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Luz D. Orozco, Ph.D. - Publications

Affiliations: 
2011 University of California, Los Angeles, Los Angeles, CA 
Area:
Genetics, Bioinformatics Biology, Systematic Biology
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28/50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 den Hollander AI, Mullins RF, Orozco LD, Voigt AP, Chen HH, Strunz T, Grassmann F, Haines JL, Kuiper JJW, Tumminia SJ, Allikmets R, Hageman GS, Stambolian D, Klaver CCW, Boeke JD, et al. Systems genomics in age-related macular degeneration. Experimental Eye Research. 109248. PMID 36108770 DOI: 10.1016/j.exer.2022.109248  0.381
2019 Bhetraratana M, Orozco LD, Hong J, Diamante G, Majid S, Bennett BJ, Ahn IS, Yang X, Lusis AJ, Araujo JA. Diesel exhaust particles dysregulate multiple immunological pathways in murine macrophages: Lessons from microarray and scRNA-seq technologies. Archives of Biochemistry and Biophysics. 108116. PMID 31568751 DOI: 10.1016/J.Abb.2019.108116  0.702
2018 Orozco LD, Farrell C, Hale C, Rubbi L, Rinaldi A, Civelek M, Pan C, Lam L, Montoya D, Edillor C, Seldin M, Boehnke M, Mohlke KL, Jacobsen S, Kuusisto J, et al. Epigenome-wide association in adipose tissue from the METSIM cohort. Human Molecular Genetics. PMID 29893869 DOI: 10.1093/Hmg/Ddy205  0.42
2018 Orozco LD, Farrell C, Hale C, Rbi L, Rinaldi A, Civelek M, Pan C, Lam L, Montoya D, Edillor C, Seldin M, Mohlke KL, Jacobsen S, Kuusisto J, Laakso M, et al. Epigenome-wide association in adipose tissue from the METSIM cohort. Human Molecular Genetics. PMID 29566149 DOI: 10.1093/Hmg/Ddy093  0.517
2017 Lupu DS, Orozco LD, Wang Y, Cullen JM, Pellegrini M, Zeisel SH. Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28179424 DOI: 10.1096/Fj.201601169R  0.458
2016 Shu L, Zhao Y, Kurt Z, Byars SG, Tukiainen T, Kettunen J, Orozco LD, Pellegrini M, Lusis AJ, Ripatti S, Zhang B, Inouye M, Mäkinen VP, Yang X. Mergeomics: multidimensional data integration to identify pathogenic perturbations to biological systems. Bmc Genomics. 17: 874. PMID 27814671 DOI: 10.1186/S12864-016-3198-9  0.431
2016 Meng Q, Ying Z, Noble E, Zhao Y, Agrawal R, Mikhail A, Zhuang Y, Tyagi E, Zhang Q, Lee JH, Morselli M, Orozco L, Guo W, Kilts TM, Zhu J, et al. Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders. Ebiomedicine. 7: 157-166. PMID 27322469 DOI: 10.1016/J.Ebiom.2016.04.008  0.376
2016 Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Sevag Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, et al. Correction: Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. Plos Genetics. 12: e1005913. PMID 26934746 DOI: 10.1371/journal.pgen.1005913  0.494
2016 Chen H, Orozco LD, Wang J, Rau CD, Rubbi L, Ren S, Wang Y, Pellegrini M, Lusis AJ, Vondriska TM. DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States. Circulation Research. PMID 26838786 DOI: 10.1161/Circresaha.115.305298  0.661
2015 Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, et al. Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. Plos Genetics. 11: e1005711. PMID 26694027 DOI: 10.1371/Journal.Pgen.1005711  0.646
2015 Orozco LD, Morselli M, Rubbi L, Guo W, Go J, Shi H, Lopez D, Furlotte NA, Bennett BJ, Farber CR, Ghazalpour A, Zhang MQ, Bahous R, Rozen R, Lusis AJ, et al. Epigenome-wide association of liver methylation patterns and complex metabolic traits in mice. Cell Metabolism. 21: 905-17. PMID 26039453 DOI: 10.1016/J.Cmet.2015.04.025  0.748
