| Year |
Citation |
Score |
| 2024 |
Balakrishnan S, Adolph M, Tsai MS, Akizuki T, Gallagher K, Cortez D, Chazin WJ. Structure of RADX and mechanism for regulation of RAD51 nucleofilaments. Proceedings of the National Academy of Sciences of the United States of America. 121: e2316491121. PMID 38466836 DOI: 10.1073/pnas.2316491121 |
0.373 |
|
| 2023 |
Rua-Fernandez J, Lovejoy CA, Mehta KPM, Paulin KA, Toudji YT, Giansanti C, Eichman BF, Cortez D. Self-reversal facilitates the resolution of HMCES DNA-protein crosslinks in cells. Cell Reports. 42: 113427. PMID 37950866 DOI: 10.1016/j.celrep.2023.113427 |
0.826 |
|
| 2023 |
Balakrishnan S, Adolph M, Tsai MS, Gallagher K, Cortez D, Chazin WJ. Structure of RADX and mechanism for regulation of RAD51 nucleofilaments. Biorxiv : the Preprint Server For Biology. PMID 37786681 DOI: 10.1101/2023.09.19.558089 |
0.306 |
|
| 2023 |
Adolph MB, Garje AS, Balakrishnan S, Morati F, Modesti M, Chazin WJ, Cortez D. CRISPR-dependent Base Editing Screens Identify Separation of Function Mutants of RADX with Altered RAD51 Regulatory Activity. Journal of Molecular Biology. 435: 168236. PMID 37572935 DOI: 10.1016/j.jmb.2023.168236 |
0.56 |
|
| 2023 |
Rua-Fernandez J, Lovejoy CA, Mehta KPM, Paulin KA, Toudji YT, Eichman BF, Cortez D. Self-reversal facilitates the resolution of HMCES-DNA protein crosslinks in cells. Biorxiv : the Preprint Server For Biology. PMID 37398432 DOI: 10.1101/2023.06.14.544844 |
0.823 |
|
| 2023 |
Bhowmick R, Mehta KPM, Lerdrup M, Cortez D. Integrator facilitates RNAPII removal to prevent transcription-replication collisions and genome instability. Molecular Cell. PMID 37295432 DOI: 10.1016/j.molcel.2023.05.015 |
0.412 |
|
| 2023 |
Liu W, Saito Y, Jackson J, Bhowmick R, Kanemaki MT, Vindigni A, Cortez D. RAD51 bypasses the CMG helicase to promote replication fork reversal. Science (New York, N.Y.). 380: 382-387. PMID 37104614 DOI: 10.1126/science.add7328 |
0.526 |
|
| 2023 |
Kavlashvili T, Liu W, Mohamed TM, Cortez D, Dewar JM. Replication fork uncoupling causes nascent strand degradation and fork reversal. Nature Structural & Molecular Biology. PMID 36593312 DOI: 10.1038/s41594-022-00871-y |
0.425 |
|
| 2022 |
Paulin KA, Cortez D, Eichman BF. The SOS response-associated peptidase (SRAP) domain of YedK catalyzes ring opening of abasic sites and reversal of its DNA-protein crosslink. The Journal of Biological Chemistry. 102307. PMID 35934051 DOI: 10.1016/j.jbc.2022.102307 |
0.512 |
|
| 2022 |
Van Ravenstein SX, Mehta KP, Kavlashvili T, Byl JAW, Zhao R, Osheroff N, Cortez D, Dewar JM. Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms. The Embo Journal. e110632. PMID 35578785 DOI: 10.15252/embj.2022110632 |
0.508 |
|
| 2022 |
Mehta KPM, Thada V, Zhao R, Krishnamoorthy A, Leser M, Lindsey Rose K, Cortez D. CHK1 phosphorylates PRIMPOL to promote replication stress tolerance. Science Advances. 8: eabm0314. PMID 35353580 DOI: 10.1126/sciadv.abm0314 |
0.541 |
|
| 2022 |
Mohamed T, Adolph MB, Cortez D. Oligomerization of DNA replication regulatory protein RADX is essential to maintain replication fork stability. The Journal of Biological Chemistry. 298: 101672. PMID 35120927 DOI: 10.1016/j.jbc.2022.101672 |
0.532 |
|
| 2021 |
Krishnamoorthy A, Jackson J, Mohamed T, Adolph M, Vindigni A, Cortez D. RADX prevents genome instability by confining replication fork reversal to stalled forks. Molecular Cell. PMID 34107305 DOI: 10.1016/j.molcel.2021.05.014 |
0.468 |
|
| 2021 |
Adolph MB, Mohamed TM, Balakrishnan S, Xue C, Morati F, Modesti M, Greene EC, Chazin WJ, Cortez D. RADX controls RAD51 filament dynamics to regulate replication fork stability. Molecular Cell. PMID 33453169 DOI: 10.1016/j.molcel.2020.12.036 |
