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Timothy W. Hand, Ph.D. - Publications

Affiliations: 
2009 Yale University, New Haven, CT 
Area:
Immunology, Microbiology Biology
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Torow N, Li R, Hitch TCA, Mingels C, Al Bounny S, van Best N, Stange EL, Simons B, Maié T, Rüttger L, Gubbi NMKP, Abbott DA, Benabid A, Gadermayr M, Runge S, ... ... Hand TW, et al. M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer's patch. Immunity. PMID 37130522 DOI: 10.1016/j.immuni.2023.04.002  0.358
2022 Wu X, Khatun A, Kasmani MY, Chen Y, Zheng S, Atkinson S, Nguyen C, Burns R, Taparowsky EJ, Salzman NH, Hand TW, Cui W. Group 3 innate lymphoid cells require BATF to regulate gut homeostasis in mice. The Journal of Experimental Medicine. 219. PMID 36048018 DOI: 10.1084/jem.20211861  0.355
2022 Overacre-Delgoffe AE, Hand TW. Regulation of tissue-resident memory T cells by the Microbiota. Mucosal Immunology. PMID 35194180 DOI: 10.1038/s41385-022-00491-1  0.476
2021 Overacre-Delgoffe AE, Bumgarner HJ, Cillo AR, Burr AHP, Tometich JT, Bhattacharjee A, Bruno TC, Vignali DAA, Hand TW. Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer. Immunity. 54: 2812-2824.e4. PMID 34861182 DOI: 10.1016/j.immuni.2021.11.003  0.376
2021 Bhattacharjee A, Burr AHP, Overacre-Delgoffe AE, Tometich JT, Yang D, Huckestein BR, Linehan JL, Spencer SP, Hall JA, Harrison OJ, Morais da Fonseca D, Norton EB, Belkaid Y, Hand TW. Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+ T cell responses and impair oral vaccine efficacy. Immunity. PMID 34348118 DOI: 10.1016/j.immuni.2021.07.005  0.406
2021 Watson MJ, Vignali PDA, Mullett SJ, Overacre-Delgoffe AE, Peralta RM, Grebinoski S, Menk AV, Rittenhouse NL, DePeaux K, Whetstone RD, Vignali DAA, Hand TW, Poholek AC, Morrison BM, Rothstein JD, et al. Metabolic support of tumour-infiltrating regulatory T cells by lactic acid. Nature. PMID 33589820 DOI: 10.1038/s41586-020-03045-2  0.397
2020 Burr AHP, Bhattacharjee A, Hand TW. Nutritional Modulation of the Microbiome and Immune Response. Journal of Immunology (Baltimore, Md. : 1950). 205: 1479-1487. PMID 32900885 DOI: 10.4049/Jimmunol.2000419  0.313
2020 Hand TW. All Bacteroides Are Equal but Some Are More Equal than Others For the Induction of IgA. Cell Host & Microbe. 27: 319-321. PMID 32164843 DOI: 10.1016/J.Chom.2020.02.011  0.313
2020 Overacre-Delgoffe A, Bumgarner H, Hand T. Abstract IA03: Control over colorectal tumor growth via bacteria-specific T-cell activation of the local immune response Cancer Research. 80. DOI: 10.1158/1538-7445.Mvc2020-Ia03  0.508
2020 Watson M, Vignali P, Mullet S, Overacre-Delgoffe A, Peralta R, Grebinoski S, Menk A, Rittenhouse N, DePeaux K, Whetstone R, Vignali D, Hand T, Poholek A, Morrison B, Rothstein J, et al. 517 Regulatory T cell functional identity is sustained by a glucose:lactate axis that is exploited in the tumor microenvironment Journal For Immunotherapy of Cancer. 8: A553-A553. DOI: 10.1136/jitc-2020-sitc2020.0517  0.336
