Alexander J. Szalai - Publications

Affiliations: 
Microbiology University of Alabama, Birmingham, Birmingham, AL, United States 
Area:
Immunology
Website:
https://www.uab.edu/medicine/rheumatology/faculty/52-alexander-j-szalai-phd

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Avery JT, Jimenez RV, Blake JL, Wright TT, Leόn-Ruiz B, Schoeb TR, Szalai AJ, Bullard DC. Mice expressing the variant rs1143679 allele of ITGAM (CD11b) show impaired DC-mediated T cell proliferation. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 31673770 DOI: 10.1007/s00335-019-09819-y  0.4
2019 Jimenez RV, Kuznetsova V, Connelly AN, Hel Z, Szalai AJ. C-Reactive Protein Promotes the Expansion of Myeloid Derived Cells With Suppressor Functions. Frontiers in Immunology. 10: 2183. PMID 31620123 DOI: 10.3389/fimmu.2019.02183  0.4
2018 Jimenez RV, Wright TT, Jones NR, Wu J, Gibson AW, Szalai AJ. C-Reactive Protein Impairs Dendritic Cell Development, Maturation, and Function: Implications for Peripheral Tolerance. Frontiers in Immunology. 9: 372. PMID 29556231 DOI: 10.3389/fimmu.2018.00372  0.4
2016 Lai W, Tang Y, Huang XR, Ming-Kuen Tang P, Xu A, Szalai AJ, Lou TQ, Lan HY. C-reactive protein promotes acute kidney injury via Smad3-dependent inhibition of CDK2/cyclin E. Kidney International. PMID 27470679 DOI: 10.1016/j.kint.2016.06.010  0.36
2016 Li J, Wei D, McCrory MA, Szalai AJ, Yang G, Li L, Li F, Zhao AZ. Human C-Reactive Protein Impedes Entry of Leptin into the CNS and Attenuates Its Physiological Actions in the CNS. The Biochemical Journal. PMID 26933237 DOI: 10.1042/BJ20151282  0.32
2015 Wright TT, Jimenez RV, Morgan TE, Bali N, Hou X, McCrory MA, Finch CE, Szalai AJ. Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice. Autoimmune Diseases. 2015: 640171. PMID 26421184 DOI: 10.1155/2015/640171  0.32
2015 Zhang L, Liu SH, Wright TT, Shen ZY, Li HY, Zhu W, Potempa LA, Ji SR, Szalai AJ, Wu Y. C-reactive protein directly suppresses Th1 cell differentiation and alleviates experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 194: 5243-52. PMID 25917100 DOI: 10.4049/jimmunol.1402909  0.32
2014 Mrug M, Zhou J, Mrug S, Guay-Woodford LM, Yoder BK, Szalai AJ. Complement C3 activation in cyst fluid and urine from autosomal dominant polycystic kidney disease patients. Journal of Internal Medicine. 276: 539-40. PMID 25205519 DOI: 10.1111/joim.12307  0.32
2014 Szalai AJ, Barnum SR, Ramos TN. Deletion of C-reactive protein ameliorates experimental cerebral malaria? Transactions of the Royal Society of Tropical Medicine and Hygiene. 108: 591-3. PMID 25002461 DOI: 10.1093/trstmh/tru098  0.32
2014 Bowling MR, Xing D, Kapadia A, Chen YF, Szalai AJ, Oparil S, Hage FG. Estrogen effects on vascular inflammation are age dependent: role of estrogen receptors. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 1477-85. PMID 24876352 DOI: 10.1161/ATVBAHA.114.303629  0.32
2014 Owsley C, Huisingh C, Jackson GR, Curcio CA, Szalai AJ, Dashti N, Clark M, Rookard K, McCrory MA, Wright TT, Callahan MA, Kline LB, Witherspoon CD, McGwin G. Associations between abnormal rod-mediated dark adaptation and health and functioning in older adults with normal macular health. Investigative Ophthalmology & Visual Science. 55: 4776-89. PMID 24854857 DOI: 10.1167/iovs.14-14502  0.32
2014 Szalai AJ, McCrory MA, Xing D, Hage FG, Miller A, Oparil S, Chen YF, Mazzone M, Early R, Henry SP, Zanardi TA, Graham MJ, Crooke RM. Inhibiting C-reactive protein for the treatment of cardiovascular disease: promising evidence from rodent models. Mediators of Inflammation. 2014: 353614. PMID 24803739 DOI: 10.1155/2014/353614  0.32
