| Year |
Citation |
Score |
| 2024 |
Bonneux B, Shareef A, Tcherniuk S, Anson B, de Bruyn S, Verheyen N, Thys K, Conceição-Neto N, Van Ginderen M, Kwanten L, Ysebaert N, Vranckx L, Peeters E, Lanckacker E, Gallup JM, ... ... Fearns R, et al. JNJ-7184, a Respiratory Syncytial Virus inhibitor targeting the connector domain of the viral polymerase. Antiviral Research. 105907. PMID 38772503 DOI: 10.1016/j.antiviral.2024.105907 |
0.348 |
|
| 2023 |
Yu X, Abeywickrema P, Bonneux B, Behera I, Anson B, Jacoby E, Fung A, Adhikary S, Bhaumik A, Carbajo RJ, De Bruyn S, Miller R, Patrick A, Pham Q, Piassek M, ... ... Fearns R, et al. Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor. Communications Biology. 6: 1074. PMID 37865687 DOI: 10.1038/s42003-023-05451-4 |
0.514 |
|
| 2023 |
Kleiner VA, O Fischmann T, Howe JA, Beshore DC, Eddins MJ, Hou Y, Mayhood T, Klein D, Nahas DD, Lucas BJ, Xi H, Murray E, Ma DY, Getty K, Fearns R. Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases. Communications Biology. 6: 649. PMID 37337079 DOI: 10.1038/s42003-023-04990-0 |
0.579 |
|
| 2023 |
Ouizougun-Oubari M, Fearns R. Structures and Mechanisms of Nonsegmented, Negative-Strand RNA Virus Polymerases. Annual Review of Virology. PMID 37137281 DOI: 10.1146/annurev-virology-111821-102603 |
0.571 |
|
| 2022 |
Donovan-Banfield I, Milligan R, Hall S, Gao T, Murphy E, Li J, Shawli GT, Hiscox J, Zhuang X, McKeating JA, Fearns R, Matthews DA. Direct RNA sequencing of respiratory syncytial virus infected human cells generates a detailed overview of RSV polycistronic mRNA and transcript abundance. Plos One. 17: e0276697. PMID 36355791 DOI: 10.1371/journal.pone.0276697 |
0.552 |
|
| 2022 |
Cressey TN, Shareef AM, Kleiner VA, Noton SL, Byrne PO, McLellan JS, Muhlberger E, Fearns R. Distinctive features of the respiratory syncytial virus priming loop compared to other non-segmented negative strand rna viruses. Plos Pathogens. 18: e1010451. PMID 35731802 DOI: 10.1371/journal.ppat.1010451 |
0.636 |
|
| 2021 |
Conley MJ, Short JM, Burns AM, Streetley J, Hutchings J, Bakker SE, Power BJ, Jaffery H, Haney J, Zanetti G, Murcia PR, Stewart M, Fearns R, Vijayakrishnan S, Bhella D. Helical ordering of envelope-associated proteins and glycoproteins in respiratory syncytial virus. The Embo Journal. e109728. PMID 34935163 DOI: 10.15252/embj.2021109728 |
0.373 |
|
| 2021 |
Shareef AM, Ludeke B, Jordan P, Deval J, Fearns R. Comparison of RNA synthesis initiation properties of non-segmented negative strand RNA virus polymerases. Plos Pathogens. 17: e1010151. PMID 34914795 DOI: 10.1371/journal.ppat.1010151 |
0.659 |
|
| 2021 |
Braun MR, Noton SL, Blanchard EL, Shareef A, Santangelo PJ, Johnson WE, Fearns R. Respiratory syncytial virus M2-1 protein associates non-specifically with viral messenger RNA and with specific cellular messenger RNA transcripts. Plos Pathogens. 17: e1009589. PMID 34003848 DOI: 10.1371/journal.ppat.1009589 |
0.571 |
|
| 2021 |
Rhodin MHJ, McAllister NV, Castillo J, Noton SL, Fearns R, Kim IJ, Yu J, Blaisdell TP, Panarese J, Shook BC, Or YS, Goodwin B, Lin K. EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model. Plos Pathogens. 17: e1009428. PMID 33720995 DOI: 10.1371/journal.ppat.1009428 |
