Fuyuhiko Tamanoi - Publications

Affiliations: 
Microbiology, Immunology, & Molecular Genetics 0440 University of California, Los Angeles, Los Angeles, CA 
Area:
Nanotechnology, Cell Biology

144 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Chantaravisoot N, Wongkongkathep P, Kalpongnukul N, Pacharakullanon N, Kaewsapsak P, Ariyachet C, Loo JA, Tamanoi F, Pisitkun T. mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin. Scientific Reports. 13: 7037. PMID 37120454 DOI: 10.1038/s41598-023-33872-y  0.806
2020 Nasimian A, Farzaneh P, Tamanoi F, Zahra Bathaie S. Cytosolic and mitochondrial ROS production resulted in apoptosis induction in breast cancer cells treated with Crocin: The role of FOXO3a, PTEN and AKT signaling. Biochemical Pharmacology. 113999. PMID 32353423 DOI: 10.1016/J.Bcp.2020.113999  0.351
2020 Tamanoi F, Mai NXD, Birault A, Matsumoto K, Ta HKT, Intasa-Ard SG, Morrison K, Thang PB, Doan TLH. Biodegradable Periodic Mesoporous Organosilica (BPMO) loaded with Daunorubicin: A Promising Nanoparticle-based Anti-cancer Drug. Chemmedchem. PMID 32020745 DOI: 10.1002/Cmdc.201900595  0.305
2019 Chantaravisoot N, Wongkongkathep P, Pacharakullanon N, Tamanoi F, Loo JA, Pisitkun T. Abstract 4535: The mTOR complex 2 promotes glioblastoma migration via the interactions with multiple actin-binding and microtubule-associated proteins Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-4535  0.732
2018 Matsumoto K, Le Hoang Doan T, Mai NXD, Nakai K, Komatsu A, Tamanoi F. Anticancer Drug Delivery Capability of Biodegradable PMO in the Chicken Egg Tumor Model. The Enzymes. 44: 103-116. PMID 30360810 DOI: 10.1016/Bs.Enz.2018.09.003  0.301
2018 Vu BT, Shahin SA, Croissant J, Fatieiev Y, Matsumoto K, Le-Hoang Doan T, Yik T, Simargi S, Conteras A, Ratliff L, Jimenez CM, Raehm L, Khashab N, Durand JO, Glackin C, ... Tamanoi F, et al. Chick chorioallantoic membrane assay as an in vivo model to study the effect of nanoparticle-based anticancer drugs in ovarian cancer. Scientific Reports. 8: 8524. PMID 29867159 DOI: 10.1038/S41598-018-25573-8  0.32
2018 Shahin SA, Wang R, Simargi SI, Contreras A, Parra L, Qu L, Wen W, Dellinger T, Unternaehrer J, Tamanoi F, Zink JI, Glackin CA. Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 29665439 DOI: 10.1016/J.Nano.2018.04.008  0.389
2018 Faridi N, Bathaie SZ, Abroun S, Farzaneh P, Karbasian H, Tamanoi F, Mohagheghi MA. Isolation and characterization of the primary epithelial breast cancer cells and the adjacent normal epithelial cells from Iranian women's breast cancer tumors. Cytotechnology. PMID 29380298 DOI: 10.1007/S10616-017-0159-3  0.363
2018 Heard JJ, Phung I, Potes MI, Tamanoi F. An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation. Bmc Cancer. 18: 69. PMID 29320991 DOI: 10.1186/S12885-017-3938-5  0.422
2018 Chantaravisoot N, Wongkongkathep P, Pacharakullanon N, Tamanoi F, Loo JA, Pisitkun T. Abstract 2702: The mTOR complex 2-associated interactome and cell migration ability determination in brain cancers Cancer Research. 78: 2702-2702. DOI: 10.1158/1538-7445.Am2018-2702  0.782
2018 Contreras A, Shahin SA, Ratliff LE, Simargi SI, Wang R, Vu B, Dellinger TH, Zink JI, Tamanoi F, Unternaehrer-Hamm J, Glackin CA. Abstract 2152: Optimizing therapies for drug-resistant ovarian cancer stem cells using aCAM-PDX model Cancer Research. 78: 2152-2152. DOI: 10.1158/1538-7445.Am2018-2152  0.362
2017 Tanaka A, Radwan MO, Hamasaki A, Ejima A, Obata E, Koga R, Tateishi H, Okamoto Y, Fujita M, Nakao M, Umezawa K, Tamanoi F, Otsuka M. A novel inhibitor of farnesyltransferase with a zinc site recognition moiety and a farnesyl group. Bioorganic & Medicinal Chemistry Letters. PMID 28666734 DOI: 10.1016/J.Bmcl.2017.06.047  0.314
2017 Belaid A, Filippakis H, Lam H, Valvezan A, Huang R, Xia M, Wen T, Baglini C, Sakamuru S, Asara J, Sinh NT, Heard JJ, Tamanoi F, Austin C, Manning B, et al. Abstract A09: Therapeutic targeting of TSC2-deficient cells with Methotrexate: Results of a drug repurposing screen Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Pmccavuln16-A09  0.413
2017 Chantaravisoot N, Wongkongkathep P, Tamanoi F, Pisitkun T. Abstract 219: Identification of the mechanistic target of rapamycin complex 2-associated interactome involved in brain cancer cell motility by affinity purification-mass spectrometry Cancer Research. 77: 219-219. DOI: 10.1158/1538-7445.Am2017-219  0.731
