| Year |
Citation |
Score |
| 2021 |
Bliska JB, Brodsky IE, Mecsas J. Role of the Yersinia pseudotuberculosis Virulence Plasmid in Pathogen-Phagocyte Interactions in Mesenteric Lymph Nodes. Ecosal Plus. 9: eESP00142021. PMID 34910573 DOI: 10.1128/ecosalplus.ESP-0014-2021 |
0.426 |
|
| 2021 |
Nguyen GT, Xu S, Adams W, Leong JM, Bunnell SC, Mansour MK, Sykes DB, Mecsas J. Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and stimulation. Iscience. 24: 102871. PMID 34386732 DOI: 10.1016/j.isci.2021.102871 |
0.357 |
|
| 2020 |
Moir DT, Bowlin NO, Berube BJ, Yabut J, Mills DM, Nguyen GT, Aron ZD, Williams JD, Mecsas J, Hauser AR, Bowlin TL. A Structure-Function-Inhibition Analysis of the Type III Secretion Needle Protein PscF. Journal of Bacteriology. PMID 32601072 DOI: 10.1128/Jb.00055-20 |
0.446 |
|
| 2020 |
Shaban L, Nguyen GT, Mecsas-Faxon BD, Swanson KD, Tan S, Mecsas J. Yersinia pseudotuberculosis YopH targets SKAP2-dependent and independent signaling pathways to block neutrophil antimicrobial mechanisms during infection. Plos Pathogens. 16: e1008576. PMID 32392230 DOI: 10.1371/Journal.Ppat.1008576 |
0.446 |
|
| 2020 |
Nguyen GT, Shaban L, Mack M, Swanson KD, Bunnell SC, Sykes DB, Mecsas J. SKAP2 is required for defense against infection and neutrophil respiratory burst. Elife. 9. PMID 32352382 DOI: 10.7554/Elife.56656 |
0.503 |
|
| 2020 |
Paczosa MK, Silver RJ, McCabe AL, Tai AK, McLeish CH, Lazinski DW, Mecsas J. Transposon mutagenesis screen of identifies multiple genes important for resisting antimicrobial activities of neutrophils in mice. Infection and Immunity. PMID 31988174 DOI: 10.1128/Iai.00034-20 |
0.434 |
|
| 2020 |
Nguyen GT, Shaban L, Mack M, Swanson KD, Bunnell SC, Sykes DB, Mecsas J. Author response: SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst Elife. DOI: 10.7554/Elife.56656.Sa2 |
0.361 |
|
| 2019 |
Fasciano AC, Blutt SE, Estes MK, Mecsas J. Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers. Journal of Visualized Experiments : Jove. PMID 31403623 DOI: 10.3791/59894 |
0.343 |
|
| 2019 |
Mecsas J. Unraveling neutrophil- interactions during tissue infection. F1000research. 8. PMID 31327994 DOI: 10.12688/F1000Research.18940.1 |
0.519 |
|
| 2019 |
Nguyen GT, McCabe AL, Fasciano AC, Mecsas J. Detection of Cells Translocated with Yersinia Yops in Infected Tissues Using β-Lactamase Fusions. Methods in Molecular Biology (Clifton, N.J.). 2010: 117-139. PMID 31177435 DOI: 10.1007/978-1-4939-9541-7_9 |
0.505 |
|
| 2019 |
Silver RJ, Paczosa MK, McCabe AL, Balada-Llasat JM, Baleja JD, Mecsas J. Amino acid biosynthetic pathways are required for growth in immunocompromised lungs and are druggable targets during infection. Antimicrobial Agents and Chemotherapy. PMID 31109974 DOI: 10.1128/Aac.02674-18 |
0.406 |
|
| 2019 |
Fasciano AC, Mecsas J, Isberg RR. New Age Strategies To Reconstruct Mucosal Tissue Colonization and Growth in Cell Culture Systems. Microbiology Spectrum. 7. PMID 30848233 DOI: 10.1128/Microbiolspec.Bai-0013-2019 |
0.371 |
|
| 2018 |
Markey L, Shaban L, Green ER, Lemon KP, Mecsas J, Kumamoto CA. Pre-colonization with the commensal fungus Candida albicans reduces murine susceptibility to Clostridium difficile infection. Gut Microbes. 0. PMID 29667487 DOI: 10.1080/19490976.2018.1465158 |
0.411 |
|
| 2018 |
