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Katharina Schlacher, Ph.D. - Publications

Affiliations: 
2006 University of Southern California, Los Angeles, CA, United States 
Area:
Molecular Biology
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ye Z, Xu S, Shi Y, Cheng X, Zhang Y, Roy S, Namjoshi S, Longo MA, Link TM, Schlacher K, Peng G, Yu D, Wang B, Tainer JA, Ahmed Z. GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. Nature Communications. 15: 2132. PMID 38459011 DOI: 10.1038/s41467-024-46283-y  0.42
2023 Longo MA, Roy S, Chen Y, Tomaszowski KH, Arvai AS, Pepper JT, Boisvert RA, Kunnimalaiyaan S, Keshvani C, Schild D, Bacolla A, Williams GJ, Tainer JA, Schlacher K. RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles. Nature Communications. 14: 4445. PMID 37488098 DOI: 10.1038/s41467-023-40096-1  0.374
2023 Lozen M, Chen Y, Boisvert RA, Schlacher K. Mitochondrial Replication Assay (MIRA) for Efficient in situ Quantification of Nascent mtDNA and Protein Interactions with Nascent mtDNA (mitoSIRF). Bio-Protocol. 13: e4680. PMID 37251092 DOI: 10.21769/BioProtoc.4680  0.327
2021 Luzwick JW, Dombi E, Boisvert RA, Roy S, Park S, Kunnimalaiyaan S, Goffart S, Schindler D, Schlacher K. MRE11-dependent instability in mitochondrial DNA fork protection activates a cGAS immune signaling pathway. Science Advances. 7: eabf9441. PMID 34910513 DOI: 10.1126/sciadv.abf9441  0.312
2021 Hambarde S, Tsai CL, Pandita RK, Bacolla A, Maitra A, Charaka V, Hunt CR, Kumar R, Limbo O, Le Meur R, Chazin WJ, Tsutakawa SE, Russell P, Schlacher K, Pandita TK, et al. EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart. Molecular Cell. PMID 34197737 DOI: 10.1016/j.molcel.2021.05.027  0.542
2020 Msaouel P, Malouf GG, Su X, Yao H, Tripathi DN, Soeung M, Gao J, Rao P, Coarfa C, Creighton CJ, Bertocchio JP, Kunnimalaiyaan S, Multani AS, Blando J, He R, ... ... Schlacher K, et al. Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma. Cancer Cell. PMID 32359397 DOI: 10.1016/J.Ccell.2020.04.002  0.345
2019 Roy S, Schlacher K. SIRF: A Single-cell Assay for Protein Interaction with Nascent DNA Replication Forks. Bio-Protocol. 9: e3377. PMID 33654873 DOI: 10.21769/BioProtoc.3377  0.458
2019 Lazarchuk P, Roy S, Schlacher K, Sidorova J. Detection and Quantitation of Acetylated Histones on Replicating DNA Using In Situ Proximity Ligation Assay and Click-It Chemistry. Methods in Molecular Biology (Clifton, N.J.). 1983: 29-45. PMID 31087291 DOI: 10.1007/978-1-4939-9434-2_3  0.429
2019 Ma S, Pradeep S, Villar-Prados A, Wen Y, Bayraktar E, Mangala LS, Kim MS, Wu SY, Hu W, Rodriguez-Aguayo C, Leuschner C, Liang X, Ram PT, Schlacher K, Coleman RL, et al. GnRH-R targeted lytic peptide sensitizes BRCA wild-type ovarian cancer to PARP inhibition. Molecular Cancer Therapeutics. PMID 30926640 DOI: 10.1158/1535-7163.Mct-18-0770  0.308
2019 Schlacher K. Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics. The Journal of Cell Biology. PMID 30782782 DOI: 10.1083/Jcb.201901050  0.35
2019 Roy S, Schlacher K. SIRF: A Single-cell Assay for in situ Protein Interaction with Nascent DNA Replication Forks Bio-Protocol. 9. DOI: 10.21769/bioprotoc.3377  0.459
2019 Galan-Cobo A, Pisegna M, Ramkumar K, Poteete A, Cho S, Zhang F, Fan Y, Wang Q, Diao L, Schlacher K, Wang J, Byers LA, Heymcach JV. Abstract A096: LKB1 deficiency and KEAP1/NRF2 pathway alterations as biomarkers of response for ATR and ATM inhibitors and other inhibitors of DNA damage response (DDR) in NSCLC Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-A096  0.391
2018 Roy S, Luzwick JW, Schlacher K. SIRF: Quantitative in situ analysis of protein interactions at DNA replication forks. The Journal of Cell Biology. PMID 29572381 DOI: 10.1083/Jcb.20170912103212018C  0.489
2018 Roy S, Luzwick JW, Schlacher K. SIRF: Quantitative in situ analysis of protein interactions at DNA replication forks. The Journal of Cell Biology. PMID 29475976 DOI: 10.1083/Jcb.201709121  0.572
