Raymond J. Pickles - Publications

Affiliations: 
Microbiology & Immunology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Microbiology Biology, Virology Biology

37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Liesman RM, Buchholz UJ, Luongo CL, Yang L, Proia AD, DeVincenzo JP, Collins PL, Pickles RJ. RSV-encoded NS2 promotes epithelial cell shedding and distal airway obstruction. The Journal of Clinical Investigation. 124: 2219-33. PMID 24713657 DOI: 10.1172/JCI72948  0.36
2012 Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, Sallenave JM, Pickles RJ, Boucher RC. Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs Proceedings of the National Academy of Sciences of the United States of America. 109: 16528-16533. PMID 23012413 DOI: 10.1073/pnas.1206552109  0.36
2012 Schaap-Nutt A, Liesman R, Bartlett EJ, Scull MA, Collins PL, Pickles RJ, Schmidt AC. Human parainfluenza virus serotypes differ in their kinetics of replication and cytokine secretion in human tracheobronchial airway epithelium. Virology. 433: 320-8. PMID 22959894 DOI: 10.1016/j.virol.2012.08.027  0.36
2011 Zhang L, Collins PL, Lamb RA, Pickles RJ. Comparison of differing cytopathic effects in human airway epithelium of parainfluenza virus 5 (W3A), parainfluenza virus type 3, and respiratory syncytial virus. Virology. 421: 67-77. PMID 21986028 DOI: 10.1016/j.virol.2011.08.020  0.36
2011 Li W, Zhang L, Wu Z, Pickles RJ, Samulski RJ. AAV-6 mediated efficient transduction of mouse lower airways. Virology. 417: 327-33. PMID 21752418 DOI: 10.1016/j.virol.2011.06.009  0.36
2011 Allen IC, Moore CB, Schneider M, Lei Y, Davis BK, Scull MA, Gris D, Roney KE, Zimmermann AG, Bowzard JB, Ranjan P, Monroe KM, Pickles RJ, Sambhara S, Ting JP. NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways. Immunity. 34: 854-65. PMID 21703540 DOI: 10.1016/j.immuni.2011.03.026  0.36
2011 Johnson JS, Gentzsch M, Zhang L, Ribeiro CM, Kantor B, Kafri T, Pickles RJ, Samulski RJ. AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis. Plos Pathogens. 7: e1002053. PMID 21625534 DOI: 10.1371/journal.ppat.1002053  0.36
2010 Zhang L, Limberis MP, Thompson C, Antunes MB, Luongo C, Wilson JM, Collins PL, Pickles RJ. α-Fetoprotein gene delivery to the nasal epithelium of nonhuman primates by human parainfluenza viral vectors. Human Gene Therapy. 21: 1657-64. PMID 20735256 DOI: 10.1089/hum.2010.065  0.36
2010 Kwilas AR, Yednak MA, Zhang L, Liesman R, Collins PL, Pickles RJ, Peeples ME. Respiratory syncytial virus engineered to express the cystic fibrosis transmembrane conductance regulator corrects the bioelectric phenotype of human cystic fibrosis airway epithelium in vitro. Journal of Virology. 84: 7770-81. PMID 20504917 DOI: 10.1128/JVI.00346-10  0.36
2010 Heiniger RW, Winther-Larsen HC, Pickles RJ, Koomey M, Wolfgang MC. Infection of human mucosal tissue by Pseudomonas aeruginosa requires sequential and mutually dependent virulence factors and a novel pilus-associated adhesin. Cellular Microbiology. 12: 1158-73. PMID 20331639 DOI: 10.1111/j.1462-5822.2010.01461.x  0.36
2010 Eby JC, Ciesla WP, Hamman W, Donato GM, Pickles RJ, Hewlett EL, Lencer WI. Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells. The Journal of Biological Chemistry. 285: 10662-70. PMID 20139088 DOI: 10.1074/jbc.M109.089219  0.36
2010 Schaap-Nutt A, Scull MA, Schmidt AC, Murphy BR, Pickles RJ. Growth restriction of an experimental live attenuated human parainfluenza virus type 2 vaccine in human ciliated airway epithelium in vitro parallels attenuation in African green monkeys. Vaccine. 28: 2788-98. PMID 20139039 DOI: 10.1016/j.vaccine.2010.01.050  0.36
