Martin F. Flajnik - Publications

Affiliations: 
Molecular Microbiology and Immunology University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
Immunology

134 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Dornburg A, Ota T, Criscitiello MF, Salinas I, Sunyer JO, Magadán S, Boudinot P, Xu Z, Flajnik MF, Singer A, Gambón-Deza F, Hansen JD, Yoder JA. From IgZ to IgT: A Call for a Common Nomenclature for Immunoglobulin Heavy Chain Genes of Ray-Finned Fish. Zebrafish. 18: 343-345. PMID 34935497 DOI: 10.1089/zeb.2021.0071  0.638
2021 Flowers EM, Neely HR, Guo J, Almeida T, Ohta Y, Castro CD, Flajnik MF. Identification of the Fc-alpha/mu Receptor in Xenopus provides insight into the emergence of the poly-Ig receptor (pIgR) and mucosal Ig transport. European Journal of Immunology. PMID 34411303 DOI: 10.1002/eji.202149383  0.748
2021 Almeida T, Ohta Y, Gaigher A, Muñoz-Mérida A, Neves F, Castro LFC, Machado AM, Esteves PJ, Veríssimo A, Flajnik MF. A Highly Complex, MHC-Linked, 350 Million-Year-Old Shark Nonclassical Class I Lineage. Journal of Immunology (Baltimore, Md. : 1950). 207: 824-836. PMID 34301841 DOI: 10.4049/jimmunol.2000851  0.344
2021 Kinlein A, Janes ME, Kincer J, Almeida T, Matz H, Sui J, Criscitiello MF, Flajnik MF, Ohta Y. Analysis of shark NCR3 family genes reveals primordial features of vertebrate NKp30. Immunogenetics. PMID 33742259 DOI: 10.1007/s00251-021-01209-6  0.701
2021 Ott JA, Ohta Y, Flajnik MF, Criscitiello MF. Lost structural and functional inter-relationships between Ig and TCR loci in mammals revealed in sharks. Immunogenetics. PMID 33449123 DOI: 10.1007/s00251-020-01183-5  0.816
2020 Ott JA, Harrison J, Flajnik MF, Criscitiello MF. Nurse Shark T Cell Receptors Employ Somatic Hypermutation Preferentially to Alter Alpha/Delta Variable Segments Associated with Alpha Constant Region. European Journal of Immunology. PMID 32346855 DOI: 10.1002/Eji.201948495  0.814
2020 Almeida T, Esteves PJ, Flajnik MF, Ohta Y, Veríssimo A. An Ancient, MHC-Linked, Nonclassical Class I Lineage in Cartilaginous Fish. Journal of Immunology (Baltimore, Md. : 1950). PMID 31932500 DOI: 10.4049/Jimmunol.1901025  0.423
2020 Ott JA, Harrison J, Flajnik MF, Criscitiello MF. Author response for "Nurse Shark T Cell Receptors Employ Somatic Hypermutation Preferentially to Alter Alpha/Delta Variable Segments Associated with Alpha Constant Region" European Journal of Immunology. DOI: 10.1002/Eji.201948495/V2/Response1  0.793
2019 Ohta Y, Kasahara M, O'Connor TD, Flajnik MF. Inferring the "Primordial Immune Complex": Origins of MHC Class I and Antigen Receptors Revealed by Comparative Genomics. Journal of Immunology (Baltimore, Md. : 1950). PMID 31492741 DOI: 10.4049/Jimmunol.1900597  0.435
2019 Deiss TC, Breaux B, Ott JA, Daniel RA, Chen PL, Castro CD, Ohta Y, Flajnik MF, Criscitiello MF. Ancient Use of Ig Variable Domains Contributes Significantly to the TCRδ Repertoire. Journal of Immunology (Baltimore, Md. : 1950). PMID 31341077 DOI: 10.4049/Jimmunol.1900369  0.758
2019 Kasahara M, Flajnik MF. Origin and evolution of the specialized forms of proteasomes involved in antigen presentation. Immunogenetics. PMID 30675634 DOI: 10.1007/S00251-019-01105-0  0.442
2019 Feng M, Bian H, Wu X, Fu T, Fu Y, Hong J, Fleming BD, Flajnik MF, Ho M. Construction and next-generation sequencing analysis of a large phage-displayed V single-domain antibody library from six naïve nurse sharks. Antibody Therapeutics. 2: 1-11. PMID 30627698 DOI: 10.1093/abt/tby011  0.325
2018 Redmond AK, Ohta Y, Criscitiello MF, Macqueen DJ, Flajnik MF, Dooley H. Haptoglobin Is a Divergent MASP Family Member That Neofunctionalized To Recycle Hemoglobin via CD163 in Mammals. Journal of Immunology (Baltimore, Md. : 1950). PMID 30194112 DOI: 10.4049/Jimmunol.1800508  0.65
2018 Flajnik MF. A Convergent Immunological Holy Trinity of Adaptive Immunity in Lampreys: Discovery of the Variable Lymphocyte Receptors. Journal of Immunology (Baltimore, Md. : 1950). 201: 1331-1335. PMID 30127062 DOI: 10.4049/Jimmunol.1800965  0.374
2018 Ott JA, Castro CD, Deiss TC, Ohta Y, Flajnik MF, Criscitiello MF. Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus. Elife. 7. PMID 29664399 DOI: 10.7554/Elife.28477  0.78
