Brent E. Korba - Publications

Affiliations: 
Microbiology & Immunology Georgetown University, Washington, DC 
Area:
Virology Biology, Microbiology Biology

106 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Tan S, Groaz E, Kalkeri R, Ptak R, Korba BE, Herdewijn P. Reshaping an Acyclic Nucleoside Phosphonate into a Selective Anti-hepatitis B Virus Compound. Journal of Medicinal Chemistry. 65: 9396-9417. PMID 35754374 DOI: 10.1021/acs.jmedchem.2c00667  0.448
2019 Akkina R, Barber DL, Bility MT, Bissig KD, Burwitz BJ, Eichelberg K, Endsley JJ, Garcia JV, Hafner R, Karakousis PC, Korba BE, Koshy R, Lambros C, Menne S, Nuermberger EL, et al. Small Animal Models for Human Immunodeficiency Virus (HIV), Hepatitis B, and Tuberculosis: Proceedings of an NIAID Workshop. Current Hiv Research. PMID 31870268 DOI: 10.2174/1570162X18666191223114019  0.333
2017 Jones M, Cunningham ME, Wing P, DeSilva S, Challa R, Sheri A, Padmanabhan S, Iyer RP, Korba BE, Afdhal N, Foster GR. SB 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants. Journal of Medical Virology. PMID 28303593 DOI: 10.1002/Jmv.24809  0.51
2015 Mohlman MK, Saleh DA, Ezzat S, Abdel-Hamid M, Korba B, Shetty K, Amr S, Loffredo CA. Viral transmission risk factors in an Egyptian population with high hepatitis C prevalence. Bmc Public Health. 15: 1030. PMID 26446713 DOI: 10.1186/S12889-015-2369-Y  0.418
2015 Korba B, Shetty K, Medvedev A, Viswanathan P, Varghese R, Zhou B, Roy R, Makambi K, Ressom H, Loffredo C. Hepatitis C Virus Genotype 1a Core Gene Nucleotide Patterns Associated with Hepatocellular Carcinoma Risk. The Journal of General Virology. PMID 26296571 DOI: 10.1099/Jgv.0.000219  0.402
2015 de Castro S, Fernández-Cureses G, Andrei G, Snoeck R, Sánchez-Murcia PA, Korba B, Gago F, Balzarini J, Camarasa MJ. Conservation of antiviral activity and improved selectivity in PMEO-DAPym upon pyrimidine to triazine scaffold hopping. Antiviral Research. 122: 64-8. PMID 26275802 DOI: 10.1016/J.Antiviral.2015.08.006  0.412
2014 Kaufman SS, Green KY, Korba BE. Treatment of norovirus infections: moving antivirals from the bench to the bedside. Antiviral Research. 105: 80-91. PMID 24583027 DOI: 10.1016/J.Antiviral.2014.02.012  0.32
2013 Viswanathan P, May J, Uhm S, Yon C, Korba B. RNA binding by human Norovirus 3C-like proteases inhibits protease activity. Virology. 438: 20-7. PMID 23399036 DOI: 10.1016/J.Virol.2013.01.006  0.32
2013 Rawal RK, Singh US, Chavre SN, Wang J, Sugiyama M, Hung W, Govindarajan R, Korba B, Tanaka Y, Chu CK. 2'-Fluoro-6'-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: in vitro anti-HBV activity against the lamivudine-entecavir resistant triple mutant and its mechanism of action. Bioorganic & Medicinal Chemistry Letters. 23: 503-6. PMID 23237841 DOI: 10.1016/J.Bmcl.2012.11.027  0.392
2012 Wang J, Singh US, Rawal RK, Sugiyama M, Yoo J, Jha AK, Scroggin M, Huang Z, Murray MG, Govindarajan R, Tanaka Y, Korba B, Chu CK. Corrigendum to “Antiviral activity of novel 2′-fluoro-6′-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants” [Bioorg. Med. Chem. Lett. 21 (2011) 6328–6331] Bioorganic & Medicinal Chemistry Letters. 22: 2641. DOI: 10.1016/J.Bmcl.2011.10.046  0.413
2011 Stachulski AV, Pidathala C, Row EC, Sharma R, Berry NG, Lawrenson AS, Moores SL, Iqbal M, Bentley J, Allman SA, Edwards G, Helm A, Hellier J, Korba BE, Semple JE, et al. Thiazolides as novel antiviral agents. 2. Inhibition of hepatitis C virus replication. Journal of Medicinal Chemistry. 54: 8670-80. PMID 22059983 DOI: 10.1021/jm201264t  0.457
2011 Wang J, Singh US, Rawal RK, Sugiyama M, Sugiyama M, Yoo J, Jha AK, Scroggin M, Huang Z, Murray MG, Govindarajan R, Tanaka Y, Korba B, Chu CK. Antiviral activity of novel 2'-fluoro-6'-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants. Bioorganic & Medicinal Chemistry Letters. 21: 6328-31. PMID 21930377 DOI: 10.1016/J.Bmcl.2011.08.113  0.413