2019 Castillo-Dela Cruz P, Wanek AG, Kumar P, An X, Elsegeiny W, Horne W, Fitch A, Burr AHP, Gopalakrishna KP, Chen K, Methé BA, Canna SW, Hand TW, Kolls JK. Intestinal IL-17R Signaling Constrains IL-18-Driven Liver Inflammation by the Regulation of Microbiome-Derived Products. Cell Reports. 29: 2270-2283.e7. PMID 31747600 DOI: 10.1016/J.Celrep.2019.10.042  0.331
2019 Majumder S, Amatya N, Revu S, Jawale CV, Wu D, Rittenhouse N, Menk A, Kupul S, Du F, Raphael I, Bhattacharjee A, Siebenlist U, Hand TW, Delgoffe GM, Poholek AC, et al. IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival. Nature Immunology. PMID 30962593 DOI: 10.1038/S41590-019-0367-4  0.462
2018 Bhattacharjee A, Hand TW. Role of nutrition, infection, and the microbiota in the efficacy of oral vaccines. Clinical Science (London, England : 1979). 132: 1169-1177. PMID 29925624 DOI: 10.1042/Cs20171106  0.36
2018 Chiaranunt P, Tometich JT, Ji J, Hand TW. T Cell Proliferation and Colitis Are Initiated by Defined Intestinal Microbes. Journal of Immunology (Baltimore, Md. : 1950). PMID 29777027 DOI: 10.4049/Jimmunol.1800236  0.521
2018 Castillo PAC, Hand TW. A Little Fiber Goes a Long Way. Immunity. 48: 844-846. PMID 29768170 DOI: 10.1016/J.Immuni.2018.05.001  0.388
2016 Hand TW. The Role of the Microbiota in Shaping Infectious Immunity. Trends in Immunology. PMID 27616558 DOI: 10.1016/J.It.2016.08.007  0.327
2016 Edwards JP, Hand TW, da Fonseca DM, Glass DD, Belkaid Y, Shevach EM. The GARP/Latent TGF-β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance. European Journal of Immunology. PMID 27062243 DOI: 10.1002/Eji.201546204  0.368
2015 Hand TW. Interleukin-18: The Bouncer at the Mucosal Bar. Cell. 163: 1310-2. PMID 26638066 DOI: 10.1016/J.Cell.2015.11.041  0.314
2015 Fonseca DM, Hand TW, Han SJ, Gerner MY, Glatman Zaretsky A, Byrd AL, Harrison OJ, Ortiz AM, Quinones M, Trinchieri G, Brenchley JM, Brodsky IE, Germain RN, Randolph GJ, Belkaid Y. Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity. Cell. 163: 354-66. PMID 26451485 DOI: 10.1016/J.Cell.2015.08.030  0.35
2015 Askenase MH, Han SJ, Byrd AL, Morais da Fonseca D, Bouladoux N, Wilhelm C, Konkel JE, Hand TW, Lacerda-Queiroz N, Su XZ, Trinchieri G, Grainger JR, Belkaid Y. Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection. Immunity. 42: 1130-42. PMID 26070484 DOI: 10.1016/J.Immuni.2015.05.011  0.358
2014 Peters NC, Pagán AJ, Lawyer PG, Hand TW, Henrique Roma E, Stamper LW, Romano A, Sacks DL. Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection. Plos Pathogens. 10: e1004538. PMID 25473946 DOI: 10.1371/Journal.Ppat.1004538  0.627
2014 Bonelli M, Shih HY, Hirahara K, Singelton K, Laurence A, Poholek A, Hand T, Mikami Y, Vahedi G, Kanno Y, O'Shea JJ. Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes. Current Topics in Microbiology and Immunology. 381: 279-326. PMID 24831346 DOI: 10.1007/82_2014_371  0.518
2014 Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell. 157: 121-41. PMID 24679531 DOI: 10.1016/J.Cell.2014.03.011  0.325