2018 Flajnik MF. A cold-blooded view of adaptive immunity. Nature Reviews. Immunology. PMID 29556016 DOI: 10.1038/S41577-018-0003-9  0.42
2017 Neely HR, Guo J, Flowers EM, Criscitiello MF, Flajnik MF. "Double-duty" conventional dendritic cells in the amphibian Xenopus as the prototype for antigen presentation to B cells. European Journal of Immunology. PMID 29235109 DOI: 10.1002/Eji.201747260  0.677
2017 Iacoangeli A, Lui A, Haines A, Ohta Y, Flajnik M, Hsu E. Evidence for Ig Light Chain Isotype Exclusion in Shark B Lymphocytes Suggests Ordered Mechanisms. Journal of Immunology (Baltimore, Md. : 1950). PMID 28760881 DOI: 10.4049/Jimmunol.1700762  0.459
2017 Ott JA, Castro CD, Deiss TC, Ohta Y, Flajnik MF, Criscitiello MF. Author response: Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus Elife. DOI: 10.7554/Elife.28477.033  0.77
2016 Session AM, Uno Y, Kwon T, Chapman JA, Toyoda A, Takahashi S, Fukui A, Hikosaka A, Suzuki A, Kondo M, van Heeringen SJ, Quigley I, Heinz S, Ogino H, Ochi H, ... ... Flajnik MF, et al. Genome evolution in the allotetraploid frog Xenopus laevis. Nature. 538: 336-343. PMID 27762356 DOI: 10.1038/Nature19840  0.329
2016 Zajonc DM, Flajnik MF. CD1, MR1, NKT, and MAIT: evolution and origins of non-peptidic antigen recognition by T lymphocytes. Immunogenetics. PMID 27480412 DOI: 10.1007/S00251-016-0941-Y  0.316
2016 Flajnik MF. Evidence of G.O.D.'s Miracle: Unearthing a RAG Transposon. Cell. 166: 11-2. PMID 27368095 DOI: 10.1016/J.Cell.2016.06.021  0.379
2016 Neely HR, Flajnik MF. Emergence and Evolution of Secondary Lymphoid Organs. Annual Review of Cell and Developmental Biology. PMID 27362646 DOI: 10.1146/Annurev-Cellbio-111315-125306  0.351
2016 Barreda DR, Neely HR, Flajnik MF. Evolution of Myeloid Cells. Microbiology Spectrum. 4. PMID 27337471 DOI: 10.1128/Microbiolspec.Mchd-0007-2015  0.339
2016 Häsler J, Flajnik MF, Williams G, Walsh FS, Rutkowski JL. VNAR single-domain antibodies specific for BAFF inhibit B cell development by molecular mimicry. Molecular Immunology. 75: 28-37. PMID 27213814 DOI: 10.1016/J.Molimm.2016.05.009  0.405
2015 Iacoangeli A, Lui A, Naik U, Ohta Y, Flajnik M, Hsu E. Biased immunoglobulin light chain gene usage in the shark Journal of Immunology. 195: 3992-4000. PMID 26342033 DOI: 10.4049/Jimmunol.1501426  0.377
2015 Ohta Y, Flajnik MF. Coevolution of MHC genes (LMP/TAP/class Ia, NKT-class Ib, NKp30-B7H6): lessons from cold-blooded vertebrates. Immunological Reviews. 267: 6-15. PMID 26284468 DOI: 10.1111/Imr.12324  0.49
2015 Neely HR, Flajnik MF. CXCL13 responsiveness but not CXCR5 expression by late transitional B cells initiates splenic white pulp formation. Journal of Immunology (Baltimore, Md. : 1950). 194: 2616-23. PMID 25662995 DOI: 10.4049/Jimmunol.1401905  0.38
2014 Flajnik MF. Re-evaluation of the immunological Big Bang. Current Biology : Cb. 24: R1060-5. PMID 25517375 DOI: 10.1016/J.Cub.2014.09.070  0.423
2014 Castro CD, Flajnik MF. Putting J chain back on the map: how might its expression define plasma cell development? Journal of Immunology (Baltimore, Md. : 1950). 193: 3248-55. PMID 25240020 DOI: 10.4049/Jimmunol.1400531  0.754
2014 Venkatesh B, Lee AP, Swann JB, Ohta Y, Flajnik MF, Kasahara M, Boehm T, Warren WC. Venkatesh et al. reply. Nature. 511: E9-10. PMID 25008535 DOI: 10.1038/Nature13447  0.321
2014 Feige MJ, Gräwert MA, Marcinowski M, Hennig J, Behnke J, Ausländer D, Herold EM, Peschek J, Castro CD, Flajnik M, Hendershot LM, Sattler M, Groll M, Buchner J. The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins. Proceedings of the National Academy of Sciences of the United States of America. 111: 8155-60. PMID 24830426 DOI: 10.1073/Pnas.1321502111  0.733
2014 Venkatesh B, Lee AP, Ravi V, Maurya AK, Lian MM, Swann JB, Ohta Y, Flajnik MF, Sutoh Y, Kasahara M, Hoon S, Gangu V, Roy SW, Irimia M, Korzh V, et al. Elephant shark genome provides unique insights into gnathostome evolution. Nature. 505: 174-9. PMID 24402279 DOI: 10.1038/Nature12826  0.368