2016 Roberts CM, Shahin SA, Wen W, Finlay JB, Dong J, Wang R, Dellinger TH, Zink JI, Tamanoi F, Glackin CA. Nanoparticle delivery of siRNA against TWIST to reduce drug resistance and tumor growth in ovarian cancer models. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 27890656 DOI: 10.1016/J.Nano.2016.11.010  0.356
2016 Croissant J, Fatieiev Y, Julfakyan K, Lu J, Emwas A, Anjum D, Omar H, Tamanoi F, Zink J, Khashab N. Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27258139 DOI: 10.1002/Chem.201601714  0.343
2016 Croissant JG, Fatieiev Y, Omar H, Anjum DH, Gurinov A, Lu J, Tamanoi F, Zink JI, Khashab NM. Periodic Mesoporous Organosilica Nanoparticles with Controlled Morphologies and High Drug/Dye Loadings for Multicargo Delivery in Cancer Cells. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27245497 DOI: 10.1002/Chem.201600587  0.305
2016 Croissant JG, Zhang D, Alsaiari S, Lu J, Deng L, Tamanoi F, Zink JI, Khashab NM. Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 27016140 DOI: 10.1016/J.Jconrel.2016.03.030  0.31
2016 Zahra Bathaie S, Ashrafi M, Azizian M, Tamanoi F. Mevalonate Pathway and Human Cancers. Current Molecular Pharmacology. PMID 26758953 DOI: 10.2174/1874467209666160112123205  0.429
2015 Lu J, Yoshimura K, Goto K, Lee C, Hamura K, Kwon O, Tamanoi F. Nanoformulation of Geranylgeranyltransferase-I Inhibitors for Cancer Therapy: Liposomal Encapsulation and pH-Dependent Delivery to Cancer Cells. Plos One. 10: e0137595. PMID 26352258 DOI: 10.1371/Journal.Pone.0137595  0.395
2015 Bathaie SZ, Faridi N, Nasimian A, Heidarzadeh H, Tamanoi F. How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth? The Enzymes. 37: 1-42. PMID 26298454 DOI: 10.1016/Bs.Enz.2015.06.003  0.345
2015 Chantaravisoot N, Wongkongkathep P, Loo JA, Mischel PS, Tamanoi F. Significance of filamin A in mTORC2 function in glioblastoma. Molecular Cancer. 14: 127. PMID 26134617 DOI: 10.1186/S12943-015-0396-Z  0.756
2015 Finlay J, Roberts CM, Dong J, Zink JI, Tamanoi F, Glackin CA. Mesoporous silica nanoparticle delivery of chemically modified siRNA against TWIST1 leads to reduced tumor burden. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 26115637 DOI: 10.1016/J.Nano.2015.05.011  0.318
2015 Mortazavi F, Lu J, Phan R, Lewis M, Trinidad K, Aljilani A, Pezeshkpour G, Tamanoi F. Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. Bmc Cancer. 15: 381. PMID 25956913 DOI: 10.1186/S12885-015-1360-4  0.327
2015 Sato T, Akasu H, Shimono W, Matsu C, Fujiwara Y, Shibagaki Y, Heard JJ, Tamanoi F, Hattori S. Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity. The Journal of Biological Chemistry. 290: 1096-105. PMID 25422319 DOI: 10.1074/Jbc.M114.592402  0.418
2015 Hwang AA, Lu J, Tamanoi F, Zink JI. Functional nanovalves on protein-coated nanoparticles for in vitro and in vivo controlled drug delivery. Small (Weinheim An Der Bergstrasse, Germany). 11: 319-28. PMID 25196485 DOI: 10.1002/Smll.201400765  0.369
2015 Chantaravisoot N, Wongkongkathep P, Loo JA, Mischel PS, Tamanoi F. Significance of filamin A in mTORC2 function in glioblastoma Molecular Cancer. 14. DOI: 10.1186/s12943-015-0396-z  0.675
2015 Finlay JB, Roberts CM, Lowe G, Peng L, Zink JI, Tamanoi F, Glackin CA. Abstract P2-07-04: Treatment of metastatic breast cancer using two nanoparticles combined with siRNA targeting Twist1 to inhibit EMT Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P2-07-04  0.373
2014 Bathaie SZ, Bolhassani A, Tamanoi F. Anticancer Effect and Molecular Targets of Saffron Carotenoids. The Enzymes. 36: 57-86. PMID 27102699 DOI: 10.1016/B978-0-12-802215-3.00004-5  0.315
2014 Nakashima A, Kamada S, Tamanoi F, Kikkawa U. Fission yeast arrestin-related trafficking adaptor, Arn1/Any1, is ubiquitinated by Pub1 E3 ligase and regulates endocytosis of Cat1 amino acid transporter. Biology Open. 3: 542-52. PMID 24876389 DOI: 10.1242/Bio.20148367  0.33
2014 Heard JJ, Fong V, Bathaie SZ, Tamanoi F. Recent progress in the study of the Rheb family GTPases Cellular Signalling. 26: 1950-1957. PMID 24863881 DOI: 10.1016/J.Cellsig.2014.05.011  0.373
2014 Croissant J, Chaix A, Mongin O, Wang M, Clément S, Raehm L, Durand JO, Hugues V, Blanchard-Desce M, Maynadier M, Gallud A, Gary-Bobo M, Garcia M, Lu J, Tamanoi F, et al. Two-photon-triggered drug delivery via fluorescent nanovalves. Small (Weinheim An Der Bergstrasse, Germany). 10: 1752-5. PMID 24678053 DOI: 10.1002/Smll.201400042  0.315
