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Xiaodong Cheng - Publications

Affiliations: 
Emory University, Atlanta, GA 
Area:
Biochemistry
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223 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Hardikar S, Ren R, Ying Z, Zhou J, Horton JR, Bramble MD, Liu B, Lu Y, Liu B, Coletta LD, Shen J, Dan J, Zhang X, Cheng X, Chen T. The ICF syndrome protein CDCA7 harbors a unique DNA binding domain that recognizes a CpG dyad in the context of a non-B DNA. Science Advances. 10: eadr0036. PMID 39178265 DOI: 10.1126/sciadv.adr0036  0.426
2024 Zhang X, Blumenthal RM, Cheng X. Keep Fingers on the CpG Islands. Epigenomes. 8. PMID 38920624 DOI: 10.3390/epigenomes8020023  0.414
2024 Zhang X, Blumenthal RM, Cheng X. Updated understanding of the protein-DNA recognition code used by C2H2 zinc finger proteins. Current Opinion in Structural Biology. 87: 102836. PMID 38754172 DOI: 10.1016/j.sbi.2024.102836  0.325
2024 Zhou J, Chen Q, Ren R, Yang J, Liu B, Horton JR, Chang C, Li C, Maksoud L, Yang Y, Rotili D, Zhang X, Blumenthal RM, Chen T, Gao Y, ... ... Cheng X, et al. Quinoline-based compounds can inhibit diverse enzymes that act on DNA. Biorxiv : the Preprint Server For Biology. PMID 38617249 DOI: 10.1101/2024.04.03.587980  0.385
2024 Zhou J, Chen T, Cheng X. One form and two functions: MBD of SETDB2 is a protein-interacting domain. Structure (London, England : 1993). 32: 258-260. PMID 38458157 DOI: 10.1016/j.str.2024.01.009  0.35
2023 Hardikar S, Ren R, Ying Z, Horton JR, Bramble MD, Liu B, Lu Y, Liu B, Dan J, Zhang X, Cheng X, Chen T. The ICF syndrome protein CDCA7 harbors a unique DNA-binding domain that recognizes a CpG dyad in the context of a non-B DNA. Biorxiv : the Preprint Server For Biology. PMID 38168392 DOI: 10.1101/2023.12.15.571946  0.427
2023 Zhang X, Xia F, Zhang X, Blumenthal RM, Cheng X. C2H2 zinc finger transcription factors associated with hemoglobinopathies. Journal of Molecular Biology. 168343. PMID 37924864 DOI: 10.1016/j.jmb.2023.168343  0.34
2023 Hong T, Li J, Guo L, Cavalier M, Wang T, Dou Y, DeLaFuente A, Fang S, Guzman A, Wohlan K, Kapadia C, Rosas C, Yang Y, Yin CC, Li S, ... ... Cheng X, et al. TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells. Nature Aging. PMID 37884767 DOI: 10.1038/s43587-023-00505-y  0.308
2023 Yang J, Horton JR, Liu B, Corces VG, Blumenthal RM, Zhang X, Cheng X. Structures of CTCF-DNA complexes including all 11 zinc fingers. Nucleic Acids Research. PMID 37439339 DOI: 10.1093/nar/gkad594  0.411
2023 Zhou J, Horton JR, Kaur G, Chen Q, Li X, Mendoza F, Wu T, Blumenthal RM, Zhang X, Cheng X. Biochemical and structural characterization of the first-discovered metazoan DNA cytosine-N4 methyltransferase from the Bdelloid rotifer Adineta vaga. The Journal of Biological Chemistry. 105017. PMID 37414145 DOI: 10.1016/j.jbc.2023.105017  0.434
2023 Chen Q, Liu B, Zeng Y, Hwang JW, Dai N, Corrêa IR, Estecio MR, Zhang X, Santos MA, Chen T, Cheng X. GSK-3484862 targets DNMT1 for degradation in cells. Nar Cancer. 5: zcad022. PMID 37206360 DOI: 10.1093/narcan/zcad022  0.356
2023 Zhou J, Deng Y, Iyamu ID, Horton JR, Yu D, Hajian T, Vedadi M, Rotili D, Mai A, Blumenthal RM, Zhang X, Huang R, Cheng X. Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Specific DNA Adenine Methyltransferase. Acs Chemical Biology. 18: 734-745. PMID 37082867 DOI: 10.1021/acschembio.3c00035  0.312
2023 Kaur G, Ren R, Hammel M, Horton JR, Yang J, Cao Y, He C, Lan F, Lan X, Blobel GA, Blumenthal RM, Zhang X, Cheng X. Allosteric autoregulation of DNA binding via a DNA-mimicking protein domain: a biophysical study of ZNF410-DNA interaction using small angle X-ray scattering. Nucleic Acids Research. PMID 36660822 DOI: 10.1093/nar/gkac1274  0.396
2023 Ren R, Horton JR, Chen Q, Yang J, Liu B, Huang Y, Blumenthal RM, Zhang X, Cheng X. Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia. The Journal of Biological Chemistry. 102885. PMID 36626981 DOI: 10.1016/j.jbc.2023.102885  0.366
2022 Horton JR, Zhou J, Chen Q, Zhang X, Bedford MT, Cheng X. A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2. The Journal of Biological Chemistry. 102862. PMID 36596360 DOI: 10.1016/j.jbc.2022.102862  0.316
2022 Zhou J, Horton JR, Menna M, Fiorentino F, Ren R, Yu D, Hajian T, Vedadi M, Mazzoccanti G, Ciogli A, Weinhold E, Hüben M, Blumenthal RM, Zhang X, Mai A, ... ... Cheng X, et al. Systematic Design of Adenosine Analogs as Inhibitors of a Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence. Journal of Medicinal Chemistry. PMID 36581322 DOI: 10.1021/acs.jmedchem.2c01789  0.347
2022 Ren R, Horton JR, Hong S, Cheng X. Recent Advances on DNA Base Flipping: A General Mechanism for Writing, Reading, and Erasing DNA Modifications. Advances in Experimental Medicine and Biology. 1389: 295-315. PMID 36350515 DOI: 10.1007/978-3-031-11454-0_12  0.424
2022 Cheng X, Blumenthal RM. Mediating and maintaining methylation while minimizing mutation: Recent advances on mammalian DNA methyltransferases. Current Opinion in Structural Biology. 75: 102433. PMID 35914495 DOI: 10.1016/j.sbi.2022.102433  0.342
2022 Yu D, Zhou J, Chen Q, Wu T, Blumenthal RM, Zhang X, Cheng X. Enzymatic Characterization of In Vitro Activity of RNA Methyltransferase PCIF1 on DNA. Biochemistry. PMID 35605980 DOI: 10.1021/acs.biochem.2c00134  0.333
2022 Horton JR, Pathuri S, Wong K, Ren R, Rueda L, Fosbenner DT, Heerding DA, McCabe MT, Pappalardi MB, Zhang X, King BW, Cheng X. Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure (London, England : 1993). PMID 35395178 DOI: 10.1016/j.str.2022.03.009  0.418
2021 Pappalardi MB, Keenan K, Cockerill M, Kellner WA, Stowell A, Sherk C, Wong K, Pathuri S, Briand J, Steidel M, Chapman P, Groy A, Wiseman AK, McHugh CF, Campobasso N, ... ... Cheng X, et al. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nature Cancer. 2: 1002-1017. PMID 34790902  0.374
2021 Yang Y, Ren R, Ly LC, Horton JR, Li F, Quinlan KGR, Crossley M, Shi Y, Cheng X. Structural basis for human ZBTB7A action at the fetal globin promoter. Cell Reports. 36: 109759. PMID 34592153 DOI: 10.1016/j.celrep.2021.109759  0.328
2021 Zhou J, Horton JR, Yu D, Ren R, Blumenthal RM, Zhang X, Cheng X. Repurposing epigenetic inhibitors to target the specific DNA adenine methyltransferase and sporulation regulator CamA. Epigenetics. 1-12. PMID 34523387 DOI: 10.1080/15592294.2021.1976910  0.372
2021 Zhou J, Horton JR, Blumenthal RM, Zhang X, Cheng X. Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix. Nature Communications. 12: 3436. PMID 34103525 DOI: 10.1038/s41467-021-23693-w  0.409
