Eric J. Rubin - Publications

Harvard University, Cambridge, MA, United States 
Microbiology Biology

131 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Fishbein SRS, Tomasi FG, Wolf ID, Dulberger CL, Wang A, Keshishian H, Wallace L, Carr SA, Ioerger TR, Rego EH, Rubin EJ. The conserved translation factor LepA is required for optimal synthesis of a porin family in . Journal of Bacteriology. PMID 33361193 DOI: 10.1128/JB.00604-20  0.56
2020 Kester JC, Kandror O, Akopian T, Chase MR, Zhu J, Rubin EJ, Goldberg AL, Fortune SM. ClpX is Essential and Activated by Single Strand DNA Binding Protein in Mycobacteria. Journal of Bacteriology. PMID 33229461 DOI: 10.1128/JB.00608-20  0.76
2020 Bloom BR, Farmer PE, Rubin EJ. WHO's Next - The United States and the World Health Organization. The New England Journal of Medicine. PMID 32668104 DOI: 10.1056/NEJMe2024894  0.32
2020 Gopal P, Sarathy JP, Yee M, Ragunathan P, Shin J, Bhushan S, Zhu J, Akopian T, Kandror O, Lim TK, Gengenbacher M, Lin Q, Rubin EJ, Grüber G, Dick T. Pyrazinamide triggers degradation of its target aspartate decarboxylase. Nature Communications. 11: 1661. PMID 32245967 DOI: 10.1038/s41467-020-15516-1  0.32
2019 Dragset MS, Ioerger TR, Loevenich M, Haug M, Sivakumar N, Marstad A, Cardona PJ, Klinkenberg G, Rubin EJ, Steigedal M, Flo TH. Global Assessment of Mycobacterium avium subsp. Genetic Requirement for Growth and Virulence. Msystems. 4. PMID 31822597 DOI: 10.1128/mSystems.00402-19  0.4
2019 Dulberger CL, Rubin EJ, Boutte CC. The mycobacterial cell envelope - a moving target. Nature Reviews. Microbiology. PMID 31728063 DOI: 10.1038/S41579-019-0273-7  0.52
2019 Ruetz M, Campanello GC, Purchal M, Shen H, McDevitt L, Gouda H, Wakabayashi S, Zhu J, Rubin EJ, Warncke K, Mootha VK, Koutmos M, Banerjee R. Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair. Science (New York, N.Y.). 366: 589-593. PMID 31672889 DOI: 10.1126/Science.Aay0934  0.32
2019 Poce G, Consalvi S, Venditti G, Alfonso S, Desideri N, Fernandez-Menendez R, Bates RH, Ballell L, Barros Aguirre D, Rullas J, De Logu A, Gardner M, Ioerger TR, Rubin EJ, Biava M. Novel Pyrazole-Containing Compounds Active against . Acs Medicinal Chemistry Letters. 10: 1423-1429. PMID 31620228 DOI: 10.1021/Acsmedchemlett.9B00204  0.4
2019 Dragset MS, Ioerger TR, Zhang YJ, Mærk M, Ginbot Z, Sacchettini JC, Flo TH, Rubin EJ, Steigedal M. Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness. Scientific Reports. 9: 11394. PMID 31388080 DOI: 10.1038/S41598-019-47905-Y  0.8
2019 Mir M, Prisic S, Kang CM, Lun S, Guo H, Murry JP, Rubin EJ, Husson RN. Correction for Mir et al., "Mycobacterial Gene Is Required for Optimal Nutrient Utilization and Virulence". Infection and Immunity. 87. PMID 31337689 DOI: 10.1128/Iai.00414-19  0.56
2019 Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, ... ... Rubin EJ, et al. Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes. Nature. PMID 31217586 DOI: 10.1038/s41586-019-1315-z  0.8
2019 Wu KJ, Boutte CC, Ioerger TR, Rubin EJ. Mycobacterium smegmatis HtrA Blocks the Toxic Activity of a Putative Cell Wall Amidase. Cell Reports. 27: 2468-2479.e3. PMID 31116989 DOI: 10.1016/J.Celrep.2018.12.063  0.52
2019 Baranowski C, Rego EH, Rubin EJ. The Dream of a Mycobacterium. Microbiology Spectrum. 7. PMID 31025625 DOI: 10.1128/microbiolspec.GPP3-0008-2018  0.56
2019 Gustine JN, Au MB, Haserick JR, Hett EC, Rubin EJ, Gibson FC, Deng LL. Cell Wall Hydrolytic Enzymes Enhance Antimicrobial Drug Activity Against Mycobacterium. Current Microbiology. PMID 30603964 DOI: 10.1007/s00284-018-1620-z  0.72
2018 Baranowski C, Welsh MA, Sham LT, Eskandarian HA, Lim HC, Kieser KJ, Wagner JC, McKinney J, Fantner GE, Ioerger TR, Walker S, Bernhardt TG, Rubin EJ, Rego EH. Maturing peptidoglycan requires non-canonical crosslinks to maintain shape. Elife. 7. PMID 30324906 DOI: 10.7554/Elife.37516  0.56
2018 Rubin EJ, Fortune SM. Misunderstanding the goals of animal research. Bmj (Clinical Research Ed.). 360: k759. PMID 29467126  0.76