2014 Tang Y, Huang XR, Lv J, Chung ACK, Zhang Y, Chen JZ, Szalai AJ, Xu A, Lan HY. C-reactive protein promotes acute kidney injury by impairing G1/S-dependent tubular epithelium cell regeneration Clinical Science. 126: 645-659. PMID 24206243 DOI: 10.1042/CS20130471  0.32
2014 Ji Y, Fish PM, Strawn TL, Lohman AW, Wu J, Szalai AJ, Fay WP. C-reactive protein induces expression of tissue factor and plasminogen activator inhibitor-1 and promotes fibrin accumulation in vein grafts Journal of Thrombosis and Haemostasis. DOI: 10.1111/jth.12680  0.32
2013 Zhou Y, Wu J, Kucik DF, White NB, Redden DT, Szalai AJ, Bullard DC, Edberg JC. Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils. Arthritis and Rheumatism. 65: 2907-16. PMID 23918739 DOI: 10.1002/art.38117  0.32
2013 Pegues MA, McCrory MA, Zarjou A, Szalai AJ. C-reactive protein exacerbates renal ischemia-reperfusion injury. American Journal of Physiology. Renal Physiology. 304: F1358-65. PMID 23535585 DOI: 10.1152/ajprenal.00476.2012  0.32
2012 Jones NR, Pegues MA, McCrory MA, Singleton W, Bethune C, Baker BF, Norris DA, Crooke RM, Graham MJ, Szalai AJ. A Selective Inhibitor of Human C-reactive Protein Translation Is Efficacious In Vitro and in C-reactive Protein Transgenic Mice and Humans. Molecular Therapy. Nucleic Acids. 1: e52. PMID 23629027 DOI: 10.1038/mtna.2012.44  0.32
2012 Mukerji R, Mirza S, Roche AM, Widener RW, Croney CM, Rhee DK, Weiser JN, Szalai AJ, Briles DE. Pneumococcal surface protein A inhibits complement deposition on the pneumococcal surface by competing with the binding of C-reactive protein to cell-surface phosphocholine. Journal of Immunology (Baltimore, Md. : 1950). 189: 5327-35. PMID 23105137 DOI: 10.4049/jimmunol.1201967  0.32
2012 Ashraf AP, Fisher G, Alvarez J, Dudenbostel T, Calhoun DA, Szalai AJ, Gower BA. Associations of C-Reactive Protein to Indices of Vascular Health and the Influence of Serum 25(OH)D Status in Healthy Adults. Journal of Nutrition and Metabolism. 2012: 475975. PMID 23029606 DOI: 10.1155/2012/475975  0.32
2012 Zhou J, Ouyang X, Schoeb TR, Bolisetty S, Cui X, Mrug S, Yoder BK, Johnson MR, Szalai AJ, Mrug M. Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complement. Journal of the American Society of Nephrology : Jasn. 23: 1161-71. PMID 22518005 DOI: 10.1681/ASN.2011050442  0.32
2011 Liu F, Chen HY, Huang XR, Chung AC, Zhou L, Fu P, Szalai AJ, Lan HY. C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes. Diabetologia. 54: 2713-23. PMID 21744073 DOI: 10.1007/s00125-011-2237-y  0.36
2011 Jones NR, Pegues MA, McCrory MA, Kerr SW, Jiang H, Sellati R, Berger V, Villalona J, Parikh R, McFarland M, Pantages L, Madwed JB, Szalai AJ. Collagen-induced arthritis is exacerbated in C-reactive protein-deficient mice. Arthritis and Rheumatism. 63: 2641-50. PMID 21567377 DOI: 10.1002/art.30444  0.32
2011 Li ZI, Chung AC, Zhou L, Huang XR, Liu F, Fu P, Fan JM, Szalai AJ, Lan HY. C-reactive protein promotes acute renal inflammation and fibrosis in unilateral ureteral obstructive nephropathy in mice. Laboratory Investigation; a Journal of Technical Methods and Pathology. 91: 837-51. PMID 21383672 DOI: 10.1038/labinvest.2011.42  0.36
2011 Hu XZ, Wright TT, Jones NR, Ramos TN, Skibinski GA, McCrory MA, Barnum SR, Szalai AJ. Inhibition of Experimental Autoimmune Encephalomyelitis in Human C-Reactive Protein Transgenic Mice Is FcγRIIB Dependent. Autoimmune Diseases. 2011: 484936. PMID 21151582 DOI: 10.4061/2011/484936  0.32
