Alan N. Engelman - Publications

Biology: Medical Sciences, Division of Harvard University, Cambridge, MA, United States 
Virology Biology, Biochemistry, Microbiology Biology

104 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Xu C, Fischer DK, Rankovic S, Li W, Dick RA, Runge B, Zadorozhnyi R, Ahn J, Aiken C, Polenova T, Engelman AN, Ambrose Z, Rousso I, Perilla JR. Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis. Plos Biology. 18: e3001015. PMID 33332391 DOI: 10.1371/journal.pbio.3001015  0.6
2020 Francis AC, Marin M, Singh PK, Achuthan V, Prellberg MJ, Palermino-Rowland K, Lan S, Tedbury PR, Sarafianos SG, Engelman AN, Melikyan GB. Publisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains. Nature Communications. 11: 6165. PMID 33244008 DOI: 10.1038/s41467-020-20152-w  0.6
2020 Eschbach JE, Elliott JL, Li W, Zadrozny KK, Davis K, Mohammed SJ, Lawson DQ, Pornillos O, Engelman AN, Kutluay SB. Capsid lattice destabilization leads to premature loss of the viral genome and integrase enzyme during HIV-1 infection. Journal of Virology. PMID 33115869 DOI: 10.1128/JVI.00984-20  0.6
2020 Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, et al. Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science (New York, N.Y.). 370: 360-364. PMID 33060363 DOI: 10.1126/science.abb4808  1
2020 Li W, Singh PK, Sowd GA, Bedwell GJ, Jang S, Achuthan V, Oleru AV, Wong D, Fadel HJ, Lee K, KewalRamani VN, Poeschla EM, Herschhorn A, Engelman AN. CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration. Mbio. 11. PMID 32994325 DOI: 10.1128/mBio.02254-20  1
2020 Elliott JL, Eschbach JE, Koneru PC, Li W, Puray Chavez M, Townsend D, Lawson DQ, Engelman AN, Kvaratskhelia M, Kutluay SB. Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis. Elife. 9. PMID 32960169 DOI: 10.7554/Elife.54311  0.6
2020 Jiang C, Lian X, Gao C, Sun X, Einkauf KB, Chevalier JM, Chen SMY, Hua S, Rhee B, Chang K, Blackmer JE, Osborn M, Peluso MJ, Hoh R, Somsouk M, ... ... Engelman AN, et al. Distinct viral reservoirs in individuals with spontaneous control of HIV-1. Nature. PMID 32848246 DOI: 10.1038/S41586-020-2651-8  1
2020 Ni T, Gerard S, Zhao G, Dent K, Ning J, Zhou J, Shi J, Anderson-Daniels J, Li W, Jang S, Engelman AN, Aiken C, Zhang P. Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A. Nature Structural & Molecular Biology. PMID 32747784 DOI: 10.1038/S41594-020-0467-8  1
2020 Francis AC, Marin M, Singh PK, Achuthan V, Prellberg MJ, Palermino-Rowland K, Lan S, Tedbury PR, Sarafianos SG, Engelman AN, Melikyan GB. HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains. Nature Communications. 11: 3505. PMID 32665593 DOI: 10.1038/s41467-020-17256-8  0.6
2020 Li M, Chen X, Wang H, Jurado KA, Engelman AN, Craigie R. A peptide derived from lens epithelium-derived growth factor stimulates HIV-1 DNA integration and facilitates intasome structural studies. Journal of Molecular Biology. PMID 32061936 DOI: 10.1016/j.jmb.2020.01.040  1
2020 Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P. Structural basis of second-generation HIV integrase inhibitor action and viral resistance. Science (New York, N.Y.). PMID 32001525 DOI: 10.1126/Science.Aay4919  0.6
2019 Anderson-Daniels J, Singh PK, Sowd GA, Li W, Engelman AN, Aiken C. Dominant negative MA-CA fusion protein is incorporated into HIV-1 cores and inhibits nuclear entry of viral preintegration complexes. Journal of Virology. PMID 31413124 DOI: 10.1128/Jvi.01118-19  1
2019 Jang S, Cook NJ, Pye VE, Bedwell GJ, Dudek AM, Singh PK, Cherepanov P, Engelman AN. Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6. Nucleic Acids Research. PMID 30916345 DOI: 10.1093/nar/gkz206  0.6
