JoAnne L. Flynn - Publications

Affiliations: 
University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Immunology, Microbiology Biology

110 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Darrah PA, DiFazio RM, Maiello P, Gideon HP, Myers AJ, Rodgers MA, Hackney JA, Lindenstrom T, Evans T, Scanga CA, Prikhodko V, Andersen P, Lin PL, Laddy D, Roederer M, ... ... Flynn JL, et al. Boosting BCG with proteins or rAd5 does not enhance protection against tuberculosis in rhesus macaques. Npj Vaccines. 4: 21. PMID 31149352 DOI: 10.1038/s41541-019-0113-9  1
2018 Ganchua SKC, Cadena AM, Maiello P, Gideon HP, Myers AJ, Junecko BF, Klein EC, Lin PL, Mattila JT, Flynn JL. Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques. Plos Pathogens. 14: e1007337. PMID 30383808 DOI: 10.1371/journal.ppat.1007337  0.6
2018 Lin PL, Flynn JL. The End of the Binary Era: Revisiting the Spectrum of Tuberculosis. Journal of Immunology (Baltimore, Md. : 1950). 201: 2541-2548. PMID 30348659 DOI: 10.4049/jimmunol.1800993  0.32
2018 Cadena AM, Hopkins FF, Maiello P, Carey AF, Wong EA, Martin CJ, Gideon HP, DiFazio RM, Andersen P, Lin PL, Fortune SM, Flynn JL. Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques. Plos Pathogens. 14: e1007305. PMID 30312351 DOI: 10.1371/journal.ppat.1007305  0.32
2018 Cadena AM, Ma Y, Ding T, Bryant M, Maiello P, Geber A, Lin PL, Flynn JL, Ghedin E. Profiling the airway in the macaque model of tuberculosis reveals variable microbial dysbiosis and alteration of community structure. Microbiome. 6: 180. PMID 30301469 DOI: 10.1186/s40168-018-0560-y  0.32
2018 Mellors TR, Nasir M, Franchina FA, Smolinska A, Blanchet L, Flynn J, Tomko JA, O'Malley MJ, Scanga CA, Lin PL, Wagner J, Hill JE. Identification of Mycobacterium tuberculosis using volatile biomarkers in culture and exhaled breath. Journal of Breath Research. PMID 29910196 DOI: 10.1088/1752-7163/aacd18  1
2018 Wong EA, Joslyn L, Grant NL, Klein E, Lin PL, Kirschner DE, Flynn JL. Low levels of T cell exhaustion in tuberculous lung granulomas. Infection and Immunity. PMID 29891540 DOI: 10.1128/IAI.00426-18  0.32
2018 Thompson EG, Shankar S, Gideon HP, Braun J, Valvo J, Skinner J, Aderem A, Flynn JL, Lin PL, Zak DE. Blood RNA signatures prospectively discriminate controllers from progressors early after low-dose M. tuberculosis infection of cynomolgus macaques. The Journal of Infectious Diseases. PMID 29325117 DOI: 10.1093/infdis/jiy006  0.32
2017 Maiello P, DiFazio RM, Cadena AM, Rodgers MA, Lin PL, Scanga CA, Flynn JL. Rhesus macaques are more susceptible to progressive tuberculosis than cynomolgus macaques: A quantitative comparison. Infection and Immunity. PMID 28947646 DOI: 10.1128/IAI.00505-17  1
2017 White AG, Maiello P, Coleman MT, Tomko JA, Frye LJ, Scanga CA, Lin PL, Flynn JL. Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates. Journal of Visualized Experiments : Jove. PMID 28930979 DOI: 10.3791/56375  1
2017 Mattila JT, Beaino W, Maiello P, Coleman MT, White AG, Scanga CA, Flynn JL, Anderson CJ. Positron Emission Tomography Imaging of Macaques with Tuberculosis Identifies Temporal Changes in Granuloma Glucose Metabolism and Integrin α4β1-Expressing Immune Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 28592427 DOI: 10.4049/jimmunol.1700231  1
2017 Rockwood N, Costa DL, Amaral EP, Du Bruyn E, Kubler A, Gil-Santana L, Fukutani KF, Scanga CA, Flynn JL, Jackson SH, Wilkinson KA, Bishai WR, Sher A, Wilkinson RJ, Andrade BB. Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes. Frontiers in Immunology. 8: 542. PMID 28553288 DOI: 10.3389/fimmu.2017.00542  1
2017 Martin CJ, Cadena AM, Leung VW, Lin PL, Maiello P, Hicks N, Chase MR, Flynn JL, Fortune SM. Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis. Mbio. 8. PMID 28487426 DOI: 10.1128/mBio.00312-17  0.32
