Ilya Frolov - Publications

Affiliations: 
Microbiology University of Alabama, Birmingham, Birmingham, AL, United States 
Area:
Virology Biology

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Lukash T, Agback T, Dominguez F, Shiliaev N, Meshram C, Frolova EI, Agback P, Frolov I. Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein. Journal of Virology. PMID 33055253 DOI: 10.1128/JVI.01672-20  0.76
2020 Meshram CD, Shiliaev N, Frolova EI, Frolov I. Hypervariable Domain of nsP3 of Eastern Equine Encephalitis Virus is a Critical Determinant of Viral Virulence. Journal of Virology. PMID 32581106 DOI: 10.1128/JVI.00617-20  0.76
2019 Meshram CD, Phillips AT, Lukash T, Shiliaev N, Frolova EI, Frolov I. Mutations in Hypervariable Domain of Venezuelan Equine Encephalitis Virus nsP3 Protein Differentially Affect Viral Replication. Journal of Virology. PMID 31694937 DOI: 10.1128/JVI.01841-19  0.76
2019 Agback P, Dominguez F, Pustovalova Y, Lukash T, Shiliaev N, Orekhov VY, Frolov I, Agback T, Frolova EI. Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 protein. Virology. 537: 130-142. PMID 31493651 DOI: 10.1016/j.virol.2019.08.022  0.76
2019 Meshram CD, Lukash T, Philips AT, Akhrymuk I, Frolova EI, Frolov I. Lack of nsP2-specific nuclear functions attenuates chikungunya virus replication both in vitro and in vivo. Virology. 534: 14-24. PMID 31163352 DOI: 10.1016/j.virol.2019.05.016  0.76
2018 Akhrymuk I, Lukash T, Frolov I, Frolova EI. Novel mutations in nsP2 abolish chikungunya virus-induced transcriptional shutoff and make virus less cytopathic without affecting its replication rates. Journal of Virology. PMID 30487275 DOI: 10.1128/JVI.02062-18  0.76
2018 Akhrymuk I, Frolov I, Frolova EI. Sindbis virus infection causes cell death by nsP2-induced transcriptional shutoff or by nsP3-dependent translational shutoff. Journal of Virology. PMID 30232189 DOI: 10.1128/JVI.01388-18  0.76
2018 Meshram CD, Agback P, Shiliaev N, Urakova N, Mobley JA, Agback T, Frolova EI, Frolov I. Multiple Host Factors Interact with Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode. Journal of Virology. PMID 29899097 DOI: 10.1128/JVI.00838-18  0.76
2017 Erasmus JH, Seymour RL, Kaelber JT, Kim DY, Leal G, Sherman MB, Frolov I, Chiu W, Weaver SC, Nasar F. Novel insect-specific Eilat virus-based chimeric vaccine candidates provide durable, mono- and multi-valent, single dose protection against lethal alphavirus challenge. Journal of Virology. PMID 29187545 DOI: 10.1128/JVI.01274-17  0.4
2017 Urakova N, Kuznetsova V, Crossman DK, Sokratian A, Guthrie DB, Kolykhalov AA, Lockwood MA, Natchus MG, Crowley MR, Painter GR, Frolova EI, Frolov I. β-D-N(4)-hydroxycytidine is a potent anti-alphavirus compound that induces high level of mutations in viral genome. Journal of Virology. PMID 29167335 DOI: 10.1128/JVI.01965-17  0.76
2017 Frolov I, Kim DY, Akhrymuk M, Mobley JA, Frolova EI. Hypervariable Domain of Eastern Equine Encephalitis Virus nsP3 Redundantly Utilizes Multiple Cellular Proteins for Replication Complex Assembly. Journal of Virology. PMID 28468889 DOI: 10.1128/JVI.00371-17  0.76
