Patricia Gearhart - Publications

Molecular Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, United States 

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Hutchinson MA, Park HS, Zanotti KJ, Alvarez-Gonzalez J, Zhang J, Zhang L, Telljohann R, Wang M, Lakatta EG, Gearhart PJ, Maul RW. Auto-Antibody Production During Experimental Atherosclerosis in Mice. Frontiers in Immunology. 12: 695220. PMID 34305930 DOI: 10.3389/fimmu.2021.695220  0.44
2021 Alvarez-Gonzalez J, Yasgar A, Maul RW, Rieffer AE, Crawford DJ, Salamango DJ, Dorjsuren D, Zakharov AV, Jansen DJ, Rai G, Marugan J, Simeonov A, Harris RS, Kohli RM, Gearhart PJ. Small Molecule Inhibitors of Activation-Induced Deaminase Decrease Class Switch Recombination in B Cells. Acs Pharmacology & Translational Science. 4: 1214-1226. PMID 34151211 DOI: 10.1021/acsptsci.1c00064  0.44
2021 Maul RW, Catalina MD, Kumar V, Bachali P, Grammer AC, Wang S, Yang W, Hasni S, Ettinger R, Lipsky PE, Gearhart PJ. Transcriptome and IgH Repertoire Analyses Show That CD11c B Cells Are a Distinct Population With Similarity to B Cells Arising in Autoimmunity and Infection. Frontiers in Immunology. 12: 649458. PMID 33815408 DOI: 10.3389/fimmu.2021.649458  0.44
2020 Jones BG, Sealy RE, Penkert RR, Surman SL, Birshtein BK, Xu B, Neale G, Maul RW, Gearhart PJ, Hurwitz JL. From Influenza Virus Infections to Lupus: Synchronous Estrogen Receptor and RNA Polymerase II Binding Within the Immunoglobulin Heavy Chain Locus. Viral Immunology. PMID 32105583 DOI: 10.1089/Vim.2019.0144  0.44
2019 Jones BG, Penkert RR, Surman SL, Sealy RE, Pelletier S, Xu B, Neale G, Maul RW, Gearhart PJ, Hurwitz JL. Matters of life and death: How estrogen and estrogen receptor binding to the immunoglobulin heavy chain locus may influence outcomes of infection, allergy, and autoimmune disease. Cellular Immunology. 346: 103996. PMID 31703914 DOI: 10.1016/J.Cellimm.2019.103996  0.44
2019 Russell Knode LM, Park HS, Maul RW, Gearhart PJ. B cells from young and old mice switch isotypes with equal frequencies after ex vivo stimulation. Cellular Immunology. 103966. PMID 31447053 DOI: 10.1016/J.Cellimm.2019.103966  0.52
2019 Zanotti KJ, Maul RW, Yang W, Gearhart PJ. DNA Breaks in Ig V Regions Are Predominantly Single Stranded and Are Generated by UNG and MSH6 DNA Repair Pathways. Journal of Immunology (Baltimore, Md. : 1950). PMID 30665938 DOI: 10.4049/Jimmunol.1801183  0.44
2018 Jones BG, Sealy RE, Penkert RR, Surman SL, Maul RW, Neale G, Xu B, Gearhart PJ, Hurwitz JL. Complex sex-biased antibody responses: Estrogen receptors bind estrogen response elements centered within immunoglobulin heavy chain gene enhancers. International Immunology. PMID 30407507 DOI: 10.1093/Intimm/Dxy074  0.44
2018 Pape KA, Maul RW, Dileepan T, Paustian AS, Gearhart PJ, Jenkins MK. Naive B Cells with High-Avidity Germline-Encoded Antigen Receptors Produce Persistent IgM and Transient IgG Memory B Cells. Immunity. PMID 29884459 DOI: 10.1016/J.Immuni.2018.04.019  0.44
2018 Castiblanco DP, Norton DD, Maul RW, Gearhart PJ. J6 downstream intronic sequence is dispensable for RNA polymerase II accumulation and somatic hypermutation of the variable gene in Ramos cells. Molecular Immunology. 97: 101-108. PMID 29625296 DOI: 10.1016/J.Molimm.2018.03.031  0.44
2018 Gearhart PJ, Mock BA, Casellas R, Cancro MP. The Reign of Antibodies: A Celebration of and Tribute to Michael Potter and His Homogeneous Immunoglobulin Workshops. Journal of Immunology (Baltimore, Md. : 1950). 200: 23-26. PMID 29255086 DOI: 10.4049/Jimmunol.1701516  1