2011 Yon C, Viswanathan P, Rossignol JF, Korba B. Mutations in HCV non-structural genes do not contribute to resistance to nitazoxanide in replicon-containing cells. Antiviral Research. 91: 233-40. PMID 21703309 DOI: 10.1016/J.Antiviral.2011.05.017  0.431
2011 Gadthula S, Rawal RK, Sharon A, Wu D, Korba B, Chu CK. Synthesis and antiviral activity of cyclopropyl-spirocarbocyclic adenosine, (4R,5S,6R,7R)-4-(6-amino-9H-purin-9-yl)-7-(hydroxymethyl)spiro[2.4]heptane-5,6-diol against hepatitis C virus Bioorganic & Medicinal Chemistry Letters. 21: 3982-3985. PMID 21621997 DOI: 10.1016/J.Bmcl.2011.05.012  0.431
2011 Stachulski AV, Pidathala C, Row EC, Sharma R, Berry NG, Iqbal M, Bentley J, Allman SA, Edwards G, Helm A, Hellier J, Korba BE, Semple JE, Rossignol JF. Thiazolides as novel antiviral agents. 1. Inhibition of hepatitis B virus replication. Journal of Medicinal Chemistry. 54: 4119-32. PMID 21553812 DOI: 10.1021/Jm200153P  0.514
2011 Montero A, Viswanathan P, Yon C, Korba B. Nitazoxanide is an Indirect Inhibitor of HCV Replication Through Modulation of Cellular Kinase CKI Alpha to Enhance HCV NS5A Hyperphosphorylation Antiviral Research. 90. DOI: 10.1016/J.Antiviral.2011.03.115  0.6
2010 Wauchope OR, Tomney MJ, Pepper JL, Korba BE, Seley-Radtke KL. Tricyclic 2'-C-modified nucleosides as potential anti-HCV therapeutics. Organic Letters. 12: 4466-9. PMID 20845910 DOI: 10.1021/Ol101482H  0.464
2010 Niu C, Bao H, Tolstykh T, Micolochick Steuer HM, Murakami E, Korba B, Furman PA. Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/nucleotide inhibitors. Antiviral Therapy. 15: 401-12. PMID 20516559 DOI: 10.3851/Imp1541  0.442
2010 Bader T, Korba B. Simvastatin potentiates the anti-hepatitis B virus activity of FDA-approved nucleoside analogue inhibitors in vitro. Antiviral Research. 86: 241-245. PMID 20211652 DOI: 10.1016/J.Antiviral.2010.02.325  0.485
2010 Coughlin JE, Padmanabhan S, Zhang G, Kirk CJ, Govardhan CP, Korba BE, O'Loughlin K, Green CE, Mirsalis J, Morrey JD, Iyer RP. Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs. Bioorganic & Medicinal Chemistry Letters. 20: 1783-6. PMID 20117930 DOI: 10.1016/J.Antiviral.2010.02.378  0.516
2010 Brnakova Z, Chandler KB, Bekesova S, Lenco J, Bebu I, Kosti O, Shetty K, Korba BE, Ressom HW, Varghese RS, Novotny MV, Goldman R. Abstract 5569: N-glycosylation in cultured cells and hepatocellular carcinoma Cancer Research. 70: 5569-5569. DOI: 10.1158/1538-7445.Am10-5569  0.403
2010 Tomney M, Korba B, Zimmermann S, Seley-Radtke K. Synthesis of a Series of 2′-Modified Tricyclic Nucleosides as Potential HCV Agents Antiviral Research. 86: A68. DOI: 10.1016/J.Antiviral.2010.02.472  0.402
2009 Morrey JD, Korba BE, Beadle JR, Wyles DL, Hostetler KY. Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo. Antimicrobial Agents and Chemotherapy. 53: 2865-70. PMID 19398648 DOI: 10.1128/Aac.00114-09  0.518
2009 Wyles DL, Kaihara KA, Korba BE, Schooley RT, Beadle JR, Hostetler KY. The octadecyloxyethyl ester of (S)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]adenine is a potent and selective inhibitor of hepatitis C virus replication in genotype 1A, 1B, and 2A replicons. Antimicrobial Agents and Chemotherapy. 53: 2660-2. PMID 19289518 DOI: 10.1128/Aac.01546-08  0.388
2009 Kim HJ, Sharon A, Bal C, Wang J, Allu M, Huang Z, Murray MG, Bassit L, Schinazi RF, Korba B, Chu CK. Synthesis and anti-hepatitis B virus and anti-hepatitis C virus activities of 7-deazaneplanocin A analogues in vitro. Journal of Medicinal Chemistry. 52: 206-13. PMID 19072694 DOI: 10.1021/Jm801418V  0.533