2017 Wonderlich ER, Swan ZD, Bissel SJ, Hartman AL, Carney JP, O'Malley KJ, Obadan AO, Santos J, Walker R, Sturgeon TJ, Frye LJ, Maiello P, Scanga CA, Bowling JD, Bouwer AL, ... ... Flynn JL, et al. Widespread Virus Replication in Alveoli Drives Acute Respiratory Distress Syndrome in Aerosolized H5N1 Influenza Infection of Macaques. Journal of Immunology (Baltimore, Md. : 1950). PMID 28062701 DOI: 10.4049/jimmunol.1601770  1
2017 Mellors TR, Blanchet L, Flynn JL, Tomko J, O'Malley M, Scanga CA, Lin PL, Hill JE. A new method to evaluate macaque health using exhaled breath: A case study of M. tuberculosis in a BSL-3 setting. Journal of Applied Physiology (Bethesda, Md. : 1985). jap.00888.2016. PMID 28057819 DOI: 10.1152/japplphysiol.00888.2016  1
2016 Gideon HP, Skinner JA, Baldwin N, Flynn JL, Lin PL. Early Whole Blood Transcriptional Signatures Are Associated with Severity of Lung Inflammation in Cynomolgus Macaques with Mycobacterium tuberculosis Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 27837110 DOI: 10.4049/jimmunol.1601138  0.32
2016 Cadena AM, Klein EC, White AG, Tomko JA, Chedrick CL, Reed DS, Via LE, Lin PL, Flynn JL. Very Low Doses of Mycobacterium tuberculosis Yield Diverse Host Outcomes in Common Marmosets (Callithrix jacchus). Comparative Medicine. 66: 412-419. PMID 27780009  0.32
2016 Esmail H, Lai RP, Lesosky M, Wilkinson KA, Graham CM, Coussens AK, Oni T, Warwick JM, Said-Hartley Q, Koegelenberg CF, Walzl G, Flynn JL, Young DB, Barry Iii CE, O'Garra A, et al. Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography. Nature Medicine. PMID 27595321 DOI: 10.1038/nm.4161  1
2016 Lin PL, Maiello P, Gideon HP, Coleman MT, Cadena AM, Rodgers MA, Gregg R, O'Malley M, Tomko J, Fillmore D, Frye LJ, Rutledge T, DiFazio RM, Janssen C, Klein E, ... ... Flynn JL, et al. PET CT Identifies Reactivation Risk in Cynomolgus Macaques with Latent M. tuberculosis. Plos Pathogens. 12: e1005739. PMID 27379816 DOI: 10.1371/journal.ppat.1005739  1
2016 DiFazio RM, Mattila JT, Klein EC, Cirrincione LR, Howard M, Wong EA, Flynn JL. Active transforming growth factor-β is associated with phenotypic changes in granulomas after drug treatment in pulmonary tuberculosis. Fibrogenesis & Tissue Repair. 9: 6. PMID 27148404 DOI: 10.1186/s13069-016-0043-3  1
2016 Marino S, Gideon HP, Gong C, Mankad S, McCrone JT, Lin PL, Linderman JJ, Flynn JL, Kirschner DE. Computational and Empirical Studies Predict Mycobacterium tuberculosis-Specific T Cells as a Biomarker for Infection Outcome. Plos Computational Biology. 12: e1004804. PMID 27065304 DOI: 10.1371/journal.pcbi.1004804  1
2016 Banada PP, Naidoo U, Deshpande S, Karim F, Flynn JL, O'Malley M, Jones M, Nanassy O, Jeena P, Alland D. A Novel Sample Processing Method for Rapid Detection of Tuberculosis in the Stool of Pediatric Patients Using the Xpert MTB/RIF Assay. Plos One. 11: e0151980. PMID 27007974 DOI: 10.1371/journal.pone.0151980  0.32
2016 Phuah J, Wong EA, Gideon HP, Maiello P, Coleman MT, Hendricks MR, Ruden R, Cirrincione LR, Chan J, Lin PL, Flynn JL. The Effects of B cell Depletion on early Mycobacterium tuberculosis infection in Cynomolgus Macaques. Infection and Immunity. PMID 26883591 DOI: 10.1128/IAI.00083-16  1
2015 Mothé BR, Lindestam Arlehamn CS, Dow C, Dillon MB, Wiseman RW, Bohn P, Karl J, Golden NA, Gilpin T, Foreman TW, Rodgers MA, Mehra S, Scriba TJ, Flynn JL, Kaushal D, et al. The TB-specific CD4(+) T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans. Tuberculosis (Edinburgh, Scotland). PMID 26526557 DOI: 10.1016/j.tube.2015.07.005  1
