| Year |
Citation |
Score |
| 2023 |
Navratilova E, Qu C, Ji G, Neugebauer V, Guerrero M, Rosen H, Roberts E, Porreca F. Opposing effects on descending control of nociception by mu and kappa opioid receptors in the anterior cingulate cortex. Anesthesiology. PMID 37725756 DOI: 10.1097/ALN.0000000000004773 |
0.414 |
|
| 2023 |
Lee GJ, Porreca F, Navratilova E. Prolactin and pain of endometriosis. Pharmacology & Therapeutics. 247: 108435. PMID 37169264 DOI: 10.1016/j.pharmthera.2023.108435 |
0.32 |
|
| 2023 |
Kopruszinski CM, Porreca F, Chichorro JG. Editorial: Chronic orofacial pain. Frontiers in Pain Research (Lausanne, Switzerland). 3: 1086256. PMID 36688086 DOI: 10.3389/fpain.2022.1086256 |
0.315 |
|
| 2022 |
Kopruszinski CM, Watanabe M, Martinez AL, de Souza LHM, Dodick DW, Moutal A, Neugebauer V, Porreca F, Navratilova E. Kappa opioid receptor agonists produce sexually dimorphic and prolactin-dependent hyperalgesic priming. Pain. PMID 36625833 DOI: 10.1097/j.pain.0000000000002835 |
0.362 |
|
| 2022 |
Yakhnitsa V, Ji G, Hein M, Presto P, Griffin Z, Ponomareva O, Navratilova E, Porreca F, Neugebauer V. Kappa Opioid Receptor Blockade in the Amygdala Mitigates Pain Like-Behaviors by Inhibiting Corticotropin Releasing Factor Neurons in a Rat Model of Functional Pain. Frontiers in Pharmacology. 13: 903978. PMID 35694266 DOI: 10.3389/fphar.2022.903978 |
0.415 |
|
| 2022 |
Sato D, Narita M, Hamada Y, Mori T, Tanaka K, Tamura H, Yamanaka A, Matsui R, Watanabe D, Suda Y, Senba E, Watanabe M, Navratilova E, Porreca F, Kuzumaki N, et al. Relief of neuropathic pain by cell-specific manipulation of nucleus accumbens dopamine D1- and D2-receptor-expressing neurons. Molecular Brain. 15: 10. PMID 34991655 DOI: 10.1186/s13041-021-00896-2 |
0.328 |
|
| 2021 |
Martin L, Ibrahim M, Gomez K, Yu J, Cai S, Chew LA, Bellampalli SS, Moutal A, Largent-Milnes T, Porreca F, Khanna R, Olivera BM, Patwardhan A. Conotoxin contulakin-G engages a neurotensin receptor 2 /R-type calcium channel (Cav2.3) pathway to mediate spinal antinociception. Pain. PMID 35050960 DOI: 10.1097/j.pain.0000000000002561 |
0.793 |
|
| 2021 |
Lançon K, Qu C, Navratilova E, Porreca F, Séguéla P. Decreased dopaminergic inhibition of pyramidal neurons in anterior cingulate cortex maintains chronic neuropathic pain. Cell Reports. 37: 109933. PMID 34852233 DOI: 10.1016/j.celrep.2021.109933 |
0.362 |
|
| 2021 |
Mehr-Un-Nisa, Munawar MA, Rankin D, Hruby VJ, Porreca F, Lee YS. C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters. Bioorganic & Medicinal Chemistry. 51: 116509. PMID 34798381 DOI: 10.1016/j.bmc.2021.116509 |
0.347 |
|
| 2021 |
Bharadwaj VN, Porreca F, Cowan RP, Kori S, Silberstein SD, Yeomans DC. A new hypothesis linking oxytocin to menstrual migraine. Headache. PMID 34125955 DOI: 10.1111/head.14152 |
0.781 |
|
| 2021 |
Phelps CE, Navratilova E, Porreca F. Cognition in the Chronic Pain Experience: Preclinical Insights. Trends in Cognitive Sciences. PMID 33509733 DOI: 10.1016/j.tics.2021.01.001 |
0.301 |
|
| 2021 |
Hein M, Ji G, Tidwell D, D'Souza P, Kiritoshi T, Yakhnitsa V, Navratilova E, Porreca F, Neugebauer V. Kappa opioid receptor activation in the amygdala disinhibits CRF neurons to generate pain-like behaviors. Neuropharmacology. 185: 108456. PMID 33444637 DOI: 10.1016/j.neuropharm.2021.108456 |
0.359 |
|
| 2020 |
Kopruszinski CM, Thornton P, Arnold J, Newton P, Lowne D, Navratilova E, Swiokla J, Dodick DW, Dobson C, Gurrell I, Chessell IP, Porreca F. Characterization and preclinical evaluation of a protease activated receptor 2 (PAR2) monoclonal antibody as a preventive therapy for migraine. Cephalalgia : An International Journal of Headache. 333102420966581. PMID 33131305 DOI: 10.1177/0333102420966581 |
0.301 |
|
| 2020 |
Raghuraman S, Xie JY, Giacobassi MJ, Tun JO, Chase K, Lu D, Teichert RW, Porreca F, Olivera BM. Chronicling changes in the somatosensory neurons after peripheral nerve injury. Proceedings of the National Academy of Sciences of the United States of America. PMID 33020310 DOI: 10.1073/pnas.1922618117 |
0.601 |
|
| 2020 |
Kopruszinski CM, Navratilova E, Swiokla J, Dodick DW, Chessell IP, Porreca F. A novel, injury-free rodent model of vulnerability for assessment of acute and preventive therapies reveals temporal contributions of CGRP-receptor activation in migraine-like pain. Cephalalgia : An International Journal of Headache. 333102420959794. PMID 32985222 DOI: 10.1177/0333102420959794 |
0.323 |
|
| 2020 |
Chen Y, Navratilova E, Dodick DW, Porreca F. An Emerging Role for Prolactin in Female-Selective Pain. Trends in Neurosciences. PMID 32620290 DOI: 10.1016/J.Tins.2020.06.003 |
0.474 |
|
| 2020 |
Navratilova E, Behravesh S, Oyarzo J, Dodick DW, Banerjee P, Porreca F. Ubrogepant does not induce latent sensitization in a preclinical model of medication overuse headache. Cephalalgia : An International Journal of Headache. 333102420938652. PMID 32615788 DOI: 10.1177/0333102420938652 |
0.384 |
|
| 2020 |
Gee TA, Weintraub NC, Lu D, Phelps CE, Navratilova E, Heien ML, Porreca F. A pain-induced tonic hypodopaminergic state augments phasic dopamine release in the nucleus accumbens. Pain. PMID 32453137 DOI: 10.1097/J.Pain.0000000000001925 |
0.358 |
|
| 2020 |
Neugebauer V, Mazzitelli M, Cragg B, Ji G, Navratilova E, Porreca F. Amygdala, neuropeptides, and chronic pain-related affective behaviors. Neuropharmacology. 108052. PMID 32188569 DOI: 10.1016/J.Neuropharm.2020.108052 |
0.435 |
|
| 2020 |
Chen Y, Moutal A, Navratilova E, Kopruszinski C, Yue X, Ikegami M, Chow M, Kanazawa I, Bellampalli SS, Xie J, Patwardhan A, Rice K, Fields H, Akopian A, Neugebauer V, ... ... Porreca F, et al. Erratum: The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females (Science Translational Medicine DOI: 10.1126/scitranslmed.aay7550) Science Translational Medicine. 12. PMID 32132219 DOI: 10.1126/Scitranslmed.Abb4549 |
0.645 |
|
| 2020 |
Kopruszinski CM, Swiokla J, Lee YS, Navratilova E, VanderVeen L, Yang M, Liu Y, Miyazaki T, Schmidt WK, Zalevsky J, Porreca F. Preclinical Assessment of the Analgesic Pharmacology of NKTR-181 in Rodents. Cellular and Molecular Neurobiology. PMID 32107752 DOI: 10.1007/S10571-020-00816-3 |
0.457 |
|
| 2020 |
Chen Y, Moutal A, Navratilova E, Kopruszinski C, Yue X, Ikegami M, Chow M, Kanazawa I, Bellampalli SS, Xie J, Patwardhan A, Rice K, Fields H, Akopian A, Neugebauer V, ... ... Porreca F, et al. The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females. Science Translational Medicine. 12. PMID 32024801 DOI: 10.1126/Scitranslmed.Aay7550 |
0.643 |
|
| 2020 |
Dickenson AH, Navratilova E, Patel R, Porreca F, Bannister K. Supraspinal Opioid Circuits Differentially Modulate Spinal Neuronal Responses in Neuropathic Rats. Anesthesiology. PMID 31977518 DOI: 10.1097/Aln.0000000000003120 |
0.496 |
|
| 2019 |
Christensen SL, Hansen RB, Storm MA, Olesen J, Hansen TF, Ossipov M, Izarzugaza JMG, Porreca F, Kristensen DM. Von Frey testing revisited - provision of an online algorithm for improved accuracy of 50% thresholds. European Journal of Pain (London, England). PMID 31889375 DOI: 10.1002/Ejp.1528 |
0.369 |
|
| 2019 |
Khanna R, Patwardhan A, Yang X, Li W, Cai S, Ji Y, Chew LA, Dorame A, Bellampalli SS, Schmoll RW, Gordon J, Moutal A, Vanderah TW, Porreca F, Ibrahim MM. Erratum to ‛Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light': The Journal of Pain 20 (2019) 1293-1306. The Journal of Pain : Official Journal of the American Pain Society. 20: 1509. PMID 31818395 DOI: 10.1016/J.Jpain.2019.11.012 |
0.63 |
|
| 2019 |
Navratilova E, Nation K, Remeniuk B, Neugebauer V, Bannister K, Dickenson AH, Porreca F. Selective modulation of tonic aversive qualities of neuropathic pain by morphine in the central nucleus of the amygdala requires endogenous opioid signaling in the anterior cingulate cortex. Pain. PMID 31725062 DOI: 10.1097/J.Pain.0000000000001748 |
0.558 |
|
| 2019 |
Xie JY, Qu C, Munro G, Petersen KA, Porreca F. Antihyperalgesic effects of Meteorin in the rat chronic constriction injury model: a replication study. Pain. 160: 1847-1855. PMID 31335652 DOI: 10.1097/j.pain.0000000000001569 |
0.638 |
|
| 2019 |
Kopruszinski CM, Navratilova E, Vagnerova B, Swiokla J, Patwardhan A, Dodick D, Porreca F. Cannabinoids induce latent sensitization in a preclinical model of medication overuse headache. Cephalalgia : An International Journal of Headache. 333102419865252. PMID 31311288 DOI: 10.1177/0333102419865252 |
0.306 |
|
| 2019 |
Jassar H, Nascimento TD, Kaciroti N, DosSantos MF, Danciu T, Koeppe RA, Smith YR, Bigal ME, Porreca F, Casey KL, Zubieta JK, DaSilva AF. Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system. Neuroimage. Clinical. 23: 101905. PMID 31279240 DOI: 10.1016/J.Nicl.2019.101905 |
0.398 |
|
| 2019 |
Khanna R, Patwardhan A, Yang X, Li W, Cai S, Ji Y, Chew LA, Dorame A, Bellampalli SS, Schmoll RW, Gordon J, Moutal A, Vanderah TW, Porreca F, Ibrahim MM. Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light. The Journal of Pain : Official Journal of the American Pain Society. PMID 31054915 DOI: 10.1016/J.Jpain.2019.04.008 |
0.652 |
|
| 2019 |
Navratilova E, Patwardhan A, Porreca F. Opioid analgesics pass the acid test. Lancet (London, England). 393: 1579-1581. PMID 31007186 DOI: 10.1016/S0140-6736(19)30421-0 |
0.381 |
|
| 2019 |
Xie JY, Qu C, Munro G, Petersen KA, Porreca F. Antihyperalgesic effects of Meteorin in the rat chronic constriction injury (CCI) model: a replication study. Pain. PMID 30908357 DOI: 10.1097/j.pain.0000000000001569 |
0.597 |
|
| 2019 |
Phelps CE, Navratilova E, Dickenson AH, Porreca F, Bannister K. Kappa Opioid Signaling in the Right Central Amygdala Causes Hindpaw Specific Loss of Diffuse Noxious Inhibitory Controls (DNIC) in Experimental Neuropathic Pain. Pain. PMID 30870321 DOI: 10.1097/J.Pain.0000000000001553 |
0.536 |
|
| 2019 |
Witkin JM, Cerne R, Davis PG, Freeman KB, do Carmo JM, Rowlett JK, Methuku KR, Okun A, Gleason SD, Li X, Krambis MJ, Poe M, Li G, Schkeryantz JM, Jahan R, ... ... Porreca F, et al. The α2,3-selective potentiator of GABA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats. Pharmacology, Biochemistry, and Behavior. PMID 30825491 DOI: 10.1016/J.Pbb.2019.02.013 |
0.404 |
|
| 2019 |
Navratilova E, Porreca F. Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously. Neuron. 101: 353-355. PMID 30731054 DOI: 10.1016/J.Neuron.2019.01.034 |
0.388 |
|
| 2019 |
Guerrero M, Urbano M, Kim EK, Gamo Albero AM, Riley S, Abgaryan L, Leaf N, Van Orden LJ, Brown SJ, Xie J, Porreca F, Cameron MD, Rosen H, Roberts E. Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140). Journal of Medicinal Chemistry. PMID 30707578 DOI: 10.1021/Acs.Jmedchem.8B01679 |
0.634 |
|
| 2018 |
Navratilova E, Ji G, Phelps C, Qu C, Hein M, Yakhnitsa V, Neugebauer V, Porreca F. Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain. Pain. PMID 30681985 DOI: 10.1097/J.Pain.0000000000001458 |
0.554 |
|
| 2018 |
Nation KM, Dodick DW, Navratilova E, Porreca F. Sustained exposure to acute migraine medications combined with repeated noxious stimulation dysregulates descending pain modulatory circuits: Relevance to medication overuse headache. Cephalalgia : An International Journal of Headache. 333102418804157. PMID 30286616 DOI: 10.1177/0333102418804157 |
0.418 |
|
| 2018 |
Snyder LM, Chiang MC, Loeza-Alcocer E, Omori Y, Hachisuka J, Sheahan TD, Gale JR, Adelman PC, Sypek EI, Fulton SA, Friedman RL, Wright MC, Duque MG, Lee YS, Hu Z, ... ... Porreca F, et al. Kappa Opioid Receptor Distribution and Function in Primary Afferents. Neuron. 99: 1274-1288.e6. PMID 30236284 DOI: 10.1016/J.Neuron.2018.08.044 |
0.461 |
|
| 2018 |
Johnstone TBC, Xie JY, Qu C, Wasiak DJ, Hogenkamp DJ, Porreca F, Gee KW. Positive Allosteric Modulators of Non-Benzodiazepine γ-Aminobutyric acida Receptor Subtypes for the Treatment of Chronic Pain. Pain. PMID 30204648 DOI: 10.1097/J.Pain.0000000000001392 |
0.704 |
|
| 2018 |
Flores AJ, Bartlett MJ, Root BK, Parent KL, Heien ML, Porreca F, Polt R, Sherman SJ, Falk T. The combination of the opioid glycopeptide MMP-2200 and a NMDA receptor antagonist reduced l-DOPA-induced dyskinesia and MMP-2200 by itself reduced dopamine receptor 2-like agonist-induced dyskinesia. Neuropharmacology. 141: 260-271. PMID 30201210 DOI: 10.1016/J.Neuropharm.2018.09.005 |
0.374 |
|
| 2018 |
Schiene K, Schröder W, Linz K, Frosch S, Tzschentke TM, Christoph T, Xie JY, Porreca F. Inhibition of experimental visceral pain in rodents by cebranopadol. Behavioural Pharmacology. PMID 30161034 DOI: 10.1097/FBP.0000000000000420 |
0.696 |
|
| 2018 |
Gomtsian L, Bannister K, Eyde N, Robles D, Dickenson AH, Porreca F, Navratilova E. Morphine effects within the rodent anterior cingulate cortex and rostral ventromedial medulla reveal separable modulation of affective and sensory qualities of acute or chronic pain. Pain. PMID 30086115 DOI: 10.1097/J.Pain.0000000000001355 |
0.561 |
|
| 2018 |
Patel R, Qu C, Xie JY, Porreca F, Dickenson AH. Selective deficiencies in descending inhibitory modulation in neuropathic rats: implications for enhancing noradrenergic tone. Pain. PMID 29863529 DOI: 10.1097/J.Pain.0000000000001300 |
0.621 |
|
| 2018 |
Remesic M, Macedonio G, Mollica A, Porreca F, Hruby V, Lee YS. Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors. Bioorganic & Medicinal Chemistry. PMID 29858157 DOI: 10.1016/J.Bmc.2018.05.045 |
0.499 |
|
| 2018 |
Cowen SL, Phelps CE, Navratilova E, McKinzie DL, Okun A, Husain O, Gleason SD, Witkin JM, Porreca F. Chronic pain impairs cognitive flexibility and engages novel learning strategies in rats. Pain. PMID 29578947 DOI: 10.1097/J.Pain.0000000000001226 |
0.796 |
|
| 2018 |
Nation KM, DeFelice M, Hernandez PI, Dodick DW, Neugebauer V, Navratilova E, Porreca F. Lateralized Kappa Opioid Receptor Signaling from the Amygdala Central Nucleus Promotes Stress-Induced Functional Pain. Pain. PMID 29369967 DOI: 10.1097/J.Pain.0000000000001167 |
0.455 |
|
| 2018 |
Watanabe M, Narita M, Hamada Y, Yamashita A, Tamura H, Ikegami D, Kondo T, Shinzato T, Shimizu T, Fukuchi Y, Muto A, Okano H, Yamanaka A, Tawfik V, Kuzumaki N, ... ... Porreca F, et al. [EXPRESS] Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer. Molecular Pain. 1744806918756406. PMID 29357732 DOI: 10.1177/1744806918756406 |
0.408 |
|
| 2018 |
Watanabe M, Sugiura Y, Sugiyama E, Narita M, Navratilova E, Kondo T, Uchiyama N, Yamanaka A, Kuzumaki N, Porreca F, Narita M. [EXPRESS] Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: analysis using a microdialysis/mass spectrometry integrated system. Molecular Pain. 1744806918754934. PMID 29310499 DOI: 10.1177/1744806918754934 |
0.347 |
|
| 2017 |
Remeniuk B, King T, Suktankhar D, Nippert A, Li N, Li F, Cheng K, Rice KC, Porreca F. Disease modifying actions of IL-6 blockade in a rat model of bone cancer pain. Pain. PMID 29300279 DOI: 10.1097/J.Pain.0000000000001139 |
0.338 |
|
| 2017 |
Bannister K, Qu C, Navratilova E, Oyarzo J, Xie JY, King T, Dickenson AH, Porreca F. Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain. Pain. PMID 28832395 DOI: 10.1097/J.Pain.0000000000001040 |
0.716 |
|
| 2017 |
Vardanyan RS, Cain JP, Haghighi SM, Kumirov VK, McIntosh MI, Sandweiss AJ, Porreca F, Hruby VJ. Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain. Journal of Heterocyclic Chemistry. 54: 1228-1235. PMID 28819330 DOI: 10.1002/Jhet.2696 |
0.837 |
|
| 2017 |
Moutal A, Yang X, Li W, Gilbraith KB, Luo S, Cai S, François-Moutal L, Chew LA, Yeon SK, Bellampalli SS, Qu C, Xie JY, Ibrahim MM, Khanna M, Park KD, ... Porreca F, et al. CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide. Pain. PMID 28809766 DOI: 10.1097/J.Pain.0000000000001002 |
0.627 |
|
| 2017 |
Garami A, Ibrahim M, Gilbraith K, Khanna R, Pakai E, Miko A, Pinter E, Romanovsky AA, Porreca F, Patwardhan AM. Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents. Anesthesiology. PMID 28806222 DOI: 10.1097/Aln.0000000000001812 |
0.54 |
|
| 2017 |
Chichorro JG, Porreca F, Sessle B. Mechanisms of craniofacial pain. Cephalalgia : An International Journal of Headache. 333102417704187. PMID 28440673 DOI: 10.1177/0333102417704187 |
0.461 |
|
| 2017 |
Havelin J, Imbert I, Sukhtankar D, Remeniuk B, Pelletier I, Gentry J, Okun A, Tiutan T, Porreca F, King T. Mediation of movement-induced breakthrough cancer pain by IB4 binding nociceptors in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28438966 DOI: 10.1523/Jneurosci.1212-16.2017 |
0.834 |
|
| 2017 |
Xie JY, De Felice M, Kopruszinski CM, Eyde N, LaVigne J, Remeniuk B, Hernandez P, Yue X, Goshima N, Ossipov M, King T, Streicher JM, Navratilova E, Dodick D, Rosen H, ... ... Porreca F, et al. Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention. Cephalalgia : An International Journal of Headache. 333102417702120. PMID 28376659 DOI: 10.1177/0333102417702120 |
0.647 |
|
| 2017 |
Remesic MV, Hruby VJ, Porreca F, Lee YS. Recent Advances in the Realm of Allosteric Modulators for the Opioid Receptors for Future Therapeutics. Acs Chemical Neuroscience. PMID 28368571 DOI: 10.1021/Acschemneuro.7B00090 |
0.482 |
|
| 2017 |
Porreca F, Navratilova E. Reward, motivation and emotion of pain and its relief. Pain. PMID 28106670 DOI: 10.1097/J.Pain.0000000000000798 |
0.446 |
|
| 2017 |
Ibrahim MM, Patwardhan A, Gilbraith KB, Moutal A, Yang X, Chew LA, Largent-Milnes T, Malan TP, Vanderah TW, Porreca F, Khanna R. Long-lasting antinociceptive effects of green light in acute and chronic pain in rats. Pain. 158: 347-360. PMID 28092651 DOI: 10.1097/J.Pain.0000000000000767 |
0.841 |
|
| 2016 |