2014 Mortazavi F(, Lu J, Amir A, Phan R, Tamanoi F. Abstract A36: Interruption of K-Ras/PAK1/Crk pathway has a dramatic anti-tumor effect in NSCLC Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-A36  0.34
2014 lu J, Croissant J, Durand JJ, Guardado-Alvarez T, Zink JI, Tamanoi F. Abstract LB-9: Light-controllable nano-drug delivery system with deep tissue penetrating ability for cancer therapy with two-photon-triggered nanoimpellers Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-9  0.326
2013 Tamanoi F, Der CJ. Inhibitors of the Ras superfamily of small G-proteins. Preface. The Enzymes. 34: ix. PMID 25034107 DOI: 10.1016/B978-0-12-420146-0.09985-6  0.36
2013 Tamanoi F, Lu J. Recent progress in developing small molecule inhibitors designed to interfere with ras membrane association: toward inhibiting K-Ras and N-Ras functions. The Enzymes. 34: 181-200. PMID 25034105 DOI: 10.1016/B978-0-12-420146-0.00008-1  0.338
2013 Khazak V, Eyrisch S, Kato J, Tamanoi F, Golemis EA. A two-hybrid approach to identify inhibitors of the RAS-RAF interaction. The Enzymes. 33: 213-48. PMID 25033807 DOI: 10.1016/B978-0-12-416749-0.00010-5  0.363
2013 Tetlow AL, Tamanoi F. The Ras superfamily G-proteins. The Enzymes. 33: 1-14. PMID 25033798 DOI: 10.1016/B978-0-12-416749-0.00001-4  0.413
2013 Croissant J, Maynadier M, Gallud A, Peindy N'dongo H, Nyalosaso JL, Derrien G, Charnay C, Durand JO, Raehm L, Serein-Spirau F, Cheminet N, Jarrosson T, Mongin O, Blanchard-Desce M, Gary-Bobo M, ... ... Tamanoi F, et al. Two-photon-triggered drug delivery in cancer cells using nanoimpellers. Angewandte Chemie (International Ed. in English). 52: 13813-7. PMID 24214916 DOI: 10.1002/Anie.201308647  0.316
2013 Zimonjic DB, Chan LN, Tripathi V, Lu J, Kwon O, Popescu NC, Lowy DR, Tamanoi F. In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells. Bmc Cancer. 13: 198. PMID 23607551 DOI: 10.1186/1471-2407-13-198  0.66
2013 Akhavan D, Pourzia AL, Nourian AA, Williams KJ, Nathanson D, Babic I, Villa GR, Tanaka K, Nael A, Yang H, Dang J, Vinters HV, Yong WH, Flagg M, Tamanoi F, et al. De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients. Cancer Discovery. 3: 534-47. PMID 23533263 DOI: 10.1158/2159-8290.Cd-12-0502  0.329
2013 Yanes RE, Tarn D, Hwang AA, Ferris DP, Sherman SP, Thomas CR, Lu J, Pyle AD, Zink JI, Tamanoi F. Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition. Small (Weinheim An Der Bergstrasse, Germany). 9: 697-704. PMID 23152124 DOI: 10.1002/Smll.201201811  0.769
2012 Nakashima A, Otsubo Y, Yamashita A, Sato T, Yamamoto M, Tamanoi F. Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase Journal of Cell Science. 125: 5840-5849. PMID 22976295 DOI: 10.1242/Jcs.111146  0.36
2012 Rettig M, Trinidad K, Pezeshkpour G, Frost P, Sharma S, Moatamed F, Tamanoi F, Mortazavi F. PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cells. Plos One. 7: e42012. PMID 22848689 DOI: 10.1371/Journal.Pone.0042012  0.369
2012 Lau YA, Henderson BL, Lu J, Ferris DP, Tamanoi F, Zink JI. Continuous spectroscopic measurements of photo-stimulated release of molecules by nanomachines in a single living cell. Nanoscale. 4: 3482-9. PMID 22552632 DOI: 10.1039/C2Nr30524K  0.339
2012 Yanes RE, Tamanoi F. Development of mesoporous silica nanomaterials as a vehicle for anticancer drug delivery. Therapeutic Delivery. 3: 389-404. PMID 22506096 DOI: 10.4155/Tde.12.9  0.769
2012 Lu J, Li Z, Zink JI, Tamanoi F. In vivo tumor suppression efficacy of mesoporous silica nanoparticles-based drug-delivery system: enhanced efficacy by folate modification. Nanomedicine : Nanotechnology, Biology, and Medicine. 8: 212-20. PMID 21703996 DOI: 10.1016/J.Nano.2011.06.002  0.302
2012 Yanes RE, Lu J, Tamanoi F. Nanoparticle-Based Delivery of siRNA and miRNA for Cancer Therapy Enzymes. 32: 185-203. DOI: 10.1016/B978-0-12-404741-9.00009-X  0.771
2011 Chan LN, Fiji HD, Watanabe M, Kwon O, Tamanoi F. Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I. Plos One. 6: e26135. PMID 22028818 DOI: 10.1371/Journal.Pone.0026135  0.635
2011 Tamanoi F. Ras signaling in yeast. Genes & Cancer. 2: 210-5. PMID 21779494 DOI: 10.1177/1947601911407322  0.349
2011 Ferris DP, Lu J, Gothard C, Yanes R, Thomas CR, Olsen JC, Stoddart JF, Tamanoi F, Zink JI. Synthesis of biomolecule-modified mesoporous silica nanoparticles for targeted hydrophobic drug delivery to cancer cells. Small (Weinheim An Der Bergstrasse, Germany). 7: 1816-26. PMID 21595023 DOI: 10.1002/Smll.201002300  0.79