2009 Korba B, Glenn J, Elazar M, Rossignol J. A Role for Nitazoxanide in Combination with STAT-C Agents for Inhibition of HCV Replication and the Potential for the Prevention of Viral Resistance Antiviral Research. 82. DOI: 10.1016/J.Antiviral.2009.02.022  0.451
2008 Korba BE, Elazar M, Lui P, Rossignol JF, Glenn JS. Potential for hepatitis C virus resistance to nitazoxanide or tizoxanide. Antimicrobial Agents and Chemotherapy. 52: 4069-71. PMID 18710916 DOI: 10.1128/Aac.00078-08  0.479
2008 Bourne C, Lee S, Venkataiah B, Lee A, Korba B, Finn MG, Zlotnick A. Small-molecule effectors of hepatitis B virus capsid assembly give insight into virus life cycle. Journal of Virology. 82: 10262-70. PMID 18684823 DOI: 10.1128/Jvi.01360-08  0.453
2008 Li C, Prichard MN, Korba BE, Drach JC, Zemlicka J. Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine. Bioorganic & Medicinal Chemistry. 16: 2148-55. PMID 18082410 DOI: 10.1016/J.Bmc.2007.11.082  0.328
2008 Korba BE, Montero AB, Farrar K, Gaye K, Mukerjee S, Ayers MS, Rossignol JF. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Research. 77: 56-63. PMID 17888524 DOI: 10.1016/J.Antiviral.2007.08.005  0.721
2008 Werman A, Korba BE, Alkahe B, Finkelshtein D, Bujanover S, Novick D, Vinocour E, Rubinstein M. 54 A soluble form of the LDL receptor inhibits hepatitis B virus replication in vitro Cytokine. 43: 249-249. DOI: 10.1016/J.Cyto.2008.07.095  0.499
2008 Johnston B, Vlassov A, Korba B, Farrar K, Mukerjee S, Seyhan A, ILves H, Kaspar R, Leake D, Kazakov S, Ge Q. Optimization of shRNA Features for Targeting Hepatitis C Virus Antiviral Research. 78: A41. DOI: 10.1016/J.Antiviral.2008.01.078  0.434
2007 Painter GR, Almond MR, Trost LC, Lampert BM, Neyts J, De Clercq E, Korba BE, Aldern KA, Beadle JR, Hostetler KY. Evaluation of hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)propyl]- adenine, CMX157, as a potential treatment for human immunodeficiency virus type 1 and hepatitis B virus infections. Antimicrobial Agents and Chemotherapy. 51: 3505-9. PMID 17646420 DOI: 10.1128/Aac.01375-07  0.448
2007 Vlassov AV, Korba B, Farrar K, Mukerjee S, Seyhan AA, Ilves H, Kaspar RL, Leake D, Kazakov SA, Johnston BH. shRNAs targeting hepatitis C: effects of sequence and structural features, and comparision with siRNA. Oligonucleotides. 17: 223-36. PMID 17638526 DOI: 10.1089/Oli.2006.0069  0.441
2007 Zhang P, Zhang N, Korba BE, Hosmane RS. Structure-activity relationship studies on anti-HCV activity of ring-expanded ('fat') nucleobase analogues containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system. Bioorganic & Medicinal Chemistry Letters. 17: 2225-8. PMID 17300935 DOI: 10.1016/J.Bmcl.2007.01.085  0.383
2007 Izzo F, Montella M, Orlando AP, Nasti G, Beneduce G, Castello G, Cremona F, Ensor CM, Holtzberg FW, Bomalaski JS, Clark MA, Curley SA, Orlando R, Scordino F, Korba BE. Pegylated arginine deiminase lowers hepatitis C viral titers and inhibits nitric oxide synthesis. Journal of Gastroenterology and Hepatology. 22: 86-91. PMID 17201887 DOI: 10.1111/J.1440-1746.2006.04463.X  0.484
2007 Choo H, Beadle JR, Kern ER, Prichard MN, Keith KA, Hartline CB, Trahan J, Aldern KA, Korba BE, Hostetler KY. Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters. Antimicrobial Agents and Chemotherapy. 51: 611-5. PMID 17130297 DOI: 10.1128/Aac.00444-06  0.545
2007 Kim H, Sharon A, Korba BE, Chu CK. Synthesis and Anti-HBV Activity of 7-Deaza-Neplanocin A Analogs Antiviral Research. 74. DOI: 10.1016/J.Antiviral.2007.01.088  0.435
2007 Johnston B, Vlassov A, Korba B, Ilves H, Kaspar R, Kazakov S, Farrar K, Mukerjee S, Seyhan A. shRNAs Targeting Hepatitis C: Effects of Sequence and Structural Features, and Comparison with siRNA Antiviral Research. 74. DOI: 10.1016/J.Antiviral.2007.01.087  0.339
