| Year |
Citation |
Score |
| 2024 |
Singhania M, Zaher A, Pulliam CF, Bayanbold K, Searby CC, Schoenfeld JD, Mapuskar KA, Fath MA, Allen BG, Spitz DR, Petronek MS. Quantitative MRI Evaluation of Ferritin Overexpression in Non-Small-Cell Lung Cancer. International Journal of Molecular Sciences. 25. PMID 38397073 DOI: 10.3390/ijms25042398 |
0.643 |
|
| 2024 |
Mapuskar KA, Pulliam CF, Tomanek-Chalkley A, Rastogi P, Wen H, Dayal S, Griffin BR, Zepeda-Orozco D, Sindler AL, Anderson CM, Beardsley R, Kennedy EP, Spitz DR, Allen BG. The antioxidant and anti-inflammatory activities of avasopasem manganese in age-associated, cisplatin-induced renal injury. Redox Biology. 70: 103022. PMID 38215546 DOI: 10.1016/j.redox.2023.103022 |
0.62 |
|
| 2023 |
Zaher A, Mapuskar KA, Sarkaria JN, Spitz DR, Petronek MS, Allen BG. Differential HO Metabolism among Glioblastoma Subtypes Confers Variable Responses to Pharmacological Ascorbate Therapy Combined with Chemoradiation. International Journal of Molecular Sciences. 24. PMID 38138986 DOI: 10.3390/ijms242417158 |
0.67 |
|
| 2023 |
Rauckhorst AJ, Martinez GV, Andrade GM, Wen H, Kim JY, Simoni A, Robles-Planells C, Mapuskar KA, Rastogi P, Steinbach EJ, McCormick ML, Allen BG, Pabla NS, Jackson AR, Coleman MC, ... Spitz DR, et al. Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury. Molecular Metabolism. 101849. PMID 38056691 DOI: 10.1016/j.molmet.2023.101849 |
0.722 |
|
| 2023 |
Bayanbold K, Singhania M, Fath MA, Searby CC, Stolwijk JM, Henrich JB, Pulliam CF, Schoenfeld JD, Mapuskar KA, Sho S, Caster JM, Allen BG, Buettner GR, Spies M, Goswami PC, ... ... Spitz DR, et al. Depletion of Labile Iron Induces Replication Stress and Enhances Responses to Chemoradiation in Non-Small-Cell Lung Cancer. Antioxidants (Basel, Switzerland). 12. PMID 38001858 DOI: 10.3390/antiox12112005 |
0.667 |
|
| 2023 |
Petronek MS, Monga V, Bodeker KL, Kwofie M, Lee CY, Mapuskar KA, Stolwijk JM, Zaher A, Wagner BA, Smith MC, Vollstedt S, Brown H, Chandler ML, Lorack AC, Wulfekuhle JS, ... ... Spitz DR, et al. Magnetic resonance imaging of iron metabolism with T2* mapping predicts an enhanced clinical response to pharmacological ascorbate in patients with GBM. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 37773633 DOI: 10.1158/1078-0432.CCR-22-3952 |
0.614 |
|
| 2023 |
Mapuskar KA, Pulliam CF, Zepeda-Orozco D, Griffin BR, Furqan M, Spitz DR, Allen BG. Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury. Antioxidants (Basel, Switzerland). 12. PMID 37760031 DOI: 10.3390/antiox12091728 |
0.668 |
|
| 2023 |
Solst SR, Mapuskar KA, Graham CH, King SA, Rheem R, Current K, Allen BG, Caster JM, Spitz DR, Howard ME. Rapid Peroxide Removal Limits the Radiosensitization of Diffuse Intrinsic Pontine Glioma (DIPG) Cells by Pharmacologic Ascorbate. Radiation Research. PMID 37758035 DOI: 10.1667/RADE-23-00006.1 |
0.649 |
|
| 2023 |
Rauckhorst AJ, Martinez GV, Andrade GM, Wen H, Kim JY, Simoni A, Mapuskar KA, Rastogi P, Steinbach EJ, McCormick ML, Allen BG, Pabla NS, Jackson AR, Coleman MC, Spitz DR, et al. Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury. Biorxiv : the Preprint Server For Biology. PMID 36778297 DOI: 10.1101/2023.01.31.526492 |
0.754 |
|
| 2022 |
Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo DF, ... ... Spitz DR, et al. Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes. Cell Metabolism. 34: 1893. PMID 36323238 DOI: 10.1016/j.cmet.2022.10.003 |
0.573 |
|
| 2022 |
Callaghan CM, Abukhiran IM, Masaadeh A, Van Rheeden RV, Kalen AL, Rodman SN, Petronek MS, Mapuskar KA, George BN, Coleman MC, Goswami PC, Allen BG, Spitz DR, Caster JM. Manipulation of Redox Metabolism using Pharmacologic Ascorbate Opens a Therapeutic Window for Radio-sensitization by ATM Inhibitors in Colorectal Cancer. International Journal of Radiation Oncology, Biology, Physics. PMID 36228747 DOI: 10.1016/j.ijrobp.2022.10.012 |
0.756 |
|
| 2022 |
O'Malley Y, Coleman MC, Sun X, Lei J, Yao J, Pulliam CF, Kluz P, McCormick ML, Yi Y, Imai Y, Engelhardt JF, Norris AW, Spitz DR, Uc A. Oxidative stress and impaired insulin secretion in cystic fibrosis pig pancreas. Advances in Redox Research : An Official Journal of the Society For Redox Biology and Medicine and the Society For Free Radical Research-Europe. 5. PMID 35903252 DOI: 10.1016/j.arres.2022.100040 |
0.573 |
|
| 2022 |
Byrne JD, Gallo D, Boyce H, Becker SL, Kezar KM, Cotoia AT, Feig VR, Lopes A, Csizmadia E, Longhi MS, Lee JS, Kim H, Wentworth AJ, Shankar S, Lee GR, ... ... Spitz DR, et al. Delivery of therapeutic carbon monoxide by gas-entrapping materials. Science Translational Medicine. 14: eabl4135. PMID 35767653 DOI: 10.1126/scitranslmed.abl4135 |
0.533 |
|
| 2021 |
Mehdi Z, Petronek MS, Stolwijk JM, Mapuskar KA, Kalen AL, Buettner GR, Cullen JJ, Spitz DR, Buatti JM, Allen BG. Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy. International Journal of Molecular Sciences. 22. PMID 34639220 DOI: 10.3390/ijms221910880 |
0.665 |
|
| 2021 |
Mapuskar KA, Steinbach EJ, Zaher A, Riley DP, Beardsley RA, Keene JL, Holmlund JT, Anderson CM, Zepeda-Orozco D, Buatti JM, Spitz DR, Allen BG. Mitochondrial Superoxide Dismutase in Cisplatin-Induced Kidney Injury. Antioxidants (Basel, Switzerland). 10. PMID 34572961 DOI: 10.3390/antiox10091329 |
0.641 |
|
| 2021 |
Ma DC, Anderson CM, Rodman SN, Buranasudja V, McCormick ML, Davis A, Loth E, Bodeker KL, Ahmann L, Parkhurst JR, Sun W, Follmer KR, Simons AL, Buatt JM, Spitz DR, et al. Ketogenic Diet with Concurrent Chemoradiation in Head and Neck Squamous Cell Carcinoma: Preclinical and Phase 1 Trial Results. Radiation Research. PMID 34087943 DOI: 10.1667/RADE-20-00150.1 |
0.528 |
|
| 2021 |
Carter CS, Huang S, Searby C, Cassaidy B, Miller M, Grzesik W, Piorczynski TB, Pak TK, Walsh S, Acevedo M, Zhang Q, Mapuskar K, Milne G, Hinton AO, Guo DF, ... ... Spitz DR, et al. Response to: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes. American Journal of Physiology. Endocrinology and Metabolism. PMID 33843283 DOI: 10.1152/ajpendo.00119.2021 |
0.579 |
|
| 2021 |
Carter CS, Huang S, Searby C, Cassaidy B, Miller M, Grzesik W, Piorczynski TB, Pak TK, Walsh S, Acevedo M, Zhang Q, Mapuskar K, Milne G, Hinton AO, Guo DF, ... ... Spitz DR, et al. Counterpoint regarding an alternative hypothesis for why exposure to static magnetic and electric fields treat type 2 diabetes. American Journal of Physiology. Endocrinology and Metabolism. PMID 33843282 DOI: 10.1152/ajpendo.00110.2021 |
0.575 |
|
| 2020 |
Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo DF, ... ... Spitz DR, et al. Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes. Cell Metabolism. 32: 1076. PMID 33264599 DOI: 10.1016/j.cmet.2020.11.001 |
0.573 |
|
| 2020 |
Cushing CM, Petronek MS, Bodeker KL, Vollstedt S, Brown HA, Opat E, Hollenbeck NJ, Shanks T, Berg DJ, Smith BJ, Smith MC, Monga V, Furqan M, Howard MA, Greenlee JD, ... ... Spitz DR, et al. Magnetic resonance imaging (MRI) of pharmacological ascorbate-induced iron redox state as a biomarker in subjects undergoing radio-chemotherapy. Redox Biology. 38: 101804. PMID 33260088 DOI: 10.1016/j.redox.2020.101804 |
0.601 |
|
| 2020 |
Rashmi R, Jayachandran K, Zhang J, Menon V, Muhammad N, Zahner M, Ruiz F, Zhang S, Cho K, Wang Y, Huang X, Huang Y, McCormick ML, Rogers BE, Spitz DR, et al. Glutaminase inhibitors induce thiol-mediated oxidative stress and radio-sensitization in treatment resistant cervical cancers. Molecular Cancer Therapeutics. PMID 33087507 DOI: 10.1158/1535-7163.MCT-20-0271 |
0.339 |
|
| 2020 |
Carter CS, Huang SC, Searby CC, Cassaidy B, Miller MJ, Grzesik WJ, Piorczynski TB, Pak TK, Walsh SA, Acevedo M, Zhang Q, Mapuskar KA, Milne GL, Hinton AO, Guo DF, ... ... Spitz DR, et al. Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes. Cell Metabolism. 32: 561-574.e7. PMID 33027675 DOI: 10.1016/j.cmet.2020.09.012 |
0.628 |
|
| 2020 |
Ubellacker JM, Tasdogan A, Ramesh V, Shen B, Mitchell EC, Martin-Sandoval MS, Gu Z, McCormick ML, Durham AB, Spitz DR, Zhao Z, Mathews TP, Morrison SJ. Lymph protects metastasizing melanoma cells from ferroptosis. Nature. PMID 32814895 DOI: 10.1038/S41586-020-2623-Z |
0.337 |
|
| 2020 |
Callaghan CM, Hasibuzzaman MM, Rodman SN, Goetz JE, Mapuskar KA, Petronek MS, Steinbach EJ, Miller BJ, Pulliam CF, Coleman MC, Monga VV, Milhem MM, Spitz DR, Allen BG. Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents. Cancers. 12. PMID 32806601 DOI: 10.3390/Cancers12082258 |
0.731 |
|
| 2020 |
Gibson AR, O'Leary BR, Du J, Sarsour EH, Kalen AL, Wagner BA, Stolwijk JM, Falls-Hubert KC, Alexander MS, Carroll RS, Spitz DR, Buettner GR, Goswami PC, Cullen JJ. Dual Oxidase-Induced Sustained Generation of Hydrogen Peroxide Contributes to Pharmacological Ascorbate-Induced Cytotoxicity. Cancer Research. PMID 32041838 DOI: 10.1158/0008-5472.Can-19-3094 |
0.413 |
|
| 2020 |
Seyedin SN, Hasibuzzaman MM, Pham V, Petronek MS, Callaghan C, Kalen AL, Mapuskar KA, Mott SL, Spitz DR, Allen BG, Caster JM. Combination therapy with radiation and PARP inhibition enhances responsiveness to anti-PD-1 therapy in colorectal tumor models. International Journal of Radiation Oncology, Biology, Physics. PMID 32036006 DOI: 10.1016/J.Ijrobp.2020.01.030 |
0.667 |
|
| 2020 |
Falls-Hubert KC, Butler AL, Gui K, Anderson M, Li M, Stolwijk JM, Rodman SN, Solst SR, Tomanek-Chalkley A, Searby CC, Sheffield VC, Sandfort V, Schmidt H, McCormick M, Wels BR, ... ... Spitz DR, et al. Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper. Free Radical Biology & Medicine. PMID 32032663 DOI: 10.1016/J.Freeradbiomed.2020.01.186 |
0.433 |
|
| 2019 |
Roy SJ, Koval OM, Sebag SC, Ait-Aissa K, Allen BG, Spitz DR, Grumbach IM. Inhibition of CaMKII in mitochondria preserves endothelial barrier function after irradiation. Free Radical Biology & Medicine. PMID 31711984 DOI: 10.1016/J.Freeradbiomed.2019.11.012 |
0.379 |
|
| 2019 |
Bi J, Yang S, Li L, Dai Q, Borcherding N, Wagner BA, Buettner GR, Spitz DR, Leslie KK, Zhang J, Meng X. Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death & Disease. 10: 682. PMID 31527591 DOI: 10.1038/S41419-019-1897-2 |
0.407 |
|
| 2019 |