2016 Erasmus JH, Auguste AJ, Kaelber JT, Luo H, Rossi SL, Fenton K, Leal G, Kim DY, Chiu W, Wang T, Frolov I, Nasar F, Weaver SC. A chikungunya fever vaccine utilizing an insect-specific virus platform. Nature Medicine. PMID 27991917 DOI: 10.1038/nm.4253  0.4
2016 Kim DY, Reynaud JM, Rasalouskaya A, Akhrymuk I, Mobley JA, Frolov I, Frolova EI. New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes. Plos Pathogens. 12: e1005810. PMID 27509095 DOI: 10.1371/journal.ppat.1005810  0.76
2016 Akhrymuk I, Frolov I, Frolova EI. Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode. Virology. 487: 230-41. PMID 26550947 DOI: 10.1016/j.virol.2015.09.023  0.76
2015 Reynaud JM, Lulla V, Kim DY, Frolova EI, Frolov I. The SD1 Subdomain of Venezuelan Equine Encephalitis Virus Capsid Protein Plays a Critical Role in Nucleocapsid and Particle Assembly. Journal of Virology. PMID 26656680 DOI: 10.1128/JVI.02680-15  0.76
2015 Erasmus JH, Needham J, Raychaudhuri S, Diamond MS, Beasley DW, Morkowski S, Salje H, Fernandez Salas I, Kim DY, Frolov I, Nasar F, Weaver SC. Utilization of an Eilat Virus-Based Chimera for Serological Detection of Chikungunya Infection. Plos Neglected Tropical Diseases. 9: e0004119. PMID 26492074 DOI: 10.1371/journal.pntd.0004119  0.76
2015 Reynaud JM, Kim DY, Atasheva S, Rasalouskaya A, White JP, Diamond MS, Weaver SC, Frolova EI, Frolov I. IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon. Plos Pathogens. 11: e1004863. PMID 25927359 DOI: 10.1371/journal.ppat.1004863  0.76
2015 Atasheva S, Kim DY, Frolova EI, Frolov I. Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype. Journal of Virology. 89: 71-82. PMID 25320296 DOI: 10.1128/JVI.02252-14  0.76
2014 Kim DY, Atasheva S, McAuley AJ, Plante JA, Frolova EI, Beasley DW, Frolov I. Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs. Proceedings of the National Academy of Sciences of the United States of America. 111: 10708-13. PMID 25002490 DOI: 10.1073/pnas.1408677111  0.76
2014 Atasheva S, Frolova EI, Frolov I. Interferon-stimulated poly(ADP-Ribose) polymerases are potent inhibitors of cellular translation and virus replication. Journal of Virology. 88: 2116-30. PMID 24335297 DOI: 10.1128/JVI.03443-13  0.76
2013 Lulla V, Kim DY, Frolova EI, Frolov I. The amino-terminal domain of alphavirus capsid protein is dispensable for viral particle assembly but regulates RNA encapsidation through cooperative functions of its subdomains. Journal of Virology. 87: 12003-19. PMID 24006447 DOI: 10.1128/JVI.01960-13  0.76
2013 Guerbois M, Volkova E, Forrester NL, Rossi SL, Frolov I, Weaver SC. IRES-driven expression of the capsid protein of the Venezuelan equine encephalitis virus TC-83 vaccine strain increases its attenuation and safety. Plos Neglected Tropical Diseases. 7: e2197. PMID 23675542 DOI: 10.1371/journal.pntd.0002197  0.76
2013 Foy NJ, Akhrymuk M, Shustov AV, Frolova EI, Frolov I. Hypervariable domain of nonstructural protein nsP3 of Venezuelan equine encephalitis virus determines cell-specific mode of virus replication. Journal of Virology. 87: 7569-84. PMID 23637407 DOI: 10.1128/JVI.00720-13  0.76
2013 Kim DY, Atasheva S, Frolova EI, Frolov I. Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions. Journal of Virology. 87: 4202-13. PMID 23365438 DOI: 10.1128/JVI.03142-12  0.76
