Achsah D. Keegan - Publications

Affiliations: 
Molecular Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
Immunology, Molecular Biology

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Chapoval SP, Hritzo M, Qi X, Tamagnone L, Golding A, Keegan AD. Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1. Immunohorizons. 3: 71-87. PMID 31236543 DOI: 10.4049/immunohorizons.1800026  0.4
2018 Roberts NB, Alqazzaz A, Hwang JR, Qi X, Keegan AD, Kim AJ, Winkles JA, Woodworth GF. Oxaliplatin disrupts pathological features of glioma cells and associated macrophages independent of apoptosis induction. Journal of Neuro-Oncology. PMID 30132163 DOI: 10.1007/S11060-018-2979-1  0.4
2016 Dasgupta P, Dorsey NJ, Li J, Qi X, Smith EP, Yamaji-Kegan K, Keegan AD. The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation. Science Signaling. 9: ra63. PMID 27330190 DOI: 10.1126/Scisignal.Aad6724  0.68
2016 Song C, Nicholson JD, Clark SM, Li X, Keegan AD, Tonelli LH. Expansion of Brain T cells in Homeostatic Conditions in Lymphopenic Rag2(-/-) Mice. Brain, Behavior, and Immunity. PMID 27013354 DOI: 10.1016/J.Bbi.2016.03.017  0.68
2015 Zhang ZQ, Wang J, Hoy Z, Keegan A, Gigliotti F, Wright T. Neither classical nor alternative macrophage activation is required for Pneumocystis clearance during immune reconstitution inflammatory syndrome. Infection and Immunity. PMID 26371121 DOI: 10.1128/Iai.00763-15  0.68
2015 Palaniyandi S, Liu X, Periasamy S, Ma A, Tang J, Jenkins M, Tuo W, Song W, Keegan AD, Conrad DH, Zhu X. Inhibition of CD23-mediated IgE transcytosis suppresses the initiation and development of allergic airway inflammation. Mucosal Immunology. PMID 25783969 DOI: 10.1038/Mi.2015.16  0.68
2014 Clark SM, Sand J, Francis TC, Nagaraju A, Michael KC, Keegan AD, Kusnecov A, Gould TD, Tonelli LH. Immune status influences fear and anxiety responses in mice after acute stress exposure. Brain, Behavior, and Immunity. 38: 192-201. PMID 24524915 DOI: 10.1016/J.Bbi.2014.02.001  0.68
2013 Dasgupta P, Qi X, Smith EP, Keegan AD. Absence of the common gamma chain (γ(c)), a critical component of the Type I IL-4 receptor, increases the severity of allergic lung inflammation. Plos One. 8: e71344. PMID 23940740 DOI: 10.1371/Journal.Pone.0071344  0.68
2013 Shanks K, Nkyimbeng-Takwi EH, Smith E, Lipsky MM, DeTolla LJ, Scott DW, Keegan AD, Chapoval SP. Neuroimmune semaphorin 4D is necessary for optimal lung allergic inflammation. Molecular Immunology. 56: 480-7. PMID 23911404 DOI: 10.1016/J.Molimm.2013.05.228  0.68
2013 Dorsey NJ, Chapoval SP, Smith EP, Skupsky J, Scott DW, Keegan AD. STAT6 controls the number of regulatory T cells in vivo, thereby regulating allergic lung inflammation. Journal of Immunology (Baltimore, Md. : 1950). 191: 1517-28. PMID 23825312 DOI: 10.4049/Jimmunol.1300486  0.68
2013 Porter HA, Perry A, Kingsley C, Tran NL, Keegan AD. IRS1 is highly expressed in localized breast tumors and regulates the sensitivity of breast cancer cells to chemotherapy, while IRS2 is highly expressed in invasive breast tumors. Cancer Letters. 338: 239-48. PMID 23562473 DOI: 10.1016/J.Canlet.2013.03.030  0.68
2013 Rajaiah R, Perkins DJ, Polumuri SK, Zhao A, Keegan AD, Vogel SN. Dissociation of endotoxin tolerance and differentiation of alternatively activated macrophages. Journal of Immunology (Baltimore, Md. : 1950). 190: 4763-72. PMID 23543762 DOI: 10.4049/Jimmunol.1202407  0.68
2013 Yang Z, Grinchuk V, Urban JF, Bohl J, Sun R, Notari L, Yan S, Ramalingam T, Keegan AD, Wynn TA, Shea-Donohue T, Zhao A. Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity. Plos One. 8: e59441. PMID 23536877 DOI: 10.1371/Journal.Pone.0059441  0.68
2013 Atamas SP, Chapoval SP, Keegan AD. Cytokines in chronic respiratory diseases. F1000 Biology Reports. 5: 3. PMID 23413371 DOI: 10.3410/B5-3  0.32
