| Year |
Citation |
Score |
| 2022 |
Weng CC, Riad A, Lieberman BP, Xu K, Peng X, Mikitsh JL, Mach RH. Characterization of Sigma-2 Receptor-Specific Binding Sites Using [H]DTG and [I]RHM-4. Pharmaceuticals (Basel, Switzerland). 15. PMID 36559015 DOI: 10.3390/ph15121564 |
0.42 |
|
| 2020 |
Ferrie JJ, Lengyel-Zhand Z, Janssen B, Lougee MG, Giannakoulias S, Hsieh CJ, Pagar VV, Weng CC, Xu H, Graham TJA, Lee VM, Mach RH, Petersson EJ. Identification of a nanomolar affinity α-synuclein fibril imaging probe by ultra-high throughput screening. Chemical Science. 11: 12746-12754. PMID 33889379 DOI: 10.1039/D0Sc02159H |
0.346 |
|
| 2020 |
Ågren R, Zeberg H, Maciej Stępniewski T, Free RB, Reilly SW, Luedtke RR, Århem P, Ciruela F, Sibley DR, Mach RH, Selent J, Nilsson J, Sahlholm K. A ligand with two modes of interaction with the dopamine D2 receptor - An induced-fit mechanism of insurmountable antagonism. Acs Chemical Neuroscience. PMID 32865974 DOI: 10.1021/Acschemneuro.0C00477 |
0.37 |
|
| 2020 |
Zeng C, Riad A, Mach RH. The Biological Function of Sigma-2 Receptor/TMEM97 and Its Utility in PET Imaging Studies in Cancer. Cancers. 12. PMID 32668577 DOI: 10.3390/Cancers12071877 |
0.362 |
|
| 2020 |
Riad A, Lengyel-Zhand Z, Zeng C, Weng CC, Lee VM, Trojanowski JQ, Mach RH. The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates. Molecular Neurobiology. PMID 32572762 DOI: 10.1007/S12035-020-01988-1 |
0.333 |
|
| 2019 |
McDonald ES, Doot RK, Young AJ, Schubert EK, Pryma DA, Farwell MD, Tchou J, Nayak A, Ziober A, Feldman MD, DeMichele A, Clark AS, Shah PD, Lee H, Carlin SD, ... Mach RH, et al. Breast Cancer F-ISO-1 Uptake as a Marker of Proliferation Status. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 31836680 DOI: 10.2967/Jnumed.119.232363 |
0.354 |
|
| 2019 |
Lee H, Riad A, Martorano P, Mansfield A, Samanta M, Batra V, Mach RH, Maris JM, Pryma DA, Makvandi M. PARP-1-targeted Auger emitters display high-LET cytotoxic properties in vitro but show limited therapeutic utility in solid tumor models of human neuroblastoma. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 31676730 DOI: 10.2967/Jnumed.119.233965 |
0.305 |
|
| 2019 |
Sellmyer MA, Richman SA, Lohith K, Hou C, Weng CC, Mach RH, O'Connor RS, Milone MC, Farwell MD. Imaging CAR T Cell Trafficking with eDFHR as a PET Reporter Gene. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 31668558 DOI: 10.1016/J.Ymthe.2019.10.007 |
0.346 |
|
| 2019 |
Janssen B, Mach RH. Development of brain PET imaging agents: Strategies for imaging neuroinflammation in Alzheimer's disease. Progress in Molecular Biology and Translational Science. 165: 371-399. PMID 31481170 DOI: 10.1016/Bs.Pmbts.2019.04.005 |
0.335 |
|
| 2019 |
Chen PJ, Taylor M, Griffin SA, Amani A, Hayatshahi H, Korzekwa K, Ye M, Mach RH, Liu J, Luedtke RR, Gordon JC, Blass BE. Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D receptor ligands. Bioorganic & Medicinal Chemistry Letters. PMID 31387791 DOI: 10.1016/J.Bmcl.2019.07.020 |
0.385 |
|
| 2019 |
Weng CC, Carlin S, Hou C, Metz T, Li S, Lee H, Xu K, Makvandi M, Mach RH. Correlation analysis of [F]ROStrace using ex vivo autoradiography and dihydroethidium fluorescent imaging in lipopolysaccharide-treated animals. Biochemical and Biophysical Research Communications. PMID 31221481 DOI: 10.1016/J.Bbrc.2019.06.062 |
0.338 |
|
| 2019 |
Reilly SW, Riad AA, Hsieh CJ, Sahlholm K, Jacome DA, Griffin S, Taylor M, Weng CC, Xu K, Kirschner N, Luedtke RR, Parry C, Malhotra S, Karanicolas J, Mach RH. Leveraging a Low Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D3 Receptor (D3R) Ligand Promiscuity Across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs). Journal of Medicinal Chemistry. PMID 31021617 DOI: 10.1021/Acs.Jmedchem.9B00412 |
0.398 |
|
| 2019 |
Zeng C, Weng CC, Schneider ME, Puentes L, Riad A, Xu K, Makvandi M, Jin L, Hawkins WG, Mach RH. TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death. Cell Death Discovery. 5: 58. PMID 30701090 DOI: 10.1038/S41420-019-0141-2 |
0.359 |
|
| 2019 |
Elmi A, Makvandi M, Weng CC, Hou C, Clark AS, Mach RH, Mankoff DA. Cell-proliferation imaging for monitoring response to CDK4/6 inhibition combined with endocrine-therapy in breast cancer: Comparison of [F]FLT and [F]ISO-1 PET/CT. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30692100 DOI: 10.1158/1078-0432.Ccr-18-2769 |
0.346 |
|
| 2019 |
McDonald E, Carlin S, Maxwell K, Nayak A, Doot R, Pantel A, Farwell, Pryma D, Clark A, Shah P, DeMichele A, Ziober A, Schubert E, Palmer K, Lee H, ... ... Mach R, et al. Abstract PD4-07: PET imaging of PARP-1 expression in breast cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Sabcs18-Pd4-07 |
0.353 |
|
| 2018 |
Riad A, Zeng C, Weng CC, Winters H, Xu K, Makvandi M, Metz T, Carlin S, Mach RH. Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex. Scientific Reports. 8: 16845. PMID 30443021 DOI: 10.1038/S41598-018-35430-3 |
0.345 |
|
| 2018 |
Reilly SW, Puentes LN, Schmitz A, Hsieh CJ, Weng CC, Hou C, Li S, Kuo YM, Padakanti P, Lee H, Riad AA, Makvandi M, Mach RH. Synthesis and evaluation of an AZD2461 [F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant. Bioorganic Chemistry. 83: 242-249. PMID 30390553 DOI: 10.1016/J.Bioorg.2018.10.015 |
0.351 |
|
| 2018 |
Powell GL, Bonadonna JP, Vannan A, Mach RH, Luedtke RR, Neisewander JL. Dopamine D3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors. Pharmacology, Biochemistry, and Behavior. PMID 30308214 DOI: 10.1016/J.Pbb.2018.10.002 |
0.352 |
|
| 2018 |
Hayatshahi HS, Xu K, Griffin SA, Taylor M, Mach RH, Liu J, Luedtke RR. Analogs of Arylamide Phenylpiperazine Ligands to Investigate the Factors Influencing D3 Dopamine Receptor Bitropic Binding and Receptor Subtype Selectivity. Acs Chemical Neuroscience. PMID 30010318 DOI: 10.1021/Acschemneuro.8B00142 |
0.385 |
|
| 2018 |
Powell GL, Bonadonna JP, Vannan A, Xu K, Mach RH, Luedtke RR, Neisewander JL. Dopamine Ds3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors. Pharmacology, Biochemistry, and Behavior. PMID 29807065 DOI: 10.1016/J.Pbb.2018.05.015 |
0.351 |
|
| 2018 |
Doot RK, Dubroff JG, Labban KJ, Mach RH. Selectivity of probes for PET imaging of dopamine D3 receptors. Neuroscience Letters. PMID 29518538 DOI: 10.1016/J.Neulet.2018.03.006 |
0.375 |
|
| 2018 |
Janssen B, Vugts DJ, Windhorst AD, Mach RH. PET Imaging of Microglial Activation-Beyond Targeting TSPO. Molecules (Basel, Switzerland). 23. PMID 29518005 DOI: 10.3390/Molecules23030607 |
0.321 |
|
| 2018 |
Makvandi M, Pantel A, Schwartz L, Schubert E, Xu K, Hsieh CJ, Hou C, Kim H, Weng CC, Winters H, Doot R, Farwell MD, Pryma DA, Greenberg RA, Mankoff DA, ... ... Mach RH, et al. A PET imaging agent for evaluating PARP-1 expression in ovarian cancer. The Journal of Clinical Investigation. PMID 29509546 DOI: 10.1172/Jci97992 |
0.313 |
|
| 2018 |
Yue X, Dhavale DD, Li J, Luo Z, Liu J, Yang H, Mach RH, Kotzbauer PT, Tu Z. Design, synthesis, and in vitro evaluation of quinolinyl analogues for α-synuclein aggregation. Bioorganic & Medicinal Chemistry Letters. PMID 29482941 DOI: 10.1016/J.Bmcl.2018.02.031 |
0.308 |
|
| 2018 |
Makvandi M, Pantel A, Schwartz L, Doot R, Simpkins F, Mankoff DA, Mach RH, Lin L. Abstract A054: Real-time imaging of PARP-1 in ovarian cancer Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-A054 |
0.363 |
|
| 2017 |
Li S, Schmitz A, Lee H, Mach RH. Automation of the Radiosynthesis of Six DifferentF-labeled radiotracers on the AllinOne. Ejnmmi Radiopharmacy and Chemistry. 1: 15. PMID 29564391 DOI: 10.1186/S41181-016-0018-0 |
0.306 |
|
| 2017 |
Sun YT, Wang GF, Yang YQ, Jin F, Wang Y, Xie XY, Mach RH, Huang YS. Synthesis and pharmacological evaluation of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as sigma-2 receptor ligands. European Journal of Medicinal Chemistry. 147: 227-237. PMID 29438891 DOI: 10.1016/J.Ejmech.2017.11.016 |
0.431 |
|
| 2017 |
Makvandi M, Sellmyer MA, Mach RH. Inflammation and DNA damage: Probing pathways to cancer and neurodegeneration. Drug Discovery Today. Technologies. 25: 37-43. PMID 29233266 DOI: 10.1016/J.Ddtec.2017.11.001 |
