| Year |
Citation |
Score |
| 2020 |
Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, et al. Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis. Cell Metabolism. PMID 32259482 DOI: 10.1016/J.Cmet.2020.03.010 |
0.322 |
|
| 2020 |
Smith CJ, Wagner AG, Stagnitta RT, Xu Z, Pezzullo JL, Giner JL, Xie J, Covey DF, Wang C, Callahan BP. Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis. Biochemistry. PMID 32013401 DOI: 10.1021/Acs.Biochem.0C00013 |
0.329 |
|
| 2020 |
Wang X, Radhakrishnan A, Covey D, Horton J, Schwabe R, Tontonoz P, Guan K, Tabas I. Abstract B04: Hepatic cholesterol upregulates TAZ in nonalcoholic steatohepatitis Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Hippo19-B04 |
0.31 |
|
| 2019 |
Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R. Cholesterol accessibility at the ciliary membrane controls Hedgehog signaling. Elife. 8. PMID 31657721 DOI: 10.7554/Elife.50051 |
0.315 |
|
| 2019 |
Rudolf AF, Kinnebrew M, Kowatsch C, Ansell TB, El Omari K, Bishop B, Pardon E, Schwab RA, Malinauskas T, Qian M, Duman R, Covey DF, Steyaert J, Wagner A, Sansom MSP, et al. The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nature Chemical Biology. PMID 31548691 DOI: 10.1038/S41589-019-0370-Y |
0.357 |
|
| 2019 |
Petersen D, Reinholdt P, Szomek M, Hansen SK, Poongavanam V, Dupont A, Heegaard CW, Krishnan K, Fujiwara H, Covey DF, Ory DS, Kongsted J, Wüstner D. Binding and intracellular transport of 25-hydroxycholesterol by Niemann-Pick C2 protein. Biochimica Et Biophysica Acta. Biomembranes. 183063. PMID 31521631 DOI: 10.1016/J.Bbamem.2019.183063 |
0.339 |
|
| 2019 |
Cheng WWL, Budelier MM, Sugasawa Y, Bergdoll L, Queralt-Martín M, Rosencrans W, Rostovtseva TK, Chen ZW, Abramson J, Krishnan K, Covey DF, Whitelegge JP, Evers AS. Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. PMID 31176038 DOI: 10.1016/J.Bbalip.2019.06.004 |
0.352 |
|
| 2019 |
Sugasawa Y, Bracamontes JR, Krishnan K, Covey DF, Reichert DE, Akk G, Chen Q, Tang P, Evers AS, Cheng WWL. The Molecular Determinants of Neurosteroid Binding in the GABA(A) Receptor. The Journal of Steroid Biochemistry and Molecular Biology. 105383. PMID 31150831 DOI: 10.1016/J.Jsbmb.2019.105383 |
0.312 |
|
| 2019 |
Feltes M, Moores S, Gale SE, Krishnan K, Mydock-McGrane L, Covey DF, Ory DS, Schaffer JE. Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking. Journal of Lipid Research. PMID 30617147 DOI: 10.1194/Jlr.D091470 |
0.361 |
|
| 2018 |
Budelier MM, Cheng WWL, Chen ZW, Bracamontes JR, Sugasawa Y, Kathiresan K, Mydock-McGrane L, Covey DF, Evers AS. Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. PMID 30471426 DOI: 10.1016/J.Bbalip.2018.11.005 |
0.355 |
|
| 2018 |
Shin DJ, Germann AL, Covey DF, Steinbach JH, Akk G. Analysis of GABAA receptor activation by combinations of agonists acting at the same or distinct binding sites. Molecular Pharmacology. PMID 30337372 DOI: 10.1124/Mol.118.113464 |
0.356 |
|
| 2018 |
Chisari M, Wilding TJ, Brunwasser S, Krishnan K, Qian M, Benz A, Huettner JE, Zorumski CF, Covey DF, Mennerick S. Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization. Neuropharmacology. PMID 30332607 DOI: 10.1016/J.Neuropharm.2018.10.015 |
0.324 |
|
| 2018 |
Cheng WWL, Chen ZW, Bracamontes JR, Budelier MM, Krishnan K, Shin DJ, Wang C, Jiang X, Covey DF, Akk G, Evers AS. Mapping Two Neurosteroid Modulatory Sites in the Prototypic Pentameric Ligand Gated Ion Channel GLIC. The Journal of Biological Chemistry. PMID 29301936 DOI: 10.1074/Jbc.Ra117.000359 |
0.306 |
|
| 2017 |
Budelier MM, Cheng WW, Bergdoll L, Chen ZW, Janetka JW, Abramson J, Krishnan K, Mydock-McGrane L, Covey DF, Whitelegge JP, Evers AS. Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1. The Journal of Biological Chemistry. PMID 28396346 DOI: 10.1074/Jbc.M116.773069 |
0.361 |
|
| 2017 |
Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R. Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex. Science (New York, N.Y.). 355: 1306-1311. PMID 28336668 DOI: 10.1126/Science.Aag1417 |
0.326 |
|
| 2017 |
Brownholland DP, Covey DF. Synthesis of Side-Chain Oxysterols and their Enantiomers through Cross-Metathesis Reactions of Δ(22) Steroids. Steroids. PMID 28300584 DOI: 10.1016/J.Steroids.2017.03.002 |
0.302 |
|
| 2016 |
Engler-Chiurazzi EB, Covey DF, Simpkins JW. A novel mechanism of non-feminizing estrogens in neuroprotection. Experimental Gerontology. PMID 27818250 DOI: 10.1016/J.Exger.2016.10.013 |
0.331 |
|
| 2016 |
Qian M, Engler-Chiurazzi EB, Lewis SE, Rath NP, Simpkins JW, Covey DF. Structure-activity studies of non-steroid analogues structurally-related to neuroprotective estrogens. Organic & Biomolecular Chemistry. PMID 27714297 DOI: 10.1039/C6Ob01726F |
0.327 |
|
| 2016 |
Luchetti G, Sircar R, Kong JH, Nachtergaele S, Sagner A, Byrne EF, Covey DF, Siebold C, Rohatgi R. Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling. Elife. 5. PMID 27705744 DOI: 10.7554/Elife.20304 |
0.336 |
|
| 2016 |
Jiang X, Shu HJ, Krishnan K, Qian M, Taylor AA, Covey DF, Zorumski CF, Mennerick S. A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition. Neuropharmacology. PMID 27114255 DOI: 10.1016/J.Neuropharm.2016.04.031 |
0.361 |
|
| 2016 |
Chakrabarti S, Qian M, Krishnan K, Covey DF, Mennerick S, Akk G. Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABAA Receptors. Molecular Pharmacology. PMID 26769414 DOI: 10.1124/Mol.115.102202 |
0.303 |
|
| 2015 |
