Helen I. Zgurskaya - Publications

Department of Chemistry and Biochemistry University of Oklahoma, Norman, OK, United States 
Biochemistry, Microbiology Biology

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Jackson M, Stevens CM, Zhang L, Zgurskaya HI, Niederweis M. Transporters Involved in the Biogenesis and Functionalization of the Mycobacterial Cell Envelope. Chemical Reviews. PMID 33170669 DOI: 10.1021/acs.chemrev.0c00869  0.44
2020 Fabre L, Ntreh AT, Yazidi A, Leus IV, Weeks JW, Bhattacharyya S, Ruickoldt J, Rouiller I, Zgurskaya HI, Sygusch J. A "Drug Sweeping" State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa. Structure (London, England : 1993). PMID 32966762 DOI: 10.1016/j.str.2020.09.001  0.6
2020 Leus IV, Adamiak J, Trinh AN, Smith RD, Smith L, Richardson S, Ernst RK, Zgurskaya HI. Inactivation of AdeABC and AdeIJK efflux pumps elicits specific nonoverlapping transcriptional and phenotypic responses in Acinetobacter baumannii. Molecular Microbiology. PMID 32858760 DOI: 10.1111/mmi.14594  0.6
2020 Mansbach RA, Leus IV, Mehla J, Lopez CA, Walker JK, Rybenkov VV, Hengartner N, Zgurskaya HI, Gnanakaran S. Machine Learning Algorithm Identifies an Antibiotic Vocabulary for Permeating Gram-Negative Bacteria. Journal of Chemical Information and Modeling. PMID 32453589 DOI: 10.1021/acs.jcim.0c00352  0.6
2020 Leus IV, Weeks JW, Bonifay V, Smith L, Richardson S, Zgurskaya HI. Erratum for Leus et al., "Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii". Journal of Bacteriology. 202. PMID 32217668 DOI: 10.1128/JB.00088-20  0.6
2020 Saha P, Sikdar S, Krishnamoorthy G, Zgurskaya HI, Rybenkov VV. Drug permeation against efflux by two transporters. Acs Infectious Diseases. PMID 32039579 DOI: 10.1021/acsinfecdis.9b00510  1
2019 Krishnamoorthy G, Weeks JW, Zhang Z, Chandler C, Xue H, Schweizer HP, Ernst RK, Zgurskaya HI. Efflux pumps of control the permeability barrier of the outer membrane. Antimicrobial Agents and Chemotherapy. PMID 31383661 DOI: 10.1128/AAC.00956-19  1
2019 Belardinelli JM, Stevens CM, Li W, Tan YZ, Jones V, Mancia F, Zgurskaya HI, Jackson M. The MmpL3 interactome reveals a complex crosstalk between cell envelope biosynthesis and cell elongation and division in mycobacteria. Scientific Reports. 9: 10728. PMID 31341202 DOI: 10.1038/s41598-019-47159-8  0.44
2019 Zgurskaya HI, Rybenkov VV. Permeability barriers of Gram-negative pathogens. Annals of the New York Academy of Sciences. PMID 31165502 DOI: 10.1111/nyas.14134  0.6
2019 Li Y, Gardner JJ, Fortney KR, Leus IV, Bonifay V, Zgurskaya HI, Pletnev AA, Zhang S, Zhang ZY, Gribble GW, Spinola SM, Duerfeldt AS. First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 31104993 DOI: 10.1016/j.bmcl.2019.05.003  0.6
2018 Zhao H, Petrushenko ZM, Walker JK, Baudry J, Zgurskaya HI, Rybenkov VV. Small Molecule Condensin Inhibitors. Acs Infectious Diseases. PMID 30346684 DOI: 10.1021/acsinfecdis.8b00222  0.6
2018 Cooper SJ, Krishnamoorthy G, Wolloscheck D, Walker JK, Rybenkov VV, Parks JM, Zgurskaya HI. Molecular Properties that Define the Activities of Antibiotics in Escherichia coli and Pseudomonas aeruginosa. Acs Infectious Diseases. PMID 29756762 DOI: 10.1021/acsinfecdis.8b00036  1
2018 Leus IV, Weeks JW, Bonifay V, Smith L, Richardson S, Zgurskaya HI. Substrate specificities and efflux efficiencies of RND efflux pumps of . Journal of Bacteriology. PMID 29661860 DOI: 10.1128/JB.00049-18  0.6
2018 Zgurskaya HI, Rybenkov VV, Krishnamoorthy G, Leus IV. Trans-envelope multidrug efflux pumps of Gram-negative bacteria and their synergism with the outer membrane barrier. Research in Microbiology. PMID 29454787 DOI: 10.1016/j.resmic.2018.02.002  1