2013 Chapoval SP, Keegan AD. Neuroimmune semaphorins as potential biomarkers and drug targets for asthma Journal of Molecular Biomarkers & Diagnosis. DOI: 10.4172/2155-9929.S1.017  0.32
2012 Heller NM, Qi X, Gesbert F, Keegan AD. The extracellular and transmembrane domains of the γC and interleukin (IL)-13 receptor α1 chains, not their cytoplasmic domains, dictate the nature of signaling responses to IL-4 and IL-13. The Journal of Biological Chemistry. 287: 31948-61. PMID 22829596 DOI: 10.1074/Jbc.M112.348896  0.4
2012 Heller NM, Gwinn WM, Donnelly RP, Constant SL, Keegan AD. IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro. Plos One. 7: e39673. PMID 22761864 DOI: 10.1371/Journal.Pone.0039673  0.68
2012 Porter HA, Carey GB, Keegan AD. Insulin receptor substrate 1 expression enhances the sensitivity of 32D cells to chemotherapy-induced cell death. Experimental Cell Research. 318: 1745-58. PMID 22652453 DOI: 10.1016/J.Yexcr.2012.04.020  0.68
2012 Nkyimbeng-Takwi EH, Shanks K, Smith E, Iyer A, Lipsky MM, Detolla LJ, Kikutani H, Keegan AD, Chapoval SP. Neuroimmune semaphorin 4A downregulates the severity of allergic response. Mucosal Immunology. 5: 409-19. PMID 22472774 DOI: 10.1038/Mi.2012.18  0.32
2012 Dasgupta P, Keegan AD. Contribution of alternatively activated macrophages to allergic lung inflammation: a tale of mice and men. Journal of Innate Immunity. 4: 478-88. PMID 22440980 DOI: 10.1159/000336025  1
2012 Ford AQ, Dasgupta P, Mikhailenko I, Smith EM, Noben-Trauth N, Keegan AD. Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation. Bmc Immunology. 13: 6. PMID 22292924 DOI: 10.1186/1471-2172-13-6  1
2012 Ganz T, Madera L, Hancock REW, Suzuki T, Yamamoto N, Watanabe M, Takaku H, Chang MO, Cortez-Retamozo V, Etzrodt M, Pittet MJ, Anders H, Weidenbusch M, Gordon S, Fisher EA, ... ... Keegan AD, et al. Contents Vol. 4, 2012 Journal of Innate Immunity. 4. DOI: 10.1159/000341372  1
2011 Dasgupta P, Chapoval SP, Smith EP, Keegan AD. Transfer of in vivo primed transgenic T cells supports allergic lung inflammation and FIZZ1 and Ym1 production in an IL-4Rα and STAT6 dependent manner. Bmc Immunology. 12: 60. PMID 22014099 DOI: 10.1186/1471-2172-12-60  0.68
2011 Prabhakara R, Harro JM, Leid JG, Keegan AD, Prior ML, Shirtliff ME. Suppression of the inflammatory immune response prevents the development of chronic biofilm infection due to methicillin-resistant Staphylococcus aureus. Infection and Immunity. 79: 5010-8. PMID 21947772 DOI: 10.1128/Iai.05571-11  0.68
2011 Yu M, Qi X, Moreno JL, Farber DL, Keegan AD. NF-κB signaling participates in both RANKL- and IL-4-induced macrophage fusion: receptor cross-talk leads to alterations in NF-κB pathways. Journal of Immunology (Baltimore, Md. : 1950). 187: 1797-806. PMID 21734075 DOI: 10.4049/Jimmunol.1002628  0.68
2011 Lai W, Yu M, Huang MN, Okoye F, Keegan AD, Farber DL. Transcriptional control of rapid recall by memory CD4 T cells. Journal of Immunology (Baltimore, Md. : 1950). 187: 133-40. PMID 21642544 DOI: 10.4049/Jimmunol.1002742  0.68
2011 Myneni SR, Settem RP, Connell TD, Keegan AD, Gaffen SL, Sharma A. TLR2 signaling and Th2 responses drive Tannerella forsythia-induced periodontal bone loss. Journal of Immunology (Baltimore, Md. : 1950). 187: 501-9. PMID 21632710 DOI: 10.4049/Jimmunol.1100683  0.68
2011 Smith EP, Shanks K, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP. Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor. Bmc Immunology. 12: 30. PMID 21595947 DOI: 10.1186/1471-2172-12-30  0.68