2021 Yu D, Horton JR, Yang J, Hajian T, Vedadi M, Sagum CA, Bedford MT, Blumenthal RM, Zhang X, Cheng X. Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions. Nucleic Acids Research. PMID 34086966 DOI: 10.1093/nar/gkab460  0.402
2021 Ichino L, Boone BA, Strauskulage L, Harris CJ, Kaur G, Gladstone MA, Tan M, Feng S, Jami-Alahmadi Y, Duttke SH, Wohlschlegel JA, Cheng X, Redding S, Jacobsen SE. MBD5 and MBD6 couple DNA methylation to gene silencing through the J-domain protein SILENZIO. Science (New York, N.Y.). PMID 34083448 DOI: 10.1126/science.abg6130  0.401
2021 Chen J, Horton J, Sagum C, Zhou J, Cheng X, Bedford MT. Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions. The Biochemical Journal. PMID 33969871 DOI: 10.1042/BCJ20210203  0.343
2020 Zeng Y, Ren R, Kaur G, Hardikar S, Ying Z, Babcock L, Gupta E, Zhang X, Chen T, Cheng X. The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation. Genes & Development. PMID 33004415 DOI: 10.1101/gad.341925.120  0.374
2020 Kumar J, Kaur G, Ren R, Lu Y, Lin K, Li J, Huang Y, Patel A, Barton MC, Macfarlan T, Zhang X, Cheng X. KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells. Nar Cancer. 2: zcaa007. PMID 32743551 DOI: 10.1093/narcan/zcaa007  0.313
2020 Woodcock CB, Horton JR, Zhou J, Bedford MT, Blumenthal RM, Zhang X, Cheng X. Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA. Nucleic Acids Research. PMID 32663306 DOI: 10.1093/Nar/Gkaa604  0.524
2020 Dai S, Holt MV, Horton JR, Woodcock CB, Patel A, Zhang X, Young NL, Wilkinson AW, Cheng X. Characterization of SETD3 methyltransferase mediated protein methionine methylation. The Journal of Biological Chemistry. PMID 32503840 DOI: 10.1074/Jbc.Ra120.014072  0.466
2020 Woodcock CB, Horton JR, Zhang X, Blumenthal RM, Cheng X. Beta class amino methyltransferases from bacteria to humans: evolution and structural consequences. Nucleic Acids Research. PMID 32453412 DOI: 10.1093/Nar/Gkaa446  0.465
2020 Mahgoub M, Paiano J, Bruno M, Wu W, Pathuri S, Zhang X, Ralls S, Cheng X, Nussenzweig A, Macfarlan TS. Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice. Elife. 9. PMID 32352380 DOI: 10.7554/Elife.53360  0.511
2020 Hardikar S, Ying Z, Zeng Y, Zhao H, Liu B, Veland N, McBride K, Cheng X, Chen T. The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation. Protein & Cell. PMID 31970665 DOI: 10.1007/s13238-019-00682-w  0.378
2020 Dai S, Horton JR, Wilkinson AW, Gozani O, Zhang X, Cheng X. An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation. The Journal of Biological Chemistry. PMID 31911441 DOI: 10.1074/Jbc.Ra119.012319  0.437
2020 Mahgoub M, Paiano J, Bruno M, Wu W, Pathuri S, Zhang X, Ralls S, Cheng X, Nussenzweig A, Macfarlan TS. Author response: Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice Elife. DOI: 10.7554/Elife.53360.Sa2  0.371
2019 Woodcock CB, Yu D, Hajian T, Li J, Huang Y, Dai N, Corrêa IR, Wu T, Vedadi M, Zhang X, Cheng X. Human MettL3-MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro. Cell Discovery. 5: 63. PMID 33353928 DOI: 10.1038/s41421-019-0136-4  0.34
2019 Woodcock CB, Yu D, Hajian T, Li J, Huang Y, Dai N, Corrêa IR, Wu T, Vedadi M, Zhang X, Cheng X. Human MettL3-MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro. Cell Discovery. 5: 63. PMID 31885874 DOI: 10.1038/S41421-019-0136-4  0.446
2019 Horton JR, Yang J, Zhang X, Petronzio T, Fomenkov A, Wilson GG, Roberts RJ, Cheng X. Structure of HhaI endonuclease with cognate DNA at an atomic resolution of 1.0 Å. Nucleic Acids Research. PMID 31879785 DOI: 10.1093/Nar/Gkz1195  0.488
2019 Wu X, Liu S, Sagum C, Chen J, Singh R, Chaturvedi A, Horton JR, Kashyap TR, Fushman D, Cheng X, Bedford MT, Wang B. Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne. Genes & Development. PMID 31699778 DOI: 10.1101/Gad.332395.119  0.472
2019 Woodcock CB, Yu D, Zhang X, Cheng X. Human HemK2/KMT9/N6AMT1 is an active protein methyltransferase, but does not act on DNA in vitro, in the presence of Trm112. Cell Discovery. 5: 50. PMID 31632689 DOI: 10.1038/S41421-019-0119-5  0.442
2019 Yang J, Zhang X, Blumenthal RM, Cheng X. JMB Special Issue on "Reading DNA and RNA methylation" Detection of DNA modifications by sequence-specific transcription factors. Journal of Molecular Biology. PMID 31626807 DOI: 10.1016/J.Jmb.2019.09.013  0.533
2019 Horton JR, Woodcock CB, Opot SB, Reich NO, Zhang X, Cheng X. The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site. Nature Communications. 10: 4600. PMID 31601797 DOI: 10.1038/S41467-019-12498-7  0.512
2019 Dai S, Horton JR, Woodcock CB, Wilkinson AW, Zhang X, Gozani O, Cheng X. Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nature Communications. 10: 3541. PMID 31388018 DOI: 10.1038/S41467-019-11554-6  0.367
2019 Ren R, Hardikar S, Horton JR, Lu Y, Zeng Y, Singh AK, Lin K, Coletta LD, Shen J, Lin Kong CS, Hashimoto H, Zhang X, Chen T, Cheng X. Structural basis of specific DNA binding by the transcription factor ZBTB24. Nucleic Acids Research. PMID 31226215 DOI: 10.2210/Pdb6Ml2/Pdb  0.469
2019 Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Research. PMID 31081034 DOI: 10.1093/nar/gkz381  0.492
2019 Milite C, Feoli A, Horton JR, Rescigno D, Cipriano A, Pisapia V, Viviano M, Pepe G, Amendola G, Novellino E, Cosconati S, Cheng X, Castellano S, Sbardella G. Discovery of a novel chemotype of histone lysine methyltransferase EHMT1/2 (GLP/G9a) inhibitors: rational design, synthesis, biological evaluation and co-crystal structure. Journal of Medicinal Chemistry. PMID 30753076 DOI: 10.1021/Acs.Jmedchem.8B02008  0.303
2019 Horton JR, Chen Q, Liu X, Woodcock CB, Zhang X, Cheng X. Effects of inhibition of the catalytic domain of histone lysine demethylase KDM5 Acta Crystallographica Section A. 75. DOI: 10.1107/S0108767319097885  0.364
2018 Wilkinson AW, Diep J, Dai S, Liu S, Ooi YS, Song D, Li TM, Horton JR, Zhang X, Liu C, Trivedi DV, Ruppel KM, Vilches-Moure JG, Casey KM, Mak J, ... ... Cheng X, et al. SETD3 is an actin histidine methyltransferase that prevents primary dystocia. Nature. PMID 30626964 DOI: 10.1038/S41586-018-0821-8  0.385
2018 Yang J, Horton JR, Wang D, Ren R, Li J, Sun D, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for effects of CpA modifications on C/EBPβ binding of DNA. Nucleic Acids Research. PMID 30566668 DOI: 10.1093/Nar/Gky1264  0.513
2018 Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Cyr M, Pohida K, Hu X, Shah P, ... ... Cheng X, et al. Structure-based engineering of irreversible inhibitors against histone lysine demethylase KDM5A. Journal of Medicinal Chemistry. PMID 30392349 DOI: 10.1021/Acs.Jmedchem.8B01219  0.399