0.511 |
|
| 2020 |
Berti M, Cortez D, Lopes M. The plasticity of DNA replication forks in response to clinically relevant genotoxic stress. Nature Reviews. Molecular Cell Biology. PMID 32612242 DOI: 10.1038/S41580-020-0257-5 |
0.567 |
|
| 2020 |
Mehta KPM, Lovejoy CA, Zhao R, Heintzman DR, Cortez D. HMCES Maintains Replication Fork Progression and Prevents Double-Strand Breaks in Response to APOBEC Deamination and Abasic Site Formation. Cell Reports. 31: 107705. PMID 32492421 DOI: 10.1016/J.Celrep.2020.107705 |
0.814 |
|
| 2020 |
Thompson PS, Cortez D. New insights into abasic site repair and tolerance. Dna Repair. 90: 102866. PMID 32417669 DOI: 10.1016/J.Dnarep.2020.102866 |
0.565 |
|
| 2019 |
Wessel SR, Mohni KN, Luzwick JW, Dungrawala H, Cortez D. Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators. Cell Reports. 28: 3497-3509.e4. PMID 31553917 DOI: 10.1016/J.Celrep.2019.08.051 |
0.846 |
|
| 2019 |
Thompson PS, Amidon KM, Mohni KN, Cortez D, Eichman BF. Protection of abasic sites during DNA replication by a stable thiazolidine protein-DNA cross-link. Nature Structural & Molecular Biology. PMID 31235915 DOI: 10.1107/S0108767319097988 |
0.514 |
|
| 2019 |
Cortez D. Replication-Coupled DNA Repair. Molecular Cell. 74: 866-876. PMID 31173722 DOI: 10.1016/J.Molcel.2019.04.027 |
0.563 |
|
| 2019 |
Thada V, Cortez D. Common motifs in ETAA1 and TOPBP1 required for ATR kinase activation. The Journal of Biological Chemistry. PMID 30940728 DOI: 10.1074/Jbc.Ra119.008154 |
0.577 |
|
| 2019 |
Bass TE, Cortez D. Quantitative phosphoproteomics reveals mitotic function of the ATR activator ETAA1. The Journal of Cell Biology. PMID 30755469 DOI: 10.1083/Jcb.201810058 |
0.537 |
|
| 2018 |
Mohni KN, Wessel SR, Zhao R, Wojciechowski AC, Luzwick JW, Layden H, Eichman BF, Thompson PS, Mehta KPM, Cortez D. HMCES Maintains Genome Integrity by Shielding Abasic Sites in Single-Strand DNA. Cell. PMID 30554877 DOI: 10.1016/J.Cell.2018.10.055 |
0.843 |
|
| 2018 |
Saldivar JC, Hamperl S, Bocek MJ, Chung M, Bass TE, Cisneros-Soberanis F, Samejima K, Xie L, Paulson JR, Earnshaw WC, Cortez D, Meyer T, Cimprich KA. An intrinsic S/G checkpoint enforced by ATR. Science (New York, N.Y.). 361: 806-810. PMID 30139873 DOI: 10.1126/Science.Aap9346 |
0.497 |
|
| 2018 |
Bhat KP, Krishnamoorthy A, Dungrawala H, Garcin EB, Modesti M, Cortez D. RADX Modulates RAD51 Activity to Control Replication Fork Protection. Cell Reports. 24: 538-545. PMID 30021152 DOI: 10.1016/J.Celrep.2018.06.061 |
0.628 |
|
| 2018 |
Carvajal-Maldonado D, Byrum AK, Jackson J, Wessel S, Lemaçon D, Guitton-Sert L, Quinet A, Tirman S, Graziano S, Masson JY, Cortez D, Gonzalo S, Mosammaparast N, Vindigni A. Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing. Nucleic Acids Research. PMID 29917110 DOI: 10.1093/Nar/Gky519 |
0.837 |
|
| 2018 |
Bhat KP, Cortez D. RPA and RAD51: fork reversal, fork protection, and genome stability. Nature Structural & Molecular Biology. PMID 29807999 DOI: 10.1038/S41594-018-0075-Z |
0.614 |
|
| 2017 |
Saldivar JC, Cortez D, Cimprich KA. Publisher correction: The essential kinase ATR: ensuring faithful duplication of a challenging genome. Nature Reviews. Molecular Cell Biology. PMID 29115300 DOI: 10.1038/Nrm.2017.116 |
0.331 |
|
| 2017 |
Poole LA, Cortez D. Functions of SMARCAL1, ZRANB3, and HLTF in maintaining genome stability. Critical Reviews in Biochemistry and Molecular Biology. 1-19. PMID 28954549 DOI: 10.1080/10409238.2017.1380597 |
0.623 |
|
| 2017 |