Tompkins SC, Sheldon RD, Rauckhorst AJ, Noterman MF, Solst SR, Buchanan JL, Mapuskar KA, Pewa AD, Gray LR, Oonthonpan L, Sharma A, Scerbo DA, Dupuy AJ, Spitz DR, Taylor EB. Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis. Cell Reports. 28: 2608-2619.e6. PMID 31484072 DOI: 10.1016/J.Celrep.2019.07.098 |
0.652 |
|
| 2019 |
Bodeker KL, Allen BG, Smith MC, Monga V, Sandhu S, Hohl RJ, Carlisle TL, Brown HA, Hollenbeck NJ, Vollstedt S, Greenlee JDW, Howard MA, Mapuskar KA, Seyedin SN, Caster JM, ... ... Spitz DR, et al. First-in-human phase 1 clinical trial of pharmacological ascorbate combined with radiation and temozolomide for newly diagnosed glioblastoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31427282 DOI: 10.1158/1078-0432.Ccr-19-0594 |
0.648 |
|
| 2019 |
Petronek MS, Spitz DR, Buettner GR, Allen BG. Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism. Cancers. 11. PMID 31366108 DOI: 10.3390/Cancers11081077 |
0.335 |
|
| 2019 |
Spitz DR, Buettner GR, Petronek MS, St-Aubin JJ, Flynn RT, Waldron TJ, Limoli CL. An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. PMID 31010709 DOI: 10.1016/J.Radonc.2019.03.028 |
0.314 |
|
| 2019 |
Bittle J, Menezes EC, McCormick ML, Spitz DR, Dailey M, Stevens HE. The Role of Redox Dysregulation in the Effects of Prenatal Stress on Embryonic Interneuron Migration. Cerebral Cortex (New York, N.Y. : 1991). PMID 30877797 DOI: 10.1093/Cercor/Bhz052 |
0.346 |
|
| 2019 |
Mapuskar KA, Anderson CM, Spitz DR, Batinic-Haberle I, Allen BG, E Oberley-Deegan R. Utilizing Superoxide Dismutase Mimetics to Enhance Radiation Therapy Response While Protecting Normal Tissues. Seminars in Radiation Oncology. 29: 72-80. PMID 30573187 DOI: 10.1016/J.Semradonc.2018.10.005 |
0.7 |
|
| 2019 |
Schoenfeld JD, Alexander MS, Waldron TJ, Sibenaller ZA, Spitz DR, Buettner GR, Allen BG, Cullen JJ. Pharmacological Ascorbate as a Means of Sensitizing Cancer Cells to Radio-Chemotherapy While Protecting Normal Tissue. Seminars in Radiation Oncology. 29: 25-32. PMID 30573181 DOI: 10.1016/J.Semradonc.2018.10.006 |
0.389 |
|
| 2019 |
Spitz DR. Manipulations of Redox Metabolism for Enhancing Radiation Therapy Responses: A Historical Perspective and Novel Hypothesis. Seminars in Radiation Oncology. 29: 1-5. PMID 30573179 DOI: 10.1016/J.Semradonc.2018.10.010 |
0.312 |
|
| 2018 |
Mapuskar KA, Wen H, Holanda DG, Rastogi P, Steinbach E, Han R, Coleman MC, Attanasio M, Riley DP, Spitz DR, Allen BG, Zepeda-Orozco D. Persistent increase in mitochondrial superoxide mediates cisplatin-induced chronic kidney disease. Redox Biology. 20: 98-106. PMID 30296702 DOI: 10.1016/J.Redox.2018.09.020 |
0.761 |
|
| 2018 |
Alexander MS, Wilkes JG, Schroeder SR, Buettner GR, Wagner BA, Du J, Gibson-Corely K, O'Leary BR, Spitz DR, Buatti JM, Berg DJ, Bodeker KL, Vollstedt S, Brown HA, Allen BG, et al. Pharmacological ascorbate reduces radiation-induced normal tissue toxicity and enhances tumor radiosensitization in pancreatic cancer. Cancer Research. PMID 30254147 DOI: 10.1158/0008-5472.Can-18-1680 |
0.383 |
|
| 2018 |
Zhu Y, Dean AE, Horikoshi N, Heer C, Spitz DR, Gius D. Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy. The Journal of Clinical Investigation. 128: 3682-3691. PMID 30168803 DOI: 10.1172/Jci120844 |
0.592 |
|
| 2018 |
Luo M, Shang L, Brooks MD, Jiagge E, Zhu Y, Buschhaus JM, Conley S, Fath MA, Davis A, Gheordunescu E, Wang Y, Harouaka R, Lozier A, Triner D, McDermott S, ... ... Spitz DR, et al. Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling. Cell Metabolism. 28: 69-86.e6. PMID 29972798 DOI: 10.1016/J.Cmet.2018.06.006 |
0.4 |
|
| 2018 |
Brandt KE, Falls KC, Schoenfeld JD, Rodman SN, Gu Z, Zhan F, Cullen JJ, Wagner BA, Buettner GR, Allen BG, Berg DJ, Spitz DR, Fath MA. Corrigendum to: Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells [Redox Biol. (2018) 82-87]. Redox Biology. PMID 29891355 DOI: 10.1016/J.Redox.2018.06.001 |
0.302 |
|
| 2018 |
Pennington SM, Klutho PR, Xie L, Broadhurst K, Koval OM, McCormick ML, Spitz DR, Grumbach IM. Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription. Redox Biology. 16: 401-413. PMID 29649787 DOI: 10.1016/J.Redox.2018.04.001 |
0.36 |
|
| 2018 |
O'Leary BR, Houwen FK, Johnson CL, Allen BG, Mezhir JJ, Berg DJ, Cullen JJ, Spitz DR. Pharmacological Ascorbate as an Adjuvant for Enhancing Radiation-Chemotherapy Responses in Gastric Adenocarcinoma. Radiation Research. PMID 29547353 DOI: 10.1667/Rr14978.1 |
0.32 |
|
| 2018 |
Zhang X, Yoon JY, Morley M, McLendon JM, Mapuskar KA, Gutmann R, Mehdi H, Bloom HL, Dudley SC, Ellinor PT, Shalaby AA, Weiss R, Tang WHW, Moravec CS, Singh M, ... ... Spitz DR, et al. A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality. The Journal of Clinical Investigation. PMID 29457789 DOI: 10.1172/Jci95710 |
0.609 |
|
| 2018 |
Heer CD, Davis AB, Riffe DB, Wagner BA, Falls KC, Allen BG, Buettner GR, Beardsley RA, Riley DP, Spitz DR. Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner. Antioxidants (Basel, Switzerland). 7. PMID 29351198 DOI: 10.3390/Antiox7010018 |
0.453 |
|
| 2018 |
Rashmi R, Huang X, Floberg JM, Elhammali A, McCormick ML, Patti GJ, Spitz DR, Schwarz JK. Radio-resistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism. Cancer Research. PMID 29339540 DOI: 10.1158/0008-5472.Can-17-2367 |
0.425 |
|
| 2018 |
Ma D, Anderson C, Rodmann SN, Follmer K, Buranasudja V, Bodeker K, Parkhurst JR, McCormack M, Davis A, Spitz DR, Buatti J, Allen BG, Fath MA. Abstract LB-252: Ketogenic diet with concurrent chemoradiation in head and neck squamous cell carcinoma: Pre-clinical and phase I trial results Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Lb-252 |
0.4 |
|
| 2018 |
Sishc BJ, Polsdofer E, Bloom DA, Heer C, Spitz DR, Saha D, Story MD. Abstract 667: The radioprotector GC4419 ameliorates radiation induced lung fibrosis while enhancing the response of non-small cell lung cancer tumors to high dose per fraction radiation exposures Cancer Research. 78: 667-667. DOI: 10.1158/1538-7445.Am2018-667 |
0.354 |
|
| 2018 |
Sciegienka S, Rodman S, Tomanek-Chalkley A, Falls KC, Spitz DR, Fath MA. Abstract 3219: Sensitizing hypoxic small cell lung cancer cells to radiation and hydrogen peroxide-producing agents using CuATSM Tumor Biology. DOI: 10.1158/1538-7445.Am2018-3219 |
0.367 |
|
| 2018 |
Mohanty AJ, Sishc BJ, Falls KC, Heer CD, Spitz DR, Story MD. Abstract 2929: GC4419 enhances the response of non-small cell lung carcinoma cell lines to cisplatin and cisplatin plus radiation through a ROS-mediated pathway Cancer Research. 78: 2929-2929. DOI: 10.1158/1538-7445.Am2018-2929 |
0.424 |
|
| 2018 |
Story M, Sishc B, Polsdofer E, Bloom D, Heer C, Spitz D, Saha D. The Radioprotector GC4419 Ameliorates Radiation Induced Lung Fibrosis While Enhancing the Response of Non-Small Cell Lung Cancer Tumors to High Dose per Fraction Radiation Exposures International Journal of Radiation Oncology*Biology*Physics. 102: S187. DOI: 10.1016/J.Ijrobp.2018.07.071 |
0.329 |
|
| 2017 |
Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Bradley MD, Wagner BA, Buettner GR, Monga V, Milhem M, Spitz DR, Allen BG. Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models. Redox Biology. 14: 417-422. PMID 29069637 DOI: 10.1016/J.Redox.2017.09.012 |
0.701 |
|
| 2017 |
Brandt KE, Falls KC, Schoenfeld JD, Rodman SN, Gu Z, Zhan F, Cullen JJ, Wagner BA, Buettner GR, Allen BG, Berg DJ, Spitz DR, Fath MA. Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells. Redox Biology. 14: 82-87. PMID 28886484 DOI: 10.1016/J.Redox.2017.08.017 |
0.352 |
|
| 2017 |
Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, Sandhu S, Carlisle TL, Smith MC, Abu Hejleh T, Berg DJ, Zhang J, Keech J, Parekh KR, Bhatia S, ... ... Spitz DR, et al. O2(⋅-) and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer Cell. 32: 268. PMID 28810149 DOI: 10.1016/J.Ccell.2017.07.008 |
0.679 |
|
| 2017 |
Mapuskar KA, Flippo KH, Schoenfeld JD, Riley DP, Strack S, Abu-Hejleh T, Furqan M, Monga V, Domann FE, Buatti JM, Goswami PC, Spitz DR, Allen BG. Mitochondrial superoxide increases age-associated susceptibility of human dermal fibroblasts to radiation and chemotherapy. Cancer Research. PMID 28765155 DOI: 10.1158/0008-5472.Can-17-0106 |
0.695 |
|
| 2017 |
Zahra A, Fath MA, Opat E, Mapuskar KA, Bhatia SK, Ma DC, Iii SNR, Snyders TP, Chenard CA, Eichenberger-Gilmore JM, Bodeker KL, Ahmann L, Smith BJ, Vollstedt SA, Brown HA, ... ... Spitz DR, et al. Consuming a Ketogenic Diet while Receiving Radiation and Chemotherapy for Locally Advanced Lung Cancer and Pancreatic Cancer: The University of Iowa Experience of Two Phase 1 Clinical Trials. Radiation Research. PMID 28437190 DOI: 10.1667/Rr14668.1 |
0.702 |
|
| 2017 |
Sciegienka SJ, Solst SR, Falls KC, Schoenfeld JD, Klinger AR, Ross NL, Rodman SN, Spitz DR, Fath MA. D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H2O2-mediated oxidative stress. Free Radical Biology & Medicine. PMID 28389407 DOI: 10.1016/J.Freeradbiomed.2017.04.001 |
0.451 |
|
| 2017 |
Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, Sandhu S, Carlisle TL, Smith MC, Abu Hejleh T, Berg DJ, Zhang J, Keech J, Parekh KR, Bhatia S, ... ... Spitz DR, et al. O2(⋅-) and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer Cell. PMID 28366679 DOI: 10.1016/J.Ccell.2017.02.018 |
0.725 |
|
| 2017 |
Luo M, Shang L, Brooks M, Jiagge E, Conley S, Harouaka R, Zhu Y, Merajver SD, Spitz DR, Wicha MS. Abstract 4785: Disrupting redox regulated cancer stem cell state equilibrium by co-inhibition of glycolysis and thioredoxin/glutathione antioxidant pathways Cancer Research. 77: 4785-4785. DOI: 10.1158/1538-7445.Am2017-4785 |
0.373 |
|
| 2017 |
Spitz D. Targeting Redox Metabolism For Cancer Therapy: From The Bench To The Bedside Free Radical Biology and Medicine. 112: 12. DOI: 10.1016/J.Freeradbiomed.2017.10.363 |
0.423 |
|
| 2017 |
Solst SR, Rodman SN, Fath MA, Taylor EB, Spitz DR. Inhibition of Mitochondrial Pyruvate Transport Selectively Sensitizes Cancer Cells to Metabolic Oxidative Stress Free Radical Biology and Medicine. 112: 102. DOI: 10.1016/J.Freeradbiomed.2017.10.154 |
0.467 |
|
| 2017 |
Heer CD, Davis AB, Riffe DB, Wagner BA, Falls KC, Buettner GR, Beardsley RA, Riley DP, Allen BG, Spitz DR. Penta-azamacrocyclic SOD Mimetics Enhance Pharmacological Ascorbate Oxidation and Anticancer effects in an H 2 O 2 -dependent Manner Free Radical Biology and Medicine. 112: 90-91. DOI: 10.1016/J.Freeradbiomed.2017.10.132 |