2018 Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, ... ... Cheng X, et al. KDM5 histone demethylases repress immune response via suppression of STING. Plos Biology. 16: e2006134. PMID 30080846 DOI: 10.1371/Journal.Pbio.2006134  0.347
2018 Ren R, Horton JR, Zhang X, Blumenthal RM, Cheng X. Detecting and interpreting DNA methylation marks. Current Opinion in Structural Biology. 53: 88-99. PMID 30031306 DOI: 10.1016/J.Sbi.2018.06.004  0.504
2018 Patel A, Yang P, Tinkham M, Pradhan M, Sun MA, Wang Y, Hoang D, Wolf G, Horton JR, Zhang X, Macfarlan T, Cheng X. DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins. Cell. PMID 29551271 DOI: 10.1016/J.Cell.2018.02.058  0.462
2018 Horton JR, Liu X, Wu L, Zhang K, Shanks J, Zhang X, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Pohida K, Fang Y, Hu X, Jadhav A, ... ... Cheng X, et al. Insights into the action of inhibitor enantiomers against histone lysine demethylase 5A. Journal of Medicinal Chemistry. PMID 29537847 DOI: 10.1021/Acs.Jmedchem.8B00261  0.32
2017 Wang D, Horton JR, Zheng Y, Blumenthal RM, Zhang X, Cheng X. Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites. Nucleic Acids Research. PMID 29294058 DOI: 10.1093/Nar/Gkx1274  0.502
2017 Murray IA, Morgan RD, Luyten Y, Fomenkov A, Corrêa IR, Dai N, Allaw MB, Zhang X, Cheng X, Roberts RJ. The non-specific adenine DNA methyltransferase M.EcoGII. Nucleic Acids Research. PMID 29228259 DOI: 10.1093/Nar/Gkx1191  0.483
2017 Lee CC, Peng SH, Shen L, Lee CF, Du TH, Kang ML, Xu GL, Upadhyay AK, Cheng X, Yan YT, Zhang Y, Juan LJ. The Role of N-α-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting. Molecular Cell. PMID 28943313 DOI: 10.1016/J.Molcel.2017.08.025  0.462
2017 Patel A, Zhang X, Blumenthal RM, Cheng X. Structural basis of human PRDM9 allele C specific recognition of its cognate DNA sequence. The Journal of Biological Chemistry. PMID 28801461 DOI: 10.1074/Jbc.M117.805754  0.444
2017 Hashimoto H, Wang D, Horton JR, Zhang X, Corces VG, Cheng X. Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. Molecular Cell. PMID 28529057 DOI: 10.1016/J.Molcel.2017.05.004  0.467
2017 Head PE, Zhang H, Bastien AJ, Koyen AE, Withers AE, Daddacha WB, Cheng X, Yu DS. Sirtuin 2 mutations in human cancers impair its function in genome maintenance. The Journal of Biological Chemistry. PMID 28461331 DOI: 10.1074/Jbc.M116.772566  0.379
2017 Hong S, Wang D, Horton JR, Zhang X, Speck SH, Blumenthal RM, Cheng X. Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta. Nucleic Acids Research. PMID 28158710 DOI: 10.1093/Nar/Gkx057  0.444
2016 Wang D, Hashimoto H, Zhang X, Barwick BG, Lonial S, Boise LH, Vertino PM, Cheng X. MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma. Nucleic Acids Research. PMID 27903915 DOI: 10.1093/Nar/Gkw1184  0.461
2016 Hong S, Cheng X. DNA Base Flipping: A General Mechanism for Writing, Reading, and Erasing DNA Modifications. Advances in Experimental Medicine and Biology. 945: 321-341. PMID 27826845 DOI: 10.1007/978-3-319-43624-1_14  0.517
2016 Hashimoto H, Zhang X, Zheng Y, Wilson GG, Cheng X. Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications. Nucleic Acids Research. PMID 27596598 DOI: 10.1093/Nar/Gkw766  0.385
2016 Hashimoto H, Wang D, Steves AN, Jin P, Blumenthal RM, Zhang X, Cheng X. Distinctive Klf4 mutants determine preference for DNA methylation status. Nucleic Acids Research. PMID 27596594 DOI: 10.1093/Nar/Gkw774  0.504
2016 Horton JR, Liu X, Gale M, Wu L, Shanks JR, Zhang X, Webber PJ, Bell JS, Kales SC, Mott BT, Rai G, Jansen DJ, Henderson MJ, Urban DJ, Hall MD, ... ... Cheng X, et al. Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chemical Biology. PMID 27427228 DOI: 10.1016/J.Chembiol.2016.06.006  0.402
2016 Patel A, Horton JR, Wilson GG, Zhang X, Cheng X. Structural basis for human PRDM9 action at recombination hot spots. Genes & Development. 30: 257-65. PMID 26833727 DOI: 10.1101/Gad.274928.115  0.41
2015 Zeng Y, Yao B, Shin J, Lin L, Kim N, Song Q, Liu S, Su Y, Guo JU, Huang L, Wan J, Wu H, Qian J, Cheng X, Zhu H, et al. Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression. Molecular Cell. PMID 26711009 DOI: 10.1016/J.Molcel.2015.11.020  0.442
2015 Horton JR, Engstrom A, Zoeller EL, Liu X, Shanks JR, Zhang X, Johns MA, Vertino PM, Fu H, Cheng X. Characterization of a linked Jumonji domain of the KDM5/JARID1 family of histone H3 lysine 4 demethylases. The Journal of Biological Chemistry. PMID 26645689 DOI: 10.1074/Jbc.M115.698449  0.405
2015 Estève PO, Zhang G, Ponnaluri VK, Deepti K, Chin HG, Dai N, Sagum C, Black K, Corrêa IR, Bedford MT, Cheng X, Pradhan S. Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression. Nucleic Acids Research. PMID 26553800 DOI: 10.1093/Nar/Gkv1162  0.495
2015 Hashimoto H, Pais JE, Dai N, Corrêa IR, Zhang X, Zheng Y, Cheng X. Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA. Nucleic Acids Research. PMID 26323320 DOI: 10.1093/Nar/Gkv870  0.354
2015 Hashimoto H, Zhang X, Vertino PM, Cheng X. The Mechanisms of Generation, Recognition, and Erasure of DNA 5-Methylcytosine and Thymine Oxidations. The Journal of Biological Chemistry. 290: 20723-33. PMID 26152719 DOI: 10.1074/Jbc.R115.656884  0.484
2015 Liu ZQ, Zheng W, Huang JF, Jin LQ, Jia DX, Zhou HY, Xu JM, Liao CJ, Cheng XP, Mao BX, Zheng YG. Improvement and characterization of a hyperthermophilic glucose isomerase from Thermoanaerobacter ethanolicus and its application in production of high fructose corn syrup. Journal of Industrial Microbiology & Biotechnology. 42: 1091-103. PMID 26077737 DOI: 10.1007/S10295-015-1639-0  0.473
2015 Horton JR, Zhang X, Blumenthal RM, Cheng X. Structures of Escherichia coli DNA adenine methyltransferase (Dam) in complex with a non-GATC sequence: potential implications for methylation-independent transcriptional repression. Nucleic Acids Research. 43: 4296-308. PMID 25845600 DOI: 10.1093/Nar/Gkv251  0.482
2015 Pais JE, Dai N, Tamanaha E, Vaisvila R, Fomenkov AI, Bitinaite J, Sun Z, Guan S, Corrêa IR, Noren CJ, Cheng X, Roberts RJ, Zheng Y, Saleh L. Biochemical characterization of a Naegleria TET-like oxygenase and its application in single molecule sequencing of 5-methylcytosine. Proceedings of the National Academy of Sciences of the United States of America. 112: 4316-21. PMID 25831492 DOI: 10.1073/Pnas.1417939112  0.375
2015 Daugherty AB, Horton JR, Cheng X, Lutz S. STRUCTURAL AND FUNCTIONAL CONSEQUENCES OF CIRCULAR PERMUTATION ON THE ACTIVE SITE OF OLD YELLOW ENZYME. Acs Catalysis. 5: 892-899. PMID 25692074 DOI: 10.1021/Cs501702K  0.348
2015 Myrick LK, Hashimoto H, Cheng X, Warren ST. Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain. Human Molecular Genetics. 24: 1733-40. PMID 25416280 DOI: 10.1093/Hmg/Ddu586  0.408