2018 Picard M, Tikhonova EB, Broutin I, Lu S, Verchère A, Zgurskaya HI. Biochemical Reconstitution and Characterization of Multicomponent Drug Efflux Transporters. Methods in Molecular Biology (Clifton, N.J.). 1700: 113-145. PMID 29177829 DOI: 10.1007/978-1-4939-7454-2_8  1
2017 Wolloscheck D, Krishnamoorthy G, Nguyen J, Zgurskaya HI. Kinetic control of quorum sensing in Pseudomonas aeruginosa by multidrug efflux pumps. Acs Infectious Diseases. PMID 29115136 DOI: 10.1021/acsinfecdis.7b00160  1
2017 Krishnamoorthy G, Leus IV, Weeks JW, Wolloscheck D, Rybenkov VV, Zgurskaya HI. Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative Bacteria. Mbio. 8. PMID 29089426 DOI: 10.1128/mBio.01172-17  1
2017 Westfall DA, Krishnamoorthy G, Wolloscheck D, Sarkar R, Zgurskaya HI, Rybenkov VV. Bifurcation kinetics of drug uptake by Gram-negative bacteria. Plos One. 12: e0184671. PMID 28926596 DOI: 10.1371/journal.pone.0184671  1
2017 Haynes KM, Abdali N, Jhawar V, Zgurskaya HI, Parks JM, Green AT, Baudry JY, Rybenkov VV, Smith JC, Walker JK. Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli. Journal of Medicinal Chemistry. PMID 28650638 DOI: 10.1021/acs.jmedchem.7b00453  0.6
2016 Abdali N, Parks JM, Haynes K, Chaney JL, Green AT, Wolloscheck D, Walker JK, Rybenkov VV, Baudry JY, Smith JC, Zgurskaya HI. Reviving antibiotics: efflux pump inhibitors that interact with AcrA, a membrane fusion protein of the AcrAB-TolC multidrug efflux pump. Acs Infectious Diseases. PMID 27768847 DOI: 10.1021/acsinfecdis.6b00167  0.68
2016 Belardinelli JM, Yazidi A, Yang L, Fabre L, Li W, Jacques B, Angala SK, Rouiller I, Zgurskaya HI, Sygusch J, Jackson M. Structure-Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis. Acs Infectious Diseases. 2: 702-713. PMID 27737557 DOI: 10.1021/acsinfecdis.6b00095  1
2016 Krishnamoorthy G, Wolloscheck D, Weeks JW, Croft C, Rybenkov VV, Zgurskaya HI. Breaking the permeability barrier of Escherichia coli by controlled hyperporination of the outer membrane. Antimicrobial Agents and Chemotherapy. PMID 27697764 DOI: 10.1128/AAC.01882-16  1
2016 Ntreh AT, Weeks JW, Nickels LM, Zgurskaya HI. Opening the channel: the two functional interfaces of Pseudomonas aeruginosa OpmH with the triclosan efflux pump TriABC. Journal of Bacteriology. PMID 27645384 DOI: 10.1128/JB.00535-16  0.6
2016 Zhao H, Clevenger A, Ritchey JW, Zgurskaya HI, Rybenkov VV. Pseudomonas aeruginosa condensins support opposite differentiation states. Journal of Bacteriology. PMID 27528506 DOI: 10.1128/JB.00448-16  0.6
2016 Petrushenko ZM, Zhao H, Zgurskaya HI, Rybenkov VV. Novobiocin susceptibility of MukBEF deficient Escherichia coli is combinatorial with efflux and resides in DNA topoisomerases. Antimicrobial Agents and Chemotherapy. PMID 26926630 DOI: 10.1128/AAC.03102-15  1
2015 Weeks JW, Nickels LM, Ntreh AT, Zgurskaya HI. Non-equivalent roles of two periplasmic subunits in the function and assembly of triclosan pump TriABC from Pseudomonas aeruginosa. Molecular Microbiology. 98: 343-56. PMID 26193906 DOI: 10.1111/mmi.13124  0.6
2015 Zgurskaya HI, Weeks JW, Ntreh AT, Nickels LM, Wolloscheck D. Mechanism of coupling drug transport reactions located in two different membranes. Frontiers in Microbiology. 6: 100. PMID 25759685 DOI: 10.3389/fmicb.2015.00100  1
2015 Weeks JW, Nickels LM, Ntreh AT, Zgurskaya HI. Non-equivalent roles of two periplasmic subunits in the function and assembly of triclosan pump TriABC from Pseudomonas aeruginosa Molecular Microbiology. DOI: 10.1111/mmi.13124  1