2018 Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN. Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration. Cell Host & Microbe. PMID 30173955 DOI: 10.1016/j.chom.2018.08.002  1
2018 Engelman AN, Singh PK. Cellular and molecular mechanisms of HIV-1 integration targeting. Cellular and Molecular Life Sciences : Cmls. 75: 2491-2507. PMID 29417178 DOI: 10.1007/s00018-018-2772-5  0.6
2018 Zhu Y, Wang X, Forouzmand E, Jeong J, Qiao F, Sowd GA, Engelman AN, Xie X, Hertel KJ, Shi Y. Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation. Molecular Cell. 69: 62-74.e4. PMID 29276085 DOI: 10.1016/J.Molcel.2017.11.031  1
2017 Sugimura R, Jha DK, Han A, Soria-Valles C, da Rocha EL, Lu YF, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, Wong I, Sousa P, Zhu TN, Ditadi A, Keller G, ... Engelman AN, et al. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature. 545: 432-438. PMID 28514439 DOI: 10.1038/nature22370  1
2017 Lesbats P, Serrao E, Maskell DP, Pye VE, O'Reilly N, Lindemann D, Engelman AN, Cherepanov P. Structural basis for spumavirus GAG tethering to chromatin. Proceedings of the National Academy of Sciences of the United States of America. 114: 5509-5514. PMID 28490494 DOI: 10.1073/pnas.1621159114  1
2017 Wang W, Zhou J, Halambage UD, Jurado KA, Jamin AV, Wang Y, Engelman AN, Aiken C. Inhibition of HIV-1 Maturation via Small-Molecule Targeting of the Amino-Terminal Domain in the Viral Capsid Protein. Journal of Virology. 91. PMID 28202766 DOI: 10.1128/Jvi.02155-16  1
2017 Ballandras-Colas A, Maskell DP, Serrao E, Locke J, Swuec P, Jónsson SR, Kotecha A, Cook NJ, Pye VE, Taylor IA, Andrésdóttir V, Engelman AN, Costa A, Cherepanov P. A supramolecular assembly mediates lentiviral DNA integration. Science (New York, N.Y.). 355: 93-95. PMID 28059770 DOI: 10.1126/science.aah7002  1
2016 Lu YF, Cahan P, Ross S, Sahalie J, Sousa PM, Hadland BK, Cai W, Serrao E, Engelman AN, Bernstein ID, Daley GQ. Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity. Cell Reports. 17: 3178-3192. PMID 28009288 DOI: 10.1016/J.Celrep.2016.11.077  1
2016 Zurnic I, Hütter S, Rzeha U, Helbig R, Stanke N, Reh J, Müllers E, Hamann MV, Kern T, Gerresheim GK, Lindel F, Serrao E, Lesbats P, Engelman AN, Cherepanov P, et al. Correction: Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration. Plos Pathogens. 12: e1005956. PMID 27723818 DOI: 10.1371/journal.ppat.1005956  1
2016 Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. The Journal of Biological Chemistry. 291: 23569-23577. PMID 27645997 DOI: 10.1074/jbc.M116.753384  1
2016 Zurnic I, Hütter S, Rzeha U, Stanke N, Reh J, Müllers E, Hamann MV, Kern T, Gerresheim GK, Lindel F, Serrao E, Lesbats P, Engelman AN, Cherepanov P, Lindemann D. Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration. Plos Pathogens. 12: e1005860. PMID 27579920 DOI: 10.1371/journal.ppat.1005860  1
2016 Zerbato JM, Serrao E, Lenzi G, Kim B, Ambrose Z, Watkins SC, Engelman AN, Sluis-Cremer N. Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro. Journal of Virology. 90: 8059-73. PMID 27356901 DOI: 10.1128/JVI.00553-16  1
2016 Saito A, Henning MS, Serrao E, Dubose BN, Teng S, Huang J, Li X, Saito N, Roy SP, Siddiqui MA, Ahn J, Tsuji M, Hatziioannou T, Engelman AN, Yamashita M. Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage In Vivo. Journal of Virology. 90: 6918-6935. PMID 27307565 DOI: 10.1128/JVI.00019-16  1
2016 Saito A, Ferhadian D, Sowd GA, Serrao E, Shi J, Halambage UD, Teng S, Soto J, Siddiqui MA, Engelman AN, Aiken C, Yamashita M. Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74. Journal of Virology. 90: 5808-5823. PMID 27076642 DOI: 10.1128/Jvi.03116-15  1