2010 Schaap-Nutt A, D'Angelo C, Scull MA, Amaro-Carambot E, Nishio M, Pickles RJ, Collins PL, Murphy BR, Schmidt AC. Human parainfluenza virus type 2 V protein inhibits interferon production and signaling and is required for replication in non-human primates. Virology. 397: 285-98. PMID 19969320 DOI: 10.1016/j.virol.2009.11.018  0.36
2009 Ayora-Talavera G, Shelton H, Scull MA, Ren J, Jones IM, Pickles RJ, Barclay WS. Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium. Plos One. 4: e7836. PMID 19924306 DOI: 10.1371/journal.pone.0007836  0.36
2009 Kwilas S, Liesman RM, Zhang L, Walsh E, Pickles RJ, Peeples ME. Respiratory syncytial virus grown in Vero cells contains a truncated attachment protein that alters its infectivity and dependence on glycosaminoglycans. Journal of Virology. 83: 10710-8. PMID 19656891 DOI: 10.1128/JVI.00986-09  0.36
2009 Zhang L, Button B, Gabriel SE, Burkett S, Yan Y, Skiadopoulos MH, Dang YL, Vogel LN, McKay T, Mengos A, Boucher RC, Collins PL, Pickles RJ. CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium. Plos Biology. 7: e1000155. PMID 19621064 DOI: 10.1371/journal.pbio.1000155  0.36
2009 Li W, Zhang L, Johnson JS, Zhijian W, Grieger JC, Ping-Jie X, Drouin LM, Agbandje-McKenna M, Pickles RJ, Samulski RJ. Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2067-77. PMID 19603002 DOI: 10.1038/mt.2009.155  0.36
2009 Scull MA, Gillim-Ross L, Santos C, Roberts KL, Bordonali E, Subbarao K, Barclay WS, Pickles RJ. Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways. Plos Pathogens. 5: e1000424. PMID 19436701 DOI: 10.1371/journal.ppat.1000424  0.36
2009 Lei Y, Moore CB, Liesman RM, O'Connor BP, Bergstralh DT, Chen ZJ, Pickles RJ, Ting JP. MAVS-mediated apoptosis and its inhibition by viral proteins. Plos One. 4: e5466. PMID 19404494 DOI: 10.1371/journal.pone.0005466  0.36
2009 Allen IC, Scull MA, Moore CB, Holl EK, McElvania-TeKippe E, Taxman DJ, Guthrie EH, Pickles RJ, Ting JP. The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity. 30: 556-65. PMID 19362020 DOI: 10.1016/j.immuni.2009.02.005  0.36
2009 Limberis MP, Vandenberghe LH, Zhang L, Pickles RJ, Wilson JM. Transduction efficiencies of novel AAV vectors in mouse airway epithelium in vivo and human ciliated airway epithelium in vitro. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 294-301. PMID 19066597 DOI: 10.1038/mt.2008.261  0.36
2009 Bukreyev A, Marzi A, Feldmann F, Zhang L, Yang L, Ward JM, Dorward DW, Pickles RJ, Murphy BR, Feldmann H, Collins PL. Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge. Virology. 383: 348-61. PMID 19010509 DOI: 10.1016/j.virol.2008.09.030  0.36
2008 Becker MM, Graham RL, Donaldson EF, Rockx B, Sims AC, Sheahan T, Pickles RJ, Corti D, Johnston RE, Baric RS, Denison MR. Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 19944-9. PMID 19036930 DOI: 10.1073/pnas.0808116105  0.36
2008 Donaldson EF, Yount B, Sims AC, Burkett S, Pickles RJ, Baric RS. Systematic assembly of a full-length infectious clone of human coronavirus NL63. Journal of Virology. 82: 11948-57. PMID 18818320 DOI: 10.1128/JVI.01804-08  0.36
2008 Bartlett EJ, Cruz AM, Esker J, Castaño A, Schomacker H, Surman SR, Hennessey M, Boonyaratanakornkit J, Pickles RJ, Collins PL, Murphy BR, Schmidt AC. Human parainfluenza virus type 1 C proteins are nonessential proteins that inhibit the host interferon and apoptotic responses and are required for efficient replication in nonhuman primates. Journal of Virology. 82: 8965-77. PMID 18614629 DOI: 10.1128/JVI.00853-08  0.36