2013 Castro CD, Ohta Y, Dooley H, Flajnik MF. Noncoordinate expression of J-chain and Blimp-1 define nurse shark plasma cell populations during ontogeny. European Journal of Immunology. 43: 3061-75. PMID 23897025 DOI: 10.1002/Eji.201343416  0.771
2012 Marancik DP, Leary JH, Fast MM, Flajnik MF, Camus AC. Humoral response of captive zebra sharks Stegostoma fasciatum to salivary gland proteins of the leech Branchellion torpedinis. Fish & Shellfish Immunology. 33: 1000-7. PMID 22963935 DOI: 10.1016/J.Fsi.2012.08.020  0.307
2012 Flajnik MF, Tlapakova T, Criscitiello MF, Krylov V, Ohta Y. Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7's historical relationship with the MHC. Immunogenetics. 64: 571-90. PMID 22488247 DOI: 10.1007/S00251-012-0616-2  0.662
2012 Smith LE, Crouch K, Cao W, Müller MR, Wu L, Steven J, Lee M, Liang M, Flajnik MF, Shih HH, Barelle CJ, Paulsen J, Gill DS, Dooley H. Characterization of the immunoglobulin repertoire of the spiny dogfish (Squalus acanthias). Developmental and Comparative Immunology. 36: 665-79. PMID 22040740 DOI: 10.1016/J.Dci.2011.10.007  0.38
2012 Criscitiello MF, Ohta Y, Graham MD, Eubanks JO, Chen PL, Flajnik MF. Shark class II invariant chain reveals ancient conserved relationships with cathepsins and MHC class II. Developmental and Comparative Immunology. 36: 521-33. PMID 21996610 DOI: 10.1016/J.Dci.2011.09.008  0.678
2011 Flajnik MF, Deschacht N, Muyldermans S. A case of convergence: why did a simple alternative to canonical antibodies arise in sharks and camels? Plos Biology. 9: e1001120. PMID 21829328 DOI: 10.1371/Journal.Pbio.1001120  0.494
2011 Zhu C, Feng W, Weedon J, Hua P, Stefanov D, Ohta Y, Flajnik MF, Hsu E. The multiple shark Ig H chain genes rearrange and hypermutate autonomously. Journal of Immunology (Baltimore, Md. : 1950). 187: 2492-501. PMID 21804022 DOI: 10.4049/Jimmunol.1101671  0.431
2011 Goodchild SA, Dooley H, Schoepp RJ, Flajnik M, Lonsdale SG. Isolation and characterisation of Ebolavirus-specific recombinant antibody fragments from murine and shark immune libraries. Molecular Immunology. 48: 2027-37. PMID 21752470 DOI: 10.1016/J.Molimm.2011.06.437  0.388
2011 Flajnik M. Immunology: The Origin of Sweetbreads in Lampreys? Current Biology. 21. PMID 21419986 DOI: 10.1016/J.Cub.2011.01.066  0.373
2011 Ohta Y, Shiina T, Lohr RL, Hosomichi K, Pollin TI, Heist EJ, Suzuki S, Inoko H, Flajnik MF. Primordial linkage of β2-microglobulin to the MHC. Journal of Immunology (Baltimore, Md. : 1950). 186: 3563-71. PMID 21321107 DOI: 10.4049/Jimmunol.1003933  0.45
2010 Dooley H, Buckingham EB, Criscitiello MF, Flajnik MF. Emergence of the acute-phase protein hemopexin in jawed vertebrates. Molecular Immunology. 48: 147-52. PMID 20884052 DOI: 10.1016/J.Molimm.2010.08.015  0.638
2010 Deng L, Velikovsky CA, Xu G, Iyer LM, Tasumi S, Kerzic MC, Flajnik MF, Aravind L, Pancer Z, Mariuzza RA. A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey. Proceedings of the National Academy of Sciences of the United States of America. 107: 13408-13. PMID 20616002 DOI: 10.1073/Pnas.1005475107  0.464
2010 Criscitiello MF, Ohta Y, Saltis M, McKinney EC, Flajnik MF. Evolutionarily conserved TCR binding sites, identification of T cells in primary lymphoid tissues, and surprising trans-rearrangements in nurse shark. Journal of Immunology (Baltimore, Md. : 1950). 184: 6950-60. PMID 20488795 DOI: 10.4049/Jimmunol.0902774  0.8
2010 Parra ZE, Ohta Y, Criscitiello MF, Flajnik MF, Miller RD. The dynamic TCRδ: TCRδ chains in the amphibian Xenopus tropicalis utilize antibody-like V genes. European Journal of Immunology. 40: 2319-29. PMID 20486124 DOI: 10.1002/Eji.201040515  0.724
2010 Flajnik MF, Kasahara M. Origin and evolution of the adaptive immune system: genetic events and selective pressures. Nature Reviews. Genetics. 11: 47-59. PMID 19997068 DOI: 10.1038/Nrg2703  0.382
2009 Tasumi S, Velikovsky CA, Xu G, Gai SA, Wittrup KD, Flajnik MF, Mariuzza RA, Pancer Z. High-affinity lamprey VLRA and VLRB monoclonal antibodies. Proceedings of the National Academy of Sciences of the United States of America. 106: 12891-6. PMID 19625627 DOI: 10.1073/Pnas.0904443106  0.407
2009 Flajnik MF, Dooley H. The generation and selection of single-domain, v region libraries from nurse sharks. Methods in Molecular Biology (Clifton, N.J.). 562: 71-82. PMID 19554288 DOI: 10.1007/978-1-60327-302-2_6  0.469