Dearborn M, Pelletier I, Gentry J, Havelin J, Imbert I, Sukhtankar D, Remeniuk B, Porreca F, King T. (306) Pain and pain relief: using motivation to explore mechanisms underlying cancer-induced pain in rats. The Journal of Pain : Official Journal of the American Pain Society. 17: S52. PMID 28162544 DOI: 10.1016/J.Jpain.2016.01.213 |
0.46 |
|
| 2016 |
Moutal A, Eyde N, Telemi E, Park KD, Xie JY, Dodick DW, Porreca F, Khanna R. Efficacy of (S)-Lacosamide in preclinical models of cephalic pain. Pain Reports (Baltimore, Md.). 1. PMID 27917413 DOI: 10.1097/PR9.0000000000000565 |
0.565 |
|
| 2016 |
Rice FL, Xie JY, Albrecht PJ, Acker E, Bourgeois J, Navratilova E, Dodick DW, Porreca F. Anatomy and immunochemical characterization of the non-arterial peptidergic diffuse dural innervation of the rat and Rhesus monkey: Implications for functional regulation and treatment in migraine. Cephalalgia : An International Journal of Headache. PMID 27852962 DOI: 10.1177/0333102416677051 |
0.534 |
|
| 2016 |
Ramos-Colon CN, Lee YS, Remesic MV, Hall SM, LaVigne J, Davis P, Sandweiss AJ, McIntosh MI, Hanson J, Largent-Milnes TM, Vanderah TW, Streicher JM, Porreca F, Hruby VJ. Structure Activity Relationships of [des-Arg(7)]- Dynorphin A Analogues at the Kappa Opioid Receptor. Journal of Medicinal Chemistry. PMID 27797517 DOI: 10.1021/Acs.Jmedchem.6B01411 |
0.826 |
|
| 2016 |
Lee YS, Remesic M, Ramos-Colon C, Hall SM, Kuzmin A, Rankin D, Porreca F, Lai J, Hruby VJ. Cyclic non-opioid dynorphin A analogues for the bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. PMID 27756562 DOI: 10.1016/J.Bmcl.2016.10.010 |
0.478 |
|
| 2016 |
Hall SM, LeBaron L, Ramos-Colon CN, Qu C, Xie JY, Porreca F, Lai J, Lee YS, Hruby VJ. Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain. Acs Chemical Neuroscience. PMID 27619237 DOI: 10.1021/Acschemneuro.6B00258 |
0.693 |
|
| 2016 |
Okun A, McKinzie DL, Witkin JM, Remeniuk B, Husein O, Gleason SD, Oyarzo J, Navratilova E, McElroy B, Cowen S, Kennedy JD, Porreca F. Hedonic and motivational responses to food reward are unchanged in rats with neuropathic pain. Pain. PMID 27548047 DOI: 10.1097/J.Pain.0000000000000695 |
0.823 |
|
| 2016 |
Xie JY, Chew LA, Yang X, Wang Y, Qu C, Wang Y, Federici LM, Fitz SD, Ripsch MS, Due MR, Moutal A, Khanna M, White FA, Vanderah TW, Johnson PL, ... Porreca F, et al. Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential. Pain. 157: 2124-2140. PMID 27537210 DOI: 10.1097/J.Pain.0000000000000628 |
0.746 |
|
| 2016 |
Kopruszinski CM, Xie JY, Eyde NM, Remeniuk B, Walter S, Stratton J, Bigal M, Chichorro JG, Dodick D, Porreca F. Prevention of stress- or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody in rodents. Cephalalgia : An International Journal of Headache. PMID 27206958 DOI: 10.1177/0333102416650702 |
0.539 |
|
| 2016 |
Lee YS, Kupp R, Remesic M, Ramos-Colon C, Hall SM, Chan C, Rankin D, Lai J, Porreca F, Hruby VJ. Various modifications of the amphipathic dynorphin A phamacophore for rat brain bradykinin receptors. Chemical Biology & Drug Design. PMID 27203574 DOI: 10.1111/Cbdd.12789 |
0.459 |
|
| 2016 |
Hitomi S, Kross K, Kurose M, Porreca F, Meng ID. Activation of dura-sensitive trigeminal neurons and increased c-Fos protein induced by morphine withdrawal in the rostral ventromedial medulla. Cephalalgia : An International Journal of Headache. PMID 27155000 DOI: 10.1177/0333102416648655 |
0.376 |
|
| 2016 |
Moutal A, Chew LA, Yang X, Wang Y, Yeon SK, Telemi E, Meroueh S, Park KD, Shrinivasan R, Gilbraith KB, Qu C, Xie JY, Patwardhan A, Vanderah TW, Khanna M, ... Porreca F, et al. (S)-Lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology. Pain. PMID 26967696 DOI: 10.1097/J.Pain.0000000000000555 |
0.716 |
|
| 2016 |
Navratilova E, Morimura K, Xie JY, Atcherley CW, Ossipov MH, Porreca F. Positive emotions and brain reward circuits in chronic pain. The Journal of Comparative Neurology. PMID 26788716 DOI: 10.1002/Cne.23968 |
0.634 |
|
| 2016 |
Raffa RB, Ossipov MH, Porreca F. 16 – Opioid Analgesics and Antagonists Pharmacology and Therapeutics in Dentistry. 241-256. DOI: 10.1016/B978-0-323-39307-2.00016-3 |
0.442 |
|
| 2016 |
Vardanyan RS, Cain JP, Haghighi SM, Kumirov VK, Mcintosh MI, Sandweiss AJ, Porreca F, Hruby VJ. Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain Journal of Heterocyclic Chemistry. DOI: 10.1002/jhet.2696 |
0.828 |
|
| 2015 |
Havelin J, Imbert I, Cormier J, Allen J, Porreca F, King T. Central sensitization and neuropathic features of ongoing pain in a rat model of advanced osteoarthritis. The Journal of Pain : Official Journal of the American Pain Society. PMID 26694132 DOI: 10.1016/j.jpain.2015.12.001 |
0.472 |
|
| 2015 |
Andrews NA, Latrémolière A, Basbaum AI, Mogil JS, Porreca F, Rice AS, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, et al. Ensuring transparency and minimization of methodologic bias in preclinical pain research: Pprecise considerations. Pain. PMID 26683237 DOI: 10.1097/J.Pain.0000000000000458 |
0.568 |
|
| 2015 |
Navratilova E, Atcherley CW, Porreca F. Brain Circuits Encoding Reward from Pain Relief. Trends in Neurosciences. PMID 26603560 DOI: 10.1016/J.Tins.2015.09.003 |
0.416 |
|
| 2015 |
Becerra L, Bishop J, Barmettler G, Xie JY, Navratilova E, Porreca F, Borsook D. Triptans Disrupt Brain Networks and Promote Stress-induced CSD-like Responses in Cortical and Subcortical Areas. Journal of Neurophysiology. jn.00632.2015. PMID 26490291 DOI: 10.1152/Jn.00632.2015 |
0.544 |
|
| 2015 |
Giri AK, Apostol CR, Wang Y, Forte BL, Largent-Milnes TM, Davis P, Rankin D, Molnar G, Olson KM, Porreca F, Vanderah TW, Hruby VJ. Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain. Journal of Medicinal Chemistry. PMID 26465170 DOI: 10.1021/Acs.Jmedchem.5B01170 |
0.818 |
|
| 2015 |
Harasawa I, Johansen JP, Fields HL, Porreca F, Meng ID. Alterations in the rostral ventromedial medulla after the selective ablation of mu-opioid receptor expressing neurons. Pain. PMID 26335909 DOI: 10.1097/J.Pain.0000000000000344 |
0.43 |
|
| 2015 |
Deekonda S, Wugalter L, Rankin D, Largent-Milnes TM, Davis P, Wang Y, Bassirirad NM, Lai J, Kulkarni V, Vanderah TW, Porreca F, Hruby VJ. Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 26323872 DOI: 10.1016/J.Bmcl.2015.07.064 |
0.826 |
|
| 2015 |
Deekonda S, Rankin D, Davis P, Lai J, Porreca F, Hruby VJ. Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors. Bioorganic & Medicinal Chemistry Letters. 25: 4148-52. PMID 26316468 DOI: 10.1016/J.Bmcl.2015.08.014 |
0.434 |
|
| 2015 |
Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands. Bioorganic & Medicinal Chemistry. 23: 6185-94. PMID 26299827 DOI: 10.1016/J.Bmc.2015.07.071 |
0.829 |
|
| 2015 |
Lee YS, Hall SM, Ramos-Colon C, Remesic M, Rankin D, Vanderah TW, Porreca F, Lai J, Hruby VJ. Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors. Receptors & Clinical Investigation. 2. PMID 26221618 DOI: 10.14800/Rci.517 |
0.735 |
|
| 2015 |
Nair P, Yamamoto T, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 25: 3716-20. PMID 26212775 DOI: 10.1016/J.Bmcl.2015.06.030 |
0.635 |
|
| 2015 |
Remeniuk B, Sukhtankar D, Okun A, Navratilova E, Xie JY, King T, Porreca F. Behavioral and Neurochemical Analysis of Ongoing Bone Cancer Pain in Rats. Pain. PMID 25955964 DOI: 10.1097/J.Pain.0000000000000218 |
0.832 |
|
| 2015 |
Navratilova E, Xie JY, Meske D, Qu C, Morimura K, Okun A, Arakawa N, Ossipov M, Fields HL, Porreca F. Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 7264-71. PMID 25948274 DOI: 10.1523/Jneurosci.3862-14.2015 |
0.857 |
|
| 2015 |
Vreeland RF, Atcherley CW, Russell WS, Xie JY, Lu D, Laude ND, Porreca F, Heien ML. Biocompatible PEDOT:Nafion composite electrode coatings for selective detection of neurotransmitters in vivo. Analytical Chemistry. 87: 2600-7. PMID 25692657 DOI: 10.1021/Ac502165F |
0.51 |
|
| 2015 |
Guillemyn K, Kleczkowska P, Lesniak A, Dyniewicz J, Van der Poorten O, Van den Eynde I, Keresztes A, Varga E, Lai J, Porreca F, Chung NN, Lemieux C, Mika J, Rojewska E, Makuch W, et al. Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics. European Journal of Medicinal Chemistry. 92: 64-77. PMID 25544687 DOI: 10.1016/j.ejmech.2014.12.033 |
0.562 |
|
| 2015 |
Lee YS, Hall SM, Ramos-Colon C, Remesic M, LeBaron L, Nguyen A, Rankin D, Porreca F, Lai J, Hruby VJ. Modification of amphipathic non-opioid dynorphin A analogues for rat brain bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. 25: 30-3. PMID 25434001 DOI: 10.1016/J.Bmcl.2014.11.026 |
0.487 |
|
| 2015 |
Little JW, Ford A, Symons-Liguori AM, Chen Z, Janes K, Doyle T, Xie J, Luongo L, Tosh DK, Maione S, Bannister K, Dickenson AH, Vanderah TW, Porreca F, Jacobson KA, et al. Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain : a Journal of Neurology. 138: 28-35. PMID 25414036 DOI: 10.1093/Brain/Awu330 |
0.785 |
|
| 2015 |
Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands Bioorganic and Medicinal Chemistry. 23: 6185-6194. DOI: 10.1016/j.bmc.2015.07.071 |
0.795 |
|
| 2014 |
Lee YS, Rankin D, Hall SM, Ramos-Colon C, Ortiz JJ, Kupp R, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of non-opioid [des-Arg(7)]-dynorphin A analogues for bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. 24: 4976-9. PMID 25282551 DOI: 10.1016/J.Bmcl.2014.09.033 |
0.414 |
|
| 2014 |
Navratilova E, Porreca F. Reward and motivation in pain and pain relief. Nature Neuroscience. 17: 1304-12. PMID 25254980 DOI: 10.1038/Nn.3811 |
0.439 |
|
| 2014 |
Mollica A, Carotenuto A, Novellino E, Limatola A, Costante R, Pinnen F, Stefanucci A, Pieretti S, Borsodi A, Samavati R, Zador F, Benyhe S, Davis P, Porreca F, Hruby VJ. Novel cyclic biphalin analogue with improved antinociceptive properties. Acs Medicinal Chemistry Letters. 5: 1032-6. PMID 25221662 DOI: 10.1021/Ml500241N |
0.352 |
|
| 2014 |
Dussor G, Yan J, Xie JY, Ossipov MH, Dodick DW, Porreca F. Targeting TRP channels for novel migraine therapeutics. Acs Chemical Neuroscience. 5: 1085-96. PMID 25138211 DOI: 10.1021/Cn500083E |
0.747 |
|
| 2014 |
Borsook D, Hargreaves R, Bountra C, Porreca F. Lost but making progress--Where will new analgesic drugs come from? Science Translational Medicine. 6: 249sr3. PMID 25122640 DOI: 10.1126/Scitranslmed.3008320 |
0.426 |
|
| 2014 |
King T, Porreca F. Preclinical assessment of pain: improving models in discovery research. Current Topics in Behavioral Neurosciences. 20: 101-20. PMID 25012511 DOI: 10.1007/7854_2014_330 |
0.434 |
|
| 2014 |
Bannister K, Lee YS, Goncalves L, Porreca F, Lai J, Dickenson AH. Neuropathic plasticity in the opioid and non-opioid actions of dynorphin A fragments and their interactions with bradykinin B2 receptors on neuronal activity in the rat spinal cord. Neuropharmacology. 85: 375-83. PMID 24937046 DOI: 10.1016/J.Neuropharm.2014.06.005 |
0.578 |
|
| 2014 |
Xie JY, Qu C, Patwardhan A, Ossipov MH, Navratilova E, Becerra L, Borsook D, Porreca F. Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: a potential biomarker of efficacy. Pain. 155: 1659-66. PMID 24861580 DOI: 10.1016/J.Pain.2014.05.018 |
0.671 |
|
| 2014 |
Ossipov MH, Morimura K, Porreca F. Descending pain modulation and chronification of pain. Current Opinion in Supportive and Palliative Care. 8: 143-51. PMID 24752199 DOI: 10.1097/SPC.0000000000000055 |
0.445 |
|
| 2014 |
Lee YS, Muthu D, Hall SM, Ramos-Colon C, Rankin D, Hu J, Sandweiss AJ, De Felice M, Xie JY, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord. Journal of the American Chemical Society. 136: 6608-16. PMID 24742335 DOI: 10.1021/Ja501677Q |
0.836 |
|
| 2014 |
Fillingim RB, Bruehl S, Dworkin RH, Dworkin SF, Loeser JD, Turk DC, Widerstrom-Noga E, Arnold L, Bennett R, Edwards RR, Freeman R, Gewandter J, Hertz S, Hochberg M, Krane E, ... ... Porreca F, et al. The ACTTION-American Pain Society Pain Taxonomy (AAPT): an evidence-based and multidimensional approach to classifying chronic pain conditions. The Journal of Pain : Official Journal of the American Pain Society. 15: 241-9. PMID 24581634 DOI: 10.1016/J.Jpain.2014.01.004 |
0.44 |
|
| 2014 |
Wang R, Rossomando A, Sah DW, Ossipov MH, King T, Porreca F. Artemin induced functional recovery and reinnervation after partial nerve injury. Pain. 155: 476-84. PMID 24269493 DOI: 10.1016/J.Pain.2013.11.007 |
0.563 |
|
| 2014 |
Mamet J, Klukinov M, Yaksh TL, Malkmus SA, Williams S, Harris S, Manning DC, Taylor BK, Donahue RR, Porreca F, Xie JY, Oyarzo J, Brennan TJ, Subieta A, Schmidt WK, et al. Single intrathecal administration of the transcription factor decoy AYX1 prevents acute and chronic pain after incisional, inflammatory, or neuropathic injury. Pain. 155: 322-33. PMID 24145208 DOI: 10.1016/J.Pain.2013.10.015 |
0.661 |
|
| 2014 |
Yoshimura RF, Tran MB, Hogenkamp DJ, Johnstone TB, Xie JY, Porreca F, Gee KW. Limited central side effects of a β-subunit subtype-selective GABAA receptor allosteric modulator. Journal of Psychopharmacology (Oxford, England). 28: 472-8. PMID 24108410 DOI: 10.1177/0269881113507643 |
0.594 |
|
| 2014 |
Meske DS, Xie JY, Oyarzo J, Badghisi H, Ossipov MH, Porreca F. Opioid and noradrenergic contributions of tapentadol in experimental neuropathic pain. Neuroscience Letters. 562: 91-6. PMID 23969300 DOI: 10.1016/J.Neulet.2013.08.017 |
0.674 |
|
| 2013 |
Lee YS, Qu HC, Davis P, Ma SW, Vardanyan R, Lai J, Porreca F, Hruby VJ. Chiral Effect of a Phe Residue in Position 3 of the Dmt(1)-L(or D)-Tic(2) Analogues on Opioid Functional Activities. Acs Medicinal Chemistry Letters. 4: 656-659. PMID 24648867 DOI: 10.1021/Ml400115N |
0.427 |
|
| 2013 |
Nair P, Yamamoto T, Largent-Milnes TM, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 23: 4975-8. PMID 23899615 DOI: 10.1016/J.Bmcl.2013.06.065 |
0.823 |
|
| 2013 |
Largent-Milnes TM, Brookshire SW, Skinner DP, Hanlon KE, Giuvelis D, Yamamoto T, Davis P, Campos CR, Nair P, Deekonda S, Bilsky EJ, Porreca F, Hruby VJ, Vanderah TW. Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects. The Journal of Pharmacology and Experimental Therapeutics. 347: 7-19. PMID 23860305 DOI: 10.1124/Jpet.113.205245 |
0.854 |
|
| 2013 |
Becerra L, Navratilova E, Porreca F, Borsook D. Analogous responses in the nucleus accumbens and cingulate cortex to pain onset (aversion) and offset (relief) in rats and humans. Journal of Neurophysiology. 110: 1221-6. PMID 23785130 DOI: 10.1152/Jn.00284.2013 |
0.448 |
|
| 2013 |
De Felice M, Eyde N, Dodick D, Dussor GO, Ossipov MH, Fields HL, Porreca F. Capturing the aversive state of cephalic pain preclinically. Annals of Neurology. 74: 257-65. PMID 23686557 DOI: 10.1002/ana.23922 |
0.659 |
|
| 2013 |
Stahl SM, Porreca F, Taylor CP, Cheung R, Thorpe AJ, Clair A. The diverse therapeutic actions of pregabalin: is a single mechanism responsible for several pharmacological activities? Trends in Pharmacological Sciences. 34: 332-9. PMID 23642658 DOI: 10.1016/J.Tips.2013.04.001 |
0.35 |
|
| 2013 |
Petrov RR, Lee YS, Vardanyan RS, Liu L, Ma SW, Davis P, Lai J, Porreca F, Vanderah TW, Hruby VJ. Effect of anchoring 4-anilidopiperidines to opioid peptides. Bioorganic & Medicinal Chemistry Letters. 23: 3434-7. PMID 23623418 DOI: 10.1016/J.Bmcl.2013.03.065 |
0.617 |
|
| 2013 |
Wang R, King T, De Felice M, Guo W, Ossipov MH, Porreca F. Descending facilitation maintains long-term spontaneous neuropathic pain. The Journal of Pain : Official Journal of the American Pain Society. 14: 845-53. PMID 23602267 DOI: 10.1016/J.Jpain.2013.02.011 |
0.679 |
|
| 2013 |
Mollica A, Pinnen F, Costante R, Locatelli M, Stefanucci A, Pieretti S, Davis P, Lai J, Rankin D, Porreca F, Hruby VJ. Biological active analogues of the opioid peptide biphalin: mixed α/β(3)-peptides. Journal of Medicinal Chemistry. 56: 3419-23. PMID 23547584 DOI: 10.1021/Jm301456C |
0.384 |
|
| 2013 |
Sui P, Watanabe H, Ossipov MH, Porreca F, Bakalkin G, Bergquist J, Artemenko K. Dimethyl-labeling-based protein quantification and pathway search: a novel method of spinal cord analysis applicable for neurological studies. Journal of Proteome Research. 12: 2245-52. PMID 23520997 DOI: 10.1021/pr4001064 |
0.36 |
|
| 2013 |
Navratilova E, Xie JY, King T, Porreca F. Evaluation of reward from pain relief. Annals of the New York Academy of Sciences. 1282: 1-11. PMID 23496247 DOI: 10.1111/Nyas.12095 |
0.657 |
|
| 2013 |
Taylor R, Pergolizzi JV, Porreca F, Raffa RB. Opioid antagonists for pain. Expert Opinion On Investigational Drugs. 22: 517-25. PMID 23484859 DOI: 10.1517/13543784.2013.778973 |
0.492 |
|
| 2013 |
Lozano-Ondoua AN, Hanlon KE, Symons-Liguori AM, Largent-Milnes TM, Havelin JJ, Ferland HL, Chandramouli A, Owusu-Ankomah M, Nikolich-Zugich T, Bloom AP, Jimenez-Andrade JM, King T, Porreca F, Nelson MA, Mantyh PW, et al. Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 92-107. PMID 22903605 DOI: 10.1002/Jbmr.1732 |
0.812 |
|
| 2012 |
Navratilova E, Xie JY, Okun A, Qu C, Eyde N, Ci S, Ossipov MH, King T, Fields HL, Porreca F. Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry. Proceedings of the National Academy of Sciences of the United States of America. 109: 20709-13. PMID 23184995 DOI: 10.1073/Pnas.1214605109 |
0.82 |
|
| 2012 |
Little JW, Chen Z, Doyle T, Porreca F, Ghaffari M, Bryant L, Neumann WL, Salvemini D. Supraspinal peroxynitrite modulates pain signaling by suppressing the endogenous opioid pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 10797-808. PMID 22875915 DOI: 10.1523/Jneurosci.6345-11.2012 |
0.576 |
|
| 2012 |
Annedi SC, Maddaford SP, Ramnauth J, Renton P, Rybak T, Silverman S, Rakhit S, Mladenova G, Dove P, Andrews JS, Zhang D, Porreca F. Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine. European Journal of Medicinal Chemistry. 55: 94-107. PMID 22840695 DOI: 10.1016/j.ejmech.2012.07.006 |
0.406 |
|
| 2012 |