2014 Horton JR, Wang H, Mabuchi MY, Zhang X, Roberts RJ, Zheng Y, Wilson GG, Cheng X. Modification-dependent restriction endonuclease, MspJI, flips 5-methylcytosine out of the DNA helix. Nucleic Acids Research. 42: 12092-101. PMID 25262349 DOI: 10.1093/Nar/Gku871  0.503
2014 Hashimoto H, Olanrewaju YO, Zheng Y, Wilson GG, Zhang X, Cheng X. Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. Genes & Development. 28: 2304-13. PMID 25258363 DOI: 10.1101/Gad.250746.114  0.466
2014 Hong S, Hashimoto H, Kow YW, Zhang X, Cheng X. The carboxy-terminal domain of ROS1 is essential for 5-methylcytosine DNA glycosylase activity. Journal of Molecular Biology. 426: 3703-12. PMID 25240767 DOI: 10.1016/J.Jmb.2014.09.010  0.42
2014 Cheng X. Structural and functional coordination of DNA and histone methylation. Cold Spring Harbor Perspectives in Biology. 6. PMID 25085914 DOI: 10.1101/Cshperspect.A018747  0.49
2014 Kao TH, Liao HF, Wolf D, Tai KY, Chuang CY, Lee HS, Kuo HC, Hata K, Zhang X, Cheng X, Goff SP, Ooi SK, Bestor TH, Lin SP. Ectopic DNMT3L triggers assembly of a repressive complex for retroviral silencing in somatic cells. Journal of Virology. 88: 10680-95. PMID 24991018 DOI: 10.1128/Jvi.01176-14  0.513
2014 Horton JR, Borgaro JG, Griggs RM, Quimby A, Guan S, Zhang X, Wilson GG, Zheng Y, Zhu Z, Cheng X. Structure of 5-hydroxymethylcytosine-specific restriction enzyme, AbaSI, in complex with DNA. Nucleic Acids Research. 42: 7947-59. PMID 24895434 DOI: 10.1093/Nar/Gku497  0.542
2014 Rotili D, Tarantino D, Marrocco B, Gros C, Masson V, Poughon V, Ausseil F, Chang Y, Labella D, Cosconati S, Di Maro S, Novellino E, Schnekenburger M, Grandjenette C, Bouvy C, ... ... Cheng X, et al. Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity. Plos One. 9: e96941. PMID 24810902 DOI: 10.1371/Journal.Pone.0096941  0.393
2014 Horton JR, Nugent RL, Li A, Mabuchi MY, Fomenkov A, Cohen-Karni D, Griggs RM, Zhang X, Wilson GG, Zheng Y, Xu SY, Cheng X. Structure and mutagenesis of the DNA modification-dependent restriction endonuclease AspBHI. Scientific Reports. 4: 4246. PMID 24604015 DOI: 10.1038/Srep04246  0.5
2014 Liu Y, Olanrewaju YO, Zheng Y, Hashimoto H, Blumenthal RM, Zhang X, Cheng X. Structural basis for Klf4 recognition of methylated DNA. Nucleic Acids Research. 42: 4859-67. PMID 24520114 DOI: 10.1093/Nar/Gku134  0.539
2014 Hashimoto H, Pais JE, Zhang X, Saleh L, Fu ZQ, Dai N, Corrêa IR, Zheng Y, Cheng X. Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA. Nature. 506: 391-5. PMID 24390346 DOI: 10.1038/Nature12905  0.507
2013 Liu Y, Olanrewaju YO, Zhang X, Cheng X. DNA recognition of 5-carboxylcytosine by a Zfp57 mutant at an atomic resolution of 0.97 Å. Biochemistry. 52: 9310-7. PMID 24236546 DOI: 10.1021/Bi401360N  0.519
2013 Cheng X, Blumenthal RM. Response to mackay et Al. Trends in Biochemical Sciences. 38: 423. PMID 23992946 DOI: 10.1016/J.Tibs.2013.06.010  0.462
2013 Hashimoto H, Zhang X, Cheng X. Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH. Dna Repair. 12: 535-40. PMID 23680598 DOI: 10.1016/J.Dnarep.2013.04.003  0.409
2013 Nicholson TB, Singh AK, Su H, Hevi S, Wang J, Bajko J, Li M, Valdez R, Goetschkes M, Capodieci P, Loureiro J, Cheng X, Li E, Kinzel B, Labow M, et al. A hypomorphic lsd1 allele results in heart development defects in mice. Plos One. 8: e60913. PMID 23637775 DOI: 10.1371/Journal.Pone.0060913  0.381
2013 Sun Z, Terragni J, Jolyon T, Borgaro JG, Liu Y, Yu L, Guan S, Wang H, Sun D, Cheng X, Zhu Z, Pradhan S, Zheng Y. High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells. Cell Reports. 3: 567-76. PMID 23352666 DOI: 10.1016/J.Celrep.2013.01.001  0.395
2013 Liu Y, Zhang X, Blumenthal RM, Cheng X. A common mode of recognition for methylated CpG. Trends in Biochemical Sciences. 38: 177-83. PMID 23352388 DOI: 10.1016/J.Tibs.2012.12.005  0.52
2013 Hashimoto H, Zhang X, Cheng X. Selective excision of 5-carboxylcytosine by a thymine DNA glycosylase mutant. Journal of Molecular Biology. 425: 971-6. PMID 23337108 DOI: 10.1016/J.Jmb.2013.01.013  0.415
2012 Liu Y, Toh H, Sasaki H, Zhang X, Cheng X. An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence. Genes & Development. 26: 2374-9. PMID 23059534 DOI: 10.1101/Gad.202200.112  0.52
2012 Hashimoto H, Hong S, Bhagwat AS, Zhang X, Cheng X. Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation. Nucleic Acids Research. 40: 10203-14. PMID 22962365 DOI: 10.1093/Nar/Gks845  0.493
2012 Horton JR, Mabuchi MY, Cohen-Karni D, Zhang X, Griggs RM, Samaranayake M, Roberts RJ, Zheng Y, Cheng X. Structure and cleavage activity of the tetrameric MspJI DNA modification-dependent restriction endonuclease. Nucleic Acids Research. 40: 9763-73. PMID 22848107 DOI: 10.1093/Nar/Gks719  0.503
2012 Hashimoto H, Zhang X, Cheng X. Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation. Nucleic Acids Research. 40: 8276-84. PMID 22740654 DOI: 10.1093/Nar/Gks628  0.512
2012 Hashimoto H, Liu Y, Upadhyay AK, Chang Y, Howerton SB, Vertino PM, Zhang X, Cheng X. Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation. Nucleic Acids Research. 40: 4841-9. PMID 22362737 DOI: 10.1093/Nar/Gks155  0.462
2012 Upadhyay AK, Rotili D, Han JW, Hu R, Chang Y, Labella D, Zhang X, Yoon YS, Mai A, Cheng X. An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases. Journal of Molecular Biology. 416: 319-27. PMID 22227394 DOI: 10.1016/J.Jmb.2011.12.036  0.343
2011 Nicholson TB, Su H, Hevi S, Wang J, Bajko J, Li M, Valdez R, Loureiro J, Cheng X, Li E, Kinzel B, Labow M, Chen T. Defective heart development in hypomorphic LSD1 mice. Cell Research. PMID 22143567 DOI: 10.1038/Cr.2011.194  0.387
2011 Chang Y, Sun L, Kokura K, Horton JR, Fukuda M, Espejo A, Izumi V, Koomen JM, Bedford MT, Zhang X, Shinkai Y, Fang J, Cheng X. MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nature Communications. 2: 533. PMID 22086334 DOI: 10.1038/Ncomms1549  0.459
2011 Szulwach KE, Li X, Li Y, Song CX, Wu H, Dai Q, Irier H, Upadhyay AK, Gearing M, Levey AI, Vasanthakumar A, Godley LA, Chang Q, Cheng X, He C, et al. 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nature Neuroscience. 14: 1607-16. PMID 22037496 DOI: 10.1038/Nn.2959  0.441
2011 Zhao J, Du Y, Horton JR, Upadhyay AK, Lou B, Bai Y, Zhang X, Du L, Li M, Wang B, Zhang L, Barbieri JT, Khuri FR, Cheng X, Fu H. Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 108: 16212-6. PMID 21908710 DOI: 10.1073/Pnas.1100012108  0.362
2011 Upadhyay AK, Horton JR, Zhang X, Cheng X. Coordinated methyl-lysine erasure: structural and functional linkage of a Jumonji demethylase domain and a reader domain. Current Opinion in Structural Biology. 21: 750-60. PMID 21872465 DOI: 10.1016/J.Sbi.2011.08.003  0.482
