Adrie J. Steyn - Publications

Affiliations: 
Microbiology University of Alabama, Birmingham, Birmingham, AL, United States 
Area:
Microbiology Biology

38/58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Cumming BM, Reddy VP, Steyn AJC. The Analysis of Mycobacterium tuberculosis-Induced Bioenergetic Changes in Infected Macrophages Using an Extracellular Flux Analyzer. Methods in Molecular Biology (Clifton, N.J.). 2184: 161-184. PMID 32808225 DOI: 10.1007/978-1-0716-0802-9_12  0.36
2020 Fernández-García M, Rey-Stolle F, Boccard J, Reddy VP, García A, Cumming BM, Steyn AJC, Rudaz S, Barbas C. Comprehensive examination of the mouse lung metabolome following infection using a multiplatform mass spectrometry approach. Journal of Proteome Research. PMID 32285670 DOI: 10.1021/acs.jproteome.9b00868  0.36
2020 Rahman MA, Cumming BM, Addicott KW, Pacl HT, Russell SL, Nargan K, Naidoo T, Ramdial PK, Adamson JH, Wang R, Steyn AJC. Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 32139610 DOI: 10.1073/pnas.1919211117  0.36
2020 Saini V, Chinta KC, Reddy VP, Glasgow JN, Stein A, Lamprecht DA, Rahman MA, Mackenzie JS, Truebody BE, Adamson JH, Kunota TTR, Bailey SM, Moellering DR, Lancaster JR, Steyn AJC. Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis. Nature Communications. 11: 557. PMID 31992699 DOI: 10.1038/s41467-019-14132-y  0.48
2019 Russell SL, Lamprecht DA, Mandizvo T, Jones TT, Naidoo V, Addicott KW, Moodley C, Ngcobo B, Crossman DK, Wells G, Steyn AJC. Compromised Metabolic Reprogramming Is an Early Indicator of CD8 T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection. Cell Reports. 29: 3564-3579.e5. PMID 31825836 DOI: 10.1016/j.celrep.2019.11.034  0.48
2019 Chinta KC, Rahman MA, Saini V, Glasgow JN, Reddy VP, Lever JM, Nhamoyebonde S, Leslie A, Wells RM, Traylor A, Madansein R, Siegal GP, Antony VB, Deshane J, Wells G, ... ... Steyn AJC, et al. Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis. Cell Reports. 28: 3286. PMID 31533049 DOI: 10.1016/j.celrep.2019.08.081  0.48
2019 Ardain A, Domingo-Gonzalez R, Das S, Kazer SW, Howard NC, Singh A, Ahmed M, Nhamoyebonde S, Rangel-Moreno J, Ogongo P, Lu L, Ramsuran D, de la Luz Garcia-Hernandez M, Ulland TK, Darby M, ... ... Steyn A, et al. Publisher Correction: Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis. Nature. PMID 31337923 DOI: 10.1038/s41586-019-1458-y  0.52
2018 Chinta KC, Rahman MA, Saini V, Glasgow JN, Reddy VP, Lever JM, Nhamoyebonde S, Leslie A, Wells RM, Traylor A, Madansein R, Siegal GP, Antony VB, Deshane J, Wells G, ... ... Steyn AJC, et al. Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis. Cell Reports. 25: 1938-1952.e5. PMID 30428359 DOI: 10.1016/j.celrep.2018.10.073  0.48
2018 Pacl HT, Reddy VP, Saini V, Chinta KC, Steyn AJC. Host-pathogen redox dynamics modulate Mycobacterium tuberculosis pathogenesis. Pathogens and Disease. 76. PMID 29873719 DOI: 10.1093/femspd/fty036  0.48
2018 Reddy VP, Chinta KC, Saini V, Glasgow JN, Hull TD, Traylor A, Rey-Stolle F, Soares MP, Madansein R, Rahman MA, Barbas C, Nargan K, Naidoo T, Ramdial PK, George JF, ... ... Steyn AJC, et al. Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Infection. Frontiers in Immunology. 9: 860. PMID 29774023 DOI: 10.3389/fimmu.2018.00860  0.48