2016 Serrao E, Cherepanov P, Engelman AN. Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites. Journal of Visualized Experiments : Jove. PMID 27023428 DOI: 10.3791/53840  1
2016 Rasheedi S, Shun MC, Serrao E, Sowd GA, Qian J, Hao C, Dasgupta T, Engelman AN, Skowronski J. The Cleavage and Polyadenylation Specificity Factor 6 (CPSF6) Subunit of the Capsid-recruited Pre-messenger RNA Cleavage Factor I (CFIm) Complex Mediates HIV-1 Integration into Genes. The Journal of Biological Chemistry. 291: 11809-19. PMID 26994143 DOI: 10.1074/jbc.M116.721647  1
2016 Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M. The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency. Acs Chemical Biology. 11: 1313-21. PMID 26910179 DOI: 10.1021/Acschembio.6B00167  1
2016 Sowd GA, Serrao E, Wang H, Wang W, Fadel HJ, Poeschla EM, Engelman AN. A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin. Proceedings of the National Academy of Sciences of the United States of America. 113: E1054-63. PMID 26858452 DOI: 10.1073/Pnas.1524213113  1
2016 Serrao E, Engelman AN. Sites of retroviral DNA integration: From basic research to clinical applications. Critical Reviews in Biochemistry and Molecular Biology. 51: 26-42. PMID 26508664 DOI: 10.3109/10409238.2015.1102859  1
2016 Ballandras-Colas A, Brown M, Cook NJ, Dewdney TG, Demeler B, Cherepanov P, Lyumkis D, Engelman AN. Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function Nature. 530: 358-361. DOI: 10.1038/nature16955  1
2015 Wang H, Shun MC, Dickson AK, Engelman AN. Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice. Plos One. 10: e0137797. PMID 26367869 DOI: 10.1371/journal.pone.0137797  1
2015 Maskell DP, Renault L, Serrao E, Lesbats P, Matadeen R, Hare S, Lindemann D, Engelman AN, Costa A, Cherepanov P. Structural basis for retroviral integration into nucleosomes. Nature. 523: 366-9. PMID 26061770 DOI: 10.1038/nature14495  1
2015 Serrao E, Ballandras-Colas A, Cherepanov P, Maertens GN, Engelman AN. Key determinants of target DNA recognition by retroviral intasomes. Retrovirology. 12: 39. PMID 25924943 DOI: 10.1186/s12977-015-0167-3  1
2014 Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology. 11: 100. PMID 25421939 DOI: 10.1186/s12977-014-0100-1  1
2014 Wang H, Shun MC, Li X, Di Nunzio F, Hare S, Cherepanov P, Engelman A. Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses. Molecular Therapy. Methods & Clinical Development. 1. PMID 25383358 DOI: 10.1038/mtm.2013.2  1
2014 Matreyek KA, Wang W, Serrao E, Singh PK, Levin HL, Engelman A. Host and viral determinants for MxB restriction of HIV-1 infection. Retrovirology. 11: 90. PMID 25348155 DOI: 10.1186/s12977-014-0090-z  1
2014 Fribourgh JL, Nguyen HC, Matreyek KA, Alvarez FJD, Summers BJ, Dewdney TG, Aiken C, Zhang P, Engelman A, Xiong Y. Structural insight into HIV-1 restriction by MxB. Cell Host & Microbe. 16: 627-638. PMID 25312384 DOI: 10.1016/J.Chom.2014.09.021  0.6
2014 Kvaratskhelia M, Sharma A, Larue RC, Serrao E, Engelman A. Molecular mechanisms of retroviral integration site selection. Nucleic Acids Research. 42: 10209-25. PMID 25147212 DOI: 10.1093/nar/gku769  1
2014 Serrao E, Krishnan L, Shun MC, Li X, Cherepanov P, Engelman A, Maertens GN. Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding. Nucleic Acids Research. 42: 5164-76. PMID 24520116 DOI: 10.1093/nar/gku136  1
