Year |
Citation |
Score |
2020 |
Chung E, Choi Y, Park J, Nah W, Park J, Jung Y, Lee J, Lee H, Park S, Hwang S, Kim S, Lee J, Min D, Jo J, Kang S, ... ... Ruley HE, et al. Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological α-synuclein. Science Advances. 6: eaba1193. PMID 32494688 DOI: 10.1126/Sciadv.Aba1193 |
0.547 |
|
2014 |
Duong T, Kim J, Ruley HE, Jo D. Cell-permeable parkin proteins suppress Parkinson disease-associated phenotypes in cultured cells and animals. Plos One. 9: e102517. PMID 25019626 DOI: 10.1371/Journal.Pone.0102517 |
0.595 |
|
2013 |
Lim J, Duong T, Lee G, Seong BL, El-Rifai W, Ruley HE, Jo D. The effect of intracellular protein delivery on the anti-tumor activity of recombinant human endostatin. Biomaterials. 34: 6261-71. PMID 23714245 DOI: 10.1016/J.Biomaterials.2013.05.011 |
0.641 |
|
2013 |
Lim J, Duong T, Do N, Do P, Kim J, Kim H, El-Rifai W, Ruley HE, Jo D. Antitumor activity of cell-permeable RUNX3 protein in gastric cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 680-90. PMID 23230322 DOI: 10.1158/1078-0432.Ccr-12-2692 |
0.526 |
|
2012 |
Lim J, Kim J, Duong T, Lee G, Kim J, Yoon J, Kim J, Kim H, Ruley HE, El-Rifai W, Jo D. Antitumor activity of cell-permeable p18(INK4c) with enhanced membrane and tissue penetration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1540-9. PMID 22617107 DOI: 10.1038/Mt.2012.102 |
0.622 |
|
2012 |
Lin Q, Liu Y, Moore DJ, Elizer SK, Veach RA, Hawiger J, Ruley HE. Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 188: 2493-7. PMID 22323537 DOI: 10.4049/Jimmunol.1101502 |
0.325 |
|
2012 |
Jo D, Ruley HE, El-Rifai W. Mo1612 Anti-Tumor Activity of Cell-Permeable P18ink4c With Enhanced Membrane and Tissue Penetration Gastroenterology. 142: S-641. DOI: 10.1016/S0016-5085(12)62467-6 |
0.626 |
|
2012 |
Jo D, Ruley HE, El-Rifai W. Mo1611 Traditional African and Western Diets Select Distinct Phylogenetic and Functional Colonic Microbiota Among Different Populations Mo1612 Anti-Tumor Activity of Cell-Permeable P18ink4c With Enhanced Membrane and Tissue Penetration Gastroenterology. 142: S-641. DOI: 10.1016/S0016-5085(12)62466-4 |
0.558 |
|
2012 |
Jo D, Ruley HE, El-Rifai W. Mo1552 Intracellular Delivered RUNx3 Effectively Inhibits Migration and Proliferation of Gastric Cancer Cells Gastroenterology. 142: S-626-S-627. DOI: 10.1016/S0016-5085(12)62407-X |
0.555 |
|
2011 |
Lim J, Jang G, Kang S, Lee G, Nga do TT, Phuong do TL, Kim H, El-Rifai W, Ruley HE, Jo D. Cell-permeable NM23 blocks the maintenance and progression of established pulmonary metastasis. Cancer Research. 71: 7216-25. PMID 21987726 DOI: 10.1158/0008-5472.Can-11-2015 |
0.606 |
|
2010 |
Jeon D, Kim S, Chetana M, Jo D, Ruley HE, Lin SY, Rabah D, Kinet JP, Shin HS. Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC. Nature Neuroscience. 13: 482-8. PMID 20190743 DOI: 10.1038/Nn.2504 |
0.508 |
|
2008 |
Osipovich AB, Jennings JL, Lin Q, Link AJ, Ruley HE. Dyggve-Melchior-Clausen syndrome: chondrodysplasia resulting from defects in intracellular vesicle traffic. Proceedings of the National Academy of Sciences of the United States of America. 105: 16171-6. PMID 18852472 DOI: 10.1073/Pnas.0804259105 |