Edelmayer RM, Le LN, Yan J, Wei X, Nassini R, Materazzi S, Preti D, Appendino G, Geppetti P, Dodick DW, Vanderah TW, Porreca F, Dussor G. Activation of TRPA1 on dural afferents: a potential mechanism of headache pain. Pain. 153: 1949-58. PMID 22809691 DOI: 10.1016/J.Pain.2012.06.012 |
0.818 |
|
| 2012 |
De Felice M, Melchiorri P, Ossipov MH, Vanderah TW, Porreca F, Negri L. Mechanisms of Bv8-induced biphasic hyperalgesia: increased excitatory transmitter release and expression. Neuroscience Letters. 521: 40-5. PMID 22641053 DOI: 10.1016/j.neulet.2012.05.055 |
0.631 |
|
| 2012 |
He Y, Tian X, Hu X, Porreca F, Wang ZJ. Negative reinforcement reveals non-evoked ongoing pain in mice with tissue or nerve injury. The Journal of Pain : Official Journal of the American Pain Society. 13: 598-607. PMID 22609247 DOI: 10.1016/J.Jpain.2012.03.011 |
0.467 |
|
| 2012 |
Pajouhesh H, Feng ZP, Zhang L, Pajouhesh H, Jiang X, Hendricson A, Dong H, Tringham E, Ding Y, Vanderah TW, Porreca F, Belardetti F, Zamponi GW, Mitscher LA, Snutch TP. Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 4153-8. PMID 22579422 DOI: 10.1016/J.Bmcl.2012.04.054 |
0.694 |
|
| 2012 |
Hughes JP, Chessell I, Malamut R, Perkins M, BaÄkonja M, Baron R, Farrar JT, Field MJ, Gereau RW, Gilron I, McMahon SB, Porreca F, Rappaport BA, Rice F, Richman LK, et al. Understanding chronic inflammatory and neuropathic pain. Annals of the New York Academy of Sciences. 1255: 30-44. PMID 22564068 DOI: 10.1111/J.1749-6632.2012.06561.X |
0.432 |
|
| 2012 |
King T, Qu C, Okun A, Melemedjian OK, Mandell EK, Maskaykina IY, Navratilova E, Dussor GO, Ghosh S, Price TJ, Porreca F. Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic pain. Pain. 153: 1263-73. PMID 22482911 DOI: 10.1016/J.Pain.2012.03.006 |
0.844 |
|
| 2012 |
Mladenova G, Annedi SC, Ramnauth J, Maddaford SP, Rakhit S, Andrews JS, Zhang D, Porreca F. First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain. Journal of Medicinal Chemistry. 55: 3488-501. PMID 22420844 DOI: 10.1021/jm300138g |
0.4 |
|
| 2012 |
Mollica A, Pinnen F, Stefanucci A, Feliciani F, Campestre C, Mannina L, Sobolev AP, Lucente G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues. Journal of Medicinal Chemistry. 55: 3027-35. PMID 22394120 DOI: 10.1021/Jm201402V |
0.372 |
|
| 2012 |
Okun A, Liu P, Davis P, Ren J, Remeniuk B, Brion T, Ossipov MH, Xie J, Dussor GO, King T, Porreca F. Afferent drive elicits ongoing pain in a model of advanced osteoarthritis. Pain. 153: 924-33. PMID 22387095 DOI: 10.1016/J.Pain.2012.01.022 |
0.835 |
|
| 2012 |
Annedi SC, Ramnauth J, Cossette M, Maddaford SP, Dove P, Rakhit S, Andrews JS, Porreca F. Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS). Bioorganic & Medicinal Chemistry Letters. 22: 2510-3. PMID 22370270 DOI: 10.1016/j.bmcl.2012.02.004 |
0.34 |
|
| 2012 |
Edelmayer RM, Ossipov MH, Porreca F. An experimental model of headache-related pain. Methods in Molecular Biology (Clifton, N.J.). 851: 109-20. PMID 22351085 DOI: 10.1007/978-1-61779-561-9_7 |
0.77 |
|
| 2012 |
Ramnauth J, Renton P, Dove P, Annedi SC, Speed J, Silverman S, Mladenova G, Maddaford SP, Zinghini S, Rakhit S, Andrews J, Lee DK, Zhang D, Porreca F. 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate. Journal of Medicinal Chemistry. 55: 2882-93. PMID 22335555 DOI: 10.1021/jm3000449 |
0.341 |
|
| 2012 |
Annedi SC, Maddaford SP, Ramnauth J, Renton P, Speed J, Rakhit S, Andrews JS, Porreca F. 3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 1980-4. PMID 22318159 DOI: 10.1016/j.bmcl.2012.01.031 |
0.334 |
|
| 2012 |
Annedi SC, Ramnauth J, Maddaford SP, Renton P, Rakhit S, Mladenova G, Dove P, Silverman S, Andrews JS, Felice MD, Porreca F. Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities. Journal of Medicinal Chemistry. 55: 943-55. PMID 22175766 DOI: 10.1021/jm201564u |
0.36 |
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| 2012 |
Lattanzi R, Sacerdote P, Franchi S, Canestrelli M, Miele R, Barra D, Visentin S, DeNuccio C, Porreca F, De Felice M, Guida F, Luongo L, de Novellis V, Maione S, Negri L. Pharmacological activity of a Bv8 analogue modified in position 24. British Journal of Pharmacology. 166: 950-63. PMID 22122547 DOI: 10.1111/j.1476-5381.2011.01797.x |
0.516 |
|
| 2012 |
Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, et al. The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain : a Journal of Neurology. 135: 376-90. PMID 22036959 DOI: 10.1093/brain/awr272 |
0.669 |
|
| 2012 |
Marshall TM, Herman DS, Largent-Milnes TM, Badghisi H, Zuber K, Holt SC, Lai J, Porreca F, Vanderah TW. Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-Eâ‚‚ in the spinal cord. Pain. 153: 86-94. PMID 22030324 DOI: 10.1016/J.Pain.2011.09.021 |
0.821 |
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| 2012 |
King T, Porreca F. Foreword: Analgesics for cancer pain Analgesics For Cancer Pain. 3-4. DOI: 10.2217/EBO.11.387 |
0.311 |
|
| 2012 |
Mamet J, Klukinov M, Yaksh T, Malkmus S, Williams S, Taylor B, Donahue R, Porreca F, Xie J, Oyarzo J, Brennan T, Subieta A, Harris S, Schmidt W, Yeomans D. AYX1 DNA-decoy compound prevents the maintenance of pain after incisional, inflammatory or neuropathic injury The Journal of Pain. 13: S71. DOI: 10.1016/J.Jpain.2012.01.297 |
0.383 |
|
| 2011 |
Sukhtankar D, Okun A, Chandramouli A, Nelson MA, Vanderah TW, Cress AE, Porreca F, King T. Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain. Molecular Pain. 7: 81. PMID 22014040 DOI: 10.1186/1744-8069-7-81 |
0.811 |
|
| 2011 |
Vardanyan R, Kumirov VK, Nichol GS, Davis P, Liktor-Busa E, Rankin D, Varga E, Vanderah T, Porreca F, Lai J, Hruby VJ. Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands. Bioorganic & Medicinal Chemistry. 19: 6135-42. PMID 21925887 DOI: 10.1016/J.Bmc.2011.08.027 |
0.599 |
|
| 2011 |
Annedi SC, Maddaford SP, Mladenova G, Ramnauth J, Rakhit S, Andrews JS, Lee DK, Zhang D, Porreca F, Bunton D, Christie L. Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain. Journal of Medicinal Chemistry. 54: 7408-16. PMID 21923116 DOI: 10.1021/jm201063u |
0.369 |
|
| 2011 |
Yue X, Falk T, Zuniga LA, Szabò L, Porreca F, Polt R, Sherman SJ. Effects of the novel glycopeptide opioid agonist MMP-2200 in preclinical models of Parkinson's disease. Brain Research. 1413: 72-83. PMID 21840512 DOI: 10.1016/J.Brainres.2011.07.038 |
0.419 |
|
| 2011 |
De Felice M, Sanoja R, Wang R, Vera-Portocarrero L, Oyarzo J, King T, Ossipov MH, Vanderah TW, Lai J, Dussor GO, Fields HL, Price TJ, Porreca F. Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain. Pain. 152: 2701-9. PMID 21745713 DOI: 10.1016/J.Pain.2011.06.008 |
0.846 |
|
| 2011 |
Fioravanti B, Kasasbeh A, Edelmayer R, Skinner DP, Hartings JA, Burklund RD, De Felice M, French ED, Dussor GO, Dodick DW, Porreca F, Vanderah TW. Evaluation of cutaneous allodynia following induction of cortical spreading depression in freely moving rats. Cephalalgia : An International Journal of Headache. 31: 1090-100. PMID 21700643 DOI: 10.1177/0333102411410609 |
0.788 |
|
| 2011 |
Ramnauth J, Speed J, Maddaford SP, Dove P, Annedi SC, Renton P, Rakhit S, Andrews J, Silverman S, Mladenova G, Zinghini S, Nair S, Catalano C, Lee DK, De Felice M, ... Porreca F, et al. Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors. Journal of Medicinal Chemistry. 54: 5562-75. PMID 21699209 DOI: 10.1021/jm200648s |
0.373 |
|
| 2011 |
King T, Qu C, Okun A, Mercado R, Ren J, Brion T, Lai J, Porreca F. Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity. Pain. 152: 1997-2005. PMID 21620567 DOI: 10.1016/J.Pain.2011.04.020 |
0.838 |
|
| 2011 |
Bannister K, Sikandar S, Bauer CS, Dolphin AC, Porreca F, Dickenson AH. Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology. Anesthesiology. 115: 144-52. PMID 21602662 DOI: 10.1097/Aln.0B013E31821F6545 |
0.497 |
|
| 2011 |
Hanlon KE, Herman DS, Agnes RS, Largent-Milnes TM, Kumarasinghe IR, Ma SW, Guo W, Lee YS, Ossipov MH, Hruby VJ, Lai J, Porreca F, Vanderah TW. Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain. Brain Research. 1395: 1-11. PMID 21550594 DOI: 10.1016/J.Brainres.2011.04.024 |
0.858 |
|
| 2011 |
Asiedu MN, Tillu DV, Melemedjian OK, Shy A, Sanoja R, Bodell B, Ghosh S, Porreca F, Price TJ. Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6646-53. PMID 21543593 DOI: 10.1523/Jneurosci.6286-10.2011 |
0.788 |
|
| 2011 |
Qu C, King T, Okun A, Lai J, Fields HL, Porreca F. Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy. Pain. 152: 1641-8. PMID 21474245 DOI: 10.1016/J.Pain.2011.03.002 |
0.834 |
|
| 2011 |
De Felice M, Ossipov MH, Porreca F. Persistent medication-induced neural adaptations, descending facilitation, and medication overuse headache. Current Opinion in Neurology. 24: 193-6. PMID 21467931 DOI: 10.1097/WCO.0b013e328346af25 |
0.373 |
|
| 2011 |
Meng ID, Dodick D, Ossipov MH, Porreca F. Pathophysiology of medication overuse headache: insights and hypotheses from preclinical studies. Cephalalgia : An International Journal of Headache. 31: 851-60. PMID 21444643 DOI: 10.1177/0333102411402367 |
0.388 |
|
| 2011 |
Ballet S, Feytens D, Buysse K, Chung NN, Lemieux C, Tumati S, Keresztes A, Van Duppen J, Lai J, Varga E, Porreca F, Schiller PW, Vanden Broeck J, Tourwé D. Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist. Journal of Medicinal Chemistry. 54: 2467-76. PMID 21413804 DOI: 10.1021/jm1016285 |
0.444 |
|
| 2011 |
Stagg NJ, Mata HP, Ibrahim MM, Henriksen EJ, Porreca F, Vanderah TW, Philip Malan T. Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids. Anesthesiology. 114: 940-8. PMID 21386701 DOI: 10.1097/Aln.0B013E318210F880 |
0.654 |
|
| 2011 |
Yamamoto T, Nair P, Largent-Milnes TM, Jacobsen NE, Davis P, Ma SW, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies. Journal of Medicinal Chemistry. 54: 2029-38. PMID 21366266 DOI: 10.1021/Jm101023R |
0.826 |
|
| 2011 |
Vera-Portocarrero LP, Ossipov MH, Lai J, King T, Porreca F. Descending facilitatory pathways from the rostroventromedial medulla mediate naloxone-precipitated withdrawal in morphine-dependent rats. The Journal of Pain : Official Journal of the American Pain Society. 12: 667-76. PMID 21354865 DOI: 10.1016/J.Jpain.2010.12.007 |
0.527 |
|
| 2011 |
Hildebrand ME, Smith PL, Bladen C, Eduljee C, Xie JY, Chen L, Fee-Maki M, Doering CJ, Mezeyova J, Zhu Y, Belardetti F, Pajouhesh H, Parker D, Arneric SP, Parmar M, ... Porreca F, et al. A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain. Pain. 152: 833-43. PMID 21349638 DOI: 10.1016/J.Pain.2010.12.035 |
0.726 |
|
| 2011 |
Liu P, Okun A, Ren J, Guo RC, Ossipov MH, Xie J, King T, Porreca F. Ongoing pain in the MIA model of osteoarthritis. Neuroscience Letters. 493: 72-5. PMID 21241772 DOI: 10.1016/J.Neulet.2011.01.027 |
0.831 |
|
| 2011 |
Okun A, DeFelice M, Eyde N, Ren J, Mercado R, King T, Porreca F. Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents. Molecular Pain. 7: 4. PMID 21219650 DOI: 10.1186/1744-8069-7-4 |
0.844 |
|
| 2011 |
Lee YS, Kulkarani V, Cowell SM, Ma SW, Davis P, Hanlon KE, Vanderah TW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of potent μ and δ opioid agonists with high lipophilicity. Journal of Medicinal Chemistry. 54: 382-6. PMID 21128594 DOI: 10.1021/Jm100982D |
0.825 |
|
| 2011 |
De Felice M, Ossipov MH, Porreca F. Update on medication-overuse headache. Current Pain and Headache Reports. 15: 79-83. PMID 21058047 DOI: 10.1007/s11916-010-0155-1 |
0.306 |
|
| 2011 |
Yan J, Edelmayer RM, Wei X, De Felice M, Porreca F, Dussor G. Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache. Pain. 152: 106-13. PMID 20971560 DOI: 10.1016/J.Pain.2010.09.036 |
0.775 |
|
| 2011 |
Raffa RB, Porreca F. The pain chronicles Journal of Clinical Investigation. 121: 825-825. DOI: 10.1172/JCI45953 |
0.432 |
|
| 2011 |
Ballet S, Frankiewicz L, Guillemyn K, van den Eynde I, Chung NN, Keresztes A, Van Duppen J, Lai J, Varga E, Porreca F, Schiller PW, Vanden Broeck J, Tourwé D. Evaluation of constrained amino acids in the design of neurokinin 1 receptor- and bifunctional opioid – neurokinin 1 receptor ligands Pharmacological Reports. 63: 229. DOI: 10.1016/S1734-1140(11)70448-0 |
0.395 |
|
| 2011 |
Tillu D, Asiedu M, Melemedjian O, Shy A, Bodell B, Sanoja R, Porreca F, Price T. Latent nociceptive sensitization requires the maintenance mechanism of LTP The Journal of Pain. 12: P33. DOI: 10.1016/J.Jpain.2011.02.133 |
0.729 |
|
| 2010 |
Ossipov MH, Dussor GO, Porreca F. Central modulation of pain. The Journal of Clinical Investigation. 120: 3779-87. PMID 21041960 DOI: 10.1172/JCI43766 |
0.674 |
|
| 2010 |
Largent-Milnes TM, Yamamoto T, Nair P, Moulton JW, Hruby VJ, Lai J, Porreca F, Vanderah TW. Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. British Journal of Pharmacology. 161: 986-1001. PMID 20977451 DOI: 10.1111/J.1476-5381.2010.00824.X |
0.864 |
|
| 2010 |
Weinreb PH, Wen D, Qian F, Wildes CP, Garber EA, Walus L, Jung MY, Wang J, Relton JK, Amatucci J, Wang R, Porreca F, Silvian L, Meier W, Pepinsky RB, et al. Resolution of disulfide heterogeneity in Nogo receptor I fusion proteins by molecular engineering. Biotechnology and Applied Biochemistry. 57: 31-45. PMID 20815818 DOI: 10.1042/Ba20100061 |
0.545 |
|
| 2010 |
Lian B, Vera-Portocarrero L, King T, Ossipov MH, Porreca F. Opioid-induced latent sensitization in a model of non-inflammatory viscerosomatic hypersensitivity. Brain Research. 1358: 64-70. PMID 20727859 DOI: 10.1016/J.Brainres.2010.08.032 |
0.515 |
|
| 2010 |
Giordano C, Sansone A, Masi A, Lucente G, Punzi P, Mollica A, Pinnen F, Feliciani F, Cacciatore I, Davis P, Lai J, Ma SW, Porreca F, Hruby V. Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. European Journal of Medicinal Chemistry. 45: 4594-600. PMID 20692738 DOI: 10.1016/J.Ejmech.2010.07.022 |
0.424 |
|
| 2010 |
De Felice M, Ossipov MH, Wang R, Dussor G, Lai J, Meng ID, Chichorro J, Andrews JS, Rakhit S, Maddaford S, Dodick D, Porreca F. Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers. Brain : a Journal of Neurology. 133: 2475-88. PMID 20627971 DOI: 10.1093/Brain/Awq159 |
0.683 |
|
| 2010 |
Yamamoto T, Nair P, Jacobsen NE, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines. Journal of Medicinal Chemistry. 53: 5491-501. PMID 20617791 DOI: 10.1021/Jm100157M |
0.746 |
|
| 2010 |
Vardanyan M, Melemedjian OK, Price TJ, Ossipov MH, Lai J, Roberts E, Boos TL, Deschamps JR, Jacobson AE, Rice KC, Porreca F. Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain. 151: 257-65. PMID 20599324 DOI: 10.1016/J.Pain.2010.05.022 |
0.808 |
|
| 2010 |
Lee YS, Fernandes S, Kulkarani V, Mayorov A, Davis P, Ma SW, Brown K, Gillies RJ, Lai J, Porreca F, Hruby VJ. Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain. Bioorganic & Medicinal Chemistry Letters. 20: 4080-4. PMID 20547453 DOI: 10.1016/J.Bmcl.2010.05.078 |
0.46 |
|
| 2010 |
Chen Q, Vera-Portocarrero LP, Ossipov MH, Vardanyan M, Lai J, Porreca F. Attenuation of persistent experimental pancreatitis pain by a bradykinin b2 receptor antagonist. Pancreas. 39: 1220-5. PMID 20531238 DOI: 10.1097/Mpa.0B013E3181Df1C90 |
0.813 |
|
| 2010 |
Torino D, Mollica A, Pinnen F, Feliciani F, Lucente G, Fabrizi G, Portalone G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues. Journal of Medicinal Chemistry. 53: 4550-4. PMID 20476738 DOI: 10.1021/Jm1001343 |
0.375 |
|
| 2010 |
De Felice M, Ossipov MH, Wang R, Lai J, Chichorro J, Meng I, Dodick DW, Vanderah TW, Dussor G, Porreca F. Triptan-induced latent sensitization: a possible basis for medication overuse headache. Annals of Neurology. 67: 325-37. PMID 20373344 DOI: 10.1002/Ana.21897 |
0.761 |
|
| 2010 |
Pajouhesh H, Feng ZP, Ding Y, Zhang L, Pajouhesh H, Morrison JL, Belardetti F, Tringham E, Simonson E, Vanderah TW, Porreca F, Zamponi GW, Mitscher LA, Snutch TP. Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 1378-83. PMID 20117000 DOI: 10.1016/J.Bmcl.2010.01.008 |
0.681 |
|
| 2010 |
Lipman AG, Beaulieu P, Lussier D, Porreca F, Dickinson AH. Pharmacology of pain Journal of Pain & Palliative Care Pharmacotherapy. 24: 179-179. DOI: 10.3109/15360288.2010.483271 |
0.34 |
|
| 2010 |
King T, Vera-Portocarrero L, Gutierrez T, Vanderah TW, Dussor G, Lai J, Fields HL, Porreca F. Erratum: Corrigendum: Unmasking the tonic-aversive state in neuropathic pain Nature Neuroscience. 13: 1033-1033. DOI: 10.1038/Nn0810-1033B |
0.743 |
|
| 2010 |
Ossipov MH, Porreca F. Neuropathic Pain: Basic Mechanisms (Animal) The Senses: a Comprehensive Reference. 5: 833-855. DOI: 10.1016/B978-012370880-9.00200-0 |
0.329 |
|
| 2010 |
ANANTHAN S, JOHNSON CA, CARTER RL, CLAYTON SD, RICE KC, XU H, DAVIS P, PORRECA F, ROTHMAN RB. ChemInform Abstract: Synthesis, Opioid Receptor Binding, and Bioassay of Naltrindole Analogues Substituted in the Indolic Benzene Moiety. Cheminform. 29: no-no. DOI: 10.1002/CHIN.199846254 |
0.301 |
|
| 2010 |
LIAO S, LIN J, SHENDEROVICH MD, HAN Y, HASOHATA K, DAVIS P, QIU W, PORRECA F, YAMAMURA HI, HRUBY VJ. ChemInform Abstract: The Stereochemical Requirements of the Novel δ-Opioid Selective Dipeptide Antagonist TMT-TIC. Cheminform. 29: no-no. DOI: 10.1002/CHIN.199812174 |
0.509 |
|
| 2010 |
HRUBY VJ, DAVIS TP, O'BRIEN DF, PORRECA F, YAMAMURA HI. ChemInform Abstract: Design of Peptides and Peptidomimetics That Are Selective, Stable and Can Cross Membrane Barriers Cheminform. 28: no-no. DOI: 10.1002/CHIN.199740331 |
0.346 |
|
| 2009 |
Yamamoto T, Nair P, Jacobsen NE, Vagner J, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 52: 5164-75. PMID 20560643 DOI: 10.1021/Jm900473P |
0.69 |
|
| 2009 |
Okada-Ogawa A, Porreca F, Meng ID. Sustained morphine-induced sensitization and loss of diffuse noxious inhibitory controls in dura-sensitive medullary dorsal horn neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15828-35. PMID 20016098 DOI: 10.1523/JNEUROSCI.3623-09.2009 |