2018 Wu KJ, Zhang J, Baranowski C, Leung V, Rego EH, Morita YS, Rubin EJ, Boutte CC. Characterization of conserved and novel septal factors in Mycobacterium smegmatis. Journal of Bacteriology. PMID 29311277 DOI: 10.1128/Jb.00649-17  0.56
2017 Franchina FA, Mellors TR, Aliyeva M, Wagner J, Daphtary N, Lundblad L, Fortune SM, Rubin EJ, Hill JE. Towards the use of breath for detecting mycobacterial infection: a case study in a Murine model. Journal of Breath Research. PMID 29219122 DOI: 10.1088/1752-7163/aaa016  0.76
2017 Lehmann J, Cheng TY, Aggarwal A, Park AS, Zeiler E, Raju RM, Akopian T, Kandror O, Bach NC, Sacchettini JC, Moody DB, Rubin EJ, Sieber SA. An antibacterial β-lactone kills Mycobacterium tuberculosis by infiltrating mycolic acid biosynthesis. Angewandte Chemie (International Ed. in English). PMID 29067779 DOI: 10.1002/Anie.201709365  0.4
2017 Yadon AN, Maharaj K, Adamson JH, Lai YP, Sacchettini JC, Ioerger TR, Rubin EJ, Pym AS. A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide. Nature Communications. 8: 588. PMID 28928454 DOI: 10.1038/S41467-017-00721-2  0.4
2017 Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, ... ... Rubin EJ, et al. Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Cell. PMID 28669536 DOI: 10.1016/J.Cell.2017.06.025  0.4
2017 Rego EH, Audette RE, Rubin EJ. Deletion of a mycobacterial divisome factor collapses single-cell phenotypic heterogeneity. Nature. 546: 153-157. PMID 28569798 DOI: 10.1038/nature22361  0.56
2017 Rock JM, Hopkins FF, Chavez A, Diallo M, Chase MR, Gerrick ER, Pritchard JR, Church GM, Rubin EJ, Sassetti CM, Schnappinger D, Fortune SM. Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform. Nature Microbiology. 2: 16274. PMID 28165460 DOI: 10.1038/Nmicrobiol.2016.274  0.76
2017 DeJesus MA, Gerrick ER, Xu W, Park SW, Long JE, Boutte CC, Rubin EJ, Schnappinger D, Ehrt S, Fortune SM, Sassetti CM, Ioerger TR. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mbio. 8. PMID 28096490 DOI: 10.1128/Mbio.02133-16  0.76
2016 Baranowski C, Rubin EJ. Could Killing Bacterial Subpopulations Hit Tuberculosis out of the Park? Journal of Medicinal Chemistry. PMID 27322073 DOI: 10.1021/acs.jmedchem.6b00875  0.44
2016 Boutte CC, Baer CE, Papavinasasundaram K, Liu W, Chase MR, Meniche X, Fortune SM, Sassetti CM, Ioerger TR, Rubin EJ. A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis. Elife. 5. PMID 27304077 DOI: 10.7554/Elife.14590  1
2016 Filippova EV, Kieser KJ, Luan CH, Wawrzak Z, Kiryukhina O, Rubin EJ, Anderson WF. Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin binding protein PonA1 reveal potential mechanisms of antibiotic resistance. The Febs Journal. PMID 27101811 DOI: 10.1111/febs.13738  0.36
2016 Marakalala MJ, Raju RM, Sharma K, Zhang YJ, Eugenin EA, Prideaux B, Daudelin IB, Chen PY, Booty MG, Kim JH, Eum SY, Via LE, Behar SM, Barry CE, Mann M, ... ... Rubin EJ, et al. Inflammatory signaling in human tuberculosis granulomas is spatially organized. Nature Medicine. PMID 27043495 DOI: 10.1038/Nm.4073  0.4
2016 Raju RM, Raju SM, Zhao Y, Rubin EJ. Leveraging Advances in Tuberculosis Diagnosis and Treatment to Address Nontuberculous Mycobacterial Disease. Emerging Infectious Diseases. 22: 365-9. PMID 26886068 DOI: 10.3201/eid2203.151643  0.4
2016 Martinot AJ, Farrow M, Bai L, Layre E, Cheng TY, Tsai JH, Iqbal J, Annand JW, Sullivan ZA, Hussain MM, Sacchettini J, Moody DB, Seeliger JC, Rubin EJ. Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis. Plos Pathogens. 12: e1005351. PMID 26751071 DOI: 10.1371/Journal.Ppat.1005351  1
2015 Kieser KJ, Baranowski C, Chao MC, Long JE, Sassetti CM, Waldor MK, Sacchettini JC, Ioerger TR, Rubin EJ. Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility. Proceedings of the National Academy of Sciences of the United States of America. 112: 13087-92. PMID 26438867 DOI: 10.1073/Pnas.1514135112  1