0.349 |
|
2008 |
Cao S, Carlesso G, Osipovich AB, Llanes J, Lin Q, Hoek KL, Khan WN, Ruley HE. Subunit 1 of the prefoldin chaperone complex is required for lymphocyte development and function. Journal of Immunology (Baltimore, Md. : 1950). 181: 476-84. PMID 18566413 DOI: 10.4049/Jimmunol.181.1.476 |
0.32 |
|
2006 |
Lin Q, Donahue SL, Ruley HE. Genome maintenance and mutagenesis in embryonic stem cells. Cell Cycle (Georgetown, Tex.). 5: 2710-4. PMID 17172854 DOI: 10.4161/Cc.5.23.3517 |
0.341 |
|
2006 |
Lin Q, Donahue SL, Moore-Jarrett T, Cao S, Osipovich AB, Ruley HE. Mutagenesis of diploid mammalian genes by gene entrapment. Nucleic Acids Research. 34: e139. PMID 17062627 DOI: 10.1093/Nar/Gkl728 |
0.456 |
|
2006 |
Donahue SL, Lin Q, Cao S, Ruley HE. Carcinogens induce genome-wide loss of heterozygosity in normal stem cells without persistent chromosomal instability. Proceedings of the National Academy of Sciences of the United States of America. 103: 11642-6. PMID 16868089 DOI: 10.1073/Pnas.0510741103 |
0.355 |
|
2006 |
Rubin DH, Ruley HE. Cellular genetics of host susceptibility and resistance to virus infection. Critical Reviews in Eukaryotic Gene Expression. 16: 155-70. PMID 16749895 DOI: 10.1615/Critreveukargeneexpr.V16.I2.40 |
0.355 |
|
2005 |
Roshon MJ, Ruley HE. Hypomorphic mutation in hnRNP U results in post-implantation lethality. Transgenic Research. 14: 179-92. PMID 16022389 DOI: 10.1007/S11248-004-8147-8 |
0.433 |
|
2005 |
Osipovich AB, Singh A, Ruley HE. Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment. Genome Research. 15: 428-35. PMID 15741512 DOI: 10.1101/Gr.3258105 |
0.453 |
|
2005 |
Scott RE, White-Grindley E, Ruley HE, Chesler EJ, Williams RW. P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA. Journal of Cellular Physiology. 204: 99-105. PMID 15617101 DOI: 10.1002/Jcp.20263 |
0.725 |
|
2004 |
Organ EL, Sheng J, Ruley HE, Rubin DH. Discovery of mammalian genes that participate in virus infection. Bmc Cell Biology. 5: 41. PMID 15522117 DOI: 10.1186/1471-2121-5-41 |
0.341 |
|
2004 |
Lin Q, Jo D, Gebre-Amlak KD, Ruley HE. Enhanced cell-permeant Cre protein for site-specific recombination in cultured cells. Bmc Biotechnology. 4: 25. PMID 15500682 DOI: 10.1186/1472-6750-4-25 |
0.655 |
|
2004 |
Sheng J, Organ EL, Hao C, Wells KS, Ruley HE, Rubin DH. Mutations in the IGF-II pathway that confer resistance to lytic reovirus infection. Bmc Cell Biology. 5: 32. PMID 15333144 DOI: 10.1186/1471-2121-5-32 |
0.327 |
|
2004 |
Osipovich AB, White-Grindley EK, Hicks GG, Roshon MJ, Shaffer C, Moore JH, Ruley HE. Activation of cryptic 3' splice sites within introns of cellular genes following gene entrapment. Nucleic Acids Research. 32: 2912-24. PMID 15155860 DOI: 10.1093/Nar/Gkh604 |
0.734 |
|
2003 |
Cao S, Bendall H, Hicks GG, Nashabi A, Sakano H, Shinkai Y, Gariglio M, Oltz EM, Ruley HE. The high-mobility-group box protein SSRP1/T160 is essential for cell viability in day 3.5 mouse embryos. Molecular and Cellular Biology. 23: 5301-7. PMID 12861016 DOI: 10.1128/Mcb.23.15.5301-5307.2003 |