Buchrieser C, Mecsas J. Editorial overview: Host-pathogen interactions shaped through evolutionary and regulatory processes. Current Opinion in Microbiology. 41: v-viii. PMID 29559085 DOI: 10.1016/J.Mib.2018.02.001 |
0.336 |
|
| 2018 |
Shaban L, Chen Y, Fasciano AC, Lin Y, Kaplan DL, Kumamoto CA, Mecsas J. A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage. Anaerobe. PMID 29462695 DOI: 10.1016/J.Anaerobe.2018.02.006 |
0.326 |
|
| 2017 |
Nguyen GT, Green ER, Mecsas J. Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance. Frontiers in Cellular and Infection Microbiology. 7: 373. PMID 28890882 DOI: 10.3389/Fcimb.2017.00373 |
0.478 |
|
| 2017 |
Saleh D, Najjar M, Zelic M, Shah S, Nogusa S, Polykratis A, Paczosa MK, Gough PJ, Bertin J, Whalen M, Fitzgerald KA, Slavov N, Pasparakis M, Balachandran S, Kelliher M, ... Mecsas J, et al. Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide. Journal of Immunology (Baltimore, Md. : 1950). PMID 28461567 DOI: 10.4049/Jimmunol.1601717 |
0.388 |
|
| 2016 |
Ratner D, Orning MP, Proulx MK, Wang D, Gavrilin MA, Wewers MD, Alnemri ES, Johnson PF, Lee B, Mecsas J, Kayagaki N, Goguen JD, Lien E. The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation. Plos Pathogens. 12: e1006035. PMID 27911947 DOI: 10.1371/Journal.Ppat.1006035 |
0.354 |
|
| 2016 |
Green ER, Clark S, Crimmins GT, Mack M, Kumamoto CA, Mecsas J. Fis Is Essential for Yersinia pseudotuberculosis Virulence and Protects against Reactive Oxygen Species Produced by Phagocytic Cells during Infection. Plos Pathogens. 12: e1005898. PMID 27689357 DOI: 10.1371/Journal.Ppat.1005898 |
0.537 |
|
| 2016 |
Anantharajah A, Faure E, Buyck JM, Sundin C, Lindmark T, Mecsas J, Yahr TL, Tulkens PM, Mingeot-Leclercq MP, Guery B, Van Bambeke F. Inhibition of the injectisome and flagellar type III secretion systems by INP1855 impairs Pseudomonas aeruginosa pathogenicity and inflammasome activation. The Journal of Infectious Diseases. PMID 27412581 DOI: 10.1093/Infdis/Jiw295 |
0.496 |
|
| 2016 |
Paczosa MK, Mecsas J. Klebsiella pneumoniae: Going on the Offense with a Strong Defense. Microbiology and Molecular Biology Reviews : Mmbr. 80: 629-61. PMID 27307579 DOI: 10.1128/Mmbr.00078-15 |
0.453 |
|
| 2016 |
Hauser AR, Mecsas J, Moir DT. Beyond Antibiotics: New Therapeutic Approaches For Bacterial Infections. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 27025826 DOI: 10.1093/Cid/Ciw200 |
0.406 |
|
| 2016 |
Green ER, Mecsas J. Bacterial Secretion Systems: An Overview. Microbiology Spectrum. 4. PMID 26999395 DOI: 10.1128/Microbiolspec.Vmbf-0012-2015 |
0.402 |
|
| 2015 |
Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Philip NH, Brodsky IE, Mecsas J, Kagan JC. A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4. Cell Host & Microbe. 18: 682-93. PMID 26651944 DOI: 10.1016/J.Chom.2015.11.006 |
0.459 |
|
| 2015 |
Chen Y, Lin Y, Davis KM, Wang Q, Rnjak-Kovacina J, Li C, Isberg RR, Kumamoto CA, Mecsas J, Kaplan DL. Robust bioengineered 3D functional human intestinal epithelium. Scientific Reports. 5: 13708. PMID 26374193 DOI: 10.1038/Srep13708 |
0.322 |
|
| 2015 |
Yang Y, Millán JL, Mecsas J, Guillemin K. Intestinal alkaline phosphatase deficiency leads to lipopolysaccharide desensitization and faster weight gain. Infection and Immunity. 83: 247-58. PMID 25348635 DOI: 10.1128/Iai.02520-14 |