0.307 |
|
| 2017 |
Reilly SW, Griffin S, Taylor M, Sahlholm K, Weng CC, Xu K, Jacome DA, Luedtke RR, Mach RH. Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores. Journal of Medicinal Chemistry. PMID 29125762 DOI: 10.1021/Acs.Jmedchem.7B01248 |
0.398 |
|
| 2017 |
Hou C, Hsieh CJ, Li S, Lee H, Graham TJA, Xu K, Weng CC, Doot RK, Chu W, Chakraborty SK, Dugan LL, Mintun MA, Mach R. Development of a PET Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation. Acs Chemical Neuroscience. PMID 29099578 DOI: 10.1021/Acschemneuro.7B00385 |
0.332 |
|
| 2017 |
Mach RH, Luedtke RR. Challenges in the Development of Dopamine D2- and D3-selective Radiotracers for PET Imaging Studies. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 28857231 DOI: 10.1002/Jlcr.3558 |
0.406 |
|
| 2017 |
Mach RH. Small Molecule Receptor Ligands for PET Studies of the Central Nervous System-Focus on G Protein Coupled Receptors. Seminars in Nuclear Medicine. 47: 524-535. PMID 28826524 DOI: 10.1053/J.Semnuclmed.2017.05.002 |
0.391 |
|
| 2017 |
Sahlholm K, Ielacqua GD, Xu J, Jones LA, Schlegel F, Mach RH, Rudin M, Schroeter A. The role of beta-arrestin2 in shaping fMRI BOLD responses to dopaminergic stimulation. Psychopharmacology. PMID 28382543 DOI: 10.1007/S00213-017-4609-6 |
0.324 |
|
| 2017 |
McDonald ES, Mankoff J, Makvandi M, Chu W, Chu Y, Mach RH, Zeng C. Sigma-2 ligands and PARP inhibitors synergistically trigger cell death in breast cancer cells. Biochemical and Biophysical Research Communications. PMID 28347815 DOI: 10.1016/J.Bbrc.2017.03.122 |
0.35 |
|
| 2017 |
Zeng C, Mach RH. The Evolution of the Sigma-2 (σ2) Receptor from Obscure Binding Site to Bona Fide Therapeutic Target. Advances in Experimental Medicine and Biology. 964: 49-61. PMID 28315264 DOI: 10.1007/978-3-319-50174-1_5 |
0.376 |
|
| 2017 |
Zhou R, Pantel AR, Li S, Lieberman BP, Ploessl K, Choi H, Blankemeyer E, Lee H, Kung H, Mach RH, Mankoff D. [18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple Negative Breast Cancer in Response to Glutaminase Inhibition. Cancer Research. PMID 28202527 DOI: 10.1158/0008-5472.Can-16-1945 |
0.347 |
|
| 2017 |
Zeng C, McDonald ES, Mach RH. Molecular Probes for Imaging the Sigma-2 Receptor: In Vitro and In Vivo Imaging Studies. Handbook of Experimental Pharmacology. PMID 28176045 DOI: 10.1007/164_2016_96 |
0.428 |
|
| 2017 |
Yang D, Comeau A, Bowen WD, Mach RH, Ross BD, Hong H, Van Dort ME. Design and Investigation of a [18F]-labeled Benzamide Derivative as a High Affinity Dual Sigma Receptor Subtype Radioligand for Prostate Tumor Imaging. Molecular Pharmaceutics. PMID 28135101 DOI: 10.1021/Acs.Molpharmaceut.6B01020 |
0.4 |
|
| 2017 |
Sellmyer MA, Lee I, Hou C, Lieberman BP, Zeng C, Mankoff DA, Mach RH. Quantitative PET Reporter Gene Imaging with [(11)C]Trimethoprim. Molecular Therapy : the Journal of the American Society of Gene Therapy. 25: 120-126. PMID 28129108 DOI: 10.1016/J.Ymthe.2016.10.018 |
0.322 |
|
| 2017 |
Hashim YM, Vangveravong S, Sankpal NV, Binder PS, Liu J, Goedegebuure SP, Mach RH, Spitzer D, Hawkins WG. The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer. Journal of Experimental & Clinical Cancer Research : Cr. 36: 14. PMID 28095907 DOI: 10.1186/S13046-016-0470-4 |
0.313 |
|
| 2017 |
Jin LX, Vangveravong S, Cullinan DR, Goedegebuure PS, Loza AJ, Mach RH, Spitzer D, Hawkins WG. Targeted pancreatic cancer drug-delivery utilizing sigma-2 ligand/receptor internalization is energy-dependent. Journal of Clinical Oncology. 35: 331-331. DOI: 10.1200/Jco.2017.35.4_Suppl.331 |
0.369 |
|
| 2017 |
Lin L, Makvandi M, Pantel A, Doot R, Schwartz L, Simpkins F, Mankoff D, Mach R. Abstract AP20: A PILOT STUDY OF A POLY (ADP–RIBOSE) POLYMERASE–1 (PARP) TARGETED NOVEL PET TRACER (18F–FLUOURTHANOTRACE) IN PATIENTS WITH OVARIAN CARCINOMA Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Ovcasymp16-Ap20 |
0.341 |
|
| 2017 |
Makvandi M, Hou C, Xu K, Anderson R, Ander-Effron S, Mach RH, Maris JM, Pryma DA. Abstract B31: Poly(ADP-ribose) Polymerase 1 as a novel target for alpha-particle therapy in high-risk neuroblastoma Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-B31 |
0.302 |
|
| 2017 |
Puentes L, Xu K, Hou C, Mach RH, Maris JM, Pryma DA, Makvandi M. Abstract 5197: Targeting PARP-1 to deliver alpha-particles to cancer chromatin Cancer Research. 77: 5197-5197. DOI: 10.1158/1538-7445.Am2017-5197 |
0.306 |
|
| 2017 |
Bonadonna JP, Powell G, Carlson AK, Mendoza R, Mach RH, Luedtke RR, Neisewander JL. Effect of a dopamine D3 receptor partial agonist on cocaine-induced locomotion and self-administration Drug and Alcohol Dependence. 171: e23. DOI: 10.1016/J.Drugalcdep.2016.08.077 |
0.311 |
|
| 2016 |
Michel LS, Dyroff S, Brooks FJ, Spayd KJ, Lim S, Engle JT, Phillips S, Tan B, Wang-Gillam A, Bognar C, Chu W, Zhou D, Mach RH, Laforest R, Chen DL. PET of Poly (ADP-Ribose) Polymerase Activity in Cancer: Preclinical Assessment and First In-Human Studies. Radiology. 161929. PMID 27841728 DOI: 10.1148/Radiol.2016161929 |
0.318 |
|
| 2016 |
Conroy T, Manohar M, Gong Y, Wilkinson SM, Webster M, Lieberman BP, Banister SD, Reekie TA, Mach RH, Rendina LM, Kassiou M. A systematic exploration of the effects of flexibility and basicity on sigma (σ) receptor binding in a series of substituted diamines. Organic & Biomolecular Chemistry. 14: 9388-9405. PMID 27714195 DOI: 10.1039/C6Ob00615A |
0.332 |
|
| 2016 |
Song J, Wu Z, Wangtrakuldee P, Choi SR, Zha Z, Ploessl K, Mach RH, Kung HF. 4-(((4-Iodophenyl)methyl)-4H-1,2,4-triazol-4-ylamino)-benzonitrile: A potential imaging agent for aromatase. Journal of Medicinal Chemistry. PMID 27690428 DOI: 10.1021/Acs.Jmedchem.6B00849 |
0.349 |
|
| 2016 |
Lee I, Lieberman BP, Li S, Hou C, Makvandi M, Mach RH. Comparative evaluation of 4 and 6-carbon spacer conformationally flexible tetrahydroisoquinolinyl benzamide analogues for imaging the sigma-2 receptor status of solid tumors. Nuclear Medicine and Biology. 43: 721-731. PMID 27589334 DOI: 10.1016/J.Nucmedbio.2016.08.001 |
0.391 |
|
| 2016 |
Ikome HN, Ntie-Kang F, Ngemenya MN, Tu Z, Mach RH, Efange SM. 4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies. Chemistry Central Journal. 10: 53. PMID 27555879 DOI: 10.1186/S13065-016-0200-1 |
0.389 |
|
| 2016 |
Malik M, Rangel-Barajas C, Mach RH, Luedtke RR. The Effect of the Sigma-1 Receptor Selective Compound LS-1-137 on the DOI-Induced Head Twitch Response in Mice. Pharmacology, Biochemistry, and Behavior. PMID 27397487 DOI: 10.1016/J.Pbb.2016.07.001 |
0.387 |
|
| 2016 |
Makvandi M, Xu K, Lieberman BP, Anderson RC, Sander Effron S, Winters HD, Zeng C, McDonald ES, Pryma DA, Greenberg RA, Mach RH. A radiotracer strategy to quantify PARP-1 expression in vivo provides a biomarker that can enable patient selection for PARP inhibitor therapy. Cancer Research. PMID 27261505 DOI: 10.1158/0008-5472.Can-16-0416 |
0.317 |
|
| 2016 |
Ohman KA, Hashim YM, Vangveravong S, Nywening TM, Cullinan DR, Goedegebuure SP, Liu J, Van Tine BA, Tiriac H, Tuveson DA, DeNardo DG, Spitzer D, Mach RH, Hawkins WG. Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic. Oncotarget. PMID 27244881 DOI: 10.18632/Oncotarget.9551 |
0.342 |
|
| 2016 |
McDonald ES, Mankoff DA, Mach RH. Novel Strategies for Breast Cancer Imaging: New Imaging Agents to Guide Treatment. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 57: 69S-74S. PMID 26834105 DOI: 10.2967/Jnumed.115.157925 |
0.307 |
|
| 2016 |
Makvandi M, Lieberman BP, LeGeyt B, Hou C, Mankoff DA, Mach RH, Pryma DA. The pre-clinical characterization of an alpha-emitting sigma-2 receptor targeted radiotherapeutic. Nuclear Medicine and Biology. 43: 35-41. PMID 26702785 DOI: 10.1016/J.Nucmedbio.2015.10.001 |
0.374 |
|
| 2016 |
George E, Kim H, Tanyi J, Ragland R, Brown E, Zhang R, Brafford P, Sproesser K, Beqiri M, Vultur A, Krepler C, Weis B, Nathanson K, Lu Y, Mills G, ... ... Mach R, et al. Abstract A02: A novel orthotopic ovarian patient derived xenograft model platform to investigate novel therapies for BRCA deficient ovarian cancers Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-A02 |