2014 Maertens GN, Cook NJ, Wang W, Hare S, Gupta SS, Öztop I, Lee K, Pye VE, Cosnefroy O, Snijders AP, KewalRamani VN, Fassati A, Engelman A, Cherepanov P. Structural basis for nuclear import of splicing factors by human Transportin 3. Proceedings of the National Academy of Sciences of the United States of America. 111: 2728-33. PMID 24449914 DOI: 10.1073/pnas.1320755111  1
2013 Matreyek KA, Yücel SS, Li X, Engelman A. Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity. Plos Pathogens. 9: e1003693. PMID 24130490 DOI: 10.1371/journal.ppat.1003693  0.56
2013 Ballandras-Colas A, Naraharisetty H, Li X, Serrao E, Engelman A. Biochemical characterization of novel retroviral integrase proteins. Plos One. 8: e76638. PMID 24124581 DOI: 10.1371/journal.pone.0076638  1
2013 Matreyek KA, Engelman A. Viral and cellular requirements for the nuclear entry of retroviral preintegration nucleoprotein complexes. Viruses. 5: 2483-511. PMID 24103892 DOI: 10.3390/v5102483  0.56
2013 Jurado KA, Wang H, Slaughter A, Feng L, Kessl JJ, Koh Y, Wang W, Ballandras-Colas A, Patel PA, Fuchs JR, Kvaratskhelia M, Engelman A. Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation. Proceedings of the National Academy of Sciences of the United States of America. 110: 8690-5. PMID 23610442 DOI: 10.1073/Pnas.1300703110  1
2013 Koh Y, Wu X, Ferris AL, Matreyek KA, Smith SJ, Lee K, KewalRamani VN, Hughes SH, Engelman A. Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration. Journal of Virology. 87: 648-58. PMID 23097450 DOI: 10.1128/JVI.01148-12  0.56
2013 Shah VB, Shi J, Hout DR, Oztop I, Krishnan L, Ahn J, Shotwell MS, Engelman A, Aiken C. The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating. Journal of Virology. 87: 422-32. PMID 23097435 DOI: 10.1128/Jvi.07177-11  1
2012 Wang H, Jurado KA, Wu X, Shun MC, Li X, Ferris AL, Smith SJ, Patel PA, Fuchs JR, Cherepanov P, Kvaratskhelia M, Hughes SH, Engelman A. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Research. 40: 11518-30. PMID 23042676 DOI: 10.1093/nar/gks913  1
2012 Matreyek KA, Oztop I, Freed EO, Engelman A. Viral latency and potential eradication of HIV-1. Expert Review of Anti-Infective Therapy. 10: 855-7. PMID 23030323 DOI: 10.1586/eri.12.68  0.56
2012 Ambrose Z, Lee K, Ndjomou J, Xu H, Oztop I, Matous J, Takemura T, Unutmaz D, Engelman A, Hughes SH, KewalRamani VN. Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection. Journal of Virology. 86: 4708-14. PMID 22301145 DOI: 10.1128/Jvi.05887-11  0.56
2012 Li X, Koh Y, Engelman A. Correlation of recombinant integrase activity and functional preintegration complex formation during acute infection by replication-defective integrase mutant human immunodeficiency virus. Journal of Virology. 86: 3861-79. PMID 22278243 DOI: 10.1128/JVI.06386-11  0.48
2011 Matreyek KA, Engelman A. The requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid. Journal of Virology. 85: 7818-27. PMID 21593146 DOI: 10.1128/JVI.00325-11  0.56
2011 Koh Y, Matreyek KA, Engelman A. Differential sensitivities of retroviruses to integrase strand transfer inhibitors. Journal of Virology. 85: 3677-82. PMID 21270168 DOI: 10.1128/JVI.02541-10  0.56
2011 Li X, Krishnan L, Cherepanov P, Engelman A. Structural biology of retroviral DNA integration. Virology. 411: 194-205. PMID 21216426 DOI: 10.1016/j.virol.2010.12.008  0.48
2011 Engelman A. Pleiotropic Nature of HIV-1 Integrase Mutations Hiv-1 Integrase: Mechanism and Inhibitor Design. 67-81. DOI: 10.1002/9781118015377.ch6  1
2011 Hare S, Cherepanov P, Engelman A. Structural aspects of Lentiviral Integrase-LEDGF Interaction Hiv-1 Integrase: Mechanism and Inhibitor Design. 131-140. DOI: 10.1002/9781118015377.ch10  1
