| Year |
Citation |
Score |
| 2020 |
Duval S, Abu-Thuraia A, Elkholi IE, Chen R, Seebun D, Mayne J, Côté JF, Figeys D, Seidah NG. Shedding of cancer susceptibility candidate 4 by the convertases PC7/furin unravels a novel secretory protein implicated in cancer progression. Cell Death & Disease. 11: 665. PMID 32820145 DOI: 10.1038/S41419-020-02893-0 |
0.328 |
|
| 2020 |
Gan ES, Tan HC, Duyen HLT, Trieu HT, Wills B, Ooi EE, Seidah NG, Yacoub S. Dengue virus induces PCSK9 expression to alter antiviral responses and disease outcomes. The Journal of Clinical Investigation. PMID 32644974 DOI: 10.1172/Jci137536 |
0.335 |
|
| 2020 |
Löw K, Ducrest AL, San-Jose LM, Simon C, Uva V, Seidah NG, Pasquato A, Kunz S, Roulin A. Molecular evolution of the proopiomelanocortin system in Barn owl species. Plos One. 15: e0231163. PMID 32369484 DOI: 10.1371/Journal.Pone.0231163 |
0.302 |
|
| 2020 |
Ashraf Y, Duval S, Sachan V, Essalmani R, Susan-Resiga D, Roubtsova A, Hamelin J, Gerhardy S, Kirchhofer D, Tagliabracci VS, Prat A, Kiss RS, Seidah NG. Proprotein Convertase 7 (PCSK7) Reduces apoA-V Levels. The Febs Journal. PMID 31945259 DOI: 10.1111/Febs.15212 |
0.353 |
|
| 2020 |
Durand L, Duval S, Evagelidis A, Guillemot J, Dianati V, Sikorska E, Schu P, Day R, Seidah NG. The motif ExExxxL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity. The Journal of Biological Chemistry. PMID 31915245 DOI: 10.1074/Jbc.Ra119.011775 |
0.353 |
|
| 2019 |
Ben Djoudi Ouadda A, Gauthier MS, Susan-Resiga D, Girard E, Essalmani R, Black M, Marcinkiewicz J, Forget D, Hamelin J, Evagelidis A, Ly K, Day R, Galarneau L, Corbin F, Coulombe B, ... ... Seidah NG, et al. Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor). Arteriosclerosis, Thrombosis, and Vascular Biology. 39: 1996-2013. PMID 31553664 DOI: 10.1161/Atvbaha.119.313247 |
0.353 |
|
| 2019 |
Mikaeeli S, Susan-Resiga D, Girard E, Ben Djoudi Ouadda A, Day R, Prost S, Seidah NG. Functional analysis of natural PCSK9 mutants in modern and archaic humans. The Febs Journal. PMID 31386798 DOI: 10.1111/Febs.15036 |
0.311 |
|
| 2019 |
Löw K, Hardes K, Fedeli C, Seidah NG, Constam DB, Pasquato A, Steinmetzer T, Roulin A, Kunz S. A novel cell-based sensor detecting the activity of individual basic proprotein convertases. The Febs Journal. PMID 31276291 DOI: 10.1111/Febs.14979 |
0.315 |
|
| 2019 |
Lebeau PF, Byun JH, Platko K, MacDonald ME, Poon SV, Faiyaz M, Seidah NG, Austin RC. Diet-induced hepatic steatosis abrogates cell-surface LDLR by inducing de novo PCSK9 expression in mice. The Journal of Biological Chemistry. PMID 31004037 DOI: 10.1074/Jbc.Ra119.008094 |
0.321 |
|
| 2019 |
Sachan V, Lodge R, Mihara K, Hamelin J, Power C, Gelman BB, Hollenberg MD, Cohen ÉA, Seidah NG. HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin. Cell Death and Differentiation. PMID 30683917 DOI: 10.1038/S41418-018-0264-7 |
0.321 |
|
| 2019 |
Seidah NG, Prat A, Pirillo A, Catapano AL, Norata GD. Novel strategies to target PCSK9: beyond monoclonal antibodies. Cardiovascular Research. PMID 30629143 DOI: 10.1093/Cvr/Cvz003 |
0.324 |
|
| 2018 |
Essalmani R, Weider E, Marcinkiewicz J, Chamberland A, Susan-Resig D, Roubtsova A, Seidah NG, Prat A. A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice. Biological Chemistry. PMID 30044755 DOI: 10.1515/Hsz-2018-0194 |
0.336 |
|
| 2018 |
Grin PM, Dwivedi DJ, Chathely KM, Trigatti BL, Prat A, Seidah NG, Liaw PC, Fox-Robichaud AE. Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor. Scientific Reports. 8: 10496. PMID 30002483 DOI: 10.1038/S41598-018-28777-0 |
0.333 |
|
| 2018 |
Gauthier MS, Awan Z, Bouchard A, Champagne J, Tessier S, Faubert D, Chabot K, Garneau PY, Rabasa-Lhoret R, Seidah NG, Ridker PM, Genest J, Coulombe B. Posttranslational modification of proprotein convertase subtilisin/kexin type 9 is differentially regulated in response to distinct cardiometabolic treatments as revealed by targeted proteomics. Journal of Clinical Lipidology. PMID 29699916 DOI: 10.1016/J.Jacl.2018.03.092 |
0.591 |
|
| 2018 |
Lebeau P, Platko K, Al-Hashimi AA, Byun JH, Lhoták Š, Holzapfel N, Gyulay G, Igdoura SA, Cool D, Trigatti B, Seidah NG, Austin RC. Loss-of-function PCSK9 mutants evade the unfolded protein response sensor, GRP78, and fail to induce endoplasmic reticulum stress when retained. The Journal of Biological Chemistry. PMID 29593095 DOI: 10.1016/J.Atherosclerosissup.2018.04.426 |
0.31 |
|
| 2018 |
Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, et al. Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions. The Journal of Biological Chemistry. PMID 29559555 DOI: 10.1074/Jbc.M117.817981 |
0.315 |
|
| 2017 |
Hoac B, Susan-Resiga D, Essalmani R, Marcinkiweicz E, Seidah NG, McKee MD. Osteopontin as a novel substrate for the proprotein convertase 5/6 (PCSK5) in bone. Bone. PMID 29126984 DOI: 10.1016/J.Bone.2017.11.002 |
0.322 |
|
| 2017 |
Essalmani R, Susan-Resiga D, Guillemot J, Kim W, Sachan V, Awan Z, Chamberland A, Asselin MC, Ly K, Desjardins R, Day R, Prat A, Seidah NG. Thrombin activation of protein C requires prior processing by a liver proprotein convertase. The Journal of Biological Chemistry. 292: 13565. PMID 28821605 DOI: 10.1074/jbc.A116.77040 |
0.48 |
|
| 2017 |
Romagnuolo R, Scipione CA, Marcovina SM, Gemin M, Seidah NG, Boffa MB, Koschinsky ML. Roles of the low density lipoprotein receptor and related receptors in inhibition of lipoprotein(a) internalization by proprotein convertase subtilisin/kexin type 9. Plos One. 12: e0180869. PMID 28750079 DOI: 10.1371/Journal.Pone.0180869 |
0.317 |
|
| 2017 |
Paquette M, Luna Saavedra YG, Chamberland A, Prat A, Christensen DL, Lajeunesse-Trempe F, Kaduka L, Seidah NG, Dufour R, Baass A. Association Between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and the Presence of Metabolic Syndrome in a Predominantly Rural-Based Sub-Saharan African Population. Metabolic Syndrome and Related Disorders. PMID 28749722 DOI: 10.1089/met.2017.0027 |
0.724 |
|
| 2017 |
Essalmani R, Susan-Resiga D, Guillemot J, WooJin K, Sachan V, Awan Z, Chamberland A, Asselin MC, Ly K, Desjardins R, Day R, Prat A, Seidah NG. Thrombin Activation of Protein C Requires Prior Processing by a Liver Proprotein Convertase. The Journal of Biological Chemistry. PMID 28468828 DOI: 10.1074/Jbc.M116.770040 |
0.578 |
|
| 2016 |
Susan-Resiga D, Girard E, Kiss RS, Essalmani R, Hamelin J, Asselin MC, Awan Z, Butkinaree C, Fleury A, Soldera A, Dory YL, Baass A, Seidah NG. A novel mechanism causing familial hypercholesterolemia: The proprotein convertase subtilisin/kexin type 9-resistant Arg410Ser LDL receptor mutation. The Journal of Biological Chemistry. PMID 27998977 DOI: 10.1074/Jbc.M116.769430 |
0.581 |
|
| 2016 |
Lebeau P, Al-Hashimi A, Sood S, Lhotak S, Yu P, Gyulay G, Pare G, Chen SR, Trigatti B, Pratt A, Seidah N, Austin RC. Endoplasmic reticulum stress and Ca2+ depletion differentially modulate the sterol-regulatory protein PCSK9 to control lipid metabolism. The Journal of Biological Chemistry. PMID 27909053 DOI: 10.1074/Jbc.M116.744235 |
0.339 |
|
| 2016 |
Ly K, Essalmani R, Desjardins R, Seidah NG, Day R. An Unbiased Mass Spectrometry Approach Identifies Glypican-3 as an Interactor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and LDL Receptor in Hepatocellular Carcinoma Cells. The Journal of Biological Chemistry. PMID 27758865 DOI: 10.1074/Jbc.M116.746883 |
0.351 |
|
| 2016 |
Dwivedi DJ, Grin PM, Khan M, Prat A, Zhou J, Fox-Robichaud AE, Seidah NG, Liaw PC. Differential Expression of PCSK9 Modulates Infection, Inflammation and Coagulation in a Murine Model of Sepsis. Shock (Augusta, Ga.). PMID 27405064 DOI: 10.1097/Shk.0000000000000682 |
0.31 |
|
| 2016 |
Weider E, Susan-Resiga D, Essalmani R, Hamelin J, Asselin MC, Ashraf Y, Wycoff KL, Zhang J, Prat A, Seidah NG. Proprotein convertase subtilisin/Kexin type 9 (PCSK9) single domain antibodies are potent inhibitors of LDL receptor degradation. The Journal of Biological Chemistry. PMID 27284008 DOI: 10.1074/Jbc.M116.717736 |
0.339 |
|
| 2016 |
Seidah NG. New developments in proprotein convertase subtilisin-kexin 9's biology and clinical implications. Current Opinion in Lipidology. PMID 27031271 DOI: 10.1097/Mol.0000000000000295 |
0.334 |
|
| 2016 |
Awan Z, Denis M, Roubtsova A, Essalmani R, Marcinkiewicz J, Awan A, Gram H, Seidah NG, Genest J. Reducing Vascular Calcification by Anti-IL-1β Monoclonal Antibody in a Mouse Model of Familial Hypercholesterolemia. Angiology. 67: 157-67. PMID 25904765 DOI: 10.1177/0003319715583205 |
0.545 |
|
| 2016 |
Da Palma JR, Cendron L, Seidah NG, Pasquato A, Kunz S. Mechanism of folding and activation of subtilisin kexin isozyme-1 (SKI-1)/site-1 protease (S1P) Journal of Biological Chemistry. 291: 2055-2066. DOI: 10.1074/Jbc.M115.677757 |
0.317 |
|
| 2015 |
Bhat M, Skill N, Marcus V, Deschenes M, Tan X, Bouteaud J, Negi S, Awan Z, Aikin R, Kwan J, Amre R, Tabaries S, Hassanain M, Seidah NG, Maluccio M, et al. Decreased PCSK9 expression in human hepatocellular carcinoma. Bmc Gastroenterology. 15: 176. PMID 26674961 DOI: 10.1186/S12876-015-0371-6 |
0.537 |
|
| 2015 |
Pandruvada SN, Beauregard J, Benjannet S, Pata M, Lazure C, Seidah NG, Vacher J. Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking. Molecular and Cellular Biology. 36: 507-21. PMID 26598607 DOI: 10.1128/Mcb.00656-15 |
0.32 |
|
| 2015 |
Armstrong SM, Sugiyama MG, Fung KY, Gao Y, Wang C, Levy AS, Azizi P, Roufaiel M, Zhu SN, Neculai D, Yin C, Bolz SS, Seidah NG, Cybulsky MI, Heit B, et al. A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis. Cardiovascular Research. PMID 26334034 DOI: 10.1093/Cvr/Cvv218 |
0.313 |
|
| 2015 |
Roubtsova A, Chamberland A, Marcinkiewicz J, Essalmani R, Fazel A, Bergeron JJ, Seidah NG, Prat A. PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice. Journal of Lipid Research. 56: 2133-42. PMID 26323289 DOI: 10.1194/Jlr.M061952 |
0.313 |
|
| 2015 |
Kim W, Zekas E, Lodge R, Susan-Resiga D, Marcinkiewicz E, Essalmani R, Mihara K, Ramachandran R, Asahchop E, Gelman B, Cohen ÉA, Power C, Hollenberg MD, Seidah NG. Neuroinflammation-induced interactions between protease-activated receptor 1 and proprotein convertases in HIV-associated neurocognitive disorder. Molecular and Cellular Biology. PMID 26283733 DOI: 10.1128/Mcb.00764-15 |
0.309 |
|
| 2015 |
Le QT, Blanchet M, Seidah NG, Labonté P. Plasma Membrane Tetraspanin CD81 Complexes with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR), and Its Levels Are Reduced by PCSK9. The Journal of Biological Chemistry. 290: 23385-400. PMID 26195630 DOI: 10.1074/Jbc.M115.642991 |
0.317 |
|
| 2015 |