0.318 |
|
| 2016 |
Edmonds C, Lieberman B, Xu K, Zeng C, Makvandi M, Li S, Hou C, Lee H, Greenberg R, Mankoff D, Mach R. Abstract P5-01-06:18F-radiolabeled PARP-1 inhibitor uptake as a marker of PARP-1 activity in breast cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P5-01-06 |
0.359 |
|
| 2016 |
Makvandi M, Tilahun ED, Lieberman BP, Xu K, Zeng C, Hou C, Mach RH. Abstract B42: The sigma-2 receptor as a target for therapeutic drug delivery in triple negative breast cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Fbcr15-B42 |
0.342 |
|
| 2015 |
Zhou D, Chu W, Peng X, McConathy J, Mach RH, Katzenellenbogen JA. Facile purification and click labeling with 2-[(18)F]fluoroethyl azide using solid phase extraction cartridges. Tetrahedron Letters. 56: 952-954. PMID 26989269 DOI: 10.1016/J.Tetlet.2014.10.126 |
0.448 |
|
| 2015 |
Solingapuram Sai KK, Gage D, Nader M, Mach RH, Mintz A. Improved Automated Radiosynthesis of [(11)C]PBR28. Scientia Pharmaceutica. 83: 413-27. PMID 26839827 DOI: 10.3797/Scipharm.1505-06 |
0.309 |
|
| 2015 |
Makvandi M, Tilahun ED, Lieberman BP, Anderson RC, Zeng C, Xu K, Hou C, McDonald ES, Pryma DA, Mach RH. The sigma-2 receptor as a therapeutic target for drug delivery in triple negative breast cancer. Biochemical and Biophysical Research Communications. PMID 26453012 DOI: 10.1016/J.Bbrc.2015.09.157 |
0.303 |
|
| 2015 |
Zeng C, Garg N, Mach RH. The PGRMC1 Protein Level Correlates with the Binding Activity of a Sigma-2 Fluorescent Probe (SW120) in Rat Brain Cells. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. PMID 26335282 DOI: 10.1007/S11307-015-0891-Z |
0.333 |
|
| 2015 |
Luedtke RR, Rangel-Barajas C, Malik M, Reichert DE, Mach RH. Bitropic D3 Dopamine Receptor Selective Compounds s Potential Antipsychotics. Current Pharmaceutical Design. 21: 3700-24. PMID 26205291 DOI: 10.2174/1381612821666150724100830 |
0.364 |
|
| 2015 |
Chu W, Zhou D, Gaba V, Liu J, Li S, Peng X, Xu J, Dhavale D, Bagchi DP, d'Avignon A, Shakerdge NB, Bacskai BJ, Tu Z, Kotzbauer PT, Mach RH. Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils. Journal of Medicinal Chemistry. 58: 6002-17. PMID 26177091 DOI: 10.1021/Acs.Jmedchem.5B00571 |
0.433 |
|
| 2015 |
Sahlholm K, Liao F, Holtzman DM, Xu J, Mach RH. Sigma-2 receptor binding is decreased in female, but not male, APP/PS1 mice. Biochemical and Biophysical Research Communications. 460: 439-45. PMID 25796326 DOI: 10.1016/J.Bbrc.2015.03.052 |
0.322 |
|
| 2015 |
Wu ZW, Song SY, Li L, Lu HL, Lieberman B, Huang YS, Mach RH. Synthesis and evaluation of tetrahydroindazole derivatives as sigma-2 receptor ligands. Bioorganic & Medicinal Chemistry. 23: 1463-71. PMID 25752422 DOI: 10.1016/J.Bmc.2015.02.012 |
0.406 |
|
| 2015 |
Rangel-Barajas C, Malik M, Mach RH, Luedtke RR. Pharmacological modulation of abnormal involuntary DOI-induced head twitch response movements in male DBA/2J mice: II. Effects of D3 dopamine receptor selective compounds. Neuropharmacology. 93: 179-90. PMID 25698528 DOI: 10.1016/J.Neuropharm.2014.10.030 |
0.378 |
|
| 2015 |
Peng X, Wang Q, Mishra Y, Xu J, Reichert DE, Malik M, Taylor M, Luedtke RR, Mach RH. Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands. Bioorganic & Medicinal Chemistry Letters. 25: 519-23. PMID 25556097 DOI: 10.1016/J.Bmcl.2014.12.023 |
0.528 |
|
| 2015 |
Chen DL, Engle JT, Griffin EA, Miller JP, Chu W, Zhou D, Mach RH. Imaging caspase-3 activation as a marker of apoptosis-targeted treatment response in cancer. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 17: 384-93. PMID 25344147 DOI: 10.1007/S11307-014-0802-8 |
0.319 |
|
| 2015 |
McDonald ES, Zeng C, Mankoff DA, Kossenkov A, Mach RH. Abstract 3791: PGRMC1 expression is significantly up-regulated in triple negative breast cancerin vivowith associated activation of cyclin D1 target genes: Analysis of 1019 invasive breast cancers in the TCGA database Cancer Research. 75: 3791-3791. DOI: 10.1158/1538-7445.Am2015-3791 |
0.311 |
|
| 2015 |
Zeng C, Mankoff J, Mach RH. Abstract 3481: Sigma-2 ligands sensitize triple negative breast cancer cells to PARP inhibitor treatment Cancer Research. 75: 3481-3481. DOI: 10.1158/1538-7445.Am2015-3481 |
0.358 |
|
| 2015 |
Makvandi M, Lieberman BP, Xu K, Anderson R, Zeng C, Mankoff DA, Pryma DA, Greenberg RA, Mach RH. Abstract C15: Predicting response to PARP inhibitors through quantitative measurements of PARP activity in live BRCA1 mutated cells with a radio-iodinated PARP inhibitor Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C15 |
0.305 |
|
| 2015 |
Xie F, Kniess T, Neuber C, Deuther-Conrad W, Mamat C, Lieberman BP, Liu B, Mach RH, Brust P, Steinbach J, Pietzsch J, Jia H. Novel indole-based sigma-2 receptor ligands: synthesis, structure-affinity relationship and antiproliferative activity Medchemcomm. 6: 1093-1103. DOI: 10.1039/C5Md00079C |
0.393 |
|
| 2015 |
Chu W, Zhou D, Gaba V, Liu J, Li S, Peng X, Xu J, Dhavale D, Bagchi DP, D'Avignon A, Shakerdge NB, Bacskai BJ, Tu Z, Kotzbauer PT, Mach RH. Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils Journal of Medicinal Chemistry. 58: 6002-6017. DOI: 10.1021/acs.jmedchem.5b00571 |
0.347 |
|
| 2015 |
Zhou D, Chu W, Peng X, McConathy J, Mach RH, Katzenellenbogen JA. Facile purification and click labeling with 2-[18F]fluoroethyl azide using solid phase extraction cartridges Tetrahedron Letters. 56: 952-954. DOI: 10.1016/j.tetlet.2014.10.126 |
0.336 |
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| 2014 |
Zhang X, Jin H, Padakanti PK, Li J, Yang H, Fan J, Mach RH, Kotzbauer P, Tu Z. Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein. Applied Sciences (Basel, Switzerland). 4: 66-78. PMID 25642331 DOI: 10.3390/App4010066 |
0.347 |
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| 2014 |
Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, ... Mach RH, et al. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. Plos One. 9: e111899. PMID 25390692 DOI: 10.1371/Journal.Pone.0111899 |
0.315 |
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| 2014 |
Rangel-Barajas C, Malik M, Taylor M, Neve KA, Mach RH, Luedtke RR. Characterization of [(3) H]LS-3-134, a novel arylamide phenylpiperazine D3 dopamine receptor selective radioligand. Journal of Neurochemistry. 131: 418-31. PMID 25041389 DOI: 10.1111/Jnc.12825 |
0.397 |
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| 2014 |
Sai KK, Fan J, Tu Z, Zerkel P, Mach RH, Kharasch ED. Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM). Applied Radiation and Isotopes : Including Data, Instrumentation and Methods For Use in Agriculture, Industry and Medicine. 91: 135-40. PMID 24935116 DOI: 10.1016/J.Apradiso.2014.05.019 |
0.304 |
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| 2014 |
Chu W, Chepetan A, Zhou D, Shoghi KI, Xu J, Dugan LL, Gropler RJ, Mintun MA, Mach RH. Development of a PET radiotracer for non-invasive imaging of the reactive oxygen species, superoxide, in vivo. Organic & Biomolecular Chemistry. 12: 4421-31. PMID 24847866 DOI: 10.1039/C3Ob42379D |
0.355 |
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| 2014 |
Bai S, Li S, Xu J, Peng X, Sai K, Chu W, Tu Z, Zeng C, Mach RH. Synthesis and structure-activity relationship studies of conformationally flexible tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands. Journal of Medicinal Chemistry. 57: 4239-51. PMID 24821398 DOI: 10.1021/Jm5001453 |
0.568 |
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| 2014 |
Hashim YM, Spitzer D, Vangveravong S, Hornick MC, Garg G, Hornick JR, Goedegebuure P, Mach RH, Hawkins WG. Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134. Molecular Oncology. 8: 956-67. PMID 24731702 DOI: 10.1016/J.Molonc.2014.03.005 |
0.347 |
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| 2014 |
Rangel-Barajas C, Malik M, Vangveravong S, Mach RH, Luedtke RR. Pharmacological modulation of abnormal involuntary DOI-induced head twitch response in male DBA/2J mice: I. Effects of D2/D3 and D2 dopamine receptor selective compounds. Neuropharmacology. 83: 18-27. PMID 24680675 DOI: 10.1016/J.Neuropharm.2014.03.003 |