Vujanovic M, Krietsch J, Raso MC, Terraneo N, Zellweger R, Schmid JA, Taglialatela A, Huang JW, Holland CL, Zwicky K, Herrador R, Jacobs H, Cortez D, Ciccia A, Penengo L, et al. Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity. Molecular Cell. 67: 882-890.e5. PMID 28886337 DOI: 10.1016/J.Molcel.2017.08.010 |
0.597 |
|
| 2017 |
Saldivar JC, Cortez D, Cimprich KA. The essential kinase ATR: ensuring faithful duplication of a challenging genome. Nature Reviews. Molecular Cell Biology. PMID 28811666 DOI: 10.1038/Nrm.2017.67 |
0.598 |
|
| 2017 |
Dungrawala H, Bhat KP, Le Meur R, Chazin WJ, Ding X, Sharan SK, Wessel SR, Sathe AA, Zhao R, Cortez D. RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks. Molecular Cell. PMID 28735897 DOI: 10.1016/J.Molcel.2017.06.023 |
0.838 |
|
| 2017 |
Cortez D. Proteomic Analyses of the Eukaryotic Replication Machinery. Methods in Enzymology. 591: 33-53. PMID 28645376 DOI: 10.1016/Bs.Mie.2017.03.002 |
0.586 |
|
| 2017 |
Reynolds JJ, Bicknell LS, Carroll P, Higgs MR, Shaheen R, Murray JE, Papadopoulos DK, Leitch A, Murina O, Tarnauskaitė Ž, Wessel SR, Zlatanou A, Vernet A, von Kriegsheim A, Mottram RM, ... ... Cortez D, et al. Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism. Nature Genetics. PMID 28191891 DOI: 10.1038/Ng.3790 |
0.846 |
|
| 2017 |
Cortez D. Abstract IA14: Mechanisms of the ATR-dependent replication stress response Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-Ia14 |
0.514 |
|
| 2017 |
Chaudhuri AR, Callen E, Ding X, Gogola E, Duarte AA, Lee J, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, ... ... Cortez D, et al. Abstract IA09: Replication fork stability confers chemoresistance in BRCA-deficient cells Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-Ia09 |
0.583 |
|
| 2016 |
Puccetti MV, Fischer MA, Arrate MP, Boyd KL, Duszynski RJ, Bétous R, Cortez D, Eischen CM. Defective replication stress response inhibits lymphomagenesis and impairs lymphocyte reconstitution. Oncogene. PMID 27797382 DOI: 10.1038/Onc.2016.408 |
0.535 |
|
| 2016 |
Bass TE, Luzwick JW, Kavanaugh G, Carroll C, Dungrawala H, Glick GG, Feldkamp MD, Putney R, Chazin WJ, Cortez D. ETAA1 acts at stalled replication forks to maintain genome integrity. Nature Cell Biology. PMID 27723720 DOI: 10.1038/Ncb3415 |
0.619 |
|
| 2016 |
Ray Chaudhuri A, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, ... ... Cortez D, et al. Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature. 535: 382-7. PMID 27443740 DOI: 10.1038/Nature18325 |
0.603 |
|
| 2016 |
Poole LA, Cortez D. SMARCAL1 and telomeres: Replicating the troublesome ends. Nucleus (Austin, Tex.). 1-5. PMID 27355316 DOI: 10.1080/19491034.2016.1179413 |
0.616 |
|
| 2016 |
Badu-Nkansah A, Mason AC, Eichman BF, Cortez D. Identification of a Substrate Recognition Domain in the Replication Stress Response Protein Zinc Finger Ran-binding Domain Containing Protein 3 (ZRANB3). The Journal of Biological Chemistry. PMID 26884333 DOI: 10.1074/Jbc.M115.709733 |
0.541 |
|
| 2015 |
Poole LA, Zhao R, Glick GG, Lovejoy CA, Eischen CM, Cortez D. SMARCAL1 maintains telomere integrity during DNA replication. Proceedings of the National Academy of Sciences of the United States of America. PMID 26578802 DOI: 10.1073/Pnas.1510750112 |
0.84 |
|
| 2015 |
Cortez D, Zhou Z, Sanchez Y. Stephen Elledge and the DNA damage response. Dna Repair. 35: 156-7. PMID 26574138 DOI: 10.1016/J.Dnarep.2015.11.001 |
0.762 |
|
| 2015 |
Kavanaugh G, Ye F, Mohni KN, Luzwick JW, Glick G, Cortez D. A whole genome RNAi screen identifies replication stress response genes. Dna Repair. 35: 55-62. PMID 26454783 DOI: 10.1016/J.Dnarep.2015.09.024 |
