.4
2014 Doroghazi JR, Albright JC, Goering AW, Ju KS, Haines RR, Tchalukov KA, Labeda DP, Kelleher NL, Metcalf WW. A roadmap for natural product discovery based on large-scale genomics and metabolomics. Nature Chemical Biology. 10: 963-8. PMID 25262415 DOI: 10.1038/nchembio.1659  1
2014 Lieber DJ, Catlett J, Madayiputhiya N, Nandakumar R, Lopez MM, Metcalf WW, Buan NR. A multienzyme complex channels substrates and electrons through acetyl-CoA and methane biosynthesis pathways in Methanosarcina. Plos One. 9: e107563. PMID 25232733 DOI: 10.1371/journal.pone.0107563  1
2014 Peterson JR, Labhsetwar P, Ellermeier JR, Kohler PR, Jain A, Ha T, Metcalf WW, Luthey-Schulten Z. Towards a computational model of a methane producing archaeum. Archaea (Vancouver, B.C.). 2014: 898453. PMID 24729742 DOI: 10.1155/2014/898453  1
2014 Yu X, Price NP, Evans BS, Metcalf WW. Purification and characterization of phosphonoglycans from Glycomyces sp. strain NRRL B-16210 and Stackebrandtia nassauensis NRRL B-16338. Journal of Bacteriology. 196: 1768-79. PMID 24584498 DOI: 10.1128/JB.00036-14  1
2014 Cioni JP, Doroghazi JR, Ju KS, Yu X, Evans BS, Lee J, Metcalf WW. Cyanohydrin phosphonate natural product from Streptomyces regensis. Journal of Natural Products. 77: 243-9. PMID 24437999 DOI: 10.1021/np400722m  1
2014 Benedict MN, Henriksen JR, Metcalf WW, Whitaker RJ, Price ND. ITEP: An integrated toolkit for exploration of microbial pan-genomes Bmc Genomics. 15. PMID 24387194 DOI: 10.1186/1471-2164-15-8  1
2014 Gao J, Ju KS, Yu X, Velásquez JE, Mukherjee S, Lee J, Zhao C, Evans BS, Doroghazi JR, Metcalf WW, van der Donk WA. Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster. Angewandte Chemie (International Ed. in English). 53: 1334-7. PMID 24376039 DOI: 10.1002/anie.201308363  1
2014 Ju KS, Doroghazi JR, Metcalf WW. Genomics-enabled discovery of phosphonate natural products and their biosynthetic pathways. Journal of Industrial Microbiology & Biotechnology. 41: 345-56. PMID 24271089 DOI: 10.1007/s10295-013-1375-2  0.72
2014 Albright JC, Goering AW, Doroghazi JR, Metcalf WW, Kelleher NL. Strain-specific proteogenomics accelerates the discovery of natural products via their biosynthetic pathways. Journal of Industrial Microbiology & Biotechnology. 41: 451-9. PMID 24242000 DOI: 10.1007/s10295-013-1373-4  1
2013 Yu X, Doroghazi JR, Janga SC, Zhang JK, Circello B, Griffin BM, Labeda DP, Metcalf WW. Diversity and abundance of phosphonate biosynthetic genes in nature. Proceedings of the National Academy of Sciences of the United States of America. 110: 20759-64. PMID 24297932 DOI: 10.1073/pnas.1315107110  1
2013 Doroghazi JR, Metcalf WW. Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes. Bmc Genomics. 14: 611. PMID 24020438 DOI: 10.1186/1471-2164-14-611  0.72
2013 Evans BS, Zhao C, Gao J, Evans CM, Ju KS, Doroghazi JR, van der Donk WA, Kelleher NL, Metcalf WW. Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection. Acs Chemical Biology. 8: 908-13. PMID 23474169 DOI: 10.1021/cb400102t  1
2013 Gonnerman MC, Benedict MN, Feist AM, Metcalf WW, Price ND. Genomically and biochemically accurate metabolic reconstruction of Methanosarcina barkeri Fusaro, iMG746. Biotechnology Journal. 8: 1070-9. PMID 23420771 DOI: 10.1002/biot.201200266  1