0.427 |
|
| 2009 |
King T, Vera-Portocarrero L, Gutierrez T, Vanderah TW, Dussor G, Lai J, Fields HL, Porreca F. Unmasking the tonic-aversive state in neuropathic pain. Nature Neuroscience. 12: 1364-6. PMID 19783992 DOI: 10.1038/Nn.2407 |
0.755 |
|
| 2009 |
Yamamoto T, Nair P, Ma SW, Davis P, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety. Bioorganic & Medicinal Chemistry. 17: 7337-43. PMID 19762245 DOI: 10.1016/J.Bmc.2009.08.035 |
0.702 |
|
| 2009 |
Roberts J, Ossipov MH, Porreca F. Glial activation in the rostroventromedial medulla promotes descending facilitation to mediate inflammatory hypersensitivity. The European Journal of Neuroscience. 30: 229-41. PMID 19614984 DOI: 10.1111/J.1460-9568.2009.06813.X |
0.651 |
|
| 2009 |
Torino D, Mollica A, Pinnen F, Lucente G, Feliciani F, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue. Bioorganic & Medicinal Chemistry Letters. 19: 4115-8. PMID 19560919 DOI: 10.1016/J.Bmcl.2009.06.008 |
0.31 |
|
| 2009 |
Vardanyan R, Vijay G, Nichol GS, Liu L, Kumarasinghe I, Davis P, Vanderah T, Porreca F, Lai J, Hruby VJ. Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain. Bioorganic & Medicinal Chemistry. 17: 5044-53. PMID 19540763 DOI: 10.1016/J.Bmc.2009.05.065 |
0.664 |
|
| 2009 |
De Felice M, Porreca F. Opiate-induced persistent pronociceptive trigeminal neural adaptations: potential relevance to opiate-induced medication overuse headache. Cephalalgia : An International Journal of Headache. 29: 1277-84. PMID 19438917 DOI: 10.1111/j.1468-2982.2009.01873.x |
0.476 |
|
| 2009 |
Dogrul A, Ossipov MH, Porreca F. Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors. Brain Research. 1280: 52-9. PMID 19427839 DOI: 10.1016/j.brainres.2009.05.001 |
0.41 |
|
| 2009 |
Nair P, Yamamoto T, Kulkarni V, Moye S, Navratilova E, Davis P, Largent T, Ma SW, Yamamura HI, Vanderah T, Lai J, Porreca F, Hruby VJ. Novel bifunctional peptides as opioid agonists and NK-1 antagonists. Advances in Experimental Medicine and Biology. 611: 537-8. PMID 19400302 DOI: 10.1007/978-0-387-73657-0_235 |
0.751 |
|
| 2009 |
Lee Y, Petrov R, Kulkarni V, Min BJ, Ma SW, Davis P, Oyarzo J, Vanderah T, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety. Advances in Experimental Medicine and Biology. 611: 517-8. PMID 19400292 DOI: 10.1007/978-0-387-73657-0_225 |
0.617 |
|
| 2009 |
Kulkarni VV, Lee YS, Salibay C, Davis P, Ma SW, Porreca F, Hruby VJ. Novel analogues of bifunctional ligands for opioid and melanocortin 4 receptor. Advances in Experimental Medicine and Biology. 611: 195-6. PMID 19400157 DOI: 10.1007/978-0-387-73657-0_90 |
0.439 |
|
| 2009 |
Porreca F, Ossipov MH. Nausea and vomiting side effects with opioid analgesics during treatment of chronic pain: mechanisms, implications, and management options. Pain Medicine (Malden, Mass.). 10: 654-62. PMID 19302436 DOI: 10.1111/j.1526-4637.2009.00583.x |
0.494 |
|
| 2009 |
Edelmayer RM, Vanderah TW, Majuta L, Zhang ET, Fioravanti B, De Felice M, Chichorro JG, Ossipov MH, King T, Lai J, Kori SH, Nelsen AC, Cannon KE, Heinricher MM, Porreca F. Medullary pain facilitating neurons mediate allodynia in headache-related pain. Annals of Neurology. 65: 184-93. PMID 19259966 DOI: 10.1002/Ana.21537 |
0.832 |
|
| 2009 |
Rivat C, Vera-Portocarrero LP, Ibrahim MM, Mata HP, Stagg NJ, De Felice M, Porreca F, Malan TP. Spinal NK-1 receptor-expressing neurons and descending pathways support fentanyl-induced pain hypersensitivity in a rat model of postoperative pain. The European Journal of Neuroscience. 29: 727-37. PMID 19200067 DOI: 10.1111/J.1460-9568.2009.06616.X |
0.53 |
|
| 2009 |
Porreca F, Vanderah TW. Spring pain research conference 2008. Brain Research Reviews. 60: 1. PMID 19150467 DOI: 10.1016/j.brainresrev.2008.12.022 |
0.615 |
|
| 2009 |
Zhang W, Gardell S, Zhang D, Xie JY, Agnes RS, Badghisi H, Hruby VJ, Rance N, Ossipov MH, Vanderah TW, Porreca F, Lai J. Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors. Brain : a Journal of Neurology. 132: 778-87. PMID 19050032 DOI: 10.1093/Brain/Awn330 |
0.776 |
|
| 2009 |
Vardanyan A, Wang R, Vanderah TW, Ossipov MH, Lai J, Porreca F, King T. TRPV1 receptor in expression of opioid-induced hyperalgesia. The Journal of Pain : Official Journal of the American Pain Society. 10: 243-52. PMID 18774343 DOI: 10.1016/J.Jpain.2008.07.004 |
0.833 |
|
| 2009 |
Porreca F, Price T. When Pain Lingers Scientific American Mind. 20: 34-41. DOI: 10.1038/SCIENTIFICAMERICANMIND0909-34 |
0.576 |
|
| 2009 |
Basbaum AI, Braz J, Ossipov MH, Porreca F. The Endogenous Neuromodulation System Neuromodulation. 1: 303-312. DOI: 10.1016/B978-0-12-374248-3.00023-9 |
0.57 |
|
| 2009 |
Lai J, Wang R, Porreca F. Spinal dynorphin and neuropathic pain Synaptic Plasticity in Pain. 353-366. DOI: 10.1007/978-1-4419-0226-9_16 |
0.611 |
|
| 2008 |
Fioravanti B, De Felice M, Stucky CL, Medler KA, Luo MC, Gardell LR, Ibrahim M, Malan TP, Yamamura HI, Ossipov MH, King T, Lai J, Porreca F, Vanderah TW. Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11593-602. PMID 18987195 DOI: 10.1523/Jneurosci.3322-08.2008 |
0.823 |
|
| 2008 |
Luo MC, Chen Q, Ossipov MH, Rankin DR, Porreca F, Lai J. Spinal dynorphin and bradykinin receptors maintain inflammatory hyperalgesia. The Journal of Pain : Official Journal of the American Pain Society. 9: 1096-105. PMID 18976961 DOI: 10.1016/J.Jpain.2008.06.005 |
0.644 |
|
| 2008 |
King TE, Pawar SC, Majuta L, Sroka IC, Wynn D, Demetriou MC, Nagle RB, Porreca F, Cress AE. The role of alpha 6 integrin in prostate cancer migration and bone pain in a novel xenograft model. Plos One. 3: e3535. PMID 18958175 DOI: 10.1371/Journal.Pone.0003535 |
0.349 |
|
| 2008 |
Yamamoto T, Nair P, Jacobsen NE, Davis P, Ma SW, Navratilova E, Moye S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 6334-47. PMID 18821747 DOI: 10.1021/Jm800389V |
0.689 |
|
| 2008 |
Vera-Portocarrero LP, Ossipov MH, King T, Porreca F. Reversal of inflammatory and noninflammatory visceral pain by central or peripheral actions of sumatriptan. Gastroenterology. 135: 1369-78. PMID 18694754 DOI: 10.1053/J.Gastro.2008.06.085 |
0.408 |
|
| 2008 |
Agnes RS, Ying J, Kövér KE, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Peptides. 29: 1413-23. PMID 18502541 DOI: 10.1016/J.Peptides.2008.03.022 |
0.479 |
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| 2008 |
Lai J, Luo MC, Chen Q, Porreca F. Pronociceptive actions of dynorphin via bradykinin receptors. Neuroscience Letters. 437: 175-9. PMID 18450375 DOI: 10.1016/J.Neulet.2008.03.088 |
0.689 |
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| 2008 |
Wang R, King T, Ossipov MH, Rossomando AJ, Vanderah TW, Harvey P, Cariani P, Frank E, Sah DW, Porreca F. Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury. Nature Neuroscience. 11: 488-96. PMID 18344995 DOI: 10.1038/Nn2069 |
0.677 |
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| 2008 |
Vanderah TW, Largent-Milnes T, Lai J, Porreca F, Houghten RA, Menzaghi F, Wisniewski K, Stalewski J, Sueiras-Diaz J, Galyean R, Schteingart C, Junien JL, Trojnar J, Rivière PJ. Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors. European Journal of Pharmacology. 583: 62-72. PMID 18282565 DOI: 10.1016/J.Ejphar.2008.01.011 |
0.833 |
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| 2008 |
Yamamoto T, Nair P, Vagner J, Largent-Milnes T, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 1369-76. PMID 18266313 DOI: 10.1021/Jm070332F |
0.831 |
|
| 2008 |
Salvadori S, Fiorini S, Trapella C, Porreca F, Davis P, Sasaki Y, Ambo A, Marczak ED, Lazarus LH, Balboni G. Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorganic & Medicinal Chemistry. 16: 3032-8. PMID 18178091 DOI: 10.1016/j.bmc.2007.12.032 |
0.374 |
|
| 2008 |
Lee YS, Agnes RS, Cain JP, Kulkarni V, Cai M, Salibay C, Ciano K, Petrov R, Mayorov A, Vagner J, Trivedi D, Davis P, Ma SW, Lai J, Porreca F, et al. Opioid and melanocortin receptors: do they have overlapping pharmacophores? Biopolymers. 90: 433-8. PMID 17657709 DOI: 10.1002/Bip.20814 |
0.449 |
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| 2007 |
Khanolkar AD, Lu D, Ibrahim M, Duclos RI, Thakur GA, Malan TP, Porreca F, Veerappan V, Tian X, George C, Parrish DA, Papahatjis DP, Makriyannis A. Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity. Journal of Medicinal Chemistry. 50: 6493-500. PMID 18038967 DOI: 10.1021/Jm070441U |
0.374 |
|
| 2007 |
Muscoli C, Cuzzocrea S, Ndengele MM, Mollace V, Porreca F, Fabrizi F, Esposito E, Masini E, Matuschak GM, Salvemini D. Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice. The Journal of Clinical Investigation. 117: 3530-9. PMID 17975673 DOI: 10.1172/Jci32420 |
0.439 |
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| 2007 |
Lee YS, Petrov R, Park CK, Ma SW, Davis P, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. Journal of Medicinal Chemistry. 50: 5528-32. PMID 17927164 DOI: 10.1021/Jm061465O |
0.493 |
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| 2007 |
King T, Vardanyan A, Majuta L, Melemedjian O, Nagle R, Cress AE, Vanderah TW, Lai J, Porreca F. Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer. Pain. 132: 154-68. PMID 17706870 DOI: 10.1016/J.Pain.2007.06.026 |
0.837 |
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| 2007 |
Ossipov MH, Bazov I, Gardell LR, Kowal J, Yakovleva T, Usynin I, Ekström TJ, Porreca F, Bakalkin G. Control of chronic pain by the ubiquitin proteasome system in the spinal cord. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8226-37. PMID 17670969 DOI: 10.1523/Jneurosci.5126-06.2007 |
0.784 |
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| 2007 |
Mollica A, Guardiani G, Davis P, Ma SW, Porreca F, Lai J, Mannina L, Sobolev AP, Hruby VJ. Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. Journal of Medicinal Chemistry. 50: 3138-42. PMID 17539621 DOI: 10.1021/Jm061048B |
0.404 |
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| 2007 |
Yamamoto T, Nair P, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Vanderah TW, Yamamura HI, Porreca F, Hruby VJ. Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists. Journal of Medicinal Chemistry. 50: 2779-86. PMID 17516639 DOI: 10.1021/Jm061369N |
0.736 |
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| 2007 |
Dogrul A, Gülmez SE, Deveci MS, Gul H, Ossipov MH, Porreca F, Tulunay FC. The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test. Anesthesia and Analgesia. 104: 927-35. PMID 17377109 DOI: 10.1213/01.ane.0000258773.46897.34 |
0.407 |
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| 2007 |
Lee YS, Nyberg J, Moye S, Agnes RS, Davis P, Ma SW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors. Bioorganic & Medicinal Chemistry Letters. 17: 2161-5. PMID 17329100 DOI: 10.1016/J.Bmcl.2007.01.114 |
0.455 |
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| 2007 |
Lowery JJ, Yeomans L, Keyari CM, Davis P, Porreca F, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Glycosylation improves the central effects of DAMGO. Chemical Biology & Drug Design. 69: 41-7. PMID 17313456 DOI: 10.1111/J.1747-0285.2007.00462.X |
0.326 |
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| 2007 |
Martin TJ, Kim SA, Buechler NL, Porreca F, Eisenach JC. Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology. 106: 312-22. PMID 17264726 DOI: 10.1097/00000542-200702000-00020 |
0.493 |
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| 2007 |
Lee YS, Agnes RS, Davis P, Ma SW, Badghisi H, Lai J, Porreca F, Hruby VJ. Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. Journal of Medicinal Chemistry. 50: 165-8. PMID 17201419 DOI: 10.1021/Jm061268P |
0.464 |
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| 2007 |
Zhang ET, Ossipov MH, Zhang DQ, Lai J, Porreca F. Nerve injury-induced tactile allodynia is present in the absence of FOS labeling in retrogradely labeled post-synaptic dorsal column neurons. Pain. 129: 143-54. PMID 17156921 DOI: 10.1016/j.pain.2006.10.009 |
0.368 |
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| 2007 |
Vera-Portocarrero LP, Zhang ET, King T, Ossipov MH, Vanderah TW, Lai J, Porreca F. Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways. Pain. 129: 35-45. PMID 17123731 DOI: 10.1016/J.Pain.2006.09.033 |
0.664 |
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| 2007 |
Shinoda K, Hruby VJ, Porreca F. Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors. Neuroscience Letters. 411: 143-6. PMID 17110034 DOI: 10.1016/J.Neulet.2006.10.027 |
0.562 |
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| 2007 |
Chen Q, Cantu C, Lai J, Porreca F. (654) The Journal of Pain. 8: S14. DOI: 10.1016/J.Jpain.2007.02.065 |
0.482 |
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| 2007 |
Fioravanti B, Ibrahim M, Luo M, DeFelice M, Zhang W, Medler K, Stucky C, Malan T, Ossipov M, Lai J, Porreca F, Vanderah T. (641) The Journal of Pain. 8: S11. DOI: 10.1016/j.jpain.2007.02.052 |
0.526 |
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| 2006 |
Ossipov MH, Porreca F. Chapter 14 Descending excitatory systems. Handbook of Clinical Neurology. 81: 193-210. PMID 18808836 DOI: 10.1016/S0072-9752(06)80018-7 |
0.499 |
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| 2006 |
Ndungu JM, Cain JP, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Synthesis of constrained analogues of cholecystokinin/opioid chimeric peptides. Tetrahedron Letters. 47: 2233-2236. PMID 17203138 DOI: 10.1016/J.Tetlet.2006.01.096 |
0.607 |
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| 2006 |
Lai J, Luo MC, Chen Q, Ma S, Gardell LR, Ossipov MH, Porreca F. Dynorphin A activates bradykinin receptors to maintain neuropathic pain. Nature Neuroscience. 9: 1534-40. PMID 17115041 DOI: 10.1038/Nn1804 |
0.837 |
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| 2006 |
Hruby VJ, Porreca F, Yamamura HI, Tollin G, Agnes RS, Lee YS, Cai M, Alves I, Cowell S, Varga E, Davis P, Salamon Z, Roeske W, Vanderah T, Lai J. New paradigms and tools in drug design for pain and addiction. The Aaps Journal. 8: E450-60. PMID 17025262 DOI: 10.1208/Aapsj080353 |
0.733 |
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| 2006 |
Suzuki R, Porreca F, Dickenson AH. Evidence for spinal dorsal horn hyperexcitability in rats following sustained morphine exposure. Neuroscience Letters. 407: 156-61. PMID 16959420 DOI: 10.1016/J.Neulet.2006.08.027 |
0.504 |
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| 2006 |
Petrov RR, Vardanyan RS, Lee YS, Ma SW, Davis P, Begay LJ, Lai JY, Porreca F, Hruby VJ. Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity. Bioorganic & Medicinal Chemistry Letters. 16: 4946-50. PMID 16828552 DOI: 10.1016/J.Bmcl.2006.06.040 |
0.439 |
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| 2006 |
King T, Rao S, Vanderah T, Chen Q, Vardanyan A, Porreca F. Differential blockade of nerve injury-induced shift in weight bearing and thermal and tactile hypersensitivity by milnacipran. The Journal of Pain : Official Journal of the American Pain Society. 7: 513-20. PMID 16814690 DOI: 10.1016/J.Jpain.2006.02.001 |
0.768 |
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| 2006 |
Negri L, Lattanzi R, Giannini E, Colucci M, Margheriti F, Melchiorri P, Vellani V, Tian H, De Felice M, Porreca F. Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6716-27. PMID 16793879 DOI: 10.1523/JNEUROSCI.5403-05.2006 |
0.331 |
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| 2006 |
Vera-Portocarrero LP, Xie JY, Yie JX, Kowal J, Ossipov MH, King T, Porreca F. Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis. Gastroenterology. 130: 2155-64. PMID 16762636 DOI: 10.1053/J.Gastro.2006.03.025 |
0.658 |
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| 2006 |
Agnes RS, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Journal of Medicinal Chemistry. 49: 2868-75. PMID 16686530 DOI: 10.1021/Jm050921Q |
0.502 |
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| 2006 |
Vera-Portocarrero LP, Zhang ET, Ossipov MH, Xie JY, King T, Lai J, Porreca F. Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization. Neuroscience. 140: 1311-20. PMID 16650614 DOI: 10.1016/J.Neuroscience.2006.03.016 |
0.621 |
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| 2006 |
Amir R, Argoff CE, Bennett GJ, Cummins TR, Durieux ME, Gerner P, Gold MS, Porreca F, Strichartz GR. The role of sodium channels in chronic inflammatory and neuropathic pain. The Journal of Pain : Official Journal of the American Pain Society. 7: S1-29. PMID 16632328 DOI: 10.1016/J.Jpain.2006.01.444 |
0.379 |
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| 2006 |
Porreca F, Vanderah TW, Guo W, Barth M, Dodey P, Peyrou V, Luccarini JM, Junien JL, Pruneau D. Antinociceptive pharmacology of N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[[(4-methoxy-2,6-dimethylphenyl) sulfonyl]methylamino]ethoxy]-N-methylacetamide, fumarate (LF22-0542), a novel nonpeptidic bradykinin B1 receptor antagonist. The Journal of Pharmacology and Experimental Therapeutics. 318: 195-205. PMID 16565167 DOI: 10.1124/jpet.105.098368 |
0.661 |
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| 2006 |
Ibrahim MM, Rude ML, Stagg NJ, Mata HP, Lai J, Vanderah TW, Porreca F, Buckley NE, Makriyannis A, Malan TP. CB2 cannabinoid receptor mediation of antinociception. Pain. 122: 36-42. PMID 16563625 DOI: 10.1016/J.Pain.2005.12.018 |
0.646 |
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| 2006 |
Lee YS, Agnes RS, Badghisi H, Davis P, Ma SW, Lai J, Porreca F, Hruby VJ. Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. Journal of Medicinal Chemistry. 49: 1773-80. PMID 16509592 DOI: 10.1021/Jm050851N |
0.45 |
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| 2006 |