0.416 |
|
2003 |
Jo D, Lin Q, Nashabi A, Mays DJ, Unutmaz D, Pietenpol JA, Ruley HE. Cell cycle-dependent transduction of cell-permeant Cre recombinase proteins. Journal of Cellular Biochemistry. 89: 674-87. PMID 12858334 DOI: 10.1002/Jcb.10542 |
0.629 |
|
2003 |
Roshon M, DeGregori JV, Ruley HE. Gene trap mutagenesis of hnRNP A2/B1: a cryptic 3' splice site in the neomycin resistance gene allows continued expression of the disrupted cellular gene. Bmc Genomics. 4: 2. PMID 12546712 DOI: 10.1186/1471-2164-4-2 |
0.623 |
|
2002 |
Pawlak MR, Banik-Maiti S, Pietenpol JA, Ruley HE. Protein arginine methyltransferase I: substrate specificity and role in hnRNP assembly. Journal of Cellular Biochemistry. 87: 394-407. PMID 12397599 DOI: 10.1002/Jcb.10307 |
0.732 |
|
2001 |
Jo D, Nashabi A, Doxsee C, Lin Q, Unutmaz D, Chen J, Ruley HE. Epigenetic regulation of gene structure and function with a cell-permeable Cre recombinase. Nature Biotechnology. 19: 929-33. PMID 11581657 DOI: 10.1038/Nbt1001-929 |
0.683 |
|
2001 |
Ruley HE. Functional genomics of the murine immune system. Immunologic Research. 23: 289-99. PMID 11444394 DOI: 10.1385/Ir:23:2-3:289 |
0.397 |
|
2000 |
Peck SR, Ruley HE. Ly108: a new member of the mouse CD2 family of cell surface proteins. Immunogenetics. 52: 63-72. PMID 11132158 DOI: 10.1007/S002510000252 |
0.351 |
|
2000 |
Pawlak MR, Scherer CA, Chen J, Roshon MJ, Ruley HE. Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable. Molecular and Cellular Biology. 20: 4859-69. PMID 10848611 DOI: 10.1128/Mcb.20.13.4859-4869.2000 |
0.725 |
|
2000 |
Williamson DJ, Banik-Maiti S, DeGregori J, Ruley HE. hnRNP C is required for postimplantation mouse development but Is dispensable for cell viability. Molecular and Cellular Biology. 20: 4094-105. PMID 10805751 DOI: 10.1128/Mcb.20.11.4094-4105.2000 |
0.708 |
|
1998 |
Chen J, Ruley HE. An enhancer element in the EphA2 (Eck) gene sufficient for rhombomere-specific expression is activated by HOXA1 and HOXB1 homeobox proteins. The Journal of Biological Chemistry. 273: 24670-5. PMID 9733765 DOI: 10.1074/jbc.273.38.24670 |
0.316 |
|
1997 |
Hicks GG, Shi EG, Li XM, Li CH, Pawlak M, Ruley HE. Functional genomics in mice by tagged sequence mutagenesis. Nature Genetics. 16: 338-44. PMID 9241269 DOI: 10.1038/ng0897-338 |
0.34 |
|
1996 |
Scherer CA, Chen J, Nachabeh A, Hopkins N, Ruley HE. Transcriptional specificity of the pluripotent embryonic stem cell. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 7: 1393-401. PMID 8891343 |
0.323 |
|
1995 |
Hicks GG, Shi EG, Chen J, Roshon M, Williamson D, Scherer C, Ruley HE. Retrovirus gene traps. Methods in Enzymology. 254: 263-75. PMID 8531691 DOI: 10.1016/0076-6879(95)54019-9 |
0.447 |
|
1994 |
DeGregori J, Russ A, Von Melchner H, Rayburn H, Priyaranjan P, Jenkins NA, Copeland NG, Ruley HE. A murine homolog of the yeast RNA1 gene is required for postimplantation development Genes and Development. 8: 265-276. PMID 8314081 DOI: 10.1101/Gad.8.3.265 |
0.6 |
|
1993 |
Chang W, Hubbard SC, Friedel C, Ruley HE. Enrichment of insertional mutants following retrovirus gene trap selection. Virology. 193: 737-47. PMID 8460482 DOI: 10.1006/viro.1993.1182 |