2012 Metcalf WW, Griffin BM, Cicchillo RM, Gao J, Janga SC, Cooke HA, Circello BT, Evans BS, Martens-Habbena W, Stahl DA, van der Donk WA. Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean. Science (New York, N.Y.). 337: 1104-7. PMID 22936780 DOI: 10.1126/science.1219875  1
2012 Kim SY, Ju KS, Metcalf WW, Evans BS, Kuzuyama T, Van Der Donk WA. Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species Antimicrobial Agents and Chemotherapy. 56: 4175-4183. PMID 22615277 DOI: 10.1128/AAC.06478-11  1
2012 Hung JE, Fogle EJ, Christman HD, Johannes TW, Zhao H, Metcalf WW, Van Der Donk WA. Investigation of the role of Arg301 identified in the X-ray structure of phosphite dehydrogenase Biochemistry. 51: 4254-4262. PMID 22564138 DOI: 10.1021/bi201691w  1
2012 Benedict MN, Gonnerman MC, Metcalf WW, Price ND. Genome-scale metabolic reconstruction and hypothesis testing in the methanogenic archaeon Methanosarcina acetivorans C2A. Journal of Bacteriology. 194: 855-65. PMID 22139506 DOI: 10.1128/JB.06040-11  1
2012 Chen Y, Ntai I, Ju KS, Unger M, Zamdborg L, Robinson SJ, Doroghazi JR, Labeda DP, Metcalf WW, Kelleher NL. A proteomic survey of nonribosomal peptide and polyketide biosynthesis in actinobacteria. Journal of Proteome Research. 11: 85-94. PMID 21978092 DOI: 10.1021/pr2009115  1
2011 Doroghazi JR, Ju KS, Brown DW, Labeda DP, Deng Z, Metcalf WW, Chen W, Price NP. Genome sequences of three tunicamycin-producing Streptomyces Strains, S. chartreusis NRRL 12338, S. chartreusis NRRL 3882, and S. lysosuperificus ATCC 31396. Journal of Bacteriology. 193: 7021-2. PMID 22123769 DOI: 10.1128/JB.06262-11  0.72
2011 Agarwal V, Borisova SA, Metcalf WW, van der Donk WA, Nair SK. Structural and mechanistic insights into C-P bond hydrolysis by phosphonoacetate hydrolase. Chemistry & Biology. 18: 1230-40. PMID 22035792 DOI: 10.1016/j.chembiol.2011.07.019  1
2011 Evans BS, Chen Y, Metcalf WW, Zhao H, Kelleher NL. Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo. Chemistry & Biology. 18: 601-7. PMID 21609841 DOI: 10.1016/j.chembiol.2011.03.008  1
2011 Borisova SA, Christman HD, Mourey Metcalf ME, Zulkepli NA, Zhang JK, Van Der Donk WA, Metcalf WW. Genetic and biochemical characterization of a pathway for the degradation of 2-aminoethylphosphonate in Sinorhizobium meliloti 1021 Journal of Biological Chemistry. 286: 22283-22290. PMID 21543322 DOI: 10.1074/jbc.M111.237735  1
2011 Circello BT, Miller CG, Lee JH, Van Der Donk WA, Metcalf WW. The antibiotic dehydrophos is converted to a toxic pyruvate analog by peptide bond cleavage in Salmonella enterica Antimicrobial Agents and Chemotherapy. 55: 3357-3362. PMID 21537024 DOI: 10.1128/AAC.01483-10  1
2010 Lee JH, Bae B, Kuemin M, Circello BT, Metcalf WW, Nair SK, Van Der Donk WA. Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis Proceedings of the National Academy of Sciences of the United States of America. 107: 17557-17562. PMID 20876132 DOI: 10.1073/pnas.1006848107  1
2010 Simeonova DD, Wilson MM, Metcalf WW, Schink B. Identification and heterologous expression of genes involved in anaerobic dissimilatory phosphite oxidation by Desulfotignum phosphitoxidans. Journal of Bacteriology. 192: 5237-44. PMID 20622064 DOI: 10.1128/JB.00541-10  1
2010 Circello BT, Eliot AC, Lee JH, van der Donk WA, Metcalf WW. Molecular Cloning and Heterologous Expression of the Dehydrophos Biosynthetic Gene Cluster Chemistry and Biology. 17: 402-411. PMID 20416511 DOI: 10.1016/j.chembiol.2010.03.007  1