Butkinaree C, Canuel M, Essalmani R, Poirier S, Benjannet S, Asselin MC, Roubtsova A, Hamelin J, Marcinkiewicz J, Chamberland A, Guillemot J, Mayer G, Sisodia SS, Jacob Y, Prat A, ... Seidah NG, et al. Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other. The Journal of Biological Chemistry. 290: 18609-20. PMID 26085104 DOI: 10.1074/Jbc.M115.647180 |
0.628 |
|
| 2015 |
Bamimore MA, Zaid A, Banerjee Y, Al-Sarraf A, Abifadel M, Seidah NG, Al-Waili K, Al-Rasadi K, Awan Z. Familial hypercholesterolemia mutations in the Middle Eastern and North African region: a need for a national registry. Journal of Clinical Lipidology. 9: 187-94. PMID 25911074 DOI: 10.1016/J.Jacl.2014.11.008 |
0.511 |
|
| 2015 |
Romagnuolo R, Scipione CA, Boffa MB, Marcovina SM, Seidah NG, Koschinsky ML. Lipoprotein(a) catabolism is regulated by proprotein convertase subtilisin/kexin type 9 through the low density lipoprotein receptor. The Journal of Biological Chemistry. 290: 11649-62. PMID 25778403 DOI: 10.1074/Jbc.M114.611988 |
0.301 |
|
| 2015 |
Gauthier MS, Pérusse JR, Awan Z, Bouchard A, Tessier S, Champagne J, Krastins B, Byram G, Chabot K, Garneau P, Rabasa-Lhoret R, Faubert D, Lopez MF, Seidah NG, Coulombe B. A semi-automated mass spectrometric immunoassay coupled to selected reaction monitoring (MSIA-SRM) reveals novel relationships between circulating PCSK9 and metabolic phenotypes in patient cohorts. Methods (San Diego, Calif.). 81: 66-73. PMID 25770357 DOI: 10.1016/J.Ymeth.2015.03.003 |
0.587 |
|
| 2015 |
Dong B, Singh AB, Azhar S, Seidah NG, Liu J. High-fructose feeding promotes accelerated degradation of hepatic LDL receptor and hypercholesterolemia in hamsters via elevated circulating PCSK9 levels. Atherosclerosis. 239: 364-74. PMID 25682035 DOI: 10.1016/J.Atherosclerosis.2015.01.013 |
0.312 |
|
| 2014 |
da Palma JR, Burri DJ, Oppliger J, Salamina M, Cendron L, de Laureto PP, Seidah NG, Kunz S, Pasquato A. Zymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease. The Journal of Biological Chemistry. 289: 35743-56. PMID 25378398 DOI: 10.1074/Jbc.M114.588525 |
0.308 |
|
| 2014 |
Guillemot J, Essalmani R, Hamelin J, Seidah NG. Is there a link between proprotein convertase PC7 activity and human lipid homeostasis? Febs Open Bio. 4: 741-5. PMID 25349778 DOI: 10.1016/J.Fob.2014.08.004 |
0.364 |
|
| 2014 |
Duell PB, Dubuc G, Seidah NG, Davignon J. Clearance of plasma proprotein convertase subtilisin/kexin 9 by low-density lipoprotein apheresis. Circulation Research. 115: e3-4. PMID 24951769 DOI: 10.1161/Circresaha.114.304163 |
0.324 |
|
| 2014 |
Ly K, Saavedra YG, Canuel M, Routhier S, Desjardins R, Hamelin J, Mayne J, Lazure C, Seidah NG, Day R. Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9. The Journal of Biological Chemistry. 289: 17732-46. PMID 24808179 DOI: 10.1074/Jbc.M113.541094 |
0.343 |
|
| 2014 |
Pedersen NB, Wang S, Narimatsu Y, Yang Z, Halim A, Schjoldager KTBG, Madsen TD, Seidah NG, Bennett EP, Levery SB, Clausen H. Low density lipoprotein receptor class A repeats are O-glycosylated in linker regions Journal of Biological Chemistry. 289: 17312-17324. PMID 24798328 DOI: 10.1074/Jbc.M113.545053 |
0.31 |
|
| 2014 |
Awan Z, Dubuc G, Faraj M, Dufour R, Seidah NG, Davignon J, Rabasa-Lhoret R, Baass A. The effect of insulin on circulating PCSK9 in postmenopausal obese women. Clinical Biochemistry. 47: 1033-9. PMID 24721682 DOI: 10.1016/J.Clinbiochem.2014.03.022 |
0.565 |
|
| 2014 |
Seidah NG, Awan Z, Chrétien M, Mbikay M. PCSK9: a key modulator of cardiovascular health. Circulation Research. 114: 1022-36. PMID 24625727 DOI: 10.1161/Circresaha.114.301621 |
0.541 |
|
| 2014 |
Harihar S, Pounds KM, Iwakuma T, Seidah NG, Welch DR. Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing. Plos One. 9: e84958. PMID 24454770 DOI: 10.1371/Journal.Pone.0084958 |
0.336 |
|
| 2014 |
Harihar S, Hampton KR, Iwakuma T, Seidah NG, Welch DR. Abstract 135: Phosphorylation and furin-mediated processing are critical posttranslational modifications of the KISS1 metastasis suppressor Cancer Research. 74: 135-135. DOI: 10.1158/1538-7445.Am2014-135 |
0.336 |
|
| 2014 |
Awan Z, Dubuc G, Faraj M, Dufour R, Seidah N, Davignon J, Rabasa-Lhoret R, Baass A. Insulin Infusion Acutely Downregulates Circulating PCSK9 in Human* Journal of Clinical Lipidology. 8: 302. DOI: 10.1016/J.Jacl.2014.02.022 |
0.504 |
|
| 2013 |
Awan Z, Choi HY, Stitziel N, Ruel I, Bamimore MA, Husa R, Gagnon MH, Wang RH, Peloso GM, Hegele RA, Seidah NG, Kathiresan S, Genest J. APOE p.Leu167del mutation in familial hypercholesterolemia. Atherosclerosis. 231: 218-22. PMID 24267230 DOI: 10.1016/J.Cjca.2013.07.652 |
0.545 |
|
| 2013 |
Wetsel WC, Rodriguiz RM, Guillemot J, Rousselet E, Essalmani R, Kim IH, Bryant JC, Marcinkiewicz J, Desjardins R, Day R, Constam DB, Prat A, Seidah NG. Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. Proceedings of the National Academy of Sciences of the United States of America. 110: 17362-7. PMID 24101515 DOI: 10.1073/Pnas.1314698110 |
0.314 |
|
| 2013 |
Saavedra YG, Zhang J, Seidah NG. PCSK9 prosegment chimera as novel inhibitors of LDLR degradation. Plos One. 8: e72113. PMID 23951290 DOI: 10.1371/Journal.Pone.0072113 |
0.388 |
|
| 2013 |
Essalmani R, Susan-Resiga D, Chamberland A, Asselin MC, Canuel M, Constam D, Creemers JW, Day R, Gauthier D, Prat A, Seidah NG. Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. The Journal of Biological Chemistry. 288: 26410-8. PMID 23918928 DOI: 10.1074/Jbc.M113.501304 |
0.382 |
|
| 2013 |
Seidah NG, Sadr MS, Chrétien M, Mbikay M. The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions. The Journal of Biological Chemistry. 288: 21473-81. PMID 23775089 DOI: 10.1074/Jbc.R113.481549 |
0.356 |
|
| 2013 |
Awan Z, Delvin EE, Levy E, Genest J, Davignon J, Seidah NG, Baass A. Regional distribution and metabolic effect of PCSK9 insLEU and R46L gene mutations and apoE genotype. The Canadian Journal of Cardiology. 29: 927-33. PMID 23743349 DOI: 10.1016/J.Cjca.2013.03.004 |
0.544 |
|
| 2013 |
Canuel M, Sun X, Asselin MC, Paramithiotis E, Prat A, Seidah NG. Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1). Plos One. 8: e64145. PMID 23675525 DOI: 10.1371/Journal.Pone.0064145 |
0.37 |
|
| 2013 |
Berthold HK, Seidah NG, Benjannet S, Gouni-Berthold I. Evidence from a randomized trial that simvastatin, but not ezetimibe, upregulates circulating PCSK9 levels. Plos One. 8: e60095. PMID 23544125 DOI: 10.1371/Journal.Pone.0060095 |
0.341 |
|
| 2013 |
Levy E, Ben Djoudi Ouadda A, Spahis S, Sane AT, Garofalo C, Grenier É, Emonnot L, Yara S, Couture P, Beaulieu JF, Ménard D, Seidah NG, Elchebly M. PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells. Atherosclerosis. 227: 297-306. PMID 23422832 DOI: 10.1016/J.Atherosclerosis.2013.01.023 |
0.339 |
|
| 2013 |
Guillemot J, Canuel M, Essalmani R, Prat A, Seidah NG. Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin. Hepatology (Baltimore, Md.). 57: 2514-24. PMID 23390091 DOI: 10.1002/Hep.26297 |
0.34 |
|
| 2013 |
Poirier S, Mayer G, Murphy SR, Garver WS, Chang TY, Schu P, Seidah NG. The cytosolic adaptor AP-1A is essential for the trafficking and function of Niemann-Pick type C proteins. Traffic (Copenhagen, Denmark). 14: 458-69. PMID 23350547 DOI: 10.1111/Tra.12046 |
0.588 |
|
| 2013 |
Fantus D, Awan Z, Seidah NG, Genest J. Aortic calcification: Novel insights from familial hypercholesterolemia and potential role for the low-density lipoprotein receptor. Atherosclerosis. 226: 9-15. PMID 23040868 DOI: 10.1016/J.Atherosclerosis.2012.08.026 |
0.564 |
|
| 2013 |
Harihar S, Pounds KM, Iwakuma T, Seidah NG, Welch DR. Abstract 3860: Furin is required for processing KISS1 to kisspeptins. Cancer Research. 73: 3860-3860. DOI: 10.1158/1538-7445.Am2013-3860 |
0.336 |
|
| 2012 |
Sun X, Essalmani R, Day R, Khatib AM, Seidah NG, Prat A. Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver. Neoplasia (New York, N.Y.). 14: 1122-31. PMID 23308045 DOI: 10.1593/Neo.121252 |
0.332 |
|
| 2012 |
Saavedra YG, Day R, Seidah NG. The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway. The Journal of Biological Chemistry. 287: 43492-501. PMID 23105118 DOI: 10.1074/Jbc.M112.394023 |
0.349 |
|
| 2012 |
Maret D, Sadr MS, Sadr ES, Colman DR, Del Maestro RF, Seidah NG. Opposite roles of furin and PC5A in N-cadherin processing. Neoplasia (New York, N.Y.). 14: 880-92. PMID 23097623 DOI: 10.1593/Neo.121250 |
0.331 |
|
| 2012 |
Benjannet S, Hamelin J, Chrétien M, Seidah NG. Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation. The Journal of Biological Chemistry. 287: 33745-55. PMID 22875854 DOI: 10.1074/Jbc.M112.399725 |
0.363 |
|
| 2012 |
Seidah NG, Poirier S, Denis M, Parker R, Miao B, Mapelli C, Prat A, Wassef H, Davignon J, Hajjar KA, Mayer G. Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation. Plos One. 7: e41865. PMID 22848640 DOI: 10.1371/Journal.Pone.0041865 |
0.624 |
|
| 2012 |
Abifadel M, Guerin M, Benjannet S, Rabès JP, Le Goff W, Julia Z, Hamelin J, Carreau V, Varret M, Bruckert E, Tosolini L, Meilhac O, Couvert P, Bonnefont-Rousselot D, Chapman J, ... ... Seidah NG, et al. Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia. Atherosclerosis. 223: 394-400. PMID 22683120 DOI: 10.1016/J.Atherosclerosis.2012.04.006 |
0.303 |
|
| 2012 |
Seidah NG, Prat A. The biology and therapeutic targeting of the proprotein convertases. Nature Reviews. Drug Discovery. 11: 367-83. PMID 22679642 DOI: 10.1038/Nrd3699 |
0.365 |
|
| 2012 |
Refaie S, Gagnon S, Gagnon H, Desjardins R, D'Anjou F, D'Orléans-Juste P, Zhu X, Steiner DF, Seidah NG, Lazure C, Salzet M, Day R. Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion. The Journal of Biological Chemistry. 287: 14703-17. PMID 22396549 DOI: 10.1074/Jbc.M111.323220 |
0.311 |
|
| 2012 |
Zandberg WF, Gao N, Kumarasamy J, Lehrman MA, Seidah NG, Pinto BM. 5-thiomannosides block the biosynthesis of dolichol-linked oligosaccharides and mimic class I congenital disorders of glycosylation. Chembiochem : a European Journal of Chemical Biology. 13: 392-401. PMID 22262650 DOI: 10.1002/Cbic.201100647 |
0.338 |
|
| 2012 |
Denis M, Marcinkiewicz J, Zaid A, Gauthier D, Poirier S, Lazure C, Seidah NG, Prat A. Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice. Circulation. 125: 894-901. PMID 22261195 DOI: 10.1161/Circulationaha.111.057406 |
0.606 |
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| 2012 |
Awan Z, Seidah NG, MacFadyen JG, Benjannet S, Chasman DI, Ridker PM, Genest J. Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial. Clinical Chemistry. 58: 183-9. PMID 22065156 DOI: 10.1373/Clinchem.2011.172932 |
0.556 |
|
| 2012 |