2017 Castiblanco DP, Maul RW, Russell Knode LM, Gearhart PJ. Co-Stimulation of BCR and Toll-Like Receptor 7 Increases Somatic Hypermutation, Memory B Cell Formation, and Secondary Antibody Response to Protein Antigen. Frontiers in Immunology. 8: 1833. PMID 29312329 DOI: 10.3389/Fimmu.2017.01833  0.52
2017 Myles A, Gearhart PJ, Cancro MP. Signals that drive T-bet expression in B cells. Cellular Immunology. PMID 28923237 DOI: 10.1016/J.Cellimm.2017.09.004  1
2017 Russell Knode LM, Naradikian MS, Myles A, Scholz JL, Hao Y, Liu D, Ford ML, Tobias JW, Cancro MP, Gearhart PJ. Age-Associated B Cells Express a Diverse Repertoire of VH and Vκ Genes with Somatic Hypermutation. Journal of Immunology (Baltimore, Md. : 1950). PMID 28093524 DOI: 10.4049/Jimmunol.1601106  1
2017 Maul RW, Chon H, Sakhuja K, Cerritelli SM, Gugliotti LA, Gearhart PJ, Crouch RJ. R-Loop Depletion by Over-expressed RNase H1 in Mouse B Cells Increases Activation-Induced Deaminase Access to the Transcribed Strand without Altering Frequency of Isotype Switching. Journal of Molecular Biology. PMID 28065739 DOI: 10.1016/J.Jmb.2016.12.020  0.44
2016 Maul RW, MacCarthy T, Frank EG, Donigan KA, McLenigan MP, Yang W, Saribasak H, Huston DE, Lange SS, Woodgate R, Gearhart PJ. DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes. The Journal of Experimental Medicine. PMID 27455952 DOI: 10.1084/Jem.20151227  0.68
2016 Hurwitz JL, Penkert RR, Xu B, Fan Y, Partridge JF, Maul RW, Gearhart PJ. Hotspots for Vitamin-Steroid-Thyroid Hormone Response Elements Within Switch Regions of Immunoglobulin Heavy Chain Loci Predict a Direct Influence of Vitamins and Hormones on B Cell Class Switch Recombination. Viral Immunology. PMID 26741514 DOI: 10.1089/Vim.2015.0104  0.68
2016 Zanotti KJ, Gearhart PJ. Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases. Dna Repair. 38: 110-6. PMID 26719140 DOI: 10.1016/J.Dnarep.2015.11.011  0.68
2015 Gearhart PJ, Castiblanco DP, Russell Knode LM. Exceptional Antibodies Produced by Successive Immunizations. Plos Biology. 13: e1002321. PMID 26641938 DOI: 10.1371/journal.pbio.1002321  0.52
2015 Hathcock KS, Padilla-Nash HM, Camps J, Shin DM, Triner D, Shaffer AL, Maul RW, Steinberg SM, Gearhart PJ, Staudt LM, Morse HC, Ried T, Hodes RJ. ATM deficiency in absence of T cells promotes development of NF-kB-dependent murine B cell lymphomas that resemble human ABC DLBCL. Blood. PMID 26400962 DOI: 10.1182/Blood-2015-06-654749  0.68
2015 Maul RW, Saribasak H, Cao Z, Gearhart PJ. Topoisomerase I deficiency causes RNA polymerase II accumulation and increases AID abundance in immunoglobulin variable genes. Dna Repair. 30: 46-52. PMID 25869824 DOI: 10.1016/J.Dnarep.2015.03.004  0.68
2015 Vallabhaneni H, Zhou F, Maul RW, Sarkar J, Yin J, Lei M, Harrington L, Gearhart PJ, Liu Y. Defective repair of uracil causes telomere defects in mouse hematopoietic cells. The Journal of Biological Chemistry. 290: 5502-11. PMID 25572391 DOI: 10.1074/Jbc.M114.607101  0.68
2015 Zanotti KJ, Maul RW, Castiblanco DP, Yang W, Choi YJ, Fox JT, Myung K, Saribasak H, Gearhart PJ. ATAD5 deficiency decreases B cell division and Igh recombination. Journal of Immunology (Baltimore, Md. : 1950). 194: 35-42. PMID 25404367 DOI: 10.4049/Jimmunol.1401158  0.68
2014 Maul RW, Cao Z, Venkataraman L, Giorgetti CA, Press JL, Denizot Y, Du H, Sen R, Gearhart PJ. Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells. The Journal of Experimental Medicine. 211: 2297-306. PMID 25288395 DOI: 10.1084/Jem.20131512  0.68