2013 Roy CJ, Adams AP, Wang E, Leal G, Seymour RL, Sivasubramani SK, Mega W, Frolov I, Didier PJ, Weaver SC. A chimeric Sindbis-based vaccine protects cynomolgus macaques against a lethal aerosol challenge of eastern equine encephalitis virus. Vaccine. 31: 1464-70. PMID 23333212 DOI: 10.1016/j.vaccine.2013.01.014  0.76
2013 Foy NJ, Akhrymuk M, Akhrymuk I, Atasheva S, Bopda-Waffo A, Frolov I, Frolova EI. Hypervariable domains of nsP3 proteins of New World and Old World alphaviruses mediate formation of distinct, virus-specific protein complexes. Journal of Virology. 87: 1997-2010. PMID 23221551 DOI: 10.1128/JVI.02853-12  0.76
2013 Atasheva S, Kim DY, Akhrymuk M, Morgan DG, Frolova EI, Frolov I. Pseudoinfectious Venezuelan equine encephalitis virus: a new means of alphavirus attenuation. Journal of Virology. 87: 2023-35. PMID 23221545 DOI: 10.1128/JVI.02881-12  0.76
2012 Atasheva S, Akhrymuk M, Frolova EI, Frolov I. New PARP gene with an anti-alphavirus function. Journal of Virology. 86: 8147-60. PMID 22623789 DOI: 10.1128/JVI.00733-12  0.76
2012 Frolov I, Akhrymuk M, Akhrymuk I, Atasheva S, Frolova EI. Early events in alphavirus replication determine the outcome of infection. Journal of Virology. 86: 5055-66. PMID 22345447 DOI: 10.1128/JVI.07223-11  0.76
2011 Plante K, Wang E, Partidos CD, Weger J, Gorchakov R, Tsetsarkin K, Borland EM, Powers AM, Seymour R, Stinchcomb DT, Osorio JE, Frolov I, Weaver SC. Novel chikungunya vaccine candidate with an IRES-based attenuation and host range alteration mechanism. Plos Pathogens. 7: e1002142. PMID 21829348 DOI: 10.1371/journal.ppat.1002142  0.76
2011 Wang E, Kim DY, Weaver SC, Frolov I. Chimeric Chikungunya viruses are nonpathogenic in highly sensitive mouse models but efficiently induce a protective immune response. Journal of Virology. 85: 9249-52. PMID 21697494 DOI: 10.1128/JVI.00844-11  0.76
2011 Kim DY, Firth AE, Atasheva S, Frolova EI, Frolov I. Conservation of a packaging signal and the viral genome RNA packaging mechanism in alphavirus evolution. Journal of Virology. 85: 8022-36. PMID 21680508 DOI: 10.1128/JVI.00644-11  0.76
2011 Kim DY, Atasheva S, Foy NJ, Wang E, Frolova EI, Weaver S, Frolov I. Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype. Journal of Virology. 85: 4363-76. PMID 21345954 DOI: 10.1128/JVI.00065-11  0.76
2010 Frolova EI, Gorchakov R, Pereboeva L, Atasheva S, Frolov I. Functional Sindbis virus replicative complexes are formed at the plasma membrane. Journal of Virology. 84: 11679-95. PMID 20826696 DOI: 10.1128/JVI.01441-10  0.76
2010 Atasheva S, Krendelchtchikova V, Liopo A, Frolova E, Frolov I. Interplay of acute and persistent infections caused by Venezuelan equine encephalitis virus encoding mutated capsid protein. Journal of Virology. 84: 10004-15. PMID 20668087 DOI: 10.1128/JVI.01151-10  0.76
2010 Shustov AV, Frolov I. Efficient, trans-complementing packaging systems for chimeric, pseudoinfectious dengue 2/yellow fever viruses. Virology. 400: 8-17. PMID 20137799 DOI: 10.1016/j.virol.2009.12.015  0.52
2010 McGee CE, Shustov AV, Tsetsarkin K, Frolov IV, Mason PW, Vanlandingham DL, Higgs S. Infection, dissemination, and transmission of a West Nile virus green fluorescent protein infectious clone by Culex pipiens quinquefasciatus mosquitoes. Vector Borne and Zoonotic Diseases (Larchmont, N.Y.). 10: 267-74. PMID 19619041 DOI: 10.1089/vbz.2009.0067  0.76