2015 Via LE, England K, Weiner DM, Schimel D, Zimmerman MD, Dayao E, Chen RY, Dodd LE, Richardson M, Robbins KK, Cai Y, Hammoud D, Herscovitch P, Dartois V, Flynn JL, et al. A Sterilizing Tuberculosis Treatment Regimen Is Associated with Faster Clearance of Bacteria in Cavitary Lesions in Marmosets. Antimicrobial Agents and Chemotherapy. 59: 4181-9. PMID 25941223 DOI: 10.1128/AAC.00115-15  1
2015 Lin PL, Flynn JL. CD8 T cells and Mycobacterium tuberculosis infection. Seminars in Immunopathology. 37: 239-49. PMID 25917388 DOI: 10.1007/s00281-015-0490-8  0.32
2015 Flynn JL, Gideon HP, Mattila JT, Lin PL. Immunology studies in non-human primate models of tuberculosis. Immunological Reviews. 264: 60-73. PMID 25703552 DOI: 10.1111/imr.12258  1
2015 Wolf TM, Mugisha L, Shoyama FM, O'Malley MJ, Flynn JL, Asiimwe B, Travis DA, Singer RS, Sreevatsan S. Noninvasive test for tuberculosis detection among primates. Emerging Infectious Diseases. 21: 468-70. PMID 25695329 DOI: 10.3201/eid2103.140052  1
2015 Mattila JT, Maiello P, Sun T, Via LE, Flynn JL. Granzyme B-expressing neutrophils correlate with bacterial load in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques. Cellular Microbiology. PMID 25653138 DOI: 10.1111/cmi.12428  1
2015 Gideon HP, Phuah J, Myers AJ, Bryson BD, Rodgers MA, Coleman MT, Maiello P, Rutledge T, Marino S, Fortune SM, Kirschner DE, Lin PL, Flynn JL. Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization. Plos Pathogens. 11: e1004603. PMID 25611466 DOI: 10.1371/journal.ppat.1004603  1
2015 Cilfone NA, Ford CB, Marino S, Mattila JT, Gideon HP, Flynn JL, Kirschner DE, Linderman JJ. Computational modeling predicts IL-10 control of lesion sterilization by balancing early host immunity-mediated antimicrobial responses with caseation during mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 194: 664-77. PMID 25512604 DOI: 10.4049/jimmunol.1400734  1
2015 Pienaar E, Cilfone NA, Lin PL, Dartois V, Mattila JT, Butler JR, Flynn JL, Kirschner DE, Linderman JJ. A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment. Journal of Theoretical Biology. 367: 166-79. PMID 25497475 DOI: 10.1016/j.jtbi.2014.11.021  1
2015 Marino S, Cilfone NA, Mattila JT, Linderman JJ, Flynn JL, Kirschner DE. Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection. Infection and Immunity. 83: 324-38. PMID 25368116 DOI: 10.1128/IAI.02494-14  1
2014 Coleman MT, Chen RY, Lee M, Lin PL, Dodd LE, Maiello P, Via LE, Kim Y, Marriner G, Dartois V, Scanga C, Janssen C, Wang J, Klein E, Cho SN, ... ... Flynn JL, et al. PET/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis. Science Translational Medicine. 6: 265ra167. PMID 25473035 DOI: 10.1126/scitranslmed.3009500  1
2014 Scanga CA, Flynn JL. Modeling tuberculosis in nonhuman primates. Cold Spring Harbor Perspectives in Medicine. 4: a018564. PMID 25213189 DOI: 10.1101/cshperspect.a018564  1
2014 Kling HM, Nau GJ, Ross TM, Evans TG, Chakraborty K, Empey KM, Flynn JL. Challenges and future in vaccines, drug development, and immunomodulatory therapy. Annals of the American Thoracic Society. 11: S201-10. PMID 25148426 DOI: 10.1513/AnnalsATS.201401-036PL  1
2014 Scanga CA, Lopresti BJ, Tomko J, Frye LJ, Coleman TM, Fillmore D, Carney JP, Lin PL, Flynn JL, Gardner CL, Sun C, Klimstra WB, Ryman KD, Reed DS, Fisher DJ, et al. In vivo imaging in an ABSL-3 regional biocontainment laboratory. Pathogens and Disease. 71: 207-12. PMID 24838691 DOI: 10.1111/2049-632X.12186  1
2014 Ravindran R, Krishnan VV, Dhawan R, Wunderlich ML, Lerche NW, Flynn JL, Luciw PA, Khan IH. Plasma antibody profiles in non-human primate tuberculosis. Journal of Medical Primatology. 43: 59-71. PMID 24446897 DOI: 10.1111/jmp.12097  1
2014 Lin PL, Ford CB, Coleman MT, Myers AJ, Gawande R, Ioerger T, Sacchettini J, Fortune SM, Flynn JL. Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing. Nature Medicine. 20: 75-9. PMID 24336248 DOI: 10.1038/nm.3412  1
