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Donald J. Creighton - Publications

Affiliations: 
Biochemistry University of Maryland, Baltimore County, Baltimore, MD, United States 
Area:
Biochemistry, Pharmacology
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Sang Y, Shi Q, Mo M, Ni C, Li Z, Liu B, Deng Q, Creighton DJ, Zheng ZB. Novel bivalent inhibitors with sub-nanomolar affinities towards human glyoxalase I. Bioorganic & Medicinal Chemistry Letters. 25: 4724-7. PMID 26320622 DOI: 10.1016/J.Bmcl.2015.08.055  0.355
2014 Holewinski RJ, Creighton DJ. Inhibition by active site directed covalent modification of human glyoxalase I. Bioorganic & Medicinal Chemistry. 22: 3301-8. PMID 24856185 DOI: 10.1016/J.Bmc.2014.04.055  0.407
2005 Zheng ZB, Zhu G, Tak H, Joseph E, Eiseman JL, Creighton DJ. N-(2-hydroxypropyl)methacrylamide copolymers of a glutathione (GSH)-activated glyoxalase i inhibitor and DNA alkylating agent: synthesis, reaction kinetics with GSH, and in vitro antitumor activities. Bioconjugate Chemistry. 16: 598-607. PMID 15898727 DOI: 10.1021/Bc0499634  0.387
2005 Akoachere M, Iozef R, Rahlfs S, Deponte M, Mannervik B, Creighton DJ, Schirmer H, Becker K. Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts. Biological Chemistry. 386: 41-52. PMID 15843146 DOI: 10.1515/Bc.2005.006  0.371
2003 Hamilton DS, Zhang X, Ding Z, Hubatsch I, Mannervik B, Houk KN, Ganem B, Creighton DJ. Mechanism of the glutathione transferase-catalyzed conversion of antitumor 2-crotonyloxymethyl-2-cycloalkenones to GSH adducts. Journal of the American Chemical Society. 125: 15049-58. PMID 14653739 DOI: 10.1021/Ja030396P  0.393
2003 Zheng ZB, Creighton DJ. Bivalent transition-state analogue inhibitors of human glyoxalase I. Organic Letters. 5: 4855-8. PMID 14653691 DOI: 10.1021/Ol035917S  0.364
2003 Creighton DJ, Zheng ZB, Holewinski R, Hamilton DS, Eiseman JL. Glyoxalase I inhibitors in cancer chemotherapy Biochemical Society Transactions. 31: 1378-1382. PMID 14641067 DOI: 10.1042/Bst0311378  0.376
2003 Joseph E, Eiseman JL, Hamilton DS, Wang H, Tak H, Ding Z, Ganem B, Creighton DJ. Molecular basis of the antitumor activities of 2-crotonyloxymethyl-2-cycloalkenones. Journal of Medicinal Chemistry. 46: 194-6. PMID 12502374 DOI: 10.1021/Jm0203027  0.303
2002 Zhang Q, Ding Z, Creighton DJ, Ganem B, Fabris D. Alkylation of nucleic acids by the antitumor agent COMC. Organic Letters. 4: 1459-62. PMID 11975603 DOI: 10.1021/Ol025612Y  0.322
2002 Hamilton DS, Ding Z, Ganem B, Creighton DJ. Glutathionyl transferase catalyzed addition of glutathione to COMC: a new hypothesis for antitumor activity. Organic Letters. 4: 1209-12. PMID 11922820 DOI: 10.1021/Ol025650H  0.313
2001 Creighton DJ, Hamilton DS. Brief history of glyoxalase I and what we have learned about metal ion-dependent, enzyme-catalyzed isomerizations. Archives of Biochemistry and Biophysics. 387: 1-10. PMID 11368170 DOI: 10.1006/Abbi.2000.2253  0.415
2000 Kalsi A, Kavarana MJ, Lu T, Whalen DL, Hamilton DS, Creighton DJ. Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. Journal of Medicinal Chemistry. 43: 3981-6. PMID 11052803 DOI: 10.1021/Jm000160L  0.406
1999 Cameron AD, Ridderström M, Olin B, Kavarana MJ, Creighton DJ, Mannervik B. Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue. Biochemistry. 38: 13480-90. PMID 10521255 DOI: 10.1021/Bi990696C  0.387
1999 Hamilton DS, Kavarana MJ, Sharkey EM, Eiseman JL, Creighton DJ. A new method for rapidly generating inhibitors of glyoxalase I inside tumor cells using S-(N-aryl-N-hydroxycarbamoyl)ethylsulfoxides Journal of Medicinal Chemistry. 42: 1823-1827. PMID 10346934 DOI: 10.1021/Jm980712O  0.384
1999 Kavarana MJ, Kovaleva EG, Creighton DJ, Wollman MB, Eiseman JL. Mechanism-based competitive inhibitors of glyoxalase I: Intracellular delivery, in vitro antitumor activities, and stabilities in human serum and mouse serum Journal of Medicinal Chemistry. 42: 221-228. PMID 9925727 DOI: 10.1021/Jm9708036  0.348
1998 Saint-Jean AP, Phillips KR, Creighton DJ, Stone MJ. Active monomeric and dimeric forms of Pseudomonas putida glyoxalase I: evidence for 3D domain swapping. Biochemistry. 37: 10345-53. PMID 9671502 DOI: 10.1021/Bi980868Q  0.3
1997 Shih MJ, Edinger JW, Creighton DJ. Diffusion-dependent kinetic properties of glyoxalase I and estimates of the steady-state concentrations of glyoxalase-pathway intermediates in glycolyzing erythrocytes. European Journal of Biochemistry / Febs. 244: 852-7. PMID 9108256 DOI: 10.1111/J.1432-1033.1997.00852.X  0.372