2015 Kieser KJ, Boutte CC, Kester JC, Baer CE, Barczak AK, Meniche X, Chao MC, Rego EH, Sassetti CM, Fortune SM, Rubin EJ. Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria. Plos Pathogens. 11: e1005010. PMID 26114871 DOI: 10.1371/Journal.Ppat.1005010  1
2015 Moreira W, Ngan GJ, Low JL, Poulsen A, Chia BC, Ang MJ, Yap A, Fulwood J, Lakshmanan U, Lim J, Khoo AY, Flotow H, Hill J, Raju RM, Rubin EJ, et al. Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria. Mbio. 6: e00253-15. PMID 25944857 DOI: 10.1128/mBio.00253-15  1
2015 Madigan CA, Martinot AJ, Wei JR, Madduri A, Cheng TY, Young DC, Layre E, Murry JP, Rubin EJ, Moody DB. Lipidomic analysis links mycobactin synthase K to iron uptake and virulence in M. tuberculosis. Plos Pathogens. 11: e1004792. PMID 25815898 DOI: 10.1371/journal.ppat.1004792  0.56
2015 Akopian T, Kandror O, Tsu C, Lai JH, Wu W, Liu Y, Zhao P, Park A, Wolf L, Dick LR, Rubin EJ, Bachovchin W, Goldberg AL. Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity. The Journal of Biological Chemistry. 290: 11008-20. PMID 25759383 DOI: 10.1074/jbc.M114.625640  0.32
2015 Baer CE, Rubin EJ, Sassetti CM. New insights into TB physiology suggest untapped therapeutic opportunities. Immunological Reviews. 264: 327-43. PMID 25703570 DOI: 10.1111/Imr.12267  0.44
2015 Landeta C, Blazyk JL, Hatahet F, Meehan BM, Eser M, Myrick A, Bronstain L, Minami S, Arnold H, Ke N, Rubin EJ, Furie BC, Furie B, Beckwith J, Dutton R, et al. Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria. Nature Chemical Biology. 11: 292-8. PMID 25686372 DOI: 10.1038/nchembio.1752  0.36
2015 Dragset MS, Poce G, Alfonso S, Padilla-Benavides T, Ioerger TR, Kaneko T, Sacchettini JC, Biava M, Parish T, Argüello JM, Steigedal M, Rubin EJ. A novel antimycobacterial compound acts as an intracellular iron chelator. Antimicrobial Agents and Chemotherapy. 59: 2256-64. PMID 25645825 DOI: 10.1128/Aac.05114-14  1
2014 Trauner A, Sassetti CM, Rubin EJ. Genetic Strategies for Identifying New Drug Targets. Microbiology Spectrum. 2: MGM2-0030-2013. PMID 26104208 DOI: 10.1128/microbiolspec.MGM2-0030-2013  1
2014 Pritchard JR, Chao MC, Abel S, Davis BM, Baranowski C, Zhang YJ, Rubin EJ, Waldor MK. ARTIST: high-resolution genome-wide assessment of fitness using transposon-insertion sequencing. Plos Genetics. 10: e1004782. PMID 25375795 DOI: 10.1371/journal.pgen.1004782  1
2014 Santa Maria JP, Sadaka A, Moussa SH, Brown S, Zhang YJ, Rubin EJ, Gilmore MS, Walker S. Compound-gene interaction mapping reveals distinct roles for Staphylococcus aureus teichoic acids. Proceedings of the National Academy of Sciences of the United States of America. 111: 12510-5. PMID 25104751 DOI: 10.1073/Pnas.1404099111  1
2014 Mir M, Prisic S, Kang CM, Lun S, Guo H, Murry JP, Rubin EJ, Husson RN. Mycobacterial gene cuvA is required for optimal nutrient utilization and virulence. Infection and Immunity. 82: 4104-17. PMID 25047842 DOI: 10.1128/Iai.02207-14  1
2014 Kieser KJ, Rubin EJ. How sisters grow apart: mycobacterial growth and division. Nature Reviews. Microbiology. 12: 550-62. PMID 24998739 DOI: 10.1038/nrmicro3299  1
2014 Mavrici D, Marakalala MJ, Holton JM, Prigozhin DM, Gee CL, Zhang YJ, Rubin EJ, Alber T. Mycobacterium tuberculosis FtsX extracellular domain activates the peptidoglycan hydrolase, RipC. Proceedings of the National Academy of Sciences of the United States of America. 111: 8037-42. PMID 24843173 DOI: 10.1073/Pnas.1321812111  1
2014 Ngubane NA, Gresh L, Pym A, Rubin EJ, Khati M. Selection of RNA aptamers against the M. tuberculosis EsxG protein using surface plasmon resonance-based SELEX. Biochemical and Biophysical Research Communications. 449: 114-9. PMID 24813997 DOI: 10.1016/j.bbrc.2014.04.163  1
2014 Siegrist MS, Steigedal M, Ahmad R, Mehra A, Dragset MS, Schuster BM, Philips JA, Carr SA, Rubin EJ. Mycobacterial Esx-3 requires multiple components for iron acquisition. Mbio. 5: e01073-14. PMID 24803520 DOI: 10.1128/mBio.01073-14  1