2010 Krishnan L, Li X, Naraharisetty HL, Hare S, Cherepanov P, Engelman A. Structure-based modeling of the functional HIV-1 intasome and its inhibition. Proceedings of the National Academy of Sciences of the United States of America. 107: 15910-5. PMID 20733078 DOI: 10.1073/pnas.1002346107  0.48
2010 Lee K, Ambrose Z, Martin TD, Oztop I, Mulky A, Julias JG, Vandegraaff N, Baumann JG, Wang R, Yuen W, Takemura T, Shelton K, Taniuchi I, Li Y, Sodroski J, ... ... Engelman A, et al. Flexible use of nuclear import pathways by HIV-1. Cell Host & Microbe. 7: 221-33. PMID 20227665 DOI: 10.1016/J.Chom.2010.02.007  0.56
2010 Ferris AL, Wu X, Hughes CM, Stewart C, Smith SJ, Milne TA, Wang GG, Shun MC, Allis CD, Engelman A, Hughes SH. Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration. Proceedings of the National Academy of Sciences of the United States of America. 107: 3135-40. PMID 20133638 DOI: 10.1073/Pnas.0914142107  1
2010 Krishnan L, Matreyek KA, Oztop I, Lee K, Tipper CH, Li X, Dar MJ, Kewalramani VN, Engelman A. The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase. Journal of Virology. 84: 397-406. PMID 19846519 DOI: 10.1128/JVI.01899-09  0.56
2009 Dar MJ, Monel B, Krishnan L, Shun MC, Di Nunzio F, Helland DE, Engelman A. Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase. Retrovirology. 6: 94. PMID 19840380 DOI: 10.1186/1742-4690-6-94  1
2009 Engelman A, Oztop I, Vandegraaff N, Raghavendra NK. Quantitative analysis of HIV-1 preintegration complexes. Methods (San Diego, Calif.). 47: 283-90. PMID 19233280 DOI: 10.1016/j.ymeth.2009.02.005  0.56
2009 Hare S, Shun MC, Gupta SS, Valkov E, Engelman A, Cherepanov P. A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75. Plos Pathogens. 5: e1000259. PMID 19132083 DOI: 10.1371/journal.ppat.1000259  1
2008 Shun MC, Botbol Y, Li X, Di Nunzio F, Daigle JE, Yan N, Lieberman J, Lavigne M, Engelman A. Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity. Journal of Virology. 82: 11555-67. PMID 18799576 DOI: 10.1128/JVI.01561-08  1
2008 Botbol Y, Raghavendra NK, Rahman S, Engelman A, Lavigne M. Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro. Nucleic Acids Research. 36: 1237-46. PMID 18174227 DOI: 10.1093/nar/gkm1127  0.4
2007 Shun MC, Raghavendra NK, Vandegraaff N, Daigle JE, Hughes S, Kellam P, Cherepanov P, Engelman A. LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration. Genes & Development. 21: 1767-78. PMID 17639082 DOI: 10.1101/gad.1565107  1
2007 Mbisa JL, Barr R, Thomas JA, Vandegraaff N, Dorweiler IJ, Svarovskaia ES, Brown WL, Mansky LM, Gorelick RJ, Harris RS, Engelman A, Pathak VK. Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration. Journal of Virology. 81: 7099-110. PMID 17428871 DOI: 10.1128/Jvi.00272-07  0.4
2007 Vandegraaff N, Engelman A. Molecular mechanisms of HIV integration and therapeutic intervention. Expert Reviews in Molecular Medicine. 9: 1-19. PMID 17320002 DOI: 10.1017/S1462399407000257  0.4
2007 Raghavendra NK, Engelman A. LEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: implications for the mechanism of viral cDNA integration. Virology. 360: 1-5. PMID 17258258 DOI: 10.1016/j.virol.2006.12.022  0.4
2007 Shun MC, Daigle JE, Vandegraaff N, Engelman A. Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin protein. Journal of Virology. 81: 166-72. PMID 17035312 DOI: 10.1128/JVI.01953-06  1
2007 Rahman S, Lu R, Vandegraaff N, Cherepanov P, Engelman A. Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness. Virology. 357: 79-90. PMID 16959283 DOI: 10.1016/j.virol.2006.08.011  0.4