0.313 |
|
1993 |
Lowe SW, Ruley HE, Jacks T, Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 74: 957-67. PMID 8402885 DOI: 10.1016/0092-8674(93)90719-7 |
0.326 |
|
1992 |
Reddy S, Rayburn H, von Melchner H, Ruley HE. Fluorescence-activated sorting of totipotent embryonic stem cells expressing developmentally regulated lacZ fusion genes. Proceedings of the National Academy of Sciences of the United States of America. 89: 6721-5. PMID 1495960 DOI: 10.1073/pnas.89.15.6721 |
0.343 |
|
1992 |
von Melchner H, DeGregori JV, Rayburn H, Reddy S, Friedel C, Ruley HE. Selective disruption of genes expressed in totipotent embryonal stem cells. Genes & Development. 6: 919-27. PMID 1317320 DOI: 10.1101/Gad.6.6.919 |
0.611 |
|
1991 |
Ragozzino MM, Kuo A, DeGregori J, Kohl N, Ruley HE. Mechanisms of oncogene cooperation: activation and inactivation of a growth antagonist. Environmental Health Perspectives. 93: 97-103. PMID 1837777 DOI: 10.1289/Ehp.919397 |
0.541 |
|
1991 |
Reddy S, DeGregori JV, von Melchner H, Ruley HE. Retrovirus promoter-trap vector to induce lacZ gene fusions in mammalian cells. Journal of Virology. 65: 1507-15. PMID 1704929 DOI: 10.1128/Jvi.65.3.1507-1515.1991 |
0.589 |
|
1990 |
von Melchner H, Reddy S, Ruley HE. Isolation of cellular promoters by using a retrovirus promoter trap. Proceedings of the National Academy of Sciences of the United States of America. 87: 3733-7. PMID 2339116 DOI: 10.1073/pnas.87.10.3733 |
0.361 |
|
1990 |
von Melchner H, Ruley HE. Retroviruses as genetic tools to isolate transcriptionally active chromosomal regions. Environmental Health Perspectives. 88: 141-8. PMID 2272309 |
0.324 |
|
1989 |
von Melchner H, Ruley HE. Identification of cellular promoters by using a retrovirus promoter trap. Journal of Virology. 63: 3227-33. PMID 2545900 |
0.363 |
|
1988 |
Ruley HE, Chaudry F, Read M, Lania L, Fried M. The structure and function of the integrated polyoma virus DNA in 82-rat and 53-rat transformed cells. The Journal of General Virology. 69: 197-207. PMID 2826666 DOI: 10.1099/0022-1317-69-1-197 |
0.508 |
|
1983 |
Ruley HE, Fried M. Clustered illegitimate recombination events in mammalian cells involving very short sequence homologies. Nature. 304: 181-4. PMID 6306477 DOI: 10.1038/304181a0 |
0.521 |
|
1983 |
Ruley HE, Fried M. Sequence repeats in a polyoma virus DNA region important for gene expression. Journal of Virology. 47: 233-7. PMID 6306275 DOI: 10.1128/JVI.47.1.233-237.1983 |
0.518 |
|
1982 |
Hayday A, Ruley HE, Fried M. Structural and biological analysis of integrated polyoma virus DNA and its adjacent host sequences cloned from transformed rat cells. Journal of Virology. 44: 67-77. PMID 6292505 |
0.623 |
|
1982 |
Ruley HE, Lania L, Chaudry F, Fried M. Use of a cellular polyadenylation signal by viral transcripts in polyoma virus transformed cells. Nucleic Acids Research. 10: 4515-24. PMID 6290990 DOI: 10.1093/Nar/10.15.4515 |
0.576 |
|
Low-probability matches (unlikely to be authored by this person) |
1986 |