2011 Mathews JA, Ford J, Norton S, Kang D, Dellinger A, Gibb DR, Ford AQ, Massay H, Kepley CL, Scherle P, Keegan AD, Conrad DH. A potential new target for asthma therapy: a disintegrin and metalloprotease 10 (ADAM10) involvement in murine experimental asthma. Allergy. 66: 1193-200. PMID 21557750 DOI: 10.1111/J.1398-9995.2011.02614.X  0.68
2011 Chapoval SP, Dasgupta P, Smith EP, DeTolla LJ, Lipsky MM, Kelly-Welch AE, Keegan AD. STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease. Journal of Immunology (Baltimore, Md. : 1950). 186: 2571-83. PMID 21242523 DOI: 10.4049/Jimmunol.1002567  0.68
2010 Shirey KA, Pletneva LM, Puche AC, Keegan AD, Prince GA, Blanco JC, Vogel SN. Control of RSV-induced lung injury by alternatively activated macrophages is IL-4R alpha-, TLR4-, and IFN-beta-dependent. Mucosal Immunology. 3: 291-300. PMID 20404812 DOI: 10.1038/Mi.2010.6  0.68
2010 Chapoval S, Dasgupta P, Dorsey NJ, Keegan AD. Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6. Journal of Leukocyte Biology. 87: 1011-8. PMID 20335310 DOI: 10.1189/Jlb.1209772  0.68
2010 Porter HA, Keegan AD. Abstract 4014: Differential expression and activation of IRS1 and IRS2 in breast cancer cell lines Cancer Research. 70: 4014-4014. DOI: 10.1158/1538-7445.Am10-4014  1
2009 Ford AQ, Heller NM, Stephenson L, Boothby MR, Keegan AD. An atopy-associated polymorphism in the ectodomain of the IL-4R(alpha) chain (V50) regulates the persistence of STAT6 phosphorylation. Journal of Immunology (Baltimore, Md. : 1950). 183: 1607-16. PMID 19592641 DOI: 10.4049/jimmunol.0803266  0.32
2009 Chapoval SP, Lee CG, Tang C, Keegan AD, Cohn L, Bottomly K, Elias JA. Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation. Clinical Immunology (Orlando, Fla.). 132: 371-84. PMID 19553159 DOI: 10.1016/J.Clim.2009.05.016  0.68
2008 Heller NM, Qi X, Junttila IS, Shirey KA, Vogel SN, Paul WE, Keegan AD. Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages. Science Signaling. 1: ra17. PMID 19109239 DOI: 10.1126/Scisignal.1164795  0.68
2008 Shirey KA, Cole LE, Keegan AD, Vogel SN. Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanism. Journal of Immunology (Baltimore, Md. : 1950). 181: 4159-67. PMID 18768873 DOI: 10.4049/Jimmunol.181.6.4159  0.68
2008 LaPorte SL, Juo ZS, Vaclavikova J, Colf LA, Qi X, Heller NM, Keegan AD, Garcia KC. Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell. 132: 259-72. PMID 18243101 DOI: 10.1016/j.cell.2007.12.030  0.68
2007 Miller RR, Hicks GE, Shardell MD, Cappola AR, Hawkes WG, Yu-Yahiro JA, Keegan A, Magaziner J. Association of serum vitamin D levels with inflammatory response following hip fracture: the Baltimore Hip Studies. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 62: 1402-6. PMID 18166692 DOI: 10.1093/Gerona/62.12.1402  0.68
2007 Carey GB, Semenova E, Qi X, Keegan AD. IL-4 protects the B-cell lymphoma cell line CH31 from anti-IgM-induced growth arrest and apoptosis: contribution of the PI-3 kinase/AKT pathway. Cell Research. 17: 942-55. PMID 17968425 DOI: 10.1038/Sj.Cr.2007.90  0.68
2007 Moreno JL, Mikhailenko I, Tondravi MM, Keegan AD. IL-4 promotes the formation of multinucleated giant cells from macrophage precursors by a STAT6-dependent, homotypic mechanism: contribution of E-cadherin. Journal of Leukocyte Biology. 82: 1542-53. PMID 17855502 DOI: 10.1189/Jlb.0107058  0.32
2006 Gwinn WM, Damsker JM, Falahati R, Okwumabua I, Kelly-Welch A, Keegan AD, Vanpouille C, Lee JJ, Dent LA, Leitenberg D, Bukrinsky MI, Constant SL. Novel approach to inhibit asthma-mediated lung inflammation using anti-CD147 intervention. Journal of Immunology (Baltimore, Md. : 1950). 177: 4870-9. PMID 16982929 DOI: 10.4049/Jimmunol.177.7.4870  0.68
2005 Kelly-Welch A, Hanson EM, Keegan AD. Interleukin-4 (IL-4) pathway. Science's Stke : Signal Transduction Knowledge Environment. 2005: cm9. PMID 16030287 DOI: 10.1126/Stke.2932005Cm9  0.68
