Year |
Citation |
Score |
2008 |
Bender RP, Jablonksy MJ, Shadid M, Romaine I, Dunlap N, Anklin C, Graves DE, Osheroff N. Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity. Biochemistry. 47: 4501-9. PMID 18355043 DOI: 10.1021/Bi702019Z |
0.752 |
|
2007 |
Wilstermann AM, Bender RP, Godfrey M, Choi S, Anklin C, Berkowitz DB, Osheroff N, Graves DE. Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme. Biochemistry. 46: 8217-25. PMID 17580961 DOI: 10.1021/Bi700272U |
0.515 |
|
2007 |
Bender RP, Osheroff N. Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. Chemical Research in Toxicology. 20: 975-81. PMID 17516663 DOI: 10.1021/Tx700062T |
0.724 |
|
2007 |
Bender RP, Ham AJ, Osheroff N. Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405. Biochemistry. 46: 2856-64. PMID 17298034 DOI: 10.1021/Bi062017L |
0.701 |
|
2006 |
Bender RP, Lehmler HJ, Robertson LW, Ludewig G, Osheroff N. Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate. Biochemistry. 45: 10140-52. PMID 16906772 DOI: 10.1021/Bi0524666 |
0.662 |
|
2005 |
Lindsey RH, Bender RP, Osheroff N. Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites. Chemico-Biological Interactions. 153: 197-205. PMID 15935817 DOI: 10.1016/J.Cbi.2005.03.035 |
0.748 |
|
2005 |
Lindsey RH, Bender RP, Osheroff N. Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison. Chemical Research in Toxicology. 18: 761-70. PMID 15833037 DOI: 10.1021/Tx049659Z |
0.678 |
|
2004 |
Bender RP, Lindsey RH, Burden DA, Osheroff N. N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison. Biochemistry. 43: 3731-9. PMID 15035644 DOI: 10.1021/Bi036107R |
0.731 |
|
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