Rhett Kovall - Publications

Molecular Genetics, Biochemistry, & Microbiology University of Cincinnati, Cincinnati, OH 
Molecular Biology, Biochemistry, General Biophysics

33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kuang Y, Pyo A, Eafergan N, Cain B, Gutzwiller LM, Axelrod O, Gagliani EK, Weirauch MT, Kopan R, Kovall RA, Sprinzak D, Gebelein B. Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor. Plos Genetics. 17: e1009039. PMID 34559800 DOI: 10.1371/journal.pgen.1009039  0.495
2021 Landor SKJ, Santio NM, Eccleshall WB, Paramonov VM, Gagliani EK, Hall D, Jin SB, Dahlström KM, Salminen TA, Rivero-Müller A, Lendahl U, Kovall RA, Koskinen PJ, Sahlgren C. PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion. The Journal of Biological Chemistry. 100593. PMID 33775697 DOI: 10.1016/j.jbc.2021.100593  0.4
2021 Giaimo BD, Gagliani EK, Kovall RA, Borggrefe T. Transcription Factor RBPJ as a Molecular Switch in Regulating the Notch Response. Advances in Experimental Medicine and Biology. 1287: 9-30. PMID 33034023 DOI: 10.1007/978-3-030-55031-8_2  0.514
2020 Kobia FM, Preusse K, Dai Q, Weaver N, Hass MR, Chaturvedi P, Stein SJ, Pear WS, Yuan Z, Kovall RA, Kuang Y, Eafergen N, Sprinzak D, Gebelein B, Brunskill EW, et al. Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation. Plos Biology. 18: e3000850. PMID 33017398 DOI: 10.1371/journal.pbio.3000850  0.474
2020 Kuang Y, Golan O, Preusse K, Cain B, Christensen CJ, Salomone J, Campbell I, Okwubido-Williams FV, Hass MR, Yuan Z, Eafergan N, Moberg KH, Kovall RA, Kopan R, Sprinzak D, et al. Enhancer architecture sensitizes cell-specific responses to gene dose via a bind and discard mechanism. Elife. 9. PMID 32297857 DOI: 10.7554/Elife.53659  0.49
2019 Yuan Z, VanderWielen BD, Giaimo BD, Pan L, Collins CE, Turkiewicz A, Hein K, Oswald F, Borggrefe T, Kovall RA. Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site. Cell Reports. 26: 845-854.e6. PMID 30673607 DOI: 10.1016/j.celrep.2018.12.097  0.537
2018 Oswald F, Kovall RA. CSL-Associated Corepressor and Coactivator Complexes. Advances in Experimental Medicine and Biology. 1066: 279-295. PMID 30030832 DOI: 10.1007/978-3-319-89512-3_14  0.55
2018 Miesfeld JB, Moon MS, Riesenberg AN, Contreras AN, Kovall RA, Brown NL. Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina. Scientific Reports. 8: 10195. PMID 29977079 DOI: 10.1038/S41598-018-28420-Y  0.77
2018 Gomez-Lamarca MJ, Falo-Sanjuan J, Stojnic R, Abdul Rehman S, Muresan L, Jones ML, Pillidge Z, Cerda-Moya G, Yuan Z, Baloul S, Valenti P, Bystricky K, Payre F, O'Holleran K, Kovall R, et al. Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics. Developmental Cell. PMID 29478922 DOI: 10.1016/J.Devcel.2018.01.020  0.477
2017 Xu T, Park SS, Giaimo BD, Hall D, Ferrante F, Ho DM, Hori K, Anhezini L, Ertl I, Bartkuhn M, Zhang H, Milon E, Ha K, Conlon KP, Kuick R, ... ... Kovall RA, et al. RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1. The Embo Journal. PMID 29030483 DOI: 10.15252/Embj.201796525  0.5
2017 Nagel AC, Auer JS, Schulz A, Pfannstiel J, Yuan Z, Collins CE, Kovall RA, Preiss A. Phosphorylation of Suppressor of Hairless impedes its DNA-binding activity. Scientific Reports. 7: 11820. PMID 28928428 DOI: 10.1038/s41598-017-11952-0  0.465
2017 Tabaja N, Yuan Z, Oswald F, Kovall RA. Structure-function analysis of RBPJ-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes. The Journal of Biological Chemistry. PMID 28487372 DOI: 10.1074/jbc.M117.791707  0.54
2017 Kovall RA, Gebelein B, Sprinzak D, Kopan R. The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force. Developmental Cell. 41: 228-241. PMID 28486129 DOI: 10.1016/j.devcel.2017.04.001  0.388
2016 Yuan Z, Praxenthaler H, Tabaja N, Torella R, Preiss A, Maier D, Kovall RA. Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster. Plos Biology. 14: e1002509. PMID 27404588 DOI: 10.1371/journal.pbio.1002509  0.465
2016 Oswald F, Rodriguez P, Giaimo BD, Antonello ZA, Mira L, Mittler G, Thiel VN, Collins KJ, Tabaja N, Cizelsky W, Rothe M, Kühl SJ, Kühl M, Ferrante F, Hein K, ... Kovall RA, et al. A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes. Nucleic Acids Research. PMID 26912830 DOI: 10.1093/nar/gkw105  0.357