2008 Malecek K, Lee V, Feng W, Huang JL, Flajnik MF, Ohta Y, Hsu E. Immunoglobulin heavy chain exclusion in the shark. Plos Biology. 6: e157. PMID 18578572 DOI: 10.1371/Journal.Pbio.0060157  0.522
2008 Saltis M, Criscitiello MF, Ohta Y, Keefe M, Trede NS, Goitsuka R, Flajnik MF. Evolutionarily conserved and divergent regions of the autoimmune regulator (Aire) gene: a comparative analysis. Immunogenetics. 60: 105-14. PMID 18214467 DOI: 10.1007/S00251-007-0268-9  0.701
2007 Marr S, Morales H, Bottaro A, Cooper M, Flajnik M, Robert J. Localization and differential expression of activation-induced cytidine deaminase in the amphibian Xenopus upon antigen stimulation and during early development. Journal of Immunology (Baltimore, Md. : 1950). 179: 6783-9. PMID 17982068 DOI: 10.4049/Jimmunol.179.10.6783  0.389
2007 Criscitiello MF, Flajnik MF. Four primordial immunoglobulin light chain isotypes, including lambda and kappa, identified in the most primitive living jawed vertebrates. European Journal of Immunology. 37: 2683-94. PMID 17899545 DOI: 10.1002/Eji.200737263  0.651
2007 Stanfield RL, Dooley H, Verdino P, Flajnik MF, Wilson IA. Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding. Journal of Molecular Biology. 367: 358-72. PMID 17258766 DOI: 10.1016/J.Jmb.2006.12.045  0.396
2006 Ohta Y, Flajnik M. IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebrates Proceedings of the National Academy of Sciences of the United States of America. 103: 10723-10728. PMID 16818885 DOI: 10.1073/Pnas.0601407103  0.508
2006 Luo M, Kim H, Kudrna D, Sisneros NB, Lee SJ, Mueller C, Collura K, Zuccolo A, Buckingham EB, Grim SM, Yanagiya K, Inoko H, Shiina T, Flajnik MF, Wing RA, et al. Construction of a nurse shark (Ginglymostoma cirratum) bacterial artificial chromosome (BAC) library and a preliminary genome survey. Bmc Genomics. 7: 106. PMID 16672057 DOI: 10.1186/1471-2164-7-106  0.357
2006 Hsu E, Pulham N, Rumfelt LL, Flajnik MF. The plasticity of immunoglobulin gene systems in evolution. Immunological Reviews. 210: 8-26. PMID 16623761 DOI: 10.1111/J.0105-2896.2006.00366.X  0.474
2006 Criscitiello MF, Saltis M, Flajnik MF. An evolutionarily mobile antigen receptor variable region gene: doubly rearranging NAR-TcR genes in sharks. Proceedings of the National Academy of Sciences of the United States of America. 103: 5036-41. PMID 16549799 DOI: 10.1073/Pnas.0507074103  0.715
2006 Ohta Y, Goetz W, Hossain MZ, Nonaka M, Flajnik MF. Ancestral organization of the MHC revealed in the amphibian Xenopus. Journal of Immunology (Baltimore, Md. : 1950). 176: 3674-85. PMID 16517736  0.304
2006 Dooley H, Stanfield RL, Brady RA, Flajnik MF. First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate. Proceedings of the National Academy of Sciences of the United States of America. 103: 1846-51. PMID 16446445 DOI: 10.1073/Pnas.0508341103  0.451
2006 Dooley H, Flajnik MF. Antibody repertoire development in cartilaginous fish Developmental and Comparative Immunology. 30: 43-56. PMID 16146649 DOI: 10.1016/J.Dci.2005.06.022  0.433
2005 Malecek K, Brandman J, Brodsky JE, Ohta Y, Flajnik MF, Hsu E. Somatic hypermutation and junctional diversification at Ig heavy chain loci in the nurse shark. Journal of Immunology (Baltimore, Md. : 1950). 175: 8105-15. PMID 16339548 DOI: 10.4049/Jimmunol.175.12.8105  0.453
2005 Stewart R, Ohta Y, Minter RR, Gibbons T, Horton TL, Ritchie P, Horton JD, Flajnik MF, Watson MD. Cloning and characterization of Xenopus beta2-microglobulin. Developmental and Comparative Immunology. 29: 723-32. PMID 15854684 DOI: 10.1016/J.Dci.2004.12.004  0.403
2005 Flajnik MF. The last flag unfurled? A new immunoglobulin isotype in fish expressed in early development. Nature Immunology. 6: 229-30. PMID 15716968 DOI: 10.1038/Ni0305-229  0.4
2005 Dooley H, Flajnik MF. Shark immunity bites back: affinity maturation and memory response in the nurse shark, Ginglymostoma cirratum. European Journal of Immunology. 35: 936-45. PMID 15688348 DOI: 10.1002/Eji.200425760  0.4