2013 Kozakiewicz L, Chen Y, Xu J, Wang Y, Dunussi-Joannopoulos K, Ou Q, Flynn JL, Porcelli SA, Jacobs WR, Chan J. B cells regulate neutrophilia during Mycobacterium tuberculosis infection and BCG vaccination by modulating the interleukin-17 response. Plos Pathogens. 9: e1003472. PMID 23853593 DOI: 10.1371/journal.ppat.1003472  1
2013 Gong C, Mattila JT, Miller M, Flynn JL, Linderman JJ, Kirschner D. Predicting lymph node output efficiency using systems biology. Journal of Theoretical Biology. 335: 169-84. PMID 23816876 DOI: 10.1016/j.jtbi.2013.06.016  1
2013 Lin PL, Coleman T, Carney JP, Lopresti BJ, Tomko J, Fillmore D, Dartois V, Scanga C, Frye LJ, Janssen C, Klein E, Barry CE, Flynn JL. Radiologic responses in cynomolgous macaques for assessing tuberculosis chemotherapy regimens. Antimicrobial Agents and Chemotherapy. PMID 23796926 DOI: 10.1128/AAC.00277-13  0.32
2013 Mattila JT, Ojo OO, Kepka-Lenhart D, Marino S, Kim JH, Eum SY, Via LE, Barry CE, Klein E, Kirschner DE, Morris SM, Lin PL, Flynn JL. Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms. Journal of Immunology (Baltimore, Md. : 1950). 191: 773-84. PMID 23749634 DOI: 10.4049/jimmunol.1300113  1
2013 Via LE, Weiner DM, Schimel D, Lin PL, Dayao E, Tankersley SL, Cai Y, Coleman MT, Tomko J, Paripati P, Orandle M, Kastenmayer RJ, Tartakovsky M, Rosenthal A, Portevin D, ... ... Flynn JL, et al. Differential virulence and disease progression following Mycobacterium tuberculosis complex infection of the common marmoset (Callithrix jacchus). Infection and Immunity. 81: 2909-19. PMID 23716617 DOI: 10.1128/IAI.00632-13  1
2013 Diedrich CR, Mattila JT, Flynn JL. Monocyte-derived IL-5 reduces TNF production by Mycobacterium tuberculosis-specific CD4 T cells during SIV/M. tuberculosis coinfection. Journal of Immunology (Baltimore, Md. : 1950). 190: 6320-8. PMID 23690470 DOI: 10.4049/jimmunol.1202043  1
2013 Myers AJ, Marino S, Kirschner DE, Flynn JL. Inoculation dose of Mycobacterium tuberculosis does not influence priming of T cell responses in lymph nodes. Journal of Immunology (Baltimore, Md. : 1950). 190: 4707-16. PMID 23547119 DOI: 10.4049/jimmunol.1203465  1
2013 Ragheb MN, Ford CB, Chase MR, Lin PL, Flynn JL, Fortune SM. The mutation rate of mycobacterial repetitive unit loci in strains of M. tuberculosis from cynomolgus macaque infection. Bmc Genomics. 14: 145. PMID 23496945 DOI: 10.1186/1471-2164-14-145  1
2013 Green AM, Difazio R, Flynn JL. IFN-γ from CD4 T cells is essential for host survival and enhances CD8 T cell function during Mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 190: 270-7. PMID 23233724 DOI: 10.4049/jimmunol.1200061  1
2012 Lin PL, Dartois V, Johnston PJ, Janssen C, Via L, Goodwin MB, Klein E, Barry CE, Flynn JL. Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques. Proceedings of the National Academy of Sciences of the United States of America. 109: 14188-93. PMID 22826237 DOI: 10.1073/pnas.1121497109  1
2012 Kunnath-Velayudhan S, Davidow AL, Wang HY, Molina DM, Huynh VT, Salamon H, Pine R, Michel G, Perkins MD, Xiaowu L, Felgner PL, Flynn JL, Catanzaro A, Gennaro ML. Proteome-scale antibody responses and outcome of Mycobacterium tuberculosis infection in nonhuman primates and in tuberculosis patients. The Journal of Infectious Diseases. 206: 697-705. PMID 22732925 DOI: 10.1093/infdis/jis421  1
2012 Phuah JY, Mattila JT, Lin PL, Flynn JL. Activated B cells in the granulomas of nonhuman primates infected with Mycobacterium tuberculosis. The American Journal of Pathology. 181: 508-14. PMID 22721647 DOI: 10.1016/j.ajpath.2012.05.009  1