2008 Bartlett EJ, Hennessey M, Skiadopoulos MH, Schmidt AC, Collins PL, Murphy BR, Pickles RJ. Role of interferon in the replication of human parainfluenza virus type 1 wild type and mutant viruses in human ciliated airway epithelium. Journal of Virology. 82: 8059-70. PMID 18524813 DOI: 10.1128/JVI.02263-07  0.36
2008 Sims AC, Burkett SE, Yount B, Pickles RJ. SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium. Virus Research. 133: 33-44. PMID 17451829 DOI: 10.1016/j.virusres.2007.03.013  0.36
2007 Chapman J, Abbott E, Alber DG, Baxter RC, Bithell SK, Henderson EA, Carter MC, Chambers P, Chubb A, Cockerill GS, Collins PL, Dowdell VC, Keegan SJ, Kelsey RD, Lockyer MJ, ... ... Pickles RJ, et al. RSV604, a novel inhibitor of respiratory syncytial virus replication. Antimicrobial Agents and Chemotherapy. 51: 3346-53. PMID 17576833 DOI: 10.1128/AAC.00211-07  0.36
2007 Hall JD, Craven RR, Fuller JR, Pickles RJ, Kawula TH. Francisella tularensis replicates within alveolar type II epithelial cells in vitro and in vivo following inhalation. Infection and Immunity. 75: 1034-9. PMID 17088343 DOI: 10.1128/IAI.01254-06  0.36
2006 Sims AC, Yount B, Burkett SE, Baric RS, Pickles RJ. SARS CoV replication and pathogenesis in human airway epithelial cultures. Advances in Experimental Medicine and Biology. 581: 535-8. PMID 17037593 DOI: 10.1007/978-0-387-33012-9_97  0.36
2006 Thompson CI, Barclay WS, Zambon MC, Pickles RJ. Infection of human airway epithelium by human and avian strains of influenza a virus. Journal of Virology. 80: 8060-8. PMID 16873262 DOI: 10.1128/JVI.00384-06  0.36
2005 Sims AC, Baric RS, Yount B, Burkett SE, Collins PL, Pickles RJ. Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs. Journal of Virology. 79: 15511-24. PMID 16306622 DOI: 10.1128/JVI.79.24.15511-15524.2005  0.36
2005 Tarran R, Button B, Picher M, Paradiso AM, Ribeiro CM, Lazarowski ER, Zhang L, Collins PL, Pickles RJ, Fredberg JJ, Boucher RC. Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections. The Journal of Biological Chemistry. 280: 35751-9. PMID 16087672 DOI: 10.1074/jbc.M505832200  0.36
2005 Zhang L, Bukreyev A, Thompson CI, Watson B, Peeples ME, Collins PL, Pickles RJ. Infection of ciliated cells by human parainfluenza virus type 3 in an in vitro model of human airway epithelium. Journal of Virology. 79: 1113-24. PMID 15613339 DOI: 10.1128/JVI.79.2.1113-1124.2005  0.36
2004 Stonebraker JR, Wagner D, Lefensty RW, Burns K, Gendler SJ, Bergelson JM, Boucher RC, O'Neal WK, Pickles RJ. Glycocalyx restricts adenoviral vector access to apical receptors expressed on respiratory epithelium in vitro and in vivo: role for tethered mucins as barriers to lumenal infection. Journal of Virology. 78: 13755-68. PMID 15564484 DOI: 10.1128/JVI.78.24.13755-13768.2004  0.36
2004 Mellow TE, Murphy PC, Carson JL, Noah TL, Zhang L, Pickles RJ. The effect of respiratory synctial virus on chemokine release by differentiated airway epithelium. Experimental Lung Research. 30: 43-57. PMID 14967603  0.36
2002 Zhang L, Peeples ME, Boucher RC, Collins PL, Pickles RJ. Respiratory syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious cytopathology. Journal of Virology. 76: 5654-66. PMID 11991994 DOI: 10.1128/JVI.76.11.5654-5666.2002  0.36
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