2007 IYER R, PADMANABHAN S, COUGHLIN J, ZHANG G, KIRK C, KORBA B, MORREY J. Initial Pharmacodynamic Evaluation of Orally Bioavailable Prodrugs of SB-9000, a Novel Anti-HBV Agent Antiviral Research. 74: A54-A55. DOI: 10.1016/J.Antiviral.2007.01.074  0.385
2007 Korba B, Abigail M, Marc A, Rossignol J. Nitazoxanide is an Effective Antiviral Agent Against Both HBV and HCV replication in vitro Antiviral Research. 74. DOI: 10.1016/J.Antiviral.2007.01.039  0.509
2006 Korba BE, Furman PA, Otto MJ. Clevudine: a potent inhibitor of hepatitis B virus in vitro and in vivo. Expert Review of Anti-Infective Therapy. 4: 549-61. PMID 17009935 DOI: 10.1586/14787210.4.4.549  0.525
2005 Zhang P, Zhang N, Korba BE, Hosmane RS. Synthesis and in vitro anti-hepatitis B and C virus activities of ring-expanded ('fat') nucleobase analogues containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system. Bioorganic & Medicinal Chemistry Letters. 15: 5397-401. PMID 16213713 DOI: 10.1016/J.Bmcl.2005.09.015  0.488
2005 Casey J, Cote PJ, Toshkov IA, Chu CK, Gerin JL, Hornbuckle WE, Tennant BC, Korba BE. Clevudine inhibits hepatitis delta virus viremia: a pilot study of chronically infected woodchucks. Antimicrobial Agents and Chemotherapy. 49: 4396-9. PMID 16189132 DOI: 10.1128/Aac.49.10.4396-4399.2005  0.565
2005 Iyer RP, Padmanabhan S, Zhang G, Morrey JD, Korba BE. Nucleotide analogs as novel anti-hepatitis B virus agents. Current Opinion in Pharmacology. 5: 520-8. PMID 16087397 DOI: 10.1016/J.Coph.2005.04.019  0.54
2005 Yang M, Schneller SW, Korba B. 5'-Homoneplanocin A inhibits hepatitis B and hepatitis C. Journal of Medicinal Chemistry. 48: 5043-6. PMID 16033283 DOI: 10.1021/Jm058200E  0.506
2005 Menne S, Cote PJ, Korba BE, Butler SD, George AL, Tochkov IA, Delaney WE, Xiong S, Gerin JL, Tennant BC. Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrobial Agents and Chemotherapy. 49: 2720-8. PMID 15980342 DOI: 10.1128/Aac.49.7.2720-2728.2005  0.544
2005 Okuse C, Rinaudo JA, Farrar K, Wells F, Korba BE. Enhancement of antiviral activity against hepatitis C virus in vitro by interferon combination therapy. Antiviral Research. 65: 23-34. PMID 15652968 DOI: 10.1016/J.Antiviral.2004.09.002  0.424
2004 Jacob JR, Korba BE, You JE, Tennant BC, Kim YH. Korean medicinal plant extracts exhibit antiviral potency against viral hepatitis. Journal of Alternative and Complementary Medicine (New York, N.Y.). 10: 1019-26. PMID 15673997 DOI: 10.1089/Acm.2004.10.1019  0.596
2004 Korba BE, Cote PJ, Menne S, Toshkov I, Baldwin BH, Wells FV, Tennant BC, Gerin JL. Clevudine therapy with vaccine inhibits progression of chronic hepatitis and delays onset of hepatocellular carcinoma in chronic woodchuck hepatitis virus infection. Antiviral Therapy. 9: 937-52. PMID 15651753  0.39
2004 Tennant BC, Toshkov IA, Peek SF, Jacob JR, Menne S, Hornbuckle WE, Schinazi RD, Korba BE, Cote PJ, Gerin JL. Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infection. Gastroenterology. 127: S283-93. PMID 15508096 DOI: 10.1053/J.Gastro.2004.09.043  0.499
2004 Jacob JR, Korba BE, Cote PJ, Toshkov I, Delaney WE, Gerin JL, Tennant BC. Suppression of lamivudine-resistant B-domain mutants by adefovir dipivoxil in the woodchuck hepatitis virus model. Antiviral Research. 63: 115-21. PMID 15302140 DOI: 10.1016/J.Antiviral.2004.03.005  0.444
2004 Iyer RP, Roland A, Jin Y, Mounir S, Korba B, Julander JG, Morrey JD. Anti-hepatitis B virus activity of ORI-9020, a novel phosphorothioate dinucleotide, in a transgenic mouse model. Antimicrobial Agents and Chemotherapy. 48: 2318-20. PMID 15155244 DOI: 10.1128/Aac.48.6.2318-2320.2004  0.514
2004 Iyer RP, Jin Y, Roland A, Morrey JD, Mounir S, Korba B. Phosphorothioate di- and trinucleotides as a novel class of anti-hepatitis B virus agents. Antimicrobial Agents and Chemotherapy. 48: 2199-205. PMID 15155222 DOI: 10.1128/Aac.48.6.2199-2205.2004  0.547