2011 Hardt M, Chantaravisoot N, Tamanoi F. Activating mutations of TOR (target of rapamycin). Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 16: 141-51. PMID 21210909 DOI: 10.1111/J.1365-2443.2010.01482.X  0.765
2011 Chan LN, Watanabe M, Kwon O, Tamanoi F. Small-Molecule Inhibitors of GGTase-I from the Heterocycle Library Derived from Phosphine Catalysis Enzymes. 30: 165-177. DOI: 10.1016/B978-0-12-415922-8.00007-0  0.542
2011 Chan LN, Tamanoi F. Global Analysis of Prenylated Proteins by the Use of a Tagging via Substrate Approach Enzymes. 29: 195-206. DOI: 10.1016/B978-0-12-381339-8.00011-1  0.637
2010 Nakashima A, Tamanoi F. Conservation of the Tsc/Rheb/TORC1/S6K/S6 Signaling in Fission Yeast. The Enzymes. 28: 167-187. PMID 25814783 DOI: 10.1016/S1874-6047(10)28008-3  0.401
2010 Parmar N, Tamanoi F. Rheb G-Proteins and the Activation of mTORC1. The Enzymes. 27: 39-56. PMID 25429186 DOI: 10.1016/S1874-6047(10)27003-8  0.446
2010 Meng H, Xue M, Xia T, Zhao YL, Tamanoi F, Stoddart JF, Zink JI, Nel AE. Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves. Journal of the American Chemical Society. 132: 12690-7. PMID 20718462 DOI: 10.1021/Ja104501A  0.318
2010 Hom C, Lu J, Liong M, Luo H, Li Z, Zink JI, Tamanoi F. Mesoporous silica nanoparticles facilitate delivery of siRNA to shutdown signaling pathways in mammalian cells. Small (Weinheim An Der Bergstrasse, Germany). 6: 1185-90. PMID 20461725 DOI: 10.1002/Smll.200901966  0.351
2010 Sato T, Nakashima A, Guo L, Coffman K, Tamanoi F. Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer. Oncogene. 29: 2746-52. PMID 20190810 DOI: 10.1038/Onc.2010.28  0.481
2010 Nakashima A, Sato T, Tamanoi F. Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin. Journal of Cell Science. 123: 777-86. PMID 20144990 DOI: 10.1242/Jcs.060319  0.395
2010 Hanker AB, Mitin N, Wilder RS, Henske EP, Tamanoi F, Cox AD, Der CJ. Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. Oncogene. 29: 380-91. PMID 19838215 DOI: 10.1038/Onc.2009.336  0.4
2010 Tamanoi F. Abstract LB-243: Discovery of single amino acid changes that confer constitutive activation of mTOR in human cancer Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-243  0.462
2010 Chantaravisoot N, Tamanoi F. mTOR Signaling and Human Cancer The Enzymes. 28: 301-316. DOI: 10.1016/S1874-6047(10)28015-0  0.74
2009 Chan LN, Hart C, Guo L, Nyberg T, Davies BS, Fong LG, Young SG, Agnew BJ, Tamanoi F. A novel approach to tag and identify geranylgeranylated proteins. Electrophoresis. 30: 3598-606. PMID 19784953 DOI: 10.1002/Elps.200900259  0.621
2009 Lu J, Chan L, Fiji HD, Dahl R, Kwon O, Tamanoi F. In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I. Molecular Cancer Therapeutics. 8: 1218-26. PMID 19417142 DOI: 10.1158/1535-7163.Mct-08-1122  0.658
2009 Sato T, Nakashima A, Guo L, Tamanoi F. Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein. The Journal of Biological Chemistry. 284: 12783-91. PMID 19299511 DOI: 10.1074/Jbc.M809207200  0.405
2009 Zhou J, Vos CC, Gjyrezi A, Yoshida M, Khuri FR, Tamanoi F, Giannakakou P. The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner. The Journal of Biological Chemistry. 284: 9648-55. PMID 19228685 DOI: 10.1074/Jbc.M808708200  0.446
2008 Liong M, Lu J, Kovochich M, Xia T, Ruehm SG, Nel AE, Tamanoi F, Zink JI. Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery. Acs Nano. 2: 889-96. PMID 19206485 DOI: 10.1021/Nn800072T  0.336
2008 Short JD, Houston KD, Dere R, Cai SL, Kim J, Johnson CL, Broaddus RR, Shen J, Miyamoto S, Tamanoi F, Kwiatkowski D, Mills GB, Walker CL. AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27. Cancer Research. 68: 6496-506. PMID 18701472 DOI: 10.1158/0008-5472.Can-07-5756  0.356
2008 Sato T, Umetsu A, Tamanoi F. Characterization of the Rheb-mTOR signaling pathway in mammalian cells: constitutive active mutants of Rheb and mTOR. Methods in Enzymology. 438: 307-20. PMID 18413257 DOI: 10.1016/S0076-6879(07)38021-X  0.463
2008 Ikeda K, Morigasaki S, Tatebe H, Tamanoi F, Shiozaki K. Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control. Cell Cycle (Georgetown, Tex.). 7: 358-64. PMID 18235227 DOI: 10.4161/Cc.7.3.5245  0.396