2010 Li J, Wang JP, Ghiran I, Cerny A, Szalai AJ, Briles DE, Finberg RW. Complement receptor 1 expression on mouse erythrocytes mediates clearance of Streptococcus pneumoniae by immune adherence. Infection and Immunity. 78: 3129-35. PMID 20439480 DOI: 10.1128/IAI.01263-09  0.32
2010 Hage FG, Oparil S, Xing D, Chen YF, McCrory MA, Szalai AJ. C-reactive protein-mediated vascular injury requires complement. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 1189-95. PMID 20339115 DOI: 10.1161/ATVBAHA.110.205377  0.32
2010 Zhang R, Zhang YY, Huang XR, Wu Y, Chung AC, Wu EX, Szalai AJ, Wong BC, Lau CP, Lan HY. C-reactive protein promotes cardiac fibrosis and inflammation in angiotensin II-induced hypertensive cardiac disease. Hypertension. 55: 953-60. PMID 20157054 DOI: 10.1161/HYPERTENSIONAHA.109.140608  0.36
2009 Li J, Szalai AJ, Hollingshead SK, Nahm MH, Briles DE. Antibody to the type 3 capsule facilitates immune adherence of pneumococci to erythrocytes and augments their transfer to macrophages. Infection and Immunity. 77: 464-71. PMID 19001076 DOI: 10.1128/IAI.00892-08  0.32
2008 Li X, Su K, Ji C, Szalai AJ, Wu J, Zhang Y, Zhou T, Kimberly RP, Edberg JC. Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion. Journal of Immunology (Baltimore, Md. : 1950). 181: 1012-8. PMID 18606652  0.32
2008 Teoh H, Quan A, Lovren F, Wang G, Tirgari S, Szmitko PE, Szalai AJ, Ward ME, Verma S. Impaired endothelial function in C-reactive protein overexpressing mice. Atherosclerosis. 201: 318-25. PMID 18433756 DOI: 10.1016/j.atherosclerosis.2008.02.034  0.32
2008 Danenberg HD, Grad E, Swaminathan RV, Chen Z, Seifert P, Szalai AJ, Lotan C, Simon DI, Edelman ER. Neointimal formation is reduced after arterial injury in human crp transgenic mice. Atherosclerosis. 201: 85-91. PMID 18358478 DOI: 10.1016/j.atherosclerosis.2008.01.013  0.32
2008 Xing D, Hage FG, Chen YF, McCrory MA, Feng W, Skibinski GA, Majid-Hassan E, Oparil S, Szalai AJ. Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (Fc gamma RI)-dependent. The American Journal of Pathology. 172: 22-30. PMID 18063701 DOI: 10.2353/ajpath.2008.070154  0.32
2008 Mrug M, Zhou J, Woo Y, Cui X, Szalai AJ, Novak J, Churchill GA, Guay-Woodford LM. Overexpression of innate immune response genes in a model of recessive polycystic kidney disease Kidney International. 73: 63-76. PMID 17960140 DOI: 10.1038/sj.ki.5002627  0.32
2007 Li J, Glover DT, Szalai AJ, Hollingshead SK, Briles DE. PspA and PspC minimize immune adherence and transfer of pneumococci from erythrocytes to macrophages through their effects on complement activation. Infection and Immunity. 75: 5877-85. PMID 17923519 DOI: 10.1128/IAI.00839-07  0.32
2007 Szalai AJ, Hu X, Adams JE, Barnum SR. Complement in experimental autoimmune encephalomyelitis revisited: C3 is required for development of maximal disease. Molecular Immunology. 44: 3132-6. PMID 17353050 DOI: 10.1016/j.molimm.2007.02.002  0.32
2006 Chen K, Li F, Li J, Cai H, Strom S, Bisello A, Kelley DE, Friedman-Einat M, Skibinski GA, McCrory MA, Szalai AJ, Zhao AZ. Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nature Medicine. 12: 425-32. PMID 16582918 DOI: 10.1038/nm1372  0.32
2006 Read RW, Vogt SD, Barnum SR, Szalai AJ. Experimental autoimmune uveitis in the C57BL/6 mouse. Experimental Eye Research. 83: 229-30; author reply. PMID 16524572 DOI: 10.1016/j.exer.2005.10.028  0.32
2006 Barnum SR, Szalai AJ. Complement and demyelinating disease: no MAC needed? Brain Research Reviews. 52: 58-68. PMID 16443278 DOI: 10.1016/j.brainresrev.2005.12.002  0.32