2014 Orozco LD, Rubbi L, Martin LJ, Fang F, Hormozdiari F, Che N, Smith AD, Lusis AJ, Pellegrini M. Intergenerational genomic DNA methylation patterns in mouse hybrid strains. Genome Biology. 15: R68. PMID 24887417 DOI: 10.1186/Gb-2014-15-5-R68  0.571
2014 Ghazalpour A, Bennett BJ, Shih D, Che N, Orozco L, Pan C, Hagopian R, He A, Kayne P, Yang WP, Kirchgessner T, Lusis AJ. Genetic regulation of mouse liver metabolite levels. Molecular Systems Biology. 10: 730. PMID 24860088 DOI: 10.15252/Msb.20135004  0.769
2013 Heinz S, Romanoski CE, Benner C, Allison KA, Kaikkonen MU, Orozco LD, Glass CK. Effect of natural genetic variation on enhancer selection and function. Nature. 503: 487-92. PMID 24121437 DOI: 10.1038/Nature12615  0.688
2013 Chen PY, Ganguly A, Rubbi L, Orozco LD, Morselli M, Ashraf D, Jaroszewicz A, Feng S, Jacobsen SE, Nakano A, Devaskar SU, Pellegrini M. Intrauterine calorie restriction affects placental DNA methylation and gene expression. Physiological Genomics. 45: 565-76. PMID 23695884 DOI: 10.1152/Physiolgenomics.00034.2013  0.44
2013 Rau CD, Wisniewski N, Orozco LD, Bennett B, Weiss J, Lusis AJ. Maximal information component analysis: a novel non-linear network analysis method. Frontiers in Genetics. 4: 28. PMID 23487572 DOI: 10.3389/Fgene.2013.00028  0.648
2013 Davis RC, van Nas A, Bennett B, Orozco L, Pan C, Rau CD, Eskin E, Lusis AJ. Genome-wide association mapping of blood cell traits in mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 24: 105-18. PMID 23417284 DOI: 10.1007/S00335-013-9448-0  0.78
2012 Calabrese G, Bennett BJ, Orozco L, Kang HM, Eskin E, Dombret C, De Backer O, Lusis AJ, Farber CR. Systems genetic analysis of osteoblast-lineage cells. Plos Genetics. 8: e1003150. PMID 23300464 DOI: 10.1371/Journal.Pgen.1003150  0.583
2012 Orozco LD, Bennett BJ, Farber CR, Ghazalpour A, Pan C, Che N, Wen P, Qi HX, Mutukulu A, Siemers N, Neuhaus I, Yordanova R, Gargalovic P, Pellegrini M, Kirchgessner T, et al. Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell. 151: 658-70. PMID 23101632 DOI: 10.1016/J.Cell.2012.08.043  0.75
2012 Kim JB, Deluna A, Mungrue IN, Vu C, Pouldar D, Civelek M, Orozco L, Wu J, Wang X, Charugundla S, Castellani LW, Rusek M, Jakubowski H, Jakobowski H, Lusis AJ. Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice. Circulation. 126: 1896-906. PMID 22952318 DOI: 10.1161/Circulationaha.111.064881  0.556
2012 Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, et al. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 23: 680-92. PMID 22892838 DOI: 10.1007/S00335-012-9411-5  0.745
2012 Bennett BJ, Orozco L, Kostem E, Erbilgin A, Dallinga M, Neuhaus I, Guan B, Wang X, Eskin E, Lusis AJ. High-resolution association mapping of atherosclerosis loci in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 1790-8. PMID 22723443 DOI: 10.1161/Atvbaha.112.253864  0.781
2011 Ghazalpour A, Bennett B, Petyuk VA, Orozco L, Hagopian R, Mungrue IN, Farber CR, Sinsheimer J, Kang HM, Furlotte N, Park CC, Wen PZ, Brewer H, Weitz K, Camp DG, et al. Comparative analysis of proteome and transcriptome variation in mouse. Plos Genetics. 7: e1001393. PMID 21695224 DOI: 10.1371/Journal.Pgen.1001393  0.732
2011 Farber CR, Bennett BJ, Orozco L, Zou W, Lira A, Kostem E, Kang HM, Furlotte N, Berberyan A, Ghazalpour A, Suwanwela J, Drake TA, Eskin E, Wang QT, Teitelbaum SL, et al. Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. Plos Genetics. 7: e1002038. PMID 21490954 DOI: 10.1371/Journal.Pgen.1002038  0.752
2011 Barajas B, Che N, Yin F, Rowshanrad A, Orozco LD, Gong KW, Wang X, Castellani LW, Reue K, Lusis AJ, Araujo JA. NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 58-66. PMID 20947826 DOI: 10.1161/Atvbaha.110.210906  0.61