Cook JL, Walker TA, Lewis AM, Ruley HE, Graham FL, Pilder SH. Expression of the adenovirus E1A oncogene during cell transformation is sufficient to induce susceptibility to lysis by host inflammatory cells. Proceedings of the National Academy of Sciences of the United States of America. 83: 6965-9. PMID 2944117 DOI: 10.1073/Pnas.83.18.6965 |
0.297 |
|
1994 |
Hubbard SC, Walls L, Ruley HE, Muchmore EA. Generation of Chinese hamster ovary cell glycosylation mutants by retroviral insertional mutagenesis. Integration into a discrete locus generates mutants expressing high levels of N-glycolylneuraminic acid. The Journal of Biological Chemistry. 269: 3717-24. PMID 8106417 |
0.295 |
|
1996 |
Martin WD, Hicks GG, Mendiratta SK, Leva HI, Ruley HE, Van Kaer L. H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell. 84: 543-50. PMID 8598041 DOI: 10.1016/S0092-8674(00)81030-2 |
0.295 |
|
1996 |
Chen J, Nachabah A, Scherer C, Ganju P, Reith A, Bronson R, Ruley HE. Germ-line inactivation of the murine Eck receptor tyrosine kinase by gene trap retroviral insertion. Oncogene. 12: 979-88. PMID 8649815 |
0.295 |
|
2000 |
Hicks GG, Singh N, Nashabi A, Mai S, Bozek G, Klewes L, Arapovic D, White EK, Koury MJ, Oltz EM, Van Kaer L, Ruley HE. Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death. Nature Genetics. 24: 175-9. PMID 10655065 DOI: 10.1038/72842 |
0.289 |
|
2001 |
White EK, Moore-Jarrett T, Ruley HE. PUM2, a novel murine puf protein, and its consensus RNA-binding site. Rna (New York, N.Y.). 7: 1855-66. PMID 11780640 |
0.288 |
|
1991 |
Ravid K, Beeler DL, Rabin MS, Ruley HE, Rosenberg RD. Selective targeting of gene products with the megakaryocyte platelet factor 4 promoter. Proceedings of the National Academy of Sciences of the United States of America. 88: 1521-5. PMID 1899930 DOI: 10.1073/Pnas.88.4.1521 |
0.283 |
|
1982 |
Ruley HE, Lania L, Chaudry F, Fried M. Use of a cellular potyadenylation signal by viral transcripts in polyoma virus transformed cells Nucleic Acids Research. 10: 4515-4524. DOI: 10.1093/nar/10.15.4515 |
0.278 |
|
1987 |
Frisch SM, Ruley HE. Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone. The Journal of Biological Chemistry. 262: 16300-4. PMID 2824488 |
0.271 |
|
1986 |
Zerler B, Moran B, Maruyama K, Moomaw J, Grodzicker T, Ruley HE. Adenovirus E1A coding sequences that enable ras and pmt oncogenes to transform cultured primary cells. Molecular and Cellular Biology. 6: 887-99. PMID 3022137 |
0.269 |
|
1998 |
Kelley LL, Hicks GG, Hsieh FF, Prasher JM, Green WF, Miller MD, Eide EJ, Ruley HE. Endogenous p53 regulation and function in early stage Friend virus-induced tumor progression differs from that following DNA damage. Oncogene. 17: 1119-30. PMID 9764822 DOI: 10.1038/sj.onc.1202037 |
0.264 |
|
1983 |
Ruley HE. Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. Nature. 304: 602-6. PMID 6308473 DOI: 10.1038/304602a0 |
0.248 |
|
1994 |
Kelley LL, Green WF, Hicks GG, Bondurant MC, Koury MJ, Ruley HE. Apoptosis in erythroid progenitors deprived of erythropoietin occurs during the G1 and S phases of the cell cycle without growth arrest or stabilization of wild-type p53. Molecular and Cellular Biology. 14: 4183-92. PMID 8196656 |