2006 Anderson JL, Campbell EM, Wu X, Vandegraaff N, Engelman A, Hope TJ. Proteasome inhibition reveals that a functional preintegration complex intermediate can be generated during restriction by diverse TRIM5 proteins. Journal of Virology. 80: 9754-60. PMID 16973579 DOI: 10.1128/JVI.01052-06  0.4
2006 Diaz-Griffero F, Vandegraaff N, Li Y, McGee-Estrada K, Stremlau M, Welikala S, Si Z, Engelman A, Sodroski J. Requirements for capsid-binding and an effector function in TRIMCyp-mediated restriction of HIV-1. Virology. 351: 404-19. PMID 16650449 DOI: 10.1016/J.Virol.2006.03.023  0.4
2006 Si Z, Vandegraaff N, O'huigin C, Song B, Yuan W, Xu C, Perron M, Li X, Marasco WA, Engelman A, Dean M, Sodroski J. Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection. Proceedings of the National Academy of Sciences of the United States of America. 103: 7454-9. PMID 16648259 DOI: 10.1073/Pnas.0600771103  0.48
2006 Vandegraaff N, Devroe E, Turlure F, Silver PA, Engelman A. Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication. Virology. 346: 415-26. PMID 16337983 DOI: 10.1016/J.Virol.2005.11.022  0.4
2005 Lu R, Vandegraaff N, Cherepanov P, Engelman A. Lys-34, dispensable for integrase catalysis, is required for preintegration complex function and human immunodeficiency virus type 1 replication. Journal of Virology. 79: 12584-91. PMID 16160186 DOI: 10.1128/JVI.79.19.12584-12591.2005  0.4
2003 Engelman A. The roles of cellular factors in retroviral integration Current Topics in Microbiology and Immunology. 281: 209-238. PMID 12932079 DOI: 10.1007/978-3-642-19012-4_6  1
2001 Chen H, Engelman A. Asymmetric processing of human immunodeficiency virus type 1 cDNA in vivo: Implications for functional end coupling during the chemical steps of DNA transposition Molecular and Cellular Biology. 21: 6758-6767. PMID 11564861 DOI: 10.1128/MCB.21.20.6758-6767.2001  1
2001 Nakajima N, Lu R, Engelman A. Human immunodeficiency virus type 1 replication in the absence of integrase-mediated DNA recombination: Definition of permissive and nonpermissive T-cell lines Journal of Virology. 75: 7944-7955. PMID 11483739 DOI: 10.1128/JVI.75.17.7944-7955.2001  1
2000 Harris D, Engelman A. Both the structure and DNA binding function of the barrier-to-autointegration factor contribute to reconstitution of HIV type 1 integration in vitro Journal of Biological Chemistry. 275: 39671-39677. PMID 11005805 DOI: 10.1074/jbc.M002626200  1
2000 Chen H, Engelman A. Characterization of a replication-defective human immunodeficiency virus type 1 att site mutant that is blocked after the 3' processing step of retroviral integration Journal of Virology. 74: 8188-8193. PMID 10933731 DOI: 10.1128/JVI.74.17.8188-8193.2000  1
1999 Brown HE, Chen H, Engelman A. Structure-based mutagenesis of the human immunodeficiency virus type 1 DNA attachment site: effects on integration and cDNA synthesis. Journal of Virology. 73: 9011-20. PMID 10516007 DOI: 10.1128/jvi.73.11.9011-9020.1999  1
1999 Chen H, Wei SQ, Engelman A. Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome Journal of Biological Chemistry. 274: 17358-17364. PMID 10358097 DOI: 10.1074/jbc.274.24.17358  1
1998 Chen H, Engelman A. The barrier-to-autointegration protein is a host factor for HIV type 1 integration Proceedings of the National Academy of Sciences of the United States of America. 95: 15270-15274. PMID 9860958 DOI: 10.1073/pnas.95.26.15270  1
1997 Jenkins TM, Esposito D, Engelman A, Craigie R. Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking. The Embo Journal. 16: 6849-59. PMID 9362498 DOI: 10.1093/emboj/16.22.6849  1
1996 Engelman A. Biochemical characterization of recombinant equine infectious anemia virus integrase Protein Expression and Purification. 8: 299-304. PMID 8936591 DOI: 10.1006/prep.1996.0104  1
