Deborah T. Hung - Publications

Biology, Molecular and Cellular Harvard University, Cambridge, MA, United States 
Biochemistry, Microbiology Biology

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Poulsen BE, Yang R, Clatworthy AE, White T, Osmulski SJ, Li L, Penaranda C, Lander ES, Shoresh N, Hung DT. Defining the core essential genome of . Proceedings of the National Academy of Sciences of the United States of America. PMID 31036669 DOI: 10.1073/pnas.1900570116  0.6
2019 Bhattacharyya RP, Walker M, Boykin R, Son SS, Liu J, Hachey AC, Ma P, Wu L, Choi K, Cummins KC, Benson M, Skerry J, Ryu H, Wong SY, Goldberg MB, ... ... Hung DT, et al. Rapid identification and phylogenetic classification of diverse bacterial pathogens in a multiplexed hybridization assay targeting ribosomal RNA. Scientific Reports. 9: 4516. PMID 30872641 DOI: 10.1038/s41598-019-40792-3  0.52
2018 Fang C, Lee KK, Nietupski R, Bates RH, Fernandez-Menendez R, Lopez-Roman EM, Guijarro-Lopez L, Yin Y, Peng Z, Gomez JE, Fisher S, Barros-Aguirre D, Hubbard BK, Serrano-Wu MH, Hung DT. Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 30316633 DOI: 10.1016/j.bmcl.2018.09.037  0.52
2018 Bhattacharyya RP, Thakku SG, Hung DT. Harnessing CRISPR Effectors for Infectious Disease Diagnostics. Acs Infectious Diseases. PMID 30113801 DOI: 10.1021/acsinfecdis.8b00170  0.52
2018 Clatworthy AE, Romano KP, Hung DT. Whole-organism phenotypic screening for anti-infectives promoting host health. Nature Chemical Biology. PMID 29556098 DOI: 10.1038/s41589-018-0018-3  0.6
2018 Wellington S, Hung DT. The expanding diversity of Mycobacterium tuberculosis drug targets. Acs Infectious Diseases. PMID 29412643 DOI: 10.1021/acsinfecdis.7b00255  0.52
2017 Wellington S, Nag PP, Michalska K, Johnston SE, Jedrzejczak RP, Kaushik VK, Clatworthy AE, Siddiqi N, McCarren P, Bajrami B, Maltseva NI, Combs S, Fisher SL, Joachimiak A, Schreiber SL, ... Hung DT, et al. A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nature Chemical Biology. PMID 28671682 DOI: 10.1038/nchembio.2420  0.6
2017 Barczak AK, Avraham R, Singh S, Luo SS, Zhang WR, Bray MA, Hinman AE, Thompson M, Nietupski RM, Golas A, Montgomery P, Fitzgerald M, Smith RS, White DW, Tischler AD, ... ... Hung DT, et al. Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence. Plos Pathogens. 13: e1006363. PMID 28505176 DOI: 10.1371/journal.ppat.1006363  0.48
2017 Gootenberg JS, Abudayyeh OO, Lee JW, Essletzbichler P, Dy AJ, Joung J, Verdine V, Donghia N, Daringer NM, Freije CA, Myhrvold C, Bhattacharyya RP, Livny J, Regev A, Koonin EV, ... Hung DT, et al. Nucleic acid detection with CRISPR-Cas13a/C2c2. Science (New York, N.Y.). PMID 28408723 DOI: 10.1126/science.aam9321  0.52
2017 Gomez JE, Kaufmann-Malaga BB, Wivagg CN, Kim PB, Silvis MR, Renedo N, Ioerger TR, Ahmad R, Livny J, Fishbein S, Sacchettini JC, Carr SA, Hung DT. Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment. Elife. 6. PMID 28220755 DOI: 10.7554/eLife.20420  1
2016 Wivagg CN, Wellington S, Gomez JE, Hung DT. Loss of a Class A Penicillin-Binding Protein Alters β-Lactam Susceptibilities in Mycobacterium tuberculosis. Acs Infectious Diseases. 2: 104-10. PMID 27624961 DOI: 10.1021/acsinfecdis.5b00119  1
2016 Zhang D, Gomez JE, Chien JY, Haseley N, Desjardins CA, Earl AM, Hsueh PR, Hung DT. Genomic analysis of the evolution of fluoroquinolone resistance in Mycobacterium tuberculosis prior to tuberculosis diagnosis. Antimicrobial Agents and Chemotherapy. PMID 27572408 DOI: 10.1128/AAC.00664-16  0.52
2016 Avraham R, Haseley N, Fan A, Bloom-Ackermann Z, Livny J, Hung DT. A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes. Nature Protocols. 11: 1477-1491. PMID 27442864 DOI: 10.1038/nprot.2016.090  0.4
2016 Grant SS, Wellington S, Kawate T, Desjardins CA, Silvis MR, Wivagg C, Thompson M, Gordon K, Kazyanskaya E, Nietupski R, Haseley N, Iwase N, Earl AM, Fitzgerald M, Hung DT. Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors. Cell Chemical Biology. PMID 27321573 DOI: 10.1016/j.chembiol.2016.05.011  1
2015 Avraham R, Haseley N, Brown D, Penaranda C, Jijon HB, Trombetta JJ, Satija R, Shalek AK, Xavier RJ, Regev A, Hung DT. Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses. Cell. 162: 1309-21. PMID 26343579 DOI: 10.1016/j.cell.2015.08.027  1