0.358 |
|
| 2014 |
Bowlin NO, Williams JD, Knoten CA, Torhan MC, Tashjian TF, Li B, Aiello D, Mecsas J, Hauser AR, Peet NP, Bowlin TL, Moir DT. Mutations in the Pseudomonas aeruginosa needle protein gene pscF confer resistance to phenoxyacetamide inhibitors of the type III secretion system. Antimicrobial Agents and Chemotherapy. 58: 2211-20. PMID 24468789 DOI: 10.1128/Aac.02795-13 |
0.452 |
|
| 2014 |
Paczosa MK, Fisher ML, Maldonado-Arocho FJ, Mecsas J. Yersinia pseudotuberculosis uses Ail and YadA to circumvent neutrophils by directing Yop translocation during lung infection. Cellular Microbiology. 16: 247-68. PMID 24119087 DOI: 10.1111/Cmi.12219 |
0.403 |
|
| 2013 |
Rolán HG, Durand EA, Mecsas J. Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection. Cell Host & Microbe. 14: 306-17. PMID 24034616 DOI: 10.1016/J.Chom.2013.08.013 |
0.748 |
|
| 2013 |
Maldonado-Arocho FJ, Green C, Fisher ML, Paczosa MK, Mecsas J. Adhesins and host serum factors drive Yop translocation by yersinia into professional phagocytes during animal infection. Plos Pathogens. 9: e1003415. PMID 23818844 DOI: 10.1371/Journal.Ppat.1003415 |
0.576 |
|
| 2013 |
Harmon DE, Murphy JL, Davis AJ, Mecsas J. A mutant with aberrant extracellular LcrV-YscF interactions fails to form pores and translocate Yop effector proteins but retains the ability to trigger Yop secretion in response to host cell contact. Journal of Bacteriology. 195: 2244-54. PMID 23475976 DOI: 10.1128/Jb.02011-12 |
0.757 |
|
| 2012 |
Crimmins GT, Mohammadi S, Green ER, Bergman MA, Isberg RR, Mecsas J. Identification of MrtAB, an ABC transporter specifically required for Yersinia pseudotuberculosis to colonize the mesenteric lymph nodes. Plos Pathogens. 8: e1002828. PMID 22876175 DOI: 10.1371/Journal.Ppat.1002828 |
0.428 |
|
| 2012 |
Lister IM, Raftery C, Mecsas J, Levy SB. Yersinia pestis AcrAB-TolC in antibiotic resistance and virulence. Antimicrobial Agents and Chemotherapy. 56: 1120-3. PMID 22083483 DOI: 10.1128/Aac.05338-11 |
0.343 |
|
| 2010 |
Garrity-Ryan LK, Kim OK, Balada-Llasat JM, Bartlett VJ, Verma AK, Fisher ML, Castillo C, Songsungthong W, Tanaka SK, Levy SB, Mecsas J, Alekshun MN. Small molecule inhibitors of LcrF, a Yersinia pseudotuberculosis transcription factor, attenuate virulence and limit infection in a murine pneumonia model. Infection and Immunity. 78: 4683-90. PMID 20823209 DOI: 10.1128/Iai.01305-09 |
0.763 |
|
| 2010 |
Harmon DE, Davis AJ, Castillo C, Mecsas J. Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis. Antimicrobial Agents and Chemotherapy. 54: 3241-54. PMID 20498321 DOI: 10.1128/Aac.00364-10 |
0.765 |
|
| 2010 |
McCoy MW, Marré ML, Lesser CF, Mecsas J. The C-terminal tail of Yersinia pseudotuberculosis YopM is critical for interacting with RSK1 and for virulence. Infection and Immunity. 78: 2584-98. PMID 20368345 DOI: 10.1128/Iai.00141-10 |
0.531 |
|
| 2010 |
Davis AJ, Díaz DA, Mecsas J. A dominant-negative needle mutant blocks type III secretion of early but not late substrates in Yersinia. Molecular Microbiology. 76: 236-59. PMID 20199604 DOI: 10.1111/J.1365-2958.2010.07096.X |
0.378 |
|
| 2010 |
Songsungthong W, Higgins MC, Rolán HG, Murphy JL, Mecsas J. ROS-inhibitory activity of YopE is required for full virulence of Yersinia in mice. Cellular Microbiology. 12: 988-1001. PMID 20148901 DOI: 10.1111/J.1462-5822.2010.01448.X |