0.418 |
|
| 2017 |
Falls K, Gui K, Anderson M, Rodman S, Solst S, Fath M, McCormick M, Spitz D. Disulfiram causes Selective Hypoxic Cancer Cell Toxicity and Radio-chemo-sensitization via Redox Cycling of Copper and O 2 •‒ mediated Oxidative Stress Free Radical Biology and Medicine. 112: 88. DOI: 10.1016/J.Freeradbiomed.2017.10.128 |
0.403 |
|
| 2016 |
Schibler J, Tomanek-Chalkley AM, Reedy JL, Zhan F, Spitz DR, Schultz MK, Goel A. Mitochondrial-Targeted Decyl-Triphenylphosphonium Enhances 2-Deoxy-D-Glucose Mediated Oxidative Stress and Clonogenic Killing of Multiple Myeloma Cells. Plos One. 11: e0167323. PMID 27902770 DOI: 10.1371/Journal.Pone.0167323 |
0.442 |
|
| 2016 |
Allen BG, Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Furqan M, Abu Hejleh T, Wagner B, Cullen JJ, Buettner GR, Buatti J, Spitz D. Pharmacological Ascorbate Enhances the Response of Non-Small Cell Lung Cancer (NSCLC) to Radiation and Chemotherapy Via Disruptions of Redox Active Iron Leading to Increased H2O2. International Journal of Radiation Oncology, Biology, Physics. 96: S239. PMID 27675877 DOI: 10.1016/J.Ijrobp.2016.06.594 |
0.682 |
|
| 2016 |
Rodman SN, Spence JM, Ronnfeldt TJ, Zhu Y, Solst SR, O'Neill RA, Allen BG, Guan X, Spitz DR, Fath MA. Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism. Radiation Research. PMID 27643875 DOI: 10.1667/Rr14463.1 |
0.61 |
|
| 2016 |
Wongrakpanich A, Mudunkotuwa IA, Geary SM, Morris AS, Mapuskar KA, Spitz DR, Grassian VH, Salem AK. Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells. Environmental Science. Nano. 3: 365-374. PMID 27347420 DOI: 10.1039/C5En00271K |
0.646 |
|
| 2016 |
Wongrakpanich A, Mudunkotuwa IA, Geary SM, Morris AS, Mapuskar KA, Spitz DR, Grassian VH, Salem AK. Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells Environmental Science: Nano. 3: 365-374. DOI: 10.1039/c5en00271k |
0.616 |
|
| 2016 |
Anderson C, Loth E, Opat E, Bodeker K, Ahmann L, Parkhurst J, Sun W, Furqan M, Laux D, Brown H, Vollstedt S, Follmer K, Ma D, Spitz D, Fath M, et al. A Phase 1 Trial of Ketogenic Diet With Concurrent Chemoradiation (CRT) in Head and Neck Squamous Cell Carcinoma (HNSCC) International Journal of Radiation Oncology*Biology*Physics. 94: 898. DOI: 10.1016/J.Ijrobp.2015.12.104 |
0.478 |
|
| 2016 |
Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner B, Miller B, Monga V, Milhem M, Spitz DR, Allen BG. Pharmacological Ascorbate in Combination with Standard-Of-Care Radio-Chemotherapy Enhances Tumor Response in an Orthotopic Sarcoma Model Free Radical Biology and Medicine. 100: S193-S194. DOI: 10.1016/J.Freeradbiomed.2016.10.529 |
0.65 |
|
| 2015 |
Silvis AM, McCormick ML, Spitz DR, Kiningham KK. Redox balance influences differentiation status of neuroblastoma in the presence of all-trans retinoic acid. Redox Biology. 7: 88-96. PMID 26678800 DOI: 10.1016/J.Redox.2015.11.012 |
0.418 |
|
| 2015 |
Rasmussen TP, Wu Y, Joiner ML, Koval OM, Wilson NR, Luczak ED, Wang Q, Chen B, Gao Z, Zhu Z, Wagner BA, Soto J, McCormick ML, Kutschke W, Weiss RM, ... ... Spitz DR, et al. Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart. Proceedings of the National Academy of Sciences of the United States of America. 112: 9129-34. PMID 26153425 DOI: 10.1073/Pnas.1504705112 |
0.303 |
|
| 2015 |
Hrabe JE, O'Leary BR, Fath MA, Rodman SN, Button AM, Domann FE, Spitz DR, Mezhir JJ. Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells. Redox Biology. 5: 319-327. PMID 26114584 DOI: 10.1016/J.Redox.2015.06.004 |
0.454 |
|
| 2015 |
Du J, Cieslak JA, Welsh JL, Sibenaller ZA, Allen BG, Wagner BA, Kalen AL, Doskey CM, Strother RK, Button AM, Mott SL, Smith B, Tsai S, Mezhir J, Goswami PC, ... Spitz DR, et al. Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer. Cancer Research. PMID 26081808 DOI: 10.1158/0008-5472.Can-14-1707 |
0.457 |
|
| 2015 |
Bayer JL, Spitz DR, Christensen D, McCormick ML, Farley D, DeGeest K, Damoush L, Aust S, Sood AK, Lutgendorf SK. Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma. Brain, Behavior, and Immunity. PMID 25989110 DOI: 10.1016/J.Bbi.2015.04.019 |
0.366 |
|
| 2015 |
O'Leary BR, Fath MA, Bellizzi AM, Hrabe JE, Button AM, Allen BG, Case AJ, Altekruse S, Wagner BA, Buettner GR, Lynch CF, Hernandez BY, Cozen W, Beardsley RA, Keene J, ... ... Spitz DR, et al. Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 1741-51. PMID 25634994 DOI: 10.1158/1078-0432.Ccr-14-1959 |
0.348 |
|
| 2015 |
Li L, Fath MA, Scarbrough PM, Watson WH, Spitz DR. Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer. Redox Biology. 4: 127-35. PMID 25560241 DOI: 10.1016/J.Redox.2014.12.001 |
0.816 |
|
| 2015 |
Mezhir JJ, O'Leary BR, Bellizzi AM, Altekruse S, Lynch CF, Hernandez BY, Cozen W, Henry MD, Keene J, Beardsley RA, Spitz DR, Domann FE. Abstract B52: The role of extracellular superoxide dismutase activity in pancreatic cancer biology and therapy Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-B52 |
0.397 |
|
| 2015 |
Luo M, Davis A, McDermott S, Jiagge E, Brooks M, Gheordunescu E, Luther T, Clouthier SG, Conley S, Spitz DR, Wicha MS. Abstract 2311: Targeting EMT and MET breast cancer stem cell states through simultaneous inhibition of glycolytic and antioxidant pathways Cancer Research. 75: 2311-2311. DOI: 10.1158/1538-7445.Am2015-2311 |
0.412 |
|
| 2015 |
Ma DC, Rodman SN, Buatti JM, Anderson C, Allen BG, Spitz DR, Fath MA. Abstract 1177: Ketogenic diet sensitizes FaDu human head and neck cancer xenografts to cisplatin as well as ionizing radiation combined with cetuximab Cancer Research. 75: 1177-1177. DOI: 10.1158/1538-7445.Am2015-1177 |
0.399 |
|
| 2015 |
Salinas E, Wernimont S, Mapuskar K, Szweda L, McCormick M, Spitz D, Goodheart M. Oxidative stress biomarkers and risk of endometrial cancer Gynecologic Oncology. 137: 160. DOI: 10.1016/J.Ygyno.2015.01.401 |
0.679 |
|
| 2015 |
Mitchell D, Buchakjian M, DeZwaan D, Wagner B, Spitz D, Rutkowski T, Henry M. Targeting a Metabolic Phenotype in EMT-like Prostate Cancer Cells to Improve Radiation Therapy International Journal of Radiation Oncology*Biology*Physics. 93: E516. DOI: 10.1016/J.Ijrobp.2015.07.1867 |
0.338 |
|
| 2015 |
Mapuskar KA, Schoenfeld JD, Sibenaller ZA, Riley DP, Strack S, Goswami PC, Buatti JM, Spitz DR, Allen BG. Increased DNA Damage and Reactive Oxygen Species Mediate Age-Associated Differential Susceptibility of Normal Dermal Fibroblasts to Chemotherapy and Radiation Free Radical Biology and Medicine. 87: S130-S131. DOI: 10.1016/J.Freeradbiomed.2015.10.340 |
0.654 |
|
| 2015 |
Schoenfeld JD, Sibenaller ZA, Doskey CM, Mapuskar KA, Parekh KR, Keech JC, Cullen JJ, Buettner GR, Spitz DR, Allen BG. The Selective Toxicity of Pharmacological Ascorbate Is Mediated by Alterations in Iron Metabolism Free Radical Biology and Medicine. 87: S72-S73. DOI: 10.1016/J.Freeradbiomed.2015.10.191 |
0.64 |
|
| 2014 |
Allen BG, Bhatia SK, Anderson CM, Eichenberger-Gilmore JM, Sibenaller ZA, Mapuskar KA, Schoenfeld JD, Buatti JM, Spitz DR, Fath MA. Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism. Redox Biology. 2: 963-970. PMID 25460731 DOI: 10.1016/J.Redox.2014.08.002 |
0.732 |
|
| 2014 |
Wegman-Points LJ, Teoh-Fitzgerald ML, Mao G, Zhu Y, Fath MA, Spitz DR, Domann FE. Retroviral-infection increases tumorigenic potential of MDA-MB-231 breast carcinoma cells by expanding an aldehyde dehydrogenase (ALDH1) positive stem-cell like population. Redox Biology. 2: 847-54. PMID 25009786 DOI: 10.1016/J.Redox.2014.06.006 |
0.707 |
|
| 2014 |
Zhou D, Shao L, Spitz DR. Reactive oxygen species in normal and tumor stem cells. Advances in Cancer Research. 122: 1-67. PMID 24974178 DOI: 10.1016/B978-0-12-420117-0.00001-3 |
0.333 |
|
| 2014 |
Hall DD, Wu Y, Domann FE, Spitz DR, Anderson ME. Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival. Plos One. 9: e96866. PMID 24802861 DOI: 10.1371/Journal.Pone.0096866 |
0.425 |
|
| 2014 |
Wongrakpanich A, Adamcakova-Dodd A, Xie W, Joshi VB, Mapuskar KA, Geary SM, Spitz DR, Thorne PS, Salem AK. The absence of CpG in plasmid DNA-chitosan polyplexes enhances transfection efficiencies and reduces inflammatory responses in murine lungs. Molecular Pharmaceutics. 11: 1022-31. PMID 24494979 DOI: 10.1021/Mp400689R |
0.655 |
|
| 2014 |
Spitz DR, Hauer-Jensen M. Ionizing radiation-induced responses: where free radical chemistry meets redox biology and medicine. Antioxidants & Redox Signaling. 20: 1407-9. PMID 24354361 DOI: 10.1089/Ars.2013.5769 |
0.351 |
|
| 2014 |
Coleman MC, Olivier AK, Jacobus JA, Mapuskar KA, Mao G, Martin SM, Riley DP, Gius D, Spitz DR. Superoxide mediates acute liver injury in irradiated mice lacking sirtuin 3. Antioxidants & Redox Signaling. 20: 1423-35. PMID 23919724 DOI: 10.1089/Ars.2012.5091 |
0.776 |
|
| 2014 |
Mapuskar KA, Schoenfeld JD, Sibenaller ZA, Buettner GR, Domann FE, Spitz DR, Allen BG. Superoxide Mediates Alterations in Complex I Activity Seen in Adult Versus Neonatal Fibroblasts Free Radical Biology and Medicine. 76: S34-S35. DOI: 10.1016/J.Freeradbiomed.2014.10.451 |
0.624 |
|
| 2014 |
Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Cullen JJ, Buettner GR, Spitz DR, Allen BG. Intracellular Redox Active Metal Ions Mediate the Differential Susceptibility of Lung and Brain Cancer Cells to Pharmacological Ascorbate Free Radical Biology and Medicine. 76: S131. DOI: 10.1016/J.Freeradbiomed.2014.10.210 |
0.654 |
|
| 2014 |
Kloepping KC, Kraus AS, Hedlund DK, Gnade CM, Fath MA, Coleman MC, Wagner BA, Mapuskar KA, Spitz DR, Schultz MK. Triphenylphosphonium Derivative-Based Combination Therapy for Metastatic Melanoma Free Radical Biology and Medicine. 76: S128. DOI: 10.1016/J.Freeradbiomed.2014.10.200 |
0.714 |
|
| 2013 |
Cyr AR, Brown KE, McCormick ML, Coleman MC, Case AJ, Watts GS, Futscher BW, Spitz DR, Domann FE. Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes. Redox Biology. 1: 172-7. PMID 24024150 DOI: 10.1016/J.Redox.2013.01.001 |
0.621 |
|
| 2013 |
Worthington KL, Adamcakova-Dodd A, Wongrakpanich A, Mudunkotuwa IA, Mapuskar KA, Joshi VB, Allan Guymon C, Spitz DR, Grassian VH, Thorne PS, Salem AK. Chitosan coating of copper nanoparticles reduces in vitro toxicity and increases inflammation in the lung. Nanotechnology. 24: 395101. PMID 24008224 DOI: 10.1088/0957-4484/24/39/395101 |