Horváth G, Bencsura Á, Simon Á, Tochtrop GP, DeKoster GT, Covey DF, Cistola DP, Toke O. Structural determinants of ligand binding in the ternary complex of human ileal bile acid-binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR. The Febs Journal. PMID 26613247 DOI: 10.1111/Febs.13610 |
0.764 |
|
| 2015 |
Iaea DB, Gale SE, Bielska AA, Krishnan K, Fujiwara H, Jiang H, Maxfield FR, Schlesinger PH, Covey DF, Schaffer JE, Ory DS. A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol. Journal of Lipid Research. PMID 26497473 DOI: 10.1194/Jlr.D064287 |
0.343 |
|
| 2015 |
Mydock-McGrane L, Rath NP, Covey DF. Correction to Synthesis of a Smoothened Cholesterol: 18,19-Di-nor-cholesterol. The Journal of Organic Chemistry. 80: 6000. PMID 25988770 DOI: 10.1021/Acs.Joc.5B01073 |
0.318 |
|
| 2014 |
Bandari S, Chakraborty H, Covey DF, Chattopadhyay A. Membrane dipole potential is sensitive to cholesterol stereospecificity: implications for receptor function. Chemistry and Physics of Lipids. 184: 25-9. PMID 25219773 DOI: 10.1016/J.Chemphyslip.2014.09.001 |
0.335 |
|
| 2014 |
Linsenbardt AJ, Taylor A, Emnett CM, Doherty JJ, Krishnan K, Covey DF, Paul SM, Zorumski CF, Mennerick S. Different oxysterols have opposing actions at N-methyl-D-aspartate receptors. Neuropharmacology. 85: 232-42. PMID 24878244 DOI: 10.1016/J.Neuropharm.2014.05.027 |
0.357 |
|
| 2014 |
Mydock-McGrane L, Rath NP, Covey DF. Synthesis of a smoothened cholesterol: 18,19-di-nor-cholesterol. The Journal of Organic Chemistry. 79: 5636-43. PMID 24823889 DOI: 10.1021/Jo500813N |
0.362 |
|
| 2014 |
Bielska AA, Olsen BN, Gale SE, Mydock-McGrane L, Krishnan K, Baker NA, Schlesinger PH, Covey DF, Ory DS. Side-chain oxysterols modulate cholesterol accessibility through membrane remodeling. Biochemistry. 53: 3042-51. PMID 24758724 DOI: 10.1021/Bi5000096 |
0.332 |
|
| 2014 |
Chen ZW, Wang C, Krishnan K, Manion BD, Hastings R, Bracamontes J, Taylor A, Eaton MM, Zorumski CF, Steinbach JH, Akk G, Mennerick S, Covey DF, Evers AS. 11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors. Psychopharmacology. 231: 3479-91. PMID 24756762 DOI: 10.1007/S00213-014-3568-4 |
0.359 |
|
| 2014 |
Peyrot SM, Nachtergaele S, Luchetti G, Mydock-McGrane LK, Fujiwara H, Scherrer D, Jallouk A, Schlesinger PH, Ory DS, Covey DF, Rohatgi R. Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi. The Journal of Biological Chemistry. 289: 11095-110. PMID 24596093 DOI: 10.1074/Jbc.M113.540351 |
0.303 |
|
| 2014 |
Qian M, Krishnan K, Kudova E, Li P, Manion BD, Taylor A, Elias G, Akk G, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone. Journal of Medicinal Chemistry. 57: 171-90. PMID 24328079 DOI: 10.1021/Jm401577C |
0.699 |
|
| 2014 |
Drews A, Mohr F, Rizun O, Wagner TF, Dembla S, Rudolph S, Lambert S, Konrad M, Philipp SE, Behrendt M, Marchais-Oberwinkler S, Covey DF, Oberwinkler J. Structural requirements of steroidal agonists of transient receptor potential melastatin 3 (TRPM3) cation channels. British Journal of Pharmacology. 171: 1019-32. PMID 24251620 DOI: 10.1111/Bph.12521 |
0.324 |
|
| 2014 |
Jafurulla M, Rao BD, Sreedevi S, Ruysschaert JM, Covey DF, Chattopadhyay A. Stereospecific requirement of cholesterol in the function of the serotonin1A receptor. Biochimica Et Biophysica Acta. 1838: 158-63. PMID 24008092 DOI: 10.1016/J.Bbamem.2013.08.015 |
0.367 |
|
| 2013 |
Olsen BN, Bielska AA, Lee T, Daily MD, Covey DF, Schlesinger PH, Baker NA, Ory DS. The structural basis of cholesterol accessibility in membranes. Biophysical Journal. 105: 1838-47. PMID 24138860 DOI: 10.1016/J.Bpj.2013.08.042 |
0.338 |
|
| 2012 |
Chen ZW, Manion B, Townsend RR, Reichert DE, Covey DF, Steinbach JH, Sieghart W, Fuchs K, Evers AS. Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor. Molecular Pharmacology. 82: 408-19. PMID 22648971 DOI: 10.1124/Mol.112.078410 |
0.33 |
|
| 2012 |
Bielska AA, Schlesinger P, Covey DF, Ory DS. Oxysterols as non-genomic regulators of cholesterol homeostasis. Trends in Endocrinology and Metabolism: Tem. 23: 99-106. PMID 22244444 DOI: 10.1016/J.Tem.2011.12.002 |
0.323 |
|
| 2012 |
Krishnan K, Manion BD, Taylor A, Bracamontes J, Steinbach JH, Reichert DE, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors. Journal of Medicinal Chemistry. 55: 1334-45. PMID 22191644 DOI: 10.1021/Jm2014925 |
0.372 |
|
| 2012 |
Shu HJ, Bracamontes J, Taylor A, Wu K, Eaton MM, Akk G, Manion B, Evers AS, Krishnan K, Covey DF, Zorumski CF, Steinbach JH, Mennerick S. Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes. British Journal of Pharmacology. 165: 2228-43. PMID 21950777 DOI: 10.1111/J.1476-5381.2011.01690.X |
0.315 |
|
| 2011 |
D'Avanzo N, Hyrc K, Enkvetchakul D, Covey DF, Nichols CG. Enantioselective protein-sterol interactions mediate regulation of both prokaryotic and eukaryotic inward rectifier K+ channels by cholesterol. Plos One. 6: e19393. PMID 21559361 DOI: 10.1371/Journal.Pone.0019393 |
0.314 |
|
| 2011 |
Stastna E, Krishnan K, Manion BD, Taylor A, Rath NP, Chen ZW, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity. Journal of Medicinal Chemistry. 54: 3926-34. PMID 21504158 DOI: 10.1021/Jm2002487 |
0.357 |
|
| 2011 |
Bielska AA, Ory DS, Covey DF. Synthesis of the enantiomer of the oxysterol-antagonist LY295427. Steroids. 76: 986-90. PMID 21470559 DOI: 10.1016/J.Steroids.2011.03.008 |
0.35 |
|
| 2010 |
Bandyopadhyaya AK, Manion BD, Benz A, Taylor A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues. Bioorganic & Medicinal Chemistry Letters. 20: 6680-4. PMID 20875742 DOI: 10.1016/J.Bmcl.2010.09.008 |
