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Patricia Gearhart - Publications

Affiliations: 
Molecular Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
Immunology
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55/123 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Taylor JA, Hutchinson MA, Gearhart PJ, Maul RW. Antibodies in action: the role of humoral immunity in the fight against atherosclerosis. Immunity & Ageing : I & A. 19: 59. PMID 36461105 DOI: 10.1186/s12979-022-00316-6  0.432
2021 Hutchinson MA, Park HS, Zanotti KJ, Alvarez-Gonzalez J, Zhang J, Zhang L, Telljohann R, Wang M, Lakatta EG, Gearhart PJ, Maul RW. Auto-Antibody Production During Experimental Atherosclerosis in Mice. Frontiers in Immunology. 12: 695220. PMID 34305930 DOI: 10.3389/fimmu.2021.695220  0.334
2021 Alvarez-Gonzalez J, Yasgar A, Maul RW, Rieffer AE, Crawford DJ, Salamango DJ, Dorjsuren D, Zakharov AV, Jansen DJ, Rai G, Marugan J, Simeonov A, Harris RS, Kohli RM, Gearhart PJ. Small Molecule Inhibitors of Activation-Induced Deaminase Decrease Class Switch Recombination in B Cells. Acs Pharmacology & Translational Science. 4: 1214-1226. PMID 34151211 DOI: 10.1021/acsptsci.1c00064  0.387
2021 Maul RW, Catalina MD, Kumar V, Bachali P, Grammer AC, Wang S, Yang W, Hasni S, Ettinger R, Lipsky PE, Gearhart PJ. Transcriptome and IgH Repertoire Analyses Show That CD11c B Cells Are a Distinct Population With Similarity to B Cells Arising in Autoimmunity and Infection. Frontiers in Immunology. 12: 649458. PMID 33815408 DOI: 10.3389/fimmu.2021.649458  0.417
2019 Russell Knode LM, Park HS, Maul RW, Gearhart PJ. B cells from young and old mice switch isotypes with equal frequencies after ex vivo stimulation. Cellular Immunology. 103966. PMID 31447053 DOI: 10.1016/J.Cellimm.2019.103966  0.402
2018 Jones BG, Sealy RE, Penkert RR, Surman SL, Maul RW, Neale G, Xu B, Gearhart PJ, Hurwitz JL. Complex sex-biased antibody responses: Estrogen receptors bind estrogen response elements centered within immunoglobulin heavy chain gene enhancers. International Immunology. PMID 30407507 DOI: 10.1093/Intimm/Dxy074  0.312
2018 Pape KA, Maul RW, Dileepan T, Paustian AS, Gearhart PJ, Jenkins MK. Naive B Cells with High-Avidity Germline-Encoded Antigen Receptors Produce Persistent IgM and Transient IgG Memory B Cells. Immunity. PMID 29884459 DOI: 10.1016/J.Immuni.2018.04.019  0.389
2018 Castiblanco DP, Norton DD, Maul RW, Gearhart PJ. J6 downstream intronic sequence is dispensable for RNA polymerase II accumulation and somatic hypermutation of the variable gene in Ramos cells. Molecular Immunology. 97: 101-108. PMID 29625296 DOI: 10.1016/J.Molimm.2018.03.031  0.311
2018 Gearhart PJ, Mock BA, Casellas R, Cancro MP. The Reign of Antibodies: A Celebration of and Tribute to Michael Potter and His Homogeneous Immunoglobulin Workshops. Journal of Immunology (Baltimore, Md. : 1950). 200: 23-26. PMID 29255086 DOI: 10.4049/Jimmunol.1701516  0.626
2017 Castiblanco DP, Maul RW, Russell Knode LM, Gearhart PJ. Co-Stimulation of BCR and Toll-Like Receptor 7 Increases Somatic Hypermutation, Memory B Cell Formation, and Secondary Antibody Response to Protein Antigen. Frontiers in Immunology. 8: 1833. PMID 29312329 DOI: 10.3389/Fimmu.2017.01833  0.425
2017 Myles A, Gearhart PJ, Cancro MP. Signals that drive T-bet expression in B cells. Cellular Immunology. PMID 28923237 DOI: 10.1016/J.Cellimm.2017.09.004  0.688
2017 Russell Knode LM, Naradikian MS, Myles A, Scholz JL, Hao Y, Liu D, Ford ML, Tobias JW, Cancro MP, Gearhart PJ. Age-Associated B Cells Express a Diverse Repertoire of VH and Vκ Genes with Somatic Hypermutation. Journal of Immunology (Baltimore, Md. : 1950). PMID 28093524 DOI: 10.4049/Jimmunol.1601106  0.708