0.236 |
|
1990 |
Reddy S, Ozgur K, Lu M, Chang W, Mohan SR, Kumar CC, Ruley HE. Structure of the human smooth muscle alpha-actin gene. Analysis of a cDNA and 5' upstream region. The Journal of Biological Chemistry. 265: 1683-7. PMID 2295650 |
0.224 |
|
1994 |
Lowe SW, Jacks T, Housman DE, Ruley HE. Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 2026-30. PMID 8134344 DOI: 10.1073/Pnas.91.6.2026 |
0.223 |
|
1990 |
Ruley HE. Transforming collaborations between ras and nuclear oncogenes. Cancer Cells (Cold Spring Harbor, N.Y. : 1989). 2: 258-68. PMID 2223387 |
0.214 |
|
1993 |
Lowe SW, Ruley HE. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis. Genes & Development. 7: 535-45. PMID 8384579 |
0.213 |
|
1987 |
Maruyama K, Schiavi SC, Huse W, Johnson GL, Ruley HE. myc and E1A oncogenes alter the responses of PC12 cells to nerve growth factor and block differentiation. Oncogene. 1: 361-7. PMID 2838784 |
0.202 |
|
1994 |
Lowe SW, Bodis S, McClatchey A, Remington L, Ruley HE, Fisher DE, Housman DE, Jacks T. p53 status and the efficacy of cancer therapy in vivo. Science (New York, N.Y.). 266: 807-10. PMID 7973635 DOI: 10.1126/Science.7973635 |
0.179 |
|
1986 |
Franza BR, Maruyama K, Garrels JI, Ruley HE. In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes. Cell. 44: 409-18. PMID 3510745 DOI: 10.1016/0092-8674(86)90462-9 |
0.178 |
|
1987 |
Kohl NE, Ruley HE. Role of c-myc in the transformation of REF52 cells by viral and cellular oncogenes. Oncogene. 2: 41-8. PMID 2830582 |
0.177 |
|
1988 |
Whyte P, Ruley HE, Harlow E. Two regions of the adenovirus early region 1A proteins are required for transformation. Journal of Virology. 62: 257-65. PMID 2960834 DOI: 10.1128/Jvi.62.1.257-265.1988 |
0.176 |
|
1995 |
Bushel P, Kim JH, Chang W, Catino JJ, Ruley HE, Kumar CC. Two serum response elements mediate transcriptional repression of human smooth muscle alpha-actin promoter in ras-transformed cells. Oncogene. 10: 1361-70. PMID 7731687 |
0.158 |
|
1982 |
Anderson LM, Ruley HE, Bott KF. Isolation of an autonomously replicating DNA fragment from the region of defective bacteriophage PBSX of Bacillus subtilis. Journal of Bacteriology. 150: 1280-6. PMID 6804442 |
0.156 |
|
1988 |
Hirakawa T, Ruley HE. Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene. Proceedings of the National Academy of Sciences of the United States of America. 85: 1519-23. PMID 2830621 |
0.136 |
|
1991 |
Hirakawa T, Maruyama K, Kohl NE, Kodama T, Ruley HE. Massive accumulation of neutral lipids in cells conditionally transformed by an activated H-ras oncogene. Oncogene. 6: 289-95. PMID 2000221 |
0.113 |
|
1994 |
Lowe SW, Bodis S, Bardeesy N, McClatchey A, Remington L, Ruley HE, Fisher DE, Jacks T, Pelletier J, Housman DE. Apoptosis and the prognostic significance of p53 mutation. Cold Spring Harbor Symposia On Quantitative Biology. 59: 419-26. PMID 7587096 |
0.069 |
|
1996 |
Ruley HE. p53 and response to chemotherapy and radiotherapy. Important Advances in Oncology. 37-56. PMID 8791127 |
0.027 |
|
Hide low-probability matches. |