2014 Yang L, Lu S, Belardinelli J, Huc-Claustre E, Jones V, Jackson M, Zgurskaya HI. RND transporters protect Corynebacterium glutamicum from antibiotics by assembling the outer membrane. Microbiologyopen. 3: 484-96. PMID 24942069 DOI: 10.1002/mbo3.182  1
2013 Lu S, Zgurskaya HI. MacA, a periplasmic membrane fusion protein of the macrolide transporter MacAB-TolC, binds lipopolysaccharide core specifically and with high affinity. Journal of Bacteriology. 195: 4865-72. PMID 23974027 DOI: 10.1128/JB.00756-13  1
2013 Krishnamoorthy G, Tikhonova EB, Dhamdhere G, Zgurskaya HI. On the role of TolC in multidrug efflux: the function and assembly of AcrAB-TolC tolerate significant depletion of intracellular TolC protein. Molecular Microbiology. 87: 982-97. PMID 23331412 DOI: 10.1111/mmi.12143  1
2013 Tikhonova EB, Zgurskaya HI. Assessment of multidrug efflux assemblies by surface plasmon resonance. Methods in Molecular Biology (Clifton, N.J.). 966: 133-55. PMID 23299733 DOI: 10.1007/978-1-62703-245-2_9  0.8
2012 Lu S, Zgurskaya HI. Role of ATP binding and hydrolysis in assembly of MacAB-TolC macrolide transporter. Molecular Microbiology. 86: 1132-43. PMID 23057817 DOI: 10.1111/mmi.12046  1
2012 Sun Z, Tikhonova EB, Zgurskaya HI, Rybenkov VV. Parallel lipoplex folding pathways revealed using magnetic tweezers. Biomacromolecules. 13: 3395-400. PMID 22988939 DOI: 10.1021/bm301155w  1
2012 Yamada Y, Tikhonova EB, Zgurskaya HI. YknWXYZ is an unusual four-component transporter with a role in protection against sporulation-delaying-protein-induced killing of Bacillus subtilis. Journal of Bacteriology. 194: 4386-94. PMID 22707703 DOI: 10.1128/JB.00223-12  0.8
2011 Zgurskaya HI, Krishnamoorthy G, Ntreh A, Lu S. Mechanism and Function of the Outer Membrane Channel TolC in Multidrug Resistance and Physiology of Enterobacteria. Frontiers in Microbiology. 2: 189. PMID 21954395 DOI: 10.3389/fmicb.2011.00189  1
2011 Tikhonova EB, Yamada Y, Zgurskaya HI. Sequential mechanism of assembly of multidrug efflux pump AcrAB-TolC. Chemistry & Biology. 18: 454-63. PMID 21513882 DOI: 10.1016/j.chembiol.2011.02.011  0.8
2010 Dhamdhere G, Krishnamoorthy G, Zgurskaya HI. Interplay between drug efflux and antioxidants in Escherichia coli resistance to antibiotics. Antimicrobial Agents and Chemotherapy. 54: 5366-8. PMID 20876376 DOI: 10.1128/AAC.00719-10  1
2010 Dhamdhere G, Zgurskaya HI. Metabolic shutdown in Escherichia coli cells lacking the outer membrane channel TolC. Molecular Microbiology. 77: 743-54. PMID 20545840 DOI: 10.1111/j.1365-2958.2010.07245.x  1
2009 Tikhonova EB, Dastidar V, Rybenkov VV, Zgurskaya HI. Kinetic control of TolC recruitment by multidrug efflux complexes. Proceedings of the National Academy of Sciences of the United States of America. 106: 16416-21. PMID 19805313 DOI: 10.1073/pnas.0906601106  1
2009 Inwood WB, Hall JA, Kim KS, Demirkhanyan L, Wemmer D, Zgurskaya H, Kustu S. Epistatic effects of the protease/chaperone HflB on some damaged forms of the Escherichia coli ammonium channel AmtB. Genetics. 183: 1327-40. PMID 19596908 DOI: 10.1534/genetics.109.103747  1
2009 Ge Q, Yamada Y, Zgurskaya H. The C-terminal domain of AcrA is essential for the assembly and function of the multidrug efflux pump AcrAB-TolC. Journal of Bacteriology. 191: 4365-71. PMID 19411330 DOI: 10.1128/JB.00204-09  0.6
2009 Zgurskaya HI, Yamada Y, Tikhonova EB, Ge Q, Krishnamoorthy G. Structural and functional diversity of bacterial membrane fusion proteins. Biochimica Et Biophysica Acta. 1794: 794-807. PMID 19041958 DOI: 10.1016/j.bbapap.2008.10.010  1
2008 Krishnamoorthy G, Tikhonova EB, Zgurskaya HI. Fitting periplasmic membrane fusion proteins to inner membrane transporters: mutations that enable Escherichia coli AcrA to function with Pseudomonas aeruginosa MexB. Journal of Bacteriology. 190: 691-8. PMID 18024521 DOI: 10.1128/JB.01276-07  1