2011 Chang Y, Levy D, Horton JR, Peng J, Zhang X, Gozani O, Cheng X. Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling. Nucleic Acids Research. 39: 6380-9. PMID 21515635 DOI: 10.1093/Nar/Gkr256  0.441
2011 Cheng X, Blumenthal RM. Introduction--Epiphanies in epigenetics. Progress in Molecular Biology and Translational Science. 101: 1-21. PMID 21507348 DOI: 10.1016/B978-0-12-387685-0.00001-9  0.495
2011 Chang Y, Horton JR, Bedford MT, Zhang X, Cheng X. Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. Journal of Molecular Biology. 408: 807-14. PMID 21419134 DOI: 10.1016/J.Jmb.2011.03.018  0.451
2011 Horton JR, Upadhyay AK, Hashimoto H, Zhang X, Cheng X. Structural basis for human PHF2 Jumonji domain interaction with metal ions. Journal of Molecular Biology. 406: 1-8. PMID 21167174 DOI: 10.1016/J.Jmb.2010.12.013  0.388
2011 Estève PO, Chang Y, Samaranayake M, Upadhyay AK, Horton JR, Feehery GR, Cheng X, Pradhan S. A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability. Nature Structural & Molecular Biology. 18: 42-8. PMID 21151116 DOI: 10.1038/Nsmb.1939  0.428
2011 Upadhyay AK, Cheng X. Dynamics of histone lysine methylation: structures of methyl writers and erasers. Progress in Drug Research. Fortschritte Der Arzneimittelforschung. ProgrèS Des Recherches Pharmaceutiques. 67: 107-24. PMID 21141727 DOI: 10.1007/978-3-7643-8989-5_6  0.454
2011 Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P, Espejo A, Zee BM, Liu CL, Tangsombatvisit S, Tennen RI, Kuo AY, Tanjing S, Cheung R, Chua KF, ... ... Cheng X, et al. Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nature Immunology. 12: 29-36. PMID 21131967 DOI: 10.1038/Ni.1968  0.417
2010 Hashimoto H, Vertino PM, Cheng X. Molecular coupling of DNA methylation and histone methylation. Epigenomics. 2: 657-69. PMID 21339843 DOI: 10.2217/Epi.10.44  0.524
2010 Lee CF, Ou DS, Lee SB, Chang LH, Lin RK, Li YS, Upadhyay AK, Cheng X, Wang YC, Hsu HS, Hsiao M, Wu CW, Juan LJ. hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing. The Journal of Clinical Investigation. 120: 2920-30. PMID 20592467 DOI: 10.1172/Jci42275  0.385
2010 Chang Y, Ganesh T, Horton JR, Spannhoff A, Liu J, Sun A, Zhang X, Bedford MT, Shinkai Y, Snyder JP, Cheng X. Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. Journal of Molecular Biology. 400: 1-7. PMID 20434463 DOI: 10.1016/J.Jmb.2010.04.048  0.417
2010 Cheng X, Blumenthal RM. Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. Biochemistry. 49: 2999-3008. PMID 20210320 DOI: 10.1021/Bi100213T  0.493
2010 Collins R, Cheng X. A case study in cross-talk: the histone lysine methyltransferases G9a and GLP Nucleic Acids Research. 38: 3503-3511. PMID 20159995 DOI: 10.1093/Nar/Gkq081  0.43
2010 Horton JR, Upadhyay AK, Qi HH, Zhang X, Shi Y, Cheng X. Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nature Structural & Molecular Biology. 17: 38-43. PMID 20023638 DOI: 10.1038/Nsmb.1753  0.435
2009 Qian Z, Horton JR, Cheng X, Lutz S. Structural redesign of lipase B from Candida antarctica by circular permutation and incremental truncation. Journal of Molecular Biology. 393: 191-201. PMID 19683009 DOI: 10.1016/J.Jmb.2009.08.008  0.378
2009 Gao T, Collins RE, Horton JR, Zhang X, Zhang R, Dhayalan A, Tamas R, Jeltsch A, Cheng X. The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding. Proteins. 76: 772-7. PMID 19434754 DOI: 10.1002/Prot.22452  0.463
2009 Chang Y, Zhang X, Horton JR, Upadhyay AK, Spannhoff A, Liu J, Snyder JP, Bedford MT, Cheng X. Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nature Structural & Molecular Biology. 16: 312-7. PMID 19219047 DOI: 10.1038/Nsmb.1560  0.425
2009 Hashimoto H, Horton JR, Zhang X, Cheng X. UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications. Epigenetics : Official Journal of the Dna Methylation Society. 4: 8-14. PMID 19077538 DOI: 10.4161/Epi.4.1.7370  0.531
2009 Lee C, Ou DSC, Lee S, Chang L, Li Y, Jeng Y, Lee C, Hsu H, Lin R, Wang Y, Upadhyay A, Cheng X, Hsiao M, Wu C, Juan L. The Human Arrest-defective 1, A Putative Acetyltransferase, Downregulates Tumor Suppressor Gene Expression through Increasing DNA Methyltransferase 1 Activity Journal of Genetics and Molecular Biology. 20: 96-96. DOI: 10.30047/Jgmb.200912.0023  0.352
2008 Jurkowska RZ, Anspach N, Urbanke C, Jia D, Reinhardt R, Nellen W, Cheng X, Jeltsch A. Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. Nucleic Acids Research. 36: 6656-63. PMID 18945701 DOI: 10.1093/Nar/Gkn747  0.631
2008 Hashimoto H, Horton JR, Zhang X, Bostick M, Jacobsen SE, Cheng X. The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix. Nature. 455: 826-9. PMID 18772888 DOI: 10.1038/Nature07280  0.533
2008 Subramanian K, Jia D, Kapoor-Vazirani P, Powell DR, Collins RE, Sharma D, Peng J, Cheng X, Vertino PM. Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Molecular Cell. 30: 336-47. PMID 18471979 DOI: 10.1016/J.Molcel.2008.03.022  0.563
2008 Rathert P, Dhayalan A, Murakami M, Zhang X, Tamas R, Jurkowska R, Komatsu Y, Shinkai Y, Cheng X, Jeltsch A. Protein lysine methyltransferase G9a acts on non-histone targets Nature Chemical Biology. 4: 344-346. PMID 18438403 DOI: 10.1038/Nchembio.88  0.388
2008 Cheng X, Blumenthal RM. Mammalian DNA methyltransferases: a structural perspective. Structure (London, England : 1993). 16: 341-50. PMID 18334209 DOI: 10.1016/J.Str.2008.01.004  0.485
2008 Collins RE, Northrop JP, Horton JR, Lee DY, Zhang X, Stallcup MR, Cheng X. The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules. Nature Structural & Molecular Biology. 15: 245-50. PMID 18264113 DOI: 10.1038/Nsmb.1384  0.419
2008 Rathert P, Zhang X, Freund C, Cheng X, Jeltsch A. Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays. Chemistry & Biology. 15: 5-11. PMID 18215768 DOI: 10.1016/J.Chembiol.2007.11.013  0.39
2008 Dhayalan A, Jurkowski TP, Laser H, Reinhardt R, Jia D, Cheng X, Jeltsch A. Mapping of protein-protein interaction sites by the 'absence of interference' approach. Journal of Molecular Biology. 376: 1091-9. PMID 18191145 DOI: 10.1016/J.Jmb.2007.12.032  0.556
2008 Jeltsch A, Jurkowska R, Cheng X, Nellen W, Ansbach N, Ragozine S, Urbanke C, Jia D. Structure and mechanism of the Dnmt3a DNA methyltransferase Gbm Annual Spring Meeting Mosbach 2008. 2008. DOI: 10.1240/sav_gbm_2008_m_002160  0.582
2008 Jurkowska R, Jia D, Ragozin S, Ansbach N, Urbanke C, Zhang X, Reinhardt R, Nellen W, Cheng X, Jeltsch A. Multimerisation of the Dnmt3L-Dnmt3a complex on DNA and its mechanistic implications Gbm Annual Spring Meeting Mosbach 2008. 2008. DOI: 10.1240/sav_gbm_2008_m_002128  0.559
2007 Rathert P, Cheng X, Jeltsch A. Continuous enzymatic assay for histone lysine methyltransferases. Biotechniques. 43: 602-608. PMID 18072589 DOI: 10.2144/000112623  0.353