2008 Watanabe M, Fiji HD, Guo L, Chan L, Kinderman SS, Slamon DJ, Kwon O, Tamanoi F. Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds. The Journal of Biological Chemistry. 283: 9571-9. PMID 18230616 DOI: 10.1074/Jbc.M706229200  0.623
2008 Aspuria PJ, Tamanoi F. The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast. Molecular Genetics and Genomics : Mgg. 279: 441-50. PMID 18219492 DOI: 10.1007/S00438-008-0320-Y  0.354
2007 Lu J, Liong M, Sherman S, Xia T, Kovochich M, Nel AE, Zink JI, Tamanoi F. Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells. Nanobiotechnology : the Journal At the Intersection of Nanotechnology, Molecular Biology, and Biomedical Sciences. 3: 89-95. PMID 19936038 DOI: 10.1007/S12030-008-9003-3  0.378
2007 Aspuria PJ, Sato T, Tamanoi F. The TSC/Rheb/TOR signaling pathway in fission yeast and mammalian cells: temperature sensitive and constitutive active mutants of TOR. Cell Cycle (Georgetown, Tex.). 6: 1692-5. PMID 17637564 DOI: 10.4161/Cc.6.14.4478  0.433
2007 Castellano S, Fiji HD, Kinderman SS, Watanabe M, Leon Pd, Tamanoi F, Kwon O. Small-molecule inhibitors of protein geranylgeranyltransferase type I. Journal of the American Chemical Society. 129: 5843-5. PMID 17439124 DOI: 10.1021/Ja070274N  0.368
2007 Yu F, Harada JN, Brown HJ, Deng H, Song MJ, Wu TT, Kato-Stankiewicz J, Nelson CG, Vieira J, Tamanoi F, Chanda SK, Sun R. Systematic identification of cellular signals reactivating Kaposi sarcoma-associated herpesvirus. Plos Pathogens. 3: e44. PMID 17397260 DOI: 10.1371/Journal.Ppat.0030044  0.351
2007 Urano J, Sato T, Matsuo T, Otsubo Y, Yamamoto M, Tamanoi F. Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells Proceedings of the National Academy of Sciences of the United States of America. 104: 3514-3519. PMID 17360675 DOI: 10.1073/Pnas.0608510104  0.46
2007 Matsuo T, Otsubo Y, Urano J, Tamanoi F, Yamamoto M. Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast Molecular and Cellular Biology. 27: 3154-3164. PMID 17261596 DOI: 10.1128/Mcb.01039-06  0.374
2006 Patel PH, Tamanoi F. Increased Rheb-TOR signaling enhances sensitivity of the whole organism to oxidative stress. Journal of Cell Science. 119: 4285-92. PMID 17038544 DOI: 10.1242/Jcs.03199  0.606
2006 Gelb MH, Brunsveld L, Hrycyna CA, Michaelis S, Tamanoi F, Van Voorhis WC, Waldmann H. Therapeutic intervention based on protein prenylation and associated modifications. Nature Chemical Biology. 2: 518-28. PMID 16983387 DOI: 10.1038/Nchembio818  0.379
2006 Patel PH, Tamanoi F. Using Drosophila and yeast genetics to investigate a role for the Rheb GTPase in cell growth. Methods in Enzymology. 407: 443-54. PMID 16757344 DOI: 10.1016/S0076-6879(05)07036-9  0.68
2005 Urano J, Comiso MJ, Guo L, Aspuria PJ, Deniskin R, Tabancay AP, Kato-Stankiewicz J, Tamanoi F. Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast. Molecular Microbiology. 58: 1074-86. PMID 16262791 DOI: 10.1111/J.1365-2958.2005.04877.X  0.729
2005 Gau CL, Kato-Stankiewicz J, Jiang C, Miyamoto S, Guo L, Tamanoi F. Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways. Molecular Cancer Therapeutics. 4: 918-26. PMID 15956249 DOI: 10.1158/1535-7163.Mct-04-0347  0.543
2004 Kho Y, Kim SC, Jiang C, Barma D, Kwon SW, Cheng J, Jaunbergs J, Weinbaum C, Tamanoi F, Falck J, Zhao Y. A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. Proceedings of the National Academy of Sciences of the United States of America. 101: 12479-84. PMID 15308774 DOI: 10.1073/Pnas.0403413101  0.522
2004 Aspuria PJ, Tamanoi F. The Rheb family of GTP-binding proteins. Cellular Signalling. 16: 1105-12. PMID 15240005 DOI: 10.1016/J.Cellsig.2004.03.019  0.487
2004 Uhlmann EJ, Li W, Scheidenhelm DK, Gau CL, Tamanoi F, Gutmann DH. Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation. Glia. 47: 180-8. PMID 15185396 DOI: 10.1002/Glia.20036  0.361
2004 Clarke S, Tamanoi F. Fighting cancer by disrupting C-terminal methylation of signaling proteins. The Journal of Clinical Investigation. 113: 513-5. PMID 14966560 DOI: 10.1172/Jci21059  0.389
2003 Patel PH, Thapar N, Guo L, Martinez M, Maris J, Gau CL, Lengyel JA, Tamanoi F. Drosophila Rheb GTPase is required for cell cycle progression and cell growth. Journal of Cell Science. 116: 3601-10. PMID 12893813 DOI: 10.1242/Jcs.00661  0.764
2003 Tabancay AP, Gau CL, Machado IM, Uhlmann EJ, Gutmann DH, Guo L, Tamanoi F. Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. The Journal of Biological Chemistry. 278: 39921-30. PMID 12869548 DOI: 10.1074/Jbc.M306553200  0.81
