Michael Flagella, Ph.D. - Publications

Affiliations: 
2001 University of Cincinnati, Cincinnati, OH 
Area:
Animal Physiology Biology, Genetics, Molecular Biology

20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Gazzard L, Williams K, Chen H, Axford L, Blackwood E, Burton B, Chapman K, Crackett P, Drobnick J, Ellwood C, Epler J, Flagella M, Gancia E, Gill M, Goodacre S, et al. Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1. Journal of Medicinal Chemistry. 58: 5053-74. PMID 25988399 DOI: 10.1021/acs.jmedchem.5b00464  0.4
2015 Fuji RN, Flagella M, Baca M, Baptista MA, Brodbeck J, Chan BK, Fiske BK, Honigberg L, Jubb AM, Katavolos P, Lee DW, Lewin-Koh SC, Lin T, Liu X, Liu S, et al. Effect of selective LRRK2 kinase inhibition on nonhuman primate lung. Science Translational Medicine. 7: 273ra15. PMID 25653221 DOI: 10.1126/Scitranslmed.Aaa3634  0.4
2014 Estrada AA, Chan BK, Baker-Glenn C, Beresford A, Burdick DJ, Chambers M, Chen H, Dominguez SL, Dotson J, Drummond J, Flagella M, Fuji R, Gill A, Halladay J, Harris SF, et al. Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. Journal of Medicinal Chemistry. 57: 921-36. PMID 24354345 DOI: 10.1021/Jm401654J  0.4
2013 Blackwood E, Epler J, Yen I, Flagella M, O'Brien T, Evangelista M, Schmidt S, Xiao Y, Choi J, Kowanetz K, Ramiscal J, Wong K, Jakubiak D, Yee S, Cain G, et al. Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900. Molecular Cancer Therapeutics. 12: 1968-80. PMID 23873850 DOI: 10.1158/1535-7163.Mct-12-1218  0.4
2013 Safina BS, Sweeney ZK, Li J, Chan BK, Bisconte A, Carrera D, Castanedo G, Flagella M, Heald R, Lewis C, Murray JM, Nonomiya J, Pang J, Price S, Reif K, et al. Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity. Bioorganic & Medicinal Chemistry Letters. 23: 4953-9. PMID 23867164 DOI: 10.1016/J.Bmcl.2013.06.052  0.4
2012 Estrada AA, Liu X, Baker-Glenn C, Beresford A, Burdick DJ, Chambers M, Chan BK, Chen H, Ding X, DiPasquale AG, Dominguez SL, Dotson J, Drummond J, Flagella M, Flynn S, et al. Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. Journal of Medicinal Chemistry. 55: 9416-33. PMID 22985112 DOI: 10.1021/Jm301020Q  0.4
2012 Murray JM, Sweeney ZK, Chan BK, Balazs M, Bradley E, Castanedo G, Chabot C, Chantry D, Flagella M, Goldstein DM, Kondru R, Lesnick J, Li J, Lucas MC, Nonomiya J, et al. Potent and highly selective benzimidazole inhibitors of PI3-kinase delta. Journal of Medicinal Chemistry. 55: 7686-95. PMID 22877085 DOI: 10.1021/Jm300717C  0.4
2006 Flagella M, Bui S, Zheng Z, Nguyen CT, Zhang A, Pastor L, Ma Y, Yang W, Crawford KL, McMaster GK, Witney F, Luo Y. A multiplex branched DNA assay for parallel quantitative gene expression profiling. Analytical Biochemistry. 352: 50-60. PMID 16545767 DOI: 10.1016/j.ab.2006.02.013  0.4
2005 Zhang A, Pastor L, Nguyen Q, Luo Y, Yang W, Flagella M, Chavli R, Bui S, Nguyen CT, Zheng Z, He W, McMaster G, Witney F. Small interfering RNA and gene expression analysis using a multiplex branched DNA assay without RNA purification. Journal of Biomolecular Screening. 10: 549-56. PMID 16103413 DOI: 10.1177/1087057105277414  0.4