2004 Jacob JR, Sterczer A, Toshkov IA, Yeager AE, Korba BE, Cote PJ, Buendia MA, Gerin JL, Tennant BC. Integration of woodchuck hepatitis and N-myc rearrangement determine size and histologic grade of hepatic tumors. Hepatology (Baltimore, Md.). 39: 1008-16. PMID 15057905 DOI: 10.1002/Hep.20106  0.357
2004 Ciancio A, Smedile A, Rizzetto M, Lagget M, Gerin J, Korba B. Identification of HBV DNA sequences that are predictive of response to lamivudine therapy. Hepatology. 39: 64-73. PMID 14752824 DOI: 10.1002/Hep.20019  0.471
2002 Menne S, Roneker CA, Tennant BC, Korba BE, Gerin JL, Cote PJ. Immunogenic effects of woodchuck hepatitis virus surface antigen vaccine in combination with antiviral therapy: breaking of humoral and cellular immune tolerance in chronic woodchuck hepatitis virus infection. Intervirology. 45: 237-50. PMID 12566706 DOI: 10.1159/000067914  0.445
2002 Hurwitz SJ, Tennant BC, Korba BE, Liberman I, Gerin JL, Schinazi RF. Viral pharmacodynamic model for (-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine (emtricitabine) in chronically infected woodchucks. Antiviral Chemistry & Chemotherapy. 13: 165-76. PMID 12448689 DOI: 10.1177/095632020201300303  0.489
2002 Tatti KM, Korba BE, Stang HL, Peek S, Gerin JL, Tennant BC, Schinazi RF. Mutations in the conserved woodchuck hepatitis virus polymerase FLLA and YMDD regions conferring resistance to lamivudine. Antiviral Research. 55: 141-50. PMID 12076758 DOI: 10.1016/S0166-3542(02)00019-0  0.456
2002 Menne S, Roneker CA, Korba BE, Gerin JL, Tennant BC, Cote PJ. Immunization with surface antigen vaccine alone and after treatment with 1-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)-uracil (L-FMAU) breaks humoral and cell-mediated immune tolerance in chronic woodchuck hepatitis virus infection. Journal of Virology. 76: 5305-14. PMID 11991959 DOI: 10.1128/Jvi.76.11.5305-5314.2002  0.52
2002 Sood RK, Bhadti VS, Fattom AI, Naso RB, Korba BE, Kern ER, Chen HM, Hosmane RS. Novel ring-expanded nucleoside analogs exhibit potent and selective inhibition of hepatitis B virus replication in cultured human hepatoblastoma cells. Antiviral Research. 53: 159-64. PMID 11750942 DOI: 10.1016/S0166-3542(01)00204-2  0.485
2001 Bryant ML, Bridges EG, Placidi L, Faraj A, Loi AG, Pierra C, Dukhan D, Gosselin G, Imbach JL, Hernandez B, Juodawlkis A, Tennant B, Korba B, Cote P, Cretton-Scott E, et al. Anti-HBV specific beta-L-2'-deoxynucleosides. Nucleosides, Nucleotides & Nucleic Acids. 20: 597-607. PMID 11563077 DOI: 10.1081/Ncn-100002336  0.524
2001 Jin Y, Chen X, Côté M, Roland A, Korba B, Mounir S, Iyer RP. Parallel solid-phase synthesis of nucleoside phosphoramidate libraries. Bioorganic & Medicinal Chemistry Letters. 11: 2057-60. PMID 11514138 DOI: 10.1016/S0960-894X(01)00380-8  0.418
2001 Peek SF, Cote PJ, Jacob JR, Toshkov IA, Hornbuckle WE, Baldwin BH, Wells FV, Chu CK, Gerin JL, Tennant BC, Korba BE. Antiviral activity of clevudine [L-FMAU, (1-(2-fluoro-5-methyl-beta, L-arabinofuranosyl) uracil)] against woodchuck hepatitis virus replication and gene expression in chronically infected woodchucks (Marmota monax). Hepatology (Baltimore, Md.). 33: 254-66. PMID 11124844 DOI: 10.1053/Jhep.2001.20899  0.551
2001 Bryant ML, Bridges EG, Placidi L, Faraj A, Loi AG, Pierra C, Dukhan D, Gosselin G, Imbach JL, Hernandez B, Juodawlkis A, Tennant B, Korba B, Cote P, Marion P, et al. Antiviral L-nucleosides specific for hepatitis B virus infection. Antimicrobial Agents and Chemotherapy. 45: 229-35. PMID 11120971 DOI: 10.1128/Aac.45.1.229-235.2001  0.486
2000 Schmidt K, Korba B. Hepatitis B virus cell culture assays for antiviral activity. Methods in Molecular Medicine. 24: 51-67. PMID 21331899 DOI: 10.1385/1-59259-245-7:51  0.543