0.544 |
|
| 2015 |
Dungrawala H, Rose KL, Bhat KP, Mohni KN, Glick GG, Couch FB, Cortez D. The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability. Molecular Cell. 59: 998-1010. PMID 26365379 DOI: 10.1016/J.Molcel.2015.07.030 |
0.594 |
|
| 2015 |
Kavanaugh G, Zhao R, Guo Y, Mohni KN, Glick G, Lacy ME, Hutson MS, Ascano M, Cortez D. Enhancer of Rudimentary Homolog affects the replication stress response through regulation of RNA processing. Molecular and Cellular Biology. PMID 26100022 DOI: 10.1128/Mcb.01276-14 |
0.557 |
|
| 2015 |
Mohni KN, Thompson PS, Luzwick JW, Glick GG, Pendleton CS, Lehmann BD, Pietenpol JA, Cortez D. A Synthetic Lethal Screen Identifies DNA Repair Pathways that Sensitize Cancer Cells to Combined ATR Inhibition and Cisplatin Treatments. Plos One. 10: e0125482. PMID 25965342 DOI: 10.1371/Journal.Pone.0125482 |
0.535 |
|
| 2015 |
Cortez D. Preventing replication fork collapse to maintain genome integrity. Dna Repair. 32: 149-57. PMID 25957489 DOI: 10.1016/J.Dnarep.2015.04.026 |
0.572 |
|
| 2015 |
Carroll C, Hunley TE, Guo Y, Cortez D. A novel splice site mutation in SMARCAL1 results in aberrant exon definition in a child with schimke immunoosseous dysplasia. American Journal of Medical Genetics. Part A. PMID 25943327 DOI: 10.1002/Ajmg.A.37146 |
0.384 |
|
| 2015 |
Ning B, Feldkamp MD, Cortez D, Chazin WJ, Friedman KL, Fanning E. Simian virus Large T antigen interacts with the N-terminal domain of the 70 kD subunit of Replication Protein A in the same mode as multiple DNA damage response factors. Plos One. 10: e0116093. PMID 25706313 DOI: 10.1371/Journal.Pone.0116093 |
0.498 |
|
| 2015 |
Bhat KP, Bétous R, Cortez D. High-affinity DNA-binding domains of replication protein A (RPA) direct SMARCAL1-dependent replication fork remodeling. The Journal of Biological Chemistry. 290: 4110-7. PMID 25552480 DOI: 10.1074/Jbc.M114.627083 |
0.548 |
|
| 2015 |
Dungrawala H, Cortez D. Purification of proteins on newly synthesized DNA using iPOND. Methods in Molecular Biology (Clifton, N.J.). 1228: 123-31. PMID 25311126 DOI: 10.1007/978-1-4939-1680-1_10 |
0.619 |
|
| 2014 |
Sowd GA, Mody D, Eggold J, Cortez D, Friedman KL, Fanning E. SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication products. Plos Pathogens. 10: e1004536. PMID 25474690 DOI: 10.1371/Journal.Ppat.1004536 |
0.633 |
|
| 2014 |
Luzwick JW, Nam EA, Zhao R, Cortez D. Mutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinase. Plos One. 9: e99397. PMID 24901225 DOI: 10.1371/Journal.Pone.0099397 |
0.539 |
|
| 2014 |
Mason AC, Rambo RP, Greer B, Pritchett M, Tainer JA, Cortez D, Eichman BF. A structure-specific nucleic acid-binding domain conserved among DNA repair proteins. Proceedings of the National Academy of Sciences of the United States of America. 111: 7618-23. PMID 24821763 DOI: 10.1073/Pnas.1324143111 |
0.549 |
|
| 2014 |
Mohni KN, Kavanaugh GM, Cortez D. ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency. Cancer Research. 74: 2835-45. PMID 24662920 DOI: 10.1158/0008-5472.Can-13-3229 |
0.514 |
|
| 2014 |
Couch FB, Cortez D. Fork reversal, too much of a good thing. Cell Cycle (Georgetown, Tex.). 13: 1049-50. PMID 24553113 DOI: 10.4161/Cc.28212 |
0.662 |
|
| 2014 |
Carroll C, Bansbach CE, Zhao R, Jung SY, Qin J, Cortez D. Phosphorylation of a C-terminal auto-inhibitory domain increases SMARCAL1 activity. Nucleic Acids Research. 42: 918-25. PMID 24150942 DOI: 10.1093/Nar/Gkt929 |
0.575 |
|
| 2014 |
Waterson AG, Frank AO, Vandgamudi B, Feldkamp MD, Souza-Fagundes EM, Luzwick JW, Cortez D, Olejniczak ET, Rossanese OW, Chazin WJ, Fesik SW. Abstract 3232: Optimization of a potent stapled helix peptide that binds to Replication Protein A Cancer Research. 74: 3232-3232. DOI: 10.1158/1538-7445.Am2014-3232 |