2007 Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI. Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB. Molecular Microbiology. 63: 895-910. PMID 17214741 DOI: 10.1111/j.1365-2958.2006.05549.x  1
2007 Lomovskaya O, Zgurskaya HI, Totrov M, Watkins WJ. Waltzing transporters and 'the dance macabre' between humans and bacteria. Nature Reviews. Drug Discovery. 6: 56-65. PMID 17159924 DOI: 10.1038/nrd2200  1
2006 Mikolosko J, Bobyk K, Zgurskaya HI, Ghosh P. Conformational flexibility in the multidrug efflux system protein AcrA. Structure (London, England : 1993). 14: 577-87. PMID 16531241 DOI: 10.1016/j.str.2005.11.015  1
2005 Lau SY, Zgurskaya HI. Cell division defects in Escherichia coli deficient in the multidrug efflux transporter AcrEF-TolC. Journal of Bacteriology. 187: 7815-25. PMID 16267305 DOI: 10.1128/JB.187.22.7815-7825.2005  1
2004 Zakharov SD, Eroukova VY, Rokitskaya TI, Zhalnina MV, Sharma O, Loll PJ, Zgurskaya HI, Antonenko YN, Cramer WA. Colicin occlusion of OmpF and TolC channels: outer membrane translocons for colicin import. Biophysical Journal. 87: 3901-11. PMID 15465872 DOI: 10.1529/biophysj.104.046151  1
2004 Tikhonova EB, Zgurskaya HI. AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex. The Journal of Biological Chemistry. 279: 32116-24. PMID 15155734 DOI: 10.1074/jbc.M402230200  0.8
2003 Zgurskaya HI, Krishnamoorthy G, Tikhonova EB, Lau SY, Stratton KL. Mechanism of antibiotic efflux in Gram-negative bacteria. Frontiers in Bioscience : a Journal and Virtual Library. 8: s862-73. PMID 12957812  1
2003 Yu EW, McDermott G, Zgurskaya HI, Nikaido H, Koshland DE. Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump Science. 300: 976-980. PMID 12738864 DOI: 10.1126/science.1083137  1
2002 Lomovskaya O, Zgurskaya HI, Nikaido H. It takes three to tango Nature Biotechnology. 20: 1210-1212. PMID 12454673 DOI: 10.1038/nbt1202-1210  1
2002 Tikhonova EB, Wang Q, Zgurskaya HI. Chimeric analysis of the multicomponent multidrug efflux transporters from gram-negative bacteria. Journal of Bacteriology. 184: 6499-507. PMID 12426337  0.8
2002 Zgurskaya HI, Nikaido H. Mechanistic parallels in bacterial and human multidrug efflux transporters Current Protein and Peptide Science. 3: 531-540. PMID 12370000 DOI: 10.2174/1389203023380512  1
2001 Avila-Sakar AJ, Misaghi S, Wilson-Kubalek EM, Downing KH, Zgurskaya H, Nikaido H, Nogales E. Lipid-layer crystallization and preliminary three-dimensional structural analysis of AcrA, the periplasmic component of a bacterial multidrug efflux pump Journal of Structural Biology. 136: 81-88. PMID 11858709 DOI: 10.1006/jsbi.2001.4418  1
2000 Zgurskaya HI, Nikaido H. Multidrug resistance mechanisms: Drug efflux across two membranes Molecular Microbiology. 37: 219-225. PMID 10931319 DOI: 10.1046/j.1365-2958.2000.01926.x  1
2000 Zgurskaya HI, Nikaido H. Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coli Journal of Bacteriology. 182: 4264-4267. PMID 10894736 DOI: 10.1128/JB.182.15.4264-4267.2000  1
1999 Nikaido H, Zgurskaya HI. Antibiotic efflux mechanisms. Current Opinion in Infectious Diseases. 12: 529-36. PMID 17035817 DOI: 10.1097/00001432-199912000-00001  1
1999 Zgurskaya HI, Nikaido H. Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 96: 7190-5. PMID 10377390 DOI: 10.1073/pnas.96.13.7190  1
1999 Zgurskaya HI, Nikaido H. AcrA is a highly asymmetric protein capable of spanning the periplasm. Journal of Molecular Biology. 285: 409-20. PMID 9878415 DOI: 10.1006/jmbi.1998.2313  1
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