0.759 |
|
| 2010 |
Durand EA, Maldonado-Arocho FJ, Castillo C, Walsh RL, Mecsas J. The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infection. Cellular Microbiology. 12: 1064-82. PMID 20148898 DOI: 10.1111/J.1462-5822.2010.01451.X |
0.758 |
|
| 2010 |
Lister IM, Mecsas J, Levy SB. Effect of MarA-like proteins on antibiotic resistance and virulence in Yersinia pestis. Infection and Immunity. 78: 364-71. PMID 19841071 DOI: 10.1128/Iai.00904-09 |
0.385 |
|
| 2009 |
Bergman MA, Loomis WP, Mecsas J, Starnbach MN, Isberg RR. CD8(+) T cells restrict Yersinia pseudotuberculosis infection: bypass of anti-phagocytosis by targeting antigen-presenting cells. Plos Pathogens. 5: e1000573. PMID 19730693 DOI: 10.1371/Journal.Ppat.1000573 |
0.474 |
|
| 2009 |
Ren Z, Gay R, Thomas A, Pae M, Wu D, Logsdon L, Mecsas J, Meydani SN. Effect of age on susceptibility to Salmonella Typhimurium infection in C57BL/6 mice. Journal of Medical Microbiology. 58: 1559-67. PMID 19729455 DOI: 10.1099/Jmm.0.013250-0 |
0.372 |
|
| 2007 |
White SJ, Rosenbach A, Lephart P, Nguyen D, Benjamin A, Tzipori S, Whiteway M, Mecsas J, Kumamoto CA. Self-regulation of Candida albicans population size during GI colonization. Plos Pathogens. 3: e184. PMID 18069889 DOI: 10.1371/Journal.Ppat.0030184 |
0.407 |
|
| 2007 |
Balada-Llasat JM, Panilaitis B, Kaplan D, Mecsas J. Oral inoculation with Type III secretion mutants of Yersinia pseudotuberculosis provides protection from oral, intraperitoneal, or intranasal challenge with virulent Yersinia. Vaccine. 25: 1526-33. PMID 17194509 DOI: 10.1016/J.Vaccine.2006.10.016 |
0.414 |
|
| 2007 |
Fisher ML, Castillo C, Mecsas J. Intranasal inoculation of mice with Yersinia pseudotuberculosis causes a lethal lung infection that is dependent on Yersinia outer proteins and PhoP. Infection and Immunity. 75: 429-42. PMID 17074849 DOI: 10.1128/Iai.01287-06 |
0.398 |
|
| 2007 |
Davis AJ, Mecsas J. Mutations in the Yersinia pseudotuberculosis type III secretion system needle protein, YscF, that specifically abrogate effector translocation into host cells. Journal of Bacteriology. 189: 83-97. PMID 17071752 DOI: 10.1128/Jb.01396-06 |
0.428 |
|
| 2006 |
Balada-Llasat JM, Mecsas J. Yersinia has a tropism for B and T cell zones of lymph nodes that is independent of the type III secretion system. Plos Pathogens. 2: e86. PMID 16948531 DOI: 10.1371/Journal.Ppat.0020086 |
0.459 |
|
| 2006 |
Logsdon LK, Mecsas J. A non-invasive quantitative assay to measure murine intestinal inflammation using the neutrophil marker lactoferrin. Journal of Immunological Methods. 313: 183-90. PMID 16806255 DOI: 10.1016/J.Jim.2006.05.001 |
0.333 |
|
| 2006 |
Barnes PD, Bergman MA, Mecsas J, Isberg RR. Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine. The Journal of Experimental Medicine. 203: 1591-601. PMID 16754724 DOI: 10.1084/Jem.20060905 |
0.349 |
|
| 2006 |
Logsdon LK, Mecsas J. The proinflammatory response induced by wild-type Yersinia pseudotuberculosis infection inhibits survival of yop mutants in the gastrointestinal tract and Peyer's patches. Infection and Immunity. 74: 1516-27. PMID 16495522 DOI: 10.1128/Iai.74.3.1516-1527.2006 |
0.51 |
|
| 2004 |
