Richard Bridges - Publications

Affiliations: 
Integrative Microbiology & Biochemistry University of Montana, Missoula, MT 
Area:
Microbiology Biology

37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Hitt DM, Zwicker JD, Chao CK, Patel SA, Gerdes JM, Bridges RJ, Thompson CM. Inhibition of the Vesicular Glutamate Transporter (VGLUT) with Congo Red Analogs: New Binding Insights. Neurochemical Research. PMID 33398639 DOI: 10.1007/s11064-020-03182-0  0.96
2014 Carrigan CN, Patel SA, Cox HD, Bolstad ES, Gerdes JM, Smith WE, Bridges RJ, Thompson CM. The development of benzo- and naphtho-fused quinoline-2,4-dicarboxylic acids as vesicular glutamate transporter (VGLUT) inhibitors reveals a possible role for neuroactive steroids. Bioorganic & Medicinal Chemistry Letters. 24: 850-4. PMID 24424130 DOI: 10.1016/j.bmcl.2013.12.086  0.96
2014 Newell JL, Keyari CM, McDaniel SW, Diaz PJ, Natale NR, Patel SA, Bridges RJ. Novel di-aryl-substituted isoxazoles act as noncompetitive inhibitors of the system Xc(-) cystine/glutamate exchanger. Neurochemistry International. 73: 132-8. PMID 24333322 DOI: 10.1016/j.neuint.2013.11.012  0.96
2013 Matti AA, Mirzaei J, Rudolph J, Smith SA, Newell JL, Patel SA, Braden MR, Bridges RJ, Natale NR. Microwave accelerated synthesis of isoxazole hydrazide inhibitors of the system xc- transporter: Initial homology model. Bioorganic & Medicinal Chemistry Letters. 23: 5931-5. PMID 24042010 DOI: 10.1016/j.bmcl.2013.08.080  0.96
2012 Bridges R, Lutgen V, Lobner D, Baker DA. Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling. Pharmacological Reviews. 64: 780-802. PMID 22759795 DOI: 10.1124/pr.110.003889  0.96
2012 Sontheimer H, Bridges RJ. Sulfasalazine for brain cancer fits Expert Opinion On Investigational Drugs. 21: 575-578. PMID 22404218 DOI: 10.1517/13543784.2012.670634  0.96
2012 Bridges RJ, Natale NR, Patel SA. System xc⁻ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS. British Journal of Pharmacology. 165: 20-34. PMID 21564084 DOI: 10.1111/j.1476-5381.2011.01480.x  0.96
2011 Pathmajeyan MS, Patel SA, Carroll JA, Seib T, Striebel JF, Bridges RJ, Chesebro B. Increased excitatory amino acid transport into murine prion protein knockout astrocytes cultured in vitro. Glia. 59: 1684-94. PMID 21766339 DOI: 10.1002/glia.21215  0.96
2011 Ahmed SK, Etoga JL, Patel SA, Bridges RJ, Thompson CM. Use of the hydantoin isostere to produce inhibitors showing selectivity toward the vesicular glutamate transporter versus the obligate exchange transporter system x(c)(-). Bioorganic & Medicinal Chemistry Letters. 21: 4358-62. PMID 21669531 DOI: 10.1016/j.bmcl.2011.05.018  0.96
2011 Seib TM, Patel SA, Bridges RJ. Regulation of the system x(C)- cystine/glutamate exchanger by intracellular glutathione levels in rat astrocyte primary cultures. Glia. 59: 1387-401. PMID 21590811 DOI: 10.1002/glia.21176  0.96
2010 Ye R, Rhoderick JF, Thompson CM, Bridges RJ. Functional expression, purification and high sequence coverage mass spectrometric characterization of human excitatory amino acid transporter EAAT2. Protein Expression and Purification. 74: 49-59. PMID 20399272 DOI: 10.1016/j.pep.2010.04.006  0.76
2010 Etoga JL, Ahmed SK, Patel S, Bridges RJ, Thompson CM. Conformationally-restricted amino acid analogues bearing a distal sulfonic acid show selective inhibition of system x(c)(-) over the vesicular glutamate transporter. Bioorganic & Medicinal Chemistry Letters. 20: 2680-3. PMID 20303751 DOI: 10.1016/j.bmcl.2009.10.020  0.44