2000 Cote PJ, Toshkov I, Bellezza C, Ascenzi M, Roneker C, Ann Graham L, Baldwin BH, Gaye K, Nakamura I, Korba BE, Tennant BC, Gerin JL. Temporal pathogenesis of experimental neonatal woodchuck hepatitis virus infection: increased initial viral load and decreased severity of acute hepatitis during the development of chronic viral infection. Hepatology (Baltimore, Md.). 32: 807-17. PMID 11003627 DOI: 10.1053/Jhep.2000.17681  0.474
2000 Hostetler KY, Beadle JR, Hornbuckle WE, Bellezza CA, Tochkov IA, Cote PJ, Gerin JL, Korba BE, Tennant BC. Antiviral activities of oral 1-O-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infection Antimicrobial Agents and Chemotherapy. 44: 1964-1969. PMID 10858362 DOI: 10.1128/Aac.44.7.1964-1969.2000  0.565
2000 Korba BE, Schinazi RF, Cote P, Tennant BC, Gerin JL. Effect of oral administration of emtricitabine on woodchuck hepatitis virus replication in chronically infected woodchucks Antimicrobial Agents and Chemotherapy. 44: 1757-1760. PMID 10817750 DOI: 10.1128/Aac.44.6.1757-1760.2000  0.586
2000 Korba BE, Cote P, Hornbuckle W, Tennant BC, Gerin JL. Treatment of chronic woodchuck hepatitis virus infection in the Eastern woodchuck (Marmota monax) with nucleoside analogues is predictive of therapy for chronic hepatitis B virus infection in humans. Hepatology (Baltimore, Md.). 31: 1165-75. PMID 10796894 DOI: 10.1053/He.2000.5982  0.551
2000 Korba BE, Cote P, Hornbuckle W, Schinazi R, Gerin JL, Tennant BC. Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication in chronic WHV carrier woodchucks Antiviral Research. 45: 19-32. PMID 10774587 DOI: 10.1016/S0166-3542(99)00072-8  0.564
2000 Cote PJ, Korba BE, Miller RH, Jacob JR, Baldwin BH, Hornbuckle WE, Purcell RH, Tennant BC, Gerin JL. Effects of age and viral determinants on chronicity as an outcome of experimental woodchuck hepatitis virus infection. Hepatology (Baltimore, Md.). 31: 190-200. PMID 10613745 DOI: 10.1002/Hep.510310128  0.441
2000 Korba BE, Cote P, Hornbuckle W, Schinazi R, Gerin JL, Tennant BC. Corrigendum to “Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication in chronic WHV carrier woodchucks” Antiviral Research. 45: 155-156. DOI: 10.1016/S0166-3542(00)00078-4  0.379
1999 Morrey JD, Bailey KW, Korba BE, Sidwell RW. Utilization of transgenic mice replicating high levels of hepatitis B virus for antiviral evaluation of lamivudine Antiviral Research. 42: 97-108. PMID 10389653 DOI: 10.1016/S0166-3542(99)00009-1  0.502
1999 Périgaud C, Gosselin G, Girardet JL, Korba BE, Imbach JL. The S-acyl-2-thioethyl pronucleotide approach applied to acyclovir: part I. Synthesis and in vitro anti-hepatitis B virus activity of bis(S-acyl-2-thioethyl)phosphotriester derivatives of acyclovir. Antiviral Research. 40: 167-78. PMID 10027651 DOI: 10.1016/S0166-3542(98)00059-X  0.554
1998 Zembower DE, Lin YM, Flavin MT, Chen FC, Korba BE. Robustaflavone, a potential non-nucleoside anti-hepatitis B agent. Antiviral Research. 39: 81-8. PMID 9806485 DOI: 10.1016/S0166-3542(98)00033-3  0.474
1998 Hurwitz SJ, Tennant BC, Korba BE, Gerin JL, Schinazi RF. Pharmacodynamics of (-)-β-2',3'-dideoxy-3'-thiacytidine in chronically virus-infected woodchucks compared to its pharmacodynamics in humans Antimicrobial Agents and Chemotherapy. 42: 2804-2809. PMID 9797207 DOI: 10.1128/Aac.42.11.2804  0.506
1998 Seley KL, Schneller SW, De Clercq E, Rattendi D, Lane S, Bacchi CJ, Korba B. The importance of the 4'-hydroxyl hydrogen for the anti-trypanosomal and antiviral properties of (+)-5'-noraristeromycin and two 7-deaza analogues Bioorganic and Medicinal Chemistry. 6: 797-801. PMID 9681145 DOI: 10.1016/S0968-0896(98)00036-4  0.316