0.635 |
|
| 2013 |
Zhu Y, Mapuskar KA, Marek RF, Xu W, Lehmler HJ, Robertson LW, Hornbuckle KC, Spitz DR, Aykin-Burns N. A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11). Toxicological Sciences : An Official Journal of the Society of Toxicology. 136: 39-50. PMID 23997111 DOI: 10.1093/Toxsci/Kft186 |
0.763 |
|
| 2013 |
Bey EA, Reinicke KE, Srougi MC, Varnes M, Anderson VE, Pink JJ, Li LS, Patel M, Cao L, Moore Z, Rommel A, Boatman M, Lewis C, Euhus DM, Bornmann WG, ... ... Spitz DR, et al. Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers Molecular Cancer Therapeutics. 12: 2110-2120. PMID 23883585 DOI: 10.1158/1535-7163.Mct-12-0962 |
0.408 |
|
| 2013 |
Jacobus JA, Duda CG, Coleman MC, Martin SM, Mapuskar K, Mao G, Smith BJ, Aykin-Burns N, Guida P, Gius D, Domann FE, Knudson CM, Spitz DR. Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender. Radiation Research. 180: 156-65. PMID 23819597 DOI: 10.1667/Rr3293.1 |
0.79 |
|
| 2013 |
Xiao W, Zhu Y, Sarsour EH, Kalen AL, Aykin-Burns N, Spitz DR, Goswami PC. Selenoprotein P regulates 1-(4-Chlorophenyl)-benzo-2,5-quinone-induced oxidative stress and toxicity in human keratinocytes. Free Radical Biology & Medicine. 65: 70-7. PMID 23770201 DOI: 10.1016/J.Freeradbiomed.2013.06.010 |
0.616 |
|
| 2013 |
Allen BG, Bhatia SK, Buatti JM, Brandt KE, Lindholm KE, Button AM, Szweda LI, Smith BJ, Spitz DR, Fath MA. Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 3905-13. PMID 23743570 DOI: 10.1158/1078-0432.Ccr-12-0287 |
0.434 |
|
| 2013 |
Conley SJ, Baker T, Theisen R, Gheordunescu E, Zhu Y, Aykin-Burns N, Fath M, Spitz D, Wicha M. Abstract 3729: Targeting breast cancer stem cells via oxidative stress with inhibitors of hydroperoxide metabolism and decyl-triphenylphosphonium. Cancer Research. 73: 3729-3729. DOI: 10.1158/1538-7445.Am2013-3729 |
0.62 |
|
| 2013 |
Hrabe J, Domann F, Spitz D, Mezhir J. Inhibition of TAK1 Decreases Colon Cancer Cell Survival by Thiol-dependent Oxidative Stress Journal of Surgical Research. 179: 250. DOI: 10.1016/J.Jss.2012.10.471 |
0.428 |
|
| 2013 |
Xiao W, Zhu Y, Sarsour EH, Kalen AL, Aykin-Burns N, Spitz DR, Goswami PC. Selenoprotein P Regulates Environmental Pollutant PCB-Induced Oxidative Stress and Toxicity in Human Keratinocytes Free Radical Biology and Medicine. 65: S136. DOI: 10.1016/J.Freeradbiomed.2013.10.740 |
0.355 |
|
| 2012 |
Kim SY, Rhee JG, Song X, Prochownik EV, Spitz DR, Lee YJ. Breast cancer stem cell-like cells are more sensitive to ionizing radiation than non-stem cells: role of ATM. Plos One. 7: e50423. PMID 23185620 DOI: 10.1371/Journal.Pone.0050423 |
0.36 |
|
| 2012 |
Sobhakumari A, Love-Homan L, Fletcher EV, Martin SM, Parsons AD, Spitz DR, Knudson CM, Simons AL. Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism. Plos One. 7: e48175. PMID 23118946 DOI: 10.1371/Journal.Pone.0048175 |
0.467 |
|
| 2012 |
Duru N, Fan M, Candas D, Menaa C, Liu HC, Nantajit D, Wen Y, Xiao K, Eldridge A, Chromy BA, Li S, Spitz DR, Lam KS, Wicha MS, Li JJ. HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 6634-47. PMID 23091114 DOI: 10.1158/1078-0432.Ccr-12-1436 |
0.318 |
|
| 2012 |
Zhu Y, Park SH, Ozden O, Kim HS, Jiang H, Vassilopoulos A, Spitz DR, Gius D. Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity. Free Radical Biology & Medicine. 53: 828-33. PMID 22732184 DOI: 10.1016/J.Freeradbiomed.2012.06.020 |
0.559 |
|
| 2012 |
Tyra HM, Spitz DR, Rutkowski DT. Inhibition of fatty acid oxidation enhances oxidative protein folding and protects hepatocytes from endoplasmic reticulum stress. Molecular Biology of the Cell. 23: 811-9. PMID 22262455 DOI: 10.1091/Mbc.E11-12-1011 |
0.373 |
|
| 2012 |
Osborn-Heaford HL, Ryan AJ, Murthy S, Racila AM, He C, Sieren JC, Spitz DR, Carter AB. Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis. The Journal of Biological Chemistry. 287: 3301-12. PMID 22157762 DOI: 10.1074/Jbc.M111.308387 |
0.31 |
|
| 2012 |
Scarbrough PM, Mapuskar KA, Mattson DM, Gius D, Watson WH, Spitz DR. Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress. Free Radical Biology & Medicine. 52: 436-43. PMID 22100505 DOI: 10.1016/J.Freeradbiomed.2011.10.493 |
0.828 |
|
| 2012 |
Owens KM, Aykin-Burns N, Dayal D, Coleman MC, Domann FE, Spitz DR. Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2. Free Radical Biology & Medicine. 52: 160-6. PMID 22041456 DOI: 10.1016/J.Freeradbiomed.2011.10.435 |
0.777 |
|
| 2012 |
Zagorodna O, Martin SM, Rutkowski DT, Kuwana T, Spitz DR, Knudson CM. 2-deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines. Oncogene. 31: 2738-49. PMID 21986940 DOI: 10.1038/Onc.2011.454 |
0.399 |
|
| 2012 |
Goel A, Spitz DR, Weiner GJ. Manipulation of cellular redox parameters for improving therapeutic responses in B-cell lymphoma and multiple myeloma. Journal of Cellular Biochemistry. 113: 419-25. PMID 21956712 DOI: 10.1002/Jcb.23387 |
0.409 |
|
| 2012 |
Candas D, Fan M, Duru N, Menaa C, Wen Y, Xiao K, Eldridge A, Chromy BA, Li S, Spitz DR, Lam KS, Max MS, Li JJ. Abstract 5724: HER2-mediated resistance of breast cancer stem cells in HER2-negative/low breast cancer Cancer Research. 72: 5724-5724. DOI: 10.1158/1538-7445.Am2012-5724 |
0.364 |
|
| 2012 |
Rodman SN, Zhu Y, Ronnfeldt TJ, Wilke WW, Allen BG, Spitz DR, Fath MA. Abstract 1470: Enhancing radiation therapy by simultaneous inhibition of thioredoxin- and glutathione-dependent metabolism Cancer Research. 72: 1470-1470. DOI: 10.1158/1538-7445.Am2012-1470 |
0.642 |
|
| 2012 |
Kloepping KC, Coleman MC, Wagner BA, Jacobus JA, Mapuskar KA, Buettner GR, Spitz DR, Schultz MK. Small Molecule Oxidative Metabolism Inhibitors for Metastatic Melanoma Therapy Free Radical Biology and Medicine. 53: S46. DOI: 10.1016/J.Freeradbiomed.2012.10.121 |
0.744 |
|
| 2012 |
Bayer-Carter JL, Christensen D, Dahmoush L, McCormick ML, DeGeest K, Spitz DR, Sood A, Lutgendorf SK. 122. Psychological risk factors are related to higher levels of antioxidant enzyme activity in ovarian cancer patients Brain Behavior and Immunity. 26. DOI: 10.1016/J.Bbi.2012.07.146 |
0.362 |
|
| 2011 |
He BJ, Joiner ML, Singh MV, Luczak ED, Swaminathan PD, Koval OM, Kutschke W, Allamargot C, Yang J, Guan X, Zimmerman K, Grumbach IM, Weiss RM, Spitz DR, Sigmund CD, et al. Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nature Medicine. 17: 1610-8. PMID 22081025 DOI: 10.1038/Nm.2506 |
0.304 |
|
| 2011 |
Park SH, Ozden O, Jiang H, Cha YI, Pennington JD, Aykin-Burns N, Spitz DR, Gius D, Kim HS. Sirt3, mitochondrial ROS, ageing, and carcinogenesis. International Journal of Molecular Sciences. 12: 6226-39. PMID 22016654 DOI: 10.3390/Ijms12096226 |
0.354 |
|
| 2011 |
Fath MA, Ahmad IM, Smith CJ, Spence J, Spitz DR. Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 6206-17. PMID 21844013 DOI: 10.1158/1078-0432.Ccr-11-0736 |
0.719 |
|
| 2011 |
Schickling BM, Aykin-Burns N, Leslie KK, Spitz DR, Korovkina VP. An inhibitor of K+ channels modulates human endometrial tumor-initiating cells. Cancer Cell International. 11: 25. PMID 21810252 DOI: 10.1186/1475-2867-11-25 |
0.319 |
|
| 2011 |
Spitz DR. Metabolic oxidative stress and low dose radiation responses: are mitochondria involved. Health Physics. 100: 295. PMID 21595073 DOI: 10.1097/Hp.0B013E31820840Aa |
0.377 |
|
| 2011 |
Orcutt KP, Parsons AD, Sibenaller ZA, Scarbrough PM, Zhu Y, Sobhakumari A, Wilke WW, Kalen AL, Goswami P, Miller FJ, Spitz DR, Simons AL. Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4. Cancer Research. 71: 3932-40. PMID 21482679 DOI: 10.1158/0008-5472.Can-10-3425 |
0.816 |
|
| 2011 |
Ozden O, Park SH, Kim HS, Jiang H, Coleman MC, Spitz DR, Gius D. Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress. Aging. 3: 102-7. PMID 21386137 |
0.591 |
|
| 2011 |
Aykin-Burns N, Slane BG, Liu AT, Owens KM, O'Malley MS, Smith BJ, Domann FE, Spitz DR. Sensitivity to low-dose/low-LET ionizing radiation in mammalian cells harboring mutations in succinate dehydrogenase subunit C is governed by mitochondria-derived reactive oxygen species. Radiation Research. 175: 150-8. PMID 21268708 DOI: 10.1667/Rr2220.1 |
0.751 |
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| 2011 |
Case AJ, McGill JL, Tygrett LT, Shirasawa T, Spitz DR, Waldschmidt TJ, Legge KL, Domann FE. Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge. Free Radical Biology & Medicine. 50: 448-58. PMID 21130157 DOI: 10.1016/J.Freeradbiomed.2010.11.025 |
0.348 |
|
| 2011 |
Westin ER, Aykin-Burns N, Buckingham EM, Spitz DR, Goldman FD, Klingelhutz AJ. The p53/p21(WAF/CIP) pathway mediates oxidative stress and senescence in dyskeratosis congenita cells with telomerase insufficiency. Antioxidants & Redox Signaling. 14: 985-97. PMID 21087144 DOI: 10.1089/Ars.2010.3444 |
0.361 |
|
| 2011 |
Zagorodna O, Martin S, Kuwana T, Spitz D, Knudson CM. Abstract 9: 2-deoxyglucose caused toxicity is regulated by the Bcl-2 family and is enhanced by Bcl-2 antagonist in lymphoma cell lines Cancer Research. 71: 9-9. DOI: 10.1158/1538-7445.Am2011-9 |
0.405 |
|
| 2011 |
Sobhakumari A, Raeburn A, Fletcher Ev, Spitz DR, Simons AL. EGFR inhibitor Erlotinib induces autophagy via NOX4 in head and neck cancer cells Free Radical Biology and Medicine. 51: S129. DOI: 10.1016/J.Freeradbiomed.2011.10.340 |
0.344 |
|
| 2011 |
Mao G, Jacobus J, Martin S, Case A, Aykin-Burns N, Mapuskar K, Coleman MC, Knudson MC, Gius D, Domann F, Spitz DR. Sirtuin 3−/−Thymocytes Demonstrate Increased Levels of Superoxide, a Diminished Radiation-Induced Adaptive Response, and Accelerated Bax-Induced Thymic Lymphoma in the C57BL/6 mice Free Radical Biology and Medicine. 51: S125-S126. DOI: 10.1016/J.Freeradbiomed.2011.10.328 |
0.786 |
|
| 2011 |
Coleman MC, Olivier AK, Gius D, Spitz DR. The Role of Sirtuin 3 in Hepatic Injury and Loss of Cytochrome Oxidase Following Ionizing Radiation Free Radical Biology and Medicine. 51: S121. DOI: 10.1016/J.Freeradbiomed.2011.10.313 |
0.574 |
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| 2011 |
Fletcher EV, Sobhakumari A, Brown CO, Case AJ, Spitz DR, Domann FE, Goel A, Simons AL. EGFR Inhibition Induces IL6 Expression Via NOX4 in Head and Neck Cancer Cells Free Radical Biology and Medicine. 51: S133-S134. DOI: 10.1016/J.Freeradbiomed.2011.10.278 |