0.354 |
|
| 2020 |
Blanchard EL, Braun MR, Lifland AW, Ludeke B, Noton SL, Vanover D, Zurla C, Fearns R, Santangelo PJ. Polymerase-tagged respiratory syncytial virus reveals a dynamic rearrangement of the ribonucleocapsid complex during infection. Plos Pathogens. 16: e1008987. PMID 33031461 DOI: 10.1371/journal.ppat.1008987 |
0.572 |
|
| 2020 |
Kleiner VA, Fearns R. RSV M2-1 Protein in Complex with RNA: Old Questions Are Answered and a New One Emerges. Structure (London, England : 1993). 28: 977-978. PMID 32877647 DOI: 10.1016/J.Str.2020.08.007 |
0.509 |
|
| 2019 |
Ludeke B, Fearns R. The respiratory syncytial virus polymerase can perform RNA synthesis with modified primers and nucleotide analogs. Virology. 540: 66-74. PMID 31739186 DOI: 10.1016/J.Virol.2019.11.002 |
0.63 |
|
| 2019 |
Fearns R. The Respiratory Syncytial Virus Polymerase: A Multitasking Machine. Trends in Microbiology. PMID 31672264 DOI: 10.1016/J.Tim.2019.10.001 |
0.522 |
|
| 2019 |
Deflubé LR, Cressey TN, Hume AJ, Olejnik J, Haddock E, Feldmann F, Ebihara H, Fearns R, Mühlberger E. Ebolavirus polymerase uses an unconventional genome replication mechanism. Proceedings of the National Academy of Sciences of the United States of America. 116: 8535-8543. PMID 30962389 DOI: 10.1073/Pnas.1815745116 |
0.644 |
|
| 2019 |
Noton SL, Tremaglio CZ, Fearns R. Killing two birds with one stone: How the respiratory syncytial virus polymerase initiates transcription and replication. Plos Pathogens. 15: e1007548. PMID 30817806 DOI: 10.1371/Journal.Ppat.1007548 |
0.732 |
|
| 2018 |
Badolo A, Burt F, Daniel S, Fearns R, Gudo ES, Kielian M, Lescar J, Shi Y, von Brunn A, Weiss SR, Hilgenfeld R. Third Tofo Advanced Study Week on Emerging and Re-emerging Viruses, 2018. Antiviral Research. 162: 142-150. PMID 30597184 DOI: 10.1016/J.Antiviral.2018.12.015 |
0.495 |
|
| 2018 |
Cox RM, Toots M, Yoon JJ, Sourimant J, Ludeke B, Fearns R, Bourque E, Patti J, Lee E, Vernachio J, Plemper RK. Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex. The Journal of Biological Chemistry. PMID 30206124 DOI: 10.1074/Jbc.Ra118.004862 |
0.532 |
|
| 2018 |
Yoon JJ, Toots M, Lee S, Lee ME, Ludeke B, Luczo JM, Ganti K, Cox RM, Sticher ZM, Edpuganti V, Mitchell DG, Lockwood MA, Kolykhalov AA, Greninger AL, Moore ML, ... ... Fearns R, et al. Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses. Antimicrobial Agents and Chemotherapy. PMID 29891600 DOI: 10.1128/Aac.00766-18 |
0.507 |
|
| 2018 |
Cressey TN, Noton SL, Nagendra K, Braun MR, Fearns R. Mechanism for de novo initiation at two sites in the respiratory syncytial virus promoter. Nucleic Acids Research. PMID 29873775 DOI: 10.1093/Nar/Gky480 |
0.648 |
|
| 2018 |
Atienza BJP, Jensen LD, Noton SL, Ansalem AKV, Hobman T, Fearns R, Marchant DJ, West FG. Dual Catalytic Synthesis of Antiviral Compounds Based on Metallocarbene-Azide Cascade Chemistry. The Journal of Organic Chemistry. PMID 29663810 DOI: 10.1021/Acs.Joc.8B00222 |
0.363 |
|
| 2017 |