1998 Tennant BC, Baldwin BH, Graham LA, Ascenzi MA, Hornbuckle WE, Rowland PH, Tochkov IA, Yeager AE, Erb HN, Colacino JM, Lopez C, Engelhardt JA, Bowsher RR, Richardson FC, Lewis W, ... ... Korba BE, et al. Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection. Hepatology (Baltimore, Md.). 28: 179-91. PMID 9657111 DOI: 10.1002/Hep.510280124  0.462
1998 Block TM, Lu X, Mehta AS, Blumberg BS, Tennant B, Ebling M, Korba B, Lansky DM, Jacob GS, Dwek RA. Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking. Nature Medicine. 4: 610-4. PMID 9585237 DOI: 10.1038/Nm0598-610  0.515
1997 Valette G, Girardet J, Pompon A, Périgaud C, Gosselin G, Korba B, Hantz O, Imbach J. The Pronucleotide Approach. III. Synthesis, Anti-HBV Activity and Stability Studies of the Bis(S-pivaloyl-2-thioethyl) Phosphotriester Derivative of Acyclovir Nucleosides, Nucleotides & Nucleic Acids. 16: 1331-1335. DOI: 10.1080/07328319708006182  0.425
1997 Mansour TS, Evans CA, Siddiqui MA, Charron M, Zacharie B, Nguyen-Ba N, Lee N, Korba B. Structure-Activity Relationship of Pyrimidine Heterosubstituted Nucleoside Analogues Nucleosides, Nucleotides & Nucleic Acids. 16: 993-1001. DOI: 10.1080/07328319708006122  0.428
1997 Seley KL, Schneller SW, Korba B. A 5′-noraristeromycin enantiomer with activity towards hepatitis B virus Nucleosides and Nucleotides. 16: 2095-2099. DOI: 10.1080/07328319708002560  0.547
1997 Lin YM, Zembower DE, Flavin MT, Schure RM, Anderson HM, Korba BE, Chen FC. Robustaflavone, a naturally occurring biflavanoid, is a potent non-nucleoside inhibitor of hepatitis B virus replication in vitro Bioorganic and Medicinal Chemistry Letters. 7: 2325-2328. DOI: 10.1016/S0960-894X(97)00422-8  0.504
1997 Mansour TS, Evans CA, Charron M, Korba BE. Discovery of imidazo[1,2-c]pyrimidin-5(6H)-one heterosubstituted nucleoside analogues with potent activity against human hepatitis B virus in vitro Bioorganic and Medicinal Chemistry Letters. 7: 303-308. DOI: 10.1016/S0960-894X(97)00001-2  0.52
1996 Korba BE, Boyd MR. Penciclovir is a selective inhibitor of hepatitis B virus replication in cultured human hepatoblastoma cells Antimicrobial Agents and Chemotherapy. 40: 1282-1284. PMID 8723485 DOI: 10.1128/Aac.40.5.1282  0.542
1996 Korba BE. In vitro evaluation of combination therapies against hepatitis B virus replication Antiviral Research. 29: 49-51. PMID 8721544 DOI: 10.1016/0166-3542(95)00915-9  0.536
1995 Korba BE, Gerin JL. Antisense oligonucleotides are effective inhibitors of hepatitis B virus replication in vitro Antiviral Research. 28: 225-242. PMID 8629815 DOI: 10.1016/0166-3542(95)00050-V  0.538
1994 Hostetler KY, Korba BE, Sridhar CN, Gardner MF. Antiviral activity of phosphatidyl-dideoxycytidine in hepatitis B-infected cells and enhanced hepatic uptake in mice Antiviral Research. 24: 59-67. PMID 7944313 DOI: 10.1016/0166-3542(94)90052-3  0.494
1992 Müller C, Bergmann KF, Gerin JL, Korba BE. Production of Hepatitis B Virus by Stably Transfected Monocytic Cell Line U-937: A Model for Extrahepatic Hepatitis B Virus Replication The Journal of Infectious Diseases. 165: 929-933. PMID 1569345 DOI: 10.1093/Infdis/165.5.929  0.508
1992 Gerin JL, Korba BE, Cote PJ, Tennant BC. A preliminary report of a controlled study of thymosin alpha-1 in the woodchuck model of hepadnavirus infection Advances in Experimental Medicine and Biology. 312: 121-123. PMID 1514437 DOI: 10.1007/978-1-4615-3462-4_11  0.478
1992 Cote PJ, Korba BE, Baldwin B, Hornbuckle WE, Tennant BC, Gerin JL. Immunosuppression with Cyclosporine during the Incubation Period of Experimental Woodchuck Hepatitis Virus Infection Increases the Frequency of Chronic Infection in Adult Woodchucks The Journal of Infectious Diseases. 166: 628-631. PMID 1500746 DOI: 10.1093/Infdis/166.3.628  0.407