0.358 |
|
| 2010 |
Akk G, Covey DF, Evers AS, Mennerick S, Zorumski CF, Steinbach JH. Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids. Current Neuropharmacology. 8: 18-25. PMID 20808543 DOI: 10.2174/157015910790909458 |
0.342 |
|
| 2010 |
Chisari M, Eisenman LN, Covey DF, Mennerick S, Zorumski CF. The sticky issue of neurosteroids and GABA(A) receptors. Trends in Neurosciences. 33: 299-306. PMID 20409596 DOI: 10.1016/J.Tins.2010.03.005 |
0.352 |
|
| 2010 |
Minogue S, Chu KM, Westover EJ, Covey DF, Hsuan JJ, Waugh MG. Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network. Journal of Lipid Research. 51: 2314-24. PMID 20388919 DOI: 10.1194/Jlr.M005751 |
0.776 |
|
| 2010 |
Evers AS, Chen ZW, Manion BD, Han M, Jiang X, Darbandi-Tonkabon R, Kable T, Bracamontes J, Zorumski CF, Mennerick S, Steinbach JH, Covey DF. A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors. The Journal of Pharmacology and Experimental Therapeutics. 333: 404-13. PMID 20124410 DOI: 10.1124/Jpet.109.164079 |
0.367 |
|
| 2010 |
CANNEY DJ, HOLLAND KD, LEVINE JA, MCKEON AC, FERRENDELLI JA, COVEY DF. ChemInform Abstract: Synthesis and Structure-Activity Studies of Alkyl-Substituted γ- Butyrolactones and γ-Thiobutyrolactones: Ligands for the Picrotoxin Receptor. Cheminform. 22: no-no. DOI: 10.1002/chin.199144152 |
0.689 |
|
| 2010 |
CANNEY DJ, LEVINE JA, LU H, COVEY DF. ChemInform Abstract: Facile Synthesis of α,β- and/or γ-Alkyl-Substituted . gamma.-Butyrolactones Using Readily Prepared Olefinic Esters. Cheminform. 22: no-no. DOI: 10.1002/chin.199109177 |
0.668 |
|
| 2010 |
Robinson CH, Covey DF. Biological formation and reactions The Chemistry of Ketenes, Allenes and Related Compounds: Part 1. 1: 451-485. DOI: 10.1002/9780470771600.ch13 |
0.472 |
|
| 2009 |
Li P, Bandyopadhyaya AK, Covey DF, Steinbach JH, Akk G. Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation. British Journal of Pharmacology. 158: 1322-9. PMID 19702782 DOI: 10.1111/J.1476-5381.2009.00390.X |
0.335 |
|
| 2009 |
Shu HJ, Eisenman LN, Wang C, Bandyopadhyaya AK, Krishnan K, Taylor A, Benz AM, Manion B, Evers AS, Covey DF, Zorumski CF, Mennerick S. Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors. Molecular Pharmacology. 76: 754-65. PMID 19596835 DOI: 10.1124/Mol.109.057687 |
0.371 |
|
| 2009 |
Chisari M, Eisenman LN, Krishnan K, Bandyopadhyaya AK, Wang C, Taylor A, Benz A, Covey DF, Zorumski CF, Mennerick S. The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction. Journal of Neurophysiology. 102: 1254-64. PMID 19553485 DOI: 10.1152/Jn.00346.2009 |
0.371 |
|
| 2009 |
Akk G, Covey DF, Evers AS, Steinbach JH, Zorumski CF, Mennerick S. The influence of the membrane on neurosteroid actions at GABA(A) receptors. Psychoneuroendocrinology. 34: S59-66. PMID 19541427 DOI: 10.1016/J.Psyneuen.2009.05.020 |
0.363 |
|
| 2009 |
Jin X, Covey DF, Steinbach JH. Kinetic analysis of voltage-dependent potentiation and block of the glycine alpha 3 receptor by a neuroactive steroid analogue. The Journal of Physiology. 587: 981-97. PMID 19124545 DOI: 10.1113/Jphysiol.2008.159343 |
0.306 |
|
| 2009 |
Katona BW, Anant S, Covey DF, Stenson WF. Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines. The Journal of Biological Chemistry. 284: 3354-64. PMID 19054763 DOI: 10.1074/Jbc.M805804200 |
0.585 |
|
| 2009 |
Gale SE, Westover EJ, Dudley N, Krishnan K, Merlin S, Scherrer DE, Han X, Zhai X, Brockman HL, Brown RE, Covey DF, Schaffer JE, Schlesinger P, Ory DS. Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions. The Journal of Biological Chemistry. 284: 1755-64. PMID 18996837 DOI: 10.1074/Jbc.M807210200 |
0.791 |
|
| 2008 |
Komarapuri S, Krishnan K, Covey DF. Synthesis of 19-Trideuterated ent-Testosterone and the GABA(A) Receptor Potentiators ent-Androsterone and ent-Etiocholanolone. Journal of Labelled Compounds & Radiopharmaceuticals. 51: 430-434. PMID 19122784 DOI: 10.1002/Jlcr.1558 |
0.334 |
|
| 2008 |
Akk G, Li P, Bracamontes J, Reichert DE, Covey DF, Steinbach JH. Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids. Molecular Pharmacology. 74: 614-27. PMID 18544665 DOI: 10.1124/Mol.108.048520 |
0.308 |
|
| 2008 |
Scaglione JB, Jastrzebska I, Krishnan K, Li P, Akk G, Manion BD, Benz A, Taylor A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes. Journal of Medicinal Chemistry. 51: 1309-18. PMID 18275132 DOI: 10.1021/Jm701128R |
0.791 |
|
| 2008 |
Alakoskela JM, Sabatini K, Jiang X, Laitala V, Covey DF, Kinnunen PK. Enantiospecific interactions between cholesterol and phospholipids. Langmuir : the Acs Journal of Surfaces and Colloids. 24: 830-6. PMID 18171092 DOI: 10.1021/La702909Q |
0.352 |
|
| 2008 |
Yi KD, Cai ZY, Covey DF, Simpkins JW. Estrogen receptor-independent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activation. The Journal of Pharmacology and Experimental Therapeutics. 324: 1188-95. PMID 18089844 DOI: 10.1124/Jpet.107.132308 |
0.311 |
|
| 2008 |
Katona BW, Krishnan K, Cai ZY, Manion BD, Benz A, Taylor A, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens. European Journal of Medicinal Chemistry. 43: 107-13. PMID 17434649 DOI: 10.1016/J.Ejmech.2007.02.017 |
0.623 |
|
| 2007 |
Wang C, Rath NP, Covey DF. Neurosteroid Analogues. 13. Synthetic methods for the preparation of 2beta-hydroxygonane derivatives as structural mimics of ent-3alpha-hydroxysteroid modulators of GABA(A) receptors. Tetrahedron. 63: 7977-7984. PMID 18698337 DOI: 10.1016/J.Tet.2007.05.068 |
0.321 |