0.321 |
|
| 2010 |
Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H, Kim HS, Flynn CR, Hill S, Hayes McDonald W, Olivier AK, Spitz DR, Gius D. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Molecular Cell. 40: 893-904. PMID 21172655 DOI: 10.1016/J.Molcel.2010.12.013 |
0.618 |
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| 2010 |
Bera S, Greiner S, Choudhury A, Dispenzieri A, Spitz DR, Russell SJ, Goel A. Dexamethasone-induced oxidative stress enhances myeloma cell radiosensitization while sparing normal bone marrow hematopoiesis. Neoplasia (New York, N.Y.). 12: 980-92. PMID 21170263 DOI: 10.1593/Neo.101146 |
0.429 |
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| 2010 |
Fitzgerald MP, Madsen JM, Coleman MC, Teoh ML, Westphal SG, Spitz DR, Radi R, Domann FE. Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity. Radiation Research. 174: 290-6. PMID 20726720 DOI: 10.1667/Rr2235.1 |
0.606 |
|
| 2010 |
Tan M, Zhu Y, Kovacev J, Zhao Y, Pan ZQ, Spitz DR, Sun Y. Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells. Free Radical Biology & Medicine. 49: 976-83. PMID 20638939 DOI: 10.1016/J.Freeradbiomed.2010.05.030 |
0.6 |
|
| 2010 |
Sun WG, Weydert CJ, Zhang Y, Yu L, Liu J, Spitz DR, Cullen JJ, Oberley LW. Superoxide Enhances the Antitumor Combination of AdMnSOD Plus BCNU in Breast Cancer. Cancers. 2: 68-87. PMID 20532186 DOI: 10.3390/Cancers2010068 |
0.819 |
|
| 2010 |
Shutt DC, O'Dorisio MS, Aykin-Burns N, Spitz DR. 2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells. Cancer Biology & Therapy. 9: 853-61. PMID 20364116 DOI: 10.4161/Cbt.9.11.11632 |
0.436 |
|
| 2010 |
Chaudhuri L, Sarsour EH, Kalen AL, Aykin-Burns N, Spitz DR, Goswami PC. Polychlorinated biphenyl induced ROS signaling delays the entry of quiescent human breast epithelial cells into the proliferative cycle. Free Radical Biology & Medicine. 49: 40-9. PMID 20307652 DOI: 10.1016/J.Freeradbiomed.2010.03.012 |
0.383 |
|
| 2010 |
Solazzo SA, Ahmed M, Schor-Bardach R, Yang W, Girnun GD, Rahmanuddin S, Levchenko T, Signoretti S, Spitz DR, Torchilin V, Goldberg SN. Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways. Radiology. 255: 62-74. PMID 20160000 DOI: 10.1148/Radiol.09091196 |
0.394 |
|
| 2010 |
Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, van der Meer R, Nguyen P, Savage J, Owens KM, Vassilopoulos A, Ozden O, Park SH, Singh KK, Abdulkadir SA, ... Spitz DR, et al. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell. 17: 41-52. PMID 20129246 DOI: 10.1016/J.Ccr.2009.11.023 |
0.742 |
|
| 2010 |
Hadzic T, Aykin-Burns N, Zhu Y, Coleman MC, Leick K, Jacobson GM, Spitz DR. Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress. Free Radical Biology & Medicine. 48: 1024-33. PMID 20083194 DOI: 10.1016/J.Freeradbiomed.2010.01.018 |
0.828 |
|
| 2010 |
Spitz DR, Sullivan SJ. The generation of stable oxidative stress-resistant phenotypes in Chinese hamster fibroblasts chronically exposed to hydrogen peroxide or hyperoxia. Methods in Molecular Biology (Clifton, N.J.). 610: 183-99. PMID 20013179 DOI: 10.1007/978-1-60327-029-8_11 |
0.384 |
|
| 2010 |
Lai I, Chai Y, Simmons D, Luthe G, Coleman MC, Spitz D, Haschek WM, Ludewig G, Robertson LW. Acute toxicity of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in male Sprague-Dawley rats: effects on hepatic oxidative stress, glutathione and metals status. Environment International. 36: 918-23. PMID 19969354 DOI: 10.1016/J.Envint.2009.11.002 |
0.607 |
|
| 2010 |
Simons AL, Orcutt KP, Parsons AD, Sibenaller ZA, Scarbrough PM, Sobhakumari A, Zhu Y, Wilke WW, Kalen AL, Miller FJ, Goswami P, Spitz DR. Inhibition of EGFR Signaling Induces Metabolic Oxidative Stress in Human Head and Neck Cancer Cells Free Radical Biology and Medicine. 49: S102-S103. DOI: 10.1016/J.Freeradbiomed.2010.10.270 |
0.804 |
|
| 2010 |
Zhu Y, Tasche KK, Aykin-Burns N, Murphy MP, Spitz DR. Decyl-Triphenylphosphonium Combined with Inhibitors of Hydroperoxide Metabolism Selectively Enhances Breast Cancer Cell Killing via Oxidative Stress Free Radical Biology and Medicine. 49: S74. DOI: 10.1016/J.Freeradbiomed.2010.10.186 |
0.605 |
|
| 2010 |
Sobhakumari A, Parsons A, McCormick M, Spitz DR, Simons A. Head and Neck Cancer Cells Exhibit an Adaptive Response to the AKT-inhibitor Perifosine Characterized by Increased Glucose Metabolism and Altered Signaling Through the AKT Pathway Free Radical Biology and Medicine. 49: S71. DOI: 10.1016/J.Freeradbiomed.2010.10.176 |
0.349 |
|
| 2010 |
Mao G, Jacobus JA, Martin SM, Case AJ, Aykin-Burns N, Mapuskar K, Coleman MC, Gius D, Domann FE, Spitz DR. Low Dose (10-100cGy) Whole Body Irradiation Increases Steady-state Levels of Superoxide in C57BL/6 Thymocytes Free Radical Biology and Medicine. 49: S66. DOI: 10.1016/J.Freeradbiomed.2010.10.158 |
0.768 |
|
| 2010 |
Jacobus JA, Duda C, Martin SM, Coleman MC, Mapuskar K, Aykin-Burns N, Knudson CM, Spitz DR. LET and Gender are Critical Factors in Accelerating Development of Lymphoma in Irradiated Bax Transgenic C57/B6 mice Free Radical Biology and Medicine. 49: S62. DOI: 10.1016/J.Freeradbiomed.2010.10.147 |
0.712 |
|
| 2009 |
Simons AL, Mattson DM, Dornfeld K, Spitz DR. Glucose deprivation-induced metabolic oxidative stress and cancer therapy. Journal of Cancer Research and Therapeutics. 5: S2-6. PMID 20009288 DOI: 10.4103/0973-1482.55133 |
0.466 |
|
| 2009 |
Dayal D, Martin SM, Owens KM, Aykin-Burns N, Zhu Y, Boominathan A, Pain D, Limoli CL, Goswami PC, Domann FE, Spitz DR. Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation. Radiation Research. 172: 737-45. PMID 19929420 DOI: 10.1667/Rr1617.1 |
0.805 |
|
| 2009 |
Zhu Y, Kalen AL, Li L, Lehmler HJ, Robertson LW, Goswami PC, Spitz DR, Aykin-Burns N. Polychlorinated-biphenyl-induced oxidative stress and cytotoxicity can be mitigated by antioxidants after exposure. Free Radical Biology & Medicine. 47: 1762-71. PMID 19796678 DOI: 10.1016/J.Freeradbiomed.2009.09.024 |
0.611 |
|
| 2009 |
Simons AL, Parsons AD, Foster KA, Orcutt KP, Fath MA, Spitz DR. Inhibition of glutathione and thioredoxin metabolism enhances sensitivity to perifosine in head and neck cancer cells. Journal of Oncology. 2009: 519563. PMID 19746172 DOI: 10.1155/2009/519563 |
0.464 |
|
| 2009 |
Du C, Gao Z, Venkatesha VA, Kalen AL, Chaudhuri L, Spitz DR, Cullen JJ, Oberley LW, Goswami PC. Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts. Cancer Biology & Therapy. 8: 1962-71. PMID 19738419 DOI: 10.4161/Cbt.8.20.9648 |
0.603 |
|
| 2009 |
Holley AK, Kiningham KK, Spitz DR, Edwards DP, Jenkins JT, Moore MR. Progestin stimulation of manganese superoxide dismutase and invasive properties in T47D human breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 117: 23-30. PMID 19563893 DOI: 10.1016/J.Jsbmb.2009.06.004 |
0.369 |
|
| 2009 |
Xie W, Wu Q, Kania-Korwel I, Tharappel JC, Telu S, Coleman MC, Glauert HP, Kannan K, Mariappan SV, Spitz DR, Weydert J, Lehmler HJ. Subacute exposure to N-ethyl perfluorooctanesulfonamidoethanol results in the formation of perfluorooctanesulfonate and alters superoxide dismutase activity in female rats. Archives of Toxicology. 83: 909-24. PMID 19544052 DOI: 10.1007/S00204-009-0450-Y |
0.586 |
|
| 2009 |
Fath MA, Diers AR, Aykin-Burns N, Simons AL, Hua L, Spitz DR. Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells. Cancer Biology & Therapy. 8: 1228-36. PMID 19411865 DOI: 10.4161/Cbt.8.13.8631 |
0.479 |
|
| 2009 |
Grdina DJ, Murley JS, Kataoka Y, Baker KL, Kunnavakkam R, Coleman MC, Spitz DR. Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response. International Journal of Radiation Oncology, Biology, Physics. 73: 886-96. PMID 19215822 DOI: 10.1016/J.Ijrobp.2008.10.061 |
0.591 |
|
| 2009 |
Haak JL, Buettner GR, Spitz DR, Kregel KC. Aging augments mitochondrial susceptibility to heat stress. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 296: R812-20. PMID 19144753 DOI: 10.1152/Ajpregu.90708.2008 |
0.326 |
|
| 2009 |
von Bergen NH, Koppenhafer SL, Spitz DR, Volk KA, Patel SS, Roghair RD, Lamb FS, Segar JL, Scholz TD. Fetal programming alters reactive oxygen species production in sheep cardiac mitochondria. Clinical Science (London, England : 1979). 116: 659-68. PMID 19032144 DOI: 10.1042/Cs20080474 |
0.326 |
|
| 2009 |
Mattson DM, Ahmad IM, Dayal D, Parsons AD, Aykin-Burns N, Li L, Orcutt KP, Spitz DR, Dornfeld KJ, Simons AL. Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism. Free Radical Biology & Medicine. 46: 232-7. PMID 18983911 DOI: 10.1016/J.Freeradbiomed.2008.10.023 |
0.793 |
|
| 2009 |
Aykin-Burns N, Ahmad IM, Zhu Y, Oberley LW, Spitz DR. Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. The Biochemical Journal. 418: 29-37. PMID 18937644 DOI: 10.1042/Bj20081258 |
0.818 |
|
| 2009 |
Orcutt K, Wilke W, Scarbrough P, Kalen A, Spitz D, Simons A. The Role of Oxidative Stress in the Cytotoxic Effects of Erlotinib in Human Head and Neck Cancer Cells International Journal of Radiation Oncology*Biology*Physics. 75: S565. DOI: 10.1016/J.Ijrobp.2009.07.1292 |
0.8 |
|
| 2008 |
Gupta AK, Wilke WW, Buatti JM, Spitz DR. The HIV protease inhibitor nelfinavir is synergistic with energy restriction in SQ20b cells resulting in down-regulation of phosphorylated Akt and radiation sensitization. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 22212. PMID 27950261 DOI: 10.1200/Jco.2008.26.15_Suppl.22212 |
0.39 |
|
| 2008 |
Dziegielewski J, Baulch JE, Goetz W, Coleman MC, Spitz DR, Murley JS, Grdina DJ, Morgan WF. WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability. Free Radical Biology & Medicine. 45: 1674-81. PMID 18845240 DOI: 10.1016/J.Freeradbiomed.2008.09.004 |
0.617 |
|
| 2008 |
Jacobs KM, Pennington JD, Bisht KS, Aykin-Burns N, Kim HS, Mishra M, Sun L, Nguyen P, Ahn BH, Leclerc J, Deng CX, Spitz DR, Gius D. SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. International Journal of Biological Sciences. 4: 291-9. PMID 18781224 DOI: 10.7150/Ijbs.4.291 |
0.343 |
|
| 2008 |
Smith-Pearson PS, Kooshki M, Spitz DR, Poole LB, Zhao W, Robbins ME. Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2). Free Radical Biology & Medicine. 45: 1178-89. PMID 18718523 DOI: 10.1016/J.Freeradbiomed.2008.07.015 |
0.41 |
|
| 2008 |