Seidah NG, Chrétien M. Proprotein and prohormone convertases of the subtilisin family Recent developments and future perspectives. Trends in Endocrinology and Metabolism: Tem. 3: 133-40. PMID 18407092 DOI: 10.1016/1043-2760(92)90102-7 |
0.362 |
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| 2012 |
Seidah NG, Poirier S, Denis M, Parker R, Miao B, Mapelli C, Prat A, Wassef H, Davignon J, Hajjar KA, Mayer G. Adenoviral overexpression of AnxA2 in mouse liver significantly increases LDLR levels. Plos One. DOI: 10.1371/Journal.Pone.0041865.G005 |
0.536 |
|
| 2011 |
Awan Z, Denis M, Bailey D, Giaid A, Prat A, Goltzman D, Seidah NG, Genest J. The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography. Atherosclerosis. 219: 455-62. PMID 22051553 DOI: 10.1016/J.Atherosclerosis.2011.08.035 |
0.553 |
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| 2011 |
Mayne J, Dewpura T, Raymond A, Bernier L, Cousins M, Ooi TC, Davignon J, Seidah NG, Mbikay M, Chrétien M. Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture. Clinical Chemistry. 57: 1415-23. PMID 21813713 DOI: 10.1373/Clinchem.2011.165191 |
0.352 |
|
| 2011 |
Sun X, Essalmani R, Susan-Resiga D, Prat A, Seidah NG. Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A. The Journal of Biological Chemistry. 286: 29063-73. PMID 21700711 DOI: 10.1074/Jbc.M111.242479 |
0.325 |
|
| 2011 |
Susan-Resiga D, Essalmani R, Hamelin J, Asselin MC, Benjannet S, Chamberland A, Day R, Szumska D, Constam D, Bhattacharya S, Prat A, Seidah NG. Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10. The Journal of Biological Chemistry. 286: 22785-94. PMID 21550985 DOI: 10.1074/Jbc.M111.233577 |
0.365 |
|
| 2011 |
Zandberg WF, Benjannet S, Hamelin J, Pinto BM, Seidah NG. N-glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1. Glycobiology. 21: 1290-300. PMID 21527438 DOI: 10.1093/Glycob/Cwr060 |
0.377 |
|
| 2011 |
Seidah NG. What lies ahead for the proprotein convertases? Annals of the New York Academy of Sciences. 1220: 149-61. PMID 21388412 DOI: 10.1111/J.1749-6632.2010.05883.X |
0.369 |
|
| 2011 |
Denis N, Palmer-Smith H, Elisma F, Busuttil A, Wright TG, Bou Khalil M, Prat A, Seidah NG, Chrétien M, Mayne J, Figeys D. Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells. Journal of Proteome Research. 10: 2011-26. PMID 21332221 DOI: 10.1021/Pr2000072 |
0.379 |
|
| 2011 |
Roubtsova A, Munkonda MN, Awan Z, Marcinkiewicz J, Chamberland A, Lazure C, Cianflone K, Seidah NG, Prat A. Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 785-91. PMID 21273557 DOI: 10.1161/Atvbaha.110.220988 |
0.571 |
|
| 2011 |
Rousselet E, Benjannet S, Marcinkiewicz E, Asselin MC, Lazure C, Seidah NG. Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor. The Journal of Biological Chemistry. 286: 9185-95. PMID 21209099 DOI: 10.1074/Jbc.M110.189936 |
0.343 |
|
| 2011 |
Essalmani R, Susan-Resiga D, Chamberland A, Abifadel M, Creemers JW, Boileau C, Seidah NG, Prat A. In vivo evidence that furin from hepatocytes inactivates PCSK9. The Journal of Biological Chemistry. 286: 4257-63. PMID 21147780 DOI: 10.1074/Jbc.M110.192104 |
0.396 |
|
| 2011 |
Tremblay AJ, Lamarche B, Lemelin V, Hoos L, Benjannet S, Seidah NG, Davis HR, Couture P. Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men. Journal of Lipid Research. 52: 558-65. PMID 21123766 DOI: 10.1194/Jlr.M011080 |
0.313 |
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| 2011 |
Rousselet E, Benjannet S, Hamelin J, Canuel M, Seidah NG. The proprotein convertase PC7: unique zymogen activation and trafficking pathways. The Journal of Biological Chemistry. 286: 2728-38. PMID 21075846 DOI: 10.1074/Jbc.M110.192344 |
0.343 |
|
| 2011 |
Gorski JP, Huffman NT, Chittur S, Midura RJ, Black C, Oxford J, Seidah NG. Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization. The Journal of Biological Chemistry. 286: 1836-49. PMID 21075843 DOI: 10.1074/Jbc.M110.151647 |
0.31 |
|
| 2010 |
Benjannet S, Saavedra YG, Hamelin J, Asselin MC, Essalmani R, Pasquato A, Lemaire P, Duke G, Miao B, Duclos F, Parker R, Mayer G, Seidah NG. Effects of the prosegment and pH on the activity of PCSK9: evidence for additional processing events. The Journal of Biological Chemistry. 285: 40965-78. PMID 20937814 DOI: 10.1074/Jbc.M110.154815 |
0.349 |
|
| 2010 |
Chitramuthu BP, Baranowski DC, Cadieux B, Rousselet E, Seidah NG, Bennett HP. Molecular cloning and embryonic expression of zebrafish PCSK5 co-orthologues: functional assessment during lateral line development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 239: 2933-46. PMID 20882679 DOI: 10.1002/Dvdy.22426 |
0.331 |
|
| 2010 |
Davignon J, Dubuc G, Seidah NG. The influence of PCSK9 polymorphisms on serum low-density lipoprotein cholesterol and risk of atherosclerosis. Current Atherosclerosis Reports. 12: 308-15. PMID 20623344 DOI: 10.1007/S11883-010-0123-6 |
0.349 |
|
| 2010 |
Gupta N, Fisker N, Asselin MC, Lindholm M, Rosenbohm C, Ørum H, Elmén J, Seidah NG, Straarup EM. A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo. Plos One. 5: e10682. PMID 20498851 DOI: 10.1371/Journal.Pone.0010682 |
0.349 |
|
| 2010 |
Levy E, Lalonde G, Delvin E, Elchebly M, Précourt LP, Seidah NG, Spahis S, Rabasa-Lhoret R, Ziv E. Intestinal and hepatic cholesterol carriers in diabetic Psammomys obesus. Endocrinology. 151: 958-70. PMID 20130116 DOI: 10.1210/En.2009-0866 |
0.344 |
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| 2010 |
Dong B, Wu M, Li H, Kraemer FB, Adeli K, Seidah NG, Park SW, Liu J. Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters. Journal of Lipid Research. 51: 1486-95. PMID 20048381 DOI: 10.1194/Jlr.M003566 |
0.34 |
|
| 2010 |
Mbikay M, Sirois F, Mayne J, Wang GS, Chen A, Dewpura T, Prat A, Seidah NG, Chretien M, Scott FW. PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities. Febs Letters. 584: 701-6. PMID 20026049 DOI: 10.1016/J.Febslet.2009.12.018 |
0.312 |
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| 2010 |
Dubuc G, Tremblay M, Paré G, Jacques H, Hamelin J, Benjannet S, Boulet L, Genest J, Bernier L, Seidah NG, Davignon J. A new method for measurement of total plasma PCSK9: clinical applications. Journal of Lipid Research. 51: 140-9. PMID 19571328 DOI: 10.1194/Jlr.M900273-Jlr200 |
0.319 |
|
| 2009 |
Iatan I, Dastani Z, Do R, Weissglas-Volkov D, Ruel I, Lee JC, Huertas-Vazquez A, Taskinen MR, Prat A, Seidah NG, Pajukanta P, Engert JC, Genest J. Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels. Circulation. Cardiovascular Genetics. 2: 467-75. PMID 20031622 DOI: 10.1161/Circgenetics.109.877811 |
0.334 |
|
| 2009 |
Poirier S, Mayer G, Poupon V, McPherson PS, Desjardins R, Ly K, Asselin MC, Day R, Duclos FJ, Witmer M, Parker R, Prat A, Seidah NG. Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route. The Journal of Biological Chemistry. 284: 28856-64. PMID 19635789 DOI: 10.1074/Jbc.M109.037085 |
0.626 |
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| 2009 |
Leblond F, Seidah NG, Précourt LP, Delvin E, Dominguez M, Levy E. Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 296: G805-15. PMID 19179626 DOI: 10.1152/Ajpgi.90424.2008 |
0.343 |
|
| 2009 |
Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G. Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. The Journal of Biological Chemistry. 284: 3793-803. PMID 19074428 DOI: 10.1074/Jbc.M808920200 |
0.337 |
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| 2009 |
Seidah NG. PCSK9 as a therapeutic target of dyslipidemia. Expert Opinion On Therapeutic Targets. 13: 19-28. PMID 19063703 DOI: 10.1517/14728220802600715 |
0.369 |
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| 2008 |
Mayer G, Poirier S, Seidah NG. Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels. The Journal of Biological Chemistry. 283: 31791-801. PMID 18799458 DOI: 10.1074/Jbc.M805971200 |
0.622 |
|
| 2008 |
Chrétien M, Seidah NG, Basak A, Mbikay M. Proprotein convertases as therapeutic targets. Expert Opinion On Therapeutic Targets. 12: 1289-300. PMID 18781827 DOI: 10.1517/14728222.12.10.1289 |
0.335 |
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| 2008 |
Zaid A, Roubtsova A, Essalmani R, Marcinkiewicz J, Chamberland A, Hamelin J, Tremblay M, Jacques H, Jin W, Davignon J, Seidah NG, Prat A. Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration. Hepatology (Baltimore, Md.). 48: 646-54. PMID 18666258 DOI: 10.1002/Hep.22354 |
0.336 |
|
| 2008 |
Ozden S, Lucas-Hourani M, Ceccaldi PE, Basak A, Valentine M, Benjannet S, Hamelin J, Jacob Y, Mamchaoui K, Mouly V, Desprès P, Gessain A, Butler-Browne G, Chrétien M, Tangy F, ... ... Seidah NG, et al. Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein. The Journal of Biological Chemistry. 283: 21899-908. PMID 18559340 DOI: 10.1074/Jbc.M802444200 |
0.301 |
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| 2008 |
Dewpura T, Raymond A, Hamelin J, Seidah NG, Mbikay M, Chrétien M, Mayne J. PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans. The Febs Journal. 275: 3480-93. PMID 18498363 DOI: 10.1111/J.1742-4658.2008.06495.X |
0.301 |
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| 2008 |
Essalmani R, Zaid A, Marcinkiewicz J, Chamberland A, Pasquato A, Seidah NG, Prat A. In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Proceedings of the National Academy of Sciences of the United States of America. 105: 5750-5. PMID 18378898 DOI: 10.1073/Pnas.0709428105 |
0.334 |
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| 2008 |
Seidah NG, Mayer G, Zaid A, Rousselet E, Nassoury N, Poirier S, Essalmani R, Prat A. The activation and physiological functions of the proprotein convertases. The International Journal of Biochemistry & Cell Biology. 40: 1111-25. PMID 18343183 DOI: 10.1016/J.Biocel.2008.01.030 |
0.634 |
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| 2008 |
Scamuffa N, Siegfried G, Bontemps Y, Ma L, Basak A, Cherel G, Calvo F, Seidah NG, Khatib AM. Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells. The Journal of Clinical Investigation. 118: 352-63. PMID 18064302 DOI: 10.1172/Jci32040 |
0.304 |
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| 2008 |
Xiao Y, Chen G, Richard J, Rougeau N, Li H, Seidah NG, Cohen EA. Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases. Virology. 372: 384-97. PMID 18061232 DOI: 10.1016/J.Virol.2007.10.036 |
0.319 |
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| 2008 |
Poirier S, Mayer G, Benjannet S, Bergeron E, Marcinkiewicz J, Nassoury N, Mayer H, Nimpf J, Prat A, Seidah NG. The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2. The Journal of Biological Chemistry. 283: 2363-72. PMID 18039658 DOI: 10.1074/Jbc.M708098200 |
0.622 |
|
| 2008 |