|
| 2007 |
Katona BW, Cummins CL, Ferguson AD, Li T, Schmidt DR, Mangelsdorf DJ, Covey DF. Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids. Journal of Medicinal Chemistry. 50: 6048-58. PMID 17963371 DOI: 10.1021/Jm0707931 |
0.618 |
|
| 2007 |
Katona BW, Rath NP, Anant S, Stenson WF, Covey DF. Enantiomeric deoxycholic acid: total synthesis, characterization, and preliminary toxicity toward colon cancer cell lines. The Journal of Organic Chemistry. 72: 9298-307. PMID 17958446 DOI: 10.1021/Jo701559Q |
0.615 |
|
| 2007 |
Li P, Shu HJ, Wang C, Mennerick S, Zorumski CF, Covey DF, Steinbach JH, Akk G. Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation. The Journal of Physiology. 584: 789-800. PMID 17761771 DOI: 10.1113/Jphysiol.2007.142794 |
0.312 |
|
| 2007 |
Twede V, Tartaglia AL, Covey DF, Bamber BA. The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues. Molecular Pharmacology. 72: 1322-9. PMID 17715402 DOI: 10.1124/Mol.107.034058 |
0.327 |
|
| 2007 |
Kelley SP, Alan JK, O'Buckley TK, Mennerick S, Krishnan K, Covey DF, Leslie Morrow A. Antagonism of neurosteroid modulation of native gamma-aminobutyric acid receptors by (3alpha,5alpha)-17-phenylandrost-16-en-3-ol. European Journal of Pharmacology. 572: 94-101. PMID 17658511 DOI: 10.1016/J.Ejphar.2007.06.028 |
0.317 |
|
| 2007 |
Li W, Jin X, Covey DF, Steinbach JH. Neuroactive steroids and human recombinant rho1 GABAC receptors. The Journal of Pharmacology and Experimental Therapeutics. 323: 236-47. PMID 17636008 DOI: 10.1124/Jpet.107.127365 |
0.374 |
|
| 2007 |
Jastrzebska I, Scaglione JB, Dekoster GT, Rath NP, Covey DF. Palladium-catalyzed potassium enoxyborate alkylation of enantiopure Hajos-Parrish indenone to construct rearranged steroid ring systems. The Journal of Organic Chemistry. 72: 4837-43. PMID 17530900 DOI: 10.1021/Jo070530E |
0.771 |
|
| 2007 |
Akk G, Covey DF, Evers AS, Steinbach JH, Zorumski CF, Mennerick S. Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacology & Therapeutics. 116: 35-57. PMID 17524487 DOI: 10.1016/J.Pharmthera.2007.03.004 |
0.345 |
|
| 2007 |
Li P, Bracamontes J, Katona BW, Covey DF, Steinbach JH, Akk G. Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor. Molecular Pharmacology. 71: 1582-90. PMID 17341652 DOI: 10.1124/Mol.106.033407 |
0.607 |
|
| 2007 |
Eisenman LN, Shu HJ, Akk G, Wang C, Manion BD, Kress GJ, Evers AS, Steinbach JH, Covey DF, Zorumski CF, Mennerick S. Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light. Nature Neuroscience. 10: 523-30. PMID 17322875 DOI: 10.1038/Nn1862 |
0.336 |
|
| 2007 |
Cai ZY, Covey DF. A facile total synthesis of ent-17beta-estradiol and structurally related analogues. Steroids. 72: 351-9. PMID 17257636 DOI: 10.1016/J.Steroids.2006.12.007 |
0.309 |
|
| 2007 |
Alakoskela JM, Covey DF, Kinnunen PK. Lack of enantiomeric specificity in the effects of anesthetic steroids on lipid bilayers. Biochimica Et Biophysica Acta. 1768: 131-45. PMID 16945324 DOI: 10.1016/J.Bbamem.2006.07.011 |
0.37 |
|
| 2006 |
Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS. Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. Proceedings of the National Academy of Sciences of the United States of America. 103: 13807-12. PMID 16940355 DOI: 10.1073/Pnas.0606218103 |
0.322 |
|
| 2006 |
Westover EJ, Lin X, Riehl TE, Ma L, Stenson WF, Covey DF, Ostlund RE. Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters. Journal of Lipid Research. 47: 2374-81. PMID 16936324 DOI: 10.1194/Jlr.M600165-Jlr200 |
0.778 |
|
| 2006 |
VanLandingham JW, Cutler SM, Virmani S, Hoffman SW, Covey DF, Krishnan K, Hammes SR, Jamnongjit M, Stein DG. The enantiomer of progesterone acts as a molecular neuroprotectant after traumatic brain injury. Neuropharmacology. 51: 1078-85. PMID 16926035 DOI: 10.1016/J.Neuropharm.2006.07.015 |
0.303 |
|
| 2006 |
Yang C, McDonald JG, Patel A, Zhang Y, Umetani M, Xu F, Westover EJ, Covey DF, Mangelsdorf DJ, Cohen JC, Hobbs HH. Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. The Journal of Biological Chemistry. 281: 27816-26. PMID 16857673 DOI: 10.1074/Jbc.M603781200 |
0.8 |
|
| 2006 |
Scaglione JB, Manion BD, Benz A, Taylor A, DeKoster GT, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. Journal of Medicinal Chemistry. 49: 4595-605. PMID 16854065 DOI: 10.1021/Jm0602920 |
0.781 |
|
| 2006 |
Li P, Covey DF, Steinbach JH, Akk G. Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors. Molecular Pharmacology. 69: 2015-26. PMID 16554408 DOI: 10.1124/Mol.106.022590 |
0.363 |
|
| 2006 |
Li W, Covey DF, Alakoskela JM, Kinnunen PK, Steinbach JH. Enantiomers of neuroactive steroids support a specific interaction with the GABA-C receptor as the mechanism of steroid action. Molecular Pharmacology. 69: 1779-82. PMID 16527905 DOI: 10.1124/Mol.106.022863 |
0.367 |
|
| 2006 |
Westover EJ, Covey DF. Synthesis of ent-25-hydroxycholesterol. Steroids. 71: 484-8. PMID 16519912 DOI: 10.1016/J.Steroids.2006.01.007 |
0.78 |
|
| 2005 |
Akk G, Shu HJ, Wang C, Steinbach JH, Zorumski CF, Covey DF, Mennerick S. Neurosteroid access to the GABAA receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11605-13. PMID 16354918 DOI: 10.1523/Jneurosci.4173-05.2005 |
0.326 |
|
| 2005 |
Cenedella RJ, Sexton PS, Krishnan K, Covey DF. Comparison of effects of U18666A and enantiomeric U18666A on sterol synthesis and induction of apoptosis. Lipids. 40: 635-40. PMID 16149744 DOI: 10.1007/S11745-005-1426-9 |
0.331 |
|
| 2005 |