2012 Via LE, Schimel D, Weiner DM, Dartois V, Dayao E, Cai Y, Yoon YS, Dreher MR, Kastenmayer RJ, Laymon CM, Carny JE, Flynn JL, Herscovitch P, Barry CE. Infection dynamics and response to chemotherapy in a rabbit model of tuberculosis using [¹⁸F]2-fluoro-deoxy-D-glucose positron emission tomography and computed tomography. Antimicrobial Agents and Chemotherapy. 56: 4391-402. PMID 22687508 DOI: 10.1128/AAC.00531-12  1
2012 Lin PL, Rutledge T, Green AM, Bigbee M, Fuhrman C, Klein E, Flynn JL. CD4 T cell depletion exacerbates acute Mycobacterium tuberculosis while reactivation of latent infection is dependent on severity of tissue depletion in cynomolgus macaques. Aids Research and Human Retroviruses. 28: 1693-702. PMID 22480184 DOI: 10.1089/AID.2012.0028  1
2012 Fallahi-Sichani M, Flynn JL, Linderman JJ, Kirschner DE. Differential risk of tuberculosis reactivation among anti-TNF therapies is due to drug binding kinetics and permeability. Journal of Immunology (Baltimore, Md. : 1950). 188: 3169-78. PMID 22379032 DOI: 10.4049/jimmunol.1103298  1
2012 Lin PL, Dietrich J, Tan E, Abalos RM, Burgos J, Bigbee C, Bigbee M, Milk L, Gideon HP, Rodgers M, Cochran C, Guinn KM, Sherman DR, Klein E, Janssen C, ... Flynn JL, et al. The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection. The Journal of Clinical Investigation. 122: 303-14. PMID 22133873 DOI: 10.1172/JCI46252  1
2011 Zinman G, Brower-Sinning R, Emeche CH, Ernst J, Huang GT, Mahony S, Myers AJ, O'Dee DM, Flynn JL, Nau GJ, Ross TM, Salter RD, Benos PV, Bar Joseph Z, Morel PA. Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque. Plos One. 6: e22401. PMID 21789257 DOI: 10.1371/journal.pone.0022401  1
2011 Ford CB, Lin PL, Chase MR, Shah RR, Iartchouk O, Galagan J, Mohaideen N, Ioerger TR, Sacchettini JC, Lipsitch M, Flynn JL, Fortune SM. Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection. Nature Genetics. 43: 482-6. PMID 21516081 DOI: 10.1038/ng.811  1
2011 Mattila JT, Diedrich CR, Lin PL, Phuah J, Flynn JL. Simian immunodeficiency virus-induced changes in T cell cytokine responses in cynomolgus macaques with latent Mycobacterium tuberculosis infection are associated with timing of reactivation. Journal of Immunology (Baltimore, Md. : 1950). 186: 3527-37. PMID 21317393 DOI: 10.4049/jimmunol.1003773  1
2011 Diedrich CR, Flynn JL. HIV-1/mycobacterium tuberculosis coinfection immunology: how does HIV-1 exacerbate tuberculosis? Infection and Immunity. 79: 1407-17. PMID 21245275 DOI: 10.1128/IAI.01126-10  1
2010 Green AM, Mattila JT, Bigbee CL, Bongers KS, Lin PL, Flynn JL. CD4(+) regulatory T cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection. The Journal of Infectious Diseases. 202: 533-41. PMID 20617900 DOI: 10.1086/654896  1
2010 Lin PL, Flynn JL. Understanding latent tuberculosis: a moving target. Journal of Immunology (Baltimore, Md. : 1950). 185: 15-22. PMID 20562268 DOI: 10.4049/jimmunol.0903856  0.32
2010 Russell DG, Barry CE, Flynn JL. Tuberculosis: what we don't know can, and does, hurt us. Science (New York, N.Y.). 328: 852-6. PMID 20466922 DOI: 10.1126/science.1184784  1
2010 Scanga CA, Flynn JL. Mycobacterial infections and the inflammatory seesaw. Cell Host & Microbe. 7: 177-9. PMID 20227659 DOI: 10.1016/j.chom.2010.03.003  1
2010 Diedrich CR, Mattila JT, Klein E, Janssen C, Phuah J, Sturgeon TJ, Montelaro RC, Lin PL, Flynn JL. Reactivation of latent tuberculosis in cynomolgus macaques infected with SIV is associated with early peripheral T cell depletion and not virus load. Plos One. 5: e9611. PMID 20224771 DOI: 10.1371/journal.pone.0009611  1
2010 Lin PL, Myers A, Smith L, Bigbee C, Bigbee M, Fuhrman C, Grieser H, Chiosea I, Voitenek NN, Capuano SV, Klein E, Flynn JL. Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model. Arthritis and Rheumatism. 62: 340-50. PMID 20112395 DOI: 10.1002/art.27271  0.32