2004 Davidson JD, Ma L, Flagella M, Geeganage S, Gelbert LM, Slapak CA. An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines. Cancer Research. 64: 3761-6. PMID 15172981 DOI: 10.1158/0008-5472.CAN-03-3363  0.4
2002 Meyer JW, Flagella M, Sutliff RL, Lorenz JN, Nieman ML, Weber CS, Paul RJ, Shull GE. Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na(+)-K(+)-2Cl(-) cotransporter. American Journal of Physiology. Heart and Circulatory Physiology. 283: H1846-55. PMID 12384462 DOI: 10.1152/Ajpheart.00083.2002  0.4
2002 Miller ML, Judd LM, Van Driel IR, Andringa A, Flagella M, Bell SM, Schultheis PJ, Spicer Z, Shull GE. The unique ultrastructure of secretory membranes in gastric parietal cells depends upon the presence of H+, K+ -ATPase. Cell and Tissue Research. 309: 369-80. PMID 12195293 DOI: 10.1007/S00441-002-0606-Z  0.4
2002 Walker NM, Flagella M, Gawenis LR, Shull GE, Clarke LL. An alternate pathway of cAMP-stimulated Cl secretion across the NKCC1-null murine duodenum. Gastroenterology. 123: 531-41. PMID 12145806 DOI: 10.1053/Gast.2002.34757  0.4
2002 Shillingford JM, Miyoshi K, Flagella M, Shull GE, Hennighausen L. Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis. Molecular Endocrinology (Baltimore, Md.). 16: 1309-21. PMID 12040017 DOI: 10.1210/Mend.16.6.0857  0.4
2002 Su G, Kintner DB, Flagella M, Shull GE, Sun D. Astrocytes from Na(+)-K(+)-Cl(-) cotransporter-null mice exhibit absence of swelling and decrease in EAA release. American Journal of Physiology. Cell Physiology. 282: C1147-60. PMID 11940530 DOI: 10.1152/Ajpcell.00538.2001  0.4
2000 Evans RL, Park K, Turner RJ, Watson GE, Nguyen HV, Dennett MR, Hand AR, Flagella M, Shull GE, Melvin JE. Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice. The Journal of Biological Chemistry. 275: 26720-6. PMID 10831596 DOI: 10.1074/Jbc.M003753200  0.4
1999 Flagella M, Clarke LL, Miller ML, Erway LC, Giannella RA, Andringa A, Gawenis LR, Kramer J, Duffy JJ, Doetschman T, Lorenz JN, Yamoah EN, Cardell EL, Shull GE. Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf. The Journal of Biological Chemistry. 274: 26946-55. PMID 10480906 DOI: 10.1074/Jbc.274.38.26946  0.4
1998 Burnham CE, Flagella M, Wang Z, Amlal H, Shull GE, Soleimani M. Cloning, renal distribution, and regulation of the rat Na-[Formula: see text]cotransporter. American Journal of Physiology. Renal Physiology. 274: F1119-F1126. PMID 29586038 DOI: 10.1152/ajprenal.1998.274.6.F1119  0.4
1998 Burnham CE, Flagella M, Wang Z, Amlal H, Shull GE, Soleimani M. Cloning, renal distribution, and regulation of the rat Na+-HCO3- cotransporter. The American Journal of Physiology. 274: F1119-26. PMID 9841505 DOI: 10.1152/Ajprenal.1998.274.6.F1119  0.4
1998 Schultheis PJ, Lorenz JN, Meneton P, Nieman ML, Riddle TM, Flagella M, Duffy JJ, Doetschman T, Miller ML, Shull GE. Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule. The Journal of Biological Chemistry. 273: 29150-5. PMID 9786924 DOI: 10.1074/Jbc.273.44.29150  0.4
Show low-probability matches.