Liu J, Chang CC, Westover EJ, Covey DF, Chang TY. Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies. The Biochemical Journal. 391: 389-97. PMID 15992359 DOI: 10.1042/Bj20050428 |
0.796 |
|
| 2005 |
Zeng CM, Manion BD, Benz A, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. Journal of Medicinal Chemistry. 48: 3051-9. PMID 15828844 DOI: 10.1021/Jm049027+ |
0.356 |
|
| 2005 |
Kumar DM, Perez E, Cai ZY, Aoun P, Brun-Zinkernagel AM, Covey DF, Simpkins JW, Agarwal N. Role of nonfeminizing estrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicity. Free Radical Biology & Medicine. 38: 1152-63. PMID 15808412 DOI: 10.1016/J.Freeradbiomed.2004.12.007 |
0.317 |
|
| 2005 |
Perez E, Liu R, Yang SH, Cai ZY, Covey DF, Simpkins JW. Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo. Brain Research. 1038: 216-22. PMID 15757637 DOI: 10.1016/J.Brainres.2005.01.026 |
0.324 |
|
| 2005 |
Scaglione JB, Rath NP, Covey DF. First synthesis of enantiopure 1,6-difunctionalized dodecahydrobenz[f]indenes. The Journal of Organic Chemistry. 70: 1089-92. PMID 15675880 DOI: 10.1021/Jo048561M |
0.76 |
|
| 2005 |
Cegelski L, Rice CV, O'Connor RD, Caruano AL, Tochtrop GP, Cai ZY, Covey DF, Schaefer J. Mapping the locations of estradiol and potent neuroprotective analogues in phospholipid bilayers by REDOR Drug Development Research. 66: 93-102. DOI: 10.1002/Ddr.20048 |
0.647 |
|
| 2005 |
Perez E, Cai ZY, Covey DF, Simpkins JW. Neuroprotective effects of estratriene analogs: Structure-activity relationships and molecular optimization Drug Development Research. 66: 78-92. DOI: 10.1002/Ddr.20047 |
0.318 |
|
| 2004 |
Westover EJ, Covey DF. The enantiomer of cholesterol. The Journal of Membrane Biology. 202: 61-72. PMID 15702370 DOI: 10.1007/S00232-004-0714-7 |
0.772 |
|
| 2004 |
Simpkins JW, Yang SH, Liu R, Perez E, Cai ZY, Covey DF, Green PS. Estrogen-like compounds for ischemic neuroprotection. Stroke; a Journal of Cerebral Circulation. 35: 2648-51. PMID 15472107 DOI: 10.1161/01.Str.0000143734.59507.88 |
0.314 |
|
| 2004 |
Tochtrop GP, DeKoster GT, Covey DF, Cistola DP. A single hydroxyl group governs ligand site selectivity in human ileal bile acid binding protein. Journal of the American Chemical Society. 126: 11024-9. PMID 15339188 DOI: 10.1021/Ja047589C |
0.762 |
|
| 2004 |
Shu HJ, Eisenman LN, Jinadasa D, Covey DF, Zorumski CF, Mennerick S. Slow actions of neuroactive steroids at GABAA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6667-75. PMID 15282269 DOI: 10.1523/Jneurosci.1399-04.2004 |
0.334 |
|
| 2004 |
Li Y, Ge M, Ciani L, Kuriakose G, Westover EJ, Dura M, Covey DF, Freed JH, Maxfield FR, Lytton J, Tabas I. Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages. The Journal of Biological Chemistry. 279: 37030-9. PMID 15215242 DOI: 10.1074/Jbc.M405195200 |
0.774 |
|
| 2004 |
Akk G, Bracamontes JR, Covey DF, Evers A, Dao T, Steinbach JH. Neuroactive steroids have multiple actions to potentiate GABAA receptors. The Journal of Physiology. 558: 59-74. PMID 15146041 DOI: 10.1113/Jphysiol.2004.066571 |
0.318 |
|
| 2004 |
Mennerick S, He Y, Jiang X, Manion BD, Wang M, Shute A, Benz A, Evers AS, Covey DF, Zorumski CF. Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors. Molecular Pharmacology. 65: 1191-7. PMID 15102947 DOI: 10.1124/Mol.65.5.1191 |
0.314 |
|
| 2004 |
Das P, Bell-Horner CL, Huang RQ, Raut A, Gonzales EB, Chen ZL, Covey DF, Dillon GH. Inhibition of type A GABA receptors by L-type calcium channel blockers. Neuroscience. 124: 195-206. PMID 14960351 DOI: 10.1016/J.Neuroscience.2003.12.005 |
0.344 |
|
| 2004 |
Gonzales EB, Bell-Horner CL, de la Cruz MA, Ferrendelli JA, Covey DF, Dillon GH. Enantioselectivity of alpha-benzyl-alpha-methyl-gamma-butyrolactone-mediated modulation of anticonvulsant activity and GABA(A) receptor function. The Journal of Pharmacology and Experimental Therapeutics. 309: 677-83. PMID 14742738 DOI: 10.1124/Jpet.103.063008 |
0.34 |
|
| 2004 |
Darbandi-Tonkabon R, Manion BD, Hastings WR, Craigen WJ, Akk G, Bracamontes JR, He Y, Sheiko TV, Steinbach JH, Mennerick SJ, Covey DF, Evers AS. Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia. The Journal of Pharmacology and Experimental Therapeutics. 308: 502-11. PMID 14593090 DOI: 10.1124/Jpet.103.058123 |
0.342 |
|
| 2003 |
Jiang X, Manion BD, Benz A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. Journal of Medicinal Chemistry. 46: 5334-48. PMID 14640542 DOI: 10.1021/Jm030302M |
0.345 |
|
| 2003 |
Zitzer A, Westover EJ, Covey DF, Palmer M. Differential interaction of the two cholesterol-dependent, membrane-damaging toxins, streptolysin O and Vibrio cholerae cytolysin, with enantiomeric cholesterol. Febs Letters. 553: 229-31. PMID 14572629 DOI: 10.1016/S0014-5793(03)01023-8 |
0.783 |
|
| 2003 |
Westover EJ, Covey DF, Brockman HL, Brown RE, Pike LJ. Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomers. The Journal of Biological Chemistry. 278: 51125-33. PMID 14530278 DOI: 10.1074/Jbc.M304332200 |
0.793 |
|
| 2003 |
Tochtrop GP, Bruns JL, Tang C, Covey DF, Cistola DP. Steroid ring hydroxylation patterns govern cooperativity in human bile acid binding protein. Biochemistry. 42: 11561-7. PMID 14529265 DOI: 10.1021/Bi0346502 |
0.772 |
|
| 2003 |
Westover EJ, Covey DF. First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol. Steroids. 68: 159-66. PMID 12606007 DOI: 10.1016/S0039-128X(02)00174-5 |
0.782 |
|
| 2003 |