2014 Maul RW, Gearhart PJ. Refining the Neuberger model: Uracil processing by activated B cells. European Journal of Immunology. 44: 1913-6. PMID 24920531 DOI: 10.1002/Eji.201444813  0.68
2014 Gearhart PJ, Kelsoe G. A tribute to Michael S. Neuberger. The Journal of Clinical Investigation. 124: 3-5. PMID 24382382 DOI: 10.1172/Jci74366  0.68
2012 Saribasak H, Gearhart PJ. Does DNA repair occur during somatic hypermutation? Seminars in Immunology. 24: 287-92. PMID 22728014 DOI: 10.1016/j.smim.2012.05.002  0.44
2012 Saribasak H, Maul RW, Cao Z, Yang WW, Schenten D, Kracker S, Gearhart PJ. DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions. The Journal of Experimental Medicine. 209: 1075-81. PMID 22615128 DOI: 10.1084/Jem.20112234  0.68
2011 Saribasak H, Maul RW, Cao Z, McClure RL, Yang W, McNeill DR, Wilson DM, Gearhart PJ. XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes. The Journal of Experimental Medicine. 208: 2209-16. PMID 21967769 DOI: 10.1084/Jem.20111135  0.68
2011 Cole LE, Mann BJ, Shirey KA, Richard K, Yang Y, Gearhart PJ, Chesko KL, Viscardi RM, Vogel SN. Role of TLR signaling in Francisella tularensis-LPS-induced, antibody-mediated protection against Francisella tularensis challenge. Journal of Leukocyte Biology. 90: 787-97. PMID 21750122 DOI: 10.1189/Jlb.0111014  0.68
2011 Pape KA, Taylor JJ, Maul RW, Gearhart PJ, Jenkins MK. Different B cell populations mediate early and late memory during an endogenous immune response. Science (New York, N.Y.). 331: 1203-7. PMID 21310965 DOI: 10.1126/Science.1201730  0.68
2011 Maul RW, Saribasak H, Martomo SA, McClure RL, Yang W, Vaisman A, Gramlich HS, Schatz DG, Woodgate R, Wilson DM, Gearhart PJ. Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions. Nature Immunology. 12: 70-6. PMID 21151102 DOI: 10.1038/Ni.1970  0.68
2010 Kohli RM, Maul RW, Guminski AF, McClure RL, Gajula KS, Saribasak H, McMahon MA, Siliciano RF, Gearhart PJ, Stivers JT. Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification. The Journal of Biological Chemistry. 285: 40956-64. PMID 20929867 DOI: 10.1074/Jbc.M110.177402  0.68
2010 Maul RW, Gearhart PJ. AID and somatic hypermutation. Advances in Immunology. 105: 159-91. PMID 20510733 DOI: 10.1016/S0065-2776(10)05006-6  0.68
2010 Maul RW, Gearhart PJ. Controlling somatic hypermutation in immunoglobulin variable and switch regions. Immunologic Research. 47: 113-22. PMID 20082153 DOI: 10.1007/S12026-009-8142-5  0.68
2009 Kohli RM, Abrams SR, Gajula KS, Maul RW, Gearhart PJ, Stivers JT. A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase. The Journal of Biological Chemistry. 284: 22898-904. PMID 19561087 DOI: 10.1074/Jbc.M109.025536  0.68
2009 Rajagopal D, Maul RW, Ghosh A, Chakraborty T, Khamlichi AA, Sen R, Gearhart PJ. Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation. The Journal of Experimental Medicine. 206: 1237-44. PMID 19433618 DOI: 10.1084/Jem.20082514  0.68
2009 Maul RW, Gearhart PJ. Women, autoimmunity, and cancer: a dangerous liaison between estrogen and activation-induced deaminase? The Journal of Experimental Medicine. 206: 11-3. PMID 19139165 DOI: 10.1084/Jem.20080086  0.68
2009 Saribasak H, Rajagopal D, Maul RW, Gearhart PJ. Hijacked DNA repair proteins and unchained DNA polymerases. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 364: 605-11. PMID 19008198 DOI: 10.1098/Rstb.2008.0188  0.68
2009 Gearhart PJ, Lindahl T, Neuberger MS. Preface. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 364: 561-2. PMID 19008190 DOI: 10.1098/rstb.2008.0236  0.68