2014 Raju RM, Jedrychowski MP, Wei JR, Pinkham JT, Park AS, O'Brien K, Rehren G, Schnappinger D, Gygi SP, Rubin EJ. Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis. Plos Pathogens. 10: e1003994. PMID 24603869 DOI: 10.1371/Journal.Ppat.1003994  1
2014 Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT. Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. Plos Pathogens. 10: e1003946. PMID 24586159 DOI: 10.1371/Journal.Ppat.1003946  1
2014 Rodionova IA, Schuster BM, Guinn KM, Sorci L, Scott DA, Li X, Kheterpal I, Shoen C, Cynamon M, Locher C, Rubin EJ, Osterman AL. Metabolic and bactericidal effects of targeted suppression of NadD and NadE enzymes in mycobacteria. Mbio. 5. PMID 24549842 DOI: 10.1128/mBio.00747-13  1
2014 Layre E, Lee HJ, Young DC, Martinot AJ, Buter J, Minnaard AJ, Annand JW, Fortune SM, Snider BB, Matsunaga I, Rubin EJ, Alber T, Moody DB. Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c. Proceedings of the National Academy of Sciences of the United States of America. 111: 2978-83. PMID 24516143 DOI: 10.1073/Pnas.1315883111  1
2014 Javid B, Sorrentino F, Toosky M, Zheng W, Pinkham JT, Jain N, Pan M, Deighan P, Rubin EJ. Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance. Proceedings of the National Academy of Sciences of the United States of America. 111: 1132-7. PMID 24395793 DOI: 10.1073/pnas.1317580111  1
2014 Jean-Francois FL, Dai J, Yu L, Myrick A, Rubin E, Fajer PG, Song L, Zhou HX, Cross TA. Binding of MgtR, a Salmonella transmembrane regulatory peptide, to MgtC, a Mycobacterium tuberculosis virulence factor: a structural study. Journal of Molecular Biology. 426: 436-46. PMID 24140750 DOI: 10.1016/J.Jmb.2013.10.014  1
2013 Zhang YJ, Reddy MC, Ioerger TR, Rothchild AC, Dartois V, Schuster BM, Trauner A, Wallis D, Galaviz S, Huttenhower C, Sacchettini JC, Behar SM, Rubin EJ. Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing. Cell. 155: 1296-308. PMID 24315099 DOI: 10.1016/J.Cell.2013.10.045  1
2013 Ngubane NA, Gresh L, Ioerger TR, Sacchettini JC, Zhang YJ, Rubin EJ, Pym A, Khati M. High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria. Plos One. 8: e77844. PMID 24265677 DOI: 10.1371/Journal.Pone.0077844  1
2013 Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE, Sherman DR, Parish T, Sacchettini JC. Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. Plos One. 8: e75245. PMID 24086479 DOI: 10.1371/Journal.Pone.0075245  1
2013 Farhat MR, Shapiro BJ, Kieser KJ, Sultana R, Jacobson KR, Victor TC, Warren RM, Streicher EM, Calver A, Sloutsky A, Kaur D, Posey JE, Plikaytis B, Oggioni MR, Gardy JL, ... ... Rubin EJ, et al. Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis. Nature Genetics. 45: 1183-9. PMID 23995135 DOI: 10.1038/ng.2747  1
2013 Chao MC, Pritchard JR, Zhang YJ, Rubin EJ, Livny J, Davis BM, Waldor MK. High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data. Nucleic Acids Research. 41: 9033-48. PMID 23901011 DOI: 10.1093/nar/gkt654  1
2013 Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, Aquadro JA, Grant SS, Rubin EJ, Hung DT. Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32. Proceedings of the National Academy of Sciences of the United States of America. 110: 11565-70. PMID 23798446 DOI: 10.1073/Pnas.1302114110  1
2013 Zheng J, Rubin EJ, Bifani P, Mathys V, Lim V, Au M, Jang J, Nam J, Dick T, Walker JR, Pethe K, Camacho LR. para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis. The Journal of Biological Chemistry. 288: 23447-56. PMID 23779105 DOI: 10.1074/jbc.M113.475798  1
2013 Zhang YJ, Rubin EJ. Feast or famine: the host-pathogen battle over amino acids. Cellular Microbiology. 15: 1079-87. PMID 23521858 DOI: 10.1111/cmi.12140  1
2013 Chao MC, Kieser KJ, Minami S, Mavrici D, Aldridge BB, Fortune SM, Alber T, Rubin EJ. Protein complexes and proteolytic activation of the cell wall hydrolase RipA regulate septal resolution in mycobacteria. Plos Pathogens. 9: e1003197. PMID 23468634 DOI: 10.1371/Journal.Ppat.1003197  1