2015 Hou HW, Bhattacharyya RP, Hung DT, Han J. Direct detection and drug-resistance profiling of bacteremias using inertial microfluidics. Lab On a Chip. 15: 2297-307. PMID 25882432 DOI: 10.1039/c5lc00311c  1
2015 Shishkin AA, Giannoukos G, Kucukural A, Ciulla D, Busby M, Surka C, Chen J, Bhattacharyya RP, Rudy RF, Patel MM, Novod N, Hung DT, Gnirke A, Garber M, Guttman M, et al. Simultaneous generation of many RNA-seq libraries in a single reaction. Nature Methods. 12: 323-5. PMID 25730492 DOI: 10.1038/nmeth.3313  0.52
2014 Wivagg CN, Bhattacharyya RP, Hung DT. Mechanisms of β-lactam killing and resistance in the context of Mycobacterium tuberculosis. The Journal of Antibiotics. 67: 645-54. PMID 25052484 DOI: 10.1038/ja.2014.94  1
2014 Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT. Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. Plos Pathogens. 10: e1003946. PMID 24586159 DOI: 10.1371/journal.ppat.1003946  1
2014 Slater LH, Clatworthy AE, Hung DT. Bacterial toxins and small molecules elucidate endosomal trafficking. Trends in Microbiology. 22: 53-5. PMID 24370463 DOI: 10.1016/j.tim.2013.12.002  0.6
2013 Kawate T, Iwase N, Shimizu M, Stanley SA, Wellington S, Kazyanskaya E, Hung DT. Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32. Bioorganic & Medicinal Chemistry Letters. 23: 6052-9. PMID 24103299 DOI: 10.1016/j.bmcl.2013.09.035  1
2013 Grant SS, Kawate T, Nag PP, Silvis MR, Gordon K, Stanley SA, Kazyanskaya E, Nietupski R, Golas A, Fitzgerald M, Cho S, Franzblau SG, Hung DT. Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model. Acs Chemical Biology. 8: 2224-34. PMID 23898841 DOI: 10.1021/cb4004817  1
2013 Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, Aquadro JA, Grant SS, Rubin EJ, Hung DT. Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32. Proceedings of the National Academy of Sciences of the United States of America. 110: 11565-70. PMID 23798446 DOI: 10.1073/pnas.1302114110  1
2013 Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 9932-7. PMID 23716698 DOI: 10.1073/pnas.1302257110  1
2013 Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT. Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nature Chemical Biology. 9: 398-405. PMID 23603659 DOI: 10.1038/nchembio.1236  1
2013 Grant SS, Hung DT. Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response. Virulence. 4: 273-83. PMID 23563389 DOI: 10.4161/viru.23987  0.4
2013 Slater LH, Hett EC, Mark K, Chumbler NM, Patel D, Lacy DB, Collier RJ, Hung DT. Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death. Acs Chemical Biology. 8: 812-22. PMID 23343607 DOI: 10.1021/cb300555n  1
2012 Grad YH, Lipsitch M, Griggs AD, Haas BJ, Shea TP, McCowan C, Montmayeur A, FitzGerald M, Wortman JR, Krogfelt KA, Bingen E, Weill FX, Tietze E, Flieger A, Lander ES, ... ... Hung DT, et al. Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany. Proceedings of the National Academy of Sciences of the United States of America. 109: E3629-30. PMID 23479789 DOI: 10.1073/pnas.1209419110  1
2012 Chand NS, Clatworthy AE, Hung DT. The two-component sensor KinB acts as a phosphatase to regulate Pseudomonas aeruginosa Virulence. Journal of Bacteriology. 194: 6537-47. PMID 23024348 DOI: 10.1128/JB.01168-12  1
2012 Grant SS, Kaufmann BB, Chand NS, Haseley N, Hung DT. Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals. Proceedings of the National Academy of Sciences of the United States of America. 109: 12147-52. PMID 22778419 DOI: 10.1073/pnas.1203735109  1
2012 Stanley SA, Grant SS, Kawate T, Iwase N, Shimizu M, Wivagg C, Silvis M, Kazyanskaya E, Aquadro J, Golas A, Fitzgerald M, Dai H, Zhang L, Hung DT. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. Acs Chemical Biology. 7: 1377-84. PMID 22577943 DOI: 10.1021/cb300151m  1
2012 Barczak AK, Gomez JE, Kaufmann BB, Hinson ER, Cosimi L, Borowsky ML, Onderdonk AB, Stanley SA, Kaur D, Bryant KF, Knipe DM, Sloutsky A, Hung DT. RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities. Proceedings of the National Academy of Sciences of the United States of America. 109: 6217-22. PMID 22474362 DOI: 10.1073/pnas.1119540109  1