0.372 |
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| 2014 |
Sun T, Wang Y, Wang Y, Xu J, Zhao X, Vangveravong S, Mach RH, Xia Y. Using SV119-gold nanocage conjugates to eradicate cancer stem cells through a combination of photothermal and chemo therapies. Advanced Healthcare Materials. 3: 1283-91. PMID 24677807 DOI: 10.1002/Adhm.201400026 |
0.301 |
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| 2014 |
Garg G, Vangveravong S, Zeng C, Collins L, Hornick M, Hashim Y, Piwnica-Worms D, Powell MA, Mutch DG, Mach RH, Hawkins WG, Spitzer D. Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer. Molecular Cancer. 13: 50. PMID 24602489 DOI: 10.1186/1476-4598-13-50 |
0.346 |
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| 2014 |
Zhou D, Chu W, Xu J, Jones LA, Peng X, Li S, Chen DL, Mach RH. Synthesis, [¹⁸F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography. Bioorganic & Medicinal Chemistry. 22: 1700-7. PMID 24503274 DOI: 10.1016/J.Bmc.2014.01.019 |
0.517 |
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| 2014 |
Zeng C, Rothfuss JM, Zhang J, Vangveravong S, Chu W, Li S, Tu Z, Xu J, Mach RH. Functional assays to define agonists and antagonists of the sigma-2 receptor. Analytical Biochemistry. 448: 68-74. PMID 24333652 DOI: 10.1016/J.Ab.2013.12.008 |
0.375 |
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| 2014 |
Garg G, Vangveravong S, Zeng C, Collins L, Hornick M, Hashim Y, Piwnica-Worms D, Powell MA, Mutch DG, Mach RH, Hawkins WG, Spitzer D. Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer Gynecologic Oncology. 133: 181. DOI: 10.1016/J.Ygyno.2014.03.478 |
0.373 |
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| 2013 |
Sun J, Kouranova E, Cui X, Mach RH, Xu J. Regulation of dopamine presynaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats. Neuroscience Letters. 557: 123-8. PMID 24157858 DOI: 10.1016/J.Neulet.2013.10.034 |
0.335 |
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| 2013 |
Tu Z, Li S, Li A, Taylor M, Ho D, Malik M, Luedtke RR, Mach RH. Synthesis and in vitro pharmacological evaluation of indolyl carboxylic amide analogues as D3 dopamine receptor selective ligands. Medchemcomm. 4: 1283-1289. PMID 24156012 DOI: 10.1039/C3Md00098B |
0.389 |
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| 2013 |
Zeng C, Vangveravong S, McDunn JE, Hawkins WG, Mach RH. Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer. British Journal of Cancer. 109: 2368-77. PMID 24104966 DOI: 10.1038/Bjc.2013.593 |
0.334 |
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| 2013 |
Shoghi KI, Xu J, Su Y, He J, Rowland D, Yan Y, Garbow JR, Tu Z, Jones LA, Higashikubo R, Wheeler KT, Lubet RA, Mach RH, You M. Quantitative receptor-based imaging of tumor proliferation with the sigma-2 ligand [(18)F]ISO-1. Plos One. 8: e74188. PMID 24073202 DOI: 10.1371/Journal.Pone.0074188 |
0.371 |
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| 2013 |
Huang R, Griffin SA, Taylor M, Vangveravong S, Mach RH, Dillon GH, Luedtke RR. The effect of SV 293, a D2 dopamine receptor-selective antagonist, on D2 receptor-mediated GIRK channel activation and adenylyl cyclase inhibition. Pharmacology. 92: 84-9. PMID 23942137 DOI: 10.1159/000351971 |
0.388 |
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| 2013 |
Mach RH, Zeng C, Hawkins WG. The σ2 receptor: a novel protein for the imaging and treatment of cancer. Journal of Medicinal Chemistry. 56: 7137-60. PMID 23734634 DOI: 10.1021/Jm301545C |
0.404 |
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| 2013 |
Sun J, Cairns NJ, Perlmutter JS, Mach RH, Xu J. Regulation of dopamine D₃ receptor in the striatal regions and substantia nigra in diffuse Lewy body disease. Neuroscience. 248: 112-26. PMID 23732230 DOI: 10.1016/J.Neuroscience.2013.05.048 |
0.319 |
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| 2013 |
Sai KK, Huang C, Yuan L, Zhou D, Piwnica-Worms D, Garbow JR, Engelbach JA, Mach RH, Rich KM, McConathy J. 18F-AFETP, 18F-FET, and 18F-FDG imaging of mouse DBT gliomas. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 54: 1120-6. PMID 23650628 DOI: 10.2967/Jnumed.112.113217 |
0.335 |
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| 2013 |
Li A, Mishra Y, Malik M, Wang Q, Li S, Taylor M, Reichert DE, Luedtke RR, Mach RH. Evaluation of N-phenyl homopiperazine analogs as potential dopamine D3 receptor selective ligands. Bioorganic & Medicinal Chemistry. 21: 2988-98. PMID 23618707 DOI: 10.1016/J.Bmc.2013.03.074 |
0.393 |
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| 2013 |
Sai KK, Jones LA, Mach RH. Development of (18)F-labeled PET probes for imaging cell proliferation. Current Topics in Medicinal Chemistry. 13: 892-908. PMID 23590172 DOI: 10.2174/1568026611313080003 |
0.351 |
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| 2013 |
Dehdashti F, Laforest R, Gao F, Shoghi KI, Aft RL, Nussenbaum B, Kreisel FH, Bartlett NL, Cashen A, Wagner-Johnson N, MacH RH. Assessment of cellular proliferation in tumors by PET using 18F-ISO-1 Journal of Nuclear Medicine. 54: 350-357. PMID 23359657 DOI: 10.2967/Jnumed.112.111948 |
0.341 |
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| 2013 |
Xu J, Vangveravong S, Li S, Fan J, Jones LA, Cui J, Wang R, Tu Z, Chu W, Perlmutter JS, Mach RH. Positron emission tomography imaging of dopamine D2 receptors using a highly selective radiolabeled D2 receptor partial agonist Neuroimage. 71: 168-174. PMID 23333701 DOI: 10.1016/J.Neuroimage.2013.01.007 |
0.393 |
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| 2013 |
Mach RH, Zeng C, Rothfuss JM, Zhang J, Vangveravong S, Chu W, Tu Z, Li S. Abstract 2131: Functional assays to define agonists and antagonists of sigma-2 receptors. Cancer Research. 73: 2131-2131. DOI: 10.1158/1538-7445.Am2013-2131 |
0.391 |
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| 2012 |
Luedtke RR, Mishra Y, Wang Q, Griffin SA, Bell-Horner C, Taylor M, Vangveravong S, Dillon GH, Huang RQ, Reichert DE, Mach RH. Comparison of the binding and functional properties of two structurally different D2 dopamine receptor subtype selective compounds. Acs Chemical Neuroscience. 3: 1050-62. PMID 23259040 DOI: 10.1021/Cn300142Q |
0.412 |
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| 2012 |
Sun J, Xu J, Cairns NJ, Perlmutter JS, Mach RH. Dopamine D1, D2, D3 receptors, vesicular monoamine transporter type-2 (VMAT2) and dopamine transporter (DAT) densities in aged human brain. Plos One. 7: e49483. PMID 23185343 DOI: 10.1371/Journal.Pone.0049483 |
0.347 |
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| 2012 |
Solingapuram Sai KK, Kil KE, Tu Z, Chu W, Finck BN, Rothfuss JM, Shoghi KI, Welch MJ, Gropler RJ, Mach RH. Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors. Bioorganic & Medicinal Chemistry Letters. 22: 6233-6. PMID 22939697 DOI: 10.1016/J.Bmcl.2012.08.010 |
0.354 |
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| 2012 |
Moussa IA, Banister SD, Manoli M, Doddareddy MR, Cui J, Mach RH, Kassiou M. Exploration of ring size in a series of cyclic vicinal diamines with σ₁ receptor affinity. Bioorganic & Medicinal Chemistry Letters. 22: 5493-7. PMID 22850210 DOI: 10.1016/J.Bmcl.2012.07.026 |
0.369 |
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| 2012 |
Hornick JR, Spitzer D, Goedegebuure P, Mach RH, Hawkins WG. Therapeutic targeting of pancreatic cancer utilizing sigma-2 ligands. Surgery. 152: S152-6. PMID 22763259 DOI: 10.1016/J.Surg.2012.05.014 |
0.325 |
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| 2012 |
Herrero P, Laforest R, Shoghi K, Zhou D, Ewald G, Pfeifer J, Duncavage E, Krupp K, Mach R, Gropler R. Feasibility and dosimetry studies for 18F-NOS as a potential PET radiopharmaceutical for inducible nitric oxide synthase in humans. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 53: 994-1001. PMID 22582045 DOI: 10.2967/Jnumed.111.088518 |
0.303 |
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| 2012 |