2009 Frolov I, Garmashova N, Atasheva S, Frolova EI. Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcription. Journal of Virology. 83: 9031-44. PMID 19570872 DOI: 10.1128/JVI.00850-09  0.76
2009 Kulasegaran-Shylini R, Atasheva S, Gorenstein DG, Frolov I. Structural and functional elements of the promoter encoded by the 5′ untranslated region of the Venezuelan equine encephalitis virus genome Journal of Virology. 83: 8327-8339. PMID 19515761 DOI: 10.1128/JVI.00586-09  0.76
2009 Atasheva S, Wang E, Adams AP, Plante KS, Ni S, Taylor K, Miller ME, Frolov I, Weaver SC. Chimeric alphavirus vaccine candidates protect mice from intranasal challenge with western equine encephalitis virus. Vaccine. 27: 4309-19. PMID 19446595 DOI: 10.1016/j.vaccine.2009.05.011  0.76
2009 Kulasegaran-Shylini R, Thiviyanathan V, Gorenstein DG, Frolov I. The 5′UTR-specific mutation in VEEV TC-83 genome has a strong effect on RNA replication and subgenomic RNA synthesis, but not on translation of the encoded proteins Virology. 387: 211-221. PMID 19278709 DOI: 10.1016/j.virol.2009.02.027  0.76
2008 Wang E, Volkova E, Adams AP, Forrester N, Xiao SY, Frolov I, Weaver SC. Chimeric alphavirus vaccine candidates for chikungunya. Vaccine. 26: 5030-9. PMID 18692107 DOI: 10.1016/j.vaccine.2008.07.054  0.76
2008 Gorchakov R, Garmashova N, Frolova E, Frolov I. Different types of nsP3-containing protein complexes in Sindbis virus-infected cells. Journal of Virology. 82: 10088-101. PMID 18684830 DOI: 10.1128/JVI.01011-08  0.68
2008 Volkova E, Frolova E, Darwin JR, Forrester NL, Weaver SC, Frolov I. IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells. Virology. 377: 160-9. PMID 18501401 DOI: 10.1016/j.virol.2008.04.020  0.76
2008 Gorchakov R, Frolova E, Sawicki S, Atasheva S, Sawicki D, Frolov I. A new role for ns polyprotein cleavage in Sindbis virus replication. Journal of Virology. 82: 6218-31. PMID 18417571 DOI: 10.1128/JVI.02624-07  0.76
2008 Aguilar PV, Adams AP, Wang E, Kang W, Carrara AS, Anishchenko M, Frolov I, Weaver SC. Structural and nonstructural protein genome regions of eastern equine encephalitis virus are determinants of interferon sensitivity and murine virulence. Journal of Virology. 82: 4920-30. PMID 18353963 DOI: 10.1128/JVI.02514-07  0.76
2008 Atasheva S, Garmashova N, Frolov I, Frolova E. Venezuelan equine encephalitis virus capsid protein inhibits nuclear import in Mammalian but not in mosquito cells. Journal of Virology. 82: 4028-41. PMID 18256144 DOI: 10.1128/JVI.02330-07  0.76
2008 Arrigo NC, Watts DM, Frolov I, Weaver SC. Experimental infection of Aedes sollicitans and Aedes taeniorhynchus with two chimeric Sindbis/Eastern equine encephalitis virus vaccine candidates. The American Journal of Tropical Medicine and Hygiene. 78: 93-7. PMID 18187790  0.76
2007 Garmashova N, Atasheva S, Kang W, Weaver SC, Frolova E, Frolov I. Analysis of Venezuelan equine encephalitis virus capsid protein function in the inhibition of cellular transcription. Journal of Virology. 81: 13552-65. PMID 17913819 DOI: 10.1128/JVI.01576-07  0.76