Gardell LR, King T, Ossipov MH, Rice KC, Lai J, Vanderah TW, Porreca F. Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery. Neuroscience Letters. 396: 44-9. PMID 16343768 DOI: 10.1016/J.Neulet.2005.11.009 |
0.839 |
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| 2006 |
Mollica A, Davis P, Ma SW, Porreca F, Lai J, Hruby VJ. Synthesis and biological activity of the first cyclic biphalin analogues. Bioorganic & Medicinal Chemistry Letters. 16: 367-72. PMID 16275086 DOI: 10.1016/J.Bmcl.2005.09.080 |
0.306 |
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| 2006 |
Vardanyan A, King T, Melemedjian O, Majuta L, Lai J, Porreca F. (330/631) The Journal of Pain. 7: S8. DOI: 10.1016/J.Jpain.2006.01.435 |
0.818 |
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| 2006 |
Ossipov MH, Porreca F. Chronic pain: multiple manifestations, multiple mechanisms Drug Discovery Today: Disease Mechanisms. 3: 301-303. DOI: 10.1016/j.ddmec.2006.09.008 |
0.425 |
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| 2006 |
Ibrahim M, Rude M, Stagg N, Mata H, Lai J, Vanderah T, Porreca F, Buckley N, Makriyannis A, Malan T. CB2 cannabinoid receptor mediation of antinociception Acute Pain. 8: 142. DOI: 10.1016/j.acpain.2006.08.026 |
0.564 |
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| 2006 |
Sah DYW, Porreca F, Ossipov MH. Modulation of neurotrophic growth factors as a therapeutic strategy for neuropathic pain Drug Development Research. 67: 389-403. DOI: 10.1002/ddr.20102 |
0.301 |
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| 2005 |
Ossipov MH, Porreca F. Challenges in the development of novel treatment strategies for neuropathic pain. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 2: 650-61. PMID 16489372 DOI: 10.1602/neurorx.2.4.650 |
0.454 |
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| 2005 |
Dogrul A, Bilsky EJ, Ossipov MH, Lai J, Porreca F. Spinal L-type calcium channel blockade abolishes opioid-induced sensory hypersensitivity and antinociceptive tolerance. Anesthesia and Analgesia. 101: 1730-5. PMID 16301251 DOI: 10.1213/01.ANE.0000184253.49849.B0 |
0.488 |
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| 2005 |
King T, Ossipov MH, Vanderah TW, Porreca F, Lai J. Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance? Neuro-Signals. 14: 194-205. PMID 16215302 DOI: 10.1159/000087658 |
0.729 |
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| 2005 |
Luo MC, Zhang DQ, Ma SW, Huang YY, Shuster SJ, Porreca F, Lai J. An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons. Molecular Pain. 1: 29. PMID 16191203 DOI: 10.1186/1744-8069-1-29 |
0.396 |
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| 2005 |
Svensson CI, Hua XY, Powell HC, Lai J, Porreca F, Yaksh TL. Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase. Neuropeptides. 39: 485-94. PMID 16176831 DOI: 10.1016/J.Npep.2005.08.002 |
0.406 |
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| 2005 |
Malan TP, Porreca F. Lipid mediators regulating pain sensitivity. Prostaglandins & Other Lipid Mediators. 77: 123-30. PMID 16099397 DOI: 10.1016/J.Prostaglandins.2004.09.008 |
0.429 |
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| 2005 |
Sah DW, Ossipov MH, Rossomando A, Silvian L, Porreca F. New approaches for the treatment of pain: the GDNF family of neurotrophic growth factors. Current Topics in Medicinal Chemistry. 5: 577-83. PMID 16022680 DOI: 10.2174/1568026054367593 |
0.402 |
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| 2005 |
King T, Gardell LR, Wang R, Vardanyan A, Ossipov MH, Malan TP, Vanderah TW, Hunt SP, Hruby VJ, Lai J, Porreca F. Role of NK-1 neurotransmission in opioid-induced hyperalgesia. Pain. 116: 276-88. PMID 15964684 DOI: 10.1016/J.Pain.2005.04.014 |
0.854 |
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| 2005 |
Mollica A, Davis P, Ma SW, Lai J, Porreca F, Hruby VJ. Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers. Bioorganic & Medicinal Chemistry Letters. 15: 2471-5. PMID 15863299 DOI: 10.1016/J.Bmcl.2005.03.067 |
0.36 |
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| 2005 |
Dhanasekaran M, Palian MM, Alves I, Yeomans L, Keyari CM, Davis P, Bilsky EJ, Egleton RD, Yamamura HI, Jacobsen NE, Tollin G, Hruby VJ, Porreca F, Polt R. Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers. Journal of the American Chemical Society. 127: 5435-48. PMID 15826181 DOI: 10.1021/Ja0432158 |
0.427 |
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| 2005 |
Ossipov MH, Lai J, King T, Vanderah TW, Porreca F. Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure. Biopolymers. 80: 319-24. PMID 15795927 DOI: 10.1002/Bip.20254 |
0.715 |
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| 2005 |
Ibrahim MM, Porreca F, Lai J, Albrecht PJ, Rice FL, Khodorova A, Davar G, Makriyannis A, Vanderah TW, Mata HP, Malan TP. CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proceedings of the National Academy of Sciences of the United States of America. 102: 3093-8. PMID 15705714 DOI: 10.1073/Pnas.0409888102 |
0.673 |
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| 2005 |
Varga EV, Hosohata K, Borys D, Navratilova E, Nylen A, Vanderah TW, Porreca F, Roeske WR, Yamamura HI. Antinociception depends on the presence of G protein gamma2-subunits in brain. European Journal of Pharmacology. 508: 93-8. PMID 15680258 DOI: 10.1016/J.Ejphar.2004.11.062 |
0.67 |
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| 2005 |
Gu X, Ying J, Min B, Cain JP, Davis P, Willey P, Navratilova E, Yamamura HI, Porreca F, Hruby VJ. Parallel synthesis and biological evaluation of different sizes of bicyclo[2,3]-Leu-enkephalin analogues. Biopolymers. 80: 151-63. PMID 15660379 DOI: 10.1002/Bip.20208 |
0.467 |
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| 2005 |
Xie JY, Herman DS, Stiller CO, Gardell LR, Ossipov MH, Lai J, Porreca F, Vanderah TW. Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 409-16. PMID 15647484 DOI: 10.1523/Jneurosci.4054-04.2005 |
0.86 |
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| 2005 |
Gavva NR, Tamir R, Qu Y, Klionsky L, Zhang TJ, Immke D, Wang J, Zhu D, Vanderah TW, Porreca F, Doherty EM, Norman MH, Wild KD, Bannon AW, Louis JC, et al. AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. The Journal of Pharmacology and Experimental Therapeutics. 313: 474-84. PMID 15615864 DOI: 10.1124/jpet.104.079855 |
0.654 |
|
| 2005 |
Egleton RD, Bilsky EJ, Tollin G, Dhanasekaran M, Lowery J, Alves I, Davis P, Porreca F, Yamamura HI, Yeomans L, Keyari CM, Polt R. Biousian glycopeptides penetrate the blood-brain barrier Tetrahedron Asymmetry. 16: 65-75. DOI: 10.1016/J.Tetasy.2004.11.038 |
0.501 |
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| 2005 |
Porreca F, Ossipov M, Munro F, Doris C, Morton R, Babul N. The opioid agonist TQ-1015 reverses mechanical allodynia and thermal hyperalgesia in carrageenan-induced inflammation The Journal of Pain. 6: S21. DOI: 10.1016/j.jpain.2005.01.080 |
0.332 |
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| 2005 |
Vera-Portocarrero L, King T, Vanderah T, Lai J, Porreca F. Ablation of NK-1 expressing cells in the spinal dorsal horn prevents the development of opioid-induced hyperalgesia and antinociceptive tolerance The Journal of Pain. 6: S17. DOI: 10.1016/J.Jpain.2005.01.065 |
0.631 |
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| 2004 |
Ossipov MH, Lai J, King T, Vanderah TW, Malan TP, Hruby VJ, Porreca F. Antinociceptive and nociceptive actions of opioids. Journal of Neurobiology. 61: 126-48. PMID 15362157 DOI: 10.1002/Neu.20091 |
0.704 |
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| 2004 |
Gu X, Ying J, Agnes RS, Navratilova E, Davis P, Stahl G, Porreca F, Yamamura HI, Hruby VJ. Novel design of bicyclic beta-turn dipeptides on solid-phase supports and synthesis of [3.3.0]-Bicyclo([2,3])-leu-enkephalin analogues. Organic Letters. 6: 3285-8. PMID 15355033 DOI: 10.1021/Ol0488183 |
0.494 |
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| 2004 |
Chen Q, King T, Vanderah TW, Ossipov MH, Malan TP, Lai J, Porreca F. Differential blockade of nerve injury-induced thermal and tactile hypersensitivity by systemically administered brain-penetrating and peripherally restricted local anesthetics. The Journal of Pain : Official Journal of the American Pain Society. 5: 281-9. PMID 15219260 DOI: 10.1016/J.Jpain.2004.05.002 |
0.678 |
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| 2004 |
Quartilho A, Mata HP, Ibrahim MM, Vanderah TW, Ossipov MH, Lai J, Porreca F, Malan TP. Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists. Anesthesiology. 100: 1538-44. PMID 15166576 DOI: 10.1097/00000542-200406000-00029 |
0.642 |
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| 2004 |
Elmagbari NO, Egleton RD, Palian MM, Lowery JJ, Schmid WR, Davis P, Navratilova E, Dhanasekaran M, Keyari CM, Yamamura HI, Porreca F, Hruby VJ, Polt R, Bilsky EJ. Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides. The Journal of Pharmacology and Experimental Therapeutics. 311: 290-7. PMID 15166257 DOI: 10.1124/Jpet.104.069393 |
0.566 |
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| 2004 |
Alves I, Cowell S, Lee YS, Tang X, Davis P, Porreca F, Hruby VJ. A novel 3-step enantioselective synthesis of pyrenylalanine with subsequent incorporation into opioid, CCK, and melanotropin ligands. Biochemical and Biophysical Research Communications. 318: 335-40. PMID 15120606 DOI: 10.1016/J.Bbrc.2004.04.033 |
0.354 |
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| 2004 |
Ananthan S, Khare NK, Saini SK, Seitz LE, Bartlett JL, Davis P, Dersch CM, Porreca F, Rothman RB, Bilsky EJ. Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone]. Journal of Medicinal Chemistry. 47: 1400-12. PMID 14998329 DOI: 10.1021/jm030311v |
0.417 |
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| 2004 |
Gavva NR, Klionsky L, Qu Y, Shi L, Tamir R, Edenson S, Zhang TJ, Viswanadhan VN, Toth A, Pearce LV, Vanderah TW, Porreca F, Blumberg PM, Lile J, Sun Y, et al. Molecular determinants of vanilloid sensitivity in TRPV1. The Journal of Biological Chemistry. 279: 20283-95. PMID 14996838 DOI: 10.1074/Jbc.M312577200 |
0.587 |
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| 2004 |
Wang ZQ, Porreca F, Cuzzocrea S, Galen K, Lightfoot R, Masini E, Muscoli C, Mollace V, Ndengele M, Ischiropoulos H, Salvemini D. A newly identified role for superoxide in inflammatory pain. The Journal of Pharmacology and Experimental Therapeutics. 309: 869-78. PMID 14988418 DOI: 10.1124/Jpet.103.064154 |
0.439 |
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| 2004 |
Koetzner L, Hua XY, Lai J, Porreca F, Yaksh T. Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 1451-8. PMID 14960618 DOI: 10.1523/JNEUROSCI.1517-03.2004 |
0.343 |
|
| 2004 |
Lai J, Porreca F, Hunter JC, Gold MS. Voltage-gated sodium channels and hyperalgesia. Annual Review of Pharmacology and Toxicology. 44: 371-97. PMID 14744251 DOI: 10.1146/annurev.pharmtox.44.101802.121627 |
0.395 |
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| 2004 |
Gardell LR, Ibrahim M, Wang R, Wang Z, Ossipov MH, Malan TP, Porreca F, Lai J. Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain. Neuroscience. 123: 43-52. PMID 14667440 DOI: 10.1016/J.Neuroscience.2003.08.021 |
0.8 |
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| 2004 |
Meng ID, Porreca F. Basic Science: Mechanisms of Medication Overuse Headache Headache Currents. 1: 47-54. DOI: 10.1111/J.1743-5013.2004.10110.X |
0.381 |
|
| 2004 |
Wang R, Guo W, Ossipov M, Vanderah T, Porreca F, Lai J. Erratum to “glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain” Neuroscience. 126: 247. DOI: 10.1016/J.Neuroscience.2004.03.032 |
0.649 |
|
| 2004 |
Gavva N, Klionsky L, Qu Y, Shi L, Tamir R, Edenson S, Zhang T, Viswanadhan V, Toth A, Vanderah T, Porreca F, Blumberg P, Lile J, Sun Y, Wild K, et al. Receptors and channels The Journal of Pain. 5: S6. DOI: 10.1016/j.jpain.2004.02.561 |
0.49 |
|
| 2003 |
Wang R, Guo W, Ossipov MH, Vanderah TW, Porreca F, Lai J. Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain. Neuroscience. 121: 815-24. PMID 14568039 DOI: 10.1016/S0306-4522(03)00491-3 |
0.74 |
|
| 2003 |
Gardell LR, Wang R, Ehrenfels C, Ossipov MH, Rossomando AJ, Miller S, Buckley C, Cai AK, Tse A, Foley SF, Gong B, Walus L, Carmillo P, Worley D, Huang C, ... ... Porreca F, et al. Multiple actions of systemic artemin in experimental neuropathy. Nature Medicine. 9: 1383-9. PMID 14528299 DOI: 10.1038/Nm944 |
0.832 |
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| 2003 |
Quartilho A, Mata HP, Ibrahim MM, Vanderah TW, Porreca F, Makriyannis A, Malan TP. Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors. Anesthesiology. 99: 955-60. PMID 14508331 DOI: 10.1097/00000542-200310000-00031 |
0.64 |
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| 2003 |
Dogrul A, Gardell LR, Ossipov MH, Tulunay FC, Lai J, Porreca F. Reversal of experimental neuropathic pain by T-type calcium channel blockers. Pain. 105: 159-68. PMID 14499432 DOI: 10.1016/S0304-3959(03)00177-5 |
0.746 |
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| 2003 |
Gardell LR, Vanderah TW, Gardell SE, Wang R, Ossipov MH, Lai J, Porreca F. Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8370-9. PMID 12967999 DOI: 10.1523/Jneurosci.23-23-08370.2003 |
0.825 |
|
| 2003 |
Ananthan S, Khare NK, Saini SK, Davis P, Dersch CM, Porreca F, Rothman RB. Novel ligands for the opioid receptors: synthesis and structure-activity relationships among 5'-aryl and 5'-heteroaryl 17-cyclopropylmethyl-4,5 alpha-epoxypyrido[2',3':6,7]morphinans. Bioorganic & Medicinal Chemistry. 11: 4143-54. PMID 12927876 DOI: 10.1016/S0968-0896(03)00432-2 |
0.405 |
|
| 2003 |
Ibrahim MM, Deng H, Zvonok A, Cockayne DA, Kwan J, Mata HP, Vanderah TW, Lai J, Porreca F, Makriyannis A, Malan TP. Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proceedings of the National Academy of Sciences of the United States of America. 100: 10529-33. PMID 12917492 DOI: 10.1073/Pnas.1834309100 |
0.691 |
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| 2003 |
Lai J, Hunter JC, Porreca F. The role of voltage-gated sodium channels in neuropathic pain. Current Opinion in Neurobiology. 13: 291-7. PMID 12850213 DOI: 10.1016/S0959-4388(03)00074-6 |
0.416 |
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| 2003 |
Ossipov MH, Lai J, Vanderah TW, Porreca F. Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance. Life Sciences. 73: 783-800. PMID 12801599 DOI: 10.1016/S0024-3205(03)00410-7 |
0.715 |
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| 2003 |
Hruby VJ, Agnes RS, Davis P, Ma SW, Lee YS, Vanderah TW, Lai J, Porreca F. Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain. Life Sciences. 73: 699-704. PMID 12801591 DOI: 10.1016/S0024-3205(03)00390-4 |
0.661 |
|
| 2003 |
Sah DW, Ossipo MH, Porreca F. Neurotrophic factors as novel therapeutics for neuropathic pain. Nature Reviews. Drug Discovery. 2: 460-72. PMID 12776221 DOI: 10.1038/nrd1107 |
0.455 |
|
| 2003 |
Ananthan S, Kezar HS, Saini SK, Khare NK, Davis P, Dersch CM, Porreca F, Rothman RB. Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans. Bioorganic & Medicinal Chemistry Letters. 13: 529-32. PMID 12565965 DOI: 10.1016/S0960-894X(02)00934-4 |
0.414 |
|
| 2003 |
Malan TP, Ibrahim MM, Lai J, Vanderah TW, Makriyannis A, Porreca F. CB2 cannabinoid receptor agonists: pain relief without psychoactive effects? Current Opinion in Pharmacology. 3: 62-7. PMID 12550743 DOI: 10.1016/S1471-4892(02)00004-8 |
0.69 |
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| 2003 |
Hosohata K, Varga EV, Alfaro-Lopez J, Tang X, Vanderah TW, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. (2S,3R) beta-methyl-2',6'-dimethyltyrosine-L-tetrahydroisoquinoline-3-carboxylic acid [(2S,3R)TMT-L-Tic-OH] is a potent, selective delta-opioid receptor antagonist in mouse brain. The Journal of Pharmacology and Experimental Therapeutics. 304: 683-8. PMID 12538822 DOI: 10.1124/Jpet.102.042929 |
0.649 |
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| 2003 |
Gold MS, Weinreich D, Kim CS, Wang R, Treanor J, Porreca F, Lai J. Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 158-66. PMID 12514212 DOI: 10.1523/Jneurosci.23-01-00158.2003 |
0.63 |
|
| 2002 |
Malan TP, Ibrahim MM, Vanderah TW, Makriyannis A, Porreca F. Inhibition of pain responses by activation of CB(2) cannabinoid receptors. Chemistry and Physics of Lipids. 121: 191-200. PMID 12505700 DOI: 10.1016/S0009-3084(02)00155-X |
0.688 |
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| 2002 |
Gardell LR, Ossipov MH, Vanderah TW, Lai J, Porreca F. Dynorphin-independent spinal cannabinoid antinociception. Pain. 100: 243-8. PMID 12467995 DOI: 10.1016/S0304-3959(02)00173-2 |
0.819 |
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| 2002 |
Dogrul A, Gardell LR, Ma S, Ossipov MH, Porreca F, Lai J. 'Knock-down' of spinal CB1 receptors produces abnormal pain and elevates spinal dynorphin content in mice. Pain. 100: 203-9. PMID 12435473 DOI: 10.1016/S0304-3959(02)00302-0 |
0.766 |
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| 2002 |
Ossipov MH, Zhang ET, Carvajal C, Gardell L, Quirion R, Dumont Y, Lai J, Porreca F. Selective mediation of nerve injury-induced tactile hypersensitivity by neuropeptide Y. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9858-67. PMID 12427842 DOI: 10.1523/Jneurosci.22-22-09858.2002 |
0.713 |
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| 2002 |
Gardell LR, Wang R, Burgess SE, Ossipov MH, Vanderah TW, Malan TP, Lai J, Porreca F. Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6747-55. PMID 12151554 DOI: 10.1523/Jneurosci.22-15-06747.2002 |