2013 DeJesus MA, Zhang YJ, Sassetti CM, Rubin EJ, Sacchettini JC, Ioerger TR. Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries. Bioinformatics (Oxford, England). 29: 695-703. PMID 23361328 DOI: 10.1093/Bioinformatics/Btt043  1
2012 Zhang YJ, Ioerger TR, Huttenhower C, Long JE, Sassetti CM, Sacchettini JC, Rubin EJ. Global assessment of genomic regions required for growth in Mycobacterium tuberculosis. Plos Pathogens. 8: e1002946. PMID 23028335 DOI: 10.1371/Journal.Ppat.1002946  1
2012 Raju RM, Goldberg AL, Rubin EJ. Bacterial proteolytic complexes as therapeutic targets. Nature Reviews. Drug Discovery. 11: 777-89. PMID 23023677 DOI: 10.1038/nrd3846  1
2012 Robertson BD, Altmann D, Barry C, Bishai B, Cole S, Dick T, Duncan K, Dye C, Ehrt S, Esmail H, Flynn J, Hafner R, Handley G, Hanekom W, van Helden P, ... ... Rubin E, et al. Detection and treatment of subclinical tuberculosis. Tuberculosis (Edinburgh, Scotland). 92: 447-52. PMID 22819716 DOI: 10.1016/J.Tube.2012.06.004  1
2012 Raju RM, Unnikrishnan M, Rubin DH, Krishnamoorthy V, Kandror O, Akopian TN, Goldberg AL, Rubin EJ. Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection. Plos Pathogens. 8: e1002511. PMID 22359499 DOI: 10.1371/journal.ppat.1002511  1
2012 Akopian T, Kandror O, Raju RM, Unnikrishnan M, Rubin EJ, Goldberg AL. The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring. The Embo Journal. 31: 1529-41. PMID 22286948 DOI: 10.1038/emboj.2012.5  1
2012 Gee CL, Papavinasasundaram KG, Blair SR, Baer CE, Falick AM, King DS, Griffin JE, Venghatakrishnan H, Zukauskas A, Wei JR, Dhiman RK, Crick DC, Rubin EJ, Sassetti CM, Alber T. A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria. Science Signaling. 5: ra7. PMID 22275220 DOI: 10.1126/Scisignal.2002525  1
2012 Madigan CA, Cheng TY, Layre E, Young DC, McConnell MJ, Debono CA, Murry JP, Wei JR, Barry CE, Rodriguez GM, Matsunaga I, Rubin EJ, Moody DB. Lipidomic discovery of deoxysiderophores reveals a revised mycobactin biosynthesis pathway in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 109: 1257-62. PMID 22232695 DOI: 10.1073/pnas.1109958109  1
2012 La Rosa V, Poce G, Canseco JO, Buroni S, Pasca MR, Biava M, Raju RM, Porretta GC, Alfonso S, Battilocchio C, Javid B, Sorrentino F, Ioerger TR, Sacchettini JC, Manetti F, ... ... Rubin EJ, et al. MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrobial Agents and Chemotherapy. 56: 324-31. PMID 22024828 DOI: 10.1128/Aac.05270-11  1
2011 Keren I, Minami S, Rubin E, Lewis K. Characterization and transcriptome analysis of Mycobacterium tuberculosis persisters. Mbio. 2: e00100-11. PMID 21673191 DOI: 10.1128/mBio.00100-11  0.36
2011 Horsburgh CR, Rubin EJ. Clinical practice. Latent tuberculosis infection in the United States. The New England Journal of Medicine. 364: 1441-8. PMID 21488766 DOI: 10.1056/NEJMcp1005750  1
2011 Wei JR, Krishnamoorthy V, Murphy K, Kim JH, Schnappinger D, Alber T, Sassetti CM, Rhee KY, Rubin EJ. Depletion of antibiotic targets has widely varying effects on growth. Proceedings of the National Academy of Sciences of the United States of America. 108: 4176-81. PMID 21368134 DOI: 10.1073/Pnas.1018301108  1
2011 Kim JH, Wei JR, Wallach JB, Robbins RS, Rubin EJ, Schnappinger D. Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase. Nucleic Acids Research. 39: 2210-20. PMID 21075796 DOI: 10.1093/nar/gkq1149  1
2010 Fortune SM, Rubin EJ. Host transcription in active and latent tuberculosis. Genome Biology. 11: 135. PMID 20920149 DOI: 10.1186/gb-2010-11-9-135  1
2010 Chao MC, Rubin EJ. Letting sleeping dos lie: does dormancy play a role in tuberculosis? Annual Review of Microbiology. 64: 293-311. PMID 20825351 DOI: 10.1146/annurev.micro.112408.134043  1
2010 Freundlich JS, Lalgondar M, Wei JR, Swanson S, Sorensen EJ, Rubin EJ, Sacchettini JC. The abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland). 90: 298-300. PMID 20739223 DOI: 10.1016/J.Tube.2010.08.002  1
2010 Hett EC, Chao MC, Rubin EJ. Interaction and modulation of two antagonistic cell wall enzymes of mycobacteria. Plos Pathogens. 6: e1001020. PMID 20686708 DOI: 10.1371/journal.ppat.1001020  1