Mayer G, Hamelin J, Asselin MC, Pasquato A, Marcinkiewicz E, Tang M, Tabibzadeh S, Seidah NG. The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates. The Journal of Biological Chemistry. 283: 2373-84. PMID 18039650 DOI: 10.1074/Jbc.M708763200 |
0.33 |
|
| 2007 |
De Windt A, Rai M, Bernier L, Thelen K, Soini J, Lefebvre C, Chintawar S, Lavigne J, Saarinen L, Kytömäki L, Munzer JS, Lütjohann D, Pandolfo M, Davignon J, Seidah NG, et al. Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells. Dna and Cell Biology. 26: 765-72. PMID 17867930 DOI: 10.1089/Dna.2007.0624 |
0.341 |
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| 2007 |
Dikeakos JD, Mercure C, Lacombe MJ, Seidah NG, Reudelhuber TL. PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism. The Febs Journal. 274: 4094-102. PMID 17645548 DOI: 10.1111/J.1742-4658.2007.05937.X |
0.342 |
|
| 2007 |
Pullikotil P, Benjannet S, Mayne J, Seidah NG. The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization. The Journal of Biological Chemistry. 282: 27402-13. PMID 17623657 DOI: 10.1074/Jbc.M703200200 |
0.334 |
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| 2007 |
Billova S, Galanopoulou AS, Seidah NG, Qiu X, Kumar U. Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain Neuroscience. 147: 403-418. PMID 17543468 DOI: 10.1016/J.Neuroscience.2007.04.039 |
0.312 |
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| 2007 |
Mbikay M, Mayne J, Seidah NG, Chrétien M. Of PCSK9, cholesterol homeostasis and parasitic infections: possible survival benefits of loss-of-function PCSK9 genetic polymorphisms. Medical Hypotheses. 69: 1010-7. PMID 17502126 DOI: 10.1016/J.Mehy.2007.03.018 |
0.31 |
|
| 2007 |
Mbikay M, Croissandeau G, Sirois F, Anini Y, Mayne J, Seidah NG, Chrétien M. A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat. Developmental Biology. 306: 584-98. PMID 17490633 DOI: 10.1016/J.Ydbio.2007.03.523 |
0.319 |
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| 2007 |
Nassoury N, Blasiole DA, Tebon Oler A, Benjannet S, Hamelin J, Poupon V, McPherson PS, Attie AD, Prat A, Seidah NG. The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR. Traffic (Copenhagen, Denmark). 8: 718-32. PMID 17461796 DOI: 10.1111/J.1600-0854.2007.00562.X |
0.367 |
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| 2007 |
Seidah NG, Prat A. The proprotein convertases are potential targets in the treatment of dyslipidemia Journal of Molecular Medicine. 85: 685-696. PMID 17351764 DOI: 10.1007/S00109-007-0172-7 |
0.397 |
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| 2006 |
Guillemot J, Barbier L, Thouennon E, Vallet-Erdtmann V, Montero-Hadjadje M, Lefebvre H, Klein M, Muresan M, Plouin PF, Seidah N, Vaudry H, Anouar Y, Yon L. Expression and processing of the neuroendocrine protein secretogranin II in benign and malignant pheochromocytomas. Annals of the New York Academy of Sciences. 1073: 527-32. PMID 17102121 DOI: 10.1196/Annals.1353.056 |
0.302 |
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| 2006 |
Scamuffa N, Calvo F, Chrétien M, Seidah NG, Khatib AM. Proprotein convertases: Lessons from knockouts Faseb Journal. 20: 1954-1963. PMID 17012247 DOI: 10.1096/Fj.05-5491Rev |
0.369 |
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| 2006 |
Seidah NG, Khatib AM, Prat A. The proprotein convertases and their implication in sterol and/or lipid metabolism Biological Chemistry. 387: 871-877. PMID 16913836 DOI: 10.1515/Bc.2006.110 |
0.381 |
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| 2006 |
Benjannet S, Rhainds D, Hamelin J, Nassoury N, Seidah NG. The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: Functional consequences of natural mutations and post-translational modifications Journal of Biological Chemistry. 281: 30561-30572. PMID 16912035 DOI: 10.1074/Jbc.M606495200 |
0.372 |
|
| 2006 |
Poirier S, Prat A, Marcinkiewicz E, Paquin J, Chitramuthu BP, Baranowski D, Cadieux B, Bennett HPJ, Seidah NG. Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system Journal of Neurochemistry. 98: 838-850. PMID 16893422 DOI: 10.1111/J.1471-4159.2006.03928.X |
0.597 |
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| 2006 |
Pasquato A, Pullikotil P, Asselin MC, Vacatello M, Paolillo L, Ghezzo F, Basso F, Di Bello C, Dettin M, Seidah NG. The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors. The Journal of Biological Chemistry. 281: 23471-81. PMID 16790437 DOI: 10.1074/Jbc.M513675200 |
0.331 |
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| 2006 |
Essalmani R, Hamelin J, Marcinkiewicz J, Chamberland A, Mbikay M, Chrétien M, Seidah NG, Prat A. Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse Molecular and Cellular Biology. 26: 354-361. PMID 16354705 DOI: 10.1128/Mcb.26.1.354-361.2006 |
0.332 |
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| 2006 |
Siegfried G, Basak A, Prichett-Pejic W, Scamuffa N, Ma L, Benjannet S, Veinot JP, Calvo F, Seidah N, Khatib AM. Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases. Oncogene. 24: 6925-35. PMID 16007151 DOI: 10.1038/Sj.Onc.1208838 |
0.307 |
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| 2005 |
Salvas A, Benjannet S, Reudelhuber TL, Chrétien M, Seidah NG. Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi. Febs Letters. 579: 5621-5. PMID 16213495 DOI: 10.1016/J.Febslet.2005.09.029 |
0.317 |
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| 2005 |
Jin W, Fuki IV, Seidah NG, Benjannet S, Glick JM, Rader DJ. Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase. The Journal of Biological Chemistry. 280: 36551-9. PMID 16109723 DOI: 10.1074/Jbc.M502264200 |
0.389 |
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| 2005 |
Attie AD, Seidah NG. Dual regulation of the LDL receptor--some clarity and new questions. Cell Metabolism. 1: 290-2. PMID 16054075 DOI: 10.1016/J.Cmet.2005.04.006 |
0.326 |
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| 2005 |
De Cicco RL, Bassi DE, Zucker S, Seidah NG, Klein-Szanto AJP. Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin Cancer Research. 65: 4162-4171. PMID 15899807 DOI: 10.1158/0008-5472.Can-04-2820 |
0.313 |
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| 2005 |
Stawowy P, Kallisch H, Borges Pereira Stawowy N, Stibenz D, Veinot JP, Gräfe M, Seidah NG, Chrétien M, Fleck E, Graf K. Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis. Virchows Archiv : An International Journal of Pathology. 446: 351-9. PMID 15756593 DOI: 10.1007/S00428-004-1198-7 |
0.303 |
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| 2005 |
Lalanne F, Lambert G, Amar MJA, Chétiveaux M, Zaïr Y, Jarnoux AL, Ouguerram K, Friburg J, Seidah NG, Brewer HB, Krempf M, Costet P. Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells Journal of Lipid Research. 46: 1312-1319. PMID 15741654 DOI: 10.1194/Jlr.M400396-Jlr200 |
0.365 |
|
| 2005 |
Wickham L, Benjannet S, Marcinkiewicz E, Chretien M, Seidah NG. β-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: Binding partners processed by furin Journal of Neurochemistry. 92: 93-102. PMID 15606899 DOI: 10.1111/J.1471-4159.2004.02840.X |
0.301 |
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| 2005 |
Bergeron E, Vincent MJ, Wickham L, Hamelin J, Basak A, Nichol ST, Chrétien M, Seidah NG. Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus. Biochemical and Biophysical Research Communications. 326: 554-63. PMID 15596135 DOI: 10.1016/J.Bbrc.2004.11.063 |
0.328 |
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| 2004 |
Benjannet S, Cromlish JA, Diallo K, Chrétien M, Seidah NG. The metabolism of β-amyloid converting enzyme and β-amyloid precursor protein processing Biochemical and Biophysical Research Communications. 325: 235-242. PMID 15522224 DOI: 10.1016/J.Bbrc.2004.10.019 |
0.305 |
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| 2004 |
Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, ... ... Seidah NG, et al. NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. The Journal of Biological Chemistry. 279: 48865-75. PMID 15358785 DOI: 10.1074/Jbc.M409699200 |
0.37 |
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| 2004 |
Dubuc G, Chamberland A, Wassef H, Davignon J, Seidah NG, Bernier L, Prat A. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 1454-9. PMID 15178557 DOI: 10.1161/01.Atv.0000134621.14315.43 |
0.309 |
|
| 2004 |
Stawowy P, Kallisch H, Veinot JP, Kilimnik A, Prichett W, Goetze S, Seidah NG, Chrétien M, Fleck E, Graf K. Endoproteolytic Activation of αv Integrin by Proprotein Convertase PC5 Is Required for Vascular Smooth Muscle Cell Adhesion to Vitronectin and Integrin-Dependent Signaling Circulation. 109: 770-776. PMID 14970114 DOI: 10.1161/01.Cir.0000112583.50762.De |
0.32 |
|
| 2003 |
Winsky-Sommerer R, Grouselle D, Rougeot C, Laurent V, David JP, Delacourte A, Dournaud P, Seidah NG, Lindberg I, Trottier S, Epelbaum J. The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease. Neuroscience. 122: 437-47. PMID 14614908 DOI: 10.1016/S0306-4522(03)00560-8 |
0.312 |
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| 2003 |
Vincent MJ, Sanchez AJ, Erickson BR, Basak A, Chretien M, Seidah NG, Nichol ST. Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1. Journal of Virology. 77: 8640-9. PMID 12885882 DOI: 10.1128/Jvi.77.16.8640-8649.2003 |
0.322 |
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| 2003 |
Okada T, Haze K, Nadanaka S, Yoshida H, Seidah NG, Hirano Y, Sato R, Negishi M, Mori K. A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. The Journal of Biological Chemistry. 278: 31024-32. PMID 12782636 DOI: 10.1074/Jbc.M300923200 |
0.301 |
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| 2003 |
Abifadel M, Varret M, Rabès JP, Allard D, Ouguerram K, Devillers M, Cruaud C, Benjannet S, Wickham L, Erlich D, Derré A, Villéger L, Farnier M, Beucler I, Bruckert E, ... ... Seidah NG, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia Nature Genetics. 34: 154-156. PMID 12730697 DOI: 10.1038/Ng1161 |
0.335 |
|
| 2003 |
Stawowy P, Graf K, Goetze S, Roser M, Chrétien M, Seidah NG, Fleck E, Marcinkiewicz M. Coordinated regulation and colocalization of αv integrin and its activating enzyme proprotein convertase PC5 in vivo Histochemistry and Cell Biology. 119: 239-245. PMID 12649739 DOI: 10.1007/S00418-003-0506-7 |
0.325 |
|
| 2003 |
Doblinger A, Becker A, Seidah NG, Laslop A. Proteolytic processing of chromogranin A by the prohormone convertase PC2 Regulatory Peptides. 111: 111-116. PMID 12609757 DOI: 10.1016/S0167-0115(02)00262-8 |
0.364 |
|
| 2003 |
Seidah NG, Benjannet S, Wickham L, Marcinkiewicz J, Jasmin SB, Stifani S, Basak A, Prat A, Chretien M. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proceedings of the National Academy of Sciences of the United States of America. 100: 928-33. PMID 12552133 DOI: 10.1073/Pnas.0335507100 |