2010 Johannes TW, DeSieno MA, Griffin BM, Thomas PM, Kelleher NL, Metcalf WW, Zhao H. Deciphering the late biosynthetic steps of antimalarial compound FR-900098. Chemistry & Biology. 17: 57-64. PMID 20142041 DOI: 10.1016/j.chembiol.2009.12.009  1
2010 Borisova SA, Circello BT, Zhang JK, van der Donk WA, Metcalf WW. Biosynthesis of Rhizocticins, Antifungal Phosphonate Oligopeptides Produced by Bacillus subtilis ATCC6633 Chemistry and Biology. 17: 28-37. PMID 20142038 DOI: 10.1016/j.chembiol.2009.11.017  1
2010 Wolfe RS, Metcalf WW. A vacuum-vortex technique for preparation of anoxic solutions or liquid culture media in small volumes for cultivating methanogens or other strict anaerobes. Anaerobe. 16: 216-9. PMID 20004732 DOI: 10.1016/j.anaerobe.2009.11.005  0.92
2010 Buan NR, Metcalf WW. Methanogenesis by Methanosarcina acetivorans involves two structurally and functionally distinct classes of heterodisulfide reductase. Molecular Microbiology. 75: 843-53. PMID 19968794 DOI: 10.1111/j.1365-2958.2009.06990.x  1
2009 Kulkarni G, Kridelbaugh DM, Guss AM, Metcalf WW. Hydrogen is a preferred intermediate in the energy-conserving electron transport chain of Methanosarcina barkeri. Proceedings of the National Academy of Sciences of the United States of America. 106: 15915-20. PMID 19805232 DOI: 10.1073/pnas.0905914106  1
2009 Opulencia RB, Bose A, Metcalf WW. Physiology and posttranscriptional regulation of methanol:coenzyme M methyltransferase isozymes in Methanosarcina acetivorans C2A. Journal of Bacteriology. 191: 6928-35. PMID 19767431 DOI: 10.1128/JB.00947-09  1
2009 Bose A, Kulkarni G, Metcalf WW. Regulation of putative methyl-sulphide methyltransferases in Methanosarcina acetivorans C2A. Molecular Microbiology. 74: 227-38. PMID 19732345 DOI: 10.1111/j.1365-2958.2009.06864.x  1
2009 Ferguson JT, Wenger CD, Metcalf WW, Kelleher NL. Top-down proteomics reveals novel protein forms expressed in Methanosarcina acetivorans. Journal of the American Society For Mass Spectrometry. 20: 1743-50. PMID 19577935 DOI: 10.1016/j.jasms.2009.05.014  1
2009 Cicchillo RM, Zhang H, Blodgett JAV, Whitteck JT, Li G, Nair SK, Van Der Donk WA, Metcalf WW. An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis Nature. 459: 871-874. PMID 19516340 DOI: 10.1038/nature07972  1
2009 Metcalf WW, Van Der Donk WA. Biosynthesis of phosphonic and phosphinic acid natural products Annual Review of Biochemistry. 78: 65-94. PMID 19489722 DOI: 10.1146/annurev.biochem.78.091707.100215  1
2009 Yang K, Wang M, Metcalf WW. Uptake of glycerol-2-phosphate via the ugp-encoded transporter in Escherichia coli K-12. Journal of Bacteriology. 191: 4667-70. PMID 19429609 DOI: 10.1128/JB.00235-09  1
2009 Guss AM, Kulkarni G, Metcalf WW. Differences in hydrogenase gene expression between Methanosarcina acetivorans and Methanosarcina barkeri. Journal of Bacteriology. 191: 2826-33. PMID 19201801 DOI: 10.1128/JB.00563-08  1
2008 Guss AM, Rother M, Zhang JK, Kulkarni G, Metcalf WW. New methods for tightly regulated gene expression and highly efficient chromosomal integration of cloned genes for Methanosarcina species. Archaea (Vancouver, B.C.). 2: 193-203. PMID 19054746  1
2008 Eliot AC, Griffin BM, Thomas PM, Johannes TW, Kelleher NL, Zhao H, Metcalf WW. Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098. Chemistry & Biology. 15: 765-70. PMID 18721747 DOI: 10.1016/j.chembiol.2008.07.010  1