2017 Cumming BM, Chinta KC, Reddy VP, Steyn AJ. Role of ergothioneine in microbial physiology and pathogenesis. Antioxidants & Redox Signaling. PMID 28791878 DOI: 10.1089/ars.2017.7300  0.36
2017 Cumming BM, Rahman MA, Lamprecht DA, Rohde KH, Saini V, Adamson JH, Russell DG, Steyn AJC. Correction: Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection. Plos Pathogens. 13: e1006490. PMID 28708888 DOI: 10.1371/journal.ppat.1006490  0.48
2017 Cumming BM, Rahman MA, Lamprecht DA, Rohde KH, Saini V, Adamson JH, Russell DG, Steyn AJC. Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection. Plos Pathogens. 13: e1006389. PMID 28542477 DOI: 10.1371/journal.ppat.1006389  0.48
2016 Chen Z, Hu Y, Cumming BM, Lu P, Feng L, Deng J, Steyn AJ, Chen S. Mycobacterial WhiB6 Differentially Regulates ESX-1 and the Dos Regulon to Modulate Granuloma Formation and Virulence in Zebrafish. Cell Reports. PMID 27545883 DOI: 10.1016/j.celrep.2016.07.080  0.52
2016 Lamprecht DA, Finin PM, Rahman MA, Cumming BM, Russell SL, Jonnala SR, Adamson JH, Steyn AJ. Turning the respiratory flexibility of Mycobacterium tuberculosis against itself. Nature Communications. 7: 12393. PMID 27506290 DOI: 10.1038/ncomms12393  0.52
2016 Chinta KC, Saini V, Glasgow JN, Mazorodze JH, Rahman MA, Reddy D, Lancaster JR, Steyn AJ. The emerging role of gasotransmitters in the pathogenesis of tuberculosis. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. PMID 27387335 DOI: 10.1016/j.niox.2016.06.009  0.52
2016 Saini V, Cumming BM, Guidry L, Lamprecht DA, Adamson JH, Reddy VP, Chinta KC, Mazorodze JH, Glasgow JN, Richard-Greenblatt M, Gomez-Velasco A, Bach H, Av-Gay Y, Eoh H, Rhee K, ... Steyn AJ, et al. Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis. Cell Reports. 14: 572-85. PMID 26774486 DOI: 10.1016/j.celrep.2015.12.056  0.48
2015 Cumming BM, Steyn AJ. Metabolic plasticity of central carbon metabolism protects mycobacteria. Proceedings of the National Academy of Sciences of the United States of America. 112: 13135-6. PMID 26483480 DOI: 10.1073/pnas.1518171112  0.52
2015 Richard-Greenblatt M, Bach H, Adamson J, Peña-Diaz S, Li W, Steyn AJ, Av-Gay Y. Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium tuberculosis Growth and Infectivity. The Journal of Biological Chemistry. 290: 23064-76. PMID 26229105 DOI: 10.1074/jbc.M115.648642  0.52
2015 Saini V, Cumming BM, Guidry L, Lamprecht DA, Adamson JH, Reddy VP, Chinta KC, Mazorodze JH, Glasgow JN, Richard-Greenblatt M, Gomez-Velasco A, Bach H, Av-Gay Y, Eoh H, Rhee K, ... Steyn AJC, et al. Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis Cell Reports. DOI: 10.1016/j.celrep.2015.12.056  0.52
2014 Cumming BM, Lamprecht DA, Wells RM, Saini V, Mazorodze JH, Steyn AJ. The Physiology and Genetics of Oxidative Stress in Mycobacteria. Microbiology Spectrum. 2. PMID 26103972 DOI: 10.1128/microbiolspec.MGM2-0019-2013  0.52
2014 Wang Y, Jin TH, Farhana A, Freeman J, Estell K, Zmijewski JW, Gaggar A, Thannickal VJ, Schwiebert LM, Steyn AJ, Deshane JS. Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness. Laboratory Investigation; a Journal of Technical Methods and Pathology. 94: 1312-25. PMID 25365203 DOI: 10.1038/labinvest.2014.126  0.52