0.846 |
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| 2002 |
Gardell LR, Burgess SE, Dogrul A, Ossipov MH, Malan TP, Lai J, Porreca F. Pronociceptive effects of spinal dynorphin promote cannabinoid-induced pain and antinociceptive tolerance. Pain. 98: 79-88. PMID 12098619 DOI: 10.1016/S0304-3959(01)00475-4 |
0.79 |
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| 2002 |
Porreca F, Ossipov MH, Gebhart GF. Chronic pain and medullary descending facilitation. Trends in Neurosciences. 25: 319-25. PMID 12086751 DOI: 10.1016/S0166-2236(02)02157-4 |
0.467 |
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| 2002 |
Burgess SE, Gardell LR, Ossipov MH, Malan TP, Vanderah TW, Lai J, Porreca F. Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 5129-36. PMID 12077208 DOI: 10.1523/Jneurosci.22-12-05129.2002 |
0.825 |
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| 2002 |
Malan TP, Mata HP, Porreca F. Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain. Anesthesiology. 96: 1161-7. PMID 11981157 DOI: 10.1097/00000542-200205000-00020 |
0.445 |
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| 2002 |
Lai J, Gold MS, Kim CS, Bian D, Ossipov MH, Hunter JC, Porreca F. Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8. Pain. 95: 143-52. PMID 11790477 DOI: 10.1016/S0304-3959(01)00391-8 |
0.656 |
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| 2002 |
Burden JE, Davis P, Porreca F, Spatola AF. Synthesis and biological activities of YkFA analogues: effects of position 4 substitutions and altered ring size on in vitro opioid activity. Bioorganic & Medicinal Chemistry Letters. 12: 213-6. PMID 11755357 DOI: 10.1016/S0960-894X(01)00706-5 |
0.429 |
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| 2002 |
Quartilho A, Mata HP, Porreca F, Malan PT. Chronic Administration of a-2 Adrenoreceptor Agonists Produces Allodynia and Hyperalgesia Anesthesiology. 96: A951. DOI: 10.1097/00000542-200209002-00951 |
0.41 |
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| 2001 |
Ibrahim MM, Mata HP, Chawla M, Lai J, Porreca F, Malan TP. Allodynia and hyperalgesia produced by specific inhibition of spinal c-fos expression: lack of correlation with dynorphin content. The Journal of Pain : Official Journal of the American Pain Society. 2: 241-9. PMID 14622822 DOI: 10.1054/Jpai.2001.23135 |
0.368 |
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| 2001 |
Rasband MN, Park EW, Vanderah TW, Lai J, Porreca F, Trimmer JS. Distinct potassium channels on pain-sensing neurons. Proceedings of the National Academy of Sciences of the United States of America. 98: 13373-8. PMID 11698689 DOI: 10.1073/Pnas.231376298 |
0.565 |
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| 2001 |
Malan TP, Ibrahim MM, Deng H, Liu Q, Mata HP, Vanderah T, Porreca F, Makriyannis A. CB2 cannabinoid receptor-mediated peripheral antinociception. Pain. 93: 239-45. PMID 11514083 DOI: 10.1016/S0304-3959(01)00321-9 |
0.665 |
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| 2001 |
Porreca F, Burgess SE, Gardell LR, Vanderah TW, Malan TP, Ossipov MH, Lappi DA, Lai J. Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5281-8. PMID 11438603 DOI: 10.1523/Jneurosci.21-14-05281.2001 |
0.854 |
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| 2001 |
Simoneau II, Hamza MS, Mata HP, Siegel EM, Vanderah TW, Porreca F, Makriyannis A, Malan TP. The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets. Anesthesiology. 94: 882-7. PMID 11388542 DOI: 10.1097/00000542-200105000-00029 |
0.66 |
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| 2001 |
Liao S, Shenderovich M, Kövér KE, Zhang Z, Hosohata K, Davis P, Porreca F, Yamamura HI, Hurby VJ. Synthesis, biology, NMR and conformation studies of the topographically constrained delta-opioid selective peptide analogs of [beta-iPrPhe(3)]deltorphin I. The Journal of Peptide Research : Official Journal of the American Peptide Society. 57: 257-76. PMID 11328484 DOI: 10.1046/J.1397-002X.2000.00000.X |
0.521 |
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| 2001 |
Vanderah TW, Ossipov MH, Lai J, Malan TP, Porreca F. Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin. Pain. 92: 5-9. PMID 11323121 DOI: 10.1016/S0304-3959(01)00311-6 |
0.703 |
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| 2001 |
McLamore S, Ullrich T, Rothman RB, Xu H, Dersch C, Coop A, Davis P, Porreca F, Jacobson AE, Rice KC. Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy. Journal of Medicinal Chemistry. 44: 1471-4. PMID 11311071 DOI: 10.1021/Jm000511W |
0.378 |
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| 2001 |
Wang Z, Gardell LR, Ossipov MH, Vanderah TW, Brennan MB, Hochgeschwender U, Hruby VJ, Malan TP, Lai J, Porreca F. Pronociceptive actions of dynorphin maintain chronic neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1779-86. PMID 11222667 DOI: 10.1523/Jneurosci.21-05-01779.2001 |
0.819 |
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| 2001 |
Lipkowski AW, Misicka A, Hosohata K, Davis P, Yamamura HI, Porreca F, Hruby VJ. Biological properties of Phe(o)-opioid peptide analogues. Life Sciences. 68: 969-72. PMID 11213367 DOI: 10.1016/S0024-3205(00)00993-0 |
0.569 |
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| 2001 |
Sun H, Ren K, Zhong CM, Ossipov MH, Malan TP, Lai J, Porreca F. Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections. Pain. 90: 105-11. PMID 11166976 DOI: 10.1016/S0304-3959(00)00392-4 |
0.384 |
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| 2001 |
Vanderah TW, Suenaga NM, Ossipov MH, Malan TP, Lai J, Porreca F. Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 279-86. PMID 11150345 DOI: 10.1523/Jneurosci.21-01-00279.2001 |
0.711 |
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| 2000 |
Dogrul A, Ossipov MH, Lai J, Malan TP, Porreca F. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats. Neuroscience Letters. 292: 115-8. PMID 10998562 DOI: 10.1016/S0304-3940(00)01458-0 |
0.516 |
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| 2000 |
Vanderah TW, Gardell LR, Burgess SE, Ibrahim M, Dogrul A, Zhong CM, Zhang ET, Malan TP, Ossipov MH, Lai J, Porreca F. Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7074-9. PMID 10995854 DOI: 10.1523/Jneurosci.20-18-07074.2000 |
0.836 |
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| 2000 |
Kovelowski CJ, Ossipov MH, Sun H, Lai J, Malan TP, Porreca F. Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat. Pain. 87: 265-73. PMID 10963906 DOI: 10.1016/S0304-3959(00)00290-6 |
0.523 |
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| 2000 |
Furness MS, Zhang X, Coop A, Jacobson AE, Rothman RB, Dersch CM, Xu H, Porreca F, Rice KC. Probes for narcotic receptor-mediated phenomena. 27. Synthesis and pharmacological evaluation of selective delta-opioid receptor agonists from 4-[(alphaR)-alpha-(2S,5R)-4-substituted-2, 5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamides and their enantiomers. Journal of Medicinal Chemistry. 43: 3193-6. PMID 10956228 DOI: 10.1021/Jm0001222 |
0.316 |
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| 2000 |
Ossipov MH, Hong Sun T, Malan P, Lai J, Porreca F. Mediation of spinal nerve injury induced tactile allodynia by descending facilitatory pathways in the dorsolateral funiculus in rats. Neuroscience Letters. 290: 129-32. PMID 10936694 DOI: 10.1016/S0304-3940(00)01338-0 |
0.387 |
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| 2000 |
Ossipov MH, Jerussi TP, Ren K, Sun H, Porreca F. Differential effects of spinal (R)-ketoprofen and (S)-ketoprofen against signs of neuropathic pain and tonic nociception: evidence for a novel mechanism of action of (R)-ketoprofen against tactile allodynia. Pain. 87: 193-9. PMID 10924812 DOI: 10.1016/S0304-3959(00)00280-3 |
0.482 |
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| 2000 |
Ossipov MH, Lai J, Malan TP, Porreca F. Spinal and supraspinal mechanisms of neuropathic pain. Annals of the New York Academy of Sciences. 909: 12-24. PMID 10911921 DOI: 10.1111/J.1749-6632.2000.Tb06673.X |
0.522 |
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| 2000 |
Bilsky EJ, Egleton RD, Mitchell SA, Palian MM, Davis P, Huber JD, Jones H, Yamamura HI, Janders J, Davis TP, Porreca F, Hruby VJ, Polt R. Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability. Journal of Medicinal Chemistry. 43: 2586-90. PMID 10891118 DOI: 10.1021/Jm000077Y |
0.54 |
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| 2000 |
Tang Q, Lynch RM, Porreca F, Lai J. Dynorphin A elicits an increase in intracellular calcium in cultured neurons via a non-opioid, non-NMDA mechanism. Journal of Neurophysiology. 83: 2610-5. PMID 10805661 DOI: 10.1152/Jn.2000.83.5.2610 |
0.385 |
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| 2000 |
Malan TP, Ossipov MH, Gardell LR, Ibrahim M, Bian D, Lai J, Porreca F. Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats. Pain. 86: 185-94. PMID 10779675 DOI: 10.1016/S0304-3959(00)00243-8 |
0.802 |
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| 2000 |
Hosohata K, Logan JK, Varga E, Burkey TH, Vanderah TW, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. The role of the G protein gamma(2) subunit in opioid antinociception in mice. European Journal of Pharmacology. 392: R9-R11. PMID 10762674 DOI: 10.1016/S0014-2999(00)00132-1 |
0.633 |
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| 2000 |
Bonner GG, Davis P, Stropova D, Edsall S, Yamamura HI, Porreca F, Hruby VJ. Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays. Journal of Medicinal Chemistry. 43: 569-80. PMID 10691683 DOI: 10.1021/Jm9900218 |
0.508 |
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| 2000 |
Hosohata Y, Vanderah TW, Burkey TH, Ossipov MH, Kovelowski CJ, Sora I, Uhl GR, Zhang X, Rice KC, Roeske WR, Hruby VJ, Yamamura HI, Lai J, Porreca F. delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice. European Journal of Pharmacology. 388: 241-8. PMID 10675732 DOI: 10.1016/S0014-2999(99)00897-3 |
0.695 |
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| 2000 |
Lai J, Hunter JC, Ossipov MH, Porreca F. Blockade of neuropathic pain by antisense targeting of tetrodotoxin-resistant sodium channels in sensory neurons. Methods in Enzymology. 314: 201-13. PMID 10565014 DOI: 10.1016/S0076-6879(99)14104-1 |
0.46 |
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| 2000 |
Joshi SK, Su X, Porreca F, Gebhart GF. κ-Opioid Receptor Agonists Modulate Visceral Nociception at a Novel, Peripheral Site of Action The Journal of Neuroscience. 20: 5874-5879. DOI: 10.1523/Jneurosci.20-15-05874.2000 |
0.497 |
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| 1999 |
Zhang X, Rice KC, Calderon SN, Kayakiri H, Smith L, Coop A, Jacobson AE, Rothman RB, Davis P, Dersch CM, Porreca F. Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands. Journal of Medicinal Chemistry. 42: 5455-63. PMID 10639287 DOI: 10.1021/Jm9903895 |
0.353 |
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| 1999 |
Alfaro-Lopez J, Okayama T, Hosohata K, Davis P, Porreca F, Yamamura HI, Hruby VJ. Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand. Journal of Medicinal Chemistry. 42: 5359-68. PMID 10639279 DOI: 10.1021/Jm990337F |
0.529 |
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| 1999 |
Burden JE, Davis P, Porreca F, Spatola AF. Synthesis and biological activities of position one and three transposed analogs of the opioid peptide YKFA. Bioorganic & Medicinal Chemistry Letters. 9: 3441-6. PMID 10617088 DOI: 10.1016/S0960-894X(99)00625-3 |
0.442 |
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| 1999 |
Kovelowski CJ, Ossipov MH, Hruby VJ, Porreca F. Lesions of the dorsolateral funiculus block supraspinal opioid delta receptor mediated antinociception in the rat. Pain. 83: 115-22. PMID 10534582 DOI: 10.1016/S0304-3959(99)00083-4 |
0.527 |
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| 1999 |
Kovelowski CJ, Bian D, Hruby VJ, Lai J, Ossipov MH, Porreca F. Selective opioid delta agonists elicit antinociceptive supraspinal/spinal synergy in the rat. Brain Research. 843: 12-7. PMID 10528105 DOI: 10.1016/S0006-8993(99)01803-X |
0.668 |
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| 1999 |
Lipkowski AW, Misicka A, Davis P, Stropova D, Janders J, Lachwa M, Porreca F, Yamamura HI, Hruby VJ. Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin. Bioorganic & Medicinal Chemistry Letters. 9: 2763-6. PMID 10509931 DOI: 10.1016/S0960-894X(99)00464-3 |
0.546 |
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| 1999 |
Ananthan S, Kezar HS, Carter RL, Saini SK, Rice KC, Wells JL, Davis P, Xu H, Dersch CM, Bilsky EJ, Porreca F, Rothman RB. Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans. Journal of Medicinal Chemistry. 42: 3527-38. PMID 10479286 DOI: 10.1021/Jm990039I |
0.421 |
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| 1999 |
Lashbrook JM, Ossipov MH, Hunter JC, Raffa RB, Tallarida RJ, Porreca F. Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats. Pain. 82: 65-72. PMID 10422661 DOI: 10.1016/S0304-3959(99)00031-7 |
0.479 |
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| 1999 |
Bian D, Ossipov MH, Ibrahim M, Raffa RB, Tallarida RJ, Malan TP, Lai J, Porreca F. Loss of antiallodynic and antinociceptive spinal/supraspinal morphine synergy in nerve-injured rats: restoration by MK-801 or dynorphin antiserum. Brain Research. 831: 55-63. PMID 10411983 DOI: 10.1016/S0006-8993(99)01393-1 |
0.645 |
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| 1999 |
Porreca F, Lai J, Bian D, Wegert S, Ossipov MH, Eglen RM, Kassotakis L, Novakovic S, Rabert DK, Sangameswaran L, Hunter JC. A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain. Proceedings of the National Academy of Sciences of the United States of America. 96: 7640-4. PMID 10393873 DOI: 10.1073/pnas.96.14.7640 |
0.635 |
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| 1999 |
Wang Z, Bilsky EJ, Wang D, Porreca F, Sadée W. 3-Isobutyl-1-methylxanthine inhibits basal mu-opioid receptor phosphorylation and reverses acute morphine tolerance and dependence in mice. European Journal of Pharmacology. 371: 1-9. PMID 10355588 DOI: 10.1016/S0014-2999(99)00131-4 |
0.449 |
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| 1999 |
Bartosz-Bechowski H, Davis P, Slaninova J, Malatynska E, Stropova D, Porreca F, Yamamura HI, Hruby VJ. Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and metenkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for delta opioid receptors. The Journal of Peptide Research : Official Journal of the American Peptide Society. 53: 329-36. PMID 10231722 DOI: 10.1034/J.1399-3011.1999.00033.X |
0.52 |
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| 1999 |
Coop A, Rothman RB, Dersch C, Partilla J, Porreca F, Davis P, Jacobson AE, Rice KC. delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole. Journal of Medicinal Chemistry. 42: 1673-9. PMID 10229636 DOI: 10.1021/Jm9807003 |
0.432 |
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| 1999 |
Ossipov MH, Bian D, Malan TP, Lai J, Porreca F. Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats. Pain. 79: 127-33. PMID 10068158 DOI: 10.1016/S0304-3959(98)00187-0 |
0.6 |
|
| 1998 |
Vanderah TW, Raffa RB, Lashbrook J, Burritt A, Hruby V, Porreca F. Orphanin-FQ/nociceptin: lack of anti nociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats. European Journal of Pain (London, England). 2: 267-78. PMID 15102387 DOI: 10.1016/S1090-3801(98)90023-4 |
0.627 |
|
| 1998 |
Kovelowski CJ, Raffa RB, Porreca F. Tramadol and its enantiomers differentially suppress c-fos-like immunoreactivity in rat brain and spinal cord following acute noxious stimulus. European Journal of Pain (London, England). 2: 211-9. PMID 15102381 DOI: 10.1016/S1090-3801(98)90017-9 |
0.409 |
|
| 1998 |
Li G, Haq W, Xiang L, Lou BS, Hughes R, De Leon IA, Davis P, Gillespie TJ, Romanowski M, Zhu X, Misicka A, Lipkowski AW, Porreca F, Davis TP, Yamamura HI, et al. Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide. Bioorganic & Medicinal Chemistry Letters. 8: 555-60. PMID 9871617 DOI: 10.1016/S0960-894X(98)00065-1 |
0.573 |
|
| 1998 |
Porreca F, Lai J, Malan TP. Can inflammation relieve pain? Nature Medicine. 4: 1359-60. PMID 9846566 DOI: 10.1038/3942 |
0.326 |
|
| 1998 |
Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI, Hruby VJ. De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor. Journal of Medicinal Chemistry. 41: 4767-76. PMID 9822547 DOI: 10.1021/Jm980374R |
0.588 |
|
| 1998 |
Martin TJ, Hairston CT, Lutz PO, Harris LS, Porreca F. Anti-allodynic actions of intravenous opioids in the nerve injured rat: potential utility of heroin and dihydroetorphine against neuropathic pain. European Journal of Pharmacology. 357: 25-32. PMID 9788770 DOI: 10.1016/S0014-2999(98)00531-7 |
0.508 |
|
| 1998 |
Ni Q, Xu H, Partilla JS, Rice KC, Matecka D, Calderon SN, Porreca F, Lai J, Schmidhammer H, Krassnig R, Rothman RB. Opioid peptide receptor studies. 9. Identification of a novel non-mu- non-delta-like opioid peptide binding site in rat brain. Peptides. 19: 1079-90. PMID 9700759 DOI: 10.1016/S0196-9781(98)00046-1 |
0.344 |
|
| 1998 |
Ananthan S, Johnson CA, Carter RL, Clayton SD, Rice KC, Xu H, Davis P, Porreca F, Rothman RB. Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety. Journal of Medicinal Chemistry. 41: 2872-81. PMID 9667975 DOI: 10.1021/Jm980083I |
0.435 |
|
| 1998 |
Porreca F, Tang QB, Bian D, Riedl M, Elde R, Lai J. Spinal opioid mu receptor expression in lumbar spinal cord of rats following nerve injury. Brain Research. 795: 197-203. PMID 9622629 DOI: 10.1016/S0006-8993(98)00292-3 |