2008 Shao Z, Blodgett JA, Circello BT, Eliot AC, Woodyer R, Li G, van der Donk WA, Metcalf WW, Zhao H. Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways. The Journal of Biological Chemistry. 283: 23161-8. PMID 18544530 DOI: 10.1074/jbc.M801788200  1
2008 Bose A, Pritchett MA, Metcalf WW. Genetic analysis of the methanol- and methylamine-specific methyltransferase 2 genes of Methanosarcina acetivorans C2A. Journal of Bacteriology. 190: 4017-26. PMID 18375552 DOI: 10.1128/JB.00117-08  1
2008 Welander PV, Metcalf WW. Mutagenesis of the C1 oxidation pathway in Methanosarcina barkeri: new insights into the Mtr/Mer bypass pathway. Journal of Bacteriology. 190: 1928-36. PMID 18178739 DOI: 10.1128/JB.01424-07  1
2008 Bose A, Metcalf WW. Distinct regulators control the expression of methanol methyltransferase isozymes in Methanosarcina acetivorans C2A. Molecular Microbiology. 67: 649-61. PMID 18086201 DOI: 10.1111/j.1365-2958.2007.06075.x  1
2007 White AK, Metcalf WW. Microbial metabolism of reduced phosphorus compounds. Annual Review of Microbiology. 61: 379-400. PMID 18035609 DOI: 10.1146/annurev.micro.61.080706.093357  0.44
2007 Whitteck JT, Ni W, Griffin BM, Eliot AC, Thomas PM, Kelleher NL, Metcalf WW, van der Donk WA. Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid. Angewandte Chemie (International Ed. in English). 46: 9089-92. PMID 17990255 DOI: 10.1002/anie.200703810  1
2007 Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW. Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nature Chemical Biology. 3: 480-5. PMID 17632514 DOI: 10.1038/nchembio.2007.9  1
2007 Mahapatra A, Srinivasan G, Richter KB, Meyer A, Lienard T, Zhang JK, Zhao G, Kang PT, Chan M, Gottschalk G, Metcalf WW, Krzycki JA. Class I and class II lysyl-tRNA synthetase mutants and the genetic encoding of pyrrolysine in Methanosarcina spp. Molecular Microbiology. 64: 1306-18. PMID 17542922 DOI: 10.1111/j.1365-2958.2007.05740.x  1
2006 Woodyer RD, Shao Z, Thomas PM, Kelleher NL, Blodgett JA, Metcalf WW, van der Donk WA, Zhao H. Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chemistry & Biology. 13: 1171-82. PMID 17113999 DOI: 10.1016/j.chembiol.2006.09.007  1
2006 Bose A, Pritchett MA, Rother M, Metcalf WW. Differential regulation of the three methanol methyltransferase isozymes in Methanosarcina acetivorans C2A. Journal of Bacteriology. 188: 7274-83. PMID 17015666 DOI: 10.1128/JB.00535-06  1
2006 Maeder DL, Anderson I, Brettin TS, Bruce DC, Gilna P, Han CS, Lapidus A, Metcalf WW, Saunders E, Tapia R, Sowers KR. The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes. Journal of Bacteriology. 188: 7922-31. PMID 16980466 DOI: 10.1128/JB.00810-06  1
2006 Mahapatra A, Patel A, Soares JA, Larue RC, Zhang JK, Metcalf WW, Krzycki JA. Characterization of a Methanosarcina acetivorans mutant unable to translate UAG as pyrrolysine. Molecular Microbiology. 59: 56-66. PMID 16359318 DOI: 10.1111/j.1365-2958.2005.04927.x  1
2006 Patrie SM, Ferguson JT, Robinson DE, Whipple D, Rother M, Metcalf WW, Kelleher NL. Top down mass spectrometry of < 60-kDa proteins from Methanosarcina acetivorans using quadrupole FRMS with automated octopole collisionally activated dissociation. Molecular & Cellular Proteomics : McP. 5: 14-25. PMID 16236702 DOI: 10.1074/mcp.M500219-MCP200  1
2005 Rother M, Metcalf WW. Genetic technologies for Archaea. Current Opinion in Microbiology. 8: 745-51. PMID 16257573 DOI: 10.1016/j.mib.2005.10.010  0.52