2004 Flajnik MF, Du Pasquier L. Evolution of innate and adaptive immunity: can we draw a line? Trends in Immunology. 25: 640-4. PMID 15530832 DOI: 10.1016/J.It.2004.10.001  0.314
2004 Fleurant M, Changchien L, Chen CT, Flajnik MF, Hsu E. Shark Ig light chain junctions are as diverse as in heavy chains. Journal of Immunology (Baltimore, Md. : 1950). 173: 5574-82. PMID 15494507 DOI: 10.4049/Jimmunol.173.9.5574  0.446
2004 Ohta Y, Landis E, Boulay T, Phillips RB, Collet B, Secombes CJ, Flajnik MF, Hansen JD. Homologs of CD83 from elasmobranch and teleost fish. Journal of Immunology (Baltimore, Md. : 1950). 173: 4553-60. PMID 15383588 DOI: 10.4049/Jimmunol.173.7.4553  0.303
2004 Stanfield RL, Dooley H, Flajnik MF, Wilson IA. Crystal structure of a shark single-domain antibody V region in complex with lysozyme. Science (New York, N.Y.). 305: 1770-3. PMID 15319492 DOI: 10.1126/Science.1101148  0.383
2004 Rumfelt LL, Diaz M, Lohr RL, Mochon E, Flajnik MF. Unprecedented multiplicity of Ig transmembrane and secretory mRNA forms in the cartilaginous fish. Journal of Immunology (Baltimore, Md. : 1950). 173: 1129-39. PMID 15240702 DOI: 10.4049/Jimmunol.173.2.1129  0.395
2004 Rumfelt LL, Lohr RL, Dooley H, Flajnik MF. Diversity and repertoire of IgW and IgM VH families in the newborn nurse shark. Bmc Immunology. 5: 8. PMID 15132758 DOI: 10.1186/1471-2172-5-8  0.417
2003 Ohta Y, Powis SJ, Lohr RL, Nonaka M, Pasquier LD, Flajnik MF. Two highly divergent ancient allelic lineages of the transporter associated with antigen processing (TAP) gene in Xenopus: further evidence for co-evolution among MHC class I region genes. European Journal of Immunology. 33: 3017-27. PMID 14579270 DOI: 10.1002/Eji.200324207  0.79
2003 Terado T, Okamura K, Ohta Y, Shin DH, Smith SL, Hashimoto K, Takemoto T, Nonaka MI, Kimura H, Flajnik MF, Nonaka M. Molecular cloning of C4 gene and identification of the class III complement region in the shark MHC. Journal of Immunology (Baltimore, Md. : 1950). 171: 2461-6. PMID 12928394 DOI: 10.4049/Jimmunol.171.5.2461  0.388
2003 Dooley H, Flajnik MF, Porter AJ. Selection and characterization of naturally occurring single-domain (IgNAR) antibody fragments from immunized sharks by phage display. Molecular Immunology. 40: 25-33. PMID 12909128 DOI: 10.1016/S0161-5890(03)00084-1  0.444
2003 Hohman VS, Stewart SE, Rumfelt LL, Greenberg AS, Avila DW, Flajnik MF, Steiner LA. J chain in the nurse shark: implications for function in a lower vertebrate. Journal of Immunology (Baltimore, Md. : 1950). 170: 6016-23. PMID 12794129 DOI: 10.4049/Jimmunol.170.12.6016  0.439
2002 Diaz M, Stanfield RL, Greenberg AS, Flajnik MF. Structural analysis, selection, and ontogeny of the shark new antigen receptor (IgNAR): identification of a new locus preferentially expressed in early development. Immunogenetics. 54: 501-12. PMID 12389098 DOI: 10.1007/S00251-002-0479-Z  0.446
2002 Flajnik MF. Comparative analyses of immunoglobulin genes: surprises and portents. Nature Reviews. Immunology. 2: 688-98. PMID 12209137 DOI: 10.1038/Nri889  0.457
2002 Liu Y, Kasahara M, Rumfelt LL, Flajnik MF. Xenopus class II A genes: studies of genetics, polymorphism, and expression. Developmental and Comparative Immunology. 26: 735-50. PMID 12206837 DOI: 10.1016/S0145-305X(02)00034-4  0.417
2002 Nagata T, Suzuki T, Ohta Y, Flajnik MF, Kasahara M. The leukocyte common antigen (CD45) of the Pacific hagfish, Eptatretus stoutii: implications for the primordial function of CD45. Immunogenetics. 54: 286-91. PMID 12136341 DOI: 10.1007/S00251-002-0469-1  0.362
2002 Rumfelt LL, McKinney EC, Taylor E, Flajnik MF. The development of primary and secondary lymphoid tissues in the nurse shark Ginglymostoma cirratum: B-cell zones precede dendritic cell immigration and t-cell zone formation during ontogeny of the spleen Scandinavian Journal of Immunology. 56: 130-148. PMID 12121433 DOI: 10.1046/J.1365-3083.2002.01116.X  0.696
2002 Lee SS, Tranchina D, Ohta Y, Flajnik MF, Hsu E. Hypermutation in shark immunoglobulin light chain genes results in contiguous substitutions. Immunity. 16: 571-82. PMID 11970880 DOI: 10.1016/S1074-7613(02)00300-X  0.365