2010 Patel SA, Rajale T, O'Brien E, Burkhart DJ, Nelson JK, Twamley B, Blumenfeld A, Szabon-Watola MI, Gerdes JM, Bridges RJ, Natale NR. Isoxazole analogues bind the system xc- transporter: structure-activity relationship and pharmacophore model. Bioorganic & Medicinal Chemistry. 18: 202-13. PMID 19932968 DOI: 10.1016/j.bmc.2009.11.001  0.96
2010 Balazs R, Bridges RJ, Cotman CW, Cotman CA. Excitatory Amino Acid Transmission in Health and Disease Excitatory Amino Acid Transmission in Health and Disease. 1-380. DOI: 10.1093/acprof:oso/9780195150025.001.0001  0.96
2009 Bridges RJ, Patel SA. Pharmacology of glutamate transport in the cns: Substrates and inhibitors of excitatory amino acid transporters (EAATs) and the glutamate/cystine exchanger system x c- Topics in Medicinal Chemistry. 4: 187-222. DOI: 10.1007/7355_2008_026  0.96
2008 Natale NR, Szabon-Watola MI, Twamley B, Bridges RJ, Patel S, Rajale T. Ethyl 4-{1-[(2,4-dinitro-phen-yl)hydrazono]eth-yl}-5-(2-naphthyl-methoxy-meth-yl)isoxazole-3-carboxyl-ate. Acta Crystallographica. Section E, Structure Reports Online. 65: o144-5. PMID 21581603 DOI: 10.1107/S1600536808041901  0.48
2008 Mavencamp TL, Rhoderick JF, Bridges RJ, Esslinger CS. Synthesis and preliminary pharmacological evaluation of novel derivatives of L-beta-threo-benzylaspartate as inhibitors of the neuronal glutamate transporter EAAT3. Bioorganic & Medicinal Chemistry. 16: 7740-8. PMID 18650095 DOI: 10.1016/j.bmc.2008.07.001  0.96
2005 Esslinger CS, Agarwal S, Gerdes J, Wilson PA, Davis ES, Awes AN, O'Brien E, Mavencamp T, Koch HP, Poulsen DJ, Rhoderick JF, Chamberlin AR, Kavanaugh MP, Bridges RJ. The substituted aspartate analogue L-beta-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3. Neuropharmacology. 49: 850-61. PMID 16183084 DOI: 10.1016/j.neuropharm.2005.08.009  0.96
2005 Bridges RJ, Esslinger CS. The excitatory amino acid transporters: pharmacological insights on substrate and inhibitor specificity of the EAAT subtypes. Pharmacology & Therapeutics. 107: 271-85. PMID 16112332 DOI: 10.1016/j.pharmthera.2005.01.002  0.96
2005 Thompson CM, Davis E, Carrigan CN, Cox HD, Bridges RJ, Gerdes JM. Inhibitor of the glutamate vesicular transporter (VGLUT). Current Medicinal Chemistry. 12: 2041-56. PMID 16101493 DOI: 10.2174/0929867054637635  0.96
2004 Warren BA, Patel SA, Nunn PB, Bridges RJ. The Lathyrus excitotoxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid is a substrate of the L-cystine/L-glutamate exchanger system xc-. Toxicology and Applied Pharmacology. 200: 83-92. PMID 15476861 DOI: 10.1016/j.taap.2004.04.001  0.96
2004 Patel SA, Warren BA, Rhoderick JF, Bridges RJ. Differentiation of substrate and non-substrate inhibitors of transport system xc(-): an obligate exchanger of L-glutamate and L-cystine. Neuropharmacology. 46: 273-84. PMID 14680765 DOI: 10.1016/j.neuropharm.2003.08.006  0.96
2002 Denton T, Seib T, Bridges R, Thompson C. Synthesis and preliminary evaluation of trans-3,4-conformationally-restricted glutamate and pyroglutamate analogues as novel EAAT2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 12: 3209-13. PMID 12372536 DOI: 10.1016/S0960-894X(02)00520-6  0.96
2002 Esslinger CS, Titus J, Koch HP, Bridges RJ, Chamberlin AR. Methylation of l-trans-2,4-pyrrolidine dicarboxylate converts the glutamate transport inhibitor from a substrate to a non-substrate inhibitor Bioorganic and Medicinal Chemistry. 10: 3509-3515. PMID 12213465 DOI: 10.1016/S0968-0896(02)00250-X  0.96