2016 Jones BG, Penkert RR, Xu B, Fan Y, Neale G, Gearhart PJ, Hurwitz JL. Binding of estrogen receptors to switch sites and regulatory elements in the immunoglobulin heavy chain locus of activated B cells suggests a direct influence of estrogen on antibody expression. Molecular Immunology. 77: 97-102. PMID 27494228 DOI: 10.1016/J.Molimm.2016.07.015  0.335
2016 Zanotti KJ, Gearhart PJ. Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases. Dna Repair. 38: 110-6. PMID 26719140 DOI: 10.1016/J.Dnarep.2015.11.011  0.389
2015 Gearhart PJ, Castiblanco DP, Russell Knode LM. Exceptional Antibodies Produced by Successive Immunizations. Plos Biology. 13: e1002321. PMID 26641938 DOI: 10.1371/journal.pbio.1002321  0.414
2015 Hathcock KS, Padilla-Nash HM, Camps J, Shin DM, Triner D, Shaffer AL, Maul RW, Steinberg SM, Gearhart PJ, Staudt LM, Morse HC, Ried T, Hodes RJ. ATM deficiency in absence of T cells promotes development of NF-kB-dependent murine B cell lymphomas that resemble human ABC DLBCL. Blood. PMID 26400962 DOI: 10.1182/Blood-2015-06-654749  0.401
2015 Maul RW, Saribasak H, Cao Z, Gearhart PJ. Topoisomerase I deficiency causes RNA polymerase II accumulation and increases AID abundance in immunoglobulin variable genes. Dna Repair. 30: 46-52. PMID 25869824 DOI: 10.1016/J.Dnarep.2015.03.004  0.314
2015 Zanotti KJ, Maul RW, Castiblanco DP, Yang W, Choi YJ, Fox JT, Myung K, Saribasak H, Gearhart PJ. ATAD5 deficiency decreases B cell division and Igh recombination. Journal of Immunology (Baltimore, Md. : 1950). 194: 35-42. PMID 25404367 DOI: 10.4049/Jimmunol.1401158  0.438
2014 Maul RW, Cao Z, Venkataraman L, Giorgetti CA, Press JL, Denizot Y, Du H, Sen R, Gearhart PJ. Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells. The Journal of Experimental Medicine. 211: 2297-306. PMID 25288395 DOI: 10.1084/Jem.20131512  0.72
2014 Maul RW, Gearhart PJ. Refining the Neuberger model: Uracil processing by activated B cells. European Journal of Immunology. 44: 1913-6. PMID 24920531 DOI: 10.1002/Eji.201444813  0.414
2014 Gearhart PJ, Kelsoe G. A tribute to Michael S. Neuberger. The Journal of Clinical Investigation. 124: 3-5. PMID 24382382 DOI: 10.1172/Jci74366  0.456
2011 Saribasak H, Maul RW, Cao Z, McClure RL, Yang W, McNeill DR, Wilson DM, Gearhart PJ. XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes. The Journal of Experimental Medicine. 208: 2209-16. PMID 21967769 DOI: 10.1084/Jem.20111135  0.357
2011 Pape KA, Taylor JJ, Maul RW, Gearhart PJ, Jenkins MK. Different B cell populations mediate early and late memory during an endogenous immune response. Science (New York, N.Y.). 331: 1203-7. PMID 21310965 DOI: 10.1126/Science.1201730  0.331
2010 Maul RW, Gearhart PJ. AID and somatic hypermutation. Advances in Immunology. 105: 159-91. PMID 20510733 DOI: 10.1016/S0065-2776(10)05006-6  0.386
2010 Maul RW, Gearhart PJ. Controlling somatic hypermutation in immunoglobulin variable and switch regions. Immunologic Research. 47: 113-22. PMID 20082153 DOI: 10.1007/S12026-009-8142-5  0.309
2009 Rajagopal D, Maul RW, Ghosh A, Chakraborty T, Khamlichi AA, Sen R, Gearhart PJ. Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation. The Journal of Experimental Medicine. 206: 1237-44. PMID 19433618 DOI: 10.1084/Jem.20082514  0.69
2009 Saribasak H, Rajagopal D, Maul RW, Gearhart PJ. Hijacked DNA repair proteins and unchained DNA polymerases. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 364: 605-11. PMID 19008198 DOI: 10.1098/Rstb.2008.0188  0.697
2005 Martomo SA, Fu D, Yang WW, Joshi NS, Gearhart PJ. Deoxyuridine is generated preferentially in the nontranscribed strand of DNA from cells expressing activation-induced cytidine deaminase. Journal of Immunology (Baltimore, Md. : 1950). 174: 7787-91. PMID 15944282  0.306