2007 Osborne TC, Obianyo O, Zhang X, Cheng X, Thompson PR. Protein arginine methyltransferase 1: positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis. Biochemistry. 46: 13370-81. PMID 17960915 DOI: 10.1021/Bi701558T  0.387
2007 Jia D, Jurkowska RZ, Zhang X, Jeltsch A, Cheng X. Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature. 449: 248-51. PMID 17713477 DOI: 10.1038/Nature06146  0.691
2007 Lan F, Collins RE, De Cegli R, Alpatov R, Horton JR, Shi X, Gozani O, Cheng X, Shi Y. Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature. 448: 718-22. PMID 17687328 DOI: 10.1038/Nature06034  0.442
2007 Ooi SK, Qiu C, Bernstein E, Li K, Jia D, Yang Z, Erdjument-Bromage H, Tempst P, Lin SP, Allis CD, Cheng X, Bestor TH. DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature. 448: 714-7. PMID 17687327 DOI: 10.1038/Nature05987  0.668
2007 Higashimoto K, Kuhn P, Desai D, Cheng X, Xu W. Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1. Proceedings of the National Academy of Sciences of the United States of America. 104: 12318-23. PMID 17640894 DOI: 10.1073/Pnas.0610792104  0.395
2007 Liebert K, Horton JR, Chahar S, Orwick M, Cheng X, Jeltsch A. Two alternative conformations of S-adenosyl-L-homocysteine bound to Escherichia coli DNA adenine methyltransferase and the implication of conformational changes in regulating the catalytic cycle. The Journal of Biological Chemistry. 282: 22848-55. PMID 17545164 DOI: 10.1074/Jbc.M700926200  0.461
2007 Lee DY, Ianculescu I, Purcell D, Zhang X, Cheng X, Stallcup MR. Surface-scanning mutational analysis of protein arginine methyltransferase 1: roles of specific amino acids in methyltransferase substrate specificity, oligomerization, and coactivator function. Molecular Endocrinology (Baltimore, Md.). 21: 1381-93. PMID 17426288 DOI: 10.1210/Me.2006-0389  0.432
2007 Horton JR, Elgar SJ, Khan SI, Zhang X, Wade PA, Cheng X. Structure of the SANT domain from the Xenopus chromatin remodeling factor ISWI. Proteins. 67: 1198-202. PMID 17377988 DOI: 10.1002/Prot.21352  0.476
2007 Cheng X, Zhang X. Structural dynamics of protein lysine methylation and demethylation. Mutation Research. 618: 102-115. PMID 17374386 DOI: 10.1016/J.Mrfmmm.2006.05.041  0.488
2007 Wu H, Horton JR, Battaile K, Allali-Hassani A, Martin F, Zeng H, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Cheng X. Structural basis of allele variation of human thiopurine-S-methyltransferase. Proteins. 67: 198-208. PMID 17243178 DOI: 10.1002/Prot.21272  0.377
2007 Jurkowska R, Jia D, Urbanke C, Cheng X, Jeltsch A. Multimerisation of the Dnmt3a-Dnmt3L complex on DNA and its mechanistic implications Gbm Fall Meeting Hamburg 2007. 2007. DOI: 10.1240/sav_gbm_2007_h_001845  0.559
2006 Zhang X, Cheng X. 4 Structure of protein arginine methyltransferases. The Enzymes. 24: 105-21. PMID 26718038 DOI: 10.1016/S1874-6047(06)80006-5  0.435
2006 Schubert HL, Blumenthal RM, Cheng X. 1 Protein Methyltransferases: Their Distribution Among the Five Structural Classes of AdoMet-Dependent Methyltransferases. The Enzymes. 24: 3-28. PMID 26718035 DOI: 10.1016/S1874-6047(06)80003-X  0.381
2006 Collins RE, Cheng X. Structural and biochemical advances in mammalian RNAi. Journal of Cellular Biochemistry. 99: 1251-66. PMID 16927374 DOI: 10.1002/Jcb.21069  0.37
2006 Mercante J, Suzuki K, Cheng X, Babitzke P, Romeo T. Comprehensive alanine-scanning mutagenesis of Escherichia coli CsrA defines two subdomains of critical functional importance. The Journal of Biological Chemistry. 281: 31832-42. PMID 16923806 DOI: 10.1074/Jbc.M606057200  0.345
2006 Reyes-Turcu FE, Horton JR, Mullally JE, Heroux A, Cheng X, Wilkinson KD. The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. Cell. 124: 1197-208. PMID 16564012 DOI: 10.1016/J.Cell.2006.02.038  0.378
2006 Horton JR, Liebert K, Bekes M, Jeltsch A, Cheng X. Structure and substrate recognition of the Escherichia coli DNA adenine methyltransferase. Journal of Molecular Biology. 358: 559-70. PMID 16524590 DOI: 10.1016/J.Jmb.2006.02.028  0.482
2006 Horton JR, Zhang X, Maunus R, Yang Z, Wilson GG, Roberts RJ, Cheng X. DNA nicking by HinP1I endonuclease: bending, base flipping and minor groove expansion. Nucleic Acids Research. 34: 939-48. PMID 16473850 DOI: 10.1093/Nar/Gkj484  0.466
2005 Horton JR, Sawada K, Nishibori M, Cheng X. Structural basis for inhibition of histamine N-methyltransferase by diverse drugs. Journal of Molecular Biology. 353: 334-44. PMID 16168438 DOI: 10.1016/J.Jmb.2005.08.040  0.329
2005 Collins RE, Cheng X. Structural domains in RNAi. Febs Letters. 579: 5841-9. PMID 16107250 DOI: 10.1016/J.Febslet.2005.07.072  0.3
2005 Dillon SC, Zhang X, Trievel RC, Cheng X. The SET-domain protein superfamily: protein lysine methyltransferases. Genome Biology. 6: 227. PMID 16086857 DOI: 10.1186/Gb-2005-6-8-227  0.427
2005 Gowher H, Zhang X, Cheng X, Jeltsch A. Avidin plate assay system for enzymatic characterization of a histone lysine methyltransferase. Analytical Biochemistry. 342: 287-91. PMID 15935324 DOI: 10.1016/J.Ab.2005.04.028  0.43
2005 Horton JR, Liebert K, Hattman S, Jeltsch A, Cheng X. Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase. Cell. 121: 349-61. PMID 15882618 DOI: 10.1016/J.Cell.2005.02.021  0.513
2005 Cheng X, Collins RE, Zhang X. Structural and sequence motifs of protein (histone) methylation enzymes. Annual Review of Biophysics and Biomolecular Structure. 34: 267-94. PMID 15869391 DOI: 10.1146/Annurev.Biophys.34.040204.144452  0.458
2005 Yang Z, Horton JR, Maunus R, Wilson GG, Roberts RJ, Cheng X. Structure of HinP1I endonuclease reveals a striking similarity to the monomeric restriction enzyme MspI. Nucleic Acids Research. 33: 1892-901. PMID 15805123 DOI: 10.1093/Nar/Gki337  0.503
2005 Collins RE, Tachibana M, Tamaru H, Smith KM, Jia D, Zhang X, Selker EU, Shinkai Y, Cheng X. In vitro and in vivo analyses of a Phe/Tyr switch controlling product specificity of histone lysine methyltransferases. The Journal of Biological Chemistry. 280: 5563-70. PMID 15590646 DOI: 10.1074/Jbc.M410483200  0.619
2005 Amor JC, Swails J, Zhu X, Roy CR, Nagai H, Ingmundson A, Cheng X, Kahn RA. The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site. The Journal of Biological Chemistry. 280: 1392-400. PMID 15520000 DOI: 10.1074/Jbc.M410820200  0.359
2004 Sawada K, Yang Z, Horton JR, Collins RE, Zhang X, Cheng X. Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase. The Journal of Biological Chemistry. 279: 43296-306. PMID 15292170 DOI: 10.1074/Jbc.M405902200  0.51