2005 Forzi L, Koch J, Guss AM, Radosevich CG, Metcalf WW, Hedderich R. Assignment of the [4Fe-4S] clusters of Ech hydrogenase from Methanosarcina barkeri to individual subunits via the characterization of site-directed mutants. The Febs Journal. 272: 4741-53. PMID 16156794 DOI: 10.1111/j.1742-4658.2005.04889.x  0.96
2005 Rother M, Boccazzi P, Bose A, Pritchett MA, Metcalf WW. Methanol-dependent gene expression demonstrates that methyl-coenzyme M reductase is essential in Methanosarcina acetivorans C2A and allows isolation of mutants with defects in regulation of the methanol utilization pathway. Journal of Bacteriology. 187: 5552-9. PMID 16077099 DOI: 10.1128/JB.187.16.5552-5559.2005  1
2005 Welander PV, Metcalf WW. Loss of the mtr operon in Methanosarcina blocks growth on methanol, but not methanogenesis, and reveals an unknown methanogenic pathway. Proceedings of the National Academy of Sciences of the United States of America. 102: 10664-9. PMID 16024727 DOI: 10.1073/pnas.0502623102  1
2005 Pritchett MA, Metcalf WW. Genetic, physiological and biochemical characterization of multiple methanol methyltransferase isozymes in Methanosarcina acetivorans C2A. Molecular Microbiology. 56: 1183-94. PMID 15882413 DOI: 10.1111/j.1365-2958.2005.04616.x  1
2005 Ehlers C, Weidenbach K, Veit K, Deppenmeier U, Metcalf WW, Schmitz RA. Development of genetic methods and construction of a chromosomal glnK1 mutant in Methanosarcina mazei strain Gö1. Molecular Genetics and Genomics : Mgg. 273: 290-8. PMID 15824904 DOI: 10.1007/s00438-005-1128-7  1
2005 Guss AM, Mukhopadhyay B, Zhang JK, Metcalf WW. Genetic analysis of mch mutants in two Methanosarcina species demonstrates multiple roles for the methanopterin-dependent C-1 oxidation/reduction pathway and differences in H(2) metabolism between closely related species. Molecular Microbiology. 55: 1671-80. PMID 15752192 DOI: 10.1111/j.1365-2958.2005.04514.x  0.96
2005 Wilson MM, Metcalf WW. Genetic diversity and horizontal transfer of genes involved in oxidation of reduced phosphorus compounds by Alcaligenes faecalis WM2072. Applied and Environmental Microbiology. 71: 290-6. PMID 15640200 DOI: 10.1128/AEM.71.1.290-296.2005  1
2005 Blodgett JA, Zhang JK, Metcalf WW. Molecular cloning, sequence analysis, and heterologous expression of the phosphinothricin tripeptide biosynthetic gene cluster from Streptomyces viridochromogenes DSM 40736. Antimicrobial Agents and Chemotherapy. 49: 230-40. PMID 15616300 DOI: 10.1128/AAC.49.1.230-240.2005  0.64
2004 Rother M, Metcalf WW. Anaerobic growth of Methanosarcina acetivorans C2A on carbon monoxide: an unusual way of life for a methanogenic archaeon. Proceedings of the National Academy of Sciences of the United States of America. 101: 16929-34. PMID 15550538 DOI: 10.1073/pnas.0407486101  0.52
2004 White AK, Metcalf WW. The htx and ptx operons of Pseudomonas stutzeri WM88 are new members of the pho regulon. Journal of Bacteriology. 186: 5876-82. PMID 15317793 DOI: 10.1128/JB.186.17.5876-5882.2004  0.44
2004 White AK, Metcalf WW. Two C-P lyase operons in Pseudomonas stutzeri and their roles in the oxidation of phosphonates, phosphite, and hypophosphite. Journal of Bacteriology. 186: 4730-9. PMID 15231805 DOI: 10.1128/JB.186.14.4730-4739.2004  0.44