2005 Martomo SA, Yang WW, Wersto RP, Ohkumo T, Kondo Y, Yokoi M, Masutani C, Hanaoka F, Gearhart PJ. Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification. Proceedings of the National Academy of Sciences of the United States of America. 102: 8656-61. PMID 15939880 DOI: 10.1073/pnas.0501852102  0.387
2005 Wilson TM, Vaisman A, Martomo SA, Sullivan P, Lan L, Hanaoka F, Yasui A, Woodgate R, Gearhart PJ. MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes. The Journal of Experimental Medicine. 201: 637-45. PMID 15710654 DOI: 10.1084/jem.20042066  0.354
2004 Lumsden JM, McCarty T, Petiniot LK, Shen R, Barlow C, Wynn TA, Morse HC, Gearhart PJ, Wynshaw-Boris A, Max EE, Hodes RJ. Immunoglobulin class switch recombination is impaired in Atm-deficient mice. The Journal of Experimental Medicine. 200: 1111-21. PMID 15504820 DOI: 10.1084/Jem.20041074  0.508
2003 Gearhart PJ. B cells pay a price. Oncogene. 22: 5379-80. PMID 12934096 DOI: 10.1038/sj.onc.1206874  0.317
2003 Winter DB, Phung QH, Zeng X, Seeberg E, Barnes DE, Lindahl T, Gearhart PJ. Normal somatic hypermutation of Ig genes in the absence of 8-hydroxyguanine-DNA glycosylase. Journal of Immunology (Baltimore, Md. : 1950). 170: 5558-62. PMID 12759433  0.355
2001 Winter DB, Gearhart PJ. Altered spectra of hypermutation in DNA repair-deficient mice. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 356: 5-11. PMID 11205330 DOI: 10.1098/rstb.2000.0742  0.363
2000 Winter DB, Phung QH, Wood RD, Gearhart PJ. Differential expression of DNA polymerase epsilon in resting and activated B lymphocytes is consistent with an in vivo role in replication and not repair. Molecular Immunology. 37: 125-31. PMID 10865111 DOI: 10.1016/S0161-5890(00)00040-7  0.381
1998 Phung QH, Winter DB, Cranston A, Tarone RE, Bohr VA, Fishel R, Gearhart PJ. Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein Journal of Experimental Medicine. 187: 1745-1750. PMID 9607916 DOI: 10.1084/jem.187.11.1745  0.307
1997 Winter DB, Sattar N, Mai JJ, Gearhart PJ. Insertion of 2 kb of bacteriophage DNA between an immunoglobulin promoter and leader exon stops somatic hypermutation in a kappa transgene. Molecular Immunology. 34: 359-66. PMID 9293769 DOI: 10.1016/S0161-5890(97)00073-4  0.311
1995 Umar A, Gearhart PJ. Reciprocal homologous recombination in or near antibody VDJ genes. European Journal of Immunology. 25: 2392-400. PMID 7664801 DOI: 10.1002/eji.1830250840  0.316
1987 Malipiero UV, Levy NS, Gearhart PJ. Somatic mutation in anti-phosphorylcholine antibodies. Immunological Reviews. 96: 59-74. PMID 3298010 DOI: 10.1111/j.1600-065X.1987.tb00509.x  0.327
1987 Lawler AM, Lin PS, Gearhart PJ. Adult B-cell repertoire is biased toward two heavy-chain variable-region genes that rearrange frequently in fetal pre-B cells Proceedings of the National Academy of Sciences of the United States of America. 84: 2454-2458. PMID 3104915 DOI: 10.1073/pnas.84.8.2454  0.391
1984 Gearhart PJ. The adaptable somatic repertoire. Annales D'Immunologie. 137-42. PMID 6424549 DOI: 10.1016/S0769-2625(84)80023-9  0.354
1981 Gearhart PJ, Johnson ND, Douglas R, Hood L. IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts. Nature. 291: 29-34. PMID 7231520 DOI: 10.1038/291029a0  0.306
1981 Pierce SK, Speck NA, Gleason K, Gearhart PJ, Köhler H. BALB/c T cells have the potential to recognize the TEPC 15 prototype antibody and its somatic variants Journal of Experimental Medicine. 154: 1178-1187. PMID 6974760 DOI: 10.1084/Jem.154.4.1178  0.589
1980 Gearhart PJ, Hurwitz JL, Cebra JJ. Successive switching of antibody isotypes expressed within the lines of a B-cell clone. Proceedings of the National Academy of Sciences of the United States of America. 77: 5424-8. PMID 6776537 DOI: 10.1073/pnas.77.9.5424  0.473