2013 Gopal R, Monin L, Torres D, Slight S, Mehra S, McKenna KC, Fallert Junecko BA, Reinhart TA, Kolls J, Báez-Saldaña R, Cruz-Lagunas A, Rodríguez-Reyna TS, Kumar NP, Tessier P, Roth J, ... ... Steyn AJ, et al. S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis. American Journal of Respiratory and Critical Care Medicine. 188: 1137-46. PMID 24047412 DOI: 10.1164/rccm.201304-0803OC  0.52
2013 Steyn AJC, Mai D, Saini V, Farhana A. Protein-protein interaction in the-omics era: Understanding Mycobacterium tuberculosis function Systems Biology of Tuberculosis. 79-106. DOI: 10.1007/978-1-4614-4966-9_5  0.52
2012 Chawla M, Parikh P, Saxena A, Munshi M, Mehta M, Mai D, Srivastava AK, Narasimhulu KV, Redding KE, Vashi N, Kumar D, Steyn AJ, Singh A. Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo. Molecular Microbiology. 85: 1148-65. PMID 22780904 DOI: 10.1111/j.1365-2958.2012.08165.x  0.52
2012 Farhana A, Saini V, Kumar A, Lancaster JR, Steyn AJ. Environmental heme-based sensor proteins: implications for understanding bacterial pathogenesis. Antioxidants & Redox Signaling. 17: 1232-45. PMID 22494151 DOI: 10.1089/ars.2012.4613  0.52
2012 Saini V, Farhana A, Glasgow JN, Steyn AJ. Iron sulfur cluster proteins and microbial regulation: implications for understanding tuberculosis. Current Opinion in Chemical Biology. 16: 45-53. PMID 22483328 DOI: 10.1016/j.cbpa.2012.03.004  0.52
2012 Saini V, Farhana A, Steyn AJ. Mycobacterium tuberculosis WhiB3: a novel iron-sulfur cluster protein that regulates redox homeostasis and virulence. Antioxidants & Redox Signaling. 16: 687-97. PMID 22010944 DOI: 10.1089/ars.2011.4341  0.52
2011 Kumar A, Farhana A, Guidry L, Saini V, Hondalus M, Steyn AJ. Redox homeostasis in mycobacteria: the key to tuberculosis control? Expert Reviews in Molecular Medicine. 13: e39. PMID 22172201 DOI: 10.1017/S1462399411002079  0.52
2011 Mai D, Jones J, Rodgers JW, Hartman JL, Kutsch O, Steyn AJ. A screen to identify small molecule inhibitors of protein-protein interactions in mycobacteria. Assay and Drug Development Technologies. 9: 299-310. PMID 21281130 DOI: 10.1089/adt.2010.0326  0.52
2010 Farhana A, Guidry L, Srivastava A, Singh A, Hondalus MK, Steyn AJ. Reductive stress in microbes: implications for understanding Mycobacterium tuberculosis disease and persistence. Advances in Microbial Physiology. 57: 43-117. PMID 21078441 DOI: 10.1016/B978-0-12-381045-8.00002-3  0.52
2010 Callahan B, Nguyen K, Collins A, Valdes K, Caplow M, Crossman DK, Steyn AJ, Eisele L, Derbyshire KM. Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspA. Journal of Bacteriology. 192: 326-35. PMID 19854905 DOI: 10.1128/JB.01032-09  0.52
2009 Singh A, Crossman DK, Mai D, Guidry L, Voskuil MI, Renfrow MB, Steyn AJ. Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response. Plos Pathogens. 5: e1000545. PMID 19680450 DOI: 10.1371/journal.ppat.1000545  0.52
2008 Kumar A, Deshane JS, Crossman DK, Bolisetty S, Yan BS, Kramnik I, Agarwal A, Steyn AJ. Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon. The Journal of Biological Chemistry. 283: 18032-9. PMID 18400743 DOI: 10.1074/jbc.M802274200  0.52
2007 Hett EC, Chao MC, Steyn AJ, Fortune SM, Deng LL, Rubin EJ. A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis. Molecular Microbiology. 66: 658-68. PMID 17919286 DOI: 10.1111/j.1365-2958.2007.05945.x  0.52