1992 Korba BE, Gerin JL. Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication. Antiviral Research. 19: 55-70. PMID 1444322 DOI: 10.1016/0166-3542(92)90056-B  0.507
1991 Korba BE, Milman G. A cell culture assay for compounds which inhibit hepatitis B virus replication. Antiviral Research. 15: 217-228. PMID 1716089 DOI: 10.1016/0166-3542(91)90068-3  0.516
1991 Korba B, Tennant B, Cote P, Gerin J. Treatment of chronic carriers of woodchuck hepatitis virus infection with thymosin alpha-1 Antiviral Research. 15: 131. DOI: 10.1016/0166-3542(91)90250-U  0.481
1991 Tennant BC, Mrosovsky N, McLean K, Cote PJ, Korba BE, Engle RE, Gerin JL, Wright J, Michener GR, Uhl E, King JM. Hepatocellular carcinoma in Richardson's ground squirrels (Spermophilus richardsonii): evidence for association with hepatitis B-like virus infection. Hepatology. 13: 1215-1221. DOI: 10.1002/Hep.1840130630  0.5
1990 Korba BE, Brown TL, Wells FV, Baldwin B, Cote PJ, Steinberg H, Tennant BC, Gerin JL. Natural history of experimental woodchuck hepatitis virus infection: molecular virologic features of the pancreas, kidney, ovary, and testis. Journal of Virology. 64: 4499-4506. PMID 2384922 DOI: 10.1128/Jvi.64.9.4499-4506.1990  0.448
1990 Miller RH, Girones R, Cote PJ, Hornbuckle WE, Chestnut T, Baldwin BH, Korba BE, Tennant BC, Gerin JL, Purcell RH. Evidence against a requisite role for defective virus in the establishment of persistent hepadnavirus infections. Proceedings of the National Academy of Sciences of the United States of America. 87: 9329-32. PMID 2251274 DOI: 10.1073/Pnas.87.23.9329  0.47
1990 Korba BE, Boumpas D, Mann D, Yoakum GH. Direct modulation of HBV surface antigen in a human, HBsAg-producing hepatocellular carcinoma cell line by alpha, beta, or gamma interferons. Journal of Medical Virology. 31: 272-276. PMID 2176672 DOI: 10.1002/Jmv.1890310406  0.428
1989 Negro F, Korba BE, Forzani B, Baroudy BM, Brown TL, Gerin JL, Ponzetto A. Hepatitis delta virus (HDV) and woodchuck hepatitis virus (WHV) nucleic acids in tissues of HDV-infected chronic WHV carrier woodchucks. Journal of Virology. 63: 1612-1618. PMID 2926865 DOI: 10.1128/Jvi.63.4.1612-1618.1989  0.439
1989 Korba BE, Cote PJ, Wells FV, Baldwin B, Popper H, Purcell RH, Tennant BC, Gerin JL. Natural history of woodchuck hepatitis virus infections during the course of experimental viral infection: molecular virologic features of the liver and lymphoid tissues. Journal of Virology. 63: 1360-1370. PMID 2915383 DOI: 10.1128/Jvi.63.3.1360-1370.1989  0.453
1989 Korba BE, Cote PJ, Shapiro M, Purcell RH, Gerin JL. In vitro production of infectious woodchuck hepatitis virus by lipopolysaccharide-stimulated peripheral blood lymphocytes. The Journal of Infectious Diseases. 160: 572-6. PMID 2794556 DOI: 10.1093/Infdis/160.4.572  0.465
1988 Korba BE, Gowans EJ, Wells FV, Tennant BC, Clarke R, Gerin JL. Systemic distribution of woodchuck hepatitis virus in the tissues of experimentally infected woodchucks Virology. 165: 172-181. PMID 3388768 DOI: 10.1016/0042-6822(88)90670-8  0.407
1988 Korba B, Cote P, Gerin J. Mitogen-induced replication of woodchuck hepatitis virus in cultured peripheral blood lymphocytes. Science. 241: 1213-1216. PMID 3261887 DOI: 10.1126/Science.3261887  0.426
1987 Korba BE, Wells F, Tennant BC, Cote PJ, Gerin JL. Lymphoid cells in the spleens of woodchuck hepatitis virus-infected woodchucks are a site of active viral replication Journal of Virology. 61: 1318-1324. PMID 3573141 DOI: 10.1128/Jvi.61.5.1318-1324.1987  0.438
1986 Korba BE, Wells F, Tennant BC, Yoakum GH, Purcell RH, Gerin JL. Hepadnavirus infection of peripheral blood lymphocytes in vivo: woodchuck and chimpanzee models of viral hepatitis. Journal of Virology. 58: 1-8. PMID 3485201 DOI: 10.1128/Jvi.58.1.1-8.1986  0.494
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