2010 Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC. Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase . Biochemistry. 49: 6746-60. PMID 20565114 DOI: 10.1021/Bi902097J  1
2010 Sassetti CM, Rubin EJ. Relics of selection in the mycobacterial genome. Nature Genetics. 42: 476-8. PMID 20502489 DOI: 10.1038/ng0610-476  1
2010 Dutton RJ, Wayman A, Wei JR, Rubin EJ, Beckwith J, Boyd D. Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin. Proceedings of the National Academy of Sciences of the United States of America. 107: 297-301. PMID 20018758 DOI: 10.1073/pnas.0912952107  1
2009 Siegrist MS, Rubin EJ. Phage transposon mutagenesis. Methods in Molecular Biology (Clifton, N.J.). 465: 311-23. PMID 20560067 DOI: 10.1007/978-1-59745-207-6_21  1
2009 Bitter W, Houben EN, Bottai D, Brodin P, Brown EJ, Cox JS, Derbyshire K, Fortune SM, Gao LY, Liu J, Gey van Pittius NC, Pym AS, Rubin EJ, Sherman DR, Cole ST, et al. Systematic genetic nomenclature for type VII secretion systems. Plos Pathogens. 5: e1000507. PMID 19876390 DOI: 10.1371/Journal.Ppat.1000507  1
2009 Siegrist MS, Unnikrishnan M, McConnell MJ, Borowsky M, Cheng TY, Siddiqi N, Fortune SM, Moody DB, Rubin EJ. Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition. Proceedings of the National Academy of Sciences of the United States of America. 106: 18792-7. PMID 19846780 DOI: 10.1073/pnas.0900589106  1
2009 Murry JP, Pandey AK, Sassetti CM, Rubin EJ. Phthiocerol dimycocerosate transport is required for resisting interferon-gamma-independent immunity. The Journal of Infectious Diseases. 200: 774-82. PMID 19622047 DOI: 10.1086/605128  1
2009 Ranjbar S, Boshoff HI, Mulder A, Siddiqi N, Rubin EJ, Goldfeld AE. HIV-1 replication is differentially regulated by distinct clinical strains of Mycobacterium tuberculosis. Plos One. 4: e6116. PMID 19568431 DOI: 10.1371/journal.pone.0006116  1
2009 Rubin EJ. The granuloma in tuberculosis--friend or foe? The New England Journal of Medicine. 360: 2471-3. PMID 19494225 DOI: 10.1056/NEJMcibr0902539  1
2009 Pandey AK, Raman S, Proff R, Joshi S, Kang CM, Rubin EJ, Husson RN, Sassetti CM. Nitrile-inducible gene expression in mycobacteria. Tuberculosis (Edinburgh, Scotland). 89: 12-6. PMID 18801704 DOI: 10.1016/  1
2008 Wei JR, Rubin EJ. The many roads to essential genes. Tuberculosis (Edinburgh, Scotland). 88: S19-24. PMID 18762149 DOI: 10.1016/S1472-9792(08)70033-7  1
2008 Hett EC, Chao MC, Deng LL, Rubin EJ. A mycobacterial enzyme essential for cell division synergizes with resuscitation-promoting factor. Plos Pathogens. 4: e1000001. PMID 18463693 DOI: 10.1371/journal.ppat.1000001  1
2008 Murry JP, Sassetti CM, Lane JM, Xie Z, Rubin EJ. Transposon site hybridization in Mycobacterium tuberculosis. Methods in Molecular Biology (Clifton, N.J.). 416: 45-59. PMID 18392960 DOI: 10.1007/978-1-59745-321-9_4  1
2008 Hett EC, Rubin EJ. Bacterial growth and cell division: a mycobacterial perspective. Microbiology and Molecular Biology Reviews : Mmbr. 72: 126-56, table of con. PMID 18322037 DOI: 10.1128/MMBR.00028-07  1
2008 Philips JA, Porto MC, Wang H, Rubin EJ, Perrimon N. ESCRT factors restrict mycobacterial growth. Proceedings of the National Academy of Sciences of the United States of America. 105: 3070-5. PMID 18287038 DOI: 10.1073/Pnas.0707206105  1
2008 Zolotarev AS, Unnikrishnan M, Shmukler BE, Clark JS, Vandorpe DH, Grigorieff N, Rubin EJ, Alper SL. Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis. Comparative Biochemistry and Physiology. Part a, Molecular & Integrative Physiology. 149: 255-66. PMID 18255326 DOI: 10.1016/J.Cbpa.2007.12.005  1
2008 Rengarajan J, Murphy E, Park A, Krone CL, Hett EC, Bloom BR, Glimcher LH, Rubin EJ. Mycobacterium tuberculosis Rv2224c modulates innate immune responses. Proceedings of the National Academy of Sciences of the United States of America. 105: 264-9. PMID 18172199 DOI: 10.1073/pnas.0710601105  1