2002 Ohta Y, McKinney EC, Criscitiello MF, Flajnik MF. Proteasome, transporter associated with antigen processing, and class I genes in the nurse shark Ginglymostoma cirratum: evidence for a stable class I region and MHC haplotype lineages. Journal of Immunology (Baltimore, Md. : 1950). 168: 771-81. PMID 11777971 DOI: 10.4049/Jimmunol.168.2.771  0.773
2001 Flajnik MF, Kasahara M. Comparative genomics of the MHC: Glimpses into the evolution of the adaptive immune system Immunity. 15: 351-362. PMID 11567626 DOI: 10.1016/S1074-7613(01)00198-4  0.413
2001 Diaz M, Verkoczy LK, Flajnik MF, Klinman NR. Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase ζ1 Journal of Immunology. 167: 327-335. PMID 11418667 DOI: 10.4049/Jimmunol.167.1.327  0.324
2001 Zan H, Komori A, Li Z, Cerutti A, Schaffer A, Flajnik MF, Diaz M, Casali P. The translesion DNA polymerase ζ plays a major role in Ig and bcl-6 somatic hypermutation Immunity. 14: 643-653. PMID 11371365 DOI: 10.1016/S1074-7613(01)00142-X  0.314
2001 Diaz M, Flajnik MF, Klinman N. Evolution and the molecular basis of somatic hypermutation of antigen receptor genes Philosophical Transactions of the Royal Society B: Biological Sciences. 355: 67-72. PMID 11205333 DOI: 10.1098/Rstb.2000.0750  0.424
2001 Rumfelt LL, Avila D, Diaz M, Bartl S, McKinney EC, Flajnik MF. A shark antibody heavy chain encoded by a nonsomatically rearranged VDJ is preferentially expressed in early development and is convergent with mammalian IgG Proceedings of the National Academy of Sciences of the United States of America. 98: 1775-1780. PMID 11172027 DOI: 10.1073/Pnas.98.4.1775  0.7
2001 Courtet M, Flajnik M, Pasquier LD. Major histocompatibility complex and immunoglobulin loci visualized by in situ hybridization on Xenopus chromosomes. Developmental and Comparative Immunology. 25: 149-157. PMID 11113284 DOI: 10.1016/S0145-305X(00)00045-8  0.37
2000 Lee SS, Fitch D, Flajnik MF, Hsu E. Rearrangement of immunoglobulin genes in shark germ cells Journal of Experimental Medicine. 191: 1637-1647. PMID 10811858 DOI: 10.1084/Jem.191.10.1637  0.463
2000 Flajnik MF, Rumfelt LL. The immune system of cartilaginous fish Current Topics in Microbiology and Immunology. 248: 249-270. PMID 10793481 DOI: 10.1007/978-3-642-59674-2_11  0.454
2000 Ohta Y, Okamura K, McKinney EC, Bartl S, Hashimoto K, Flajnik MF. Primitive synteny of vertebrate major histocompatibility complex class I and class II genes Proceedings of the National Academy of Sciences of the United States of America. 97: 4712-4717. PMID 10781076 DOI: 10.1073/Pnas.97.9.4712  0.664
2000 Nonaka M, Yamada-Namikawa C, Flajnik MF, Du Pasquier L. Trans-species polymorphism of the major histocompatibility complex-encoded proteasome subunit LMP7 in an amphibian genus, Xenopus Immunogenetics. 51: 186-192. PMID 10752627 DOI: 10.1007/S002510050030  0.397
1999 Ohta Y, Haliniewski DE, Hansen J, Flajnik MF. Isolation of transporter associated with antigen processing genes, TAP1 and TAP2, from the horned shark Heterodontus francisci Immunogenetics. 49: 981-986. PMID 10501841 DOI: 10.1007/S002510050582  0.304
1999 Diaz M, Velez J, Singh M, Cerny J, Flajnik MF. Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: The translesion synthesis model of somatic hypermutation International Immunology. 11: 825-833. PMID 10330287 DOI: 10.1093/Intimm/11.5.825  0.328
1999 Flajnik MF, Ohta Y, Namikawa-Yamada C, Nonaka M. Insight into the primordial MHC from studies in ectothermic vertebrates Immunological Reviews. 167: 59-67. PMID 10319251 DOI: 10.1111/J.1600-065X.1999.Tb01382.X  0.422
1999 Ohta Y, Powis SJ, Coadwell WJ, Haliniewski DE, Liu Y, Li H, Flajnik MF. Identification and genetic mapping of Xenopus TAP2 genes. Immunogenetics. 49: 171-82. PMID 9914331 DOI: 10.1007/S002510050478  0.428
1998 Diaz M, Greenberg AS, Flajnik MF. Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers. Proceedings of the National Academy of Sciences of the United States of America. 95: 14343-8. PMID 9826702 DOI: 10.1073/Pnas.95.24.14343  0.457
1998 Roux KH, Greenberg AS, Greene L, Strelets L, Avila D, McKinney EC, Flajnik MF. Structural analysis of the nurse shark (new) antigen receptor (NAR): molecular convergence of NAR and unusual mammalian immunoglobulins. Proceedings of the National Academy of Sciences of the United States of America. 95: 11804-9. PMID 9751746 DOI: 10.1073/Pnas.95.20.11804  0.731