2007 Wang E, Petrakova O, Adams AP, Aguilar PV, Kang W, Paessler S, Volk SM, Frolov I, Weaver SC. Chimeric Sindbis/eastern equine encephalitis vaccine candidates are highly attenuated and immunogenic in mice. Vaccine. 25: 7573-81. PMID 17904699 DOI: 10.1016/j.vaccine.2007.07.061  0.76
2007 Shustov AV, Mason PW, Frolov I. Production of pseudoinfectious yellow fever virus with a two-component genome. Journal of Virology. 81: 11737-48. PMID 17715227 DOI: 10.1128/JVI.01112-07  0.52
2007 Paessler S, Yun NE, Judy BM, Dziuba N, Zacks MA, Grund AH, Frolov I, Campbell GA, Weaver SC, Estes DM. Alpha-beta T cells provide protection against lethal encephalitis in the murine model of VEEV infection. Virology. 367: 307-23. PMID 17610927 DOI: 10.1016/j.virol.2007.05.041  0.76
2007 Gorchakov R, Volkova E, Yun N, Petrakova O, Linde NS, Paessler S, Frolova E, Frolov I. Comparative analysis of the alphavirus-based vectors expressing Rift Valley fever virus glycoproteins. Virology. 366: 212-25. PMID 17507072 DOI: 10.1016/j.virol.2007.04.014  0.48
2007 Ni H, Yun NE, Zacks MA, Weaver SC, Tesh RB, da Rosa AP, Powers AM, Frolov I, Paessler S. Recombinant alphaviruses are safe and useful serological diagnostic tools. The American Journal of Tropical Medicine and Hygiene. 76: 774-81. PMID 17426186 DOI: 10.4269/ajtmh.2007.76.774  0.76
2007 Atasheva S, Gorchakov R, English R, Frolov I, Frolova E. Development of Sindbis viruses encoding nsP2/GFP chimeric proteins and their application for studying nsP2 functioning. Journal of Virology. 81: 5046-57. PMID 17329335 DOI: 10.1128/JVI.02746-06  0.76
2007 Michel G, Petrakova O, Atasheva S, Frolov I. Adaptation of Venezuelan equine encephalitis virus lacking 51-nt conserved sequence element to replication in mammalian and mosquito cells. Virology. 362: 475-87. PMID 17292936 DOI: 10.1016/j.virol.2007.01.009  0.76
2007 Garmashova N, Gorchakov R, Volkova E, Paessler S, Frolova E, Frolov I. The Old World and New World alphaviruses use different virus-specific proteins for induction of transcriptional shutoff. Journal of Virology. 81: 2472-84. PMID 17108023 DOI: 10.1128/JVI.02073-06  0.68
2006 Garmashova N, Gorchakov R, Frolova E, Frolov I. Sindbis virus nonstructural protein nsP2 is cytotoxic and inhibits cellular transcription. Journal of Virology. 80: 5686-96. PMID 16731907 DOI: 10.1128/JVI.02739-05  0.68
2006 Mason PW, Shustov AV, Frolov I. Production and characterization of vaccines based on flaviviruses defective in replication. Virology. 351: 432-43. PMID 16712897 DOI: 10.1016/j.virol.2006.04.003  0.52
2006 Fayzulin R, Scholle F, Petrakova O, Frolov I, Mason PW. Evaluation of replicative capacity and genetic stability of West Nile virus replicons using highly efficient packaging cell lines. Virology. 351: 196-209. PMID 16647099 DOI: 10.1016/j.virol.2006.02.036  0.32
2006 Frolova E, Gorchakov R, Garmashova N, Atasheva S, Vergara LA, Frolov I. Formation of nsP3-specific protein complexes during Sindbis virus replication. Journal of Virology. 80: 4122-34. PMID 16571828 DOI: 10.1128/JVI.80.8.4122-4134.2006  0.76
2006 Paessler S, Ni H, Petrakova O, Fayzulin RZ, Yun N, Anishchenko M, Weaver SC, Frolov I. Replication and clearance of Venezuelan equine encephalitis virus from the brains of animals vaccinated with chimeric SIN/VEE viruses. Journal of Virology. 80: 2784-96. PMID 16501087 DOI: 10.1128/JVI.80.6.2784-2796.2006  0.32