2008 Farrow MF, Rubin EJ. Function of a mycobacterial major facilitator superfamily pump requires a membrane-associated lipoprotein. Journal of Bacteriology. 190: 1783-91. PMID 18156250 DOI: 10.1128/JB.01046-07  1
2008 Sacchettini JC, Rubin EJ, Freundlich JS. Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis. Nature Reviews. Microbiology. 6: 41-52. PMID 18079742 DOI: 10.1038/Nrmicro1816  1
2007 Fortune SM, Rubin EJ. The complex relationship between mycobacteria and macrophages: it's not all bliss. Cell Host & Microbe. 2: 5-6. PMID 18005712 DOI: 10.1016/j.chom.2007.06.008  1
2007 Hett EC, Chao MC, Steyn AJ, Fortune SM, Deng LL, Rubin EJ. A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis. Molecular Microbiology. 66: 658-68. PMID 17919286 DOI: 10.1111/j.1365-2958.2007.05945.x  1
2007 Charity JC, Costante-Hamm MM, Balon EL, Boyd DH, Rubin EJ, Dove SL. Twin RNA polymerase-associated proteins control virulence gene expression in Francisella tularensis. Plos Pathogens. 3: e84. PMID 17571921 DOI: 10.1371/journal.ppat.0030084  1
2007 Sassetti CM, Rubin EJ. The open book of infectious diseases. Nature Medicine. 13: 279-80. PMID 17342136 DOI: 10.1038/nm0307-279  1
2007 Sebastian S, Dillon ST, Lynch JG, Blalock LT, Balon E, Lee KT, Comstock LE, Conlan JW, Rubin EJ, Tzianabos AO, Kasper DL. A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity. Infection and Immunity. 75: 2591-602. PMID 17296751 DOI: 10.1128/IAI.01789-06  1
2006 Joshi SM, Pandey AK, Capite N, Fortune SM, Rubin EJ, Sassetti CM. Characterization of mycobacterial virulence genes through genetic interaction mapping. Proceedings of the National Academy of Sciences of the United States of America. 103: 11760-5. PMID 16868085 DOI: 10.1073/pnas.0603179103  1
2006 Hung DT, Rubin EJ. Chemical biology and bacteria: not simply a matter of life or death. Current Opinion in Chemical Biology. 10: 321-6. PMID 16814591 DOI: 10.1016/j.cbpa.2006.06.016  1
2006 Fortune SM, Chase MR, Rubin EJ. Dividing oceans into pools: strategies for the global analysis of bacterial genes. Microbes and Infection / Institut Pasteur. 8: 1631-6. PMID 16697239 DOI: 10.1016/j.micinf.2005.11.015  1
2006 Diaz R, Siddiqi N, Rubin EJ. Detecting genetic variability among different Mycobacterium tuberculosis strains using DNA microarrays technology. Tuberculosis (Edinburgh, Scotland). 86: 314-8. PMID 16644284 DOI: 10.1016/  1
2006 Lane JM, Rubin EJ. Scaling down: a PCR-based method to efficiently screen for desired knockouts in a high density Mycobacterium tuberculosis picked mutant library. Tuberculosis (Edinburgh, Scotland). 86: 310-3. PMID 16527544 DOI: 10.1016/  1
2005 Nardell EA, Rubin EJ. Once upon a time. . . improved intermittent therapy for tuberculosis--fact or fable? American Journal of Respiratory and Critical Care Medicine. 172: 1361-2. PMID 16301300 DOI: 10.1164/rccm.2509003  1
2005 Murry J, Sassetti CM, Moreira J, Lane J, Rubin EJ. A new site-specific integration system for mycobacteria. Tuberculosis (Edinburgh, Scotland). 85: 317-23. PMID 16256438 DOI: 10.1016/  1
2005 Xie Z, Siddiqi N, Rubin EJ. Differential antibiotic susceptibilities of starved Mycobacterium tuberculosis isolates. Antimicrobial Agents and Chemotherapy. 49: 4778-80. PMID 16251329 DOI: 10.1128/AAC.49.11.4778-4780.2005  1
2005 Fortune SM, Jaeger A, Sarracino DA, Chase MR, Sassetti CM, Sherman DR, Bloom BR, Rubin EJ. Mutually dependent secretion of proteins required for mycobacterial virulence. Proceedings of the National Academy of Sciences of the United States of America. 102: 10676-81. PMID 16030141 DOI: 10.1073/pnas.0504922102  1
2005 Philips JA, Rubin EJ, Perrimon N. Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science (New York, N.Y.). 309: 1251-3. PMID 16020694 DOI: 10.1126/science.1116006  1
2005 Agaisse H, Burrack LS, Philips JA, Rubin EJ, Perrimon N, Higgins DE. Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science (New York, N.Y.). 309: 1248-51. PMID 16020693 DOI: 10.1126/science.1116008  1