2015 Contreras AN, Yuan Z, Kovall RA. Thermodynamic binding analysis of Notch transcription complexes from Drosophila melanogaster. Protein Science : a Publication of the Protein Society. 24: 812-22. PMID 25650119 DOI: 10.1002/Pro.2652  0.789
2014 Torella R, Li J, Kinrade E, Cerda-Moya G, Contreras AN, Foy R, Stojnic R, Glen RC, Kovall RA, Adryan B, Bray SJ. A combination of computational and experimental approaches identifies DNA sequence constraints associated with target site binding specificity of the transcription factor CSL. Nucleic Acids Research. 42: 10550-63. PMID 25114055 DOI: 10.1093/Nar/Gku730  0.76
2014 Collins KJ, Yuan Z, Kovall RA. Structure and function of the CSL-KyoT2 corepressor complex: A negative regulator of Notch signaling Structure. 22: 70-81. PMID 24290140 DOI: 10.1016/j.str.2013.10.010  0.539
2013 Greenwald I, Kovall R. Notch signaling: genetics and structure. Wormbook : the Online Review of C. Elegans Biology. 1-28. PMID 23355521 DOI: 10.1895/Wormbook.1.10.2  0.402
2012 Yuan Z, Friedmann DR, VanderWielen BD, Collins KJ, Kovall RA. Characterization of CSL (CBF-1, Su(H), Lag-1) mutants reveals differences in signaling mediated by Notch1 and Notch2. The Journal of Biological Chemistry. 287: 34904-16. PMID 22915591 DOI: 10.1074/Jbc.M112.403287  0.767
2011 Kurth P, Preiss A, Kovall RA, Maier D. Molecular analysis of the notch repressor-complex in Drosophila: characterization of potential hairless binding sites on suppressor of hairless. Plos One. 6: e27986. PMID 22125648 DOI: 10.1371/journal.pone.0027986  0.53
2011 Maier D, Kurth P, Schulz A, Russell A, Yuan Z, Gruber K, Kovall RA, Preiss A. Structural and functional analysis of the repressor complex in the Notch signaling pathway of Drosophila melanogaster. Molecular Biology of the Cell. 22: 3242-52. PMID 21737682 DOI: 10.1091/mbc.E11-05-0420  0.512
2011 VanderWielen BD, Yuan Z, Friedmann DR, Kovall RA. Transcriptional repression in the Notch pathway: thermodynamic characterization of CSL-MINT (Msx2-interacting nuclear target protein) complexes. The Journal of Biological Chemistry. 286: 14892-902. PMID 21372128 DOI: 10.1074/Jbc.M110.181156  0.774
2010 Conrady DG, Flagler MJ, Friedmann DR, Vander Wielen BD, Kovall RA, Weiss AA, Herr AB. Molecular basis of differential B-pentamer stability of Shiga toxins 1 and 2. Plos One. 5: e15153. PMID 21203383 DOI: 10.1371/Journal.Pone.0015153  0.593
2010 Kovall RA, Blacklow SC. Mechanistic insights into Notch receptor signaling from structural and biochemical studies. Current Topics in Developmental Biology. 92: 31-71. PMID 20816392 DOI: 10.1016/S0070-2153(10)92002-4  0.46
2010 Friedmann DR, Kovall RA. Thermodynamic and structural insights into CSL-DNA complexes. Protein Science : a Publication of the Protein Society. 19: 34-46. PMID 19866488 DOI: 10.1002/Pro.280  0.753
2008 Friedmann DR, Wilson JJ, Kovall RA. RAM-induced allostery facilitates assembly of a notch pathway active transcription complex. The Journal of Biological Chemistry. 283: 14781-91. PMID 18381292 DOI: 10.1074/Jbc.M709501200  0.74
2006 Wilson JJ, Kovall RA. Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Cell. 124: 985-96. PMID 16530045 DOI: 10.1016/j.cell.2006.01.035  0.542
2004 Kovall RA, Hendrickson WA. Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA Embo Journal. 23: 3441-3451. PMID 15297877 DOI: 10.1038/Sj.Emboj.7600349  0.67
2003 Min KC, Kovall RA, Hendrickson WA. Crystal structure of human α-tocopherol transfer protein bound to its ligand: Implications for ataxia with vitamin E deficiency Proceedings of the National Academy of Sciences of the United States of America. 100: 14713-14718. PMID 14657365 DOI: 10.1073/Pnas.2136684100  0.437
1999 Kovall RA, Matthews BW. Type II restriction endonucleases: structural, functional and evolutionary relationships. Current Opinion in Chemical Biology. 3: 578-83. PMID 10508668 DOI: 10.1016/S1367-5931(99)00012-5  0.446
1998 Kovall RA, Matthews BW. Structural, functional, and evolutionary relationships between lambda-exonuclease and the type II restriction endonucleases. Proceedings of the National Academy of Sciences of the United States of America. 95: 7893-7. PMID 9653111 DOI: 10.1073/Pnas.95.14.7893  0.452
1997 Kovall R, Matthews BW. Toroidal structure of lambda-exonuclease. Science (New York, N.Y.). 277: 1824-7. PMID 9295273 DOI: 10.1126/Science.277.5333.1824  0.442
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