1979 Gearhart PJ, Cebra JJ. Differentiated B lymphocytes. Potential to express particular antibody variable and constant regions depends on site of lymphoid tissue and antigen load. The Journal of Experimental Medicine. 149: 216-27. PMID 105075 DOI: 10.1084/Jem.149.1.216  0.48
1978 Gearhart PJ, Cebra JJ. Idiotype sharing by murine strains differing in immunoglobulin allotype. Nature. 272: 264-5. PMID 415255 DOI: 10.1038/272264A0  0.33
1978 Cebra JJ, Emmons R, Gearhart PJ, Robertson SM, Tseng J. Cellular parameters of the IgA response. Advances in Experimental Medicine and Biology. 107: 19-28. PMID 311137 DOI: 10.1007/978-1-4684-3369-2_3  0.341
1977 Cebra JJ, Gearhart PJ, Kamat R, Robertson SM, Tseng J. The secretory immunoglobulin A response in the gut [proceedings]. Biochemical Society Transactions. 5: 1565-9. PMID 923983 DOI: 10.1042/Bst0051565  0.373
1977 Cebra JJ, Kamat R, Gearhart P, Robertson SM, Tseng J. The secretory IgA system of the gut. Ciba Foundation Symposium. 5-28. PMID 346328 DOI: 10.1002/9780470720288.ch2  0.396
1977 Accolla RS, Gearhart PJ, Sigal NH, Cancro MP, Klinman NR. Idiotype-specific neonatal suppression of phosphorylcholine-responsive B cells. European Journal of Immunology. 7: 876-81. PMID 75802 DOI: 10.1002/Eji.1830071211  0.74
1977 Cebra JJ, Gearhart PJ, Kamat R, Robertson SM, Tseng J. Origin and differentiation of lymphocytes involved in the secretory IgA responses. Cold Spring Harbor Symposia On Quantitative Biology. 41: 201-15. PMID 70311 DOI: 10.1101/Sqb.1977.041.01.026  0.356
1977 Gearhart PJ, Sigal NH, Klinman NR. The monoclonal anti phosphorylcholine antibody response in several murine strains: genetic implications of a diverse repertoire Journal of Experimental Medicine. 145: 876-891. PMID 67172 DOI: 10.1084/Jem.145.4.876  0.654
1976 Klinman NR, Sigal NH, Metcalf ES, Pierce SK, Gearhart PJ. The interplay of evolution and environment in B cell diversification Origins of Lymphocyte Diversity Cold Spring Harbor Symposia On Quantitative Biology. 41: 165-173. PMID 70310 DOI: 10.1101/Sqb.1977.041.01.022  0.738
1975 Gearhart PJ, Sigal NH, Klinman NR. Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell Proceedings of the National Academy of Sciences of the United States of America. 72: 1707-1711. PMID 1080568 DOI: 10.1073/Pnas.72.5.1707  0.669
1975 Gearhart PJ, Sigal NH, Klinman NR. Heterogeneity of the BALB/c antiphosphorylcholine antibody response at the precursor cell level Journal of Experimental Medicine. 141: 56-71. PMID 46913 DOI: 10.1084/Jem.141.1.56  0.697
Low-probability matches (unlikely to be authored by this person)
2017 Maul RW, Chon H, Sakhuja K, Cerritelli SM, Gugliotti LA, Gearhart PJ, Crouch RJ. R-Loop Depletion by Over-expressed RNase H1 in Mouse B Cells Increases Activation-Induced Deaminase Access to the Transcribed Strand without Altering Frequency of Isotype Switching. Journal of Molecular Biology. PMID 28065739 DOI: 10.1016/J.Jmb.2016.12.020  0.298
2006 Martomo SA, Yang WW, Vaisman A, Maas A, Yokoi M, Hoeijmakers JH, Hanaoka F, Woodgate R, Gearhart PJ. Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota. Dna Repair. 5: 392-8. PMID 16443401 DOI: 10.1016/j.dnarep.2005.12.006  0.293
2019 Heltzel JMH, Gearhart PJ. What Targets Somatic Hypermutation to the Immunoglobulin Loci? Viral Immunology. PMID 31770070 DOI: 10.1089/vim.2019.0149  0.29
2008 Martomo SA, Saribasak H, Yokoi M, Hanaoka F, Gearhart PJ. Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes. Dna Repair. 7: 1603-8. PMID 18485835 DOI: 10.1016/j.dnarep.2008.04.002  0.289
2001 Gearhart PJ, Wood RD. Emerging links between hypermutation of antibody genes and DNA polymerases Nature Reviews Immunology. 1: 187-192. PMID 11905827 DOI: 10.1038/35105009  0.289