2013 Molloy MJ, Grainger JR, Bouladoux N, Hand TW, Koo LY, Naik S, Quinones M, Dzutsev AK, Gao JL, Trinchieri G, Murphy PM, Belkaid Y. Intraluminal containment of commensal outgrowth in the gut during infection-induced dysbiosis. Cell Host & Microbe. 14: 318-28. PMID 24034617 DOI: 10.1016/J.Chom.2013.08.003  0.327
2013 Belkaid Y, Bouladoux N, Hand TW. Effector and memory T cell responses to commensal bacteria. Trends in Immunology. 34: 299-306. PMID 23643444 DOI: 10.1016/J.It.2013.03.003  0.468
2013 Vahedi G, C Poholek A, Hand TW, Laurence A, Kanno Y, O'Shea JJ, Hirahara K. Helper T-cell identity and evolution of differential transcriptomes and epigenomes. Immunological Reviews. 252: 24-40. PMID 23405893 DOI: 10.1111/Imr.12037  0.523
2012 Hand TW, Dos Santos LM, Bouladoux N, Molloy MJ, Pagán AJ, Pepper M, Maynard CL, Elson CO, Belkaid Y. Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses. Science (New York, N.Y.). 337: 1553-6. PMID 22923434 DOI: 10.1126/Science.1220961  0.532
2011 Joshi NS, Cui W, Dominguez CX, Chen JH, Hand TW, Kaech SM. Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 187: 4068-76. PMID 21930973 DOI: 10.4049/Jimmunol.1002145  0.659
2011 Hall JA, Cannons JL, Grainger JR, Dos Santos LM, Hand TW, Naik S, Wohlfert EA, Chou DB, Oldenhove G, Robinson M, Grigg ME, Kastenmayer R, Schwartzberg PL, Belkaid Y. Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha. Immunity. 34: 435-47. PMID 21419664 DOI: 10.1016/j.immuni.2011.03.003  0.429
2010 Hand TW, Cui W, Jung YW, Sefik E, Joshi NS, Chandele A, Liu Y, Kaech SM. Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. Proceedings of the National Academy of Sciences of the United States of America. 107: 16601-6. PMID 20823247 DOI: 10.1073/Pnas.1003457107  0.683
2010 Hand T, Belkaid Y. Microbial control of regulatory and effector T cell responses in the gut. Current Opinion in Immunology. 22: 63-72. PMID 20171861 DOI: 10.1016/J.Coi.2010.01.008  0.396
2010 Rescigno M, Iliev ID, Belkaid Y, Hall J, Hand T, santos LD, Grainger J, Fagarasan S, Powrie F, Buonocore S, Ahern P, Maloy K, Schiering C, Artis D, Blumberg R. Mucosal immunity (SY2-3) Chairpersons: Sidonia Fagarasan, Fiona Powrie International Immunology. 22. DOI: 10.1093/Intimm/Dxq283  0.301
2009 Hand TW, Kaech SM. Intrinsic and extrinsic control of effector T cell survival and memory T cell development. Immunologic Research. 45: 46-61. PMID 18629449 DOI: 10.1007/S12026-008-8027-Z  0.67
2009 Hand TW, Kaech SM. Decreasing the TORC on memory CD8 T‐cell formation Immunology & Cell Biology. 87: 571-573. DOI: 10.1038/Icb.2009.72  0.597
2007 Hand TW, Morre M, Kaech SM. Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection. Proceedings of the National Academy of Sciences of the United States of America. 104: 11730-5. PMID 17609371 DOI: 10.1073/Pnas.0705007104  0.664
2006 Obhrai JS, Oberbarnscheidt MH, Hand TW, Diggs L, Chalasani G, Lakkis FG. Effector T cell differentiation and memory T cell maintenance outside secondary lymphoid organs. Journal of Immunology (Baltimore, Md. : 1950). 176: 4051-8. PMID 16547240 DOI: 10.4049/Jimmunol.176.7.4051  0.602
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