2006 Volkova E, Gorchakov R, Frolov I. The efficient packaging of Venezuelan equine encephalitis virus-specific RNAs into viral particles is determined by nsP1-3 synthesis. Virology. 344: 315-27. PMID 16239019 DOI: 10.1016/j.virol.2005.09.010  0.4
2005 Gorchakov R, Frolova E, Frolov I. Inhibition of transcription and translation in Sindbis virus-infected cells. Journal of Virology. 79: 9397-409. PMID 16014903 DOI: 10.1128/JVI.79.15.9397-9409.2005  0.48
2005 Petrakova O, Volkova E, Gorchakov R, Paessler S, Kinney RM, Frolov I. Noncytopathic replication of Venezuelan equine encephalitis virus and eastern equine encephalitis virus replicons in Mammalian cells. Journal of Virology. 79: 7597-608. PMID 15919912 DOI: 10.1128/JVI.79.12.7597-7608.2005  0.4
2005 Greene IP, Paessler S, Anishchenko M, Smith DR, Brault AC, Frolov I, Weaver SC. Venezuelan equine encephalitis virus in the guinea pig model: evidence for epizootic virulence determinants outside the E2 envelope glycoprotein gene. The American Journal of Tropical Medicine and Hygiene. 72: 330-8. PMID 15772331  0.76
2005 Lee YM, Tscherne DM, Yun SI, Frolov I, Rice CM. Dual mechanisms of pestiviral superinfection exclusion at entry and RNA replication. Journal of Virology. 79: 3231-42. PMID 15731218 DOI: 10.1128/JVI.79.6.3231-3242.2005  0.76
2005 Fayzulin R, Gorchakov R, Petrakova O, Volkova E, Frolov I. Sindbis virus with a tricomponent genome. Journal of Virology. 79: 637-43. PMID 15596860 DOI: 10.1128/JVI.79.1.637-643.2005  0.4
2004 Gorchakov R, Frolova E, Williams BR, Rice CM, Frolov I. PKR-dependent and -independent mechanisms are involved in translational shutoff during Sindbis virus infection. Journal of Virology. 78: 8455-67. PMID 15280454 DOI: 10.1128/JVI.78.16.8455-8467.2004  0.48
2004 Agapov EV, Murray CL, Frolov I, Qu L, Myers TM, Rice CM. Uncleaved NS2-3 is required for production of infectious bovine viral diarrhea virus. Journal of Virology. 78: 2414-25. PMID 14963137 DOI: 10.1128/JVI.78.5.2414-2425.2004  0.76
2004 Gorchakov R, Hardy R, Rice CM, Frolov I. Selection of functional 5' cis-acting elements promoting efficient sindbis virus genome replication. Journal of Virology. 78: 61-75. PMID 14671088  0.4
2003 Paessler S, Fayzulin RZ, Anishchenko M, Greene IP, Weaver SC, Frolov I. Recombinant sindbis/Venezuelan equine encephalitis virus is highly attenuated and immunogenic. Journal of Virology. 77: 9278-86. PMID 12915543 DOI: 10.1128/JVI.77.17.9278-9286.2003  0.76
2002 Frolova EI, Fayzulin RZ, Cook SH, Griffin DE, Rice CM, Frolov I. Roles of nonstructural protein nsP2 and Alpha/Beta interferons in determining the outcome of Sindbis virus infection. Journal of Virology. 76: 11254-64. PMID 12388685 DOI: 10.1128/JVI.76.22.11254-11264.2002  0.76
2001 Myers TM, Kolupaeva VG, Mendez E, Baginski SG, Frolov I, Hellen CU, Rice CM. Efficient translation initiation is required for replication of bovine viral diarrhea virus subgenomic replicons. Journal of Virology. 75: 4226-38. PMID 11287572 DOI: 10.1128/JVI.75.9.4226-4238.2001  0.76
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