Hornick JR, Vangveravong S, Spitzer D, Abate C, Berardi F, Goedegebuure P, Mach RH, Hawkins WG. Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer. Journal of Experimental & Clinical Cancer Research : Cr. 31: 41. PMID 22551149 DOI: 10.1186/1756-9966-31-41 |
0.349 |
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| 2012 |
Luedtke RR, Perez E, Yang SH, Liu R, Vangveravong S, Tu Z, Mach RH, Simpkins JW. Neuroprotective effects of high affinity Σ1 receptor selective compounds. Brain Research. 1441: 17-26. PMID 22285434 DOI: 10.1016/J.Brainres.2011.12.047 |
0.402 |
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| 2012 |
Wang Y, Xu J, Xia X, Yang M, Vangveravong S, Chen J, Mach RH, Xia Y. SV119-gold nanocage conjugates: a new platform for targeting cancer cells via sigma-2 receptors. Nanoscale. 4: 421-4. PMID 22113350 DOI: 10.1039/C1Nr11469G |
0.33 |
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| 2012 |
Spitzer D, Simon PO, Kashiwagi H, Xu J, Zeng C, Vangveravong S, Zhou D, Chang K, McDunn JE, Hornick JR, Goedegebuure P, Hotchkiss RS, Mach RH, Hawkins WG. Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling. Cancer Research. 72: 201-9. PMID 22065721 DOI: 10.1158/0008-5472.Can-11-1354 |
0.379 |
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| 2012 |
Lee H, Chen DL, Rothfuss JM, Welch MJ, Gropler RJ, Mach RH. Synthesis and evaluation of 18F-labeled PPARγ antagonists. Nuclear Medicine and Biology. 39: 77-87. PMID 21907585 DOI: 10.1016/J.Nucmedbio.2011.07.002 |
0.441 |
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| 2012 |
Haller JL, Panyutin I, Chaudhry A, Zeng C, Mach RH, Frank JA. Sigma-2 receptor as potential indicator of stem cell differentiation. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 14: 325-35. PMID 21614680 DOI: 10.1007/S11307-011-0493-3 |
0.344 |
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| 2012 |
Zeng C, Vangveravong S, Rothfuss JM, Xu J, Mach RH. Abstract 5690: Validating sigma-2 receptor ligand as a novel tumor-targeted drug delivery agent for treating ovarian cancer Cancer Research. 72: 5690-5690. DOI: 10.1158/1538-7445.Am2012-5690 |
0.383 |
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| 2012 |
Xu J, Cai X, Yao J, Dirk S, Zeng C, Hawkins WG, Wang LV, Mach RH. Abstract 356: Photoacoustic imaging of pancreatic cancer proliferation via sigma-2 receptor/PGRMC1-eYFP Cancer Research. 72: 356-356. DOI: 10.1158/1538-7445.Am2012-356 |
0.404 |
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| 2011 |
Zeng C, Vangveravong S, Jones LA, Hyrc K, Chang KC, Xu J, Rothfuss JM, Goldberg MP, Hotchkiss RS, Mach RH. Characterization and evaluation of two novel fluorescent sigma-2 receptor ligands as proliferation probes. Molecular Imaging. 10: 420-33. PMID 22201533 DOI: 10.2310/7290.2011.00009 |
0.357 |
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| 2011 |
Banister SD, Yoo DT, Chua SW, Cui J, Mach RH, Kassiou M. N-Arylalkyl-2-azaadamantanes as cage-expanded polycarbocyclic sigma (σ) receptor ligands. Bioorganic & Medicinal Chemistry Letters. 21: 5289-92. PMID 21788137 DOI: 10.1016/J.Bmcl.2011.07.028 |
0.32 |
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| 2011 |
Xu J, Zeng C, Chu W, Pan F, Rothfuss JM, Zhang F, Tu Z, Zhou D, Zeng D, Vangveravong S, Johnston F, Spitzer D, Chang KC, Hotchkiss RS, Hawkins WG, ... ... Mach RH, et al. Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nature Communications. 2: 380. PMID 21730960 DOI: 10.1038/Ncomms1386 |
0.387 |
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| 2011 |
Tu Z, Li S, Xu J, Chu W, Jones LA, Luedtke RR, Mach RH. Effect of cyclosporin A on the uptake of D3-selective PET radiotracers in rat brain. Nuclear Medicine and Biology. 38: 725-39. PMID 21718948 DOI: 10.1016/J.Nucmedbio.2011.01.002 |
0.383 |
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| 2011 |
Lim MM, Xu J, Holtzman DM, Mach RH. Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum. Neuroreport. 22: 489-93. PMID 21642879 DOI: 10.1097/Wnr.0B013E32834846A0 |
0.31 |
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| 2011 |
Vangveravong S, Zhang Z, Taylor M, Bearden M, Xu J, Cui J, Wang W, Luedtke RR, Mach RH. Synthesis and characterization of selective dopamine D₂ receptor ligands using aripiprazole as the lead compound. Bioorganic & Medicinal Chemistry. 19: 3502-11. PMID 21536445 DOI: 10.1016/J.Bmc.2011.04.021 |
0.4 |
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| 2011 |
Tu Z, Li S, Cui J, Xu J, Taylor M, Ho D, Luedtke RR, Mach RH. Synthesis and pharmacological evaluation of fluorine-containing D₃ dopamine receptor ligands. Journal of Medicinal Chemistry. 54: 1555-64. PMID 21348515 DOI: 10.1021/Jm101323B |
0.4 |
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| 2011 |
Tu Z, Fan J, Li S, Jones LA, Cui J, Padakanti PK, Xu J, Zeng D, Shoghi KI, Perlmutter JS, MacH RH. Radiosynthesis and in vivo evaluation of [ 11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain Bioorganic and Medicinal Chemistry. 19: 1666-1673. PMID 21315609 DOI: 10.1016/J.Bmc.2011.01.032 |
0.32 |
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| 2011 |
Mach RH, Tu Z, Xu J, Li S, Jones LA, Taylor M, Luedtke RR, Derdeyn CP, Perlmutter JS, Mintun MA. Endogenous dopamine (DA) competes with the binding of a radiolabeled D3 receptor partial agonist in vivo: A positron emission tomography study Synapse. 65: 724-732. PMID 21132811 DOI: 10.1002/Syn.20891 |
0.419 |
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| 2011 |
Karimi M, Moerlein SM, Videen TO, Luedtke RR, Taylor M, Mach RH, Perlmutter JS. Decreased striatal dopamine receptor binding in primary focal dystonia: A D2 or D3 defect? Movement Disorders. 26: 100-106. PMID 20960437 DOI: 10.1002/Mds.23401 |
0.395 |
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| 2010 |
Mach RH, Schwarz SW. Challenges for Developing PET Tracers: Isotopes, Chemistry, and Regulatory Aspects. Pet Clinics. 5: 131-53. PMID 27157669 DOI: 10.1016/J.Cpet.2010.02.002 |
0.3 |
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| 2010 |
Hornick JR, Xu J, Vangveravong S, Tu Z, Mitchem JB, Spitzer D, Goedegebuure P, Mach RH, Hawkins WG. The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine. Molecular Cancer. 9: 298. PMID 21092190 DOI: 10.1186/1476-4598-9-298 |
0.36 |
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| 2010 |
McConathy J, Zhou D, Shockley SE, Jones LA, Griffin EA, Lee H, Adams SJ, Mach RH. Click synthesis and biologic evaluation of (R)- and (S)-2-amino-3-[1-(2-[18F]fluoroethyl)-1H-[1,2,3]triazol-4-yl]propanoic acid for brain tumor imaging with positron emission tomography. Molecular Imaging. 9: 329-42. PMID 21084029 DOI: 10.2310/7290.2010.00025 |
0.34 |
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| 2010 |
Wang Q, Mach RH, Luedtke RR, Reichert DE. Subtype selectivity of dopamine receptor ligands: insights from structure and ligand-based methods. Journal of Chemical Information and Modeling. 50: 1970-85. PMID 20936866 DOI: 10.1021/Ci1002747 |
0.392 |
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| 2010 |
Tu Z, Xu J, Jones LA, Li S, Zeng D, Kung MP, Kung HF, Mach RH. Radiosynthesis and biological evaluation of a promising sigma(2)-receptor ligand radiolabeled with fluorine-18 or iodine-125 as a PET/SPECT probe for imaging breast cancer. Applied Radiation and Isotopes : Including Data, Instrumentation and Methods For Use in Agriculture, Industry and Medicine. 68: 2268-73. PMID 20594864 DOI: 10.1016/J.Apradiso.2010.06.004 |
0.422 |
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| 2010 |
Vangveravong S, Taylor M, Xu J, Cui J, Calvin W, Babic S, Luedtke RR, Mach RH. Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626. Bioorganic & Medicinal Chemistry. 18: 5291-300. PMID 20542439 DOI: 10.1016/J.Bmc.2010.05.052 |
0.38 |
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| 2010 |
Tu Z, Xu J, Jones LA, Li S, Mach RH. Carbon-11 labeled papaverine as a PET tracer for imaging PDE10A: radiosynthesis, in vitro and in vivo evaluation. Nuclear Medicine and Biology. 37: 509-16. PMID 20447563 DOI: 10.1016/J.Nucmedbio.2009.12.012 |
0.342 |