2008 Gearhart PJ, Sen R. Regulating antibody diversity: taming a mutagen. Molecular Cell. 31: 615-6. PMID 18775319 DOI: 10.1016/j.molcel.2008.08.016  0.68
2008 Martomo SA, Saribasak H, Yokoi M, Hanaoka F, Gearhart PJ. Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes. Dna Repair. 7: 1603-8. PMID 18485835 DOI: 10.1016/j.dnarep.2008.04.002  0.68
2006 Martomo SA, Yang WW, Vaisman A, Maas A, Yokoi M, Hoeijmakers JH, Hanaoka F, Woodgate R, Gearhart PJ. Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota. Dna Repair. 5: 392-8. PMID 16443401 DOI: 10.1016/j.dnarep.2005.12.006  0.68
2005 Seki M, Gearhart PJ, Wood RD. DNA polymerases and somatic hypermutation of immunoglobulin genes. Embo Reports. 6: 1143-8. PMID 16319960 DOI: 10.1038/Sj.Embor.7400582  0.68
2005 Martomo SA, Fu D, Yang WW, Joshi NS, Gearhart PJ. Deoxyuridine is generated preferentially in the nontranscribed strand of DNA from cells expressing activation-induced cytidine deaminase. Journal of Immunology (Baltimore, Md. : 1950). 174: 7787-91. PMID 15944282  0.68
2005 Martomo SA, Yang WW, Wersto RP, Ohkumo T, Kondo Y, Yokoi M, Masutani C, Hanaoka F, Gearhart PJ. Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification. Proceedings of the National Academy of Sciences of the United States of America. 102: 8656-61. PMID 15939880 DOI: 10.1073/pnas.0501852102  0.68
2004 Lumsden JM, McCarty T, Petiniot LK, Shen R, Barlow C, Wynn TA, Morse HC, Gearhart PJ, Wynshaw-Boris A, Max EE, Hodes RJ. Immunoglobulin class switch recombination is impaired in Atm-deficient mice. The Journal of Experimental Medicine. 200: 1111-21. PMID 15504820 DOI: 10.1084/Jem.20041074  0.68
2003 McDonald JP, Frank EG, Plosky BS, Rogozin IB, Masutani C, Hanaoka F, Woodgate R, Gearhart PJ. 129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation. The Journal of Experimental Medicine. 198: 635-43. PMID 12925679 DOI: 10.1084/jem.20030767  0.68
2003 Winter DB, Phung QH, Zeng X, Seeberg E, Barnes DE, Lindahl T, Gearhart PJ. Normal somatic hypermutation of Ig genes in the absence of 8-hydroxyguanine-DNA glycosylase. Journal of Immunology (Baltimore, Md. : 1950). 170: 5558-62. PMID 12759433  0.68
2001 Gearhart PJ, Wood RD. Emerging links between hypermutation of antibody genes and DNA polymerases Nature Reviews Immunology. 1: 187-192. PMID 11905827 DOI: 10.1038/35105009  0.68
2001 Zeng X, Winter DB, Kasmer C, Kraemer KH, Lehmann AR, Gearhart PJ. DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Nature Immunology. 2: 537-41. PMID 11376341 DOI: 10.1038/88740  0.68
1998 Phung QH, Winter DB, Cranston A, Tarone RE, Bohr VA, Fishel R, Gearhart PJ. Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein Journal of Experimental Medicine. 187: 1745-1750. PMID 9607916 DOI: 10.1084/jem.187.11.1745  0.68
1989 Lawler AM, Kearney JF, Kuehl M, Gearhart PJ. Early rearrangements of genes encoding murine immunoglobulin kappa chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus Proceedings of the National Academy of Sciences of the United States of America. 86: 6744-6748. PMID 2505260 DOI: 10.1073/Pnas.86.17.6744  0.68
1987 Lawler AM, Lin PS, Gearhart PJ. Adult B-cell repertoire is biased toward two heavy-chain variable-region genes that rearrange frequently in fetal pre-B cells Proceedings of the National Academy of Sciences of the United States of America. 84: 2454-2458. PMID 3104915 DOI: 10.1073/pnas.84.8.2454  0.68
1984 Perlmutter RM, Crews ST, Douglas R, Sorensen G, Johnson N, Nivera N, Gearhart PJ, Hood L. The generation of diversity in phosphorylcholine-binding antibodies. Advances in Immunology. 35: 1-37. PMID 6431763 DOI: 10.1016/S0065-2776(08)60572-6  0.68