2009 Einarsdottir T, Lockhart E, Flynn JL. Cytotoxicity and secretion of gamma interferon are carried out by distinct CD8 T cells during Mycobacterium tuberculosis infection. Infection and Immunity. 77: 4621-30. PMID 19667047 DOI: 10.1128/IAI.00415-09  1
2009 Lin PL, Rodgers M, Smith L, Bigbee M, Myers A, Bigbee C, Chiosea I, Capuano SV, Fuhrman C, Klein E, Flynn JL. Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model. Infection and Immunity. 77: 4631-42. PMID 19620341 DOI: 10.1128/IAI.00592-09  0.32
2009 Windish HP, Lin PL, Mattila JT, Green AM, Onuoha EO, Kane LP, Flynn JL. Aberrant TGF-beta signaling reduces T regulatory cells in ICAM-1-deficient mice, increasing the inflammatory response to Mycobacterium tuberculosis. Journal of Leukocyte Biology. 86: 713-25. PMID 19454651 DOI: 10.1189/jlb.1208740  1
2009 Ray JC, Flynn JL, Kirschner DE. Synergy between individual TNF-dependent functions determines granuloma performance for controlling Mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 182: 3706-17. PMID 19265149 DOI: 10.4049/jimmunol.0802297  1
2008 Pawar SN, Mattila JT, Sturgeon TJ, Lin PL, Narayan O, Montelaro RC, Flynn JL. Comparison of the effects of pathogenic simian human immunodeficiency virus strains SHIV-89.6P and SHIV-KU2 in cynomolgus macaques. Aids Research and Human Retroviruses. 24: 643-54. PMID 18366326 DOI: 10.1089/aid.2007.0238  1
2008 Via LE, Lin PL, Ray SM, Carrillo J, Allen SS, Eum SY, Taylor K, Klein E, Manjunatha U, Gonzales J, Lee EG, Park SK, Raleigh JA, Cho SN, McMurray DN, ... Flynn JL, et al. Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates. Infection and Immunity. 76: 2333-40. PMID 18347040 DOI: 10.1128/IAI.01515-07  1
2008 Lerche NW, Yee JL, Capuano SV, Flynn JL. New approaches to tuberculosis surveillance in nonhuman primates. Ilar Journal / National Research Council, Institute of Laboratory Animal Resources. 49: 170-8. PMID 18323579  1
2008 Khan IH, Ravindran R, Yee J, Ziman M, Lewinsohn DM, Gennaro ML, Flynn JL, Goulding CW, DeRiemer K, Lerche NW, Luciw PA. Profiling antibodies to Mycobacterium tuberculosis by multiplex microbead suspension arrays for serodiagnosis of tuberculosis. Clinical and Vaccine Immunology : Cvi. 15: 433-8. PMID 18077619 DOI: 10.1128/CVI.00354-07  1
2007 Marino S, Sud D, Plessner H, Lin PL, Chan J, Flynn JL, Kirschner DE. Differences in reactivation of tuberculosis induced from anti-TNF treatments are based on bioavailability in granulomatous tissue. Plos Computational Biology. 3: 1909-24. PMID 17953477 DOI: 10.1371/journal.pcbi.0030194  1
2007 Pegu A, Flynn JL, Reinhart TA. Afferent and efferent interfaces of lymph nodes are distinguished by expression of lymphatic endothelial markers and chemokines. Lymphatic Research and Biology. 5: 91-103. PMID 17935477 DOI: 10.1089/lrb.2007.1006  1
2007 Dann FJ, Gottlieb AB, Deepe GS, Flynn JL, Wallis RS, Thompson EH, Louie JS. Structural-functional relationships of TNF-alpha antagonists: next steps. The Journal of Investigative Dermatology. Symposium Proceedings / the Society For Investigative Dermatology, Inc. [and] European Society For Dermatological Research. 12: 46-7. PMID 17502869 DOI: 10.1038/sj.jidsymp.5650028  1
2007 Lin PL, Plessner HL, Voitenok NN, Flynn JL. Tumor necrosis factor and tuberculosis. The Journal of Investigative Dermatology. Symposium Proceedings / the Society For Investigative Dermatology, Inc. [and] European Society For Dermatological Research. 12: 22-5. PMID 17502865 DOI: 10.1038/sj.jidsymp.5650027  0.32
2007 Plessner HL, Lin PL, Kohno T, Louie JS, Kirschner D, Chan J, Flynn JL. Neutralization of tumor necrosis factor (TNF) by antibody but not TNF receptor fusion molecule exacerbates chronic murine tuberculosis. The Journal of Infectious Diseases. 195: 1643-50. PMID 17471434 DOI: 10.1086/517519  1