0.423 |
|
| 2013 |
Sirbu BM, McDonald WH, Dungrawala H, Badu-Nkansah A, Kavanaugh GM, Chen Y, Tabb DL, Cortez D. Identification of proteins at active, stalled, and collapsed replication forks using isolation of proteins on nascent DNA (iPOND) coupled with mass spectrometry. The Journal of Biological Chemistry. 288: 31458-67. PMID 24047897 DOI: 10.1074/Jbc.M113.511337 |
0.592 |
|
| 2013 |
Summers AR, Fischer MA, Stengel KR, Zhao Y, Kaiser JF, Wells CE, Hunt A, Bhaskara S, Luzwick JW, Sampathi S, Chen X, Thompson MA, Cortez D, Hiebert SW. HDAC3 is essential for DNA replication in hematopoietic progenitor cells. The Journal of Clinical Investigation. 123: 3112-23. PMID 23921131 DOI: 10.1172/Jci60806 |
0.379 |
|
| 2013 |
Wells CE, Bhaskara S, Stengel KR, Zhao Y, Sirbu B, Chagot B, Cortez D, Khabele D, Chazin WJ, Cooper A, Jacques V, Rusche J, Eischen CM, McGirt LY, Hiebert SW. Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. Plos One. 8: e68915. PMID 23894374 DOI: 10.1371/Journal.Pone.0068915 |
0.539 |
|
| 2013 |
Couch FB, Bansbach CE, Driscoll R, Luzwick JW, Glick GG, Bétous R, Carroll CM, Jung SY, Qin J, Cimprich KA, Cortez D. ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Genes & Development. 27: 1610-23. PMID 23873943 DOI: 10.1101/Gad.214080.113 |
0.659 |
|
| 2013 |
Sirbu BM, Cortez D. DNA damage response: three levels of DNA repair regulation. Cold Spring Harbor Perspectives in Biology. 5: a012724. PMID 23813586 DOI: 10.1101/Cshperspect.A012724 |
0.63 |
|
| 2013 |
Nagarajan P, Ge Z, Sirbu B, Doughty C, Agudelo Garcia PA, Schlederer M, Annunziato AT, Cortez D, Kenner L, Parthun MR. Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4. Plos Genetics. 9: e1003518. PMID 23754951 DOI: 10.1371/Journal.Pgen.1003518 |
0.335 |
|
| 2013 |
Bétous R, Couch FB, Mason AC, Eichman BF, Manosas M, Cortez D. Substrate-selective repair and restart of replication forks by DNA translocases. Cell Reports. 3: 1958-69. PMID 23746452 DOI: 10.1016/J.Celrep.2013.05.002 |
0.58 |
|
| 2013 |
Bétous R, Glick GG, Zhao R, Cortez D. Identification and characterization of SMARCAL1 protein complexes. Plos One. 8: e63149. PMID 23671665 DOI: 10.1371/Journal.Pone.0063149 |
0.563 |
|
| 2013 |
Carroll C, Badu-Nkansah A, Hunley T, Baradaran-Heravi A, Cortez D, Frangoul H. Schimke Immunoosseous Dysplasia associated with undifferentiated carcinoma and a novel SMARCAL1 mutation in a child. Pediatric Blood & Cancer. 60: E88-90. PMID 23630135 DOI: 10.1002/Pbc.24542 |
0.408 |
|
| 2013 |
Peixeiro N, Keller J, Collinet B, Leulliot N, Campanacci V, Cortez D, Cambillau C, Nitta KR, Vincentelli R, Forterre P, Prangishvili D, Sezonov G, van Tilbeurgh H. Structure and function of AvtR, a novel transcriptional regulator from a hyperthermophilic archaeal lipothrixvirus Journal of Virology. 87: 124-136. PMID 23055559 DOI: 10.1128/Jvi.01306-12 |
0.321 |
|
| 2013 |
Cortez D. Abstract ES01-1: Targeting the DNA damage response in triple negative breast cancer Cancer Research. 73. DOI: 10.1158/0008-5472.Sabcs13-Es01-1 |
0.548 |
|
| 2012 |
Sirbu BM, Couch FB, Cortez D. Monitoring the spatiotemporal dynamics of proteins at replication forks and in assembled chromatin using isolation of proteins on nascent DNA. Nature Protocols. 7: 594-605. PMID 22383038 DOI: 10.1038/Nprot.2012.010 |
0.6 |
|
| 2012 |
Bétous R, Mason AC, Rambo RP, Bansbach CE, Badu-Nkansah A, Sirbu BM, Eichman BF, Cortez D. SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication. Genes & Development. 26: 151-62. PMID 22279047 DOI: 10.1101/Gad.178459.111 |