0.317 |
|
| 2003 |
Conesa M, Prat A, Mort JS, Marvaldi J, Lissitzky JC, Seidah NG. Down-regulation of αv/β3 integrin via misrouting to lysosomes by overexpression of a β3Lamp1 fusion protein Biochemical Journal. 370: 703-711. PMID 12444923 DOI: 10.1042/Bj20021301 |
0.304 |
|
| 2003 |
Nour N, Basak A, Chrétien M, Seidah NG. Structure-function analysis of the prosegment of the proprotein convertase PC5A. The Journal of Biological Chemistry. 278: 2886-95. PMID 12414802 DOI: 10.1074/Jbc.M208009200 |
0.323 |
|
| 2002 |
Seidah NG, Prat A. Precursor convertases in the secretory pathway, cytosol and extracellular milieu Essays in Biochemistry. 38: 79-94. PMID 12463163 DOI: 10.1042/Bse0380079 |
0.372 |
|
| 2002 |
Villeneuve P, Feliciangeli S, Croissandeau G, Seidah NG, Mbikay M, Kitabgi P, Beaudet A. Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study. Journal of Neurochemistry. 82: 783-93. PMID 12358783 DOI: 10.1046/J.1471-4159.2002.00988.X |
0.317 |
|
| 2002 |
Mbikay M, Raffin-Sanson ML, Sirois F, Kalenga L, Chrétien M, Seidah NG. Characterization of a repressor element in the promoter region of proprotein convertase 2 (PC2) gene. Brain Research. Molecular Brain Research. 102: 35-47. PMID 12191492 DOI: 10.1016/S0169-328X(02)00180-8 |
0.316 |
|
| 2002 |
Hospital V, Nishi E, Klagsbrun M, Cohen P, Seidah NG, Prat A. The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF). The Biochemical Journal. 367: 229-38. PMID 12095415 DOI: 10.1042/Bj20020822 |
0.302 |
|
| 2001 |
Elagoz A, Benjannet S, Mammarbassi A, Wickham L, Seidah NG. Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity. The Journal of Biological Chemistry. 277: 11265-75. PMID 11756446 DOI: 10.1074/Jbc.M109011200 |
0.346 |
|
| 2001 |
Lenz O, ter Meulen J, Klenk HD, Seidah NG, Garten W. The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P. Proceedings of the National Academy of Sciences of the United States of America. 98: 12701-5. PMID 11606739 DOI: 10.1073/Pnas.221447598 |
0.302 |
|
| 2001 |
Khatib AM, Siegfried G, Prat A, Luis J, Chrétien M, Metrakos P, Seidah NG. Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions. The Journal of Biological Chemistry. 276: 30686-93. PMID 11402025 DOI: 10.1074/Jbc.M101725200 |
0.321 |
|
| 2001 |
Lopez-Perez E, Zhang Y, Frank SJ, Creemers J, Seidah N, Checler F. Constitutive α-secretase cleavage of the β-amyloid precursor protein in the furin-deficient LoVo cell line: Involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10 Journal of Neurochemistry. 76: 1532-1539. PMID 11238737 DOI: 10.1046/J.1471-4159.2001.00180.X |
0.32 |
|
| 2001 |
Stawowy P, Marcinkiewicz J, Graf K, Seidah NG, Chrétien M, Fleck E, Marcinkiewicz M. Selective expression of the proprotein convertases furin, pc5, and pc7 in proliferating vascular smooth muscle cells of the rat aorta in vitro. Journal of Histochemistry and Cytochemistry. 49: 323-331. PMID 11181735 DOI: 10.1177/002215540104900306 |
0.318 |
|
| 2001 |
Nillni EA, Aird F, Seidah NG, Todd RB, Koenig JI. PreproTRH(178-199) and two novel peptides (pFQ7 and pSE14) derived from its processing, which are produced in the paraventricular nucleus of the rat hypothalamus, are regulated during suckling. Endocrinology. 142: 896-906. PMID 11159863 DOI: 10.1210/Endo.142.2.7954 |
0.349 |
|
| 2001 |
Benjannet S, Elagoz A, Wickham L, Mamarbachi M, Munzer JS, Basak A, Lazure C, Cromlish JA, Sisodia S, Checler F, Chrétien M, Seidah NG. Post-translational processing of β-secretase (β -amyloid-converting enzyme) and its ectodomain shedding: The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-β production Journal of Biological Chemistry. 276: 10879-10887. PMID 11152688 DOI: 10.1074/Jbc.M009899200 |
0.316 |
|
| 2001 |
MBIKAY M, SEIDAH NG, CHRÉTIEN M. Neuroendocrine secretory protein 7B2: structure, expression and functions Biochemical Journal. 357: 329-342. DOI: 10.1042/Bj3570329 |
0.389 |
|
| 2001 |
BASAK A, ZHONG M, MUNZER JS, CHRÉTIEN M, SEIDAH NG. Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides Biochemical Journal. 353: 537-545. DOI: 10.1042/0264-6021:3530537 |
0.326 |
|
| 2000 |
Villeneuve P, Seidah NG, Beaudet A. Immunohistochemical evidence for the implication of PC1 in the processing of proneurotensin in rat brain. Neuroreport. 11: 3443-7. PMID 11095496 DOI: 10.1097/00001756-200011090-00009 |
0.311 |
|
| 2000 |
Rovère C, Mort JS, Chrétien M, Seidah NG. Cathepsin-B fusion proteins misroute secretory protein partners such as the proprotein convertase PC2-7B2 complex toward the lysosomal degradation pathways. Biochemical and Biophysical Research Communications. 276: 594-9. PMID 11027518 DOI: 10.1006/Bbrc.2000.3478 |
0.328 |
|
| 2000 |
Jutras I, Seidah NG, Reudelhuber TL. A predicted alpha -helix mediates targeting of the proprotein convertase PC1 to the regulated secretory pathway. The Journal of Biological Chemistry. 275: 40337-43. PMID 11006274 DOI: 10.1074/Jbc.M004757200 |
0.323 |
|
| 2000 |
Hwang SR, Ng SM, Steineckert B, Seidah NG, Hook VY. Molecular cloning demonstrates structural features of homologous bovine prohormone convertases 1 and 2. Dna and Cell Biology. 19: 409-19. PMID 10945231 DOI: 10.1089/10445490050085906 |
0.323 |
|
| 2000 |
Villeneuve P, Lafortune L, Seidah NG, Kitabgi P, Beaudet A. Immunohistochemical evidence for the involvement of protein convertases 5A and 2 in the processing of pro-neurotensin in rat brain. The Journal of Comparative Neurology. 424: 461-75. PMID 10906713 DOI: 10.1002/1096-9861(20000828)424:3<461::Aid-Cne5>3.0.Co;2-J |
0.335 |
|
| 2000 |
Winsky-Sommerer R, Benjannet S, Rovère C, Barbero P, Seidah NG, Epelbaum J, Dournaud P. Regional and cellular localization of the neuroendocrine prohormone convertases PC1 and PC2 in the rat central nervous system Journal of Comparative Neurology. 424: 439-460. PMID 10906712 DOI: 10.1002/1096-9861(20000828)424:3<439::Aid-Cne4>3.0.Co;2-1 |
0.337 |
|
| 2000 |
Lesage G, Prat A, Lacombe J, Thomas DY, Seidah NG, Boileau G. The Kex2p proregion is essential for the biosynthesis of an active enzyme and requires a C-terminal basic residue for its function Molecular Biology of the Cell. 11: 1947-1957. PMID 10848621 DOI: 10.1091/Mbc.11.6.1947 |
0.331 |
|
| 2000 |
Seidah NG, Benjannet S, Hamelin J, Mamarbachi AM, Basak A, Marcinkiewicz J, Mbikay M, Chrétien M, Marcinkiewicz M. The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1. Annals of the New York Academy of Sciences. 885: 57-74. PMID 10816641 DOI: 10.1111/J.1749-6632.1999.Tb08665.X |
0.349 |
|
| 2000 |
Ghaddar G, Ruchon AF, Carpentier M, Marcinkiewicz M, Seidah NG, Crine P, Desgroseillers L, Boileau G. Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family Biochemical Journal. 347: 419-429. PMID 10749671 DOI: 10.1042/0264-6021:3470419 |
0.347 |
|
| 2000 |
Bhattacharjya S, Xu P, Zhong M, Chrétien M, Seidah NG, Ni F. Inhibitory activity and structural characterization of a C-terminal peptide fragment derived from the prosegment of the proprotein convertase PC7. Biochemistry. 39: 2868-77. PMID 10715106 DOI: 10.1021/Bi9923961 |
0.319 |
|
| 2000 |
Seidah NG, Chrétien M. Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Research. 848: 45-62. PMID 10701998 DOI: 10.1016/S0006-8993(99)01909-5 |
0.363 |
|
| 2000 |
Touré BB, Munzer JS, Basak A, Benjannet S, Rochemont J, Lazure C, Chrétien M, Seidah NG. Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment. The Journal of Biological Chemistry. 275: 2349-58. PMID 10644685 DOI: 10.1074/Jbc.275.4.2349 |
0.35 |
|
| 2000 |
Muller L, Picart R, Barret A, Seidah NG, Tougard C. Immunocytochemical localization of the prohormone convertases PC1 and PC2 in rat prolactin cells. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 46: 101-8. PMID 9405499 DOI: 10.1177/002215549804600113 |
0.346 |
|
| 2000 |
HOSPITAL V, CHESNEAU V, BALOGH A, JOULIE C, SEIDAH NG, COHEN P, PRAT A. N-arginine dibasic convertase (nardilysin) isoforms are soluble dibasic-specific metalloendopeptidases that localize in the cytoplasm and at the cell surface Biochemical Journal. 349: 587-597. DOI: 10.1042/Bj3490587 |
0.348 |
|
| 2000 |
LISSITZKY J, LUIS J, MUNZER JS, BENJANNET S, PARAT F, CHRÉTIEN M, MARVALDI J, SEIDAH NG. Endoproteolytic processing of integrin pro-α subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7 Biochemical Journal. 346: 133-138. DOI: 10.1042/Bj3460133 |
0.333 |
|
| 2000 |
Lopez-Perez E, Seidah N. PC7 contributes to the processing of the Alzheimer's βamyloid precursor protein in human cells Neurobiology of Aging. 21: 96-97. DOI: 10.1016/S0197-4580(00)82657-3 |
0.301 |
|
| 1999 |
Jin L, Kulig E, Qian X, Scheithauer BW, Young WF, Davis DH, Seidah NG, Chretien M, Lloyd RV. Distribution and regulation of proconvertases PC1 and PC2 in human pituitary adenomas. Pituitary. 1: 187-95. PMID 11081197 DOI: 10.1023/A:1009909232243 |
0.348 |
|
| 1999 |
Zhong M, Munzer JS, Basak A, Benjannet S, Mowla SJ, Decroly E, Chrétien M, Seidah NG. The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity. The Journal of Biological Chemistry. 274: 33913-20. PMID 10567353 DOI: 10.1074/Jbc.274.48.33913 |
0.349 |
|
| 1999 |
Canaff L, Bennett HP, Hou Y, Seidah NG, Hendy GN. Proparathyroid hormone processing by the proprotein convertase-7: comparison with furin and assessment of modulation of parathyroid convertase messenger ribonucleic acid levels by calcium and 1,25-dihydroxyvitamin D3. Endocrinology. 140: 3633-42. PMID 10433221 DOI: 10.1210/Endo.140.8.6882 |
0.324 |
|
| 1999 |
Villeneuve P, Seidah NG, Beaudet A. Immunohistochemical distribution of the prohormone convertase PC5-A in rat brain. Neuroscience. 92: 641-54. PMID 10408612 DOI: 10.1016/S0306-4522(98)00763-5 |
0.301 |
|
| 1999 |
Rovère C, Luis J, Lissitzky JC, Basak A, Marvaldi J, Chrétien M, Seidah NG. The RGD motif and the C-terminal segment of proprotein convertase 1 are critical for its cellular trafficking but not for its intracellular binding to integrin alpha5beta1. The Journal of Biological Chemistry. 274: 12461-7. PMID 10212221 DOI: 10.1074/Jbc.274.18.12461 |
0.372 |
|
| 1999 |
Gangnon F, Danger JM, Jegou S, Vieau D, Seidah NG, Vaudry H. Molecular cloning, characterization of cDNA, and distribution of mRNA encoding the frog prohormone convertase PC1. The Journal of Comparative Neurology. 405: 160-72. PMID 10023807 DOI: 10.1002/(Sici)1096-9861(19990308)405:2<160::Aid-Cne2>3.0.Co;2-Y |
0.356 |
|
| 1999 |