2006 Morel PA, Ta'asan S, Morel BF, Kirschner DE, Flynn JL. New insights into mathematical modeling of the immune system. Immunologic Research. 36: 157-65. PMID 17337776 DOI: 10.1385/IR:36:1:157  1
2006 Lockhart E, Green AM, Flynn JL. IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 177: 4662-9. PMID 16982905  0.48
2006 Lin PL, Pawar S, Myers A, Pegu A, Fuhrman C, Reinhart TA, Capuano SV, Klein E, Flynn JL. Early events in Mycobacterium tuberculosis infection in cynomolgus macaques. Infection and Immunity. 74: 3790-803. PMID 16790751 DOI: 10.1128/IAI.00064-06  1
2005 Lazarevic V, Nolt D, Flynn JL. Long-term control of Mycobacterium tuberculosis infection is mediated by dynamic immune responses. Journal of Immunology (Baltimore, Md. : 1950). 175: 1107-17. PMID 16002712  1
2005 Algood HM, Lin PL, Flynn JL. Tumor necrosis factor and chemokine interactions in the formation and maintenance of granulomas in tuberculosis. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 41: S189-93. PMID 15983898 DOI: 10.1086/429994  0.32
2005 Myers AJ, Eilertson B, Fulton SA, Flynn JL, Canaday DH. The purinergic P2X7 receptor is not required for control of pulmonary Mycobacterium tuberculosis infection. Infection and Immunity. 73: 3192-5. PMID 15845532 DOI: 10.1128/IAI.73.5.3192-3195.2005  1
2005 Lazarevic V, Yankura DJ, DiVito SJ, Flynn JL. Induction of Mycobacterium tuberculosis-specific primary and secondary T-cell responses in interleukin-15-deficient mice. Infection and Immunity. 73: 2910-22. PMID 15845497 DOI: 10.1128/IAI.73.5.2910-2922.2005  1
2005 Flynn JL, Chan J. What's good for the host is good for the bug. Trends in Microbiology. 13: 98-102. PMID 15737727 DOI: 10.1016/j.tim.2005.01.005  1
2004 Marino S, Pawar S, Fuller CL, Reinhart TA, Flynn JL, Kirschner DE. Dendritic cell trafficking and antigen presentation in the human immune response to Mycobacterium tuberculosis. Journal of Immunology (Baltimore, Md. : 1950). 173: 494-506. PMID 15210810  1
2004 Algood HM, Lin PL, Yankura D, Jones A, Chan J, Flynn JL. TNF influences chemokine expression of macrophages in vitro and that of CD11b+ cells in vivo during Mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 172: 6846-57. PMID 15153503  1
2004 Nolt D, Flynn JL. Interleukin-12 therapy reduces the number of immune cells and pathology in lungs of mice infected with Mycobacterium tuberculosis. Infection and Immunity. 72: 2976-88. PMID 15102810  0.56
2003 Lazarevic V, Myers AJ, Scanga CA, Flynn JL. CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infection. Immunity. 19: 823-35. PMID 14670300 DOI: 10.1016/S1074-7613(03)00324-8  1
2003 Fuller CL, Flynn JL, Reinhart TA. In situ study of abundant expression of proinflammatory chemokines and cytokines in pulmonary granulomas that develop in cynomolgus macaques experimentally infected with Mycobacterium tuberculosis. Infection and Immunity. 71: 7023-34. PMID 14638792 DOI: 10.1128/IAI.71.12.7023-7034.2003  1
2003 Algood HM, Chan J, Flynn JL. Chemokines and tuberculosis. Cytokine & Growth Factor Reviews. 14: 467-77. PMID 14563349 DOI: 10.1016/S1359-6101(03)00054-6  1
2003 Capuano SV, Croix DA, Pawar S, Zinovik A, Myers A, Lin PL, Bissel S, Fuhrman C, Klein E, Flynn JL. Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection Infection and Immunity. 71: 5831-5844. PMID 14500505 DOI: 10.1128/IAI.71.10.5831-5844.2003  1
2003 Tufariello JM, Chan J, Flynn JL. Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection. The Lancet. Infectious Diseases. 3: 578-90. PMID 12954564 DOI: 10.1016/S1473-3099(03)00741-2  1
2003 Flynn JL, Chan J. Immune evasion by Mycobacterium tuberculosis: living with the enemy. Current Opinion in Immunology. 15: 450-5. PMID 12900278 DOI: 10.1016/S0952-7915(03)00075-X  1