0.588 |
|
| 2011 |
Nam EA, Zhao R, Cortez D. Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase. The Journal of Biological Chemistry. 286: 37320-7. PMID 21908846 DOI: 10.1074/Jbc.M111.276113 |
0.46 |
|
| 2011 |
Bansbach CE, Cortez D. Defining genome maintenance pathways using functional genomic approaches. Critical Reviews in Biochemistry and Molecular Biology. 46: 327-41. PMID 21787120 DOI: 10.3109/10409238.2011.588938 |
0.429 |
|
| 2011 |
Nam EA, Zhao R, Glick GG, Bansbach CE, Friedman DB, Cortez D. Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase. The Journal of Biological Chemistry. 286: 28707-14. PMID 21705319 DOI: 10.1074/Jbc.M111.248914 |
0.607 |
|
| 2011 |
Sirbu BM, Couch FB, Feigerle JT, Bhaskara S, Hiebert SW, Cortez D. Analysis of protein dynamics at active, stalled, and collapsed replication forks. Genes & Development. 25: 1320-7. PMID 21685366 DOI: 10.1101/Gad.2053211 |
0.583 |
|
| 2011 |
Nam EA, Cortez D. ATR signalling: more than meeting at the fork. The Biochemical Journal. 436: 527-36. PMID 21615334 DOI: 10.1042/Bj20102162 |
0.64 |
|
| 2011 |
Yu DS, Cortez D. A role for CDK9-cyclin K in maintaining genome integrity. Cell Cycle (Georgetown, Tex.). 10: 28-32. PMID 21200140 DOI: 10.4161/Cc.10.1.14364 |
0.543 |
|
| 2011 |
Bauer JA, Lehmann BD, Glick G, Cortez D, Lee E, Pietenpol JA. Abstract 951: Loss-of-function screening identifies therapeutic targets for triple negative breast cancer (TNBC) Cancer Research. 71: 951-951. DOI: 10.1158/1538-7445.Am2011-951 |
0.332 |
|
| 2011 |
Greenbaum M, Wiltshire T, Glick G, Bauer J, Lehmann B, Pietenpol J, Cortez D. Synthetic Lethal Relationships in the DNA Damage Response of Triple Negative Breast Cancer International Journal of Radiation Oncology*Biology*Physics. 81: S26. DOI: 10.1016/J.Ijrobp.2011.06.054 |
0.417 |
|
| 2010 |
Bansbach CE, Boerkoel CF, Cortez D. SMARCAL1 and replication stress: an explanation for SIOD? Nucleus (Austin, Tex.). 1: 245-8. PMID 21327070 DOI: 10.4161/Nucl.1.3.11739 |
0.623 |
|
| 2010 |
Yu DS, Zhao R, Hsu EL, Cayer J, Ye F, Guo Y, Shyr Y, Cortez D. Cyclin-dependent kinase 9-cyclin K functions in the replication stress response. Embo Reports. 11: 876-82. PMID 20930849 DOI: 10.1038/Embor.2010.153 |
0.527 |
|
| 2010 |
Mohni KN, Livingston CM, Cortez D, Weller SK. ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled. Journal of Virology. 84: 12152-64. PMID 20861269 DOI: 10.1128/Jvi.01643-10 |
0.566 |
|
| 2010 |
Soler N, Marguet E, Cortez D, Desnoues N, Keller J, van Tilbeurgh H, Sezonov G, Forterre P. Two novel families of plasmids from hyperthermophilic archaea encoding new families of replication proteins Nucleic Acids Research. 38: 5088-5104. PMID 20403814 DOI: 10.1093/nar/gkq236 |
0.304 |
|
| 2010 |
Wiltshire TD, Lovejoy CA, Wang T, Xia F, O'Connor MJ, Cortez D. Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair. The Journal of Biological Chemistry. 285: 14565-71. PMID 20233726 DOI: 10.1074/Jbc.M110.104745 |
0.837 |
|
| 2010 |
Bansbach CE, Boerkoel CF, Cortez D. SMARCAL1 and replication stress Nucleus. 1: 245-248. DOI: 10.4161/Nucl.11739 |
0.611 |
|
| 2009 |
Lovejoy CA, Xu X, Bansbach CE, Glick GG, Zhao R, Ye F, Sirbu BM, Titus LC, Shyr Y, Cortez D. Functional genomic screens identify CINP as a genome maintenance protein. Proceedings of the National Academy of Sciences of the United States of America. 106: 19304-9. PMID 19889979 DOI: 10.1073/Pnas.0909345106 |
0.818 |
|
| 2009 |
Bansbach CE, Bétous R, Lovejoy CA, Glick GG, Cortez D. The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. Genes & Development. 23: 2405-14. PMID 19793861 DOI: 10.1101/Gad.1839909 |