2001 Rosner K, Winter DB, Tarone RE, Skovgaard GL, Bohr VA, Gearhart PJ. Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes. Immunology. 103: 179-87. PMID 11412305 DOI: 10.1046/j.1365-2567.2001.01220.x  0.287
1991 Umar A, Schweitzer PA, Levy NS, Gearhart JD, Gearhart PJ. Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes. Proceedings of the National Academy of Sciences of the United States of America. 88: 4902-6. PMID 1905016 DOI: 10.1073/Pnas.88.11.4902  0.284
1998 Winter DB, Phung QH, Umar A, Baker SM, Tarone RE, Tanaka K, Liskay RM, Kunkel TA, Bohr VA, Gearhart PJ. Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2. Proceedings of the National Academy of Sciences of the United States of America. 95: 6953-8. PMID 9618520 DOI: 10.1073/Pnas.95.12.6953  0.284
2019 Zanotti KJ, Maul RW, Yang W, Gearhart PJ. DNA Breaks in Ig V Regions Are Predominantly Single Stranded and Are Generated by UNG and MSH6 DNA Repair Pathways. Journal of Immunology (Baltimore, Md. : 1950). PMID 30665938 DOI: 10.4049/Jimmunol.1801183  0.281
2005 Mayorov VI, Rogozin IB, Adkison LR, Gearhart PJ. DNA polymerase eta contributes to strand bias of mutations of A versus T in immunoglobulin genes. Journal of Immunology (Baltimore, Md. : 1950). 174: 7781-6. PMID 15944281  0.278
2020 Jones BG, Sealy RE, Penkert RR, Surman SL, Birshtein BK, Xu B, Neale G, Maul RW, Gearhart PJ, Hurwitz JL. From Influenza Virus Infections to Lupus: Synchronous Estrogen Receptor and RNA Polymerase II Binding Within the Immunoglobulin Heavy Chain Locus. Viral Immunology. PMID 32105583 DOI: 10.1089/Vim.2019.0144  0.276
2022 Heltzel JHM, Maul RW, Yang W, Gearhart PJ. Promoter Proximity Defines Mutation Window for V and V Genes Rearranged to Different J Genes. Journal of Immunology (Baltimore, Md. : 1950). 208: 2220-2226. PMID 35418469 DOI: 10.4049/jimmunol.2101002  0.273
2012 Saribasak H, Maul RW, Cao Z, Yang WW, Schenten D, Kracker S, Gearhart PJ. DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions. The Journal of Experimental Medicine. 209: 1075-81. PMID 22615128 DOI: 10.1084/Jem.20112234  0.273
2008 Gearhart PJ, Sen R. Regulating antibody diversity: taming a mutagen. Molecular Cell. 31: 615-6. PMID 18775319 DOI: 10.1016/j.molcel.2008.08.016  0.27
2011 Maul RW, Saribasak H, Martomo SA, McClure RL, Yang W, Vaisman A, Gramlich HS, Schatz DG, Woodgate R, Wilson DM, Gearhart PJ. Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions. Nature Immunology. 12: 70-6. PMID 21151102 DOI: 10.1038/Ni.1970  0.269
2001 Zeng X, Winter DB, Kasmer C, Kraemer KH, Lehmann AR, Gearhart PJ. DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Nature Immunology. 2: 537-41. PMID 11376341 DOI: 10.1038/88740  0.267
1989 Levy NS, Malipiero UV, Lebecque SG, Gearhart PJ. Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response. The Journal of Experimental Medicine. 169: 2007-19. PMID 2499654 DOI: 10.1084/jem.169.6.2007  0.265
2006 Gearhart PJ. Antibody wars: extreme diversity. Journal of Immunology (Baltimore, Md. : 1950). 177: 4235-6. PMID 16982852  0.265
2000 Wittschieben J, Shivji MK, Lalani E, Jacobs MA, Marini F, Gearhart PJ, Rosewell I, Stamp G, Wood RD. Disruption of the developmentally regulated Rev3l gene causes embryonic lethality. Current Biology : Cb. 10: 1217-20. PMID 11050392 DOI: 10.1016/S0960-9822(00)00725-9  0.264
1998 Winter DB, Gearhart PJ, Bohr VA. Homogeneous rate of degradation of nuclear DNA during apoptosis. Nucleic Acids Research. 26: 4422-5. PMID 9742244 DOI: 10.1093/nar/26.19.4422  0.263
2002 Gearhart PJ. Immunology: the roots of antibody diversity. Nature. 419: 29-31. PMID 12214221 DOI: 10.1038/419029a  0.262