Monick MM, Powers LS, Barrett CW, Hinde S, Ashare A, Groskreutz DJ, Nyunoya T, Coleman M, Spitz DR, Hunninghake GW. Constitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrity. Journal of Immunology (Baltimore, Md. : 1950). 180: 7485-96. PMID 18490749 DOI: 10.4049/Jimmunol.180.11.7485 |
0.62 |
|
| 2008 |
Erickson JR, Joiner ML, Guan X, Kutschke W, Yang J, Oddis CV, Bartlett RK, Lowe JS, O'Donnell SE, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham AJ, Weiss RM, Spitz DR, et al. A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell. 133: 462-74. PMID 18455987 DOI: 10.1016/J.Cell.2008.02.048 |
0.338 |
|
| 2008 |
Dayal D, Martin SM, Limoli CL, Spitz DR. Hydrogen peroxide mediates the radiation-induced mutator phenotype in mammalian cells. The Biochemical Journal. 413: 185-91. PMID 18352860 DOI: 10.1042/Bj20071643 |
0.636 |
|
| 2008 |
van de Wetering CI, Coleman MC, Spitz DR, Smith BJ, Knudson CM. Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma. Free Radical Biology & Medicine. 44: 1677-86. PMID 18291119 DOI: 10.1016/J.Freeradbiomed.2008.01.022 |
0.632 |
|
| 2008 |
Kiningham KK, Cardozo ZA, Cook C, Cole MP, Stewart JC, Tassone M, Coleman MC, Spitz DR. All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF-kappaB. Free Radical Biology & Medicine. 44: 1610-6. PMID 18280257 DOI: 10.1016/J.Freeradbiomed.2008.01.015 |
0.616 |
|
| 2008 |
Coleman MC, Asbury CR, Daniels D, Du J, Aykin-Burns N, Smith BJ, Li L, Spitz DR, Cullen JJ. 2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer. Free Radical Biology & Medicine. 44: 322-31. PMID 18215740 DOI: 10.1016/J.Freeradbiomed.2007.08.032 |
0.667 |
|
| 2008 |
Dornfeld K, Hopkins S, Simmons J, Spitz DR, Menda Y, Graham M, Smith R, Funk G, Karnell L, Karnell M, Dornfeld M, Yao M, Buatti J. Posttreatment FDG-PET uptake in the supraglottic and glottic larynx correlates with decreased quality of life after chemoradiotherapy. International Journal of Radiation Oncology, Biology, Physics. 71: 386-92. PMID 18164842 DOI: 10.1016/J.Ijrobp.2007.09.052 |
0.302 |
|
| 2008 |
Weydert CJ, Zhang Y, Sun W, Waugh TA, Teoh ML, Andringa KK, Aykin-Burns N, Spitz DR, Smith BJ, Oberley LW. Increased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell growth. Free Radical Biology & Medicine. 44: 856-67. PMID 18155673 DOI: 10.1016/J.Freeradbiomed.2007.11.009 |
0.811 |
|
| 2008 |
Ahmad IM, Abdalla MY, Aykin-Burns N, Simons AL, Oberley LW, Domann FE, Spitz DR. 2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress. Free Radical Biology & Medicine. 44: 826-34. PMID 18155176 DOI: 10.1016/J.Freeradbiomed.2007.11.007 |
0.791 |
|
| 2008 |
Venkatachalam P, De Toledo SM, Pandey BN, Tephly LA, Carter AB, Little JB, Spitz DR, Azzam EI. Regulation of normal cell cycle progression by flavin-containing oxidases Oncogene. 27: 20-31. PMID 17637756 DOI: 10.1038/Sj.Onc.1210634 |
0.399 |
|
| 2008 |
Gupta A, Lee J, Wilke W, Buatti J, Spitz D. Comparison of Radiation Response in HPV Induced Squamous Cell Cancer International Journal of Radiation Oncology*Biology*Physics. 72: S687-S688. DOI: 10.1016/J.Ijrobp.2008.06.577 |
0.321 |
|
| 2007 |
Simons AL, Ahmad IM, Mattson DM, Dornfeld KJ, Spitz DR. 2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. Cancer Research. 67: 3364-70. PMID 17409446 DOI: 10.1158/0008-5472.Can-06-3717 |
0.746 |
|
| 2007 |
Fan M, Ahmed KM, Coleman MC, Spitz DR, Li JJ. Nuclear factor-kappaB and manganese superoxide dismutase mediate adaptive radioresistance in low-dose irradiated mouse skin epithelial cells. Cancer Research. 67: 3220-8. PMID 17409430 DOI: 10.1158/0008-5472.Can-06-2728 |
0.617 |
|
| 2007 |
Smith PS, Zhao W, Spitz DR, Robbins ME. Inhibiting catalase activity sensitizes 36B10 rat glioma cells to oxidative stress. Free Radical Biology & Medicine. 42: 787-97. PMID 17320761 DOI: 10.1016/J.Freeradbiomed.2006.11.032 |
0.446 |
|
| 2007 |
Brown KE, Meleah Mathahs M, Broadhurst KA, Coleman MC, Ridnour LA, Schmidt WN, Spitz DR. Increased hepatic telomerase activity in a rat model of iron overload: a role for altered thiol redox state? Free Radical Biology & Medicine. 42: 228-35. PMID 17189828 DOI: 10.1016/J.Freeradbiomed.2006.10.039 |
0.585 |
|
| 2006 |
de Toledo SM, Asaad N, Venkatachalam P, Li L, Howell RW, Spitz DR, Azzam EI. Adaptive responses to low-dose/low-dose-rate gamma rays in normal human fibroblasts: the role of growth architecture and oxidative metabolism. Radiation Research. 166: 849-57. PMID 17149977 DOI: 10.1667/Rr0640.1 |
0.377 |
|
| 2006 |
Yu L, Venkataraman S, Coleman MC, Spitz DR, Wertz PW, Domann FE. Glutathione peroxidase-1 inhibits UVA-induced AP-2alpha expression in human keratinocytes. Biochemical and Biophysical Research Communications. 351: 1066-71. PMID 17097614 DOI: 10.1016/J.Bbrc.2006.10.171 |
0.582 |
|
| 2006 |
Du J, Daniels DH, Asbury C, Venkataraman S, Liu J, Spitz DR, Oberley LW, Cullen JJ. Mitochondrial production of reactive oxygen species mediate dicumarol-induced cytotoxicity in cancer cells. The Journal of Biological Chemistry. 281: 37416-26. PMID 17040906 DOI: 10.1074/Jbc.M605063200 |
0.769 |
|
| 2006 |
Bentle MS, Reinicke KE, Bey EA, Spitz DR, Boothman DA. Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair. The Journal of Biological Chemistry. 281: 33684-96. PMID 16920718 DOI: 10.1074/Jbc.M603678200 |
0.349 |
|
| 2006 |
Luo J, Li L, Zhang Y, Spitz DR, Buettner GR, Oberley LW, Domann FE. Inactivation of primary antioxidant enzymes in mouse keratinocytes by photodynamically generated singlet oxygen. Antioxidants & Redox Signaling. 8: 1307-14. PMID 16910778 DOI: 10.1089/Ars.2006.8.1307 |
0.569 |
|
| 2006 |
Gius D, Spitz DR. Redox signaling in cancer biology. Antioxidants & Redox Signaling. 8: 1249-52. PMID 16910772 DOI: 10.1089/Ars.2006.8.1249 |
0.404 |
|
| 2006 |
Slane BG, Aykin-Burns N, Smith BJ, Kalen AL, Goswami PC, Domann FE, Spitz DR. Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability. Cancer Research. 66: 7615-20. PMID 16885361 DOI: 10.1158/0008-5472.Can-06-0833 |
0.411 |
|
| 2006 |
Weydert CJ, Waugh TA, Ritchie JM, Iyer KS, Smith JL, Li L, Spitz DR, Oberley LW. Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth. Free Radical Biology & Medicine. 41: 226-37. PMID 16814103 DOI: 10.1016/J.Freeradbiomed.2006.03.015 |
0.793 |
|
| 2006 |
Coyle CH, Martinez LJ, Coleman MC, Spitz DR, Weintraub NL, Kader KN. Mechanisms of H2O2-induced oxidative stress in endothelial cells. Free Radical Biology & Medicine. 40: 2206-13. PMID 16785034 DOI: 10.1016/J.Freeradbiomed.2006.02.017 |
0.608 |
|
| 2006 |
Andringa KK, Coleman MC, Aykin-Burns N, Hitchler MJ, Walsh SA, Domann FE, Spitz DR. Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose. Cancer Research. 66: 1605-10. PMID 16452219 DOI: 10.1158/0008-5472.Can-05-3462 |
0.816 |
|
| 2006 |
Laszlo A, Davidson T, Harvey A, Sim JE, Malyapa RS, Spitz DR, Roti Roti JL. Alterations in heat-induced radiosensitization accompanied by nuclear structure alterations in Chinese hamster cells. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 22: 43-60. PMID 16423752 DOI: 10.1080/02656730500394296 |
0.329 |
|
| 2006 |
Nguyen P, Awwad RT, Smart DD, Spitz DR, Gius D. Thioredoxin reductase as a novel molecular target for cancer therapy. Cancer Letters. 236: 164-74. PMID 15955621 DOI: 10.1016/J.Canlet.2005.04.028 |
0.364 |
|
| 2005 |
Hadzic T, Li L, Cheng N, Walsh SA, Spitz DR, Knudson CM. The role of low molecular weight thiols in T lymphocyte proliferation and IL-2 secretion. Journal of Immunology (Baltimore, Md. : 1950). 175: 7965-72. PMID 16339532 DOI: 10.4049/Jimmunol.175.12.7965 |
0.737 |
|
| 2005 |
Wang M, Kirk JS, Venkataraman S, Domann FE, Zhang HJ, Schafer FQ, Flanagan SW, Weydert CJ, Spitz DR, Buettner GR, Oberley LW. Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor. Oncogene. 24: 8154-66. PMID 16170370 DOI: 10.1038/Sj.Onc.1208986 |
0.762 |
|
| 2005 |
Harrison JF, Hollensworth SB, Spitz DR, Copeland WC, Wilson GL, LeDoux SP. Oxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance. Nucleic Acids Research. 33: 4660-71. PMID 16107556 DOI: 10.1093/Nar/Gki759 |
0.4 |
|
| 2005 |
Morrison JP, Coleman MC, Aunan ES, Walsh SA, Spitz DR, Kregel KC. Thiol supplementation in aged animals alters antioxidant enzyme activity after heat stress. Journal of Applied Physiology (Bethesda, Md. : 1985). 99: 2271-7. PMID 16099896 DOI: 10.1152/Japplphysiol.00412.2005 |
0.607 |
|
| 2005 |
Reszka KJ, Wagner BA, Teesch LM, Britigan BE, Spitz DR, Burns CP. Inactivation of anthracyclines by cellular peroxidase. Cancer Research. 65: 6346-53. PMID 16024637 DOI: 10.1158/0008-5472.Can-04-2312 |
0.421 |
|
| 2005 |
Abdalla MY, Ahmad IM, Spitz DR, Schmidt WN, Britigan BE. Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses. Journal of Medical Virology. 76: 489-97. PMID 15977232 DOI: 10.1002/Jmv.20388 |
0.653 |
|
| 2005 |
Morrison JP, Coleman MC, Aunan ES, Walsh SA, Spitz DR, Kregel KC. Aging reduces responsiveness to BSO- and heat stress-induced perturbations of glutathione and antioxidant enzymes. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 289: R1035-41. PMID 15947071 DOI: 10.1152/Ajpregu.00254.2005 |
0.608 |
|
| 2005 |
Menon SG, Coleman MC, Walsh SA, Spitz DR, Goswami PC. Differential susceptibility of nonmalignant human breast epithelial cells and breast cancer cells to thiol antioxidant-induced G(1)-delay. Antioxidants & Redox Signaling. 7: 711-8. PMID 15890017 DOI: 10.1089/Ars.2005.7.711 |
0.654 |
|
| 2005 |
Ridnour LA, Sim JE, Choi J, Dickinson DA, Forman HJ, Ahmad IM, Coleman MC, Hunt CR, Goswami PC, Spitz DR. Nitric oxide-induced resistance to hydrogen peroxide stress is a glutamate cysteine ligase activity-dependent process. Free Radical Biology & Medicine. 38: 1361-71. PMID 15855054 DOI: 10.1016/J.Freeradbiomed.2005.01.023 |
0.783 |
|
| 2005 |
Grishko VI, Rachek LI, Spitz DR, Wilson GL, LeDoux SP. Contribution of mitochondrial DNA repair to cell resistance from oxidative stress. The Journal of Biological Chemistry. 280: 8901-5. PMID 15632148 DOI: 10.1074/Jbc.M413022200 |
0.408 |
|
| 2005 |
Ahmad IM, Aykin-Burns N, Sim JE, Walsh SA, Higashikubo R, Buettner GR, Venkataraman S, Mackey MA, Flanagan SW, Oberley LW, Spitz DR. Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells. The Journal of Biological Chemistry. 280: 4254-63. PMID 15561720 DOI: 10.1074/Jbc.M411662200 |