Seidah NG, Mowla SJ, Hamelin J, Mamarbachi AM, Benjannet S, Touré BB, Basak A, Munzer JS, Marcinkiewicz J, Zhong M, Barale JC, Lazure C, Murphy RA, Chrétien M, Marcinkiewicz M. Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization. Proceedings of the National Academy of Sciences of the United States of America. 96: 1321-6. PMID 9990022 DOI: 10.1073/Pnas.96.4.1321 |
0.345 |
|
| 1999 |
Boudreault A, Gauthier D, Rondeau N, Savaria D, Seidah NG, Chrétien M, Lazure C. Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells. Protein Expression and Purification. 14: 353-66. PMID 9882569 DOI: 10.1006/Prep.1998.0964 |
0.312 |
|
| 1999 |
BASAK A, TOURÉ BB, LAZURE C, MBIKAY M, CHRÉTIEN M, SEIDAH NG. Enzymic characterization in vitro of recombinant proprotein convertase PC4 Biochemical Journal. 343: 29-37. DOI: 10.1042/Bj3430029 |
0.349 |
|
| 1999 |
BASAK A, COOPER S, ROBERGE AG, BANIK UK, CHRÉTIEN M, SEIDAH NG. Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters Biochemical Journal. 338: 107-113. DOI: 10.1042/Bj3380107 |
0.306 |
|
| 1998 |
Jarriault S, Le Bail O, Hirsinger E, Pourquie O, Logeat F, Strong CF, Brou C, Seidah NG, Israel A. Delta-1 activation of Notch-1 signaling results in HES-1 transactivation Molecular and Cellular Biology. 18: 7423-7431. PMID 9819428 DOI: 10.1128/Mcb.18.12.7423 |
0.32 |
|
| 1998 |
Girardin SE, Benjannet S, Barale JC, Chrétien M, Seidah NG. The LIM homeobox protein mLIM3/Lhx3 induces expression of the prolactin gene by a Pit-1/GHF-1-independent pathway in corticotroph AtT20 cells Febs Letters. 431: 333-338. PMID 9714537 DOI: 10.1016/S0014-5793(98)00787-X |
0.333 |
|
| 1998 |
Logeat F, Bessia C, Brou C, LeBail O, Jarriault S, Seidah NG, Israël A. The Notch1 receptor is cleaved constitutively by a furin-like convertase Proceedings of the National Academy of Sciences of the United States of America. 95: 8108-8112. PMID 9653148 DOI: 10.1073/Pnas.95.14.8108 |
0.333 |
|
| 1998 |
Benjannet S, Mamarbachi AM, Hamelin J, Savaria D, Munzer JS, Chrétien M, Seidah NG. Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity. Febs Letters. 428: 37-42. PMID 9645470 DOI: 10.1016/S0014-5793(98)00480-3 |
0.376 |
|
| 1998 |
Lazure C, Gauthier D, Jean F, Boudreault A, Seidah NG, Bennett HP, Hendy GN. In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor. The Journal of Biological Chemistry. 273: 8572-80. PMID 9535830 DOI: 10.1074/Jbc.273.15.8572 |
0.318 |
|
| 1998 |
Laslop A, Weiss C, Savaria D, Eiter C, Tooze SA, Seidah NG, Winkler H. Proteolytic processing of chromogranin B and secretogranin II by prohormone convertases. Journal of Neurochemistry. 70: 374-83. PMID 9422384 DOI: 10.1046/J.1471-4159.1998.70010374.X |
0.325 |
|
| 1997 |
Seidah NG, Chrétien M. Eukaryotic protein processing: endoproteolysis of precursor proteins. Current Opinion in Biotechnology. 8: 602-7. PMID 9353231 DOI: 10.1016/S0958-1669(97)80036-5 |
0.362 |
|
| 1997 |
Lusson J, Benjannet S, Hamelin J, Savaria D, Chrétien M, Seidah NG. The integrity of the RRGDL sequence of the proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking. The Biochemical Journal. 737-44. PMID 9307023 DOI: 10.1042/Bj3260737 |
0.371 |
|
| 1997 |
Basak A, Ernst B, Brewer D, Seidah NG, Munzer JS, Lazure C, Lajoie GA. Histidine-rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1 Journal of Peptide Research. 49: 596-603. PMID 9266488 DOI: 10.1111/J.1399-3011.1997.Tb01168.X |
0.3 |
|
| 1997 |
Sánchez E, Charli JL, Morales C, Corkidi G, Seidah NG, Joseph-Bravo P, Uribe RM. Expression of the proprotein convertases PC1 and PC2 mRNAs in thyrotropin releasing hormone neurons of the rat paraventricular nucleus of hypothalamus. Brain Research. 761: 77-86. PMID 9247068 DOI: 10.1016/S0006-8993(97)00280-1 |
0.311 |
|
| 1997 |
Munzer JS, Basak A, Zhong M, Mamarbachi A, Hamelin J, Savaria D, Lazure C, Hendy GN, Benjannet S, Chrétien M, Seidah NG. In vitro characterization of the novel proprotein convertase PC7. The Journal of Biological Chemistry. 272: 19672-81. PMID 9242622 DOI: 10.1074/Jbc.272.32.19672 |
0.371 |
|
| 1997 |
Basak A, Boudreault A, Chen A, Chrétien M, Seidah NG, Lazure C. Application of the multiple antigenic peptides (MAP) strategy to the production of prohormone convertases antibodies: synthesis, characterization and use of 8-branched immunogenic peptides. Journal of Peptide Science : An Official Publication of the European Peptide Society. 1: 385-95. PMID 9223018 DOI: 10.1002/Psc.310010606 |
0.31 |
|
| 1997 |
Hörsch D, Day R, Seidah NG, Weihe E, Schäfer MK. Immunohistochemical localization of the pro-peptide processing enzymes PC1/PC3 and PC2 in the human anal canal. Peptides. 18: 755-60. PMID 9213372 DOI: 10.1016/S0196-9781(96)00029-0 |
0.333 |
|
| 1997 |
Mbikay M, Tadros H, Ishida N, Lerner CP, De Lamirande E, Chen A, El-Alfy M, Clermont Y, Seidah NG, Chrétien M, Gagnon C, Simpson EM. Impaired fertility in mice deficient for the testicular germ-cell protease PC4. Proceedings of the National Academy of Sciences of the United States of America. 94: 6842-6. PMID 9192653 DOI: 10.1073/Pnas.94.13.6842 |
0.307 |
|
| 1997 |
Jutras I, Seidah NG, Reudelhuber TL, Brechler V. Two activation states of the prohormone convertase PC1 in the secretory pathway. The Journal of Biological Chemistry. 272: 15184-8. PMID 9182540 DOI: 10.1074/Jbc.272.24.15184 |
0.365 |
|
| 1997 |
Zheng M, Seidah NG, Pintar JE. The developmental expression in the rat CNS and peripheral tissues of proteases PC5 and PACE4 mRNAs: comparison with other proprotein processing enzymes. Developmental Biology. 181: 268-83. PMID 9013936 DOI: 10.1006/Dbio.1996.8402 |
0.321 |
|
| 1997 |
De Bie I, Marcinkiewicz M, Malide D, Lazure C, Nakayama K, Bendayan M, Seidah NG. The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments. The Journal of Cell Biology. 135: 1261-75. PMID 8947550 DOI: 10.1083/Jcb.135.5.1261 |
0.375 |
|
| 1997 |
Zhong M, Benjannet S, Lazure C, Munzer S, Seidah NG. Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform. Febs Letters. 396: 31-6. PMID 8906861 DOI: 10.1016/0014-5793(96)01059-9 |
0.331 |
|
| 1997 |
Seidah N. Mammalian pro-hormone convertase Biofutur. 1997: 48. DOI: 10.1016/S0294-3506(99)80359-7 |
0.319 |
|
| 1996 |
Mercure C, Jutras I, Day R, Seidah NG, Reudelhuber TL. Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex. Hypertension. 28: 840-6. PMID 8901832 DOI: 10.1161/01.Hyp.28.5.840 |
0.348 |
|
| 1996 |
Voigt P, Ma YJ, Gonzalez D, Fahrenbach WH, Wetsel WC, Berg-von der Emde K, Hill DF, Taylor KG, Costa ME, Seidah NG, Ojeda SR. Neural and glial-mediated effects of growth factors acting via tyrosine kinase receptors on luteinizing hormone-releasing hormone neurons. Endocrinology. 137: 2593-605. PMID 8641214 DOI: 10.1210/Endo.137.6.8641214 |
0.317 |
|
| 1996 |
Seidah NG, Hamelin J, Mamarbachi M, Dong W, Tardos H, Mbikay M, Chretien M, Day R. cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases. Proceedings of the National Academy of Sciences of the United States of America. 93: 3388-93. PMID 8622945 DOI: 10.1073/Pnas.93.8.3388 |
0.343 |
|
| 1996 |
Campan M, Yoshizumi M, Seidah NG, Lee ME, Bianchi C, Haber E. Increased proteolytic processing of protein tyrosine phosphatase mu in confluent vascular endothelial cells: the role of PC5, a member of the subtilisin family. Biochemistry. 35: 3797-802. PMID 8620001 DOI: 10.1021/Bi952552D |
0.376 |
|
| 1996 |
Seidah NG, Benjannet S, Pareek S, Savaria D, Hamelin J, Goulet B, Laliberte J, Lazure C, Chrétien M, Murphy RA. Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases. The Biochemical Journal. 314: 951-60. PMID 8615794 DOI: 10.1042/Bj3140951 |
0.361 |
|
| 1996 |
Seidah NG, Benjannet S, Pareek S, Chrétien M, Murphy RA. Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases. Febs Letters. 379: 247-50. PMID 8603699 DOI: 10.1016/0014-5793(95)01520-5 |
0.339 |
|
| 1995 |
Hoflehner J, Eder U, Laslop A, Seidah NG, Fischer-Colbrie R, Winkler H. Processing of secretogranin II by prohormone convertases: importance of PC1 in generation of secretoneurin. Febs Letters. 360: 294-8. PMID 7883050 DOI: 10.1016/0014-5793(95)00127-U |
0.307 |
|
| 1995 |
Day R, Benjannet S, Matsuuchi L, Kelly RB, Marcinkiewicz M, Chrétien M, Seidah NG. Maintained PC1 and PC2 expression in the AtT-20 variant cell line 6T3 lacking regulated secretion and POMC: restored POMC expression and regulated secretion after cAMP treatment. Dna and Cell Biology. 14: 175-88. PMID 7865135 DOI: 10.1089/Dna.1995.14.175 |
0.308 |
|
| 1995 |
Seidah NG, Chrétien M. Pro-protein convertases of subtilisin/kexin family. Methods in Enzymology. 244: 175-88. PMID 7845206 DOI: 10.1016/0076-6879(94)44015-8 |
0.351 |
|
| 1995 |
De Bie I, Savaria D, Roebroek AJ, Day R, Lazure C, Van de Ven WJ, Seidah NG. Processing specificity and biosynthesis of the Drosophila melanogaster convertases dfurin1, dfurin1-CRR, dfurin1-X, and dfurin2. The Journal of Biological Chemistry. 270: 1020-8. PMID 7836354 DOI: 10.1074/Jbc.270.3.1020 |
0.382 |
|
| 1995 |
Malide D, Seidah NG, Chrétien M, Bendayan M. Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 43: 11-9. PMID 7822759 DOI: 10.1177/43.1.7822759 |
0.351 |
|
| 1995 |
Seidah NG, Chrétien M, Day R. The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions. Biochimie. 76: 197-209. PMID 7819324 DOI: 10.1016/0300-9084(94)90147-3 |
0.354 |
|
| 1995 |
Seidah NG, Barale JC, Marcinkiewicz M, Mattei MG, Day R, Chrétien M. The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary. Dna and Cell Biology. 13: 1163-80. PMID 7811383 DOI: 10.1089/Dna.1994.13.1163 |
0.322 |
|
| 1995 |
Beaubien G, Schäfer MKH, Weihe E, Dong W, Chrétien M, Seidah NG, Day R. The distinct gene expression of the pro-hormone convertases in the rat heart suggests potential substrates Cell and Tissue Research. 279: 539-549. PMID 7736551 DOI: 10.1007/Bf00318166 |
0.303 |
|
| 1995 |
Benjannet S, Savaria D, Chrétien M, Seidah NG. 7B2 is a specific intracellular binding protein of the prohormone convertase PC2. Journal of Neurochemistry. 64: 2303-11. PMID 7722516 DOI: 10.1046/J.1471-4159.1995.64052303.X |
0.319 |
|
| 1995 |
Hendy GN, Bennett HP, Gibbs BF, Lazure C, Day R, Seidah NG. Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin. A mass spectrometric study. The Journal of Biological Chemistry. 270: 9517-25. PMID 7721880 DOI: 10.1074/Jbc.270.16.9517 |
0.373 |
|
| 1995 |
Brakch N, Galanopoulou AS, Patel YC, Boileau G, Seidah NG. Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways Febs Letters. 362: 143-146. PMID 7720860 DOI: 10.1016/0014-5793(95)00229-3 |
0.312 |
|
| 1995 |
Jean F, Boudreault A, Basak A, Seidah NG, Lazure C. Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and human furin and designing a potent irreversible inhibitor. The Journal of Biological Chemistry. 270: 19225-31. PMID 7642593 DOI: 10.1074/Jbc.270.33.19225 |
0.31 |
|
| 1995 |