2010 Bennett BJ, Farber CR, Orozco L, Kang HM, Ghazalpour A, Siemers N, Neubauer M, Neuhaus I, Yordanova R, Guan B, Truong A, Yang WP, He A, Kayne P, Gargalovic P, et al. A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Research. 20: 281-90. PMID 20054062 DOI: 10.1101/Gr.099234.109  0.76
2009 Orozco LD, Cokus SJ, Ghazalpour A, Ingram-Drake L, Wang S, van Nas A, Che N, Araujo JA, Pellegrini M, Lusis AJ. Copy number variation influences gene expression and metabolic traits in mice. Human Molecular Genetics. 18: 4118-29. PMID 19648292 DOI: 10.1093/Hmg/Ddp360  0.746
2007 Orozco LD, Kapturczak MH, Barajas B, Wang X, Weinstein MM, Wong J, Deshane J, Bolisetty S, Shaposhnik Z, Shih DM, Agarwal A, Lusis AJ, Araujo JA. Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis. Circulation Research. 100: 1703-11. PMID 17495224 DOI: 10.1161/Circresaha.107.151720  0.646
Low-probability matches (unlikely to be authored by this person)
2020 Orozco LD, Chen HH, Cox C, Katschke KJ, Arceo R, Espiritu C, Caplazi P, Nghiem SS, Chen YJ, Modrusan Z, Dressen A, Goldstein LD, Clarke C, Bhangale T, Yaspan B, et al. Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration. Cell Reports. 30: 1246-1259.e6. PMID 31995762 DOI: 10.1016/J.Celrep.2019.12.082  0.28
2023 Orozco LD, Owen LA, Hofmann J, Stockwell AD, Tao J, Haller S, Mukundan VT, Clarke C, Lund J, Sridhar A, Mayba O, Barr JL, Zavala RA, Graves EC, Zhang C, et al. A systems biology approach uncovers novel disease mechanisms in age-related macular degeneration. Cell Genomics. 3: 100302. PMID 37388919 DOI: 10.1016/j.xgen.2023.100302  0.278
2016 Meng Q, Ying Z, Noble E, Zhao Y, Agrawal R, Mikhail A, Zhuang Y, Tyagi E, Zhang Q, Lee JH, Morselli M, Orozco L, Guo W, Kilts TM, Zhu J, et al. Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders Ebiomedicine. DOI: 10.1016/j.ebiom.2016.04.008  0.256
2016 Nagarkar D, Manzanillo P, Ichikawa R, Rae J, Orozco L, Hackney J, Herman A, Keir M. Sa1826 Identification of Gene Signatures in Human Intestinal Organoids for Biomarker Analyses Gastroenterology. 150: S374. DOI: 10.1016/S0016-5085(16)31315-4  0.217
2023 Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, et al. A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling. Iscience. 26: 107813. PMID 37810211 DOI: 10.1016/j.isci.2023.107813  0.175
2023 Orozco LD, Chen HH, Cox C, Katschke KJ, Espiritu C, Caplazi P, Nghiem SS, Chen YJ, Modrusan Z, Dressen A, Goldstein LD, Clarke C, Bhangale T, Yaspan B, Jeanne M, et al. Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration. Cell Reports. 42: 112298. PMID 36952338 DOI: 10.1016/j.celrep.2023.112298  0.169
2023 Jones MK, Orozco LD, Qin H, Truong T, Caplazi P, Elstrott J, Modrusan Z, Chaney SY, Jeanne M. Integration of human stem cell-derived systems and mouse preclinical models identifies complex pathophysiologic mechanisms in retinal dystrophy. Frontiers in Cell and Developmental Biology. 11: 1252547. PMID 37691820 DOI: 10.3389/fcell.2023.1252547  0.165
2016 Ichikawa R, Eastham-Anderson J, Scherl A, Hackney J, Orozco L, Faubion W, Mansfield J, Kirby J, Lamb C, Keir M. Sa1947 αE+ Cells Have Increased Expression of Inflammatory Markers and Are Correlated in the Ileum and Colon Gastroenterology. 150: S413. DOI: 10.1016/S0016-5085(16)31435-4  0.165
2021 Dai B, Hackney JA, Ichikawa R, Nguyen A, Elstrott J, Orozco LD, Sun KH, Modrusan Z, Gogineni A, Scherl A, Gubatan J, Habtezion A, Deswal M, Somsouk M, Faubion WA, et al. Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease. Cell Reports. Medicine. 2: 100381. PMID 34467254 DOI: 10.1016/j.xcrm.2021.100381  0.156
