Shiou-Chuan Tsai - Publications

Biological Sciences - Ph.D. University of California, Irvine, Irvine, CA 
Biochemistry, Molecular Biology, Microbiology Biology

49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Milligan JC, Lee DJ, Jackson DR, Schaub AJ, Beld J, Barajas JF, Hale JJ, Luo R, Burkart MD, Tsai SC. Molecular basis for interactions between an acyl carrier protein and a ketosynthase. Nature Chemical Biology. PMID 31209348 DOI: 10.1038/s41589-019-0301-y  0.48
2019 Schaub AJ, Moreno GO, Zhao S, Truong HV, Luo R, Tsai SC. Computational structural enzymology methodologies for the study and engineering of fatty acid synthases, polyketide synthases and nonribosomal peptide synthetases. Methods in Enzymology. 622: 375-409. PMID 31155062 DOI: 10.1016/bs.mie.2019.03.001  0.4
2018 Ellis BD, Milligan JC, White AR, Duong V, Altman PX, Mohammed L, Crump MP, Crosby J, Luo R, Vanderwal CD, Tsai SC. An Oxetane-based Polyketide Surrogate to Probe Substrate Binding in a Polyketide Synthase. Journal of the American Chemical Society. PMID 29620883 DOI: 10.1021/jacs.7b11793  0.48
2017 Jackson DR, Shakya G, Patel AB, Mohammed LY, Vasilakis K, Wattana-Amorn P, Valentic TR, Milligan J, Crump MP, Crosby J, Tsai SC. Structural and Functional Studies of the Daunorubicin Priming Ketosynthase DpsC. Acs Chemical Biology. PMID 29161022 DOI: 10.1021/acschembio.7b00551  0.64
2017 Barajas JF, Shakya G, Moreno G, Rivera H, Jackson DR, Topper CL, Vagstad AL, La Clair JJ, Townsend CA, Burkart MD, Tsai SC. Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases. Proceedings of the National Academy of Sciences of the United States of America. PMID 28484029 DOI: 10.1073/pnas.1609001114  0.64
2016 Valentic TR, Jackson DR, Brady SF, Tsai SS. Comprehensive Analysis of a Novel Ketoreductase for Pentangular Polyphenol Biosynthesis. Acs Chemical Biology. PMID 27779377 DOI: 10.1021/acschembio.6b00658  0.4
2016 Barajas JF, Finzel K, Valentic TR, Shakya G, Gamarra N, Martinez D, Meier JL, Vagstad AL, Newman AG, Townsend CA, Burkart MD, Tsai SC. Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain. Angewandte Chemie (International Ed. in English). PMID 27653519 DOI: 10.1002/anie.201605401  0.64
2016 Rivera H, Dhar S, La Clair JJ, Tsai SC, Burkart MD. An unusual intramolecular trans-amidation. Tetrahedron. 72: 3605-3608. PMID 27346894 DOI: 10.1016/j.tet.2016.01.062  0.48
2016 White AR, Duggan BM, Tsai SC, Vanderwal CD. The Alga Ochromonas danica Produces Bromosulfolipids. Organic Letters. PMID 26889956 DOI: 10.1021/acs.orglett.6b00230  0.48
2016 Jackson D, Yu X, Wang G, Patel A, Barajas J, Sasaki E, Metsa-Ketala M, Liu HW, Rohr J, Tsai SS. Insights Into Complex Oxidation During BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE. Acs Chemical Biology. PMID 26813028 DOI: 10.1021/acschembio.5b00913  0.48
2015 Caldara-Festin G, Jackson DR, Barajas JF, Valentic TR, Patel AB, Aguilar S, Nguyen M, Vo M, Khanna A, Sasaki E, Liu HW, Tsai SC. Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases. Proceedings of the National Academy of Sciences of the United States of America. PMID 26631750 DOI: 10.1073/pnas.1512976112  0.48
2015 Finzel K, Nguyen C, Jackson DR, Gupta A, Tsai SC, Burkart MD. Probing the Substrate Specificity and Protein-Protein Interactions of the E. coli Fatty Acid Dehydratase, FabA. Chemistry & Biology. PMID 26526101 DOI: 10.1016/j.chembiol.2015.09.009  0.48
2015 Jackson DR, Tu SS, Nguyen M, Barajas JF, Schaub AJ, Krug D, Pistorius D, Luo R, Müller R, Tsai SC. Structural Insights into Anthranilate Priming during Type II Polyketide Biosynthesis. Acs Chemical Biology. PMID 26473393 DOI: 10.1021/acschembio.5b00500  0.48
2015 Barajas JF, Phelan RM, Schaub AJ, Kliewer JT, Kelly PJ, Jackson DR, Luo R, Keasling JD, Tsai SC. Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols. Chemistry & Biology. PMID 26235055 DOI: 10.1016/j.chembiol.2015.06.022  0.4