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| 2010 |
Tu Z, Mach RH. C-11 radiochemistry in cancer imaging applications Current Topics in Medicinal Chemistry. 10: 1060-1095. PMID 20388115 DOI: 10.2174/156802610791384261 |
0.317 |
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| 2010 |
Efange SM, Khare AB, von Hohenberg K, Mach RH, Parsons SM, Tu Z. Synthesis and in vitro biological evaluation of carbonyl group-containing inhibitors of vesicular acetylcholine transporter. Journal of Medicinal Chemistry. 53: 2825-35. PMID 20218624 DOI: 10.1021/Jm9017916 |
0.33 |
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| 2010 |
Xu J, Hassanzadeh B, Chu W, Tu Z, Jones LA, Luedtke RR, Perlmutter JS, Mintun MA, Mach RH. [3H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)- butyl)benzamide: A selective radioligand for dopamine D3 receptors. II. Quantitative analysis of dopamine D3 and D2 receptor density ratio in the caudate-putamen Synapse. 64: 449-459. PMID 20175227 DOI: 10.1002/Syn.20748 |
0.374 |
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| 2010 |
Xu J, Zeng C, Chu W, Pan F, Mach RH. Abstract 1054: Identification of progesterone receptor membrane component-1 as the putative sigma-2 receptor Cancer Research. 70: 1054-1054. DOI: 10.1158/1538-7445.Am10-1054 |
0.393 |
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| 2009 |
Mach RH, Dehdashti F, Wheeler KT. PET Radiotracers for Imaging the Proliferative Status of Solid Tumors. Pet Clinics. 4: 1-15. PMID 20046891 DOI: 10.1016/J.Cpet.2009.04.012 |
0.352 |
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| 2009 |
Mach RH, Wheeler KT. Development of molecular probes for imaging sigma-2 receptors in vitro and in vivo Central Nervous System Agents in Medicinal Chemistry. 9: 230-245. PMID 20021357 DOI: 10.2174/1871524910909030230 |
0.416 |
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| 2009 |
Chen DL, Zhou D, Chu W, Herrbrich PE, Jones LA, Rothfuss JM, Engle JT, Geraci M, Welch MJ, Mach RH. Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomography. Nuclear Medicine and Biology. 36: 651-8. PMID 19647171 DOI: 10.1016/J.Nucmedbio.2009.03.008 |
0.317 |
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| 2009 |
Wang Q, Mach RH, Reichert DE. Docking and 3D-QSAR studies on isatin sulfonamide analogues as caspase-3 inhibitors. Journal of Chemical Information and Modeling. 49: 1963-73. PMID 19610597 DOI: 10.1021/Ci900144X |
0.319 |
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| 2009 |
Weber M, Chang WL, Durbin JP, Park PE, Luedtke RR, Mach RH, Swerdlow NR. Using prepulse inhibition to detect functional D3 receptor antagonism: effects of WC10 and WC44. Pharmacology, Biochemistry, and Behavior. 93: 141-7. PMID 19426754 DOI: 10.1016/J.Pbb.2009.04.022 |
0.327 |
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| 2009 |
Xu J, Chu W, Tu Z, Jones LA, Luedtke RR, Perlmutter JS, Mintun MA, Mach RH. [3H]4-(dimethylamino)-N-[4-(4-(2-methoxyphenyl)piperazin-1-yl) butyl]benzamide, a selective radioligand for dopamine D3 receptors. I. In vitro characterization Synapse. 63: 717-728. PMID 19425052 DOI: 10.1002/Syn.20652 |
0.381 |
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| 2009 |
Kumar R, Riddle LR, Griffin SA, Chu W, Vangveravong S, Neisewander J, Mach RH, Luedtke RR. Evaluation of D2 and D3 dopamine receptor selective compounds on l-dopa-dependent abnormal involuntary movements in rats Neuropharmacology. 56: 956-969. PMID 19371586 DOI: 10.1016/J.Neuropharm.2009.01.019 |
0.376 |
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| 2009 |
Kashiwagi H, McDunn JE, Simon PO, Goedegebuure PS, Vangveravong S, Chang K, Hotchkiss RS, Mach RH, Hawkins WG. Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma. Journal of Translational Medicine. 7: 24. PMID 19323815 DOI: 10.1186/1479-5876-7-24 |
0.356 |
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| 2009 |
Zhou D, Lee H, Rothfuss JM, Chen DL, Ponde DE, Welch MJ, Mach RH. Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase. Journal of Medicinal Chemistry. 52: 2443-53. PMID 19323559 DOI: 10.1021/Jm801556H |
0.318 |
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| 2009 |
Zhou D, Chu W, Chen DL, Wang Q, Reichert DE, Rothfuss J, D'Avignon A, Welch MJ, Mach RH. [18F]- and [11C]-labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [11C]WC-98. Organic & Biomolecular Chemistry. 7: 1337-48. PMID 19300818 DOI: 10.1039/B819024K |
0.347 |
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| 2009 |
Tu Z, Efange SM, Xu J, Li S, Jones LA, Parsons SM, Mach RH. Synthesis and in vitro and in vivo evaluation of 18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter. Journal of Medicinal Chemistry. 52: 1358-69. PMID 19203271 DOI: 10.1021/Jm8012344 |
0.346 |
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| 2009 |
Chu W, Xu J, Zhou D, Zhang F, Jones LA, Wheeler KT, Mach RH. New N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl phenylcarbamate analogs as sigma2 receptor ligands: synthesis, in vitro characterization, and evaluation as PET imaging and chemosensitization agents. Bioorganic & Medicinal Chemistry. 17: 1222-31. PMID 19119012 DOI: 10.1016/J.Bmc.2008.12.025 |
0.432 |
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| 2009 |
Shoghi K, He J, Su Y, Yan Y, Rowland D, Garbow J, Mach R, Lubet R, You M. Multi-modality imaging of N-methyl-N-nitrosourea-induced mammary tumors by MRI and small animal PET. Cancer Research. 69: 6008. DOI: 10.1158/0008-5472.Sabcs-6008 |
0.342 |
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| 2007 |
Zeng C, Vangveravong S, Xu J, Chang KC, Hotchkiss RS, Wheeler KT, Shen D, Zhuang ZP, Kung HF, Mach RH. Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy. Cancer Research. 67: 6708-16. PMID 17638881 DOI: 10.1158/0008-5472.Can-06-3803 |
0.35 |
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| 2007 |
Kashiwagi H, McDunn JE, Simon PO, Goedegebuure PS, Xu J, Jones L, Chang K, Johnston F, Trinkaus K, Hotchkiss RS, Mach RH, Hawkins WG. Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy. Molecular Cancer. 6: 48. PMID 17631687 DOI: 10.1186/1476-4598-6-48 |
0.361 |
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| 2007 |
Tu Z, Xu J, Jones LA, Li S, Dumstorff C, Vangveravong S, Chen DL, Wheeler KT, Welch MJ, Mach RH. Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomography. Journal of Medicinal Chemistry. 50: 3194-204. PMID 17579383 DOI: 10.1021/Jm0614883 |
0.415 |
|
| 2007 |
Lee BC, Lee KC, Lee H, Mach RH, Katzenellenbogen JA. Strategies for the labeling of halogen-substituted peroxisome proliferator-activated receptor gamma ligands: potential positron emission tomography and single photon emission computed tomography imaging agents. Bioconjugate Chemistry. 18: 514-23. PMID 17315977 DOI: 10.1021/Bc060191G |
0.391 |
|
| 2007 |
Lee BC, Lee KC, Lee H, Mach RH, Katzenellenbogen JA. Synthesis and binding affinity of a fluorine-substituted peroxisome proliferator-activated gamma (PPARgamma) ligand as a potential positron emission tomography (PET) imaging agent. Bioconjugate Chemistry. 18: 507-13. PMID 17309226 DOI: 10.1021/Bc060190O |
0.409 |
|
| 2007 |
Jost SC, Wanebo JE, Song SK, Chicoine MR, Rich KM, Woolsey TA, Lewis JS, Mach RH, Xu J, Garbow JR. In vivo imaging in a murine model of glioblastoma. Neurosurgery. 60: 360-70; discussion 3. PMID 17290188 DOI: 10.1227/01.Neu.0000249264.80579.37 |
0.334 |
|
| 2007 |
Mach RH, Wheeler KT. Imaging the proliferative status of tumors with PET Journal of Labelled Compounds and Radiopharmaceuticals. 50: 366-369. DOI: 10.1002/Jlcr.1269 |
0.344 |
|
| 2006 |
Lee H, Finck BN, Jones LA, Welch MJ, Mach RH. Synthesis and evaluation of a bromine-76-labeled PPARgamma antagonist 2-bromo-5-nitro-N-phenylbenzamide. Nuclear Medicine and Biology. 33: 847-54. PMID 17045164 DOI: 10.1016/J.Nucmedbio.2006.08.003 |
0.4 |
|
| 2006 |
Zhou D, Chu W, Rothfuss J, Zeng C, Xu J, Jones L, Welch MJ, Mach RH. Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis. Bioorganic & Medicinal Chemistry Letters. 16: 5041-6. PMID 16891117 DOI: 10.1016/J.Bmcl.2006.07.045 |