Darbandi-Tonkabon R, Hastings WR, Zeng CM, Akk G, Manion BD, Bracamontes JR, Steinbach JH, Mennerick SJ, Covey DF, Evers AS. Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain. The Journal of Biological Chemistry. 278: 13196-206. PMID 12560326 DOI: 10.1074/Jbc.M213168200 |
0.33 |
|
| 2003 |
Mannock DA, McIntosh TJ, Jiang X, Covey DF, McElhaney RN. Effects of natural and enantiomeric cholesterol on the thermotropic phase behavior and structure of egg sphingomyelin bilayer membranes. Biophysical Journal. 84: 1038-46. PMID 12547785 DOI: 10.1016/S0006-3495(03)74920-0 |
0.329 |
|
| 2003 |
Auchus RJ, Kumar AS, Boswell CA, Gupta MK, Bruce K, Rath NP, Covey DF. The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21 Archives of Biochemistry and Biophysics. 409: 134-144. PMID 12464252 DOI: 10.1016/S0003-9861(02)00491-5 |
0.33 |
|
| 2002 |
Tochtrop GP, DeKoster GT, Cistola DP, Covey DF. Synthesis of [3,4-(13)c(2)]-enriched bile salts as NMR probes of protein-ligand interactions. The Journal of Organic Chemistry. 67: 6764-71. PMID 12227809 DOI: 10.1021/Jo0259109 |
0.768 |
|
| 2002 |
Jiang X, Covey DF. Total synthesis of ent-cholesterol via a steroid C,D-ring side-chain synthon Journal of Organic Chemistry. 67: 4893-4900. PMID 12098302 DOI: 10.1021/Jo025535K |
0.344 |
|
| 2002 |
Meyer DA, Carta M, Partridge LD, Covey DF, Valenzuela CF. Neurosteroids enhance spontaneous glutamate release in hippocampal neurons. Possible role of metabotropic sigma1-like receptors. The Journal of Biological Chemistry. 277: 28725-32. PMID 12042305 DOI: 10.1074/Jbc.M202592200 |
0.303 |
|
| 2002 |
Wang M, He Y, Eisenman LN, Fields C, Zeng CM, Mathews J, Benz A, Fu T, Zorumski E, Steinbach JH, Covey DF, Zorumski CF, Mennerick S. 3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3366-75. PMID 11978813 DOI: 10.1523/Jneurosci.22-09-03366.2002 |
0.307 |
|
| 2002 |
Xia S, Cai ZY, Thio LL, Kim-Han JS, Dugan LL, Covey DF, Rothman SM. The estrogen receptor is not essential for all estrogen neuroprotection: new evidence from a new analog. Neurobiology of Disease. 9: 282-93. PMID 11950274 DOI: 10.1006/Nbdi.2002.0478 |
0.3 |
|
| 2002 |
Tochtrop GP, Richter K, Tang C, Toner JJ, Covey DF, Cistola DP. Energetics by NMR: site-specific binding in a positively cooperative system. Proceedings of the National Academy of Sciences of the United States of America. 99: 1847-52. PMID 11854486 DOI: 10.1073/Pnas.012379199 |
0.752 |
|
| 2002 |
Tochtrop GP, DeKoster GT, Cistola DP, Covey DF. A simple efficient synthesis of [23,24]-(13)C(2)-labeled bile salts as NMR probes of protein-ligand interactions. Bioorganic & Medicinal Chemistry Letters. 12: 433-5. PMID 11814814 DOI: 10.1016/S0960-894X(01)00763-6 |
0.758 |
|
| 2002 |
He Y, Benz A, Fu T, Wang M, Covey DF, Zorumski CF, Mennerick S. Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function. Neuropharmacology. 42: 199-209. PMID 11804616 DOI: 10.1016/S0028-3908(01)00175-7 |
0.309 |
|
| 2001 |
Vallée M, Shen W, Heinrichs SC, Zorumski CF, Covey DF, Koob GF, Purdy RH. Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats. The European Journal of Neuroscience. 14: 2003-10. PMID 11860495 DOI: 10.1046/J.0953-816X.2001.01817.X |
0.306 |
|
| 2001 |
Covey DF, Evers AS, Mennerick S, Zorumski CF, Purdy RH. Recent developments in structure-activity relationships for steroid modulators of GABA(A) receptors. Brain Research. Brain Research Reviews. 37: 91-7. PMID 11744077 DOI: 10.1016/S0165-0173(01)00126-6 |
0.355 |
|
| 2001 |
Crowder CM, Westover EJ, Kumar AS, Ostlund RE, Covey DF. Enantiospecificity of cholesterol function in vivo. The Journal of Biological Chemistry. 276: 44369-72. PMID 11598105 DOI: 10.1074/Jbc.C100535200 |
0.774 |
|
| 2001 |
Lalitha S, Sampath Kumar A, Stine KJ, Covey DF. Chirality in Membranes: First Evidence that Enantioselective Interactions Between Cholesterol and Cell Membrane Lipids Can Be a Determinant of Membrane Physical Properties Journal of Supramolecular Chemistry. 1: 53-61. DOI: 10.1016/S1472-7862(01)00013-2 |
0.343 |
|
| 2000 |
Chang Y, Covey DF, Weiss DS. Correlation of the apparent affinities and efficacies of gamma-aminobutyric acid(C) receptor agonists. Molecular Pharmacology. 58: 1375-80. PMID 11093776 DOI: 10.1124/Mol.58.6.1375 |
0.341 |
|
| 2000 |
Paradiso K, Sabey K, Evers AS, Zorumski CF, Covey DF, Steinbach JH. Steroid inhibition of rat neuronal nicotinic alpha4beta2 receptors expressed in HEK 293 cells. Molecular Pharmacology. 58: 341-51. PMID 10908302 DOI: 10.1124/Mol.58.2.341 |
0.34 |
|
| 2000 |
Luker GD, Pica CM, Kumar AS, Covey DF, Piwnica-Worms D. Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains. Biochemistry. 39: 7651-61. PMID 10869171 DOI: 10.1021/Bi9928593 |
0.328 |
|
| 1999 |
Hill MW, de la Cruz MA, Covey DF, Rothman SM. Effects of anticonvulsant lactams on in vitro seizures in the hippocampal slice preparation. Epilepsy Research. 37: 121-31. PMID 10510978 DOI: 10.1016/S0920-1211(99)00041-8 |
0.335 |
|
| 1999 |
Luker GD, Nilsson KR, Covey DF, Piwnica-Worms D. Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol Journal of Biological Chemistry. 274: 6979-6991. PMID 10066752 DOI: 10.1074/Jbc.274.11.6979 |
0.312 |
|
| 1998 |
Nilsson KR, Zorumski CF, Covey DF. Neurosteroid analogues. 6. The synthesis and GABA(A) receptor pharmacology of enantiomers of dehydroepiandrosterone sulfate, pregnenolone sulfate, and (3α,5β)-3-hydroxypregnan-20-one sulfate Journal of Medicinal Chemistry. 41: 2604-2613. PMID 9651164 DOI: 10.1021/Jm980148H |
0.333 |
|
| 1998 |