0.777 |
|
| 2004 |
Hook GJ, Spitz DR, Sim JE, Higashikubo R, Baty JD, Moros EG, Roti Roti JL. Evaluation of parameters of oxidative stress after in vitro exposure to FMCW- and CDMA-modulated radiofrequency radiation fields. Radiation Research. 162: 497-504. PMID 15624304 DOI: 10.1667/Rr3251 |
0.413 |
|
| 2004 |
Lewis A, Ough M, Li L, Hinkhouse MM, Ritchie JM, Spitz DR, Cullen JJ. Treatment of pancreatic cancer cells with dicumarol induces cytotoxicity and oxidative stress. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 4550-8. PMID 15240547 DOI: 10.1158/1078-0432.Ccr-03-0667 |
0.471 |
|
| 2004 |
Spitz DR, Azzam EI, Li JJ, Gius D. Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology. Cancer Metastasis Reviews. 23: 311-22. PMID 15197331 DOI: 10.1023/B:Canc.0000031769.14728.Bc |
0.4 |
|
| 2004 |
Mattson D, Bradbury CM, Bisht KS, Curry HA, Spitz DR, Gius D. Heat shock and the activation of AP-1 and inhibition of NF-kappa B DNA-binding activity: possible role of intracellular redox status. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 20: 224-33. PMID 15195516 DOI: 10.1080/02656730310001619956 |
0.345 |
|
| 2004 |
Gius D, Mattson D, Bradbury CM, Smart DK, Spitz DR. Thermal stress and the disruption of redox-sensitive signalling and transcription factor activation: Possible role in radiosensitization International Journal of Hyperthermia. 20: 213-223. PMID 15195515 DOI: 10.1080/02656730310001619505 |
0.353 |
|
| 2004 |
O'Malley YQ, Reszka KJ, Spitz DR, Denning GM, Britigan BE. Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 287: L94-103. PMID 15020296 DOI: 10.1152/Ajplung.00025.2004 |
0.429 |
|
| 2004 |
Carter AB, Tephly LA, Venkataraman S, Oberley LW, Zhang Y, Buettner GR, Spitz DR, Hunninghake GW. High levels of catalase and glutathione peroxidase activity dampen H2O2 signaling in human alveolar macrophages. American Journal of Respiratory Cell and Molecular Biology. 31: 43-53. PMID 14962975 DOI: 10.1165/Rcmb.2003-0377Oc |
0.546 |
|
| 2004 |
Wen F, Abdalla MY, Aloman C, Xiang J, Ahmad IM, Walewski J, McCormick ML, Brown KE, Branch AD, Spitz DR, Britigan BE, Schmidt WN. Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1. Journal of Medical Virology. 72: 230-40. PMID 14695664 DOI: 10.1002/Jmv.10567 |
0.661 |
|
| 2004 |
Coleman MC, Walsh SA, Li L, Hinkhouse MM, Spitz DR, Cullen J. Inhibition of glucose metabolism in pancreatic cancer induces cytotoxicty via metabolic oxidative stress Journal of the American College of Surgeons. 199: 24. DOI: 10.1016/J.Jamcollsurg.2004.05.037 |
0.669 |
|
| 2003 |
Brown KE, Dennery PA, Ridnour LA, Fimmel CJ, Kladney RD, Brunt EM, Spitz DR. Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats. Liver International : Official Journal of the International Association For the Study of the Liver. 23: 232-42. PMID 12895262 DOI: 10.1034/J.1600-0676.2003.00832.X |
0.339 |
|
| 2003 |
Lee YJ, Song YK, Song JJ, Siervo-Sassi RR, Kim HR, Li L, Spitz DR, Lokshin A, Kim JH. Reconstitution of galectin-3 alters glutathione content and potentiates TRAIL-induced cytotoxicity by dephosphorylation of Akt. Experimental Cell Research. 288: 21-34. PMID 12878156 DOI: 10.1016/S0014-4827(03)00211-8 |
0.402 |
|
| 2003 |
Lin X, Zhang F, Bradbury CM, Kaushal A, Li L, Spitz DR, Aft RL, Gius D. 2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism. Cancer Research. 63: 3413-7. PMID 12810678 |
0.34 |
|
| 2003 |
Narushima S, Spitz DR, Oberley LW, Toyokuni S, Miyata T, Gunnett CA, Buettner GR, Zhang J, Ismail H, Lynch RG, Berg DJ. Evidence for oxidative stress in NSAID-induced colitis in IL10-/- mice. Free Radical Biology & Medicine. 34: 1153-66. PMID 12706496 DOI: 10.1016/S0891-5849(03)00065-0 |
0.536 |
|
| 2003 |
Cullen JJ, Weydert C, Hinkhouse MM, Ritchie J, Domann FE, Spitz D, Oberley LW. The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma. Cancer Research. 63: 1297-303. PMID 12649190 |
0.789 |
|
| 2003 |
Guo G, Yan-Sanders Y, Lyn-Cook BD, Wang T, Tamae D, Ogi J, Khaletskiy A, Li Z, Weydert C, Longmate JA, Huang TT, Spitz DR, Oberley LW, Li JJ. Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses. Molecular and Cellular Biology. 23: 2362-78. PMID 12640121 DOI: 10.1128/Mcb.23.7.2362-2378.2003 |
0.793 |
|
| 2003 |
BROWN K, MATHAS M, SPITZ D. 1290 Activated hepatic stellate cells express a superoxide-generating NAD(P)H oxidase Hepatology. 38: 780-780. DOI: 10.1016/S0270-9139(03)81328-9 |
0.312 |
|
| 2003 |
Wen F, Abdalla MY, Aloman C, Ahmad I, Xiang J, McCormick ML, Brown K, Walewski J, Branch A, Spitz DR, Britigan B, Schmidt WN. HCV core protein promotes increased oxidative stress and glutathione depletion in HepG2 cells that overexpress P450 microsomal enzyme CYP2E1 Gastroenterology. 124: A722. DOI: 10.1016/S0016-5085(03)83646-6 |
0.679 |
|
| 2002 |
Borrelli MJ, Bernock LJ, Landry J, Spitz DR, Weber LA, Hickey E, Freeman ML, Corry PM. Stress protection by a fluorescent Hsp27 chimera that is independent of nuclear translocation or multimeric dissociation. Cell Stress & Chaperones. 7: 281-96. PMID 12482204 DOI: 10.1379/1466-1268(2002)007<0281:Spbafh>2.0.Co;2 |
0.326 |
|
| 2002 |
Kirsch JD, Yi AK, Spitz DR, Krieg AM. Accumulation of glutathione disulfide mediates NF-kappaB activation during immune stimulation with CpG DNA. Antisense & Nucleic Acid Drug Development. 12: 327-40. PMID 12477282 DOI: 10.1089/108729002761381302 |
0.341 |
|
| 2002 |
Zimmerman MC, Lazartigues E, Lang JA, Sinnayah P, Ahmad IM, Spitz DR, Davisson RL. Superoxide mediates the actions of angiotensin II in the central nervous system. Circulation Research. 91: 1038-45. PMID 12456490 DOI: 10.1161/01.Res.0000043501.47934.Fa |
0.626 |
|
| 2002 |
Song JJ, Rhee JG, Suntharalingam M, Walsh SA, Spitz DR, Lee YJ. Role of glutaredoxin in metabolic oxidative stress. Glutaredoxin as a sensor of oxidative stress mediated by H2O2. The Journal of Biological Chemistry. 277: 46566-75. PMID 12244106 DOI: 10.1074/Jbc.M206826200 |
0.372 |
|
| 2002 |
Karimpour S, Lou J, Lin LL, Rene LM, Lagunas L, Ma X, Karra S, Bradbury CM, Markovina S, Goswami PC, Spitz DR, Hirota K, Kalvakolanu DV, Yodoi J, Gius D. Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation. Oncogene. 21: 6317-27. PMID 12214272 DOI: 10.1038/Sj.Onc.1205749 |
0.351 |
|
| 2002 |
Suzuki T, Spitz DR, Gandhi P, Lin HY, Crawford DR. Mammalian resistance to oxidative stress: a comparative analysis. Gene Expression. 10: 179-91. PMID 12173744 DOI: 10.3727/000000002783992442 |
0.39 |
|
| 2002 |
Goswami PC, Higashikubo R, Spitz DR. Redox control of cell cycle-coupled topoisomerase II alpha gene expression. Methods in Enzymology. 353: 448-59. PMID 12078518 DOI: 10.1016/S0076-6879(02)53068-8 |
0.302 |
|
| 2002 |
Sekhar KR, Spitz DR, Harris S, Nguyen TT, Meredith MJ, Holt JT, Gius D, Marnett LJ, Summar ML, Freeman ML, Guis D. Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase. Free Radical Biology & Medicine. 32: 650-62. PMID 11909699 DOI: 10.1016/S0891-5849(02)00755-4 |
0.383 |
|
| 2001 |
Spitz DR, Oberley LW. Measurement of MnSOD and CuZnSOD activity in mammalian tissue homogenates Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. PMID 20954153 DOI: 10.1002/0471140856.Tx0705S08 |
0.528 |
|
| 2001 |
Zhao W, Spitz DR, Oberley LW, Robbins ME. Redox modulation of the pro-fibrogenic mediator plasminogen activator inhibitor-1 following ionizing radiation. Cancer Research. 61: 5537-43. PMID 11454704 |
0.571 |
|
| 2001 |
Li WG, Miller FJ, Zhang HJ, Spitz DR, Oberley LW, Weintraub NL. H2O2-induced O2.- Production by a Non-phagocytic NAD(P)H Oxidase Causes Oxidant Injury Journal of Biological Chemistry. 276: 29251-29256. PMID 11358965 DOI: 10.1074/Jbc.M102124200 |
0.59 |
|
| 2001 |
Mayr NA, Yuh WT, Oberley LW, Spitz D, Sorosky JI, Buatti JM. Serial changes in tumor oxygenation during the early phase of radiation therapy in cervical cancer-are we quantitating hypoxia change? Re: Lying et al., IJROBP 2000; 46:935-946. International Journal of Radiation Oncology, Biology, Physics. 49: 282-9. PMID 11271075 DOI: 10.1016/S0360-3016(00)00794-X |
0.528 |
|
| 2001 |
Lee YJ, Chen JC, Amoscato AA, Bennouna J, Spitz DR, Suntharalingam M, Rhee JG. Protective role in Bcl2 in metabolic oxidative stress-induced cell death Journal of Cell Science. 114: 677-684. PMID 11171373 |
0.31 |
|
| 2001 |
VanderWaal RP, Higashikubo R, Xu M, Spitz DR, Wright WD, Roti Roti JL. Cytometric methods to analyze thermal effects Methods in Cell Biology. 269-286. PMID 11070844 DOI: 10.1016/S0091-679X(01)64018-4 |
0.35 |
|
| 2000 |
Hollensworth SB, Shen C, Sim JE, Spitz DR, Wilson GL, LeDoux SP. Glial cell type-specific responses to menadione-induced oxidative stress. Free Radical Biology & Medicine. 28: 1161-74. PMID 10889445 DOI: 10.1016/S0891-5849(00)00214-8 |
0.415 |
|
| 2000 |
Ercal N, Neal R, Treeratphan P, Lutz PM, Hammond TC, Dennery PA, Spitz DR. A role for oxidative stress in suppressing serum immunoglobulin levels in lead-exposed Fisher 344 rats. Archives of Environmental Contamination and Toxicology. 39: 251-6. PMID 10871428 DOI: 10.1007/S002440010102 |
0.375 |
|
| 2000 |
Ridnour LA, Sim JE, Hayward MA, Wink DA, Martin SM, Buettner GR, Spitz DR. A spectrophotometric method for the direct detection and quantitation of nitric oxide, nitrite, and nitrate in cell culture media. Analytical Biochemistry. 281: 223-9. PMID 10870839 DOI: 10.1006/Abio.2000.4583 |
0.32 |
|
| 2000 |
Spitz DR, Sim JE, Ridnour LA, Galoforo SS, Lee YJ. Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism? Annals of the New York Academy of Sciences. 899: 349-362. PMID 10863552 DOI: 10.1111/J.1749-6632.2000.Tb06199.X |
0.443 |
|
| 2000 |
Lee YJ, Galoforo SS, Sim JE, Ridnour LA, Choi J, Forman HJ, Corry PM, Spitz DR. Dominant-negative Jun N-terminal protein kinase (JNK-1) inhibits metabolic oxidative stress during glucose deprivation in a human breast carcinoma cell line Free Radical Biology and Medicine. 28: 575-584. PMID 10719239 DOI: 10.1016/S0891-5849(99)00267-1 |
0.417 |
|
| 1999 |
Ridnour LA, Winters RA, Ercal N, Spitz DR. Measurement of glutathione, glutathione disulfide, and other thiols in mammalian cell and tissue homogenates using high-performance liquid chromatography separation of N-(1-pyrenyl)maleimide derivatives. Methods in Enzymology. 299: 258-67. PMID 9916204 DOI: 10.1016/S0076-6879(99)99025-0 |