2004 Horton JR, Ratner G, Banavali NK, Huang N, Choi Y, Maier MA, Marquez VE, MacKerell AD, Cheng X. Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase. Nucleic Acids Research. 32: 3877-86. PMID 15273274 DOI: 10.1093/Nar/Gkh701  0.493
2004 Yang Z, Shipman L, Zhang M, Anton BP, Roberts RJ, Cheng X. Structural characterization and comparative phylogenetic analysis of Escherichia coli HemK, a protein (N5)-glutamine methyltransferase. Journal of Molecular Biology. 340: 695-706. PMID 15223314 DOI: 10.1016/J.Jmb.2004.05.019  0.454
2004 Dong A, Zhou L, Zhang X, Stickel S, Roberts RJ, Cheng X. Structure of the Q237W mutant of HhaI DNA methyltransferase: an insight into protein-protein interactions. Biological Chemistry. 385: 373-9. PMID 15195996 DOI: 10.1515/Bc.2004.041  0.498
2004 Jackson JP, Johnson L, Jasencakova Z, Zhang X, PerezBurgos L, Singh PB, Cheng X, Schubert I, Jenuwein T, Jacobsen SE. Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana. Chromosoma. 112: 308-15. PMID 15014946 DOI: 10.1007/S00412-004-0275-7  0.431
2003 Yang Z, Horton JR, Zhou L, Zhang XJ, Dong A, Zhang X, Schlagman SL, Kossykh V, Hattman S, Cheng X. Structure of the bacteriophage T4 DNA adenine methyltransferase. Nature Structural Biology. 10: 849-55. PMID 12937411 DOI: 10.1038/Nsb973  0.528
2003 Zhang X, Yang Z, Khan SI, Horton JR, Tamaru H, Selker EU, Cheng X. Structural basis for the product specificity of histone lysine methyltransferases. Molecular Cell. 12: 177-85. PMID 12887903 DOI: 10.1016/S1097-2765(03)00224-7  0.433
2003 Schubert HL, Blumenthal RM, Cheng X. Many paths to methyltransfer: a chronicle of convergence Trends in Biochemical Sciences. 28: 329-335. PMID 12826405 DOI: 10.1016/S0968-0004(03)00090-2  0.396
2003 Zhang X, Cheng X. Structure of the Predominant Protein Arginine Methyltransferase PRMT1 and Analysis of Its Binding to Substrate Peptides Structure. 11: 509-520. PMID 12737817 DOI: 10.1016/S0969-2126(03)00071-6  0.398
2003 Tamaru H, Zhang X, McMillen D, Singh PB, Nakayama J, Grewal SI, Allis CD, Cheng X, Selker EU. Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Nature Genetics. 34: 75-9. PMID 12679815 DOI: 10.1038/Ng1143  0.451
2003 Wu P, Qiu C, Sohail A, Zhang X, Bhagwat AS, Cheng X. Mismatch repair in methylated DNA. Structure and activity of the mismatch-specific thymine glycosylase domain of methyl-CpG-binding protein MBD4. The Journal of Biological Chemistry. 278: 5285-91. PMID 12456671 DOI: 10.1074/Jbc.M210884200  0.536
2002 Min J, Zhang X, Cheng X, Grewal SI, Xu RM. Structure of the SET domain histone lysine methyltransferase Clr4. Nature Structural Biology. 9: 828-32. PMID 12389037 DOI: 10.1038/Nsb860  0.467
2002 Zhang X, Tamaru H, Khan SI, Horton JR, Keefe LJ, Selker EU, Cheng X. Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase. Cell. 111: 117-27. PMID 12372305 DOI: 10.1016/S0092-8674(02)00999-6  0.452
2002 Whitehead SE, Jones KW, Zhang X, Cheng X, Terns RM, Terns MP. Determinants of the interaction of the spinal muscular atrophy disease protein SMN with the dimethylarginine-modified box H/ACA small nucleolar ribonucleoprotein GAR1. The Journal of Biological Chemistry. 277: 48087-93. PMID 12244096 DOI: 10.1074/Jbc.M204551200  0.33
2002 Zhou L, Cheng X, Connolly BA, Dickman MJ, Hurd PJ, Hornby DP. Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. Journal of Molecular Biology. 321: 591-9. PMID 12206775 DOI: 10.1016/S0022-2836(02)00676-9  0.41
2002 Lee YH, Koh SS, Zhang X, Cheng X, Stallcup MR. Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities. Molecular and Cellular Biology. 22: 3621-32. PMID 11997499 DOI: 10.1128/Mcb.22.11.3621-3632.2002  0.384
2002 Cheng X, Blumenthal RM. Cytosines Do It, Thymines Do It, Even Pseudouridines Do It—Base Flipping by an Enzyme that Acts on RNA Structure. 10: 127-129. PMID 11839295 DOI: 10.1016/S0969-2126(02)00710-4  0.363
2002 Qiu C, Sawada K, Zhang X, Cheng X. The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds Nature Structural & Molecular Biology. 9: 217-224. PMID 11836534 DOI: 10.1038/Nsb759  0.501
2002 Green DM, Marfatia KA, Crafton EB, Zhang X, Cheng X, Corbett AH. Nab2p is required for poly(A) RNA export in Saccharomyces cerevisiae and is regulated by arginine methylation via Hmt1p. The Journal of Biological Chemistry. 277: 7752-60. PMID 11779864 DOI: 10.1074/Jbc.M110053200  0.338
2002 Cheng X, Horton J, Khan S. A structural view of protein methylation Acta Crystallographica Section A. 58: 6-6. DOI: 10.1107/S010876730208532X  0.394
2001 Horton JR, Sawada K, Nishibori M, Zhang X, Cheng X. Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons. Structure (London, England : 1993). 9: 837-49. PMID 11566133 DOI: 10.1016/S0969-2126(01)00643-8  0.381
2001 Cheng X, Roberts RJ. AdoMet-dependent methylation, DNA methyltransferases and base flipping. Nucleic Acids Research. 29: 3784-95. PMID 11557810 DOI: 10.1093/Nar/29.18.3784  0.489
2001 Amor JC, Horton JR, Zhu X, Wang Y, Sullards C, Ringe D, Cheng X, Kahn RA. Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases. The Journal of Biological Chemistry. 276: 42477-84. PMID 11535602 DOI: 10.1074/Jbc.M106660200  0.354
2001 Blumenthal RM, Cheng X. A Taq attack displaces bases. Nature Structural & Molecular Biology. 8: 101-103. PMID 11175890 DOI: 10.1038/84072  0.495
2001 Dong A, Yoder JA, Zhang X, Zhou L, Bestor TH, Cheng X. Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA Nucleic Acids Research. 29: 439-448. PMID 11139614 DOI: 10.1093/Nar/29.2.439  0.503
2000 Vilkaitis G, Dong A, Weinhold E, Cheng X, Klimašauskas S. Functional roles of the conserved threonine 250 in the target recognition domain of HhaI DNA methyltransferase. Journal of Biological Chemistry. 275: 38722-38730. PMID 11102456 DOI: 10.1074/Jbc.M005278200  0.471
2000 Horton JR, Cheng X. PvuII endonuclease contains two calcium ions in active sites. Journal of Molecular Biology. 300: 1049-56. PMID 10903853 DOI: 10.1006/Jmbi.2000.3938  0.322
2000 Zhang X, Zhou L, Cheng X. Crystal structure of the conserved core of protein arginine methyltransferase PRMT3. The Embo Journal. 19: 3509-3519. PMID 10899106 DOI: 10.1093/Emboj/19.14.3509  0.449
1999 Liu Y, Gong W, Huang CC, Herr W, Cheng X. Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16. Genes & Development. 13: 1692-703. PMID 10398682 DOI: 10.1101/Gad.13.13.1692  0.409
1999 O'Gara M, Zhang X, Roberts RJ, Cheng X. Structure of a binary complex of HhaI methyltransferase with S-adenosyl-L-methionine formed in the presence of a short non-specific DNA oligonucleotide. Journal of Molecular Biology. 287: 201-9. PMID 10080885 DOI: 10.1006/Jmbi.1999.2608  0.43
1999 Sheikhnejad G, Brank A, Christman JK, Goddard A, Alvarez E, Ford H, Marquez VE, Marasco CJ, Sufrin JR, O'gara M, Cheng X. Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine. Journal of Molecular Biology. 285: 2021-34. PMID 9925782 DOI: 10.1006/Jmbi.1998.2426  0.482