2018 Roy S, Tomaszowski KH, Luzwick JW, Park S, Li J, Murphy M, Schlacher K. p53 suppresses mutagenic RAD52 and POLθ pathways by orchestrating DNA replication restart homeostasis. Elife. 7. PMID 29334356 DOI: 10.7554/Elife.31723  0.508
2017 Gadhikar MA, Zhang J, Shen L, Rao X, Wang J, Zhao M, Kalu NN, Johnson FM, Byers LA, Heymach J, Hittelman WN, Udayakumar D, Pandita RK, Pandita TK, Pickering CR, ... ... Schlacher K, et al. CDKN2A/p16 deletion in head and neck cancer cells is associated with Cdk2 activation, replication stress, and vulnerability to Chk1 inhibition. Cancer Research. PMID 29229598 DOI: 10.1158/0008-5472.Can-17-2802  0.369
2017 Schlacher K. PARPi focus the spotlight on replication fork protection in cancer. Nature Cell Biology. 19: 1309-1310. PMID 29087384 DOI: 10.1038/Ncb3638  0.571
2017 Tian Y, Shen X, Wang R, Klages-Mundt N, Lynn EJ, Martin SK, Ye Y, Gao M, Chen J, Schlacher K, Li L. Constitutive role of the Fanconi anemia D2 gene in the replication stress response. The Journal of Biological Chemistry. PMID 29021208 DOI: 10.1074/Jbc.M117.814780  0.497
2017 Xu S, Wu X, Wu L, Castillo A, Liu J, Atkinson E, Paul A, Su D, Schlacher K, Komatsu Y, You MJ, Wang B. Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes & Development. 31: 1469-1482. PMID 28860160 DOI: 10.1101/Gad.299172.117  0.513
2017 Schlacher K, Roy S, Tomaszowski K. Abstract LB-263: P53 promotes replication genome stability by epigenetics-enabled MRE11 restart Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-263  0.443
2016 Liu W, Zhou M, Li Z, Li H, Polaczek P, Dai H, Wu Q, Liu C, Karanja KK, Popuri V, Shan SO, Schlacher K, Zheng L, Campbell JL, Shen B. A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy. Ebiomedicine. 6: 73-86. PMID 27211550 DOI: 10.1016/J.Ebiom.2016.02.043  0.586
2016 Liu W, Zhou M, Li Z, Li H, Polaczek P, Dai H, Wu Q, Liu C, Karanja KK, Popuri V, Shan So, Schlacher K, Zheng L, Campbell JL, Shen B. A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy Ebiomedicine. DOI: 10.1016/j.ebiom.2016.02.043  0.308
2015 Guo C, Kumagai A, Schlacher K, Shevchenko A, Shevchenko A, Dunphy WG. Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication. Molecular Cell. 57: 492-505. PMID 25557548 DOI: 10.1016/J.Molcel.2014.12.003  0.505
2012 Schlacher K, Wu H, Jasin M. A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell. 22: 106-16. PMID 22789542 DOI: 10.1016/J.Ccr.2012.05.015  0.469
2011 Siaud N, Barbera MA, Egashira A, Lam I, Christ N, Schlacher K, Xia B, Jasin M. Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains. Plos Genetics. 7: e1002409. PMID 22194698 DOI: 10.1371/Journal.Pgen.1002409  0.5
2011 Schlacher K, Christ N, Siaud N, Egashira A, Wu H, Jasin M. Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell. 145: 529-42. PMID 21565612 DOI: 10.1016/J.Cell.2011.03.041  0.562
2011 Schlacher K, Christ N, Siaud N, Egashira A, Wu H, Jasin M. Erratum: Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11 (Cell (2011) 145 (529-542)) Cell. 145. DOI: 10.1016/J.Cell.2011.05.021  0.491
2007 Schlacher K, Goodman MF. Lessons from 50 years of SOS DNA-damage-induced mutagenesis. Nature Reviews. Molecular Cell Biology. 8: 587-94. PMID 17551516 DOI: 10.1038/Nrm2198  0.647
2006 Schlacher K, Cox MM, Woodgate R, Goodman MF. RecA acts in trans to allow replication of damaged DNA by DNA polymerase V. Nature. 442: 883-7. PMID 16929290 DOI: 10.1038/Nature05042  0.661
2006 Schlacher K, Jiang Q, Woodgate R, Goodman MF. Purification and characterization of Escherichia coli DNA polymerase V. Methods in Enzymology. 408: 378-90. PMID 16793381 DOI: 10.1016/S0076-6879(06)08023-2  0.679
2006 Schlacher K, Pham P, Cox MM, Goodman MF. Roles of DNA polymerase V and RecA protein in SOS damage-induced mutation. Chemical Reviews. 106: 406-19. PMID 16464012 DOI: 10.1021/Cr0404951  0.633
2005 Schlacher K, Leslie K, Wyman C, Woodgate R, Cox MM, Goodman MF. DNA polymerase V and RecA protein, a minimal mutasome. Molecular Cell. 17: 561-72. PMID 15721259 DOI: 10.1016/J.Molcel.2005.01.006  0.619
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