2016 Maul RW, MacCarthy T, Frank EG, Donigan KA, McLenigan MP, Yang W, Saribasak H, Huston DE, Lange SS, Woodgate R, Gearhart PJ. DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes. The Journal of Experimental Medicine. PMID 27455952 DOI: 10.1084/Jem.20151227  0.26
1999 Alrefai RH, Beecham EJ, Bohr VA, Gearhart PJ. Less repair of pyrimidine dimers and single-strand breaks in genes by scid cells. Biochemical and Biophysical Research Communications. 264: 878-82. PMID 10544024 DOI: 10.1006/bbrc.1999.1608  0.26
2003 McDonald JP, Frank EG, Plosky BS, Rogozin IB, Masutani C, Hanaoka F, Woodgate R, Gearhart PJ. 129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation. The Journal of Experimental Medicine. 198: 635-43. PMID 12925679 DOI: 10.1084/jem.20030767  0.26
1984 Gearhart PJ. The effect of somatic mutation on antibody affinity. Annals of the New York Academy of Sciences. 418: 171-6. PMID 6608900 DOI: 10.1111/j.1749-6632.1983.tb18064.x  0.256
2001 Rosner K, Winter DB, Kasmer C, Skovgaard GL, Tarone RE, Bohr VA, Gearhart PJ. Impact of age on hypermutation of immunoglobulin variable genes in humans. Journal of Clinical Immunology. 21: 102-15. PMID 11332649 DOI: 10.1023/A:1011003821798  0.256
1998 Winter DB, Gearhart PJ. Dual enigma of somatic hypermutation of immunoglobulin variable genes: targeting and mechanism. Immunological Reviews. 162: 89-96. PMID 9602355 DOI: 10.1111/j.1600-065X.1998.tb01432.x  0.254
2016 Hurwitz JL, Penkert RR, Xu B, Fan Y, Partridge JF, Maul RW, Gearhart PJ. Hotspots for Vitamin-Steroid-Thyroid Hormone Response Elements Within Switch Regions of Immunoglobulin Heavy Chain Loci Predict a Direct Influence of Vitamins and Hormones on B Cell Class Switch Recombination. Viral Immunology. PMID 26741514 DOI: 10.1089/Vim.2015.0104  0.253
2005 Seki M, Gearhart PJ, Wood RD. DNA polymerases and somatic hypermutation of immunoglobulin genes. Embo Reports. 6: 1143-8. PMID 16319960 DOI: 10.1038/Sj.Embor.7400582  0.251
1989 Gearhart PJ, Lawler AM, Levy NS, Lebecque SG, Malipiero UV. Generation of antibody diversity before and after immunization. Annals of the New York Academy of Sciences. 546: 57-62. PMID 3150261 DOI: 10.1111/j.1749-6632.1988.tb21619.x  0.247
1989 Lawler AM, Kearney JF, Kuehl M, Gearhart PJ. Early rearrangements of genes encoding murine immunoglobulin kappa chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus Proceedings of the National Academy of Sciences of the United States of America. 86: 6744-6748. PMID 2505260 DOI: 10.1073/Pnas.86.17.6744  0.24
2009 Kohli RM, Abrams SR, Gajula KS, Maul RW, Gearhart PJ, Stivers JT. A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase. The Journal of Biological Chemistry. 284: 22898-904. PMID 19561087 DOI: 10.1074/Jbc.M109.025536  0.239
2004 Zeng X, Negrete GA, Kasmer C, Yang WW, Gearhart PJ. Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions. The Journal of Experimental Medicine. 199: 917-24. PMID 15051760 DOI: 10.1084/jem.20032022  0.237
2010 Kohli RM, Maul RW, Guminski AF, McClure RL, Gajula KS, Saribasak H, McMahon MA, Siliciano RF, Gearhart PJ, Stivers JT. Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification. The Journal of Biological Chemistry. 285: 40956-64. PMID 20929867 DOI: 10.1074/Jbc.M110.177402  0.235
1984 Perlmutter RM, Crews ST, Douglas R, Sorensen G, Johnson N, Nivera N, Gearhart PJ, Hood L. The generation of diversity in phosphorylcholine-binding antibodies. Advances in Immunology. 35: 1-37. PMID 6431763 DOI: 10.1016/S0065-2776(08)60572-6  0.229
2007 Alrefai RH, Winter DB, Bohr VA, Gearhart PJ. Nucleotide excision repair in an immunoglobulin variable gene is less efficient than in a housekeeping gene. Molecular Immunology. 44: 2800-5. PMID 17336386 DOI: 10.1016/j.molimm.2007.01.018  0.226