1995 Lan Y, Lu T, Lovett PS, Creighton DJ. Evidence for a (triosephosphate isomerase-like) "catalytic loop" near the active site of glyoxalase I. The Journal of Biological Chemistry. 270: 12957-60. PMID 7768882 DOI: 10.1074/Jbc.270.22.12957  0.422
1994 Murthy NSRK, Bakeris T, Kavarana MJ, Hamilton DS, Lan Y, Creighton DJ. S-(N-Aryl-N-hydroxycarbamoyl)glutathione derivatives are tight-binding inhibitors of glyoxalase I and slow substrates for glyoxalase II Journal of Medicinal Chemistry. 37: 2161-2166. PMID 8035422 DOI: 10.1021/Jm00040A007  0.418
1994 Lu T, Creighton DJ, Antoine M, Fenselau C, Lovett PS. The gene encoding glyoxalase I from Pseudomonas putida: cloning, overexpression, and sequence comparisons with human glyoxalase I Gene. 150: 93-96. PMID 7959071 DOI: 10.1016/0378-1119(94)90864-8  0.304
1992 Hamilton DS, Creighton DJ. Caution: the glycylmethyl and glycylethyl esters of glutathione are substrates for glyoxalase I. Biochimica Et Biophysica Acta. 1159: 203-8. PMID 1390924 DOI: 10.1016/0167-4838(92)90026-A  0.391
1991 Xie X, Creighton DJ. Synthesis and initial characterization of γ-L-glutamyl-L-thiothreonyl-glycine and γ-L-glutamyl-L-allo-thiothreonylglycine as steric probes of the active site of glyoxalase I Biochemical and Biophysical Research Communications. 177: 252-258. PMID 2043110 DOI: 10.1016/0006-291X(91)91975-I  0.332
1991 Li J, Guha MK, Creighton DJ. Enzyme chemistry of dithiohemiacetals: synthesis and characterization of S-D-dithiomandeloylglutathione as an alternate substrate for glyoxalase I. Biochemical and Biophysical Research Communications. 181: 657-63. PMID 1755849 DOI: 10.1016/0006-291X(91)91241-4  0.382
1990 Creighton DJ, Murthy NSRK. 7 Stereochemistry of Enzyme -Catalyzed Reactions at Carbon Enzymes. 19: 323-421. DOI: 10.1016/S1874-6047(08)60200-0  0.369
1988 Creighton DJ, Migliorini M, Pourmotabbed T, Guha MK. Optimization of efficiency in the glyoxalase pathway. Biochemistry. 27: 7376-84. PMID 3207683 DOI: 10.1021/Bi00419A031  0.342
1986 Migliorini M, Creighton DJ. Active-site ionizations of papain. An evaluation of the potentiometric difference titration method European Journal of Biochemistry / Febs. 156: 189-192. PMID 3007141 DOI: 10.1111/J.1432-1033.1986.Tb09566.X  0.325
1983 Griffis CEF, Ong LH, Buettner L, Creighton DJ. Nonstereospecific substrate usage by glyoxalase I Biochemistry. 22: 2945-2951. PMID 6347254 DOI: 10.1021/Bi00281A025  0.375
1980 Welsh KM, Creighton DJ, Klinman JP. Transition-state structure in the yeast alcohol dehydrogenase reaction: the magnitude of solvent and alpha-secondary hydrogen isotope effects. Biochemistry. 19: 2005-16. PMID 6990968 DOI: 10.1021/Bi00551A001  0.314
1980 Creighton DJ, Weiner A, Buettner L. Hydrophobic binding is not an independent stereochemical determinant in the yeast glyoxalase I reaction Biophysical Chemistry. 11: 265-269. PMID 6989412 DOI: 10.1016/0301-4622(80)80029-9  0.382
1976 Creighton DJ, Hajdu J, Sigman DS. Model dehydrogenase reactions. Zinc ion catalyzed reduction of chelating aldehydes by N-propyl-1,4-dihydronicotinamides and borohydride Journal of the American Chemical Society. 98: 4619-4625. PMID 132467 DOI: 10.1021/Ja00431A047  0.383
1973 Creighton DJ. Model dehydrogenase reactions. Reduction of N-methylacridinium ion by reduced nicotinamide adenine dinucleotide and its derivatives [20] Journal of the American Chemical Society. 95: 6855-6857. PMID 4147716 DOI: 10.1021/Ja00801A067  0.367
1973 CREIGHTON DJ, HAJDU J, MOOSER G, SIGMAN DS. ChemInform Abstract: MODEL DEHYDROGENASE REACTIONS, REDUCTION OF N-METHYLACRIDINIUM ION BY REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE AND ITS DERIVATIVES Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197350164  0.367
1972 Sigman DS, Wahl GM, Creighton DJ. Models for metalloenzymes. Zinc ion catalyzed phosphorylation of 1,10-phenanthroline-2-carbinol by adenosine triphosphate Biochemistry. 11: 2236-2242. PMID 5028493 DOI: 10.1021/Bi00762A005  0.315
1971 Creighton DJ, Sigman DS. A model for alcohol dehydrogenase. The zinc ion catalyzed reduction of 1,10-phenanthroline-2-carboxaldehyde by N-propyl-1,4-dihydronicotinamide [36] Journal of the American Chemical Society. 93: 6314-6316. PMID 4256338 DOI: 10.1021/Ja00752A079  0.319
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