2004 Yang K, Metcalf WW. A new activity for an old enzyme: Escherichia coli bacterial alkaline phosphatase is a phosphite-dependent hydrogenase. Proceedings of the National Academy of Sciences of the United States of America. 101: 7919-24. PMID 15148399 DOI: 10.1073/pnas.0400664101  1
2004 Pritchett MA, Zhang JK, Metcalf WW. Development of a markerless genetic exchange method for Methanosarcina acetivorans C2A and its use in construction of new genetic tools for methanogenic archaea. Applied and Environmental Microbiology. 70: 1425-33. PMID 15006762 DOI: 10.1128/AEM.70.3.1425-1433.2004  1
2002 Vrtis JM, White AK, Metcalf WW, van der Donk WA. Phosphite dehydrogenase: a versatile cofactor-regeneration enzyme. Angewandte Chemie (International Ed. in English). 41: 3257-9. PMID 12207407 DOI: 10.1002/1521-3773(20020902)41:17<3257::AID-ANIE3257>3.0.CO;2-N  1
2002 Larsen RA, Wilson MM, Guss AM, Metcalf WW. Genetic analysis of pigment biosynthesis in Xanthobacter autotrophicus Py2 using a new, highly efficient transposon mutagenesis system that is functional in a wide variety of bacteria. Archives of Microbiology. 178: 193-201. PMID 12189420 DOI: 10.1007/s00203-002-0442-2  1
2002 White AK, Metcalf WW. Isolation and biochemical characterization of hypophosphite/2-oxoglutarate dioxygenase. A novel phosphorus-oxidizing enzyme from Psuedomonas stutzeri WM88. The Journal of Biological Chemistry. 277: 38262-71. PMID 12161433 DOI: 10.1074/jbc.M204605200  0.44
2002 Kim AD, Baker AS, Dunaway-Mariano D, Metcalf WW, Wanner BL, Martin BM. The 2-aminoethylphosphonate-specific transaminase of the 2-aminoethylphosphonate degradation pathway. Journal of Bacteriology. 184: 4134-40. PMID 12107130 DOI: 10.1128/JB.184.15.4134-4140.2002  1
2002 Sluis MK, Larsen RA, Krum JG, Anderson R, Metcalf WW, Ensign SA. Biochemical, molecular, and genetic analyses of the acetone carboxylases from Xanthobacter autotrophicus strain Py2 and Rhodobacter capsulatus strain B10. Journal of Bacteriology. 184: 2969-77. PMID 12003937 DOI: 10.1128/JB.184.11.2969-2977.2002  1
2002 Galagan JE, Nusbaum C, Roy A, Endrizzi MG, Macdonald P, FitzHugh W, Calvo S, Engels R, Smirnov S, Atnoor D, Brown A, Allen N, Naylor J, Stange-Thomann N, DeArellano K, ... ... Metcalf WW, et al. The genome of M. acetivorans reveals extensive metabolic and physiological diversity. Genome Research. 12: 532-42. PMID 11932238 DOI: 10.1101/gr.223902  1
2002 Meuer J, Kuettner HC, Zhang JK, Hedderich R, Metcalf WW. Genetic analysis of the archaeon Methanosarcina barkeri Fusaro reveals a central role for Ech hydrogenase and ferredoxin in methanogenesis and carbon fixation. Proceedings of the National Academy of Sciences of the United States of America. 99: 5632-7. PMID 11929975 DOI: 10.1073/pnas.072615499  0.64
2002 Zhang JK, White AK, Kuettner HC, Boccazzi P, Metcalf WW. Directed mutagenesis and plasmid-based complementation in the methanogenic archaeon Methanosarcina acetivorans C2A demonstrated by genetic analysis of proline biosynthesis. Journal of Bacteriology. 184: 1449-54. PMID 11844777  0.64
2000 Zhang JK, Pritchett MA, Lampe DJ, Robertson HM, Metcalf WW. In vivo transposon mutagenesis of the methanogenic archaeon Methanosarcina acetivorans C2A using a modified version of the insect mariner-family transposable element Himar1. Proceedings of the National Academy of Sciences of the United States of America. 97: 9665-70. PMID 10920201 DOI: 10.1073/pnas.160272597  1