2003 Hamasaki A, Naka H, Tamanoi F, Umezawa K, Otsuka M. A novel metal-chelating inhibitor of protein farnesyltransferase. Bioorganic & Medicinal Chemistry Letters. 13: 1523-6. PMID 12699746 DOI: 10.1016/S0960-894X(03)00183-5  0.352
2002 Kato-Stankiewicz J, Hakimi I, Zhi G, Zhang J, Serebriiskii I, Guo L, Edamatsu H, Koide H, Menon S, Eckl R, Sakamuri S, Lu Y, Chen QZ, Agarwal S, Baumbach WR, ... ... Tamanoi F, et al. Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 99: 14398-403. PMID 12391290 DOI: 10.1073/Pnas.222222699  0.398
2001 Tamanoi F, Kato-Stankiewicz J, Jiang C, Machado I, Thapar N. Farnesylated proteins and cell cycle progression. Journal of Cellular Biochemistry. Supplement. 64-70. PMID 11842430 DOI: 10.1002/Jcb.10067  0.598
2001 Tamanoi F, Gau CL, Jiang C, Edamatsu H, Kato-Stankiewicz J. Protein farnesylation in mammalian cells: effects of farnesyltransferase inhibitors on cancer cells. Cellular and Molecular Life Sciences : Cmls. 58: 1636-49. PMID 11706990 DOI: 10.1007/Pl00000802  0.604
2001 Yang W, Tabancay AP, Urano J, Tamanoi F. Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant. Molecular Microbiology. 41: 1339-47. PMID 11580838 DOI: 10.1046/J.1365-2958.2001.02599.X  0.799
2001 Finlin BS, Gau CL, Murphy GA, Shao H, Kimel T, Seitz RS, Chiu YF, Botstein D, Brown PO, Der CJ, Tamanoi F, Andres DA, Perou CM. RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. The Journal of Biological Chemistry. 276: 42259-67. PMID 11533059 DOI: 10.1074/Jbc.M105888200  0.378
2001 Urano J, Ellis C, Clark GJ, Tamanoi F. Characterization of Rheb functions using yeast and mammalian systems. Methods in Enzymology. 333: 217-31. PMID 11400338 DOI: 10.1016/S0076-6879(01)33058-6  0.403
2001 Guo W, Tamanoi F, Novick P. Spatial regulation of the exocyst complex by Rho1 GTPase. Nature Cell Biology. 3: 353-60. PMID 11283608 DOI: 10.1038/35070029  0.336
2001 Urano J, Yang W, Tamanoi F. 3 Mutational analyses of protein farnesyltransferase The Enzymes. 21: 47-80. DOI: 10.1016/S1874-6047(01)80016-0  0.561
2001 Jiang C, Kato-Stankiewicz J, Gau C, Tamanoi F. Effects of farnesyltransferase inhibitors on cell cycle progression of human cancer cells Gene Function & Disease. 2: 99-107. DOI: 10.1002/1438-826X(200110)2:2/3<99::Aid-Gnfd99>3.0.Co;2-V  0.764
2000 Edamatsu H, Gau CL, Nemoto T, Guo L, Tamanoi F. Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines. Oncogene. 19: 3059-68. PMID 10871858 DOI: 10.1038/Sj.Onc.1203625  0.354
2000 Urano J, Tabancay AP, Yang W, Tamanoi F. The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake. The Journal of Biological Chemistry. 275: 11198-206. PMID 10753927 DOI: 10.1074/Jbc.275.15.11198  0.797
2000 Yang W, Urano J, Tamanoi F. Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe. The Journal of Biological Chemistry. 275: 429-38. PMID 10617635 DOI: 10.1074/Jbc.275.1.429  0.607
1999 Del Villar K, Urano J, Guo L, Tamanoi F. A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors. The Journal of Biological Chemistry. 274: 27010-7. PMID 10480914 DOI: 10.1074/Jbc.274.38.27010  0.429
1999 Robinson NG, Guo L, Imai J, Toh-E A, Matsui Y, Tamanoi F. Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70. Molecular and Cellular Biology. 19: 3580-7. PMID 10207081 DOI: 10.1128/Mcb.19.5.3580  0.436
1999 Suzuki N, Urano J, Tamanoi F. Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 15356-61. PMID 9860973 DOI: 10.1073/Pnas.95.26.15356  0.327
1998 Arellano M, Coll PM, Yang W, Duran A, Tamanoi F, Perez P. Characterization of the geranylgeranyl transferase type I from Schizosaccharomyces pombe. Molecular Microbiology. 29: 1357-67. PMID 9781874 DOI: 10.1046/J.1365-2958.1998.01009.X  0.55
1998 Suzuki N, Del Villar K, Tamanoi F. Farnesyltransferase inhibitors induce dramatic morphological changes of KNRK cells that are blocked by microtubule interfering agents. Proceedings of the National Academy of Sciences of the United States of America. 95: 10499-504. PMID 9724732 DOI: 10.1073/Pnas.95.18.10499  0.404
1998 Scoles DR, Huynh DP, Morcos PA, Coulsell ER, Robinson NG, Tamanoi F, Pulst SM. Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin. Nature Genetics. 18: 354-9. PMID 9537418 DOI: 10.1038/Ng0498-354  0.387