Brakch N, Dettin M, Scarinci C, Seidah NG, Di Bello C. Structural investigation and kinetic characterization of potential cleavage sites of HIV GP160 by human furin and PC1. Biochemical and Biophysical Research Communications. 213: 356-61. PMID 7639757 DOI: 10.1006/Bbrc.1995.2137 |
0.316 |
|
| 1995 |
Bendayan M, Malide D, Ziv E, Levy E, Ben-Sasson R, Kalman R, Bar-On H, Chrétien M, Seidah N. Immunocytochemical investigation of insulin secretion by pancreatic beta-cells in control and diabetic Psammomys obesus. Journal of Histochemistry and Cytochemistry. 43: 771-784. PMID 7622840 DOI: 10.1177/43.8.7622840 |
0.305 |
|
| 1995 |
Galanopoulou AS, Seidah NG, Patel YC. Heterologous processing of rat prosomatostatin to somatostatin-14 by PC2: requirement for secretory cell but not the secretion granule. The Biochemical Journal. 111-8. PMID 7575441 DOI: 10.1042/Bj3110111 |
0.344 |
|
| 1994 |
Dupuy A, Lindberg I, Zhou Y, Akil H, Lazure C, Chrétien M, Seidah NG, Day R. Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms. Cleavage at a single arginine residue. Febs Letters. 337: 60-5. PMID 8276115 DOI: 10.1016/0014-5793(94)80630-6 |
0.329 |
|
| 1994 |
Mbikay M, Raffin-Sanson ML, Tadros H, Sirois F, Seidah NG, Chretien M. Structure of the gene for the testis-specific proprotein convertase 4 and of its alternate messenger RNA isoforms Genomics. 20: 231-237. PMID 8020970 DOI: 10.1006/Geno.1994.1158 |
0.302 |
|
| 1994 |
Reudelhuber TL, Ramla D, Chiu L, Mercure C, Seidah NG. Proteolytic processing of human prorenin in renal and non-renal tissues Kidney International. 46: 1522-1524. PMID 7699995 DOI: 10.1038/Ki.1994.435 |
0.314 |
|
| 1993 |
Schäfer MK, Day R, Cullinan WE, Chrétien M, Seidah NG, Watson SJ. Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 1258-79. PMID 8441010 DOI: 10.1523/Jneurosci.13-03-01258.1993 |
0.335 |
|
| 1993 |
Benjannet S, Rondeau N, Paquet L, Boudreault A, Lazure C, Chrétien M, Seidah NG. Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2. The Biochemical Journal. 735-43. PMID 8397508 DOI: 10.1042/Bj2940735 |
0.338 |
|
| 1993 |
Marcinkiewicz M, Day R, Seidah NG, Chrétien M. Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin. Proceedings of the National Academy of Sciences of the United States of America. 90: 4922-6. PMID 8389457 DOI: 10.1073/Pnas.90.11.4922 |
0.311 |
|
| 1993 |
Ouimet T, Mammarbachi A, Cloutier T, Seidah NG, Castellucci VF. cDNA structure and in situ localization of the Aplysia californica pro-hormone convertase PC2 Febs Letters. 330: 343-346. PMID 8375506 DOI: 10.1016/0014-5793(93)80901-6 |
0.341 |
|
| 1993 |
Lusson J, Vieau D, Hamelin J, Day R, Chrétien M, Seidah NG. cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 6691-5. PMID 8341687 DOI: 10.1073/Pnas.90.14.6691 |
0.342 |
|
| 1993 |
Basak A, Yuan XW, Harris R, Seidah NG, Chrétien M. Synthesis of the segment (11-23) located in the first tandem repeat of plasma kallikrein: comparative binding studies of this and another segment (328-343) to high-molecular-mass kininogen. Journal of Chromatography. 615: 251-64. PMID 8335703 DOI: 10.1016/0378-4347(93)80339-6 |
0.311 |
|
| 1993 |
Jean F, Basak A, Rondeau N, Benjannet S, Hendy GN, Seidah NG, Chrétien M, Lazure C. Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells. The Biochemical Journal. 891-900. PMID 8318017 DOI: 10.1042/Bj2920891 |
0.352 |
|
| 1993 |
Lin HL, Day NC, Ueda Y, Martin DK, Dixon JE, Seidah NG, Akil H. Tissue-specific and substrate-specific endoproteolytic cleavage of monkey pro-opiomelanocortin in heterologous endocrine cells: processing at Lys-Lys dibasic pairs. Neuroendocrinology. 58: 94-105. PMID 7903430 DOI: 10.1159/000126518 |
0.304 |
|
| 1993 |
Clark DA, Day R, Seidah N, Moody TW, Cuttitta F, Davis TP. Protease inhibitors suppress in vitro growth of human small cell lung cancer. Peptides. 14: 1021-8. PMID 7506831 DOI: 10.1016/0196-9781(93)90081-Q |
0.302 |
|
| 1992 |
Lazure C, Benjannet S, Seidah NG, Chrétien M. Processed forms of neuroendocrine proteins 7B2 and secretogranin II are found in porcine pituitary extracts. International Journal of Peptide and Protein Research. 38: 392-400. PMID 1797712 DOI: 10.1111/J.1399-3011.1991.Tb01519.X |
0.307 |
|
| 1992 |
Paquet L, Rondeau N, Seidah NG, Lazure C, Chrétien M, Mbikay M. Immunological identification and sequence characterization of a peptide derived from the processing of neuroendocrine protein 7B2. Febs Letters. 294: 23-6. PMID 1743287 DOI: 10.1016/0014-5793(91)81334-5 |
0.314 |
|
| 1992 |
Seidah NG, Day R, Hamelin J, Gaspar A, Collard MW, Chrétien M. Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase. Molecular Endocrinology (Baltimore, Md.). 6: 1559-70. PMID 1448111 DOI: 10.1210/Mend.6.10.1448111 |
0.351 |
|
| 1992 |
Gabreëls BA, Sonnemans MA, Seidah NG, Chrétien M, van Leeuwen FW. Dynamics of 7B2 and galanin expression in solitary magnocellular hypothalamic vasopressin neurons of the homozygous Brattleboro rat. Brain Research. 585: 275-82. PMID 1380870 DOI: 10.1016/0006-8993(92)91218-4 |
0.308 |
|
| 1992 |
Day R, Schafer MK, Watson SJ, Chrétien M, Seidah NG. Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary. Molecular Endocrinology (Baltimore, Md.). 6: 485-97. PMID 1316544 DOI: 10.1210/Mend.6.3.1316544 |
0.316 |
|
| 1991 |
Benjannet S, Rondeau N, Day R, Chrétien M, Seidah NG. PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proceedings of the National Academy of Sciences of the United States of America. 88: 3564-8. PMID 2023902 DOI: 10.1073/Pnas.88.9.3564 |
0.339 |
|
| 1991 |
Seidah NG, Marcinkiewicz M, Benjannet S, Gaspar L, Beaubien G, Mattei MG, Lazure C, Mbikay M, Chrétien M. Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. Molecular Endocrinology (Baltimore, Md.). 5: 111-22. PMID 2017186 DOI: 10.1210/Mend-5-1-111 |
0.322 |
|
| 1991 |
Paquet L, Lazure C, Seidah NG, Chrétien M, Mbikay M. The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man. Biochemical and Biophysical Research Communications. 174: 156-62. PMID 1989596 DOI: 10.1016/0006-291X(91)90499-W |
0.304 |
|
| 1991 |
Ladenheim RG, Seidah NG, Rougeon F. N-linked glycosylation affects the processing of mouse submaxillary gland prorenin in transfected AtT20 cells. European Journal of Biochemistry. 198: 535-40. PMID 1904027 DOI: 10.1111/J.1432-1033.1991.Tb16047.X |
0.341 |
|
| 1991 |
Sawyer N, Rondeau N, Chrétien M, Seidah NG. Expression and sorting of rat plasma kallikrein in POMC-producing AtT-20 cells Dna and Cell Biology. 10: 259-269. PMID 1851425 DOI: 10.1089/Dna.1991.10.259 |
0.348 |
|
| 1990 |
Leduc R, Hendy GN, Seidah NG, Chrétien M, Lazure C. Fragmentation of bovine chromogranin A by plasma kallikrein. Life Sciences. 46: 1427-33. PMID 2345487 DOI: 10.1016/0024-3205(90)90458-4 |
0.342 |
|
| 1990 |
Seidah NG, Sawyer N, Hamelin J, Mion P, Beaubien G, Brachpapa L, Rochemont J, Mbikay M, Chretien M. Mouse plasma kallikrein: cDNA structure, enzyme characterization, and comparison of protein and mRNA levels among species Dna and Cell Biology. 9: 737-748. PMID 2264928 DOI: 10.1089/Dna.1990.9.737 |
0.314 |
|
| 1990 |
Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M, Chrétien M. cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. Dna and Cell Biology. 9: 415-24. PMID 2169760 DOI: 10.1089/Dna.1990.9.415 |
0.314 |
|
| 1989 |
Linard CG, Mbikay M, Benjannet S, Lazure C, Seidah NG, Chrétien M. Correct processing and secretion of a human prostatic secretory protein (PSP94) in Escherichia coli. Gene. 73: 479-87. PMID 3072267 DOI: 10.1016/0378-1119(88)90512-4 |
0.316 |
|
| 1989 |
Paquin J, Benjannet S, Sawyer N, Lazure C, Chrétien M, Seidah NG. Rat plasma kallikrein: purification, NH2-terminal sequencing and development of a specific radioimmunoassay Biochimica Et Biophysica Acta (Bba)/Protein Structure and Molecular. 999: 103-110. PMID 2597701 DOI: 10.1016/0167-4838(89)90206-9 |
0.31 |
|
| 1989 |
Chrétien M, Sikstrom RA, Lazure C, Mbikay M, Seidah NG. Functional diversity of bioactive peptides in the nervous system itself: “How the brain may understand” Bioscience Reports. 9: 693-700. PMID 2575404 DOI: 10.1007/Bf01114807 |
0.316 |
|
| 1989 |
Mbikay M, Grant SG, Sirois F, Tadros H, Skowronski J, Lazure C, Seidah NG, Hanahan D, Chrétien M. cDNA sequence of neuroendocrine protein 7B2 expressed in beta cell tumors of transgenic mice. International Journal of Peptide and Protein Research. 33: 39-45. PMID 2542174 DOI: 10.1111/J.1399-3011.1989.Tb00681.X |
0.323 |
|
| 1988 |
Benjannet S, Leduc R, Adrouche N, Falgueyret JP, Marcinkiewicz M, Seidah NG, Mbikay M, Lazure C, Chretien M. Chromogranin B (secretogranin I), a putative precursor of two novel pituitary peptides through processing at paired basic residues. Febs Letters. 224: 142-8. PMID 3678488 DOI: 10.1016/0014-5793(87)80438-6 |
0.309 |
|
| 1988 |
Seidah NG, Paquin J, Hamelin J, Benjannet S, Chretien M. Structural and immunological homology of human and porcine pituitary and plasma IRCM-serine protease 1 to plasma kallikrein: marked selectivity for pairs of basic residues suggests a widespread role in pro-hormone and pro-enzyme processing Biochimie. 70: 33-46. PMID 2969754 DOI: 10.1016/0300-9084(88)90156-3 |
0.339 |
|
| 1987 |
Dubé JY, Frenette G, Paquin R, Chapdelaine P, Tremblay J, Tremblay RR, Lazure C, Seidah N, Chrétien M. Isolation from human seminal plasma of an abundant 16-kDa protein originating from the prostate, its identification with a 94-residue peptide originally described as beta-inhibin. Journal of Andrology. 8: 182-9. PMID 3610813 DOI: 10.1002/J.1939-4640.1987.Tb02429.X |
0.302 |
|
| 1987 |
Lazure C, Leduc R, Seidah NG, Thibault G, Genest J, Chrétien M. The complete amino acid sequence of rat submaxillary gland tonin does contain the aspartic acid at the active site: confirmation by protein sequence analysis. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 65: 321-37. PMID 3038148 DOI: 10.1139/O87-042 |
0.309 |
|
| 1987 |
Seidah NG, Hendy GN, Hamelin J, Paquin J, Lazure C, Metters KM, Rossier J, Chrétien M. Chromogranin A can act as a reversible processing enzyme inhibitor. Evidence from the inhibition of the IRCM-serine protease 1 cleavage of pro-enkephalin and ACTH at pairs of basic amino acids. Febs Letters. 211: 144-50. PMID 3026846 DOI: 10.1016/0014-5793(87)81425-4 |
0.336 |
|
| 1987 |
Ong H, Lazure C, Nguyen TT, McNicoll N, Seidah N, Chrétien M, De Léan A. Bovine adrenal chromaffin granules are a site of synthesis of atrial natriuretic factor. Biochemical and Biophysical Research Communications. 147: 957-63. PMID 2959287 DOI: 10.1016/S0006-291X(87)80163-8 |
0.324 |
|
| 1987 |