0.371 |
|
| 1999 |
Blackburn RV, Spitz DR, Liu X, Galoforo SS, Sim JE, Ridnour LA, Chen JC, Davis BH, Corry PM, Lee YJ. Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells Free Radical Biology and Medicine. 26: 419-430. PMID 9895234 DOI: 10.1016/S0891-5849(98)00217-2 |
0.413 |
|
| 1998 |
Gurer H, Ozgunes H, Neal R, Spitz DR, Ercal N. Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats Toxicology. 128: 181-189. PMID 9750041 DOI: 10.1016/S0300-483X(98)00074-2 |
0.38 |
|
| 1998 |
Polavarapu R, Spitz DR, Sim JE, Follansbee MH, Oberley LW, Rahemtulla A, Nanji AA. Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil Hepatology. 27: 1317-1323. PMID 9581686 DOI: 10.1002/Hep.510270518 |
0.527 |
|
| 1998 |
Bojes HK, Suresh PK, Mills EM, Spitz DR, Sim JE, Kehrer JP. Bcl-2 and Bcl-x(L) in peroxide-resistant A549 and U87MG cells Toxicological Sciences. 42: 109-116. PMID 9579023 DOI: 10.1006/Toxs.1997.2416 |
0.352 |
|
| 1998 |
Brown KE, Kinter MT, Oberley TD, Freeman ML, Frierson HF, Ridnour LA, Tao Y, Oberley LW, Spitz DR. Enhanced γ-glutamyl transpeptidase expression and selective loss of CuZn superoxide dismutase in hepatic iron overload Free Radical Biology and Medicine. 24: 545-555. PMID 9559866 DOI: 10.1016/S0891-5849(97)00284-0 |
0.529 |
|
| 1998 |
Dennery PA, Spitz DR, Yang G, Tatarov A, Lee CS, Shegog ML, Poss KD. Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. The Journal of Clinical Investigation. 101: 1001-11. PMID 9486970 DOI: 10.1172/Jci448 |
0.371 |
|
| 1998 |
Lee YJ, Galoforo SS, Berns CM, Chen JC, Davis BH, Sim JE, Corry PM, Spitz DR. Glucose deprivation-induced cytotoxicity and alterations in mitogen- activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells Journal of Biological Chemistry. 273: 5294-5299. PMID 9478987 DOI: 10.1074/Jbc.273.9.5294 |
0.432 |
|
| 1997 |
Goswami PC, Albee LD, Spitz DR, Ridnour LA. A polymerase chain reaction assay for simultaneous detection and quantitation of proto-oncogene and GAPD mRNAs in different cell growth rates Cell Proliferation. 30: 271-282. PMID 9451418 DOI: 10.1111/J.1365-2184.1997.Tb00940.X |
0.307 |
|
| 1997 |
Sekhar KR, Meredith MJ, Kerr LD, Soltaninassab SR, Spitz DR, Xu ZQ, Freeman ML. Expression of glutathione and gamma-glutamylcysteine synthetase mRNA is Jun dependent. Biochemical and Biophysical Research Communications. 234: 588-93. PMID 9175757 DOI: 10.1006/Bbrc.1997.6697 |
0.338 |
|
| 1997 |
Dennery PA, Sridhar KJ, Lee CS, Wong HE, Shokoohi V, Rodgers PA, Spitz DR. Heme oxygenase-mediated resistance to oxygen toxicity in hamster fibroblasts. The Journal of Biological Chemistry. 272: 14937-42. PMID 9169465 DOI: 10.1074/Jbc.272.23.14937 |
0.421 |
|
| 1996 |
Dennery PA, Wong HE, Sridhar KJ, Rodgers PA, Sim JE, Spitz DR. Differences in basal and hyperoxia-associated HO expression in oxidant-resistant hamster fibroblasts. The American Journal of Physiology. 271: L672-9. PMID 8897916 DOI: 10.1152/Ajplung.1996.271.4.L672 |
0.413 |
|
| 1996 |
Ercal N, Treeratphan P, Hammond TC, Matthews RH, Grannemann NH, Spitz DR. In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N- acetylcysteine Free Radical Biology and Medicine. 21: 157-161. PMID 8818630 DOI: 10.1016/0891-5849(96)00020-2 |
0.389 |
|
| 1996 |
Guyton KZ, Spitz DR, Holbrook NJ. Expression of stress response genes GADD153, c-jun, and heme oxygenase-1 in H2O2- and O2-resistant fibroblasts Free Radical Biology and Medicine. 20: 735-741. PMID 8721617 DOI: 10.1016/0891-5849(95)02151-5 |
0.386 |
|
| 1995 |
Whit Walker M, Kinter MT, Roberts RJ, Spitz DR. Nitric oxide-induced cytotoxicity: Involvement of cellular resistance to oxidative stress and the role of glutathione in protection Pediatric Research. 37: 41-49. PMID 7700733 DOI: 10.1203/00006450-199501000-00010 |
0.427 |
|
| 1995 |
Spitz DR, Kinter MT, Roberts RJ. Contribution of increased glutathione content to mechanisms of oxidative stress resistance in hydrogen peroxide resistant hamster fibroblasts Journal of Cellular Physiology. 165: 600-609. PMID 7593239 DOI: 10.1002/Jcp.1041650318 |
0.413 |
|
| 1995 |
Dennery PA, McDonagh AF, Spitz DR, Rodgers PA, Stevenson DK. Hyperbilirubinemia results in reduced oxidative injury in neonatal Gunn rats exposed to hyperoxia. Free Radical Biology & Medicine. 19: 395-404. PMID 7590389 DOI: 10.1016/0891-5849(95)00032-S |
0.316 |
|
| 1993 |
Goligorsky MS, Morgan MA, Lyubsky S, Gross RW, Adams DT, Spitz DR. Establishment of a Hydrogen Peroxide Resistant Variant of Renal Tubular Epithelial Cells: Role of Calcium-Independent Phospholipase A2 in Cell Damage Archives of Biochemistry and Biophysics. 301: 119-128. PMID 8442655 DOI: 10.1006/Abbi.1993.1123 |
0.403 |
|
| 1993 |
Warner B, Papes R, Heile M, Spitz D, Wispé J. Expression of human Mn SOD in Chinese hamster ovary cells confers protection from oxidant injury. The American Journal of Physiology. 264: L598-605. PMID 8333551 DOI: 10.1152/Ajplung.1993.264.6.L598 |
0.415 |
|
| 1993 |
Spitz D, Sullivan S, Kinter M, Adams D, Sherman C, Roberts R. Mechanisms of resistance to oxidative stress in O2-resistant cells Free Radical Biology and Medicine. 15: 517. DOI: 10.1016/0891-5849(93)90359-3 |
0.327 |
|
| 1993 |
Walker M, Kinter M, Roberts R, Spitz D. Mechanisms of resistance to oxidative stress protect against nitric oxide induced toxicity Free Radical Biology and Medicine. 15: 500. DOI: 10.1016/0891-5849(93)90297-8 |
0.365 |
|
| 1992 |
Spitz DR, Adams DT, Sherman CM, Roberts RJ. Mechanisms of cellular resistance to hydrogen peroxide, hyperoxia, and 4-hydroxy-2-nonenal toxicity: The significance of increased catalase activity in H2O2-resistant fibroblasts Archives of Biochemistry and Biophysics. 292: 221-227. PMID 1727639 DOI: 10.1016/0003-9861(92)90071-4 |
0.358 |
|
| 1992 |
Park YM, Anderson RL, Spitz DR, Hahn GM. Hypoxia and resistance to hydrogen peroxide confer resistance to tumor necrosis factor in murine L929 cells. Radiation Research. 131: 162-8. PMID 1641471 DOI: 10.2307/3578437 |
0.379 |
|
| 1992 |
Sullivan SJ, Oberley TD, Roberts RJ, Spitz DR. A stable O2-resistant cell line: Role of lipid peroxidation byproducts in O2-mediated injury American Journal of Physiology - Lung Cellular and Molecular Physiology. 262. PMID 1616058 DOI: 10.1152/Ajplung.1992.262.6.L748 |
0.375 |
|
| 1992 |
Spitz DR, Kinter MT, Kehrer JP, Roberts RJ. The effect of monosaturated and polyunsaturated fatty acids on oxygen toxicity in cultured cells Pediatric Research. 32: 366-372. PMID 1408477 DOI: 10.1203/00006450-199209000-00024 |
0.318 |
|
| 1991 |
Sullivan SJ, Roberts RJ, Spitz DR. Replacement of media in cell culture alters oxygen toxicity: Possible role of lipid aldehydes and glutathione transferases in oxygen toxicity Journal of Cellular Physiology. 147: 427-433. PMID 2066363 DOI: 10.1002/Jcp.1041470307 |
0.347 |
|
| 1991 |
Spitz DR, Sullivan SJ, Malcolm RR, Roberts RJ. Glutathione dependent metabolism and detoxification of 4-hydroxy-2-nonenal Free Radical Biology and Medicine. 11: 415-423. PMID 1797627 DOI: 10.1016/0891-5849(91)90159-Z |
0.413 |
|
| 1990 |
Peak MJ, Jones CA, Sedita BA, Dudek EJ, Spitz DR, Peak JG. Evidence that hydrogen peroxide generated by 365-nm UVA radiation is not important in mammalian cell killing. Radiation Research. 123: 220-3. PMID 2389008 DOI: 10.2307/3577548 |
0.345 |
|
| 1990 |
Spitz DR, Elwell JH, Sun Y, Oberley LW, Oberley TD, Sullivan SJ, Roberts RJ. Oxygen toxicity in control and H2O2-resistant Chinese hamster fibroblast cell lines Archives of Biochemistry and Biophysics. 279: 249-260. PMID 2350176 DOI: 10.1016/0003-9861(90)90489-L |
0.592 |
|
| 1990 |
Spitz DR, Malcolm RR, Roberts RJ. Cytotoxicity and metabolism of 4-hydroxy-2-nonenal and 2-nonenal in H2O2-resistant cell lines: do aldehydic by-products of lipid peroxidation contribute to oxidative stress? Biochemical Journal. 267: 453-459. PMID 2334404 DOI: 10.1042/Bj2670453 |
0.405 |
|
| 1990 |
Spitz DR, Li GC. Heat‐induced cytotoxicity in H2O2‐resistant Chinese hamster fibroblasts Journal of Cellular Physiology. 142: 255-260. PMID 2303525 DOI: 10.1002/Jcp.1041420206 |
0.352 |
|
| 1990 |
Freeman ML, Spitz DR, Meredith MJ. Does heat shock enhance oxidative stress? Studies with ferrous and ferric iron. Radiation Research. 124: 288-93. PMID 2175921 DOI: 10.2307/3577841 |
0.316 |
|
| 1990 |
Spitz D, Sullivan S, Malcolm R, Roberts R. Cellular resistance to and metabolism of 4-hydroxy-2-nonenal: A role for glutathione and glutathione transferase Free Radical Biology and Medicine. 9: 128. DOI: 10.1016/B978-0-08-041749-3.50113-3 |
0.302 |
|
| 1990 |
Sullivan S, Roberts R, Adams D, Sherman C, Spitz D. Cytotoxicity and metabolism of 4-hydroxy-2-nonenal in O2-resistant cell lines Free Radical Biology and Medicine. 9: 111. DOI: 10.1016/0891-5849(90)90568-4 |
0.305 |
|
| 1989 |
Spitz DR, Mackey MA, Li GC, Elwell JH, McCormick ML, Oberley LW. Relationship between changes in ploidy and stable cellular resistance to hydrogen peroxide. Journal of Cellular Physiology. 139: 592-8. PMID 2738104 DOI: 10.1002/Jcp.1041390320 |
0.569 |
|
| 1989 |
Spitz DR, Oberley LW. An assay for superoxide dismutase activity in mammalian tissue homogenates Analytical Biochemistry. 179: 8-18. PMID 2547324 DOI: 10.1016/0003-2697(89)90192-9 |
0.515 |
|
| 1988 |
Spitz DR, Li GC, McCormick ML, Sun Y, Oberley LW. The isolation and partial characterization of stable H2O2-resistant variants of Chinese hamster fibroblasts. Basic Life Sciences. 49: 549-52. PMID 3250510 DOI: 10.1007/978-1-4684-5568-7_86 |
0.58 |
|
| 1988 |
Spitz DR, Li GC, McCormick ML, Sun Y, Oberley LW. Stable H 2 O 2 -Resistant Variants of Chinese Hamster Fibroblasts Demonstrate Increases in Catalase Activity Radiation Research. 114: 114. DOI: 10.2307/3577149 |
0.532 |
|
| 1987 |
Spitz DR, Dewey WC, Li GC. Hydrogen peroxide or heat shock induces resistance to hydrogen peroxide in Chinese hamster fibroblasts. Journal of Cellular Physiology. 131: 364-73. PMID 3597544 DOI: 10.1002/Jcp.1041310308 |
0.327 |
|
| 1984 |
Oberley LW, Spitz DR. Assay of superoxide dismutase activity in tumor tissue Methods in Enzymology. 457-464. PMID 6547201 DOI: 10.1016/S0076-6879(84)05064-3 |
0.534 |
|
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