2007 Singh A, Guidry L, Narasimhulu KV, Mai D, Trombley J, Redding KE, Giles GI, Lancaster JR, Steyn AJ. Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival. Proceedings of the National Academy of Sciences of the United States of America. 104: 11562-7. PMID 17609386 DOI: 10.1073/pnas.0700490104  0.52
2007 Kumar A, Toledo JC, Patel RP, Lancaster JR, Steyn AJ. Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor. Proceedings of the National Academy of Sciences of the United States of America. 104: 11568-73. PMID 17609369 DOI: 10.1073/pnas.0705054104  0.52
2006 Singh A, Mai D, Kumar A, Steyn AJ. Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein association. Proceedings of the National Academy of Sciences of the United States of America. 103: 11346-51. PMID 16844784 DOI: 10.1073/pnas.0602817103  0.52
Low-probability matches
2020 Cumming BM, Pacl HT, Steyn AJC. Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy. Frontiers in Cellular and Infection Microbiology. 10: 576596. PMID 33072629 DOI: 10.3389/fcimb.2020.576596  0.28
2020 Lupien A, Foo CS, Savina S, Vocat A, Piton J, Monakhova N, Benjak A, Lamprecht DA, Steyn AJC, Pethe K, Makarov VA, Cole ST. New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis. Plos Pathogens. 16: e1008270. PMID 31971990 DOI: 10.1371/journal.ppat.1008270  0.28
2018 Foo CS, Lupien A, Kienle M, Vocat A, Benjak A, Sommer R, Lamprecht DA, Steyn AJC, Pethe K, Piton J, Altmann KH, Cole ST. Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis. Mbio. 9. PMID 30301850 DOI: 10.1128/mBio.01276-18  0.28
2018 Wang Z, Cumming BM, Mao C, Zhu Y, Lu P, Steyn AJC, Chen S, Hu Y. RbpA and σassociation regulates polyphosphate levels to modulate mycobacterial isoniazid-tolerance. Molecular Microbiology. PMID 29575247 DOI: 10.1111/mmi.13952  0.28
2018 Murugesan D, Ray PC, Bayliss T, Prosser GA, Harrison JR, Green K, Soares de Melo C, Feng TS, Street LJ, Chibale K, Warner DF, Mizrahi V, Epemolu O, Scullion P, Ellis L, ... ... Steyn AJC, et al. 2-Mercapto-quinazolinones as inhibitors of NDH-2 and Mycobacterium tuberculosis: Structure-activity relationships, mechanism of action and ADME characterization. Acs Infectious Diseases. PMID 29522317 DOI: 10.1021/acsinfecdis.7b00275  0.28
2017 Moosa A, Lamprecht DA, Arora K, Barry CE, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V, Warner DF. Susceptibility of Mycobacterium tuberculosis cytochrome bd oxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c. Antimicrobial Agents and Chemotherapy. PMID 28760899 DOI: 10.1128/AAC.01338-17  0.28
2002 Steyn AJ, Collins DM, Hondalus MK, Jacobs WR, Kawakami RP, Bloom BR. Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth. Proceedings of the National Academy of Sciences of the United States of America. 99: 3147-52. PMID 11880648 DOI: 10.1073/pnas.052705399  0.12
2018 Frank DJ, Horne DJ, Dutta NK, Shaku MT, Madensein R, Hawn TR, Steyn AJC, Karakousis PC, Kana BD, Meintjes G, Laughon B, Tanvir Z. Remembering the Host in Tuberculosis Drug Development. The Journal of Infectious Diseases. PMID 30590592 DOI: 10.1093/infdis/jiy712  0.08
2019 Ogongo P, Steyn AJ, Karim F, Dullabh KJ, Awala I, Madansein R, Leslie A, Behar SM. Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs. The Journal of Clinical Investigation. PMID 31763997 DOI: 10.1172/JCI130711  0.04