Braun MR, Deflubé LR, Noton SL, Mawhorter ME, Tremaglio CZ, Fearns R. RNA elongation by respiratory syncytial virus polymerase is calibrated by conserved region V. Plos Pathogens. 13: e1006803. PMID 29281742 DOI: 10.1371/Journal.Ppat.1006803 |
0.758 |
|
| 2017 |
Fearns R, Plemper RK. Polymerases of paramyxoviruses and pneumoviruses. Virus Research. PMID 28104450 DOI: 10.1016/J.Virusres.2017.01.008 |
0.524 |
|
| 2016 |
Fearns R, Deval J. New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase. Antiviral Research. PMID 27575793 DOI: 10.1016/J.Antiviral.2016.08.006 |
0.696 |
|
| 2016 |
Duvall JR, VerPlank L, Ludeke B, McLeod SM, Lee MD, Vishwanathan K, Mulrooney CA, Le Quement S, Yu Q, Palmer MA, Fleming P, Fearns R, Foley MA, Scherer CA. Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen. Antiviral Research. PMID 27059228 DOI: 10.1016/J.Antiviral.2016.03.015 |
0.482 |
|
| 2016 |
Warren TK, Jordan R, Lo MK, Ray AS, Mackman RL, Soloveva V, Siegel D, Perron M, Bannister R, Hui HC, Larson N, Strickley R, Wells J, Stuthman KS, Van Tongeren SA, ... ... Fearns R, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. PMID 26934220 DOI: 10.1038/Nature17180 |
0.604 |
|
| 2015 |
Aljabr W, Touzelet O, Pollakis G, Wu W, Munday DC, Hughes M, Hertz-Fowler C, Kenny J, Fearns R, Barr JN, Matthews DA, Hiscox JA. Investigating the influence of ribavirin on human respiratory syncytial virus RNA synthesis using a high-resolution RNAseq approach. Journal of Virology. PMID 26656699 DOI: 10.1128/Jvi.02349-15 |
0.659 |
|
| 2015 |
McCutcheon KM, Jordan R, Mawhorter ME, Noton SL, Powers JG, Fearns R, Cihlar T, Perron M. The interferon type I/III response to respiratory syncytial virus infection in airway epithelial cells can be attenuated or amplified by antiviral treatment. Journal of Virology. PMID 26608311 DOI: 10.1128/Jvi.02417-15 |
0.597 |
|
| 2015 |
Deval J, Hong J, Wang G, Taylor J, Smith LK, Fung A, Stevens SK, Liu H, Jin Z, Dyatkina N, Prhavc M, Stoycheva AD, Serebryany V, Liu J, Smith DB, ... ... Fearns R, et al. Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate. Plos Pathogens. 11: e1004995. PMID 26098424 DOI: 10.1371/Journal.Ppat.1004995 |
0.623 |
|
| 2015 |
Noton SL, Nagendra K, Dunn EF, Mawhorter ME, Yu Q, Fearns R. Respiratory Syncytial Virus Inhibitor AZ-27 Differentially Inhibits Different Polymerase Activities at the Promoter. Journal of Virology. 89: 7786-98. PMID 25995255 DOI: 10.1128/Jvi.00530-15 |
0.69 |
|
| 2015 |
Dickey LL, Duncan JK, Hanley TM, Fearns R. Decapping protein 1 phosphorylation modulates IL-8 expression during respiratory syncytial virus infection. Virology. 481: 199-209. PMID 25796077 DOI: 10.1016/J.Virol.2015.02.043 |
0.736 |
|
| 2015 |
Noton SL, Fearns R. Initiation and regulation of paramyxovirus transcription and replication. Virology. 479: 545-54. PMID 25683441 DOI: 10.1016/j.virol.2015.01.014 |
0.572 |
|
| 2015 |
Munday DC, Wu W, Smith N, Fix J, Noton SL, Galloux M, Touzelet O, Armstrong SD, Dawson JM, Aljabr W, Easton AJ, Rameix-Welti MA, de Oliveira AP, Simabuco FM, Ventura AM, ... ... Fearns R, et al. Interactome analysis of the human respiratory syncytial virus RNA polymerase complex identifies protein chaperones as important cofactors that promote L-protein stability and RNA synthesis. Journal of Virology. 89: 917-30. PMID 25355874 DOI: 10.1128/Jvi.01783-14 |