1997 Yang W, Del Villar K, Urano J, Mitsuzawa H, Tamanoi F. Advances in the development of farnesyltransferase inhibitors: substrate recognition by protein farnesyltransferase. Journal of Cellular Biochemistry. Supplement. 27: 12-9. PMID 9591188 DOI: 10.1002/(Sici)1097-4644(1997)27+<12::Aid-Jcb5>3.0.Co;2-4  0.539
1997 Upadhyaya M, Osborn MJ, Maynard J, Kim MR, Tamanoi F, Cooper DN. Mutational and functional analysis of the neurofibromatosis type 1 (NF1) gene. Human Genetics. 99: 88-92. PMID 9003501 DOI: 10.1007/S004390050317  0.337
1997 Del Villar K, Mitsuzawa H, Yang W, Sattler I, Tamanoi F. Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I. The Journal of Biological Chemistry. 272: 680-7. PMID 8995312 DOI: 10.1074/Jbc.272.1.680  0.536
1997 Del Villar K, Dorin D, Sattler I, Urano J, Poullet P, Robinson N, Mitsuzawa H, Tamanoi F. C-terminal motifs found in Ras-superfamily G-proteins: CAAX and C-seven motifs. Biochemical Society Transactions. 24: 709-13. PMID 8878831 DOI: 10.1042/Bst0240709  0.318
1996 Morcos P, Thapar N, Tusneem N, Stacey D, Tamanoi F. Identification of neurofibromin mutants that exhibit allele specificity or increased Ras affinity resulting in suppression of activated ras alleles. Molecular and Cellular Biology. 16: 2496-503. PMID 8628317 DOI: 10.1128/Mcb.16.5.2496  0.399
1996 Tamanoi F, Mitsuzawa H. Use of yeast for identification of farnesyltransferase inhibitors and for generation of mutant farnesyltransferases. Methods in Enzymology. 255: 82-91. PMID 8524140 DOI: 10.1016/S0076-6879(95)55011-9  0.315
1995 Poullet P, Tamanoi F. [49] Use of yeast two-hybrid system to evaluate ras interactions with neurofibromin-GTPase-activating protein Methods in Enzymology. 255: 488-497. PMID 8524136 DOI: 10.1016/S0076-6879(95)55051-8  0.347
1995 Mitsuzawa H, Esson K, Tamanoi F. Mutant farnesyltransferase beta subunit of Saccharomyces cerevisiae that can substitute for geranylgeranyltransferase type I beta subunit. Proceedings of the National Academy of Sciences of the United States of America. 92: 1704-8. PMID 7878044 DOI: 10.1073/Pnas.92.5.1704  0.351
1995 Gelb MH, Tamanoi F, Yokoyama K, Ghomashchi F, Esson K, Gould MN. The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol. Cancer Letters. 91: 169-75. PMID 7767906 DOI: 10.1016/0304-3835(95)03747-K  0.364
1995 Mitsuzawa H, Tamanoi F. In vivo assays for farnesyltransferase inhibitors with Saccharomyces cerevisiae. Methods in Enzymology. 250: 43-51. PMID 7651169 DOI: 10.1016/0076-6879(95)50061-8  0.412
1995 Baba H, Fuss B, Urano J, Poullet P, Watson JB, Tamanoi F, Macklin WB. GapIII, a new brain-enriched member of the GTPase-activating protein family. Journal of Neuroscience Research. 41: 846-58. PMID 7500386 DOI: 10.1002/Jnr.490410615  0.388
1994 Poullet P, Lin B, Esson K, Tamanoi F. Functional significance of lysine 1423 of neurofibromin and characterization of a second site suppressor which rescues mutations at this residue and suppresses RAS2Val-19-activated phenotypes. Molecular and Cellular Biology. 14: 815-21. PMID 8264648 DOI: 10.1128/Mcb.14.1.815  0.446
1994 Cohen L, Mohr R, Chen YY, Huang M, Kato R, Dorin D, Tamanoi F, Goga A, Afar D, Rosenberg N. Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases. Proceedings of the National Academy of Sciences of the United States of America. 91: 12448-52. PMID 7809057 DOI: 10.1073/Pnas.91.26.12448  0.377
1993 Hara M, Akasaka K, Akinaga S, Okabe M, Nakano H, Gomez R, Wood D, Uh M, Tamanoi F. Identification of Ras farnesyltransferase inhibitors by microbial screening. Proceedings of the National Academy of Sciences of the United States of America. 90: 2281-5. PMID 8460134 DOI: 10.1073/Pnas.90.6.2281  0.336
1993 Gomez R, Goodman LE, Tripathy SK, O'Rourke E, Manne V, Tamanoi F. Purified yeast protein farnesyltransferase is structurally and functionally similar to its mammalian counterpart. The Biochemical Journal. 289: 25-31. PMID 8424764 DOI: 10.1042/Bj2890025  0.346
1993 Tamanoi F. Inhibitors of Ras farnesyltransferases. Trends in Biochemical Sciences. 18: 349-53. PMID 8236454 DOI: 10.1016/0968-0004(93)90072-U  0.358
1992 McNeel DG, Tamanoi F. Terminal region recognition factor 1, a DNA-binding protein recognizing the inverted terminal repeats of the pGKl linear DNA plasmids. Proceedings of the National Academy of Sciences of the United States of America. 88: 11398-402. PMID 1763054 DOI: 10.1073/Pnas.88.24.11398  0.317