2014 Shakya G, Rivera H, Lee DJ, Jaremko MJ, La Clair JJ, Fox DT, Haushalter RW, Schaub AJ, Bruegger J, Barajas JF, White AR, Kaur P, Gwozdziowski ER, Wong F, Tsai SC, et al. Modeling linear and cyclic PKS intermediates through atom replacement. Journal of the American Chemical Society. 136: 16792-9. PMID 25406716 DOI: 10.1021/ja5064857  0.48
2014 Nguyen C, Haushalter RW, Lee DJ, Markwick PR, Bruegger J, Caldara-Festin G, Finzel K, Jackson DR, Ishikawa F, O'Dowd B, McCammon JA, Opella SJ, Tsai SC, Burkart MD. Trapping the dynamic acyl carrier protein in fatty acid biosynthesis. Nature. 505: 427-31. PMID 24362570 DOI: 10.1038/nature12810  0.48
2013 Javidpour P, Bruegger J, Srithahan S, Korman TP, Crump MP, Crosby J, Burkart MD, Tsai SC. The determinants of activity and specificity in actinorhodin type II polyketide ketoreductase. Chemistry & Biology. 20: 1225-34. PMID 24035284 DOI: 10.1016/j.chembiol.2013.07.016  0.48
2013 Bruegger J, Haushalter RW, Haushalter B, Vagstad AL, Vagstad A, Shakya G, Mih N, Townsend CA, Burkart MD, Tsai SC. Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers. Chemistry & Biology. 20: 1135-46. PMID 23993461 DOI: 10.1016/j.chembiol.2013.07.012  0.48
2012 Ames BD, Nguyen C, Bruegger J, Smith P, Xu W, Ma S, Wong E, Wong S, Xie X, Li JW, Vederas JC, Tang Y, Tsai SC. Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 11144-9. PMID 22733743 DOI: 10.1073/pnas.1113029109  0.48
2012 Lee MY, Ames BD, Tsai SC. Insight into the molecular basis of aromatic polyketide cyclization: crystal structure and in vitro characterization of WhiE-ORFVI. Biochemistry. 51: 3079-91. PMID 22432862 DOI: 10.1021/bi201705q  1
2011 Ames BD, Lee MY, Moody C, Zhang W, Tang Y, Tsai SC. Structural and biochemical characterization of ZhuI aromatase/cyclase from the R1128 polyketide pathway. Biochemistry. 50: 8392-406. PMID 21870821 DOI: 10.1021/bi200593m  1
2011 Javidpour P, Das A, Khosla C, Tsai SC. Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (HedKR): molecular basis of stereo- and regiospecificities. Biochemistry. 50: 7426-39. PMID 21776967 DOI: 10.1021/bi2006866  0.48
2011 Javidpour P, Korman TP, Shakya G, Tsai SC. Structural and biochemical analyses of regio- and stereospecificities observed in a type II polyketide ketoreductase. Biochemistry. 50: 4638-49. PMID 21506596 DOI: 10.1021/bi200335f  0.64
2011 Gago G, Diacovich L, Arabolaza A, Tsai SC, Gramajo H. Fatty acid biosynthesis in actinomycetes. Fems Microbiology Reviews. 35: 475-97. PMID 21204864 DOI: 10.1111/j.1574-6976.2010.00259.x  0.32
2010 Arabolaza A, Shillito ME, Lin TW, Diacovich L, Melgar M, Pham H, Amick D, Gramajo H, Tsai SC. Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor. Biochemistry. 49: 7367-76. PMID 20690600 DOI: 10.1021/bi1005305  0.32
2010 Khakshoor O, Lin AJ, Korman TP, Sawaya MR, Tsai SC, Eisenberg D, Nowick JS. X-ray crystallographic structure of an artificial beta-sheet dimer. Journal of the American Chemical Society. 132: 11622-8. PMID 20669960 DOI: 10.1021/ja103438w  0.48
2010 Korman TP, Crawford JM, Labonte JW, Newman AG, Wong J, Townsend CA, Tsai SC. Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 6246-51. PMID 20332208 DOI: 10.1073/pnas.0913531107  0.48
2009 Crawford JM, Korman TP, Labonte JW, Vagstad AL, Hill EA, Kamari-Bidkorpeh O, Tsai SC, Townsend CA. Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. Nature. 461: 1139-43. PMID 19847268 DOI: 10.1038/nature08475  0.48
2009 Smith P, Zhou B, Ho N, Yuan YC, Su L, Tsai SC, Yen Y. 2.6 A X-ray crystal structure of human p53R2, a p53-inducible ribonucleotide reductase . Biochemistry. 48: 11134-41. PMID 19728742 DOI: 10.1021/bi9001425  0.32
2009 Kurth DG, Gago GM, de la Iglesia A, Bazet Lyonnet B, Lin TW, Morbidoni HR, Tsai SC, Gramajo H. ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria. Microbiology (Reading, England). 155: 2664-75. PMID 19423629 DOI: 10.1099/mic.0.027714-0  0.32
2009 Swamidass SJ, Azencott CA, Lin TW, Gramajo H, Tsai SC, Baldi P. Influence relevance voting: an accurate and interpretable virtual high throughput screening method. Journal of Chemical Information and Modeling. 49: 756-66. PMID 19391629 DOI: 10.1021/ci8004379  0.48