2005 Kelly-Welch A, Hanson EM, Keegan AD. Interleukin-13 (IL-13) pathway. Science's Stke : Signal Transduction Knowledge Environment. 2005: cm8. PMID 16030286 DOI: 10.1126/Stke.2932005Cm8  0.68
2004 Kelly-Welch AE, Melo ME, Smith E, Ford AQ, Haudenschild C, Noben-Trauth N, Keegan AD. Complex role of the IL-4 receptor alpha in a murine model of airway inflammation: expression of the IL-4 receptor alpha on nonlymphoid cells of bone marrow origin contributes to severity of inflammation. Journal of Immunology (Baltimore, Md. : 1950). 172: 4545-55. PMID 15034072 DOI: 10.4049/Jimmunol.172.7.4545  0.32
2003 Roberts AI, Devadas S, Zhang X, Zhang L, Keegan A, Greeneltch K, Solomon J, Wei L, Das J, Sun E, Liu C, Yuan Z, Zhou JN, Shi Y. The Role of Activation-Induced Cell Death in the Differentiation of T-Helper-Cell Subsets Immunologic Research. 28: 285-293. PMID 14713720 DOI: 10.1385/Ir:28:3:285  0.68
2003 Mora AL, Stephenson LM, Enerson B, Youn J, Keegan AD, Boothby M. New programming of IL-4 receptor signal transduction in activated T cells: Stat6 induction and Th2 differentiation mediated by IL-4Ralpha lacking cytoplasmic tyrosines. Journal of Immunology (Baltimore, Md. : 1950). 171: 1891-900. PMID 12902491 DOI: 10.4049/Jimmunol.171.4.1891  0.68
2003 Kelly-Welch AE, Hanson EM, Boothby MR, Keegan AD. Interleukin-4 and interleukin-13 signaling connections maps. Science (New York, N.Y.). 300: 1527-8. PMID 12791978 DOI: 10.1126/science.1085458  0.68
2003 Hanson EM, Dickensheets H, Qu CK, Donnelly RP, Keegan AD. Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome. The Journal of Biological Chemistry. 278: 3903-11. PMID 12459556 DOI: 10.1074/Jbc.M211747200  0.68
2002 Li L, Qi X, Williams M, Shi Y, Keegan AD. Overexpression of insulin receptor substrate-1, but not insulin receptor substrate-2, protects a T cell hybridoma from activation-induced cell death. Journal of Immunology (Baltimore, Md. : 1950). 168: 6215-23. PMID 12055235 DOI: 10.4049/Jimmunol.168.12.6215  0.4
1996 Ryan JJ, McReynolds LJ, Keegan A, Wang LH, Garfein E, Rothman P, Nelms K, Paul WE. Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor Immunity. 4: 123-132. PMID 8624803 DOI: 10.1016/S1074-7613(00)80677-9  0.68
1995 Quelle FW, Shimoda K, Thierfelder W, Fischer C, Kim A, Ruben SM, Cleveland JL, Pierce JH, Keegan AD, Nelms K. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Molecular and Cellular Biology. 15: 3336-43. PMID 7760829 DOI: 10.1128/Mcb.15.6.3336  0.68
1995 Pernis A, Witthuhn B, Keegan AD, Nelms K, Garfein E, Ihle JN, Paul WE, Pierce JH, Rothman P. Interleukin 4 signals through two related pathways. Proceedings of the National Academy of Sciences of the United States of America. 92: 7971-5. PMID 7544011 DOI: 10.1073/Pnas.92.17.7971  0.68
1995 Keegan AD, Johnston JA, Tortolani PJ, Mcreynolds LJ, Kinzer C, O'Shea JJ, Paul WE. Similarities and differences in signal transduction by interleukin 4 and interleukin 13: Analysis of Janus kinase activation Proceedings of the National Academy of Sciences of the United States of America. 92: 7681-7685. PMID 7544000 DOI: 10.1073/Pnas.92.17.7681  0.68
1993 Wang LM, Keegan AD, Li W, Lienhard GE, Pacini S, Gutkind JS, Myers MG, Sun XJ, White MF, Aaronson SA, Paul WE, Pierce JH. Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells Proceedings of the National Academy of Sciences of the United States of America. 90: 4032-4036. PMID 7683417 DOI: 10.1073/Pnas.90.9.4032  0.68
1985 Siliciano RF, Colello RM, Keegan AD, Dintzis RZ, Dintzis HM, Shin HS. Antigen valence determines the binding of nominal antigen to cytolytic T cell clones Journal of Experimental Medicine. 162: 768-773. PMID 2410534 DOI: 10.1084/Jem.162.2.768  0.68
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