1999 Horton JR, Bonventre J, Cheng X. How is modification of the DNA substrate recognized by the PvuII restriction endonuclease Journal of Biological Chemistry. 379: 451-458. DOI: 10.2210/Pdb2Pvi/Pdb  0.451
1998 Horton JR, Nastri HG, Riggs PD, Cheng X. Asp34 of PvuII endonuclease is directly involved in DNA minor groove recognition and indirectly involved in catalysis. Journal of Molecular Biology. 284: 1491-504. PMID 9878366 DOI: 10.1006/Jmbi.1998.2269  0.492
1998 O'Gara M, Horton JR, Roberts RJ, Cheng X. Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base. Nature Structural Biology. 5: 872-7. PMID 9783745 DOI: 10.1038/2312  0.429
1998 Horton JR, Bonventre J, Cheng X. How is modification of the DNA substrate recognized by the PvuII restriction endonuclease? Biological Chemistry. 379: 451-8. PMID 9628337 DOI: 10.1515/Bchm.1998.379.4-5.451  0.411
1997 Lloyd RS, Cheng X. Mechanistic link between DNA methyltransferases and DNA repair enzymes by base flipping. Biopolymers. 44: 139-151. PMID 9354758 DOI: 10.1002/(Sici)1097-0282(1997)44:2<139::Aid-Bip3>3.0.Co;2-W  0.477
1997 O'Gara M, Adams GM, Gong W, Kobayashi R, Blumenthal RM, Cheng X. Expression, purification, mass spectrometry, crystallization and multiwavelength anomalous diffraction of selenomethionyl PvuII DNA methyltransferase (cytosine-N4-specific). European Journal of Biochemistry / Febs. 247: 1009-18. PMID 9288926 DOI: 10.1111/J.1432-1033.1997.01009.X  0.378
1997 Kumar S, Horton JR, Jones GD, Walker RT, Roberts RJ, Cheng X. DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferase. Nucleic Acids Research. 25: 2773-83. PMID 9207024 DOI: 10.1093/Nar/25.14.2773  0.497
1997 Gong W, O'Gara M, Blumenthal RM, Cheng X. Structure of pvu II DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignment. Nucleic Acids Research. 25: 2702-15. PMID 9207015 DOI: 10.1093/Nar/25.14.2702  0.404
1997 Xu RM, Jokhan L, Cheng X, Mayeda A, Krainer AR. Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs. Structure (London, England : 1993). 5: 559-70. PMID 9115444 DOI: 10.1016/S0969-2126(97)00211-6  0.333
1997 Xu RM, Koch C, Liu Y, Horton JR, Knapp D, Nasmyth K, Cheng X. Crystal structure of the DNA-binding domain of Mbp1, a transcription factor important in cell-cycle control of DNA synthesis. Structure (London, England : 1993). 5: 349-58. PMID 9083114 DOI: 10.1016/S0969-2126(97)00192-5  0.475
1996 O'Gara M, Roberts RJ, Cheng X. A structural basis for the preferential binding of hemimethylated DNA by HhaI DNA methyltransferase. Journal of Molecular Biology. 263: 597-606. PMID 8918941 DOI: 10.1006/Jmbi.1996.0601  0.52
1996 Cheng X, Blumenthal RM. Finding a basis for flipping bases Structure. 4: 639-645. PMID 8805547 DOI: 10.1016/S0969-2126(96)00068-8  0.487
1996 O'Gara M, Klimasauskas S, Roberts RJ, Cheng X. Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes. Journal of Molecular Biology. 261: 634-45. PMID 8800212 DOI: 10.1006/Jmbi.1996.0489  0.457
1996 Xu RM, Carmel G, Kuret J, Cheng X. Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 93: 6308-13. PMID 8692811 DOI: 10.1073/Pnas.93.13.6308  0.304
1996 Cheng X. Enzymatic C5-cytosine methylation of DNA Acta Crystallographica Section A. 52: 95-95. DOI: 10.1107/S0108767396095293  0.457
1996 Xu R, Koch C, Nasmyth K, Cheng X. Crystal structure of the DNA-binding domain of MBP1, a transcription factor important in progression from G1 to S phase Acta Crystallographica Section a Foundations of Crystallography. 52: C160-C161. DOI: 10.1107/S0108767396092823  0.409
1995 Schluckebier G, O'Gara M, Saenger W, Cheng X. Universal catalytic domain structure of AdoMet-dependent methyltransferases. Journal of Molecular Biology. 247: 16-20. PMID 7897657 DOI: 10.1006/Jmbi.1994.0117  0.445
1995 Cheng X. DNA modification by methyltransferases Current Opinion in Structural Biology. 5: 4-10. PMID 7773746 DOI: 10.1016/0959-440X(95)80003-J  0.547
1995 Cheng X. Structure and function of DNA methyl transferases Annual Review of Biophysics and Biomolecular Structure. 24: 293-318. PMID 7663118 DOI: 10.1146/Annurev.Bb.24.060195.001453  0.541
1995 Cheng X, Balendiran K, Schildkraut I, Anderson JE. Crystal structure of the PvuII restriction endonuclease Gene. 157: 139-140. PMID 7607478 DOI: 10.1016/0378-1119(95)00670-2  0.358
1995 O'Gara M, McCloy K, Malone T, Cheng X. Structure-based sequence alignment of three AdoMet-dependent DNA methyltransferases. Gene. 157: 135-8. PMID 7607477 DOI: 10.1016/0378-1119(94)00669-J  0.457
1995 Malone T, Blumenthal RM, Cheng X. Structure-guided analysis reveals nine sequence motifs conserved among DNA amino-methyltransferases, and suggests a catalytic mechanism for these enzymes. Journal of Molecular Biology. 253: 618-32. PMID 7473738 DOI: 10.1006/Jmbi.1995.0577  0.427
1994 Klimasauskas S, Kumar S, Roberts RJ, Cheng X. Hhal methyltransferase flips its target base out of the DNA helix Cell. 76: 357-369. PMID 8293469 DOI: 10.1016/0092-8674(94)90342-5  0.527
1994 Cheng X, Zhang X, Pflugrath JW, Studier FW. The structure of bacteriophage T7 lysozyme, a zinc amidase and an inhibitor of T7 RNA polymerase. Proceedings of the National Academy of Sciences of the United States of America. 91: 4034-8. PMID 8171031 DOI: 10.1073/Pnas.91.9.4034  0.313
1994 Kumar S, Cheng X, Klimasauskas S, Mi S, Posfai J, Roberts RJ, Wilson GG. The DNA (cytosine-5) methyltransferases Nucleic Acids Research. 22: 1-10. PMID 8127644 DOI: 10.1093/Nar/22.1.1  0.441
1994 Cheng X, Kumar S, Klimasauskas S, Roberts RJ. Crystal structure of the HhaI DNA methyltransferase. Cold Spring Harbor Symposia On Quantitative Biology. 58: 331-8. PMID 7956046 DOI: 10.1101/Sqb.1993.058.01.039  0.501
1994 Cheng X, Balendiran K, Schildkraut I, Anderson JE. Structure of PvuII endonuclease with cognate DNA The Embo Journal. 13: 3927-3935. DOI: 10.1002/J.1460-2075.1994.Tb06708.X  0.481
1993 Cheng X, Kumar S, Posfai J, Pflugrath JW, Roberts RJ. Crystal-Structure of the Hhal DNA Methyltransferase Complexed with S-Adenosyl-L-Methionine Cell. 74: 299-307. PMID 8343957 DOI: 10.1016/0092-8674(93)90421-L  0.472
1993 Cheng X, Kumar S, Sha M, Roberts RJ. Crystal structure of HhaI DNA methyltransferase complexed with S-adenosyl-l-methionine Acta Crystallographica Section A. 49: 61-61. DOI: 10.1107/S0108767378098232  0.389
1992 Kumar S, Cheng X, Pflugrath JW, Roberts RJ. Purification, crystallization, and preliminary X-ray diffraction analysis of an M.HhaI-AdoMet complex. Biochemistry. 31: 8648-8653. PMID 1390649 DOI: 10.1021/Bi00151A035  0.357
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