Thibault G, Garcia R, Gutkowska J, Bilodeau J, Lazure C, Seidah NG, Chrétien M, Genest J, Cantin M. The propeptide Asn1-Tyr126 is the storage form of rat atrial natriuretic factor. The Biochemical Journal. 241: 265-72. PMID 2952112 DOI: 10.1042/Bj2410265 |
0.342 |
|
| 1986 |
Burbach JP, Seidah NG, Chrétien M. Isolation and primary structure of novel neurointermediate pituitary peptides derived from the C-terminal of the rat vasopressin-neurophysin precursor (propressophysin). European Journal of Biochemistry. 156: 137-42. PMID 3956504 DOI: 10.1111/J.1432-1033.1986.Tb09558.X |
0.304 |
|
| 1986 |
Bennett HP, Seidah NG, Benjannet S, Solomon S, Chrétien M. Reinvestigation of the disulfide bridge arrangement in human pro-opiomelanocortin N-terminal segment (hNT 1-76). International Journal of Peptide and Protein Research. 27: 306-13. PMID 3519485 DOI: 10.1111/J.1399-3011.1986.Tb01825.X |
0.307 |
|
| 1986 |
Seidah NG, Cromlish JA, Hamelin J, Thibault G, Chrétien M. Homologous IRCM-Serine Protease 1 from pituitary, heart atrium and ventricle: A common pro-hormone maturation enzyme? Bioscience Reports. 6: 835-844. PMID 3028526 DOI: 10.1007/Bf01117107 |
0.314 |
|
| 1986 |
Ong H, McNicoll N, Lazure C, Seidah N, Chrétien M, Cantin M, De Léan A. Purification and sequence determination of bovine atrial natriuretic factor. Life Sciences. 38: 1309-15. PMID 3007908 DOI: 10.1016/0024-3205(86)90425-X |
0.315 |
|
| 1985 |
Benjannet S, Leduc R, Lazure C, Seidah NG, Marcinkiewicz M, Chrétien M. GAWK, a novel human pituitary polypeptide: isolation, immunocytochemical localization and complete amino acid sequence. Biochemical and Biophysical Research Communications. 126: 602-9. PMID 3970711 DOI: 10.1016/0006-291X(85)90648-5 |
0.323 |
|
| 1985 |
Thibault G, Lazure C, Schiffrin EL, Gutkowska J, Chartier L, Garcia R, Seidah NG, Chrétien M, Genest J, Cantin M. Identification of a biologically active circulating form of rat atrial natriuretic factor. Biochemical and Biophysical Research Communications. 130: 981-6. PMID 3161512 DOI: 10.1016/0006-291X(85)91711-5 |
0.312 |
|
| 1985 |
Gutkowska J, Lazure C, Racz K, Thibault G, Garcia R, Seidah NG, Chrétien M, Genest J, Cantin M. ANF (Arg 101--Tyr 126) is the peptide secreted by rat atrial cardiocytes in culture. Biochemical and Biophysical Research Communications. 130: 1217-25. PMID 3161510 DOI: 10.1016/0006-291X(85)91744-9 |
0.312 |
|
| 1985 |
De Léan A, Thibault G, Seidah NG, Lazure C, Gutkowska J, Chrétien M, Genest J, Cantin M. Structure-activity relationships of atrial natriuretic factor (ANF). III. Correlation of receptor affinity with relative potency on aldosterone production in zona glomerulosa cells. Biochemical and Biophysical Research Communications. 132: 360-7. PMID 2998358 DOI: 10.1016/0006-291X(85)91030-7 |
0.304 |
|
| 1984 |
Seidah NG, Ramasharma K, Sairam MR, Chrétien M. Partial amino acid sequence of a human seminal plasma peptide with inhibin-like activity. Febs Letters. 167: 98-102. PMID 6698208 DOI: 10.1016/0014-5793(84)80840-6 |
0.323 |
|
| 1984 |
Seidah NG, Arbatti NJ, Rochemont J, Sheth AR, Chrétien M. Complete amino acid sequence of human seminal plasma beta-inhibin. Prediction of post Gln-Arg cleavage as a maturation site. Febs Letters. 175: 349-55. PMID 6434350 DOI: 10.1016/0014-5793(84)80766-8 |
0.334 |
|
| 1984 |
Lazure C, Leduc R, Seidah NG, Thibault G, Genest J, Chrétien M. Amino acid sequence of rat submaxillary tonin reveals similarities to serine proteases. Nature. 307: 555-558. PMID 6320014 DOI: 10.1038/307555A0 |
0.318 |
|
| 1984 |
Seidah NG, Lazure C, Chrétien M, Thibault G, Garcia R, Cantin M, Genest J, Nutt RF, Brady SF, Lyle TA. Amino acid sequence of homologous rat atrial peptides: natriuretic activity of native and synthetic forms. Proceedings of the National Academy of Sciences of the United States of America. 81: 2640-4. PMID 6232612 DOI: 10.1073/Pnas.81.9.2640 |
0.301 |
|
| 1984 |
Ramasharma K, Sairam MR, Seidah NG, Chrétien M, Manjunath P, Schiller PW, Yamashiro D, Choh Had LI. Isolation, structure, and synthesis of a human seminal plasma peptide with inhibin-like activity Science. 223: 1202. DOI: 10.1126/Science.6422553 |
0.328 |
|
| 1983 |
Seidah NG, Pélaprat D, Lazure C, Chrétien M. Enzymatic cleavage of pro-opiomelanocortin by anterior pituitary granules. Evidence for a chymotryptic-like enzyme. Febs Letters. 159: 68-74. PMID 6873305 DOI: 10.1016/0014-5793(83)80418-9 |
0.309 |
|
| 1983 |
Hsi KL, Seidah NG, De Serres G, Chrétien M. Isolation and NH2-terminal sequence of a novel porcine anterior pituitary polypeptide. Homology to proinsulin, secretin and Rous sarcoma virus transforming protein TVFV60. Febs Letters. 147: 261-6. PMID 6816630 DOI: 10.1016/0014-5793(82)81055-7 |
0.306 |
|
| 1983 |
Seidah NG, Hsi KL, De Serres G, Rochemont J, Hamelin J, Antakly T, Cantin M, Chrétien M. Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus. Archives of Biochemistry and Biophysics. 225: 525-34. PMID 6625600 DOI: 10.1016/0003-9861(83)90063-2 |
0.328 |
|
| 1982 |
Boileau G, Larivière N, Hsi KL, Seidah NG, Chrétien M. Characterization of multiple forms of porcine anterior pituitary proopiomelanocortin amino-terminal glycopeptide Biochemistry. 21: 5341-5346. PMID 7171563 DOI: 10.1021/Bi00264A034 |
0.304 |
|
| 1982 |
Sairam MR, Seidah NG, Chrétien M. Primary structure of the ovine pituitary follitropin beta-subunit. The Biochemical Journal. 197: 541-52. PMID 6798969 DOI: 10.1042/Bj1970541 |
0.304 |
|
| 1982 |
Seidah NG, Rochemont J, Hamelin J, Benjannet S, Chrétien M. The missing fragment of the pro-sequence of human pro-opiomelanocortin: sequence and evidence for C-terminal amidation. Biochemical and Biophysical Research Communications. 102: 710-6. PMID 6272808 DOI: 10.1016/S0006-291X(81)80190-8 |
0.312 |
|
| 1982 |
Watson SJ, Seidah NG, Chrétien M. The carboxy terminus of the precursor to vasopressin and neurophysin: immunocytochemistry in rat brain. Science (New York, N.Y.). 217: 853-5. PMID 6125034 DOI: 10.1126/Science.6125034 |
0.301 |
|
| 1981 |
Crine P, Seidah NG, Routhier R, Gossard F, Chrétien M. Processing of two forms of the common precursor to alpha-melanotropin and beta-endorphin in the rat pars intermedia. Evidence for and partial characterization of new pituitary peptides. European Journal of Biochemistry. 110: 387-96. PMID 7439167 DOI: 10.1111/J.1432-1033.1980.Tb04879.X |
0.304 |
|
| 1981 |
Seidah NG, Benjannet S, Chrétien M. The complete sequence of a novel human pituitary glycopeptide homologous to pig posterior pituitary glycopeptide. Biochemical and Biophysical Research Communications. 100: 901-7. PMID 7271787 DOI: 10.1016/S0006-291X(81)80258-6 |
0.316 |
|
| 1981 |
Pelletier G, Leclerc R, Benjannet S, Seidah NG, Chrétien M. Immunohistochemical localization of gamma-melanocyte-stimulating hormone in the rat pituitary gland. Regulatory Peptides. 2: 81-9. PMID 7019988 DOI: 10.1016/0167-0115(81)90002-1 |
0.301 |
|
| 1981 |
Lazure C, Seidah NG, Thibault G, Boucher R, Genest J, Chrétien M. Sequence homologies between tonin, nerve growth factor gamma-subunit, epidermal growth factor-binding protein and serine proteases. Nature. 292: 383-384. PMID 6265796 DOI: 10.1038/292383A0 |
0.302 |
|
| 1981 |
Policastro P, Phillips M, Oates E, Herbert E, Roberts JL, Seidah N, Chrétien M. Evidence for a signal sequence at the N terminus of the common precursor to adrenocorticothrophin and beta-lipotropin in mouse pituitary cells. European Journal of Biochemistry / Febs. 116: 255-9. PMID 6166472 DOI: 10.1111/J.1432-1033.1981.Tb05327.X |
0.304 |
|
| 1980 |
Seidah NG, Benjannet S, Routhier R, De Serres G, Rochemont J, Lis M, Chrétien M. Purification and characterization of the N-terminal fragment of pro-opiomelanocortin from human pituitaries: homology to the bovine sequence. Biochemical and Biophysical Research Communications. 95: 1417-24. PMID 7417326 DOI: 10.1016/S0006-291X(80)80055-6 |
0.315 |
|
| 1980 |
Benjannet S, Seidah NG, Routhier R, Chrétien M. A novel human pituitary peptide containing the γ-MSH sequence Nature. 285: 415-416. PMID 7189826 DOI: 10.1038/285415A0 |
0.322 |
|
| 1980 |
Gossard F, Seidah NG, Crine P, Routhier R, Chrétien M. Partial N-terminal amino acid sequence of pro-opio-melanocortin (ACTH/beta-LPH precursor) from rat pars intermedia. Biochemical and Biophysical Research Communications. 92: 1042-51. PMID 6244815 DOI: 10.1016/0006-291X(80)90807-4 |
0.309 |
|
| 1979 |
Scherrer H, Seidah NG, Renjannet S, Crine P, Lis M, Chrétien M. Biosynthesis of a ubiquitin-related peptide in rat brain and in human and mouse pituitary tumors. Biochemical and Biophysical Research Communications. 84: 874-85. PMID 728156 DOI: 10.1016/0006-291X(78)91665-0 |
0.317 |
|
| 1979 |
Seidah NG, Routhier R, Caron M, Chrétien M, Demassieux S, Boucher R, Genest J. N-Terminal amino acid sequence of rat tonin: homology with serine proteases. Canadian Journal of Biochemistry. 56: 920-5. PMID 215293 DOI: 10.1139/O78-142 |
0.302 |
|
| 1978 |
Seidah NG, Crine P, Benjannet S, Scherrer H, Chrétien M. Isolation and partial characterization of a biosynthetic N-terminal methionyl peptide of bovine pars intermedia: relationship to ubiquitin. Biochemical and Biophysical Research Communications. 80: 600-8. PMID 629794 DOI: 10.1016/0006-291X(78)91611-X |
0.315 |
|
| 1978 |
Crine P, Benjannet S, Seidah NG, Lis M, Chrétien M. In vitro biosynthesis of beta-endorphin, gamma-lipoprotein, and beta-lipotropin by the pars intermedia of beef pituitary glands. Proceedings of the National Academy of Sciences of the United States of America. 74: 4276-80. PMID 270671 DOI: 10.1073/Pnas.74.10.4276 |
0.303 |
|
| 1976 |
Chrétien M, Gilardeau C, Seidah N, Lis M. Purification and partial chemical characterization of human pituitary lipolytic hormone. Canadian Journal of Biochemistry. 54: 778-82. PMID 183879 DOI: 10.1139/O76-111 |
0.312 |
|
| 1974 |
de Levie R, Seidah NG. Transport of ions of one kind through thin membranes. 3. Current-voltage curves for membrane-soluble ions. The Journal of Membrane Biology. 16: 1-16. PMID 4837993 DOI: 10.1007/BF01872404 |
0.481 |
|
| 1974 |
De Levie R, Seidah N, Larkin D. Tetraphenylborate adsorption onto an artificial ultrathin membrane Journal of Electroanalytical Chemistry and Interfacial Electrochemistry. 49: 153-159. DOI: 10.1016/S0022-0728(74)80358-X |
0.479 |
|
| 1974 |
de Levie R, Seidah NG, Moreira H. Transport of ions of one kind through thin membranes The Journal of Membrane Biology. 16: 17-42. DOI: 10.1007/BF01872405 |
0.482 |
|
| 1972 |
De Levie R, Seidah NG, Moreira H. Transport of ions of one kind through thin membranes. II. Nonequilibrium steady-state behavior. The Journal of Membrane Biology. 10: 171-92. PMID 4669446 DOI: 10.1007/BF01867852 |
0.481 |
|
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