Canney DJ, Lu HF, McKeon AC, Yoon KW, Xu K, Holland KD, Rothman SM, Ferrendelli JA, Covey DF. Structure-activity studies of fluoroalkyl-substituted gamma-butyrolactone and gamma-thiobutyrolactone modulators of GABA(A) receptor function. Bioorganic & Medicinal Chemistry. 6: 43-55. PMID 9502104 DOI: 10.1016/S0968-0896(97)10006-2 |
0.725 |
|
| 1997 |
Williams KL, Tucker JB, White G, Weiss DS, Ferrendelli JA, Covey DF, Krause JE, Rothman SM. Lactone modulation of the gamma-aminobutyric acid A receptor: evidence for a positive modulatory site. Molecular Pharmacology. 52: 114-9. PMID 9224820 DOI: 10.1124/Mol.52.1.114 |
0.317 |
|
| 1996 |
Zorumski CF, Wittmer LL, Isenberg KE, Hu Y, Covey DF. Effects of neurosteroid and benz[e]indene enantiomers on GABA(A) receptors in cultured hippocampal neurons and transfected HEK-293 cells Neuropharmacology. 35: 1161-1168. PMID 9014131 DOI: 10.1016/S0028-3908(96)00035-4 |
0.307 |
|
| 1996 |
Han M, Zorumski CF, Covey DF. Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABA(A) receptors Journal of Medicinal Chemistry. 39: 4218-4232. PMID 8863799 DOI: 10.1021/Jm960304P |
0.34 |
|
| 1995 |
Jakoby IV MG, Covey DF, Cistola DP. Localization of tolbutamide binding sites on human serum albumin using titration calorimetry and heteronuclear 2-D NMR Biochemistry. 34: 8780-8787. PMID 7612618 DOI: 10.1021/Bi00027A029 |
0.632 |
|
| 1995 |
Han M, Hu Y, Zorumski CF, Covey DF. Neurosteroid analogues. 3. The synthesis and electrophysiological evaluation of benz[e]indene congeners of neuroactive steroids having the 5β- configuration Journal of Medicinal Chemistry. 38: 4548-4556. PMID 7473583 DOI: 10.1021/Jm00022A021 |
0.325 |
|
| 1995 |
Tinao-Wooldridge LV, Hsiang BCH, Latifi TN, Ferrendelli JA, Covey DF. Partial structures of the fungal toxin aflatrem, methyl-substituted 6,8-dioxabicyclo[3.2.1]octan-2-ones have anticonvulsant activity Bioorganic and Medicinal Chemistry Letters. 5: 265-270. DOI: 10.1016/0960-894X(95)00021-K |
0.322 |
|
| 1994 |
Peterson EM, Xu K, Holland KD, McKeon AC, Rothman SM, Ferrendelli JA, Covey DF. Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones. Journal of Medicinal Chemistry. 37: 275-86. PMID 8295215 DOI: 10.1021/Jm00028A011 |
0.323 |
|
| 1994 |
Mathews GC, Bolos-Sy AM, Holland KD, Isenberg KE, Covey DF, Ferrendelli JA, Rothman SM. Developmental alteration in GABAA receptor structure and physiological properties in cultured cerebellar granule neurons. Neuron. 13: 149-58. PMID 8043274 DOI: 10.1016/0896-6273(94)90465-0 |
0.314 |
|
| 1993 |
Canney DJ, Covey DF, Evers AS. Direct observation of a fluorinated anticonvulsant in brain tissue using 19F-NMR techniques. Biochemical Pharmacology. 45: 949-59. PMID 8452571 DOI: 10.1016/0006-2952(93)90181-U |
0.695 |
|
| 1993 |
Holland KD, Bouley MG, Covey DF, Ferrendelli JA. Alkyl-substituted gamma-butyrolactones act at a distinct site allosterically linked to the TBPS/picrotoxinin site on the GABAA receptor complex. Brain Research. 615: 170-4. PMID 8395954 DOI: 10.1016/0006-8993(93)91128-F |
0.356 |
|
| 1993 |
Hu Y, Zorumski CF, Covey DF. Neurosteroid analogues: structure-activity studies of benz[e]indene modulators of gabaA receptor function. 1. the effect of 6-methyl substitution on the electrophysiological activity of 7-substituted benz[e]indene-3-carbonitriles Journal of Medicinal Chemistry®. 36: 3956-3967. PMID 8254624 DOI: 10.1021/Jm00076A025 |
0.323 |
|
| 1993 |
Yoon KW, Covey DF, Rothman SM. Multiple mechanisms of picrotoxin block of GABA-induced currents in rat hippocampal neurons. The Journal of Physiology. 464: 423-39. PMID 8229811 DOI: 10.1113/Jphysiol.1993.Sp019643 |
0.316 |
|
| 1993 |
Holland KD, McKeon AC, Canney DJ, Covey DF, Ferrendelli JA. Relative anticonvulsant effects of GABAmimetic and GABA modulatory agents. Epilepsia. 33: 981-6. PMID 1334454 DOI: 10.1111/J.1528-1157.1992.Tb01747.X |
0.701 |
|
| 1992 |
Thomas JL, Strickler RC, Myers RP, Covey DF. Affinity labeling of human placental 3 beta-hydroxy-delta 5-steroid dehydrogenase and steroid delta-isomerase: evidence for bifunctional catalysis by a different conformation of the same protein for each enzyme activity. Biochemistry. 31: 5522-7. PMID 1610797 DOI: 10.1021/Bi00139A014 |
0.324 |
|
| 1991 |
Canney DJ, Holland KD, Levine JA, McKeon AC, Ferrendelli JA, Covey DF. Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor. Journal of Medicinal Chemistry. 34: 1460-7. PMID 1849999 DOI: 10.1021/Jm00108A034 |
0.725 |
|
| 1990 |
Holland KD, Canney DJ, Rothman SM, Ferrendelli JA, Covey DF. Physiological modulation of the GABA receptor by convulsant and anticonvulsant barbiturates in cultured rat hippocampal neurons. Brain Research. 516: 147-50. PMID 2163720 DOI: 10.1016/0006-8993(90)90910-4 |
0.695 |
|
| 1990 |
Canney DJ, Levine JA, Lu H, Covey DF. Facile Synthesis of α, β, and/or γ-Alkyl-Substituted γ-Butyrolactones Using Readily Prepared Olefinic Esters Synthetic Communications. 20: 2065-2073. DOI: 10.1080/00397919008053138 |
0.695 |
|
| 1989 |
Sherwin PF, McMullan PC, Covey DF. Effects of steroid D-ring modification on suicide inactivation and competitive inhibition of aromatase by analogues of androsta-1,4-diene-3,17-dione. Journal of Medicinal Chemistry. 32: 651-8. PMID 2918514 DOI: 10.1021/Jm00123A026 |
0.31 |
|
| 1989 |
Auchus RJ, Palmer JO, Carrell HL, Covey DF. Preparation of 14,15-secoestra-1,3,5(10)-trien-15-ynes, inhibitors of estradiol dehydrogenase. Steroids. 53: 77-96. PMID 2772972 DOI: 10.1016/0039-128X(89)90147-5 |
0.357 |
|
| 1986 |