1998 Du Pasquier L, Wilson M, Greenberg AS, Flajnik MF. Somatic mutation in ectothermic vertebrates: musings on selection and origins. Current Topics in Microbiology and Immunology. 229: 199-216. PMID 9479856 DOI: 10.1007/978-3-642-71984-4_14  0.406
1997 Bartl S, Baish MA, Flajnik MF, Ohta Y. Identification of Class I Genes in Cartilaginous Fish, the Most Ancient Group of Vertebrates Displaying an Adaptive Immune Response Journal of Immunology. 159: 6097-6104. PMID 9550410  0.314
1997 Nonaka M, Namikawa C, Kato Y, Sasaki M, Salter-Cid L, Flajnik MF. Major histocompatibility complex gene mapping in the amphibian Xenopus implies a primordial organization Proceedings of the National Academy of Sciences of the United States of America. 94: 5789-5791. PMID 9159152 DOI: 10.1073/Pnas.94.11.5789  0.428
1997 McKinney EC, Flajnik MF. IgM-mediated opsonization and cytotoxicity in the shark Journal of Leukocyte Biology. 61: 141-146. PMID 9021918 DOI: 10.1002/Jlb.61.2.141  0.637
1997 McKinney E, Henderson R, Ota Y, Flajnik M. U3 10:45 Cloning and expression of the T cell receptor β chain from the nurse shark Developmental & Comparative Immunology. 21: 238. DOI: 10.1016/S0145-305X(97)88773-3  0.665
1997 Bartl S, Baish MA, Flajnik MF, Ohta Y. D4 2:15 Full-length MHC class I CDNA clones and isolated from cartilaginous fishes Developmental & Comparative Immunology. 21: 106. DOI: 10.1016/S0145-305X(97)88545-X  0.325
1997 Flajnik M. Secreted antigen receptors in cartilaginous fish Developmental & Comparative Immunology. 21: 82-83. DOI: 10.1016/S0145-305X(97)88510-2  0.377
1996 Flajnik MF. The immune system of ectothermic vertebrates Veterinary Immunology and Immunopathology. 54: 145-150. PMID 8988858 DOI: 10.1016/S0165-2427(96)05685-1  0.458
1996 Kasahara M, Kandil E, Salter-Cid L, Flajnik MF. Origin and evolution of the class I gene family: Why are some of the mammalian class I genes encoded outside the major histocompatibility complex? Research in Immunology. 147: 278-285. PMID 8876055 DOI: 10.1016/0923-2494(96)89640-4  0.366
1996 Greenberg AS, Hughes AL, Guo J, Avila D, McKinney EC, Flajnik MF. A novel "chimeric" antibody class in cartilaginous fish: IgM may not be the primordial immunoglobulin. European Journal of Immunology. 26: 1123-9. PMID 8647177 DOI: 10.1002/Eji.1830260525  0.697
1995 Salter-Cid L, Flajnik MF. Evolution and developmental regulation of the major histocompatibility complex Critical Reviews in Immunology. 15: 31-75. PMID 8519422 DOI: 10.1615/Critrevimmunol.V15.I1.20  0.394
1995 Greenberg AS, Avila D, Hughes M, Hughes A, McKinney EC, Flajnik MF. A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks. Nature. 374: 168-73. PMID 7877689 DOI: 10.1038/374168a0  0.686
1995 Kato Y, Salter-Cid L, Flajnik MF, Namikawa C, Sasaki M, Nonaka M. Duplication of the MHC-linked Xenopus complement factor B gene Immunogenetics. 42: 196-203. PMID 7642231 DOI: 10.1007/Bf00191225  0.381
1995 Kobari F, Sato K, Shum BP, Tochinai S, Katagiri M, Ishibashi T, Du Pasquier L, Flajnik MF, Kasahara M. Exon-intron organization of Xenopus MHC class II β chain genes Immunogenetics. 42: 376-385. PMID 7590971 DOI: 10.1007/Bf00179399  0.397
1994 Salter-Cid L, Kasahara M, Flajnik MF. Hsp70 genes are linked to the Xenopus major histocompatibility complex Immunogenetics. 39: 1-7. PMID 7901155 DOI: 10.1007/Bf00171790  0.364
1994 Barré S, Greenberg AS, Flajnik MF, Chothia C. Structural conservation of hypervariable regions in immunoglobulins evolution. Nature Structural Biology. 1: 915-20. PMID 7773781 DOI: 10.1038/Nsb1294-915  0.366
1994 Flajnik MF. Primitive vertebrate immunity: what is the evolutionary derivative of molecules that define the adaptive immune system? Ciba Foundation Symposium. 186: 224-232; discussion . PMID 7768153  0.333
1994 Kaufman J, Salomonsen J, Flajnik M. Evolutionary conservation of MHC class I and class II molecules--different yet the same. Seminars in Immunology. 6: 411-424. PMID 7654997 DOI: 10.1006/Smim.1994.1050  0.354