0.67 |
|
| 1998 |
Burkey TH, Ehlert FJ, Hosohata Y, Quock RM, Cowell S, Hosohata K, Varga E, Stropova D, Li X, Slate C, Nagase H, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. The efficacy of delta-opioid receptor-selective drugs. Life Sciences. 62: 1531-6. PMID 9585131 DOI: 10.1016/S0024-3205(98)00102-7 |
0.49 |
|
| 1998 |
Bian D, Ossipov MH, Zhong C, Malan TP, Porreca F. Tactile allodynia, but not thermal hyperalgesia, of the hindlimbs is blocked by spinal transection in rats with nerve injury. Neuroscience Letters. 241: 79-82. PMID 9507925 DOI: 10.1016/S0304-3940(98)00051-2 |
0.598 |
|
| 1998 |
Xu H, Lu YF, Partilla JS, Pinto J, Calderon SN, Matecka D, Rice KC, Lai J, Porreca F, Ananthan S, Rothman RB. Opioid peptide receptor studies. 8. One of the mouse brain deltaNCX binding sites is similar to the cloned mouse opioid delta receptor: further evidence for heterogeneity of delta opioid receptors. Peptides. 19: 343-50. PMID 9493867 DOI: 10.1016/S0196-9781(97)00294-5 |
0.41 |
|
| 1998 |
Lu YF, Xu H, Liu-Chen LY, Chen C, Partilla JS, Brine GA, Carroll FI, Rice KC, Lai J, Porreca F, Sadee W, Rothman RB. Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor. Synapse (New York, N.Y.). 28: 117-24. PMID 9450512 DOI: 10.1002/(Sici)1098-2396(199802)28:2<117::Aid-Syn2>3.0.Co;2-E |
0.423 |
|
| 1998 |
Malan TPJ, Ibrahim M, Ossipov MH, Bian D, Chawla M, Porreca F. PERIPHERAL NERVE INJURY CAUSES MULTISEGMENTAL ALLODYNIA AND A MULTISEGMENTAL INCREASE IN SPINAL DYNORPHIN CONTENT Anesthesiology. 89: 754A. DOI: 10.1097/00000542-199809130-00060 |
0.559 |
|
| 1998 |
Vanderah TW, Raffa RB, Lashbrook J, Burritt A, Hruby V, Porreca F. Orphanin-fq/nociceptin: Lack of antinociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats European Journal of Pain. 2: 267-280. DOI: 10.1016/S1090-3801(98)90023-4 |
0.517 |
|
| 1998 |
Castex N, Levine B, Vanderah T, Junien J, Porreca F, Riviere P. Spinal and peripheral kappa and mu opioid receptor agonists inhibit the response to noxious colorectal distension (CRD) Gastroenterology. 114: A1134. DOI: 10.1016/S0016-5085(98)84609-X |
0.659 |
|
| 1997 |
Hruby VJ, Bartosz-Bechowski H, Davis P, Slaninova J, Zalewska T, Stropova D, Porreca F, Yamamura HI. Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors. Journal of Medicinal Chemistry. 40: 3957-62. PMID 9397176 DOI: 10.1021/Jm9704762 |
0.534 |
|
| 1997 |
Haaseth RC, Zalewska T, Davis P, Yamamura HI, Porreca F, Hruby VJ. Para-substituted phenylalanine-4 analogues of [L-Ala3]DPDPE: highly selective delta opioid receptor ligands. The Journal of Peptide Research : Official Journal of the American Peptide Society. 50: 171-7. PMID 9309580 DOI: 10.1111/J.1399-3011.1997.Tb01182.X |
0.581 |
|
| 1997 |
Katsura Y, Zhang X, Homma K, Rice KC, Calderon SN, Rothman RB, Yamamura HI, Davis P, Flippen-Anderson JL, Xu H, Becketts K, Foltz EJ, Porreca F. Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists. Journal of Medicinal Chemistry. 40: 2936-47. PMID 9288176 DOI: 10.1021/Jm970106D |
0.539 |
|
| 1997 |
Misicka A, Cavagnero S, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Synthesis and biological properties of beta-MePhe3 analogues of deltorphin I and dermenkephalin: influence of biased chi 1 Phe3 residues on peptide recognition for delta-opioid receptors. The Journal of Peptide Research : Official Journal of the American Peptide Society. 50: 48-54. PMID 9273887 DOI: 10.1111/J.1399-3011.1997.Tb00619.X |
0.522 |
|
| 1997 |
Laughlin TM, Vanderah TW, Lashbrook J, Nichols ML, Ossipov M, Porreca F, Wilcox GL. Spinally administered dynorphin A produces long-lasting allodynia: involvement of NMDA but not opioid receptors. Pain. 72: 253-60. PMID 9272810 DOI: 10.1016/S0304-3959(97)00046-8 |
0.697 |
|
| 1997 |
Kramer TH, Bartosz-Bechowski H, Davis P, Hruby VJ, Porreca F. Extraordinary potency of a novel delta opioid receptor agonist is due in part to increased efficacy. Life Sciences. 61: 129-35. PMID 9217271 DOI: 10.1016/S0024-3205(97)00367-6 |
0.351 |
|
| 1997 |
Wegert S, Ossipov MH, Nichols ML, Bian D, Vanderah TW, Malan TP, Porreca F. Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured rats. Pain. 71: 57-64. PMID 9200174 DOI: 10.1016/S0304-3959(97)03337-X |
0.716 |
|
| 1997 |
Quock RM, Hosohata Y, Knapp RJ, Burkey TH, Hosohata K, Zhang X, Rice KC, Nagase H, Hruby VJ, Porreca F, Roeske WR, Yamamura HI. Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor. European Journal of Pharmacology. 326: 101-4. PMID 9178661 DOI: 10.1016/S0014-2999(97)83488-7 |
0.561 |
|
| 1997 |
Patel D, McKinley BD, Davis TP, Porreca F, Yamamura HI, Hruby VJ. Peptide targeting and delivery across the blood-brain barrier utilizing synthetic triglyceride esters: design, synthesis, and bioactivity. Bioconjugate Chemistry. 8: 434-41. PMID 9177851 DOI: 10.1021/Bc970027G |
0.47 |
|
| 1997 |
Bonner GG, Davis P, Stropova D, Ferguson R, Yamamura HI, Porreca F, Hruby VJ. Opioid peptides: simultaneous delta agonism and mu antagonism in somatostatin analogues. Peptides. 18: 93-100. PMID 9114458 DOI: 10.1016/S0196-9781(96)00242-2 |
0.606 |
|
| 1997 |
Misicka A, Lipkowski AW, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4. Life Sciences. 60: 1263-9. PMID 9096243 DOI: 10.1016/S0024-3205(97)00069-6 |
0.562 |
|
| 1997 |
Nichols ML, Lopez Y, Ossipov MH, Bian D, Porreca F. Enhancement of the antiallodynic and antinociceptive efficacy of spinal morphine by antisera to dynorphin A (1-13) or MK-801 in a nerve-ligation model of peripheral neuropathy. Pain. 69: 317-22. PMID 9085307 DOI: 10.1016/S0304-3959(96)03282-4 |
0.67 |
|
| 1997 |
Calderon SN, Rice KC, Rothman RB, Porreca F, Flippen-Anderson JL, Kayakiri H, Xu H, Becketts K, Smith LE, Bilsky EJ, Davis P, Horvath R. Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid receptor ligands. Journal of Medicinal Chemistry. 40: 695-704. PMID 9057856 DOI: 10.1021/Jm960319N |
0.439 |
|
| 1997 |
Ossipov MH, Lopez Y, Bian D, Nichols ML, Porreca F. Synergistic antinociceptive interactions of morphine and clonidine in rats with nerve-ligation injury. Anesthesiology. 86: 196-204. PMID 9009955 DOI: 10.1097/00000542-199701000-00024 |
0.639 |
|
| 1997 |
Xu H, Lu Y, Partilla JS, Brine GA, Carroll FI, Rice KC, Lai J, Porreca F, Rothman RB. Opioid Peptide Receptor Studies. 6. The 3-Methylfentanyl Congeners RTI-4614-4 and Its Enantiomers Differ in Efficacy, Potency, and Intrinsic Efficacy as Measured by Stimulation of [35S]GTP-γ-S Binding Using Cloned μ-Opioid Receptors Analgesia. 3: 35-42. DOI: 10.3727/107156997819566037 |
0.336 |
|
| 1997 |
Liao S, Lin J, Shenderovich MD, Han Y, Hasohata K, Davis P, Qiu W, Porreca F, Yamamura HI, Hruby VJ. The stereochemical requirements of the novel δ-opioid selective dipeptide antagonist TMT-Tic Bioorganic & Medicinal Chemistry Letters. 7: 3049-3052. DOI: 10.1016/S0960-894X(97)10145-7 |
0.531 |
|
| 1997 |
Ossipov MH, Malan TP, Lai J, Porreca F. Opioid Pharmacology of Acute and Chronic Pain Handbook of Experimental Pharmacology. 130: 305-333. DOI: 10.1007/978-3-642-60777-6_12 |
0.555 |
|
| 1996 |
Mayfield KP, Kozak W, Malvin GM, Porreca F. Hypoxia decreases opioid delta receptor expression in mouse brain Neuroscience. 72: 785-789. PMID 9157323 DOI: 10.1016/0306-4522(95)00585-4 |
0.453 |
|
| 1996 |
Vanderah TW, Laughlin T, Lashbrook JM, Nichols ML, Wilcox GL, Ossipov MH, Malan TP, Porreca F. Single intrathecal injections of dynorphin A or des-Tyr-dynorphins produce long-lasting allodynia in rats: blockade by MK-801 but not naloxone. Pain. 68: 275-81. PMID 9121815 DOI: 10.1016/S0304-3959(96)03225-3 |
0.711 |
|
| 1996 |
Bilsky EJ, Inturrisi CE, Sadée W, Hruby VJ, Porreca F. Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective μ or δ opioid agonists in mice Pain. 68: 229-237. PMID 9121809 DOI: 10.1016/S0304-3959(96)03185-5 |
0.443 |
|
| 1996 |
Bilsky EJ, Wang T, Lai J, Porreca F. Selective blockade of peripheral delta opioid agonist induced antinociception by intrathecal administration of delta receptor antisense oligodeoxynucleotide. Neuroscience Letters. 220: 155-8. PMID 8994216 DOI: 10.1016/S0304-3940(96)13262-6 |
0.463 |
|
| 1996 |
Lai J, Ma SW, Porreca F, Raffa RB. Tramadol, M1 metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells. European Journal of Pharmacology. 316: 369-72. PMID 8982709 DOI: 10.1016/S0014-2999(96)00770-4 |
0.426 |
|
| 1996 |
Nichols ML, Bian D, Ossipov MH, Malan TP, Porreca F. Antiallodynic effects of a CCKB antagonist in rats with nerve ligation injury: role of endogenous enkephalins. Neuroscience Letters. 215: 161-4. PMID 8899738 DOI: 10.1016/0304-3940(96)12964-5 |
0.689 |
|
| 1996 |
Lai J, Riedl M, Stone LS, Arvidsson U, Bilsky EJ, Wilcox GL, Elde R, Porreca F. Immunofluorescence analysis of antisense oligodeoxynucleotide-mediated 'knock-down' of the mouse delta opioid receptor in vitro and in vivo. Neuroscience Letters. 213: 205-8. PMID 8873150 DOI: 10.1016/0304-3940(96)12883-4 |
0.45 |
|
| 1996 |
Zaki PA, Bilsky EJ, Vanderah TW, Lai J, Evans CJ, Porreca F. Opioid receptor types and subtypes: the delta receptor as a model. Annual Review of Pharmacology and Toxicology. 36: 379-401. PMID 8725395 DOI: 10.1146/Annurev.Pa.36.040196.002115 |
0.64 |
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| 1996 |
Lung FD, Meyer JP, Lou BS, Xiang L, Li G, Davis P, DeLeon IA, Yamamura HI, Porreca F, Hruby VJ. Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency. Journal of Medicinal Chemistry. 39: 2456-60. PMID 8691442 DOI: 10.1021/jm950655o |
0.513 |
|
| 1996 |
Tourwé D, Verschueren K, Frycia A, Davis P, Porreca F, Hruby VJ, Toth G, Jaspers H, Verheyden P, Van Binst G. Conformational restriction of Tyr and Phe side chains in opioid peptides: information about preferred and bioactive side-chain topology. Biopolymers. 38: 1-12. PMID 8679939 DOI: 10.1002/(Sici)1097-0282(199601)38:1<1::Aid-Bip1>3.0.Co;2-# |
0.318 |
|
| 1996 |
Lung FD, Collins N, Stropova D, Davis P, Yamamura HI, Porreca F, Hruby VJ. Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphine A(1-11)-NH2. Journal of Medicinal Chemistry. 39: 1136-41. PMID 8676350 DOI: 10.1021/Jm950369C |
0.564 |
|
| 1996 |
Ossipov MH, Kovelowski CJ, Nichols ML, Hruby VJ, Porreca F. Characterization of supraspinal antinociceptive actions of opioid delta agonists in the rat. Pain. 62: 287-93. PMID 8657428 DOI: 10.1016/0304-3959(94)00231-3 |
0.457 |
|
| 1996 |
Bertha CM, Ellis M, Flippen-Anderson JL, Porreca F, Rothman RB, Davis P, Xu H, Becketts K, Rice KC. Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity. Journal of Medicinal Chemistry. 39: 2081-6. PMID 8642567 DOI: 10.1021/Jm950695S |
0.399 |
|
| 1996 |
Cooper RA, de Freitas JC, Porreca F, Eisenhour CM, Lukas R, Huxtable RJ. The sea anemone purine, caissarone: adenosine receptor antagonism. Toxicon : Official Journal of the International Society On Toxinology. 33: 1025-31. PMID 8533136 DOI: 10.1016/0041-0101(95)00047-P |
0.367 |
|
| 1996 |
Bian D, Nichols ML, Ossipov MH, Porreca F. Antiallodynic Effects of Tramadol in a Model of Neuropathic Pain in Rats Analgesia. 2: 57-62. DOI: 10.3727/107156996819564841 |
0.338 |
|
| 1996 |
Qian X, Shenderovich MD, Kover KE, Davis P, Horvath R, Zalewska T, Yamamura HI, Porreca F, Hruby VJ. Probing the stereochemical requirements for receptor recognition of δ opioid agonists through topographic modifications in position 1 Journal of the American Chemical Society. 118: 7280-7290. DOI: 10.1021/Ja954241W |
0.539 |
|
| 1995 |
Lai J, Bilsky EJ, Porreca F. Treatment with antisense oligodeoxynucleotide to a conserved sequence of opioid receptors inhibits antinociceptive effects of delta subtype selective ligands Journal of Receptors and Signal Transduction. 15: 643-650. PMID 8903970 DOI: 10.3109/10799899509045246 |
0.337 |
|
| 1995 |
Rao RK, Lopez Y, Lai J, Riviere PJ, Junien JL, Porreca F. Attenuation of gastrin-induced gastric acid secretion by antisense oligonucleotide to the CCKB/gastrin receptor. Neuroreport. 6: 2373-7. PMID 8747156 DOI: 10.1097/00001756-199511270-00023 |
0.331 |
|
| 1995 |
Cha XY, Xu H, Ni Q, Partilla JS, Rice KC, Matecka D, Calderon SN, Porreca F, Lai J, Rothman RB. Opioid peptide receptor studies. 4. Antisense oligodeoxynucleotide to the delta opioid receptor delineates opioid receptor subtypes Regulatory Peptides. 59: 247-253. PMID 8584761 DOI: 10.1016/0167-0115(95)00095-S |
0.413 |
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| 1995 |
Ossipov MH, Lopez Y, Nichols ML, Bian D, Porreca F. The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive. Neuroscience Letters. 199: 87-90. PMID 8584250 DOI: 10.1016/0304-3940(95)12022-V |
0.653 |
|
| 1995 |
Ossipov MH, Lopez Y, Nichols ML, Bian D, Porreca F. Inhibition by spinal morphine of the tail-flick response is attenuated in rats with nerve ligation injury. Neuroscience Letters. 199: 83-6. PMID 8584249 DOI: 10.1016/0304-3940(95)12026-Z |
0.651 |
|
| 1995 |
Bian D, Nichols ML, Ossipov MH, Lai J, Porreca F. Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats. Neuroreport. 6: 1981-4. PMID 8580422 DOI: 10.1097/00001756-199510010-00007 |
0.714 |
|
| 1995 |
Lung FD, Meyer JP, Li G, Lou BS, Stropova D, Davis P, Yamamura HI, Porreca F, Hruby VJ. Highly kappa receptor-selective dynorphin A analogues with modifications in position 3 of dynorphin A(1-11)-NH2. Journal of Medicinal Chemistry. 38: 585-6. PMID 7861405 DOI: 10.1021/Jm00004A002 |
0.459 |
|
| 1995 |
Beutler AS, Banck MS, Bach FW, Gage FH, Porreca F, Bilsky EJ, Yaksh TL. Retrovirus-mediated expression of an artificial beta-endorphin precursor in primary fibroblasts. Journal of Neurochemistry. 64: 475-81. PMID 7830038 DOI: 10.1046/J.1471-4159.1995.64020475.X |
0.333 |
|
| 1995 |
Cha XY, Xu H, Rice KC, Porreca F, Lai J, Ananthan S, Rothman RB. Opioid peptide receptor studies. 1. Identification of a novel delta-opioid receptor binding site in rat brain membranes. Peptides. 16: 191-8. PMID 7784248 DOI: 10.1016/0196-9781(94)00182-0 |
0.37 |
|
| 1995 |
Bertha CM, Flippen-Anderson JL, Rothman RB, Porreca F, Davis P, Xu H, Becketts K, Cha XY, Rice KC. Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands. Journal of Medicinal Chemistry. 38: 1523-37. PMID 7739011 DOI: 10.1021/Jm00009A013 |
0.463 |
|
| 1995 |
Ossipov MH, Kovelowski CJ, Porreca F. The increase in morphine antinociceptive potency produced by carrageenan-induced hindpaw inflammation is blocked by naltrindole, a selective δ-opioid antagonist Neuroscience Letters. 184: 173-176. PMID 7715840 DOI: 10.1016/0304-3940(94)11199-S |
0.484 |
|
| 1995 |
Meyer JP, Davis P, Lee KB, Porreca F, Yamamura HI, Hruby VJ. Synthesis using a Fmoc-based strategy and biological activities of some reduced peptide bond pseudopeptide analogues of dynorphin A1. Journal of Medicinal Chemistry. 38: 3462-8. PMID 7658433 DOI: 10.1021/Jm00018A006 |
0.531 |
|
| 1995 |
Mayfield KP, Horvath R, Lai J, Porreca F. Increased expression of opioid delta receptors by deoxy conformation heme proteins in NG108-15 cells Brain Research. 676: 358-362. PMID 7614006 DOI: 10.1016/0006-8993(95)00089-9 |
0.318 |
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| 1995 |
Hruby VJ, Yamamura HI, Porreca F. Molecular organization of receptors. Efficacy, agonists, and antagonists. Annals of the New York Academy of Sciences. 757: 7-22. PMID 7611710 DOI: 10.1111/J.1749-6632.1995.Tb17461.X |
0.518 |
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| 1995 |
Reid LD, Glick SD, Menkens KA, French ED, Bilsky EJ, Porreca F. Cocaine self-administration and naltrindole, a delta-selective opioid antagonist Neuroreport. 6: 1409-1412. PMID 7488736 DOI: 10.1097/00001756-199507100-00012 |
0.344 |
|
| 1995 |
Misicka A, Lipkowski AW, Slaninova J, Davis P, Yamamura HI, Porreca F, Hruby VJ. The synthesis and opioid receptor binding affinities of analogues of dermorphin and its N-terminal tetrapeptide fragment with dibasic acids in position 2. Life Sciences. 57: 1633-40. PMID 7475903 DOI: 10.1016/0024-3205(95)02142-6 |
0.549 |
|
| 1995 |
Ni Q, Xu H, Partilla JS, Calderon SN, Porreca F, Rice KC, Bertha CM, McNutt RW, Ananthan S, Rothman RB. Opioid Peptide Receptor Studies 2. [3H]SNC-121, a Novel, Selective, and High-Affinity Ligand for Opioid Delta Receptors Analgesia. 1: 185-193. DOI: 10.3727/107156995819564239 |
0.339 |
|
| 1995 |
Lai J, Crook T, Payne A, Porreca F. ANTISENSE OLIGODEOXYNUCLEOTIDE-MEDIATED REDUCTION IN THE δ OPIOID RECEPTORS: DIRECT CORRELATION BETWEEN ANTISENSE UPTAKE AND RECEPTOR “KNOCK-DOWN" Analgesia. 1: 535-538. DOI: 10.3727/107156995819564121 |
0.313 |
|
| 1995 |
Vanderah TW, Bernstein RN, Lai J, Porreca F. PRODUCTION OF NALTRINDOLE-SENSITIVE ANTINOCICEPTION BY A CHOLECYSTOKININ (CCK) ANTAGONIST AND THIORPHAN: EVIDENCE FOR TONIC INHIBITION OF ENKEPHALIN RELEASE BY CCK Analgesia. 1: 813-816. DOI: 10.3727/107156995819563546 |
0.51 |
|
| 1995 |
Li X, Knapp RJ, Stropova D, Varga E, Wang Y, Malatynska E, Calderont S, Ricet K, Rothman R, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. Trp284 of the Human δ Opioid Receptor is Required for SNC121 Binding but Not Binding of pCl-DPDPE, Deltorphin II or Naltrindole Analgesia. 1: 539-542. DOI: 10.3727/107156995819563302 |
0.47 |
|
| 1995 |
Hruby VJ, Davis T, Polt R, Porreca F, O’Brien D, Yamamura H, Bartosz H, Szabo L, Gillespie T, Williams S, Misicka A, Lipkowski A, Qian X, Li G, Patel D, et al. DESIGN AND SYNTHESIS OF PEPTIDE LIGANDS WITH UNIQUE BIOCHEMICAL AND BIOLOGICAL PROFILES AT OPIOID RECEPTORS THAT CROSS THE BLOOD BRAIN BARRIER Analgesia. 1: 469-472. DOI: 10.3727/107156995819562961 |
0.47 |
|
| 1995 |
Cooper R, Freitas J, Porreca F, Eisenhour C, Lukas R, Huxtable R. Caissarone, a sea anemone purine, is an adenosine receptor antagonist Toxicon. 33: 278-279. DOI: 10.1016/0041-0101(95)99292-B |