0.323 |
|
| 2006 |
Vangveravong S, Xu J, Zeng C, Mach RH. Synthesis of N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl carbamate analogs as σ2 receptor ligands Bioorganic and Medicinal Chemistry. 14: 6988-6997. PMID 16837201 DOI: 10.1016/J.Bmc.2006.06.028 |
0.351 |
|
| 2006 |
Nader MA, Morgan D, Gage HD, Nader SH, Calhoun TL, Buchheimer N, Ehrenkaufer R, Mach RH. PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys. Nature Neuroscience. 9: 1050-6. PMID 16829955 DOI: 10.1038/Nn1737 |
0.326 |
|
| 2006 |
Hou C, Tu Z, Mach R, Kung HF, Kung MP. Characterization of a novel iodinated sigma-2 receptor ligand as a cell proliferation marker. Nuclear Medicine and Biology. 33: 203-9. PMID 16546674 DOI: 10.1016/J.Nucmedbio.2005.10.001 |
0.418 |
|
| 2006 |
Vangveravong S, McElveen E, Taylor M, Xu J, Tu Z, Luedtke RR, Mach RH. Synthesis and characterization of selective dopamine D2 receptor antagonists. Bioorganic & Medicinal Chemistry. 14: 815-25. PMID 16288878 DOI: 10.1016/J.Bmc.2005.09.008 |
0.395 |
|
| 2005 |
Mach RH, Gage HD, Buchheimer N, Huang Y, Kuhner R, Wu L, Morton TE, Ehrenkaufer RL. N-[18F]4'-fluorobenzylpiperidin-4yl-(2-fluorophenyl) acetamide ([18F]FBFPA): a potential fluorine-18 labeled PET radiotracer for imaging sigma-1 receptors in the CNS. Synapse (New York, N.Y.). 58: 267-74. PMID 16206186 DOI: 10.1002/Syn.20207 |
0.404 |
|
| 2005 |
Tu Z, Chu W, Zhang J, Dence CS, Welch MJ, Mach RH. Synthesis and in vivo evaluation of [11C]PJ34, a potential radiotracer for imaging the role of PARP-1 in necrosis Nuclear Medicine and Biology. 32: 437-443. PMID 15982573 DOI: 10.1016/J.Nucmedbio.2005.03.001 |
0.335 |
|
| 2005 |
Tu Z, Dence CS, Ponde DE, Jones L, Wheeler KT, Welch MJ, Mach RH. Carbon-11 labeled sigma2 receptor ligands for imaging breast cancer. Nuclear Medicine and Biology. 32: 423-30. PMID 15982571 DOI: 10.1016/J.Nucmedbio.2005.03.008 |
0.383 |
|
| 2005 |
Chu W, Tu Z, McElveen E, Xu J, Taylor M, Luedtke RR, Mach RH. Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands. Bioorganic & Medicinal Chemistry. 13: 77-87. PMID 15582454 DOI: 10.1016/J.Bmc.2004.09.054 |
0.351 |
|
| 2004 |
Dence CS, Herrero P, Schwarz SW, Mach RH, Gropler RJ, Welch MJ. Imaging myocardium enzymatic pathways with carbon-11 radiotracers Methods in Enzymology. 385: 286-315. PMID 15130745 DOI: 10.1016/S0076-6879(04)85016-X |
0.307 |
|
| 2004 |
Clark PB, Gage HD, Brown-Proctor C, Buchheimer N, Calles-Escandon J, Mach RH, Morton KA. Neurofunctional imaging of the pancreas utilizing the cholinergic PET radioligand [18F]4-fluorobenzyltrozamicol European Journal of Nuclear Medicine and Molecular Imaging. 31: 258-260. PMID 15129709 DOI: 10.1007/S00259-003-1350-7 |
0.313 |
|
| 2004 |
Mach RH, Huang Y, Freeman RA, Wu L, Vangveravong S, Luedtke RR. Conformationally-flexible benzamide analogues as dopamine D3 and sigma 2 receptor ligands. Bioorganic & Medicinal Chemistry Letters. 14: 195-202. PMID 14684327 DOI: 10.1016/J.Bmcl.2003.09.083 |
0.428 |
|
| 2003 |
Leudtke RR, Mach RH. Progress in developing D3 dopamine receptor ligands as potential therapeutic agents for neurological and neuropsychiatric disorders Current Pharmaceutical Design. 9: 643-671. PMID 12570797 DOI: 10.2174/1381612033391199 |
0.357 |
|
| 2003 |
Mach RH, Huang Y, Freeman RA, Wu L, Blair S, Luedtke RR. Synthesis of 2-(5-bromo-2,3-dimethoxyphenyl)-5-(aminomethyl)-1H-pyrrole analogues and their binding affinities for dopamine D2, D3, and D4 receptors. Bioorganic & Medicinal Chemistry. 11: 225-33. PMID 12470717 DOI: 10.1016/S0968-0896(02)00341-3 |
0.386 |
|
| 2002 |
Morgan D, Grant KA, Gage HD, Mach RH, Kaplan JR, Prioleau O, Nader SH, Buchheimer N, Ehrenkaufer RL, Nader MA. Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nature Neuroscience. 5: 169-74. PMID 11802171 DOI: 10.1038/Nn798 |
0.311 |
|
| 2001 |
Huang Y, Hammond PS, Wu L, Mach RH. Synthesis and structure-activity relationships of N-(1-benzylpiperidin-4-yl)arylacetamide analogues as potent σ1receptor ligands Journal of Medicinal Chemistry. 44: 4404-4415. PMID 11728186 DOI: 10.1021/Jm010384J |
0.395 |
|
| 2001 |
Huang Y, Luedtke RR, Freeman RA, Wu L, Mach RH. Synthesis of 2-(2,3-dimethoxyphenyl)-4-(aminomethyl)imidazole analogues and their binding affinities for dopamine D2 and D3 receptors Bioorganic and Medicinal Chemistry. 9: 3113-3122. PMID 11711286 DOI: 10.1016/S0968-0896(01)00175-4 |
0.402 |
|
| 2001 |
Choi SR, Yang B, Plössl K, Chumpradit S, Wey SP, Acton PD, Wheeler K, Mach RH, Kung HF. Development of a Tc-99m labeled sigma-2 receptor-specific ligand as a potential breast tumor imaging agent Nuclear Medicine and Biology. 28: 657-666. PMID 11518647 DOI: 10.1016/S0969-8051(01)00234-7 |
0.384 |
|
| 2001 |
Mach RH, Huang Y, Buchheimer N, Kuhner R, Wu L, Morton TE, Wang LM, Ehrenkaufer RL, Wallen CA, Wheeler KT. [18F]N-4′-Fluorobenzyl-4-(3-bromophenyl) acetamide for imaging the sigma receptor status of tumors: Comparison with [18F]FDG and [125I]IUDR Nuclear Medicine and Biology. 28: 451-458. PMID 11395319 DOI: 10.1016/S0969-8051(01)00201-3 |
0.402 |
|
| 2001 |
Huang Y, Luedtke RR, Freeman RA, Wu L, Mach RH. Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands Journal of Medicinal Chemistry. 44: 1815-1826. PMID 11356115 DOI: 10.1021/Jm0100077 |
0.399 |
|
| 2001 |
Mach RH, Wheeler KT, Blair S, Yang B, Day CS, Blair JB, Choi SR, Kung HF. Preparation of a technetium-99m SPECT agent for imaging the sigma-2 receptor status of solid tumors Journal of Labelled Compounds and Radiopharmaceuticals. 44: 899-908. DOI: 10.1002/Jlcr.516 |
0.404 |
|
| 2000 |
Efange SMN, Von Hohenberg K, Khare AB, Tu Z, Mach RH, Parsons SM. Synthesis and biological characterization of stable and radioiodinated (±)-trans-2-hydroxy-3-P{4-(3-iodophenyl)piperidyl}-1,2,3,4-tetrahyd ronaphthalene (3′-IBVM) Nuclear Medicine and Biology. 27: 749-755. PMID 11150707 DOI: 10.1016/S0969-8051(00)00157-8 |
0.334 |
|
| 2000 |
Luedtke RR, Freeman RA, Boundy VA, Martin MW, Huang Y, Mach RH. Characterization of 125I-IABN, a novel azabicyclononane benzamide selective for D2-like dopamine receptors Synapse. 38: 438-449. PMID 11044891 DOI: 10.1002/1098-2396(20001215)38:4<438::Aid-Syn9>3.0.Co;2-5 |
0.397 |
|
| 2000 |
Mach RH, Nader MA, Ehrenkaufer RL, Gage HD, Childers SR, Hodges LM, Hodges MM, Davies HM. Fluorine-18-labeled tropane analogs for PET imaging studies of the dopamine transporter. Synapse (New York, N.Y.). 37: 109-17. PMID 10881032 DOI: 10.1002/1098-2396(200008)37:2<109::Aid-Syn5>3.0.Co;2-3 |
0.358 |
|
| 2000 |
Wheeler KT, Wang LM, Wallen CA, Childers SR, Cline JM, Keng PC, Mach RH. Sigma-2 receptors as a biomarker of proliferation in solid tumours British Journal of Cancer. 82: 1223-1232. PMID 10735510 DOI: 10.1054/Bjoc.1999.1067 |
0.329 |
|
| 1999 |
Nader MA, Green KL, Luedtke RR, Mach RH. The effects of benzamide analogues on cocaine self-administration in rhesus monkeys. Psychopharmacology. 147: 143-52. PMID 10591881 DOI: 10.1007/S002130051154 |
0.319 |
|
| 1999 |
Khare AB, Langason RB, Parsons SM, Mach RH, Efange SMN. N-(3-iodophenyl)trozamicol (IPHT) and related inhibitors of vesicular acetylcholine transport: Synthesis and preliminary biological characterization Nuclear Medicine and Biology. 26: 609-617. PMID 10587098 DOI: 10.1016/S0969-8051(99)00013-X |
0.316 |
|
| 1999 |
Al-Nabulsi I, Mach RH, Wang LM, Wallen CA, Keng PC, Sten K, Childers SR, Wheeler KT. Effect of ploidy, recruitment, environmental factors, and tamoxifen treatment on the expression of sigma-2 receptors in proliferating and quiescent tumour cells British Journal of Cancer. 81: 925-933. PMID 10576647 DOI: 10.1038/Sj.Bjc.6690789 |
0.334 |
|
| 1999 |
Nader MA, Grant KA, Gage HD, Ehrenkaufer RL, Kaplan JR, Mach RH. PET imaging of dopamine D2 receptors with [18F]fluoroclebopride in monkeys: effects of isoflurane- and ketamine-induced anesthesia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 21: 589-96. PMID 10481842 DOI: 10.1016/S0893-133X(98)00101-8 |
0.4 |
|
| 1999 |