Covey DF, Hood WF, McMullan PC. Studies of the inactivation of human placental aromatase by 17 alpha-ethynyl-substituted 10 beta-hydroperoxy and related 19-nor steroids. Biochemical Pharmacology. 35: 1671-4. PMID 3707596 DOI: 10.1016/0006-2952(86)90321-7 |
0.325 |
|
| 1981 |
Penning TM, Covey DF, Talalay P. Inactivation of delta 5-3-oxo steroid isomerase with active-site-directed acetylenic steroids Biochemical Journal. 193: 217-227. PMID 7305923 DOI: 10.1042/Bj1930217 |
0.348 |
|
| 1980 |
Highet RJ, Covey DF, Robinson CH. Carbon-13 nuclear magnetic resonance spectra of 5,10-secosteroids. A transannular intramolecular hydrogen bond The Journal of Organic Chemistry. 45: 3286-3289. DOI: 10.1021/Jo01304A029 |
0.527 |
|
| 1979 |
Covey DF, Albert KA, Robinson CH. Model studies with enzyme inhibitors. Addition of nucleophiles to conjugated allenic 3-oxo-5,10-secosteroids Journal of the Chemical Society, Chemical Communications. 795-796. DOI: 10.1039/C39790000795 |
0.561 |
|
| 1978 |
Voigt W, Castro A, Covey DF, Robinson CH. Inhibition of testosterone 5 alpha-reductase by and antiandrogenicity of allenic 3-keto-5,10-secosteroids. Acta Endocrinologica. 87: 668-72. PMID 580152 DOI: 10.1530/acta.0.0870668 |
0.502 |
|
| 1978 |
Carrell HL, Glusker JP, Covey DF, Batzold FH, Robinson CH. Molecular structures of substrates and inhibitors of .DELTA.5-3-keto steroid isomerase and their relevance to the enzymic mechanism Journal of the American Chemical Society. 100: 4282-4289. DOI: 10.1021/Ja00481A045 |
0.55 |
|
| 1978 |
Carrell HL, Glusker JP, Covey DF, Batzold FH, Robinson CH. Molecular Structures Of Substrates And Inhibitors Of Δ5-3-Keto Steroid Isomerase And Their Relevance To The Enzymic Mechanism Cheminform. 9. DOI: 10.1002/Chin.197839064 |
0.548 |
|
| 1977 |
Batzold FH, Benson AM, Covey DF, Robinson CH, Talalay P. [51] Irreversible inhibitors of Δ 5-3-ketosteroid isomerase: Acetylenic and allenic 3-oxo-5,10-secosteroids Methods in Enzymology. 46: 461-468. PMID 909438 DOI: 10.1016/S0076-6879(77)46055-5 |
0.575 |
|
| 1977 |
Robaire B, Covey DF, Robinson CH, Ewing LL. Selective inhibition of rat epididymal steroid delta4-5alpha-reductase by conjugated allenic 3-oxo-5, 10-secosteroids. Journal of Steroid Biochemistry. 8: 307-10. PMID 886861 DOI: 10.1016/0022-4731(77)90024-3 |
0.51 |
|
| 1977 |
Covey DF, Nickon A. Difunctionalized brendanes via thallium triacetate cleavage of the cyclopropyl ring of triaxane The Journal of Organic Chemistry. 42: 794-799. DOI: 10.1021/Jo00425A006 |
0.602 |
|
| 1977 |
Amzel LM, Covey DF, Fenselau C, Nickon A, Robinson CH. Organic structural analysis. J. B. Lambert, H. F. Shurvell, L. Berbit, R. G. Cooks, G. H. Stout, Macmillan Publishing Co. Inc., New York, N. Y., 1976. 596 pp. $22.95 Biological Mass Spectrometry. 4: vii-ix. DOI: 10.1002/Bms.1200040612 |
0.468 |
|
| 1976 |
Covey DF, Robinson CH. Letter: Conjugated allenic 3-oxo-5,10-secosteroids. Irreversible inhibitors of delta 5-3-ketosteroid isomerase. Journal of the American Chemical Society. 98: 5038-40. PMID 950427 DOI: 10.1021/Ja00432A067 |
0.554 |
|
| 1976 |
Batzold FH, Benson AM, Covey DF, Robinson CH, Talalay P. The delta 5-3-ketosteroid isomerase reaction: catalytic mechanism, specificity and inhibition. Advances in Enzyme Regulation. 14: 243-67. PMID 9789 DOI: 10.1016/0065-2571(76)90016-9 |
0.53 |
|
| 1976 |
Nickon A, Lambert JL, Oliver JE, Covey DF, Morgan J. .beta.-Epimerization and .gamma.-hydrogen abstraction via homoenolate ions Journal of the American Chemical Society. 98: 2593-2599. DOI: 10.1021/Ja00425A031 |
0.595 |
|
| 1976 |
COVEY DF, ROBINSON CH. ChemInform Abstract: CONJUGATED ALLENIC 3-OXO-5,10-SECOSTEROIDS. IRREVERSIBLE INHIBITORS OF Δ5-3-KETOSTEROID ISOMERASE Chemischer Informationsdienst. 7: no-no. DOI: 10.1002/chin.197644355 |
0.508 |
|
| 1976 |
NICKON A, LAMBERT JL, OLIVER JE, COVEY DF, MORGAN J. ChemInform Abstract: β-EPIMERIZATION AND Γ-HYDROGEN ABSTRACTION VIA HOMOENOLATE IONS Chemischer Informationsdienst. 7: no-no. DOI: 10.1002/Chin.197628113 |
0.591 |
|
| 1975 |
Nickon A, Covey DF, Huang F, Kuo Y. Unusually facile bridgehead enolization. Locked boat forms in anti-Bredt olefins Journal of the American Chemical Society. 97: 904-905. DOI: 10.1021/Ja00837A043 |
0.592 |
|
| 1975 |
Nickon A, Covey DF, Pandit GD, Frank JJ. Regioselectivity and stereospecificity in homoketonizations. Control by thermodynamic and steric factors Tetrahedron Letters. 16: 3681-3684. DOI: 10.1016/S0040-4039(00)91307-8 |
0.542 |
|
| 1974 |
Nickon A, Frank JJ, Covey DF, Lin YI. Acid homoketonization with inversion of configuaration. Dramatic effect of water in control of stereochemistry Journal of the American Chemical Society. 96: 7574-7576. DOI: 10.1021/Ja00831A043 |
0.557 |
|
| 1973 |
HUNTER DH, JOHNSON AL, STOTHERS JB, NICKON A, LAMBERT JL, COVEY DF. ChemInform Abstract: (13)C-NMR-UNTERSUCHUNGEN 25. MITT. (13)C-NMR ZUR UEBERWACHUNG ANIONISCHER AUSTAUSCHPROZESSE, NICHT BENACHBARTE EPIMERISIERUNG UEBER HOMOENOLATIONEN UND ARYL-D-AUSTAUSCH Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197307129 |
0.602 |
|
| 1972 |
Hunter DH, Johnson AL, Stothers JB, Nickon A, Lambert JL, Covey DF. Carbon-13 nuclear magnetic resonance studies. XXV. Carbon-13 nuclear magnetic resonance as a monitor for anionic exchange processes. Remote epimerization via homoenolate ions and aryl D exchange Journal of the American Chemical Society. 94: 8582-8584. DOI: 10.1021/Ja00779A051 |
0.582 |
|
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