2009 Maul RW, Gearhart PJ. Women, autoimmunity, and cancer: a dangerous liaison between estrogen and activation-induced deaminase? The Journal of Experimental Medicine. 206: 11-3. PMID 19139165 DOI: 10.1084/Jem.20080086  0.226
1992 Lawler AM, Umar A, Gearhart PJ. Linkage of two pseudogenes from V kappa 1 and V kappa 9 murine immunoglobulin families. Molecular Immunology. 29: 295-301. PMID 1557040 DOI: 10.1016/0161-5890(92)90015-P  0.225
1983 Gearhart PJ, Bogenhagen DF. Clusters of point mutations are found exclusively around rearranged antibody variable genes Proceedings of the National Academy of Sciences of the United States of America. 80: 3439-3443. PMID 6222379 DOI: 10.1073/pnas.80.11.3439  0.22
1991 Lebecque SG, Gearhart PJ. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene. The Journal of Experimental Medicine. 172: 1717-27. PMID 2258702 DOI: 10.1084/jem.172.6.1717  0.218
2012 Saribasak H, Gearhart PJ. Does DNA repair occur during somatic hypermutation? Seminars in Immunology. 24: 287-92. PMID 22728014 DOI: 10.1016/j.smim.2012.05.002  0.216
2015 Vallabhaneni H, Zhou F, Maul RW, Sarkar J, Yin J, Lei M, Harrington L, Gearhart PJ, Liu Y. Defective repair of uracil causes telomere defects in mouse hematopoietic cells. The Journal of Biological Chemistry. 290: 5502-11. PMID 25572391 DOI: 10.1074/Jbc.M114.607101  0.212
2001 Frank EG, Tissier A, McDonald JP, Rapić-Otrin V, Zeng X, Gearhart PJ, Woodgate R. Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template. The Embo Journal. 20: 2914-22. PMID 11387224 DOI: 10.1093/emboj/20.11.2914  0.207
2022 Ursin RL, Dhakal S, Liu H, Jayaraman S, Park HS, Powell HR, Sherer ML, Littlefield KE, Fink AL, Ma Z, Mueller AL, Chen AP, Seddu K, Woldetsadik YA, Gearhart PJ, et al. Greater Breadth of Vaccine-Induced Immunity in Females than Males Is Mediated by Increased Antibody Diversity in Germinal Center B Cells. Mbio. e0183922. PMID 35856618 DOI: 10.1128/mbio.01839-22  0.196
1988 LEBECQUE SG, LEVY NS, MALIPIERO UV, GEARHART PJ. Different Frequencies of Mutation in Immunoglobulin Genes after Primary Immunization with PC-KLH Annals of the New York Academy of Sciences. 546: 253-254. DOI: 10.1111/j.1749-6632.1988.tb21658.x  0.195
2008 Heltemes-Harris LM, Gearhart PJ, Ghosh P, Longo DL. Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashion. Molecular Immunology. 45: 1799-806. PMID 17983655 DOI: 10.1016/j.molimm.2007.09.020  0.187
2019 Jones BG, Penkert RR, Surman SL, Sealy RE, Pelletier S, Xu B, Neale G, Maul RW, Gearhart PJ, Hurwitz JL. Matters of life and death: How estrogen and estrogen receptor binding to the immunoglobulin heavy chain locus may influence outcomes of infection, allergy, and autoimmune disease. Cellular Immunology. 346: 103996. PMID 31703914 DOI: 10.1016/J.Cellimm.2019.103996  0.185
2007 Gearhart PJ. Generation of immunoglobulin variable gene diversity. Immunology Today. 3: 107-12. PMID 25291455 DOI: 10.1016/S0167-5699(82)80026-1  0.173
2023 Martin OA, Thomas M, Marquet M, Bruzeau C, Garot A, Brousse M, Bender S, Carrion C, Choi JE, Vuong BQ, Gearhart PJ, Maul RW, Le Noir S, Pinaud E. The IgH -MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation. Frontiers in Immunology. 14: 1030813. PMID 36865553 DOI: 10.3389/fimmu.2023.1030813  0.164
2004 Martomo SA, Yang WW, Gearhart PJ. A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination. The Journal of Experimental Medicine. 200: 61-8. PMID 15238605 DOI: 10.1084/jem.20040691  0.159
2000 Duncan MD, Tihan T, Donovan DM, Phung QH, Rowley DL, Harmon JW, Gearhart PJ, Duncan KL. Esophagogastric adenocarcinoma in an E1A/E1B transgenic model involves p53 disruption. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 4: 290-7. PMID 10769092 DOI: 10.1016/S1091-255X(00)80078-5  0.158