0.849 |
|
| 2009 |
Nam EA, Cortez D. SOSS1/2: Sensors of single-stranded DNA at a break. Molecular Cell. 35: 258-9. PMID 19683490 DOI: 10.1016/J.Molcel.2009.07.016 |
0.518 |
|
| 2009 |
Lovejoy CA, Cortez D. Common mechanisms of PIKK regulation. Dna Repair. 8: 1004-8. PMID 19464237 DOI: 10.1016/J.Dnarep.2009.04.006 |
0.816 |
|
| 2009 |
Yu D, Zhao R, Cortez D. A Synthetic Lethal Screen Identifies CDK9 as a Novel Replication Stress Response Protein International Journal of Radiation Oncology*Biology*Physics. 75: S18. DOI: 10.1016/J.Ijrobp.2009.07.065 |
0.356 |
|
| 2009 |
Mordes DA, Cortez D. Signaling at stalled replication forks The Dna Damage Response: Implications On Cancer Formation and Treatment. 25-45. DOI: 10.1007/978-90-481-2561-6_2 |
0.778 |
|
| 2008 |
Mordes DA, Nam EA, Cortez D. Dpb11 activates the Mec1-Ddc2 complex. Proceedings of the National Academy of Sciences of the United States of America. 105: 18730-4. PMID 19028869 DOI: 10.1073/Pnas.0806621105 |
0.772 |
|
| 2008 |
Xu X, Vaithiyalingam S, Glick GG, Mordes DA, Chazin WJ, Cortez D. The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling. Molecular and Cellular Biology. 28: 7345-53. PMID 18936170 DOI: 10.1128/Mcb.01079-08 |
0.801 |
|
| 2008 |
Mordes DA, Cortez D. Activation of ATR and related PIKKs. Cell Cycle (Georgetown, Tex.). 7: 2809-12. PMID 18769153 DOI: 10.4161/Cc.7.18.6689 |
0.78 |
|
| 2008 |
Cimprich KA, Cortez D. ATR: an essential regulator of genome integrity. Nature Reviews. Molecular Cell Biology. 9: 616-27. PMID 18594563 DOI: 10.1038/Nrm2450 |
0.646 |
|
| 2008 |
Mordes DA, Glick GG, Zhao R, Cortez D. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes & Development. 22: 1478-89. PMID 18519640 DOI: 10.1101/Gad.1666208 |
0.811 |
|
| 2008 |
Bhaskara S, Chyla BJ, Amann JM, Knutson SK, Cortez D, Sun ZW, Hiebert SW. Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Molecular Cell. 30: 61-72. PMID 18406327 DOI: 10.1016/J.Molcel.2008.02.030 |
0.545 |
|
| 2008 |
Yu D, Zhao R, Cortez D. Regulation of DNA Replication Fork Stabilization and Recovery in Response to DNA Damage International Journal of Radiation Oncology*Biology*Physics. 72: S694-S695. DOI: 10.1016/J.Ijrobp.2008.06.593 |
0.581 |
|
| 2007 |
Myers JS, Zhao R, Xu X, Ham AJ, Cortez D. Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage. Cancer Research. 67: 6685-90. PMID 17638878 DOI: 10.1158/0008-5472.Can-07-0495 |
0.506 |
|
| 2007 |
Chen X, Zhao R, Glick GG, Cortez D. Function of the ATR N-terminal domain revealed by an ATM/ATR chimera. Experimental Cell Research. 313: 1667-74. PMID 17376433 DOI: 10.1016/J.Yexcr.2007.02.015 |
0.58 |
|
| 2007 |
Ball HL, Ehrhardt MR, Mordes DA, Glick GG, Chazin WJ, Cortez D. Function of a conserved checkpoint recruitment domain in ATRIP proteins. Molecular and Cellular Biology. 27: 3367-77. PMID 17339343 DOI: 10.1128/Mcb.02238-06 |
0.813 |
|
| 2006 |
Lovejoy CA, Lock K, Yenamandra A, Cortez D. DDB1 maintains genome integrity through regulation of Cdt1. Molecular and Cellular Biology. 26: 7977-90. PMID 16940174 DOI: 10.1128/Mcb.00819-06 |
0.847 |
|
| 2006 |
Myers JS, Cortez D. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. The Journal of Biological Chemistry. 281: 9346-50. PMID 16431910 DOI: 10.1074/Jbc.M513265200 |
0.587 |
|
| 2005 |
Ball HL, Cortez D. ATRIP oligomerization is required for ATR-dependent checkpoint signaling. The Journal of Biological Chemistry. 280: 31390-6. PMID 16027118 DOI: 10.1074/Jbc.M504961200 |
0.582 |
|
| 2005 |