2002 Carrigan CN, Bartlett RD, Esslinger CS, Cybulski KA, Tongcharoensirikul P, Bridges RJ, Thompson CM. Synthesis and in vitro pharmacology of substituted quinoline-2,4-dicarboxylic acids as inhibitors of vesicular glutamate transport. Journal of Medicinal Chemistry. 45: 2260-76. PMID 12014964 DOI: 10.1021/jm010261z  0.96
1998 Bartlett RD, Esslinger CS, Thompson CM, Bridges RJ. Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology. 37: 839-46. PMID 9776380 DOI: 10.1016/S0028-3908(98)00080-X  0.96
1997 Willis CL, Dauenhauer DL, Humphrey JM, Chamberlin AR, Buller AL, Monaghan DT, Bridges RJ. Methylation of the NMDA receptor agonist L-trans-2,3-pyrrolidine-dicarboxylate: enhanced excitotoxic potency and selectivity. Toxicology and Applied Pharmacology. 144: 45-55. PMID 9169068 DOI: 10.1006/taap.1997.8112  0.96
1996 Willis CL, Humphrey JM, Koch HP, Hart JA, Blakely T, Ralston L, Baker CA, Shim S, Kadri M, Chamberlin AR, Bridges RJ. L-trans-2,3-pyrrolidine dicarboxylate: characterization of a novel excitotoxin. Neuropharmacology. 35: 531-9. PMID 8887961 DOI: 10.1016/0028-3908(96)84623-5  0.96
1996 Sonnenberg JD, Koch HP, Willis CL, Bradbury P, Dauenhauer D, Bridges RJ, Chamberlin AR. The role of the C-4 side chain of kainate and dihydrokainate in EAA receptor and transporter selectivity Bioorganic and Medicinal Chemistry Letters. 6: 1607-1612. DOI: 10.1016/S0960-894X(96)00284-3  0.96
1993 Bridges RJ, Lovering FE, Humphrey JM, Stanley MS, Blakely TN, Cristofaro MF, Chamberlin AR. Conformationally restricted inhibitors of the high affinity L-glutamate transporter Bioorganic and Medicinal Chemistry Letters. 3: 115-121. DOI: 10.1016/S0960-894X(00)80103-1  0.96
1991 Kirstein CL, Coopersmith R, Bridges RJ, Leon M. Glutathione levels in olfactory and non-olfactory neural structures of rats. Brain Research. 543: 341-6. PMID 1711912 DOI: 10.1016/0006-8993(91)90047-Y  0.96
1991 Anderson KJ, Bridges RJ, Cotman CW. Increased density of excitatory amino acid transport sites in the hippocampal formation following an entorhinal lesion Brain Research. 562: 285-290. PMID 1685344 DOI: 10.1016/0006-8993(91)90633-7  0.96
1990 Anderson KJ, Monaghan DT, Bridges RJ, Tavoularis AL, Cotman CW. Autoradiographic characterization of putative excitatory amino acid transport sites Neuroscience. 38: 311-322. PMID 1979852 DOI: 10.1016/0306-4522(90)90030-8  0.96
1989 Cotman CW, Geddes JW, Bridges RJ, Monaghan DT. N-methyl-D-aspartate receptors and Alzheimer's disease Neurobiology of Aging. 10: 603-605. PMID 2572983 DOI: 10.1016/0197-4580(89)90144-9  0.96
1988 Bridges RJ, Kadri MM, Monaghan DT, Nunn PB, Watkins JC, Cotman CW. Inhibition of [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding by the excitotoxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid. European Journal of Pharmacology. 145: 357-9. PMID 2895006 DOI: 10.1016/0014-2999(88)90442-6  0.96
1987 Bridges RJ, Kesslak JP, Nieto-Sampedro M, Broderick JT, Yu J, Cotman CW. A L-[3H]glutamate binding site on glia: an autoradiographic study on implanted astrocytes. Brain Research. 415: 163-8. PMID 2887242 DOI: 10.1016/0006-8993(87)90281-2  0.96
1986 Bridges RJ, Hearn TJ, Monaghan DT, Cotman CW. A comparison of 2-amino-4-phosphonobutyric acid (AP4) receptors and [3H]AP4 binding sites in the rat brain Brain Research. 375: 204-209. PMID 3013370 DOI: 10.1016/0006-8993(86)90977-7  0.96
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