1983 Gearhart PJ, Bogenhagen DF. Clusters of point mutations are found exclusively around rearranged antibody variable genes Proceedings of the National Academy of Sciences of the United States of America. 80: 3439-3443. PMID 6222379 DOI: 10.1073/pnas.80.11.3439  0.68
1981 Gearhart PJ, Johnson ND, Douglas R, Hood L. IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts. Nature. 291: 29-34. PMID 7231520 DOI: 10.1038/291029a0  0.68
1981 Pierce SK, Speck NA, Gleason K, Gearhart PJ, Köhler H. BALB/c T cells have the potential to recognize the TEPC 15 prototype antibody and its somatic variants Journal of Experimental Medicine. 154: 1178-1187. PMID 6974760 DOI: 10.1084/Jem.154.4.1178  0.68
1980 Gearhart PJ, Hurwitz JL, Cebra JJ. Successive switching of antibody isotypes expressed within the lines of a B-cell clone. Proceedings of the National Academy of Sciences of the United States of America. 77: 5424-8. PMID 6776537 DOI: 10.1073/pnas.77.9.5424  0.68
1979 Gearhart PJ, Cebra JJ. Differentiated B lymphocytes. Potential to express particular antibody variable and constant regions depends on site of lymphoid tissue and antigen load. The Journal of Experimental Medicine. 149: 216-27. PMID 105075 DOI: 10.1084/Jem.149.1.216  0.68
1978 Gearhart PJ, Cebra JJ. Idiotype sharing by murine strains differing in immunoglobulin allotype. Nature. 272: 264-5. PMID 415255 DOI: 10.1038/272264A0  0.68
1978 Cebra JJ, Emmons R, Gearhart PJ, Robertson SM, Tseng J. Cellular parameters of the IgA response. Advances in Experimental Medicine and Biology. 107: 19-28. PMID 311137 DOI: 10.1007/978-1-4684-3369-2_3  0.68
1977 Cebra JJ, Gearhart PJ, Kamat R, Robertson SM, Tseng J. The secretory immunoglobulin A response in the gut [proceedings]. Biochemical Society Transactions. 5: 1565-9. PMID 923983 DOI: 10.1042/Bst0051565  0.68
1977 Cebra JJ, Kamat R, Gearhart P, Robertson SM, Tseng J. The secretory IgA system of the gut. Ciba Foundation Symposium. 5-28. PMID 346328 DOI: 10.1002/9780470720288.ch2  0.68
1977 Accolla RS, Gearhart PJ, Sigal NH, Cancro MP, Klinman NR. Idiotype-specific neonatal suppression of phosphorylcholine-responsive B cells. European Journal of Immunology. 7: 876-81. PMID 75802 DOI: 10.1002/Eji.1830071211  0.68
1977 Cebra JJ, Gearhart PJ, Kamat R, Robertson SM, Tseng J. Origin and differentiation of lymphocytes involved in the secretory IgA responses. Cold Spring Harbor Symposia On Quantitative Biology. 41: 201-15. PMID 70311 DOI: 10.1101/Sqb.1977.041.01.026  0.68
1977 Gearhart PJ, Sigal NH, Klinman NR. The monoclonal anti phosphorylcholine antibody response in several murine strains: genetic implications of a diverse repertoire Journal of Experimental Medicine. 145: 876-891. PMID 67172 DOI: 10.1084/Jem.145.4.876  0.68
1976 Klinman NR, Sigal NH, Metcalf ES, Pierce SK, Gearhart PJ. The interplay of evolution and environment in B cell diversification Origins of Lymphocyte Diversity Cold Spring Harbor Symposia On Quantitative Biology. 41: 165-173. PMID 70310 DOI: 10.1101/Sqb.1977.041.01.022  0.68
1975 Gearhart PJ, Sigal NH, Klinman NR. Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell Proceedings of the National Academy of Sciences of the United States of America. 72: 1707-1711. PMID 1080568 DOI: 10.1073/Pnas.72.5.1707  0.68
1975 Gearhart PJ, Sigal NH, Klinman NR. Heterogeneity of the BALB/c antiphosphorylcholine antibody response at the precursor cell level Journal of Experimental Medicine. 141: 56-71. PMID 46913 DOI: 10.1084/Jem.141.1.56  0.68
Show low-probability matches.