1992 Tanaka K, Wood DR, Lin BK, Khalil M, Tamanoi F, Cannon JF. A dominant activating mutation in the effector region of RAS abolishes IRA2 sensitivity. Molecular and Cellular Biology. 12: 631-7. PMID 1732735 DOI: 10.1128/Mcb.12.2.631  0.417
1991 Finegold AA, Johnson DI, Farnsworth CC, Gelb MH, Judd SR, Glomset JA, Tamanoi F. Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product Proceedings of the National Academy of Sciences of the United States of America. 88: 4448-4452. PMID 2034682 DOI: 10.1073/Pnas.88.10.4448  0.374
1991 Tanaka K, Lin BK, Wood DR, Tamanoi F. IRA2, an upstream negative regulator of RAS in yeast, is a RAS GTPase-activating protein Proceedings of the National Academy of Sciences of the United States of America. 88: 468-472. PMID 1988946 DOI: 10.1073/Pnas.88.2.468  0.434
1991 Golubić M, Tanaka K, Dobrowolski S, Wood D, Tsai M, Marshall M, Tamanoi F, Stacey D. The GTPase stimulatory activities of the neurofibromatosis type 1 and the yeast IRA2 proteins are inhibited by arachidonic acid. The Embo Journal. 10: 2897-2903. DOI: 10.1002/J.1460-2075.1991.Tb07839.X  0.426
1990 Tanaka K, Nakafuku M, Tamanoi F, Kaziro Y, Matsumoto K, Toh-e A. IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein. Molecular and Cellular Biology. 10: 4303-13. PMID 2164637 DOI: 10.1128/Mcb.10.8.4303  0.413
1990 Goodman LE, Judd SR, Farnsworth CC, Powers S, Gelb MH, Glomset JA, Tamanoi F. Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins. Proceedings of the National Academy of Sciences of the United States of America. 87: 9665-9. PMID 2124698 DOI: 10.1073/Pnas.87.24.9665  0.429
1990 Xu GF, Lin B, Tanaka K, Dunn D, Wood D, Gesteland R, White R, Weiss R, Tamanoi F. The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell. 63: 835-41. PMID 2121369 DOI: 10.1016/0092-8674(90)90149-9  0.41
1990 Finegold AA, Schafer WR, Rine J, Whiteway M, Tamanoi F. Common modifications of trimeric G proteins and ras protein: involvement of polyisoprenylation. Science (New York, N.Y.). 249: 165-9. PMID 1695391 DOI: 10.1126/Science.1695391  0.444
1990 Judd SR, Tamanoi F. A genetic approach to the study of farnesylation Methods. 1: 246-252. DOI: 10.1016/S1046-2023(05)80324-X  0.376
1989 Goodman LE, Perou CM, Fujiyama A, Tamanoi F. Structure and expression of yeast DPR1, a gene essential for the processing and intracellular localization of ras proteins. Yeast (Chichester, England). 4: 271-81. PMID 3064491 DOI: 10.1002/Yea.320040405  0.421
1989 Cobitz AR, Yim EH, Brown WR, Perou CM, Tamanoi F. Phosphorylation of RAS1 and RAS2 proteins in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 86: 858-62. PMID 2492665 DOI: 10.1073/Pnas.86.3.858  0.354
1988 Tamanoi F, Hsueh EC, Goodman LE, Cobitz AR, Detrick RJ, Brown WR, Fujiyama A. Posttranslational modification of ras proteins: detection of a modification prior to fatty acid acylation and cloning of a gene responsible for the modification. Journal of Cellular Biochemistry. 36: 261-73. PMID 3288644 DOI: 10.1002/Jcb.240360307  0.382
1987 Fujiyama A, Matsumoto K, Tamanoi F. A novel yeast mutant defective in the processing of ras proteins: assessment of the effect of the mutation on processing steps. The Embo Journal. 6: 223-228. DOI: 10.1002/J.1460-2075.1987.Tb04742.X  0.451
1985 Broek D, Samiy N, Fasano O, Fujiyama A, Tamanoi F, Northup J, Wigler M. Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins. Cell. 41: 763-9. PMID 3891097 DOI: 10.1016/S0092-8674(85)80057-X  0.399
1984 Tamanoi F, Walsh M, Kataoka T, Wigler M. A product of yeast RAS2 gene is a guanine nucleotide binding protein. Proceedings of the National Academy of Sciences of the United States of America. 81: 6924-8. PMID 6438624 DOI: 10.1073/Pnas.81.22.6924  0.385
1984 Fasano O, Aldrich T, Tamanoi F, Taparowsky E, Furth M, Wigler M. Analysis of the transforming potential of the human H-ras gene by random mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 81: 4008-12. PMID 6330729 DOI: 10.1073/Pnas.81.13.4008  0.379
1984 Hughes S, Mellstrom K, Kosik E, Tamanoi F, Brugge J. Mutation of a termination codon affects src initiation. Molecular and Cellular Biology. 4: 1738-46. PMID 6092936 DOI: 10.1128/Mcb.4.9.1738  0.35
1982 Stillman BW, Tamanoi F, Mathews MB. Purification of an adenovirus-coded DNA polymerase that is required for initiation of DNA replication. Cell. 31: 613-23. PMID 6297776 DOI: 10.1016/0092-8674(82)90317-8  0.339
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