1993 Kasahara M, McKinney EC, Flajnik MF, Ishibashi T. The evolutionary origin of the major histocompatibility complex: Polymorphism of class II α chain genes in the cartilaginous fish European Journal of Immunology. 23: 2160-2165. PMID 8370399  0.675
1993 Greenberg AS, Steiner L, Kasahara M, Flajnik MF. Isolation of a shark immunoglobulin light chain cDNA clone encoding a protein resembling mammalian kappa light chains: implications for the evolution of light chains. Proceedings of the National Academy of Sciences of the United States of America. 90: 10603-7. PMID 8248152 DOI: 10.1073/Pnas.90.22.10603  0.392
1993 Flajnik MF, Kasahara M, Shum BP, Salter-Cid L, Taylor E, Du Pasquier L. A novel type of class I gene organization in vertebrates: A large family of non-MHC-linked class I genes is expressed at the RNA level in the amphibian Xenopus Embo Journal. 12: 4385-4396. PMID 8223448 DOI: 10.1002/J.1460-2075.1993.Tb06123.X  0.429
1993 Harding FA, Flajnik MF, Cohen N. MHC restriction of T-cell proliferative responses in Xenopus Developmental and Comparative Immunology. 17: 425-437. PMID 7505753 DOI: 10.1016/0145-305X(93)90034-N  0.418
1992 Kasahara M, Vazquez M, Sato K, Churchill Mckinney E, Flajnik MF. Evolution of the major histocompatibility complex: Isolation of class II A cDNA clones from the cartilaginous fish Proceedings of the National Academy of Sciences of the United States of America. 89: 6688-6692. PMID 1495958 DOI: 10.1073/Pnas.89.15.6688  0.494
1992 Vazquez M, Mizuki N, Flajnik MF, McKinney EC, Kasahara M. Nucleotide sequence of a nurse shark immunoglobulin heavy chain cDNA clone Molecular Immunology. 29: 1157-1158. PMID 1495502 DOI: 10.1016/0161-5890(92)90050-8  0.627
1991 Grossberger D, Flajnik M, Marcus A. Ribosomal and chromosomal protein cDNA clones of Xenopus laevis thymus isolated with differential screening Comparative Biochemistry and Physiology B. 98: 127-133. PMID 2060276 DOI: 10.1016/0305-0491(91)90318-8  0.35
1991 Hsu E, Lefkovits I, Flajnik M, Du Pasquier L. Light chain heterogeneity in the amphibian Xenopus. Molecular Immunology. 28: 985-94. PMID 1922112 DOI: 10.1016/0161-5890(91)90184-L  0.335
1991 Flajnik MF, Canel C, Kramer J, Kasahara M. Evolution of the major histocompatibility complex: Molecular Cloning of major histocompatibility complex class I from the amphibian Xenopus Proceedings of the National Academy of Sciences of the United States of America. 88: 537-541. PMID 1703301 DOI: 10.1073/Pnas.88.2.537  0.383
1991 Flajnik MF, Taylor E, Canel C, Grossberger D, Pasquier LD. Reagents specific for MHC class I antigens of Xenopus Integrative and Comparative Biology. 31: 580-591. DOI: 10.1093/Icb/31.3.580  0.379
1990 Flajnik MF, Ferrone S, Cohen N, Pasquier LD. Evolution of the MHC: Antigenicity and unusual tissue distribution of Xenopus (frog) class II molecules Molecular Immunology. 27: 451-462. PMID 2366760 DOI: 10.1016/0161-5890(90)90170-5  0.388
1990 Houssaint E, Flajnik M. The role of thymic epithelium in the acquisition of tolerance Immunology Today. 11: 357-360. PMID 2222760 DOI: 10.1016/0167-5699(90)90141-U  0.397
1990 Du Pasquier L, Flajnik MF. Expression of Mhc Class Ii Antigens During Xenopus Development Developmental Immunology. 1: 85-95. PMID 2136209 DOI: 10.1155/1990/67913  0.372
1988 Flajnik MF, Du Pasquier L. MHC class I antigens as surface markers of adult erythrocytes during the metamorphosis of Xenopus Developmental Biology. 128: 198-206. PMID 3384174 DOI: 10.1016/0012-1606(88)90282-5  0.368
1987 Flajnik MF, Hsu E, Kaufman JF, Pasquier LD. Changes in the immune system during metamorphosis of Xenopus. Immunology Today. 8: 58-64. PMID 25291685 DOI: 10.1016/0167-5699(87)90240-4  0.322
1985 Flajnik MF, Du Pasquier L, Cohen N. Immune responses of thymus/lymphocyte embryonic chimeras: Studies on tolerance and major histocompatibility complex restriction in Xenopus European Journal of Immunology. 15: 540-547. PMID 3874068 DOI: 10.1002/Eji.1830150603  0.304
1984 Flajnik MF, Kaufman JF, Riegert P, Du Pasquier L. Identification of class I major histocompatibility complex encoded molecules in the amphibian Xenopus Immunogenetics. 20: 433-442. PMID 6490110 DOI: 10.1007/Bf00345617  0.384
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