1998 Metcalf WW, Wolfe RS. Molecular genetic analysis of phosphite and hypophosphite oxidation by Pseudomonas stutzeri WM88. Journal of Bacteriology. 180: 5547-58. PMID 9791102  0.92
1998 Baker AS, Ciocci MJ, Metcalf WW, Kim J, Babbitt PC, Wanner BL, Martin BM, Dunaway-Mariano D. Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis. Biochemistry. 37: 9305-15. PMID 9649311 DOI: 10.1021/bi972677d  1
1998 Metcalf WW, Zhang JK, Wolfe RS. An anaerobic, intrachamber incubator for growth of Methanosarcina spp. on methanol-containing solid media. Applied and Environmental Microbiology. 64: 768-70. PMID 9464421  0.92
1997 Metcalf WW, Jun Kai Zhang, Apolinario E, Sowers KR, Wolfe RS. A genetic system for Archaea of the genus Methanosarcina: Liposome- mediated transformation and construction of shuttle vectors Proceedings of the National Academy of Sciences of the United States of America. 94: 2626-2631. PMID 9122246 DOI: 10.1073/pnas.94.6.2626  1
1996 Metcalf WW, Zhang JK, Shi X, Wolfe RS. Molecular, genetic, and biochemical characterization of the serC gene of Methanosarcina barkeri Fusaro. Journal of Bacteriology. 178: 5797-802. PMID 8824630  0.92
1996 Metcalf WW, Jiang W, Daniels LL, Kim SK, Haldimann A, Wanner BL. Conditionally replicative and conjugative plasmids carrying lacZ alpha for cloning, mutagenesis, and allele replacement in bacteria. Plasmid. 35: 1-13. PMID 8693022 DOI: 10.1006/plas.1996.0001  0.92
1995 Jiang W, Metcalf WW, Lee KS, Wanner BL. Molecular cloning, mapping, and regulation of Pho regulon genes for phosphonate breakdown by the phosphonatase pathway of Salmonella typhimurium LT2. Journal of Bacteriology. 177: 6411-21. PMID 7592415  0.92
1994 Metcalf WW, Jiang W, Wanner BL. Use of the rep technique for allele replacement to construct new Escherichia coli hosts for maintenance of R6K gamma origin plasmids at different copy numbers. Gene. 138: 1-7. PMID 8125283  0.92
1993 Metcalf WW, Wanner BL. Mutational analysis of an Escherichia coli fourteen-gene operon for phosphonate degradation, using TnphoA' elements. Journal of Bacteriology. 175: 3430-42. PMID 8388873  0.92
1993 Metcalf WW, Wanner BL. Evidence for a fourteen-gene, phnC to phnP locus for phosphonate metabolism in Escherichia coli. Gene. 129: 27-32. PMID 8335257  0.92
1993 Metcalf WW, Wanner BL. Construction of new beta-glucuronidase cassettes for making transcriptional fusions and their use with new methods for allele replacement. Gene. 129: 17-25. PMID 8335256  0.92
1992 Lee KS, Metcalf WW, Wanner BL. Evidence for two phosphonate degradative pathways in Enterobacter aerogenes. Journal of Bacteriology. 174: 2501-10. PMID 1556070  0.92
1992 Wanner BL, Metcalf WW. Molecular genetic studies of a 10.9-kb operon in Escherichia coli for phosphonate uptake and biodegradation. Fems Microbiology Letters. 100: 133-9. PMID 1335942  0.92
1991 Metcalf WW, Wanner BL. Involvement of the Escherichia coli phn (psiD) gene cluster in assimilation of phosphorus in the form of phosphonates, phosphite, Pi esters, and Pi. Journal of Bacteriology. 173: 587-600. PMID 1846145  0.92
1990 Metcalf WW, Steed PM, Wanner BL. Identification of phosphate starvation-inducible genes in Escherichia coli K-12 by DNA sequence analysis of psi::lacZ(Mu d1) transcriptional fusions. Journal of Bacteriology. 172: 3191-200. PMID 2160940  0.92
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