2016 Surolia R, Karki S, Wang Z, Kulkarni T, Li FJ, Vohra S, Batra H, Nick JA, Duncan SR, Thannickal VJ, Steyn AJ, Agarwal A, Antony VB. Attenuated Heme Oxygenase-1 Responses Predispose the Elderly To Pulmonary Non Tuberculous Mycobacterial Infections. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00397.2015. PMID 27694475 DOI: 10.1152/ajplung.00397.2015  0.04
2020 Dunlap MD, Prince OA, Rangel-Moreno J, Thomas KA, Scordo JM, Torrelles JB, Cox J, Steyn AJC, Zúñiga J, Kaushal D, Khader SA. Formation of Lung Inducible Bronchus Associated Lymphoid Tissue Is Regulated by Expressed Determinants. Frontiers in Immunology. 11: 1325. PMID 32695111 DOI: 10.3389/fimmu.2020.01325  0.01
2019 Joubert BR, Berhane K, Chevrier J, Collman G, Eskenazi B, Fobil J, Hoyo C, John CC, Kumie A, Nicol M, Ramsay M, Smith J, Steyn A, Tshala-Katumbay D, McAllister K. Integrating environmental health and genomics research in Africa: challenges and opportunities identified during a Human Heredity and Health in Africa (H3Africa) Consortium workshop. Aas Open Research. 2: 159. PMID 32382703 DOI: 10.12688/aasopenres.12983.1  0.01
2018 Beteck RM, Seldon R, Coertzen D, van der Watt ME, Reader J, Mackenzie JS, Lamprecht DA, Abraham M, Eribez K, Müller J, Rui F, Zhu G, de Grano RV, Williams ID, Smit FJ, ... Steyn AJC, et al. Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites Communications Chemistry. 1. DOI: 10.1038/s42004-018-0062-7  0.01
2015 Saini V, Stein A, Chinta KC, Reddy VP, Lamprecht DA, Bailey SM, Glasgow JN, Moellering DR, Steyn AJ. Hydrogen Sulfide Alters M. Tuberculosis Bioenergetics and Promotes Tuberculosis Disease Free Radical Biology and Medicine. 87: S141. DOI: 10.1016/j.freeradbiomed.2015.10.365  0.01
2014 Saini V, Farhana A, Kumar R, Osborn J, Chaytanya Chinta K, Freeman J, Glasgow JN, Lefkowitz EJ, Steyn AJ. Exposure to Cigarette Smoke Causes DNA Damage and Contributes to Drug Resistance in Mycobacterium Tuberculosis Free Radical Biology and Medicine. 76: S166-S167. DOI: 10.1016/j.freeradbiomed.2014.10.056  0.01
2013 Saini V, Steyn A, Chinta KC, Moellering DR, Bailey SM, Steyn AJ. Mechanistic Insights into the Role of Hydrogen Sulfide in Mycobacterial Disease and Persistence Free Radical Biology and Medicine. 65: S62. DOI: 10.1016/j.freeradbiomed.2013.10.538  0.01
2007 Steyn AJ, Chan J, Mehra V. Recent developments in mycobacterial research. Current Opinion in Infectious Diseases. 12: 415-24. PMID 17035806 DOI: 10.1097/00001432-199910000-00002  0.01
2003 Steyn AJ, Joseph J, Bloom BR. Interaction of the sensor module of Mycobacterium tuberculosis H37Rv KdpD with members of the Lpr family. Molecular Microbiology. 47: 1075-89. PMID 12581360  0.01
2000 Alland D, Steyn AJ, Weisbrod T, Aldrich K, Jacobs WR. Characterization of the Mycobacterium tuberculosis iniBAC promoter, a promoter that responds to cell wall biosynthesis inhibition. Journal of Bacteriology. 182: 1802-11. PMID 10714983 DOI: 10.1128/JB.182.7.1802-1811.2000  0.01
1988 Steyn AC, Pretorius GH. A physical analysis of the prophage of Proteus mirabilis PM5006. The Journal of General Virology. 2909-12. PMID 2824668 DOI: 10.1099/0022-1317-68-11-2909  0.01
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