2006 Osmers I, Szalai AJ, Tenner AJ, Barnum SR. Complement in BuB/BnJ mice revisited: serum C3 levels and complement opsonic activity are not elevated. Molecular Immunology. 43: 1722-5. PMID 16310250 DOI: 10.1016/j.molimm.2005.10.004  0.32
2006 Read RW, Szalai AJ, Vogt SD, McGwin G, Barnum SR. Genetic deficiency of C3 as well as CNS-targeted expression of the complement inhibitor sCrry ameliorates experimental autoimmune uveoretinitis. Experimental Eye Research. 82: 389-94. PMID 16143328 DOI: 10.1016/j.exer.2005.07.011  0.32
2005 Szalai AJ, Hu X, Raman C, Barnum SR. Requirement of the Fc receptor common gamma-chain for gamma delta T cell-mediated promotion of murine experimental autoimmune encephalomyelitis. European Journal of Immunology. 35: 3487-92. PMID 16278814 DOI: 10.1002/eji.200535285  0.32
2005 Barnum SR, Szalai AJ. Complement as a biomarker in multiple sclerosis. Journal of Neuropathology and Experimental Neurology. 64: 741. PMID 16106223  0.32
2005 Boos L, Szalai AJ, Barnum SR. C3a expressed in the central nervous system protects against LPS-induced shock. Neuroscience Letters. 387: 68-71. PMID 16085360 DOI: 10.1016/j.neulet.2005.07.015  0.32
2005 Wang D, Oparil S, Chen YF, McCrory MA, Skibinski GA, Feng W, Szalai AJ. Estrogen treatment abrogates neointima formation in human C-reactive protein transgenic mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 2094-9. PMID 16051879 DOI: 10.1161/01.ATV.0000179602.85797.3f  0.32
2005 Szalai AJ, Alarcón GS, Calvo-Alén J, Toloza SMA, McCrory MA, Edberg JC, McGwin G, Bastian HM, Fessler BJ, Vilá LM, Kimberly RP, Reveille JD. Systemic lupus erythematosus in a multiethnic US Cohort (LUMINA). XXX: Association between C-reactive protein (CRP) gene polymorphisms and vascular events Rheumatology. 44: 864-868. PMID 15797975 DOI: 10.1093/rheumatology/keh613  0.32
2005 Szalai AJ, Wu J, Lange EM, McCrory MA, Langefeld CD, Williams A, Zakharkin SO, George V, Allison DB, Cooper GS, Xie F, Fan Z, Edberg JC, Kimberly RP. Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level. Journal of Molecular Medicine (Berlin, Germany). 83: 440-7. PMID 15778807 DOI: 10.1007/s00109-005-0658-0  0.32
2005 Verschuren L, Kleemann R, Offerman EH, Szalai AJ, Emeis SJ, Princen HM, Kooistra T. Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 161-7. PMID 15514207 DOI: 10.1161/01.ATV.0000148866.29829.19  0.32
2005 Boos LA, Szalai AJ, Barnum SR. Murine complement C4 is not required for experimental autoimmune encephalomyelitis. Glia. 49: 158-60. PMID 15390104 DOI: 10.1002/glia.20093  0.32
2004 Ren B, McCrory MA, Pass C, Bullard DC, Ballantyne CM, Xu Y, Briles DE, Szalai AJ. The virulence function of Streptococcus pneumoniae surface protein A involves inhibition of complement activation and impairment of complement receptor-mediated protection. Journal of Immunology (Baltimore, Md. : 1950). 173: 7506-12. PMID 15585877  0.32
2004 Szalai AJ, Barnum SR. Fc receptors and the common gamma-chain in experimental autoimmune encephalomyelitis. Journal of Neuroscience Research. 75: 597-602. PMID 14991835 DOI: 10.1002/jnr.20023  0.32
2004 Kleemann R, Verschuren L, de Rooij BJ, Lindeman J, de Maat MM, Szalai AJ, Princen HM, Kooistra T. Evidence for anti-inflammatory activity of statins and PPARalpha activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro. Blood. 103: 4188-94. PMID 14976045 DOI: 10.1182/blood-2003-11-3791  0.32
2004 Paul A, Ko KW, Li L, Yechoor V, McCrory MA, Szalai AJ, Chan L. C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Circulation. 109: 647-55. PMID 14744975 DOI: 10.1161/01.CIR.0000114526.50618.24  0.32