1995 Englund G, Theodore TS, Freed EO, Engelman A, Martin MA. Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1 Journal of Virology. 69: 3216-3219. PMID 7707554 DOI: 10.1128/jvi.69.5.3216-3219.1995  1
1995 Engelman A, Craigie R. Efficient magnesium-dependent human immunodeficiency virus type 1 integrase activity Journal of Virology. 69: 5908-5911. PMID 7637039 DOI: 10.1128/jvi.69.9.5908-5911.1995  1
1995 Engelman A, Englund G, Orenstein JM, Martin MA, Craigie R. Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication Journal of Virology. 69: 2729-2736. PMID 7535863 DOI: 10.1128/jvi.69.5.2729-2736.1995  1
1994 Mazumder A, Engelman A, Craigie R, Fesen M, Pommier Y. Intermolecular disintegration and intramolecular strand transfer activities of wild-type and mutant HIV-1 integrase Nucleic Acids Research. 22: 1037-1043. PMID 8152908 DOI: 10.1093/nar/22.6.1037  1
1994 Engelman A, Hickman AB, Craigie R. The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding Journal of Virology. 68: 5911-5917. PMID 8057470 DOI: 10.1128/jvi.68.9.5911-5917.1994  1
1994 Vicenzi E, Dimitrov DS, Engelman A, Migone TS, Purcell DF, Leonard J, Englund G, Martin MA. An integration-defective U5 deletion mutant of human immunodeficiency virus type 1 reverts by eliminating additional long terminal repeat sequences. Journal of Virology. 68: 7879-90. PMID 7966578 DOI: 10.1128/jvi.68.12.7879-7890.1994  1
1994 Engelman A. Most of the avian genome appears available for retroviral DNA integration Bioessays. 16: 797-799. PMID 7840756 DOI: 10.1002/bies.950161105  1
1994 Dyda F, Hickman AB, Jenkins TM, Engelman A, Craigie R, Davies DR. Crystal structure of the catalytic domain of HIV-1 integrase: Similarity to other polynucleotidyl transferases Science. 266: 1981-1986. PMID 7801124 DOI: 10.1126/Science.7801124  1
1993 Bushman FD, Engelman A, Palmer I, Wingfield P, Craigie R. Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding Proceedings of the National Academy of Sciences of the United States of America. 90: 3428-3432. PMID 8386373 DOI: 10.1073/Pnas.90.8.3428  1
1992 Engelman A, Craigie R. Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro Journal of Virology. 66: 6361-6369. PMID 1404595 DOI: 10.1128/jvi.66.11.6361-6369.1992  1
1991 Craigie R, Mizuuchi K, Bushman FD, Engelman A. A rapid in vitro assay for HIV DNA integration. Nucleic Acids Research. 19: 2729-34. PMID 2041748 DOI: 10.1093/Nar/19.10.2729  1
1991 Engelman A, Mizuuchi K, Craigie R. HIV-1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer. Cell. 67: 1211-21. PMID 1760846 DOI: 10.1016/0092-8674(91)90297-C  1
1990 Engelman A, Rosenberg N. bcr/abl and src but not myc and ras replace v-abl in lymphoid transformation Molecular and Cellular Biology. 10: 4365-4369. PMID 2164639 DOI: 10.1128/Mcb.10.8.4365  1
1990 Engelman A, Rosenberg N. Temperature-sensitive mutants of Abelson murine leukemia virus deficient in protein tyrosine kinase activity Journal of Virology. 64: 4242-4251. PMID 1696637 DOI: 10.1128/Jvi.64.9.4242-4251.1990  1
1988 Engelman A, Rosenberg N. The Abelson protein is required for initiation and maintenance for transformation in murine pre-B cells Current Topics in Microbiology and Immunology. 141: 310-315. PMID 3265094 DOI: 10.1007/978-3-642-74006-0_41  1
1987 Engelman A, Rosenberg N. Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis Proceedings of the National Academy of Sciences of the United States of America. 84: 8021-8025. PMID 2825174 DOI: 10.1073/Pnas.84.22.8021  1
Show low-probability matches.