2012 Grad YH, Lipsitch M, Feldgarden M, Arachchi HM, Cerqueira GC, Fitzgerald M, Godfrey P, Haas BJ, Murphy CI, Russ C, Sykes S, Walker BJ, Wortman JR, Young S, Zeng Q, ... ... Hung DT, et al. Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011. Proceedings of the National Academy of Sciences of the United States of America. 109: 3065-70. PMID 22315421 DOI: 10.1073/pnas.1121491109  1
2012 Wivagg CN, Hung DT. Resuscitation-promoting factors are required for β-lactam tolerance and the permeability barrier in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 56: 1591-4. PMID 22155826 DOI: 10.1128/AAC.06027-11  1
2012 Liu X, Bolla K, Ashforth EJ, Zhuo Y, Gao H, Huang P, Stanley SA, Hung DT, Zhang L. Systematics-guided bioprospecting for bioactive microbial natural products. Antonie Van Leeuwenhoek. 101: 55-66. PMID 22086462 DOI: 10.1007/s10482-011-9671-1  1
2011 Chand NS, Hung DT. The two-component sensor kinase KinB acts as a non-canonical switch between acute and chronic infection. Virulence. 2: 553-8. PMID 21971182 DOI: 10.4161/viru.2.6.17987  1
2011 Chand NS, Lee JS, Clatworthy AE, Golas AJ, Smith RS, Hung DT. The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection. Journal of Bacteriology. 193: 2989-99. PMID 21515773 DOI: 10.1128/JB.01546-10  1
2011 Gomez JE, Clatworthy A, Hung DT. Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches. Critical Reviews in Biochemistry and Molecular Biology. 46: 41-66. PMID 21250782 DOI: 10.3109/10409238.2010.538663  1
2010 Kaufmann BB, Hung DT. The fast track to multidrug resistance. Molecular Cell. 37: 297-8. PMID 20159549 DOI: 10.1016/j.molcel.2010.01.027  1
2009 Stanley SA, Hung DT. Toward a systems-level analysis of infection biology: a new method for conducting genetic screens in human cells. Science Translational Medicine. 1: 11ps13. PMID 20371455 DOI: 10.1126/scitranslmed.3000550  1
2009 Hett EC, Hung DT. Targeting multiple biofilm pathways. Chemistry & Biology. 16: 1216-8. PMID 20064430 DOI: 10.1016/j.chembiol.2009.12.003  1
2009 Stanley SA, Hung DT. Chemical tools for dissecting bacterial physiology and virulence. Biochemistry. 48: 8776-86. PMID 19653697 DOI: 10.1021/bi9009083  1
2009 Barczak AK, Hung DT. Productive steps toward an antimicrobial targeting virulence. Current Opinion in Microbiology. 12: 490-6. PMID 19631578 DOI: 10.1016/j.mib.2009.06.012  1
2009 Clatworthy AE, Lee JS, Leibman M, Kostun Z, Davidson AJ, Hung DT. Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants. Infection and Immunity. 77: 1293-303. PMID 19168742 DOI: 10.1128/IAI.01181-08  1
2009 Nusbaum C, Ohsumi TK, Gomez J, Aquadro J, Victor TC, Warren RM, Hung DT, Birren BW, Lander ES, Jaffe DB. Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing. Nature Methods. 6: 67-9. PMID 19079253 DOI: 10.1038/nmeth.1286  1
2007 Clatworthy AE, Pierson E, Hung DT. Targeting virulence: A new paradigm for antimicrobial therapy Nature Chemical Biology. 3: 541-548. PMID 17710100 DOI: 10.1038/nchembio.2007.24  1
2007 Shakhnovich EA, Hung DT, Pierson E, Lee K, Mekalanos JJ. Virstatin inhibits dimerization of the transcriptional activator ToxT Proceedings of the National Academy of Sciences of the United States of America. 104: 2372-2377. PMID 17283330 DOI: 10.1073/pnas.0611643104  1
2006 Hung DT, Rubin EJ. Chemical biology and bacteria: not simply a matter of life or death. Current Opinion in Chemical Biology. 10: 321-6. PMID 16814591 DOI: 10.1016/j.cbpa.2006.06.016  1
2006 Hung DT, Zhu J, Sturtevant D, Mekalanos JJ. Bile acids stimulate biofilm formation in Vibrio cholerae. Molecular Microbiology. 59: 193-201. PMID 16359328 DOI: 10.1111/j.1365-2958.2005.04846.x  1
2005 Hung DT, Shakhnovich EA, Pierson E, Mekalanos JJ. Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science (New York, N.Y.). 310: 670-4. PMID 16223984 DOI: 10.1126/science.1116739  1
2005 Hung DT, Mekalanos JJ. Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner. Proceedings of the National Academy of Sciences of the United States of America. 102: 3028-33. PMID 15699331 DOI: 10.1073/pnas.0409559102  1
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