2005 Murry JP, Rubin EJ. New genetic approaches shed light on TB virulence. Trends in Microbiology. 13: 366-72. PMID 15982889 DOI: 10.1016/j.tim.2005.06.003  1
2005 Rengarajan J, Bloom BR, Rubin EJ. Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proceedings of the National Academy of Sciences of the United States of America. 102: 8327-32. PMID 15928073 DOI: 10.1073/pnas.0503272102  1
2005 Rubin EJ. Toward a new therapy for tuberculosis. The New England Journal of Medicine. 352: 933-4. PMID 15745987 DOI: 10.1056/NEJMcibr044438  1
2004 Rengarajan J, Sassetti CM, Naroditskaya V, Sloutsky A, Bloom BR, Rubin EJ. The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. Molecular Microbiology. 53: 275-82. PMID 15225321 DOI: 10.1111/j.1365-2958.2004.04120.x  1
2004 Fortune SM, Solache A, Jaeger A, Hill PJ, Belisle JT, Bloom BR, Rubin EJ, Ernst JD. Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms. Journal of Immunology (Baltimore, Md. : 1950). 172: 6272-80. PMID 15128816  1
2003 Sassetti CM, Rubin EJ. Genetic requirements for mycobacterial survival during infection. Proceedings of the National Academy of Sciences of the United States of America. 100: 12989-94. PMID 14569030 DOI: 10.1073/pnas.2134250100  0.44
2003 Sampson SL, Rengarajan J, Rubin EJ. Bacterial genomics and vaccine design. Expert Review of Vaccines. 2: 437-45. PMID 12903808 DOI: 10.1586/14760584.2.3.437  1
2003 Sassetti CM, Boyd DH, Rubin EJ. Genes required for mycobacterial growth defined by high density mutagenesis. Molecular Microbiology. 48: 77-84. PMID 12657046  0.44
2002 Akerley BJ, Rubin EJ, Novick VL, Amaya K, Judson N, Mekalanos JJ. A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae. Proceedings of the National Academy of Sciences of the United States of America. 99: 966-71. PMID 11805338 DOI: 10.1073/Pnas.012602299  1
1999 Lampe DJ, Akerley BJ, Rubin EJ, Mekalanos JJ, Robertson HM. Hyperactive transposase mutants of the Himar1 mariner transposon. Proceedings of the National Academy of Sciences of the United States of America. 96: 11428-33. PMID 10500193 DOI: 10.1073/Pnas.96.20.11428  1
1999 Rubin EJ, Akerley BJ, Novik VN, Lampe DJ, Husson RN, Mekalanos JJ. In vivo transposition of mariner-based elements in enteric bacteria and mycobacteria. Proceedings of the National Academy of Sciences of the United States of America. 96: 1645-50. PMID 9990078 DOI: 10.1073/Pnas.96.4.1645  1
1998 Rubin EJ, Lin W, Mekalanos JJ, Waldor MK. Replication and integration of a Vibrio cholerae cryptic plasmid linked to the CTX prophage Molecular Microbiology. 28: 1247-1254. PMID 9680213 DOI: 10.1046/J.1365-2958.1998.00889.X  1
1998 Akerley BJ, Rubin EJ, Camilli A, Lampe DJ, Robertson HM, Mekalanos JJ. Systematic identification of essential genes by in vitro mariner mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 95: 8927-32. PMID 9671781 DOI: 10.1073/Pnas.95.15.8927  1
1998 Rubin EJ, Mekalanos JJ, Waldor MK. Mobile genetic elements and the evolution of new epidemic strains of Vibrio cholerae Biomedical Research Reports. 1: 147-161. DOI: 10.1016/S1874-5326(07)80028-7  1
1997 Mekalanos JJ, Rubin EJ, Waldor MK. Cholera: Molecular basis for emergence and pathogenesis Fems Immunology and Medical Microbiology. 18: 241-248. PMID 9348159 DOI: 10.1111/J.1574-695X.1997.Tb01052.X  1
1997 Waldor MK, Rubin EJ, Pearson GDN, Kimsey H, Mekalanos JJ. Regulation, replication, and integration functions of the Vibrio cholerae CTXφ are encoded by region RS2 Molecular Microbiology. 24: 917-926. PMID 9220000 DOI: 10.1046/J.1365-2958.1997.3911758.X  1
1988 Popoff MR, Rubin EJ, Gill DM, Boquet P. Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain. Infection and Immunity. 56: 2299-306. PMID 3137166 DOI: 10.1128/iai.56.9.2299-2306.1988  0.32
1988 Rubin EJ, Gill DM, Boquet P, Popoff MR. Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum. Molecular and Cellular Biology. 8: 418-26. PMID 3122025 DOI: 10.1128/MCB.8.1.418  0.32
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