Cortez D. Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling. Genes & Development. 19: 1007-12. PMID 15879550 DOI: 10.1101/Gad.1316905 |
0.642 |
|
| 2005 |
Ball HL, Myers JS, Cortez D. ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Molecular Biology of the Cell. 16: 2372-81. PMID 15743907 DOI: 10.1091/Mbc.E04-11-1006 |
0.609 |
|
| 2004 |
Cortez D, Glick G, Elledge SJ. Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases Proceedings of the National Academy of Sciences of the United States of America. 101: 10078-10083. PMID 15210935 DOI: 10.1073/Pnas.0403410101 |
0.738 |
|
| 2003 |
Cortez D. Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases. The Journal of Biological Chemistry. 278: 37139-45. PMID 12847089 DOI: 10.1074/Jbc.M307088200 |
0.491 |
|
| 2002 |
Zou L, Cortez D, Elledge SJ. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin Genes and Development. 16: 198-208. PMID 11799063 DOI: 10.1101/Gad.950302 |
0.801 |
|
| 2001 |
Cortez D, Guntuku S, Qin J, Elledge SJ. ATR and ATRIP: Partners in checkpoint signaling Science. 294: 1713-1716. PMID 11721054 DOI: 10.1126/Science.1065521 |
0.734 |
|
| 2001 |
Paull TT, Cortez D, Bowers B, Elledge SJ, Gellert M. Direct DNA binding by Brca1 Proceedings of the National Academy of Sciences of the United States of America. 98: 6086-6091. PMID 11353843 DOI: 10.1073/Pnas.111125998 |
0.72 |
|
| 2000 |
Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, Abraham RT. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress Genes and Development. 14: 2989-3002. PMID 11114888 DOI: 10.1101/Gad.851000 |
0.718 |
|
| 2000 |
Cortez D, Elledge SJ. Conducting the mitotic symphony Nature. 406: 354-356. PMID 10935617 DOI: 10.1038/35019227 |
0.504 |
|
| 2000 |
Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJ. Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint Genes and Development. 14: 1448-1459. PMID 10859164 DOI: 10.1101/Gad.14.12.1448 |
0.681 |
|
| 2000 |
Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures Genes and Development. 14: 927-939. PMID 10783165 DOI: 10.1101/Gad.14.8.927 |
0.792 |
|
| 1999 |
Cortez D, Wang Y, Qin J, Elledge SJ. Requirement of ATM-dependent phosphorylation of Brca1 in the DNA damage response to double-strand breaks Science. 286: 1162-1166. PMID 10550055 DOI: 10.1126/Science.286.5442.1162 |
0.759 |
|
| 1998 |
Liu Q, Li MZ, Leibham D, Cortez D, Elledge SJ. The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes Current Biology. 8: 1300-1309. PMID 9843682 DOI: 10.1016/S0960-9822(07)00560-X |
0.592 |
|
| 1998 |
Dai Z, Quackenbush RC, Courtney KD, Grove M, Cortez D, Reuther GW, Pendergast AM. Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. Genes & Development. 12: 1415-24. PMID 9585502 DOI: 10.1101/Gad.12.10.1415 |
0.793 |
|
| 1998 |
Reuther JY, Reuther GW, Cortez D, Pendergast AM, Baldwin AS. A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation. Genes & Development. 12: 968-81. PMID 9531535 DOI: 10.1101/Gad.12.7.968 |
0.779 |
|
| 1997 |
Cortez D, Reuther G, Pendergast AM. The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells. Oncogene. 15: 2333-42. PMID 9393877 DOI: 10.1038/Sj.Onc.1201400 |
0.783 |
|
| 1995 |
Cortez D, Kadlec L, Pendergast AM. Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis. Molecular and Cellular Biology. 15: 5531-41. PMID 7565705 DOI: 10.1128/Mcb.15.10.5531 |
0.78 |
|
| 1995 |
Gishizky ML, Cortez D, Pendergast AM. Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation. Proceedings of the National Academy of Sciences of the United States of America. 92: 10889-93. PMID 7479904 DOI: 10.1073/Pnas.92.24.10889 |
0.675 |
|
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