2022 Yaghy A, Lee AY, Keane PA, Keenan TDL, Mendonca LSM, Lee CS, Cairns AM, Caroll J, Chen H, Clark J, Cukras CA, de Sisternes L, Domalpally A, Durbin MK, Goetz KE, ... ... Orozco LD, et al. Artificial intelligence-based strategies to identify patient populations and advance analysis in age-related macular degeneration clinical trials. Experimental Eye Research. 109092. PMID 35525297 DOI: 10.1016/j.exer.2022.109092  0.085
2019 Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, ... ... Orozco LD, et al. An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma. Cell. 179: 417-431.e19. PMID 31585081 DOI: 10.1016/J.Cell.2019.09.009  0.082
2013 Orozco LD, Liu H, Perkins E, Johnson DA, Chen BB, Fan F, Baker RC, Roman RJ. 20-Hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries. The Journal of Pharmacology and Experimental Therapeutics. 346: 67-74. PMID 23658377 DOI: 10.1124/jpet.113.203844  0.07
2011 Orozco LD, Khan MA, Fratkin JD, Hanigan WC. Asymptomatic aneurysm of the cavernous and supraclinoid internal carotid artery in a patient with Balamuthia mandrillaris encephalitis. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 18: 1118-20. PMID 21652212 DOI: 10.1016/J.Jocn.2010.11.033  0.063
2013 Orozco LD, Stacy JD, Luqman AW, Buciuc RF, Luzardo GD. Carotid cavernous fistulae occurring after the use of the Fogarty catheter in carotid surgery: a review. Vascular and Endovascular Surgery. 47: 359-67. PMID 23867784 DOI: 10.1177/1538574413487440  0.063
2011 Orozco LD, Liu H, Chen BB, Fratkin JD, Perkins E. Angiographic evaluation of the rat carotid balloon injury model. Experimental and Molecular Pathology. 91: 590-5. PMID 21798260 DOI: 10.1016/J.Yexmp.2011.06.011  0.057
2017 Nagarkar D, Harder B, Deswal M, Orozco L, Ramamoorthi N, Loyet K, Erickson R, Faubion W, Lu T, Lekkerkerker AN, Somsouk M, Keir M. REG3A is Induced in Response to IL-22 and Correlated with Peripheral IL-22 Levels in Subjects with Inflammatory Bowel Disease Gastroenterology. 152: S965. DOI: 10.1016/S0016-5085(17)33275-4  0.055
2012 Orozco LD, Liu H, Chen BB, Buciuc RF, Fratkin JD, Pisarello JC, Perkins E. Aortic response to balloon injury in obese Zucker rats. Comparative Medicine. 62: 264-70. PMID 23043778  0.044
2023 Wagner F, Mansfield JC, Lekkerkerker AN, Wang Y, Keir M, Dash A, Butcher B, Harder B, Orozco LD, Mar JS, Chen H, Rothenberg ME. Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis. Gut. PMID 36732049 DOI: 10.1136/gutjnl-2022-328387  0.043
2020 Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, ... ... Orozco LD, et al. An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma. Cell. 180: 406. PMID 31978350 DOI: 10.1016/j.cell.2020.01.003  0.032
2013 Orozco LD, Luzardo GD, Buciuc RF. Transarterial balloon assisted Onyx embolization of pericallosal arteriovenous malformations. Journal of Neurointerventional Surgery. 5: e18. PMID 22730338 DOI: 10.1136/neurintsurg-2012-010388  0.028
2012 Orozco LD, Buciuc RF, Parent AD. Endovascular embolization of prominent intercavernous sinuses for successful transsphenoidal resection of Cushing microadenoma: case report. Neurosurgery. 71: 204-8. PMID 22562086 DOI: 10.1227/NEU.0b013e31825b1eac  0.019
2011 Orozco LD, Tiel RL. Exophytic ependymoma of the thoracic spine. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 18: 1262-4. PMID 21742501 DOI: 10.1016/j.jocn.2011.01.017  0.016
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