2009 Tsai SC, Ames BD. Structural enzymology of polyketide synthases. Methods in Enzymology. 459: 17-47. PMID 19362634 DOI: 10.1016/S0076-6879(09)04602-3  1
2008 Smith P, Szu PH, Bui C, Liu HW, Tsai SC. Structure and mutagenic conversion of E1 dehydrase: at the crossroads of dehydration, amino transfer, and epimerization. Biochemistry. 47: 6329-41. PMID 18491919 DOI: 10.1021/bi702449p  0.32
2008 Ames BD, Korman TP, Zhang W, Smith P, Vu T, Tang Y, Tsai SC. Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proceedings of the National Academy of Sciences of the United States of America. 105: 5349-54. PMID 18388203 DOI: 10.1073/pnas.0709223105  1
2008 Korman TP, Tan YH, Wong J, Luo R, Tsai SC. Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase. Biochemistry. 47: 1837-47. PMID 18205400 DOI: 10.1021/bi7016427  0.64
2006 Zhang W, Ames BD, Tsai SC, Tang Y. Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase. Applied and Environmental Microbiology. 72: 2573-80. PMID 16597959 DOI: 10.1128/AEM.72.4.2573-2580.2006  1
2006 Smith P, Lin A, Szu PH, Liu HW, Tsai SC. Biosynthesis of a 3,6-dideoxyhexose: crystallization and X-ray diffraction of CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase (E1) for ascarylose biosynthesis. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 231-4. PMID 16511309 DOI: 10.1107/S1744309106003721  0.32
2006 Lin TW, Melgar MM, Kurth D, Swamidass SJ, Purdon J, Tseng T, Gago G, Baldi P, Gramajo H, Tsai SC. Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 103: 3072-7. PMID 16492739 DOI: 10.1073/pnas.0510580103  0.48
2006 Gago G, Kurth D, Diacovich L, Tsai SC, Gramajo H. Biochemical and structural characterization of an essential acyl coenzyme A carboxylase from Mycobacterium tuberculosis. Journal of Bacteriology. 188: 477-86. PMID 16385038 DOI: 10.1128/JB.188.2.477-486.2006  0.32
2004 Korman TP, Hill JA, Vu TN, Tsai SC. Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity. Biochemistry. 43: 14529-38. PMID 15544323 DOI: 10.1021/bi048133a  0.64
2004 Diacovich L, Mitchell DL, Pham H, Gago G, Melgar MM, Khosla C, Gramajo H, Tsai SC. Crystal structure of the β-subunit of acyl-CoA carboxylase: Structure-based engineering of substrate specificity Biochemistry. 43: 14027-14036. PMID 15518551 DOI: 10.1021/bi049065v  0.48
2004 Tsai SC. A fine balancing act of type III polyketide synthase. Chemistry & Biology. 11: 1177-8. PMID 15380178 DOI: 10.1016/j.chembiol.2004.09.001  0.48
2003 Watanabe K, Khosla C, Stroud RM, Tsai SC. Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis. Journal of Molecular Biology. 334: 435-44. PMID 14623185 DOI: 10.1016/j.jmb.2003.10.021  0.48
2003 Tang Y, Tsai SC, Khosla C. Polyketide chain length control by chain length factor. Journal of the American Chemical Society. 125: 12708-9. PMID 14558809 DOI: 10.1021/ja0378759  0.48
2003 Tsai SC, Klinman JP. De novo design and utilization of photolabile caged substrates as probes of hydrogen tunneling with horse liver alcohol dehydrogenase at sub-zero temperatures: a cautionary note. Bioorganic Chemistry. 31: 172-90. PMID 12729574 DOI: 10.1016/S0045-2068(03)00018-X  0.48
2003 Keatinge-Clay AT, Shelat AA, Savage DF, Tsai SC, Miercke LJ, O'Connell JD, Khosla C, Stroud RM. Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. Structure (London, England : 1993). 11: 147-54. PMID 12575934 DOI: 10.1016/S0969-2126(03)00004-2  0.48
2002 Pan H, Tsai Sc, Meadows ES, Miercke LJ, Keatinge-Clay AT, O'Connell J, Khosla C, Stroud RM. Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. Structure (London, England : 1993). 10: 1559-68. PMID 12429097 DOI: 10.1016/S0969-2126(02)00889-4  0.48
2002 Tsai SC, Lu H, Cane DE, Khosla C, Stroud RM. Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. Biochemistry. 41: 12598-606. PMID 12379102 DOI: 10.1021/bi0260177  0.48
2002 Lu H, Tsai SC, Khosla C, Cane DE. Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase. Biochemistry. 41: 12590-7. PMID 12379101 DOI: 10.1021/bi026006d  0.48
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