Efange SMN, Khare AB, Mach RH, Parsons SM. Hydroxylated decahydroquinolines as ligands for the vesicular acetylcholine transporter: Synthesis and biological evaluation Journal of Medicinal Chemistry. 42: 2862-2869. PMID 10425095 DOI: 10.1021/Jm980560X |
0.343 |
|
| 1999 |
Efange SM, Nader MA, Ehrenkaufer RL, Khare AB, Smith CR, Morton TE, Mach RH. (+)-p-([18F]fluorobenzyl)spirotrozamicol [(+)-[18F]spiro-FBT]: synthesis and biological evaluation of a high-affinity ligand for the vesicular acetylcholine transporter (VAChT). Nuclear Medicine and Biology. 26: 189-92. PMID 10100218 DOI: 10.1016/S0969-8051(98)00090-0 |
0.341 |
|
| 1999 |
Mach RH, Wu L, West T, Whirrett BR, Childers SR. The analgesic tropane analogue (±)-SM 21 has a high affinity for σ2 receptors Life Sciences. 64: PL131-PL137. PMID 10096443 DOI: 10.1016/S0024-3205(99)00014-4 |
0.37 |
|
| 1998 |
Huang Y, Hammond PS, Whirrett BR, Kuhner RJ, Wu L, Childers SR, Mach RH. Synthesis and quantitative structure-activity relationships of N-(1- benzylpiperidin-4-yl)phenylacetamides and related analogues as potent and selective σ1 receptor ligands Journal of Medicinal Chemistry. 41: 2361-2370. PMID 9632369 DOI: 10.1021/Jm980032L |
0.417 |
|
| 1998 |
Grant KA, Shively CA, Nader MA, Ehrenkaufer RL, Line SW, Morton TE, Gage HD, Mach RH. Effect of social status on striatal dopamine D2 receptor binding characteristics in cynomolgus monkeys assessed with positron emission tomography. Synapse (New York, N.Y.). 29: 80-3. PMID 9552177 DOI: 10.1002/(Sici)1098-2396(199805)29:1<80::Aid-Syn7>3.0.Co;2-7 |
0.357 |
|
| 1997 |
Efange SMN, Kamath AP, Khare AB, Kung MP, Mach RH, Parsons SM. N-hydroxyalkyl derivatives of 3β-phenyltropane and 1-methylspiro[1H- indoline-3,4'-piperidine]: Vesamicol analogues with affinity for monoamine transporters Journal of Medicinal Chemistry. 40: 3905-3914. PMID 9397171 DOI: 10.1021/Jm970326R |
0.308 |
|
| 1997 |
Mach RH, Nader MA, Ehrenkaufer RL, Line SW, Smith CR, Gage HD, Morton TE. Use of positron emission tomography to study the dynamics of psychostimulant-induced dopamine release. Pharmacology, Biochemistry, and Behavior. 57: 477-86. PMID 9218272 DOI: 10.1016/S0091-3057(96)00449-2 |
0.355 |
|
| 1997 |
Mach RH, Voytko ML, Ehrenkaufer RL, Nader MA, Tobin JR, Efange SM, Parsons SM, Gage HD, Smith CR, Morton TE. Imaging of cholinergic terminals using the radiotracer [18F](+)-4-fluorobenzyltrozamicol: in vitro binding studies and positron emission tomography studies in nonhuman primates. Synapse (New York, N.Y.). 25: 368-80. PMID 9097396 DOI: 10.1002/(Sici)1098-2396(199704)25:4<368::Aid-Syn8>3.0.Co;2-8 |
0.403 |
|
| 1996 |
Mach RH, Nader MA, Ehrenkaufer RL, Line SW, Smith CR, Luedtke RR, Kung MP, Kung HF, Lyons D, Morton TE. Comparison of two fluorine-18 labeled benzamide derivatives that bind reversibly to dopamine D2 receptors: in vitro binding studies and positron emission tomography. Synapse (New York, N.Y.). 24: 322-33. PMID 10638823 DOI: 10.1002/(Sici)1098-2396(199612)24:4<322::Aid-Syn2>3.0.Co;2-F |
0.438 |
|
| 1995 |
Mach RH, Ehrenkaufer RL, Greenberg JH, Shao L, Morton TE, Evora PH, Nowak PA, Luedtke RR, Cohen D, Reivich M. PET imaging studies of dopamine D2 receptors: comparison of [18F]N-methylspiperone and the benzamide analogues [18F]MABN and [18F]MBP in baboon brain. Synapse (New York, N.Y.). 19: 177-87. PMID 7784958 DOI: 10.1002/Syn.890190305 |
0.355 |
|
| 1995 |
Efange SMN, Mach RH, Smith CR, Khare AB, Foulon C, Akella SK, Childers SR, Parsons SM. Vesamicol analogues as sigma ligands. Molecular determinants of selectivity at the vesamicol receptor Biochemical Pharmacology. 49: 791-797. PMID 7702637 DOI: 10.1016/0006-2952(94)00541-S |
0.32 |
|
| 1995 |
Mach RH, Smith CR, Childers SR. Ibogaine possesses a selective affinity for σ2 receptors Life Sciences. 57: PL57-PL62. PMID 7603301 DOI: 10.1016/0024-3205(95)00301-L |
0.389 |
|
| 1995 |
Elder ST, Mach RH, Nowak PA, Moroney DA, Rao AV, Ehrenkaufer RLE. Esters of 6‐(4′‐fluorobenzylamino)‐β‐ carboline‐3‐carboxylic acid as potential benzodiazepine imaging agents for P.E.T Journal of Labelled Compounds and Radiopharmaceuticals. 36: 205-211. DOI: 10.1002/Jlcr.2580360302 |
0.313 |
|
| 1994 |
Efange SMN, Mach RH, Khare A, Michelson RH, Nowak PA, Evora PH. p-[18F]fluorobenzyltrozamicol ([18F]FBT): Molecular decomposition-reconstitution approach to vesamicol receptor radioligands for positron emission tomography Applied Radiation and Isotopes. 45: 465-472. PMID 8186771 DOI: 10.1016/0969-8043(94)90113-9 |
0.349 |
|
| 1993 |
Mach RH, Nowak PA, Moroney DA, Morton TE, Jackson JR, Ehrenkaufer RL. Synthesis and in vivo evaluation of [18F]-N-(p-nitrobenzyl)spiperone ([18F]PNBS) in rats. Nuclear Medicine and Biology. 20: 269-78. PMID 8485486 DOI: 10.1016/0969-8051(93)90048-Y |
0.351 |
|
| 1993 |
Mach RH, Elder ST, Morton TE, Nowak PA, Evora PH, Scripko JG, Luedtke RR, Unsworth CD, Filtz T, Rao AV, Molinoff PB, Ehrenkaufer RLE. The use of [18F]4-fluorobenzyl iodide (FBI) in PET radiotracer synthesis: Model alkylation studies and its application in the design of dopamine D1 and D2 receptor-based imaging agents Nuclear Medicine and Biology. 20: 777-794. PMID 8401379 DOI: 10.1016/0969-8051(93)90165-Q |
0.378 |
|
| 1993 |
Mach RH, Luedtke RR, Unsworth CD, Boundy VA, Nowak PA, Scripko JG, Elder ST, Jackson JR, Hoffman PL, Evora PH. 18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography. Journal of Medicinal Chemistry. 36: 3707-20. PMID 8246241 DOI: 10.1021/Jm00075A028 |
0.425 |
|
| 1993 |
Chumpradit S, Kung MP, Billings J, Mach R, Kung HF. Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT. Journal of Medicinal Chemistry. 36: 221-8. PMID 8093734 DOI: 10.1021/Jm00054A005 |
0.415 |
|
| 1992 |
Mach RH, Jackson JR, Luedtke RR, Ivins KJ, Molinoff PB, Ehrenkaufer RL. Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors. Journal of Medicinal Chemistry. 35: 423-30. PMID 1531364 DOI: 10.1021/Jm00081A002 |
0.381 |
|
| 1990 |
Anderson WK, Mach RH. Synthesis and chemical reactivity of c‐5 substituted 6,7‐bis‐(hydroxymethyl)‐1H‐pyrrolizine biscarbamate tumor inhibitors Journal of Heterocyclic Chemistry. 27: 1025-1030. DOI: 10.1002/Jhet.5570270440 |
0.57 |
|
| 1990 |
ANDERSON WK, MACH RH. ChemInform Abstract: Vinylogous Carbinolamine Tumor Inhibitors. Part 25. Synthesis and Chemical Reactivity of C-5 Substituted 6,7-Bis(hydroxymethyl)-1H-pyrrolizine Biscarbamate Tumor Inhibitors. Cheminform. 21. DOI: 10.1002/chin.199049165 |
0.514 |
|
| 1988 |
Kung HF, Billings JJ, Guo YZ, Mach RH. Comparison of in vivo d-2 dopamine receptor binding of IBZM and NMSP in rat brain Nuclear Medicine and Biology. 15: 203-208. PMID 2966783 DOI: 10.1016/0883-2897(88)90089-X |
0.34 |
|
| 1988 |
Kung HF, Kasliwal R, Pan S, Kung MP, Mach RH, Guo YZ. Dopamine D-2 receptor imaging radiopharmaceuticals: Synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide Journal of Medicinal Chemistry. 31: 1039-1043. PMID 2966245 DOI: 10.1021/Jm00400A027 |
0.397 |
|
| 1988 |
Kung HF, Guo YZ, Billings J, Xu X, Mach RH, Blau M, Ackerhalt RE. Preparation and biodistribution of [125I]IBZM: A potential CNS D-2 dopamine receptor imaging agent International Journal of Radiation Applications and Instrumentation.. 15. DOI: 10.1016/0883-2897(88)90088-8 |
0.382 |
|
| 1988 |
ANDERSON WK, MACH RH. ChemInform Abstract: Vinylogous Carbinolamine Tumor Inhibitors. Part 21. Synthesis, Chemical Reactivity, and Antileukemic Activity of 5-Substituted 6,7-Bis(hydroxymethyl)pyrrolo(1,2-c)thiazole Biscarbamates and the Corresponding Sulfoxides and Sulfones. Cheminform. 19. DOI: 10.1002/chin.198815184 |
0.523 |
|
| 1987 |
Anderson WK, Mach RH. Synthesis, chemical reactivity, and antileukemic activity of 5-substituted 6,7-bis(hydroxymethyl)pyrrolo[1,2-c]thiazole biscarbamates and the corresponding sulfoxides and sulfones Journal of Medicinal Chemistry. 30: 2109-2115. PMID 3669018 DOI: 10.1021/Jm00394A030 |
0.535 |
|
| 1986 |
Anderson WK, Mach RH. Selective reduction of carboxylic acid esters in the presence of a five-membered cyclic sulfone Synthetic Communications. 16: 911-915. DOI: 10.1080/00397918608077293 |
0.516 |
|
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