2011 Cole LE, Mann BJ, Shirey KA, Richard K, Yang Y, Gearhart PJ, Chesko KL, Viscardi RM, Vogel SN. Role of TLR signaling in Francisella tularensis-LPS-induced, antibody-mediated protection against Francisella tularensis challenge. Journal of Leukocyte Biology. 90: 787-97. PMID 21750122 DOI: 10.1189/Jlb.0111014  0.147
2006 Martomo SA, Gearhart PJ. Somatic hypermutation: subverted DNA repair. Current Opinion in Immunology. 18: 243-8. PMID 16616477 DOI: 10.1016/j.coi.2006.03.007  0.14
2007 Gearhart PM, Steficek BA, Peteresen-Jones SM. Hemangiosarcoma and squamous cell carcinoma in the third eyelid of a horse. Veterinary Ophthalmology. 10: 121-6. PMID 17324168 DOI: 10.1111/j.1463-5224.2007.00510.x  0.134
1997 Winter DB, Gearhart PJ. Somatic hypermutation: Another piece in the hypermutation puzzle. Current Biology : Cb. 5: 1345-6. PMID 8749380 DOI: 10.1016/S0960-9822(95)00265-X  0.124
2008 Gearhart PJ. Response to "Mutation frequency vs. mutation patterns: a comparison of the results in spleen and Peyer's patches" Dna Repair. 7: 1411-1412. PMID 19727317 DOI: 10.1016/j.dnarep.2008.06.001  0.122
2020 Klein SL, Gearhart PJ. Commentary for the 'VSI: Aging and sex in immunity'. Cellular Immunology. 104037. PMID 31992440 DOI: 10.1016/j.cellimm.2019.104037  0.089
2004 Gearhart PJ. The birth of molecular immunology. Journal of Immunology (Baltimore, Md. : 1950). 173: 4259. PMID 15383552  0.086
2001 Gearhart PJ, Zeng X. Response 2 to 'Smaller role for pol η?' Nature Immunology. 2: 984-984. DOI: 10.1038/ni1101-984  0.075
1998 Tchorzewski MT, Duncan MD, Nass P, Qureshi FG, Gearhart PJ, Winchurch R, Harmon JW. Characterization of an aFGF gene expression vector with therapeutic potential. The Journal of Surgical Research. 77: 99-103. PMID 9733594 DOI: 10.1006/jsre.1998.5351  0.074
2003 Montiani-Ferreira F, Petersen-Jones S, Cassotis N, Ramsey DT, Gearhart P, Cardoso F. Early postnatal development of central corneal thickness in dogs. Veterinary Ophthalmology. 6: 19-22. PMID 12641838 DOI: 10.1046/J.1463-5224.2003.00196.X  0.074
1988 LAWLER AM, GEARHART PJ. The Initial Repertoire of VkRearrangements Is Distributed over Many Subfamilies Annals of the New York Academy of Sciences. 546: 251-252. DOI: 10.1111/j.1749-6632.1988.tb21657.x  0.066
1998 Winter DB, Sattar N, Gearhart PJ. The role of promoter-intron interactions in directing hypermutation. Current Topics in Microbiology and Immunology. 229: 1-10. PMID 9479843 DOI: 10.1007/978-3-642-71984-4_1  0.065
2016 Gmeiner WH, Gearhart PJ, Pommier Y, Nakamura J. F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death. Future Oncology (London, England). PMID 27333295 DOI: 10.2217/Fon-2016-0127  0.062
1979 Pickering LK, Gearhart P. Effect of time and concentration upon interaction between gentamicin, tobramycin, netilmicin, or amikacin and carbenicillin or ticarcillin Antimicrobial Agents and Chemotherapy. 15: 592-596. PMID 464591 DOI: 10.1128/AAC.15.4.592  0.042
2010 Gearhart PM, Gearhart C, Thompson DA, Petersen-Jones SM. Improvement of visual performance with intravitreal administration of 9-cis-retinal in Rpe65-mutant dogs. Archives of Ophthalmology (Chicago, Ill. : 1960). 128: 1442-8. PMID 20837787 DOI: 10.1001/archophthalmol.2010.210  0.03
2008 Gearhart PM, Gearhart CC, Petersen-Jones SM. A novel method for objective vision testing in canine models of inherited retinal disease. Investigative Ophthalmology & Visual Science. 49: 3568-76. PMID 18660425 DOI: 10.1167/iovs.07-0625  0.02
2009 Gearhart PJ, Lindahl T, Neuberger MS. Preface. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 364: 561-2. PMID 19008190 DOI: 10.1098/rstb.2008.0236  0.01
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