0.554 |
|
| 2014 |
Persson BD, Jaffe AB, Fearns R, Danahay H. Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation. Plos One. 9: e102368. PMID 25033192 DOI: 10.1371/Journal.Pone.0102368 |
0.37 |
|
| 2014 |
Noton SL, Aljabr W, Hiscox JA, Matthews DA, Fearns R. Factors affecting de novo RNA synthesis and back-priming by the respiratory syncytial virus polymerase. Virology. 462: 318-27. PMID 25010481 DOI: 10.1016/J.Virol.2014.05.032 |
0.68 |
|
| 2013 |
Collins PL, Fearns R, Graham BS. Respiratory syncytial virus: virology, reverse genetics, and pathogenesis of disease. Current Topics in Microbiology and Immunology. 372: 3-38. PMID 24362682 DOI: 10.1007/978-3-642-38919-1_1 |
0.409 |
|
| 2013 |
Tremaglio CZ, Noton SL, Deflubé LR, Fearns R. Respiratory syncytial virus polymerase can initiate transcription from position 3 of the leader promoter. Journal of Virology. 87: 3196-207. PMID 23283954 DOI: 10.1128/Jvi.02862-12 |
0.754 |
|
| 2012 |
Noton SL, Deflubé LR, Tremaglio CZ, Fearns R. The respiratory syncytial virus polymerase has multiple RNA synthesis activities at the promoter. Plos Pathogens. 8: e1002980. PMID 23093940 DOI: 10.1371/Journal.Ppat.1002980 |
0.757 |
|
| 2011 |
Noton SL, Fearns R. The first two nucleotides of the respiratory syncytial virus antigenome RNA replication product can be selected independently of the promoter terminus. Rna (New York, N.Y.). 17: 1895-906. PMID 21878549 DOI: 10.1261/Rna.2813411 |
0.697 |
|
| 2010 |
Hanley LL, McGivern DR, Teng MN, Djang R, Collins PL, Fearns R. Roles of the respiratory syncytial virus trailer region: effects of mutations on genome production and stress granule formation. Virology. 406: 241-52. PMID 20701943 DOI: 10.1016/J.Virol.2010.07.006 |
0.505 |
|
| 2010 |
Noton SL, Cowton VM, Zack CR, McGivern DR, Fearns R. Evidence that the polymerase of respiratory syncytial virus initiates RNA replication in a nontemplated fashion. Proceedings of the National Academy of Sciences of the United States of America. 107: 10226-31. PMID 20479224 DOI: 10.1073/Pnas.0913065107 |
0.688 |
|
| 2010 |
Barr JN, Fearns R. How RNA viruses maintain their genome integrity. The Journal of General Virology. 91: 1373-87. PMID 20335491 DOI: 10.1099/Vir.0.020818-0 |
0.556 |
|
| 2009 |
Dunn EF, Fearns R, Connor JH. Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism. Journal of Virology. 83: 11665-72. PMID 19740993 DOI: 10.1128/Jvi.01092-09 |
0.419 |
|
| 2009 |
Gallacher M, Brown SG, Hale BG, Fearns R, Olver RE, Randall RE, Wilson SM. Cation currents in human airway epithelial cells induced by infection with influenza A virus. The Journal of Physiology. 587: 3159-73. PMID 19403603 DOI: 10.1113/Jphysiol.2009.171223 |
0.395 |
|
| 2006 |
Cowton VM, McGivern DR, Fearns R. Unravelling the complexities of respiratory syncytial virus RNA synthesis. The Journal of General Virology. 87: 1805-21. PMID 16760383 DOI: 10.1099/Vir.0.81786-0 |
0.686 |
|
| 2005 |
Carlos TS, Fearns R, Randall RE. Interferon-induced alterations in the pattern of parainfluenza virus 5 transcription and protein synthesis and the induction of virus inclusion bodies Journal of Virology. 79: 14112-14121. PMID 16254346 DOI: 10.1128/Jvi.79.22.14112-14121.2005 |