2004 Ren B, Szalai AJ, Hollingshead SK, Briles DE. Effects of PspA and antibodies to PspA on activation and deposition of complement on the pneumococcal surface. Infection and Immunity. 72: 114-22. PMID 14688088 DOI: 10.1128/IAI.72.1.114-122.2004  0.32
2003 Danenberg HD, Szalai AJ, Swaminathan RV, Peng L, Chen Z, Seifert P, Fay WP, Simon DI, Edelman ER. Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice. Circulation. 108: 512-5. PMID 12874178 DOI: 10.1161/01.CIR.0000085568.13915.1E  0.32
2003 Xu Y, Szalai AJ, Zhou T, Zinn KR, Chaudhuri TR, Li X, Koopman WJ, Kimberly RP. Fc gamma Rs modulate cytotoxicity of anti-Fas antibodies: implications for agonistic antibody-based therapeutics. Journal of Immunology (Baltimore, Md. : 1950). 171: 562-8. PMID 12847219 DOI: 10.4049/jimmunol.171.2.562  0.32
2003 Szalai AJ, Weaver CT, McCrory MA, van Ginkel FW, Reiman RM, Kearney JF, Marion TN, Volanakis JE. Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene. Arthritis and Rheumatism. 48: 1602-11. PMID 12794828 DOI: 10.1002/art.11026  0.32
2003 Ren B, Szalai AJ, Thomas O, Hollingshead SK, Briles DE. Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae. Infection and Immunity. 71: 75-85. PMID 12496151 DOI: 10.1128/IAI.71.1.75-85.2003  0.32
2002 Szalai AJ, McCrory MA. Varied biologic functions of C-reactive protein: lessons learned from transgenic mice. Immunologic Research. 26: 279-87. PMID 12403365 DOI: 10.1385/IR:26:1-3:279  0.32
2002 Szalai AJ, Nataf S, Hu XZ, Barnum SR. Experimental allergic encephalomyelitis is inhibited in transgenic mice expressing human C-reactive protein. Journal of Immunology (Baltimore, Md. : 1950). 168: 5792-7. PMID 12023381  0.32
2002 Szalai AJ, McCrory MA, Cooper GS, Wu J, Kimberly RP. Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene Genes and Immunity. 3: 14-19. PMID 11857055 DOI: 10.1038/sj.gene.6363820  0.32
2000 Nataf S, Carroll SL, Wetsel RA, Szalai AJ, Barnum SR. Attenuation of experimental autoimmune demyelination in complement-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 165: 5867-73. PMID 11067947 DOI: 10.4049/jimmunol.165.10.5867  0.32
2000 Szalai AJ, Digerness SB, Agrawal A, Kearney JF, Bucy RP, Niwas S, Kilpatrick JM, Babu YS, Volanakis JE. The Arthus reaction in rodents: species-specific requirement of complement. Journal of Immunology (Baltimore, Md. : 1950). 164: 463-8. PMID 10605043 DOI: 10.4049/jimmunol.164.1.463  0.32
1999 Tu AHT, Fulgham RL, Mccrory MA, Briles DE, Szalai AJ. Pneumococcal surface protein A inhibits complement activation by Streptococcus pneumoniae Infection and Immunity. 67: 4720-4724. PMID 10456922  0.32
1999 O'Brien DP, Briles DE, Szalai AJ, Tu AH, Sanz I, Nahm MH. Tumor necrosis factor alpha receptor I is important for survival from Streptococcus pneumoniae infections Infection and Immunity. 67: 595-601. PMID 9916064  0.32
1997 Briles DE, Hollingshead SK, Swiatlo E, Brooks-Walter A, Szalai A, Virolainen A, McDaniel LS, Benton KA, White P, Prellner K, Hermansson A, Aerts PC, Van Dijk H, Crain MJ. PspA and PspC: their potential for use as pneumococcal vaccines. Microbial Drug Resistance (Larchmont, N.Y.). 3: 401-8. PMID 9442494 DOI: 10.1089/mdr.1997.3.401  0.32
1996 Szalai AJ, Briles DE, Volanakis JE. Role of complement in C-reactive-protein-mediated protection of mice from Streptococcus pneumoniae Infection and Immunity. 64: 4850-4853. PMID 8890251  0.32
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