0.353 |
|
| 1995 |
Misicka A, Lipkowski AW, Stropova D, Davis P, Porreca F, Yamamura HI, Hruby VJ. Amino acids with amphiphilic side chains: Deltorphin analogues with Phe3 replaced by all β-hydroxyphenylalanine diastereoisomers Letters in Peptide Science. 2: 203-205. DOI: 10.1007/Bf00119153 |
0.467 |
|
| 1995 |
Lipkowski AW, Misicka A, Porreca F, Davis P, Yamamura HI, Stropova D, Hruby VJ. Benzomorphan alkaloids: Natural peptidomimetics of opioid peptide pharmacophores Letters in Peptide Science. 2: 177-181. DOI: 10.1007/Bf00119147 |
0.559 |
|
| 1994 |
Bartosz-Bechowski H, Davis P, Zalewska T, Slaninova J, Porreca F, Yamamura HI, Hruby VJ. Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors. Journal of Medicinal Chemistry. 37: 146-50. PMID 8289188 DOI: 10.1021/Jm00027A018 |
0.583 |
|
| 1994 |
Misicka A, Lipkowski AW, Horvath R, Davis P, Yamamura HI, Porreca F, Hruby VJ. Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors. Journal of Medicinal Chemistry. 37: 141-5. PMID 8289187 DOI: 10.1021/Jm00027A017 |
0.556 |
|
| 1994 |
Haaseth RC, Horan PJ, Bilsky EJ, Davis P, Zalewska T, Slaninova J, Yamamura HI, Weber SJ, Davis TP, Porreca F. [L-Ala3]DPDPE: a new enkephalin analog with a unique opioid receptor activity profile. Further evidence of delta-opioid receptor multiplicity. Journal of Medicinal Chemistry. 37: 1572-7. PMID 8201592 DOI: 10.1021/Jm00037A007 |
0.567 |
|
| 1994 |
Vanderah T, Takemori AE, Sultana M, Portoghese PS, Mosberg HI, Hruby VJ, Haaseth RC, Matsunaga TO, Porreca F. Interaction of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes in vivo. European Journal of Pharmacology. 252: 133-7. PMID 8157053 DOI: 10.1016/0014-2999(94)90588-6 |
0.641 |
|
| 1994 |
Lai J, Bilsky EJ, Rothman RB, Porreca F. Treatment with antisense oligodeoxynucleotide to the opioid δ receptor selectively inhibits δ<inf>2</inf>-agonist antinociception Neuroreport. 5: 1049-1052. PMID 8080957 DOI: 10.1097/00001756-199405000-00008 |
0.443 |
|
| 1994 |
Polt R, Porreca F, Szabò LZ, Bilsky EJ, Davis P, Abbruscato TJ, Davis TP, Harvath R, Yamamura HI, Hruby VJ. Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America. 91: 7114-8. PMID 8041755 DOI: 10.1073/Pnas.91.15.7114 |
0.521 |
|
| 1994 |
Calderon SN, Rothman RB, Porreca F, Flippen-Anderson JL, McNutt RW, Xu H, Smith LE, Bilsky EJ, Davis P, Rice KC. Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist. Journal of Medicinal Chemistry. 37: 2125-8. PMID 8035418 DOI: 10.1021/Jm00040A002 |
0.346 |
|
| 1994 |
Qian X, Kövér KE, Shenderovich MD, Lou BS, Misicka A, Zalewska T, Horváth R, Davis P, Bilsky EJ, Porreca F, Yamamura HI, Hruby VJ. Newly discovered stereochemical requirements in the side-chain conformation of δ opioid agonists for recognizing opioid δ receptors Journal of Medicinal Chemistry. 37: 1746-1757. PMID 8021915 DOI: 10.1021/JM00038A004 |
0.541 |
|
| 1994 |
Bilsky EJ, Bernstein RN, Pasternak GW, Hruby VJ, Patel D, Porreca F, Lai J. Selective inhibition of [D-ALA2, GLU4]deltrophin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor Life Sciences. 55: PL37-PL43. PMID 8015351 DOI: 10.1016/0024-3205(94)90110-4 |
0.415 |
|
| 1994 |
Wild KD, Porreca F, Yamamura HI, Raffa RB. Differentiation of receptor subtypes by thermodynamic analysis: application to opioid delta receptors. Proceedings of the National Academy of Sciences of the United States of America. 91: 12018-21. PMID 7991576 DOI: 10.1073/pnas.91.25.12018 |
0.601 |
|
| 1994 |
Meyer JP, Collins N, Lung FD, Davis P, Zalewska T, Porreca F, Yamamura HI, Hruby VJ. Design, synthesis, and biological properties of highly potent cyclic dynorphin A analogues. Analogues cyclized between positions 5 and 11. Journal of Medicinal Chemistry. 37: 3910-7. PMID 7966152 DOI: 10.1021/Jm00049A010 |
0.513 |
|
| 1994 |
Craft RM, Porreca F. Tetracaine attenuates irritancy without attenuating desensitization produced by intravesical resiniferatoxin in the rat. Pain. 57: 351-9. PMID 7936713 DOI: 10.1016/0304-3959(94)90011-6 |
0.378 |
|
| 1994 |
Connelly CD, Martinez RP, Schupsky JJ, Porreca F, Raffa RB. Etonitazene-induced antinociception in μ1 opioid receptor deficient CXBK mice: Evidence for a role for μ2 receptors in supraspinal antinociception Life Sciences. 54. PMID 7910928 DOI: 10.1016/0024-3205(94)90037-X |
0.449 |
|
| 1994 |
Ossipov MH, Kovelowski CJ, Vanderah T, Porreca F. Naltrindole, an opioid δ antagonist, blocks the enhancement of morphine-antinociception induced by a CCKB antagonist in the rat Neuroscience Letters. 181: 9-12. PMID 7898778 DOI: 10.1016/0304-3940(94)90548-7 |
0.659 |
|
| 1994 |
Lai J, Rothman RB, Lentes KU, Ma SW, Doble A, Zhu RH, Porreca F. Pharmacological characterization of the cloned kappa opioid receptor as a kappa<inf>1b</inf> subtype Neuroreport. 5: 2161-2164. PMID 7865767 DOI: 10.1097/00001756-199410270-00043 |
0.322 |
|
| 1994 |
Misicka A, Lipkowski AW, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Delta opioid receptor selective ligands; DPLPE-deltorphin chimeric peptide analogues. International Journal of Peptide and Protein Research. 44: 80-4. PMID 7718035 DOI: 10.1111/J.1399-3011.1994.Tb00407.X |
0.563 |
|
| 1994 |
Vanderah TW, Lai J, Yamamura HI, Porreca F. Antisense oligodeoxynucleotide to the CCKB receptor produces naltrindole- and [Leu5]enkephalin antiserum-sensitive enhancement of morphine antinociception. Neuroreport. 5: 2601-5. PMID 7696612 DOI: 10.1097/00001756-199412000-00049 |
0.721 |
|
| 1994 |
Wang Z, Bilsky EJ, Porreca F, Sadee W. Constitutive μ opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence Life Sciences. 54. PMID 7514710 DOI: 10.1016/0024-3205(94)90022-1 |
0.469 |
|
| 1994 |
Rao RK, Levenson S, Fang SN, Hruby VJ, Yamamura HI, Porreca F. Role of substance P in the regulation of ion transport by CCKA and CCKB receptors in mouse ileum. Annals of the New York Academy of Sciences. 713: 420-1. PMID 7514373 DOI: 10.1111/J.1749-6632.1994.Tb44113.X |
0.455 |
|
| 1994 |
Ni Q, Xu H, Partilla J, Porreca F, Calderon S, Rice K, Smith L, McNutt R, Rothman R. [3H]SNC121: A novel high affinity ligand for rat brain delta receptors: Preliminary studies Regulatory Peptides. 54: 209-210. DOI: 10.1016/0167-0115(94)90464-2 |
0.366 |
|
| 1994 |
Mayfield KP, Lai J, Porreca F. Selective upregulation of opioid delta receptors in NG 108-15 cells by treatment with cobalt: Possible hypoxic regulation Regulatory Peptides. 54: 183-184. DOI: 10.1016/0167-0115(94)90451-0 |
0.422 |
|
| 1994 |
Lai J, Bilsky EJ, Bernstein RN, Rothman RB, Pasternak GW, Porreca F. Antisense oligodeoxynucleotide to the cloned delta opioid receptor selectively inhibits supraspinal, but not spinal, antinociceptive effects of [D-Ala2, Glu4]deltorphin Regulatory Peptides. 54: 159-160. DOI: 10.1016/0167-0115(94)90439-1 |
0.462 |
|
| 1994 |
Hruby VJ, Collins N, Lung FD, Meyer JP, Davis TP, Yamamura HI, Porreca F. Design of peptides and peptidomimetics for delta and kappa opioid receptor subtypes Regulatory Peptides. 54: 123-124. DOI: 10.1016/0167-0115(94)90420-0 |
0.568 |
|
| 1994 |
Cha XY, Xu H, Calderon SN, Smith LE, Rice KC, Porreca F, Rothman RB. BW373U86, its enantiomers, and related compounds: Interactions of non-peptide delta agonists at multiple δcx binding sites in rat brain Regulatory Peptides. 54: 45-46. DOI: 10.1016/0167-0115(94)90381-6 |
0.317 |
|
| 1994 |
Bilsky EJ, Bernstein RN, Davis P, Calderon SN, Rice KC, Rothman RB, Porreca F. Characterization of enantiomers of (±)BW373U86 and related compounds: Highly selective non-peptidic delta opioid agonists Regulatory Peptides. 54: 25-26. DOI: 10.1016/0167-0115(94)90371-9 |
0.374 |
|
| 1994 |
Misicka A, Lipkowski AW, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Topographic model of delta opioid selective ligands; DPLPE-deltorphin hybrid analogues Regulatory Peptides. 53: S129-S130. DOI: 10.1016/0167-0115(94)90275-5 |
0.57 |
|
| 1994 |
Hruby VJ, Misicka A, Lipkowski AW, Haaseth R, Bartosz H, Qian X, Collins N, Meyer JP, Szabo L, Polt R, Porreca F, Davis T, Yamamura HI. New opioid compounds in analgesia Regulatory Peptides. 53: S71-S72. DOI: 10.1016/0167-0115(94)90246-1 |
0.605 |
|
| 1994 |
Wang Z, Bilsky EJ, Porreca F, Sadée W. Accelerated communciation: Constitutive μ opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence Life Sciences. 54. DOI: 10.1016/0024-3205(94)90022-1 |
0.363 |
|
| 1993 |
Raffa RB, Wild KD, Mosberg HI, Porreca F. Thermodynamic parameters for [D-Pen2,5]enkephalin at δ-opioid receptors in the mouse isolated vas deferens European Journal of Pharmacology: Molecular Pharmacology. 244: 231-238. PMID 8384567 DOI: 10.1016/0922-4106(93)90148-3 |
0.379 |
|
| 1993 |
Reid LD, Hubbell CL, Glaccum MB, Bilsky EJ, Portoghese PS, Porreca F. Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation Life Sciences. 52: PL67-PL71. PMID 8382329 DOI: 10.1016/0024-3205(93)90084-G |
0.35 |
|
| 1993 |
Mosberg HI, Porreca F. A model for the structural basis of delta 2-opioid receptor selectivity Nida Research Monograph. 134: 268-280. PMID 8289883 |
0.309 |
|
| 1993 |
Wild KD, Fang L, McNutt RW, Chang KJ, Toth G, Borsodi A, Yamamura HI, Porreca F. Binding of BW 373U86, a non-peptidic delta opioid receptor agonist, is not regulated by guanine nucleotides and sodium. European Journal of Pharmacology. 246: 289-92. PMID 8223952 DOI: 10.1016/0922-4106(93)90044-A |
0.564 |
|
| 1993 |
Horan PJ, Porreca F. Lack of cross-tolerance between U69,593 and bremazocine suggest κ-opioid receptor multiplicity in mice European Journal of Pharmacology. 239: 93-98. PMID 8223918 DOI: 10.1016/0014-2999(93)90980-V |
0.38 |
|
| 1993 |
Kawasaki AM, Knapp RJ, Kramer TH, Walton A, Wire WS, Hashimoto S, Yamamura HI, Porreca F, Burks TF, Hruby VJ. Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs. Journal of Medicinal Chemistry. 36: 750-7. PMID 8096246 DOI: 10.1021/Jm00058A012 |
0.593 |
|
| 1993 |
Kawasaki AM, Knapp RJ, Walton A, Wire WS, Zalewska T, Yamamura HI, Porreca F, Burks TF, Hruby VJ. Syntheses, opioid binding affinities, and potencies of dynorphin A analogues substituted in positions, 1, 6, 7, 8 and 10. International Journal of Peptide and Protein Research. 42: 411-9. PMID 7906258 DOI: 10.1111/J.1399-3011.1993.Tb00148.X |
0.544 |
|
| 1993 |
Craft RM, Carlisi VJ, Mattia A, Herman RM, Porreca F. Behavioral characterization of the excitatory and desensitizing effects of intravesical capsaicin and resiniferatoxin in the rat. Pain. 55: 205-15. PMID 7508591 DOI: 10.1016/0304-3959(93)90149-J |
0.32 |
|
| 1993 |
Hristova-Kazmierski MK, Horan P, Davis P, Yamamura HI, Kramer T, Horvath R, Kazmierski WM, Porreca F, Hruby VJ. A new approach to enhance bioavailability of biologically active peptides: conjugation of a δ opioid agonist to β-cyclodextrin Bioorganic and Medicinal Chemistry Letters. 3: 831-834. DOI: 10.1016/S0960-894X(00)80675-7 |
0.555 |
|
| 1993 |
Porreca F, Burks TF. Supraspinal Opioid Receptors in Antinociception Handbook of Experimental Pharmacology. 104: 21-51. DOI: 10.1007/978-3-642-77540-6_2 |
0.448 |
|
| 1993 |
Rothman RB, Holaday JW, Porreca F. Allosteric Coupling Among Opioid Receptors: Evidence for an Opioid Receptor Complex Handbook of Experimental Pharmacology. 104: 217-237. DOI: 10.1007/978-3-642-77460-7_10 |
0.342 |
|
| 1993 |
Mattia A, Vanderah T, Raffa RB, Vaught JL, Tallarida RJ, Porreca F. Characterization of the unusual antinociceptive profile of tramadol in mice Drug Development Research. 28: 176-182. DOI: 10.1002/ddr.430280208 |
0.625 |
|
| 1992 |
Menkens K, Bilsky EJ, Wild KD, Portoghese PS, Reid LD, Porreca F. Cocaine place preference is blocked by the δ-opioid receptor antagonist, naltrindole European Journal of Pharmacology. 219: 345-346. PMID 1425962 DOI: 10.1016/0014-2999(92)90319-Y |
0.348 |
|
| 1992 |
Raffa RB, Martinez RP, Porreca F. Lack of antinociceptive efficacy of intracerebroventricular [D-Ala2,Glu4]deltorphin, but not [D-Pen2,D-Pen5]enkephalin, in the μ-opioid receptor deficient CXBX mouse European Journal of Pharmacology. 216: 453-456. PMID 1330585 DOI: 10.1016/0014-2999(92)90446-B |
0.364 |
|
| 1992 |
Horan P, Tallarida RJ, Haaseth RC, Matsunaga TO, Hruby VJ, Porreca F. Antinociceptive interactions of opioid delta receptor agonists with morphine in mice: supra- and sub-additivity. Life Sciences. 50: 1535-41. PMID 1315897 DOI: 10.1016/0024-3205(92)90144-E |
0.438 |
|
| 1992 |
Yamamura MS, Horvath R, Toth G, Otvos F, Malatynska E, Knapp RJ, Porreca F, Hruby VJ, Yamamura HI. Characterization of [3H]naltrindole binding to delta opioid receptors in rat brain. Life Sciences. 50: PL119-24. PMID 1313133 DOI: 10.1016/0024-3205(92)90464-Z |
0.558 |
|
| 1992 |
Tourwé D, Verschueren K, Van Binst G, Davis P, Porreca F, Hruby V. Dermorphin sequence with high δ-afinity by fixing the phe sidechain to trans at ξ1 Bioorganic & Medicinal Chemistry Letters. 2: 1305-1308. DOI: 10.1016/S0960-894X(00)80235-8 |
0.333 |
|
| 1991 |
Rapaka RS, Porreca F. Development of delta opioid peptides as nonaddicting analgesics. Pharmaceutical Research. 8: 1-8. PMID 1849640 DOI: 10.1023/A:1015809702296 |
0.443 |
|
| 1991 |
Rothman RB, Bykov V, Mahboubi A, Long JB, Jiang Q, Porreca F, de Costa BR, Jacobson AE, Rice KC, Holaday JW. Interaction of beta-funaltrexamine with [3H]cycloFOXY binding in rat brain: further evidence that beta-FNA alkylates the opioid receptor complex. Synapse (New York, N.Y.). 8: 86-99. PMID 1652797 DOI: 10.1002/Syn.890080203 |
0.379 |
|
| 1991 |
Mattia A, Vanderah T, Mosberg HI, Omnaas JR, Bowen WD, Porreca F. Pharmacological characterization of [D-Ala2,Leu5,Ser6]enkephalin (DALES): antinociceptive actions at the δnon-complexed-opioid receptor European Journal of Pharmacology. 192: 371-375. PMID 1647317 DOI: 10.1016/0014-2999(91)90227-H |
0.648 |
|
| 1991 |
Wild KD, Vanderah T, Mosberg HI, Porreca F. Opioid δ receptor subtypes are associated with different potassium channels European Journal of Pharmacology. 193: 135-136. PMID 1646729 DOI: 10.1016/0014-2999(91)90215-C |
0.547 |
|
| 1990 |
Porreca F, Qi Jiang, Tallarida RJ. Modulation of morphine antinociception by peripheral [Leu5]enkephalin: a synergistic interaction European Journal of Pharmacology. 179: 463-468. PMID 2364995 DOI: 10.1016/0014-2999(90)90190-H |
0.417 |
|
| 1990 |
Sheldon RJ, Qi JA, Porreca F, Fisher LA. Gastrointestinal motor effects of corticotropin-releasing factor in mice. Regulatory Peptides. 28: 137-51. PMID 2343161 DOI: 10.1016/0167-0115(90)90013-M |
0.306 |
|
| 1990 |
Qi J, Mosberg HI, Porreca F. Selective modulation of morphine antinociception, but not development of tolerance, by δ receptor agonists European Journal of Pharmacology. 186: 137-141. PMID 2178093 DOI: 10.1016/0014-2999(90)94071-5 |
0.452 |
|
| 1990 |
Porreca F, LoPresti D, Ward SJ. Opioid agonist affinity in the guinea-pig ileum and mouse vas deferens. European Journal of Pharmacology. 179: 129-39. PMID 2163849 DOI: 10.1016/0014-2999(90)90410-8 |
0.414 |
|
| 1990 |
Porreca F, Mosberg H, Jiang Q. Modulation of μ-opioid potency and efficacy by opioid δ-agonists without increasing the rate of development of tolerance and degree of physical dependence Pain. 41: S196. DOI: 10.1016/0304-3959(90)92528-X |
0.3 |
|
| 1989 |
Porreca F, Burks TF, Sheldon RJ. Central and peripheral visceral effects of bombesin Annals of the New York Academy of Sciences. 547: 194-203. PMID 3239887 DOI: 10.1111/j.1749-6632.1988.tb23887.x |
0.32 |
|
| 1989 |
Raffa RB, Vaught JL, Porreca F. Can equal pA2 values be compatible with receptor differences? Trends in Pharmacological Sciences. 10: 183-185. PMID 2667226 DOI: 10.1016/0165-6147(89)90234-4 |
0.368 |
|
| 1989 |
Davis TP, Gillespie TJ, Porreca F. Peptide fragments derived from the beta-chain of hemoglobin (hemorphins) are centrally active in vivo. Peptides. 10: 747-51. PMID 2587417 DOI: 10.1016/0196-9781(89)90107-1 |
0.351 |
|
| 1989 |
Heyman JS, Jiang Q, Rothman RB, Mosberg HI, Porreca F. Modulation of μ-mediated antinociception by δ agonists: characterization with antagonists European Journal of Pharmacology. 169: 43-52. PMID 2557223 DOI: 10.1016/0014-2999(89)90815-7 |
0.448 |
|
| 1989 |
Heyman JS, Vaught JL, Mosberg HI, Haaseth RC, Porreca F. Modulation of μ-mediated antinociception by δ agonists in the mouse: selective potentiation of morphine and normorphine by [D-Pen2, D-Pen5]enkephalin European Journal of Pharmacology. 165: 1-10. PMID 2548877 DOI: 10.1016/0014-2999(89)90764-4 |
0.444 |
|
| 1989 |
Raffa RB, Porreca F. Thermodynamic analysis of the drug-receptor interaction Life Sciences. 44: 245-258. PMID 2536880 DOI: 10.1016/0024-3205(89)90182-3 |
0.3 |
|
| 1988 |
Murray CW, Porreca F, Cowan A. Methodological refinements to the mouse paw formalin test. An animal model of tonic pain. Journal of Pharmacological Methods. 20: 175-86. PMID 3221681 DOI: 10.1016/0160-5402(88)90078-2 |
0.428 |
|
| 1988 |
Heyman JS, Vaught JL, Raffa RB, Porreca F. Can supraspinal delta-opioid receptors mediate antinociception? Trends in Pharmacological Sciences. 9: 134-8. PMID 2854316 DOI: 10.1016/0165-6147(88)90195-2 |
0.493 |
|
| 1988 |
Burks TF, Fox DA, Hirning LD, Shook JE, Porreca F. Regulation of gastrointestinal function by multiple opioid receptors. Life Sciences. 43: 2177-81. PMID 2850428 DOI: 10.1016/0024-3205(88)90410-9 |
0.423 |
|
| 1988 |
Jiang Q, Sheldon RJ, Porreca F. Sites of clonidine action to inhibit gut propulsion in mice: Demonstration of a central component Gastroenterology. 95: 1265-1271. PMID 2844620 DOI: 10.1016/0016-5085(88)90360-5 |
0.312 |
|
| 1988 |
Sheldon RJ, Nunan L, Porreca F. U50,488H differentially antagonizes the bladder effects of μ agonists at spinal sites European Journal of Pharmacology. 146: 229-235. PMID 2836207 DOI: 10.1016/0014-2999(88)90297-X |
0.426 |
|
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