0.506 |
|
| 2005 |
Cowton VM, Fearns R. Evidence that the respiratory syncytial virus polymerase is recruited to nucleotides 1 to 11 at the 3' end of the nucleocapsid and can scan to access internal signals. Journal of Virology. 79: 11311-22. PMID 16103183 DOI: 10.1128/Jvi.79.17.11311-11322.2005 |
0.703 |
|
| 2005 |
McGivern DR, Collins PL, Fearns R. Identification of internal sequences in the 3' leader region of human respiratory syncytial virus that enhance transcription and confer replication processivity. Journal of Virology. 79: 2449-60. PMID 15681446 DOI: 10.1128/Jvi.79.4.2449-2460.2005 |
0.653 |
|
| 2002 |
Fearns R, Peeples ME, Collins PL. Mapping the transcription and replication promoters of respiratory syncytial virus. Journal of Virology. 76: 1663-72. PMID 11799161 DOI: 10.1128/Jvi.76.4.1663-1672.2002 |
0.691 |
|
| 2000 |
Fearns R, Collins PL, Peeples ME. Functional analysis of the genomic and antigenomic promoters of human respiratory syncytial virus Journal of Virology. 74: 6006-6014. PMID 10846082 DOI: 10.1128/Jvi.74.13.6006-6014.2000 |
0.63 |
|
| 1999 |
Collins PL, Whitehead SS, Bukreyev A, Fearns R, Teng MN, Juhasz K, Chanock RM, Murphy BR. Rational design of live-attenuated recombinant vaccine virus for human respiratory syncytial virus by reverse genetics. Advances in Virus Research. 54: 423-51. PMID 10547682 DOI: 10.1016/S0065-3527(08)60374-7 |
0.453 |
|
| 1999 |
Fearns R, Collins PL. Role of the M2-1 transcription antitermination protein of respiratory syncytial virus in sequential transcription Journal of Virology. 73: 5852-5864. PMID 10364337 DOI: 10.1128/Jvi.73.7.5852-5864.1999 |
0.517 |
|
| 1999 |
Fearns R, Collins PL. Model for polymerase access to the overlapped L gene respiratory syncytial virus Journal of Virology. 73: 388-397. PMID 9847343 DOI: 10.1128/Jvi.73.1.388-397.1999 |
0.411 |
|
| 1997 |
Fearns R, Peeples ME, Collins PL. Increased expression of the N protein of respiratory syncytial virus stimulates minigenome replication but does not alter the balance between the synthesis of mRNA and antigenome Virology. 236: 188-201. PMID 9299631 DOI: 10.1006/Viro.1997.8734 |
0.659 |
|
| 1997 |
Kuo L, Fearns R, Collins PL. Analysis of the gene start and gene end signals of human respiratory syncytial virus: Quasi-templated initiation at position 1 of the encoded mRNA Journal of Virology. 71: 4944-4953. PMID 9188557 DOI: 10.1128/Jvi.71.7.4944-4953.1997 |
0.445 |
|
| 1996 |
Kuo L, Fearns R, Collins PL. The structurally diverse intergenic regions of respiratory syncytial virus do not modulate sequential transcription by a dicistronic minigenome Journal of Virology. 70: 6143-6150. PMID 8709239 DOI: 10.1128/Jvi.70.9.6143-6150.1996 |
0.599 |
|
| 1994 |
Fearns R, Young DF, Randall RE. Evidence that the paramyxovirus simian virus 5 can establish quiescent infections by remaining inactive in cytoplasmic inclusion bodies Journal of General Virology. 75: 3525-3539. PMID 7996144 DOI: 10.1099/0022-1317-75-12-3525 |
0.474 |
|
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