2003 Board KF, Patil S, Lebedeva I, Capuano S, Trichel AM, Murphey-Corb M, Rajakumar PA, Flynn JL, Haidaris CG, Norris KA. Experimental Pneumocystis carinii pneumonia in simian immunodeficiency virus-infected rhesus macaques. The Journal of Infectious Diseases. 187: 576-88. PMID 12599074 DOI: 10.1086/373997  1
2002 Scott HM, Flynn JL. Mycobacterium tuberculosis in chemokine receptor 2-deficient mice: influence of dose on disease progression. Infection and Immunity. 70: 5946-54. PMID 12379669 DOI: 10.1128/IAI.70.11.5946-5954.2002  1
2002 Croix DA, Board K, Capuano S, Murphey-Corb M, Haidaris CG, Flynn JL, Reinhart T, Norris KA. Alterations in T lymphocyte profiles of bronchoalveolar lavage fluid from SIV- and Pneumocystis carinii-coinfected rhesus macaques. Aids Research and Human Retroviruses. 18: 391-401. PMID 11897041 DOI: 10.1089/088922202753519179  1
2001 Serbina NV, Lazarevic V, Flynn JL. CD4(+) T cells are required for the development of cytotoxic CD8(+) T cells during Mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 167: 6991-7000. PMID 11739519  1
2001 Scanga CA, Mohan VP, Tanaka K, Alland D, Flynn JL, Chan J. The inducible nitric oxide synthase locus confers protection against aerogenic challenge of both clinical and laboratory strains of Mycobacterium tuberculosis in mice. Infection and Immunity. 69: 7711-7. PMID 11705952 DOI: 10.1128/IAI.69.12.7711-7717.2001  1
2001 Peters W, Scott HM, Chambers HF, Flynn JL, Charo IF, Ernst JD. Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 98: 7958-63. PMID 11438742 DOI: 10.1073/pnas.131207398  1
2001 Serbina NV, Flynn JL. CD8(+) T cells participate in the memory immune response to Mycobacterium tuberculosis. Infection and Immunity. 69: 4320-8. PMID 11401969 DOI: 10.1128/IAI.69.7.4320-4328.2001  1
2001 Chun T, Serbina NV, Nolt D, Wang B, Chiu NM, Flynn JL, Wang CR. Induction of M3-restricted cytotoxic T lymphocyte responses by N-formylated peptides derived from Mycobacterium tuberculosis. The Journal of Experimental Medicine. 193: 1213-20. PMID 11369792 DOI: 10.1084/jem.193.10.1213  1
2001 Mohan VP, Scanga CA, Yu K, Scott HM, Tanaka KE, Tsang E, Tsai MM, Flynn JL, Chan J. Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology. Infection and Immunity. 69: 1847-55. PMID 11179363 DOI: 10.1128/IAI.69.3.1847-1855.2001  1
2001 Bodnar KA, Serbina NV, Flynn JL. Fate of Mycobacterium tuberculosis within murine dendritic cells. Infection and Immunity. 69: 800-9. PMID 11159971 DOI: 10.1128/IAI.69.2.800-809.2001  1
2000 Scanga CA, Mohan VP, Yu K, Joseph H, Tanaka K, Chan J, Flynn JL. Depletion of CD4(+) T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon gamma and nitric oxide synthase 2. The Journal of Experimental Medicine. 192: 347-58. PMID 10934223 DOI: 10.1084/jem.192.3.347  1
2000 Serbina NV, Liu CC, Scanga CA, Flynn JL. CD8+ CTL from lungs of Mycobacterium tuberculosis-infected mice express perforin in vivo and lyse infected macrophages. Journal of Immunology (Baltimore, Md. : 1950). 165: 353-63. PMID 10861072  1
1999 Scanga CA, Mohan VP, Joseph H, Yu K, Chan J, Flynn JL. Reactivation of latent tuberculosis: variations on the Cornell murine model. Infection and Immunity. 67: 4531-8. PMID 10456896  1
1999 Serbina NV, Flynn JL. Early emergence of CD8(+) T cells primed for production of type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected mice. Infection and Immunity. 67: 3980-8. PMID 10417164  1
1998 Flynn JL, Scanga CA, Tanaka KE, Chan J. Effects of aminoguanidine on latent murine tuberculosis. Journal of Immunology (Baltimore, Md. : 1950). 160: 1796-803. PMID 9469439  1
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