Mecsas J, Franklin G, Kuziel WA, Brubaker RR, Falkow S, Mosier DE. Evolutionary genetics: CCR5 mutation and plague protection. Nature. 427: 606. PMID 14961112 DOI: 10.1038/427606A |
0.375 |
|
| 2003 |
Logsdon LK, Mecsas J. Requirement of the Yersinia pseudotuberculosis effectors YopH and YopE in colonization and persistence in intestinal and lymph tissues. Infection and Immunity. 71: 4595-607. PMID 12874339 DOI: 10.1128/Iai.71.8.4595-4607.2003 |
0.451 |
|
| 2002 |
Mecsas J. Use of signature-tagged mutagenesis in pathogenesis studies. Current Opinion in Microbiology. 5: 33-7. PMID 11834366 DOI: 10.1016/S1369-5274(02)00282-5 |
0.445 |
|
| 2001 |
Mecsas J, Bilis I, Falkow S. Identification of attenuated Yersinia pseudotuberculosis strains and characterization of an orogastric infection in BALB/c mice on day 5 postinfection by signature-tagged mutagenesis. Infection and Immunity. 69: 2779-87. PMID 11292689 DOI: 10.1128/Iai.67.5.2779-2787.2001 |
0.489 |
|
| 1999 |
Yao T, Mecsas J, Healy JI, Falkow S, Chien Y. Suppression of T and B lymphocyte activation by a Yersinia pseudotuberculosis virulence factor, yopH. The Journal of Experimental Medicine. 190: 1343-50. PMID 10544205 DOI: 10.1084/Jem.190.9.1343 |
0.437 |
|
| 1999 |
Raupach B, Mecsas J, Heczko U, Falkow S, Finlay BB. Bacterial epithelial cell cross talk. Current Topics in Microbiology and Immunology. 236: 137-61. PMID 9893359 DOI: 10.1007/978-3-642-59951-4_8 |
0.449 |
|
| 1998 |
Monack DM, Mecsas J, Bouley D, Falkow S. Yersinia-induced apoptosis in vivo aids in the establishment of a systemic infection of mice. The Journal of Experimental Medicine. 188: 2127-37. PMID 9841926 DOI: 10.1084/Jem.188.11.2127 |
0.506 |
|
| 1998 |
Mecsas J, Raupach B, Falkow S. The Yersinia Yops inhibit invasion of Listeria, Shigella and Edwardsiella but not Salmonella into epithelial cells. Molecular Microbiology. 28: 1269-81. PMID 9680215 DOI: 10.1046/J.1365-2958.1998.00891.X |
0.499 |
|
| 1997 |
Monack DM, Mecsas J, Ghori N, Falkow S. Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death. Proceedings of the National Academy of Sciences of the United States of America. 94: 10385-90. PMID 9294220 DOI: 10.1073/Pnas.94.19.10385 |
0.492 |
|
| 1996 |
Mecsas J, Strauss EJ. Molecular Mechanisms of Bacterial Virulence: Type III Secretion and Pathogenicity Islands Emerging Infectious Diseases. 2: 270-288. PMID 8969244 DOI: 10.3201/Eid0204.960403 |
0.465 |
|
| 1995 |
Mecsas J, Welch R, Erickson JW, Gross CA. Identification and characterization of an outer membrane protein, OmpX, in Escherichia coli that is homologous to a family of outer membrane proteins including Ail of Yersinia enterocolitica Journal of Bacteriology. 177: 799-804. PMID 7836315 DOI: 10.1128/Jb.177.3.799-804.1995 |
0.367 |
|
| 1993 |
Mecsas J, Rouviere PE, Erickson JW, Donohue TJ, Gross CA. The activity of σE, an Escherichia coli heat-inducible σ-factor, is modulated by expression of outer membrane proteins Genes and Development. 7: 2618-2628. PMID 8276244 DOI: 10.1101/Gad.7.12B.2618 |
0.336 |
|
| 1987 |
Mecsas J, Sugden B. Replication of plasmids derived from bovine papilloma virus type 1 and Epstein-Barr virus in cells in culture Annual Review of Cell Biology. 3: 87-108. PMID 2825737 DOI: 10.1146/Annurev.Cb.03.110187.000511 |
0.322 |
|
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